inulin

Summary

Summary: A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.

Top Publications

  1. ncbi Impact of inulin and oligofructose on gastrointestinal peptides
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD FARM PMNT 7369, Universite Catholique de Louvain, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Br J Nutr 93:S157-61. 2005
  2. pmc Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73, PO Box B1 73 11, 1200 Brussels, Belgium
    Gut 62:1112-21. 2013
  3. ncbi Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii
    Carlett Ramirez-Farias
    Microbial Ecology Group, Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Br J Nutr 101:541-50. 2009
  4. ncbi Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice
    Evelyne M Dewulf
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, LDRI, Universite Catholique de Louvain, 1200 Brussels, Belgium
    J Nutr Biochem 22:712-22. 2011
  5. ncbi Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose
    Kaisa Raninen
    Food and Health Research Centre, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Nutr Rev 69:9-21. 2011
  6. ncbi p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin
    Bjorn K I Meijers
    Division of Nephrology, Department of Medicine, University Hospital Leuven, 3000 Leuven, Belgium
    Nephrol Dial Transplant 25:219-24. 2010
  7. ncbi Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Environ Microbiol 13:2667-80. 2011
  8. ncbi Inulin and oligofructose in the dietary fibre concept
    C Cherbut
    Human Nutrition and Gut Function Department, INRA, BP 71627, 44316 Nantes Cedex 03, France
    Br J Nutr 87:S159-62. 2002
  9. ncbi The food additives inulin and stevioside counteract oxidative stress
    Silviya Stoyanova
    Institute of Plant Biology, Biological Research Center, Szeged, Hungary
    Int J Food Sci Nutr 62:207-14. 2011
  10. ncbi The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects
    Joshua Tarini
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada
    Appl Physiol Nutr Metab 35:9-16. 2010

Detail Information

Publications271 found, 100 shown here

  1. ncbi Impact of inulin and oligofructose on gastrointestinal peptides
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD FARM PMNT 7369, Universite Catholique de Louvain, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Br J Nutr 93:S157-61. 2005
    In the present paper, we summarise the data supporting the following hypothesis: dietary inulin-type fructans extracted from chicory root may modulate the production of peptides, such as incretins, by endocrine cells present in the ..
  2. pmc Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73, PO Box B1 73 11, 1200 Brussels, Belgium
    Gut 62:1112-21. 2013
    To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women.
  3. ncbi Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii
    Carlett Ramirez-Farias
    Microbial Ecology Group, Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Br J Nutr 101:541-50. 2009
    ..The bifidogenic effect of the prebiotic inulin is well established; however, it remains unclear which species of Bifidobacterium are stimulated in vivo and ..
  4. ncbi Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice
    Evelyne M Dewulf
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, LDRI, Universite Catholique de Louvain, 1200 Brussels, Belgium
    J Nutr Biochem 22:712-22. 2011
    b>Inulin-type fructans (ITF) are nondigestible/fermentable carbohydrates which are able - through the modification of the gut microbiota - to counteract high-fat (HF) diet-induced obesity, endotoxemia and related-metabolic alterations...
  5. ncbi Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose
    Kaisa Raninen
    Food and Health Research Centre, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Nutr Rev 69:9-21. 2011
    ..Grain fibers are a major natural source of dietary fiber worldwide, while inulin, a soluble indigestible fructose polymer isolated from chicory, and polydextrose, a synthetic indigestible glucose ..
  6. ncbi p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin
    Bjorn K I Meijers
    Division of Nephrology, Department of Medicine, University Hospital Leuven, 3000 Leuven, Belgium
    Nephrol Dial Transplant 25:219-24. 2010
    ..We investigated whether the prebiotic oligofructose-enriched inulin reduced serum concentration of p-cresyl sulfate and indoxyl sulfate, through interference with intestinal ..
  7. ncbi Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats
    Pieter Van den Abbeele
    Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Environ Microbiol 13:2667-80. 2011
    ..how a novel class of potential prebiotic long-chain arabinoxylans (LC-AX) and the well-established prebiotic inulin (IN) modulate the gut microbiota of humanized rats...
  8. ncbi Inulin and oligofructose in the dietary fibre concept
    C Cherbut
    Human Nutrition and Gut Function Department, INRA, BP 71627, 44316 Nantes Cedex 03, France
    Br J Nutr 87:S159-62. 2002
    ..b>Inulin and oligofructose are storage carbohydrates found in a number of vegetables, fruits and whole grains...
  9. ncbi The food additives inulin and stevioside counteract oxidative stress
    Silviya Stoyanova
    Institute of Plant Biology, Biological Research Center, Szeged, Hungary
    Int J Food Sci Nutr 62:207-14. 2011
    Prebiotics such as inulin (Inu)-type fructans and alternative natural sweeteners such as stevioside (Ste) become more popular as food ingredients...
  10. ncbi The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects
    Joshua Tarini
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada
    Appl Physiol Nutr Metab 35:9-16. 2010
    ..Thus, our objective was to determine the effect of the fermentable fibre inulin on postprandial glucose, insulin, SCFA, FFA, and gut hormone responses in healthy subjects...
  11. ncbi Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Br J Nutr 92:521-6. 2004
    ..with 100 g fructans varying in their degrees of polymerization (oligofructose (OFS), Synergy 1 (Syn) or long chain inulin)/kg, male Wistar rats were deprived of food for 8 h before sample collection...
  12. pmc Substrate-driven gene expression in Roseburia inulinivorans: importance of inducible enzymes in the utilization of inulin and starch
    Karen P Scott
    Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Proc Natl Acad Sci U S A 108:4672-9. 2011
    ..inulinivorans A2-194. A cluster of fructo-oligosaccharide/inulin utilization genes induced during growth on inulin included one encoding a β-fructofuranosidase protein that was ..
  13. ncbi Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora
    B Kleessen
    German Institute of Human Nutrition DIfE Potsdam Rehbrucke, Department of Gastrointestinal Microbiology, D 14558 Bergholz Rehbrücke, Germany
    Br J Nutr 86:291-300. 2001
    ..commercial standard diet as a control (Con); (2) Con+50 g short-chain oligofructose/kg (OF); (3) C+50 g long-chain inulin/kg (lcIN); or (4) Con+50 g OF-lcIN/kg (Mix OF-lcIN)...
  14. pmc An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody
    Nikolai Petrovsky
    Vaxine Pty Ltd, Adelaide, Australia
    J Virol 87:10324-33. 2013
    ..the JE-ADVAX vaccine, which contains an inactivated cell culture JE virus antigen formulated with Advax delta inulin adjuvant, could provide heterologous protection against WNV infection in wild-type and β2-microglobulin-deficient ..
  15. ncbi Inulin-type fructans: functional food ingredients
    Marcel B Roberfroid
    Universite Catholique de Louvain, B 1348 Louvain la Neuve, Belgium
    J Nutr 137:2493S-2502S. 2007
    ..The term inulin-type fructans covers all beta(2<--1) linear fructans including native inulin (DP 2-60, DP(av) = 12), ..
  16. ncbi Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects
    D Bosscher
    University of Antwerp, Department of Pharmaceutical Sciences, Antwerp, Belgium
    J Physiol Pharmacol 60:5-11. 2009
    ..provides an up-to-date review of the health benefits associated to the induction of high bifidobacteria levels in the colon by the use of prebiotics (inulin and oligofructose). New areas of emerging science will be discussed as well.
  17. ncbi Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats
    F Bolognani
    TNO-BIBRA International, Carshalton, Surrey, UK
    Eur J Nutr 40:293-300. 2001
    BACKGROUND: Our studies were aimed at investigating the effect of lactic acid producing bacteria (LAB) or inulin, a natural source of non-digestible oligosaccharides derived from chicory, on the induction by carcinogens of aberrant crypt ..
  18. ncbi Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats
    Monika Roller
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany
    J Nutr 134:153-6. 2004
    ..Therefore, PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin enriched with oligofructose), and SYN (combination of PRO and PRE) were fed to F344 rats for 4 wk as supplements ..
  19. ncbi Comparison of plasma clearance of iohexol and urinary clearance of inulin for measurement of GFR in children
    Ulla B Berg
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 57:55-61. 2011
    Very few studies have been published that compare plasma clearance of iohexol (Cio) with renal clearance of inulin (Cin).
  20. ncbi Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects
    N M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT 7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B 1200 Brussels, Belgium
    Br J Nutr 87:S255-9. 2002
    b>Inulin and oligofructose, besides their effect on the gastro-intestinal tract, are also able to exert 'systemic' effect, namely by modifying the hepatic metabolism of lipids in several animal models...
  21. pmc Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel
    S J Langlands
    Department of Gastroenterology, Addenbrookes Hospital, Cambridge, UK
    Gut 53:1610-6. 2004
    ..This study has determined the effect of the prebiotic carbohydrates oligofructose and inulin on the mucosal flora.
  22. ncbi Effects of inulin and enzyme complex, individually or in combination, on growth performance, intestinal microflora, cecal fermentation characteristics, and jejunal histomorphology in broiler chickens fed a wheat- and barley-based diet
    A Rebole
    Departamento de Produccion Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Spain
    Poult Sci 89:276-86. 2010
    A study was undertaken to examine the effects of inulin, alone or in combination with enzyme complex (primarily xylanase and beta-glucanase), on growth performance, ileal and cecal microflora, cecal short-chain fatty acids, and d-lactic ..
  23. ncbi Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials
    Furio Brighenti
    Department of Public Health, University of Parma, Parma, Italy
    J Nutr 137:2552S-2556S. 2007
    Convincing evidence indicates that the intake of inulin-type fructans, inulin and oligofructose, has beneficial effects on blood lipid changes in animals, although data in humans have been considered contradictory...
  24. ncbi Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans
    Beatrice L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
    J Nutr 137:2580S-2584S. 2007
    ..The responsible carcinogens cause mutations or enhance cell growth. Inulin-type fructans may counteract the effects via their gut flora-mediated fermentation products in vitro and in vivo...
  25. ncbi Diets containing inulin but not lupins help to prevent swine dysentery in experimentally challenged pigs
    C F Hansen
    Animal Research Institute, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
    J Anim Sci 88:3327-36. 2010
    ..This experiment was conducted to test the hypothesis that inulin in the chicory root rather than galactans in lupins was responsible for protective effects...
  26. ncbi Production of high fructose syrup from Asparagus inulin using immobilized exoinulinase from Kluyveromyces marxianus YS-1
    Ram Sarup Singh
    Carbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala, Punjab, India
    J Ind Microbiol Biotechnol 34:649-55. 2007
    Extracellular exoinulinase from Kluyveromyces marxianus YS-1, which hydrolyzes inulin into fructose, was immobilized on Duolite A568 after partial purification by ethanol precipitation and gel exclusion chromatography on Sephadex G-100...
  27. ncbi High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake
    Marie Joossens
    Gastroenterology and Leuven Food Science and Nutrition Centre LFoRCe, University Hospital Gasthuisberg, Leuven, Belgium
    FEMS Microbiol Ecol 75:343-9. 2011
    ..Fecal samples from 17 healthy volunteers who consumed 20 g of the prebiotic compound oligofructose-enriched inulin (OF-IN) for 4 weeks were analyzed before and after treatment...
  28. ncbi Dynamics of distribution of 3H-inulin between the cerebrospinal fluid compartments
    Anton Vladic
    Department of Pharmacology and Croatian Institute for Brain Research, University of Zagreb School of Medicine, Salata 11, 10 000 Zagreb, Croatia
    Brain Res 1248:127-35. 2009
    ..of substances between various cerebrospinal fluid (CSF) compartments is poorly understood, we studied (3)H-inulin distribution, over time, after its injection into cisterna magna (CM) or lateral ventricle (LV) or cisterna ..
  29. pmc Estimating glomerular filtration rate: Cockcroft-Gault and Modification of Diet in Renal Disease formulas compared to renal inulin clearance
    Rossini Botev
    Hawaii Permanente Medical Group, 3288 Moanalua Road, Honolulu, Hawaii 96819, USA
    Clin J Am Soc Nephrol 4:899-906. 2009
    ..The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulas are the most commonly used estimations...
  30. ncbi Technological functionality of inulin and oligofructose
    A Franck
    ORAFTI Active Food Ingredients, Research and Development, Aandorenstraat 1, 3300 Tienen, Belgium
    Br J Nutr 87:S287-91. 2002
    b>Inulin and oligofructose are functional food ingredients which offer a unique combination of nutritional properties and important technological benefits...
  31. ncbi Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study
    P Ramnani
    Food Microbial Sciences Unit, Department of Food Microbiology, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 104:233-40. 2010
    The present study aimed to determine the prebiotic effect of fruit and vegetable shots containing inulin derived from Jerusalem artichoke (JA)...
  32. ncbi Determining 'true' glomerular filtration rate in healthy adults using infusion of inulin and comparing it with values obtained using other clearance techniques or prediction equations
    G Sterner
    Department of Nephrology and Transplantation, Malmo University Hospital, Malmo, Sweden
    Scand J Urol Nephrol 42:278-85. 2008
    To determine 'true' glomerular filtration rate (GFR) in healthy adults as renal clearance following infusion of inulin, and compare that result with those obtained using other markers and clearance techniques and with estimations of GFR ..
  33. ncbi A high dietary concentration of inulin is necessary to reduce the incidence of swine dysentery in pigs experimentally challenged with Brachyspira hyodysenteriae
    Christian F Hansen
    Animal Research Institute, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Br J Nutr 106:1506-13. 2011
    ..weighing 31·2 (sd 4·3) kg were used in a randomised block experiment to examine the effect of added dietary inulin (0, 20, 40 and 80 g/kg) on the occurrence of swine dysentery (SD) and on fermentation characteristics in the ..
  34. ncbi Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties
    Jean Michel Lecerf
    Nutrition Department, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Br J Nutr 108:1847-58. 2012
    ..The purpose of the present study was to establish the prebiotic effect of a new xylo-oligosaccharide (XOS) and of an inulin-and-XOS mixture (INU-XOS) and to determine their effect on endotoxaemia (lipopolysaccharides (LPS)) and immune ..
  35. ncbi Fecal microbial communities of healthy adult dogs fed raw meat-based diets with or without inulin or yeast cell wall extracts as assessed by 454 pyrosequencing
    Alison N Beloshapka
    Department of Animal Sciences, University of Illinois, Urbana, IL, USA
    FEMS Microbiol Ecol 84:532-41. 2013
    Our objective was to determine the effects of feeding raw meat-based diets with or without inulin or yeast cell wall extract (YCW) on fecal microbial communities of dogs using 454 pyrosequencing. Six healthy female adult beagles (5...
  36. ncbi Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance
    Masaru Horio
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 15:868-76. 2011
    ..However, detailed studies are limited. We evaluated the performance of cystatin C as a GFR marker...
  37. ncbi The assessment of GFR after orthotopic liver transplantation using cystatin C and creatinine-based equations
    Doris Wagner
    Department of Surgery, Division of Transplant Surgery, Medical University of Graz, Graz, Austria
    Transpl Int 25:527-36. 2012
    ..As reference method, inulin clearance (IC) was estimated...
  38. ncbi Impact of the synbiotic combination of Lactobacillus casei shirota and oligofructose-enriched inulin on the fecal volatile metabolite profile in healthy subjects
    Vicky De Preter
    Translational Research Center for Gastrointestinal Disorders and Leuven Food Science and Nutrition Research Centre, University Hospital Gasthuisberg, KULeuven, Herestraat, Leuven, Belgium
    Mol Nutr Food Res 55:714-22. 2011
    ..However, the emergence of metabolite profiling strategies allows to evaluate the colonic metabolism from a top-down approach. In the present study, we evaluated the impact of a synbiotic combination on fecal metabolite profiles...
  39. ncbi The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis
    Vicky De Preter
    Department of Gastrointestinal Research and Leuven Food Science and Nutrition Centre LFoRCe, University Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Mol Nutr Food Res 54:1791-801. 2010
    ..Only a few studies have focused on the capacity of prebiotics to decrease the proteolytic fermentation, which might contribute to health as well...
  40. ncbi Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum
    Hiroyuki Ito
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    J Agric Food Chem 59:5771-8. 2011
    This study examined the role of degree of polymerization (DP) of inulin-fructans in modulating the interaction between lactic acid bacteria and IgA cecal secretion...
  41. ncbi Introducing inulin-type fructans
    Marcel B Roberfroid
    Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Br J Nutr 93:S13-25. 2005
    b>Inulin is a generic term to cover all beta(2-->1) linear fructans...
  42. ncbi The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women
    K G Jackson
    Department of Food Science and Technology, University of Reading, UK
    Br J Nutr 82:23-30. 1999
    The present study was carried out to examine the effect of the daily intake of 10 g inulin on fasting blood lipid, glucose and insulin levels in healthy middle-aged men and women with moderately raised total plasma cholesterol (TC) and ..
  43. pmc Culture-independent microbial community analysis reveals that inulin in the diet primarily affects previously unknown bacteria in the mouse cecum
    Juha H A Apajalahti
    Danisco Innovation, FIN 02460, Kantvik, Finland
    Appl Environ Microbiol 68:4986-95. 2002
    b>Inulin is a well-known fructose-based prebiotic which has been shown to stimulate the growth of bifidobacteria, a bacterial group generally considered beneficial for intestinal health...
  44. ncbi Gastrointestinal tolerance of chicory inulin products
    Angela L Bonnema
    Department of Food Science and Nutrition, University of Minnesota St Paul, MN 55103, USA
    J Am Diet Assoc 110:865-8. 2010
    The use of inulin in foods as a fiber source has increased recently. Consumption of inulin products can cause gastrointestinal (GI) distress. Acceptable intakes of inulin need to be determined.
  45. pmc In vitro kinetic analysis of fermentation of prebiotic inulin-type fructans by Bifidobacterium species reveals four different phenotypes
    Gwen Falony
    Research Group of Industrial Microbiology and Food Biotechnology, Department of Applied Biological Sciences and Engineering, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Appl Environ Microbiol 75:454-61. 2009
    ..consumption, and metabolite production of 18 Bifidobacterium strains grown on fructose, oligofructose, or inulin were performed...
  46. ncbi Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis
    Carlo F M Welters
    Department of Surgery, University Hospital Maastricht, The Netherlands
    Dis Colon Rectum 45:621-7. 2002
    ..In healthy subjects, inulin, a dietary fiber, is fermented to short chain fatty acids and leads to a lower pH and potentially beneficial ..
  47. ncbi Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem
    Charlotte Grootaert
    Laboratory of Microbial Ecology and Technology LabMET, Universiteit Ghent, Ghent, Belgium
    FEMS Microbiol Ecol 69:231-42. 2009
    In this study, the prebiotic potential of arabinoxylan oligosaccharides (AXOS) was compared with inulin in two simulators of the human intestinal microbial ecosystem...
  48. ncbi Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suppression of hepatic cytochrome P450 and hepatocyte nuclear factor 4alpha expression
    Junko Sugatani
    Department of Pharmaco Biochemistry and COE21, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka City, Shizuoka 422 8526, Japan
    Drug Metab Dispos 34:1677-87. 2006
    b>Inulin enzymatically synthesized from sucrose is a dietary component that completely escapes glucide digestion...
  49. ncbi Effect of honey on the growth of and acid production by human intestinal Bifidobacterium spp.: an in vitro comparison with commercial oligosaccharides and inulin
    S Kajiwara
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824 1224, USA
    J Food Prot 65:214-8. 2002
    ..medium supplemented with 5% (wt/vol) honey, fructooligosaccharide (FOS), galactooligosaccharide (GOS), and inulin. Inoculated samples were incubated anaerobically at 37degrees C for 48 h...
  50. ncbi A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects
    Adele Costabile
    Food Microbial Sciences, School of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 104:1007-17. 2010
    ..In the present study, the impact of a very-long-chain inulin (VLCI), derived from globe artichoke (Cynara scolymus), on the human intestinal microbiota compared with ..
  51. ncbi Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
    Beatrice L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Germany
    Br J Nutr 93:S73-90. 2005
    b>Inulin-type fructans (beta(2,1)fructans) extracted from chicory roots (Cichorium intybus) are prebiotic food ingredients, which in the gut lumen are fermented to lactic acid and SCFA...
  52. ncbi Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice
    Jalil Benyacoub
    Nestle Research Center, CH 1000, Lausanne 26, Switzerland
    J Nutr 138:123-9. 2008
    ..The aim of this study was to investigate the effect of FOS:inulin mix on murine response to Salmonella vaccine and evaluate the relevance toward protection against Salmonella ..
  53. ncbi Effects of dietary soyabean meal, inulin and oxytetracycline on intestinal microbiota and epithelial cell stress, apoptosis and proliferation in the teleost Atlantic salmon (Salmo salar L.)
    Anne Marie Bakke-McKellep
    Aquaculture Protein Centre, CoE, Norway
    Br J Nutr 97:699-713. 2007
    ..Compared to diets containing fishmeal (FM) as the sole protein source, responses to extracted SBM or the prebiotic inulin, with or without oxytetracycline (OTC) inclusion, were studied following a 3-week feeding trial...
  54. ncbi A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans
    S Kolida
    Department of Food Biosciences, Food Microbial Sciences Unit, The University of Reading, Reading, UK
    Eur J Clin Nutr 61:1189-95. 2007
    To evaluate the bifidogenic efficacy of two inulin doses in healthy human adults.
  55. ncbi Cecal parameters of rats fed diets containing grapefruit polyphenols and inulin as single supplements or in a combination
    Zenon Zduńczyk
    Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Division of Food Science, Olsztyn, Poland
    Nutrition 22:898-904. 2006
    We compared the effects of grapefruit flavonoids and inulin, as single dietary components or in a combination, on cecal fermentation in rats adapted to a semipurified diet.
  56. ncbi Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats
    Angelo Pietro Femia
    Department of Pharmacology, University of Florence, 6 Viale Pieraccini, 50139 Florence, Italy
    Carcinogenesis 23:1953-60. 2002
    ..Therefore, we studied whether the prebiotic inulin enriched with oligofructose (Raftilose-Synergy1, briefly, Synergy1, 10% of the diet), probiotics [Bifidobacterium ..
  57. ncbi Inulin, oligofructose and immunomodulation
    Bernhard Watzl
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Haid und Neu Strasse 9, 76131 Karlsruhe, Germany
    Br J Nutr 93:S49-55. 2005
    ..Recent data now provide first evidence that prebiotics such as inulin/oligofructose (IN/OF) modulate functions of the immune system...
  58. ncbi N-glycosylation affects substrate specificity of chicory fructan 1-exohydrolase: evidence for the presence of an inulin binding cleft
    Katrien Le Roy
    K U Leuven, Laboratory of Molecular Plant Physiology, Institute of Botany and Microbiology, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
    New Phytol 176:317-24. 2007
    ..Unfortunately, no such data could be generated with high degree of polymerization (DP) inulin, despite several soaking and cocrystallization attempts...
  59. ncbi Studies with inulin-type fructans on intestinal infections, permeability, and inflammation
    Francisco Guarner
    Digestive System Research Unit, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    J Nutr 137:2568S-2571S. 2007
    Symbiosis between host and gut bacteria can be optimized by prebiotics. Inulin-type fructans have been shown to improve the microbial balance of the intestinal ecosystem by stimulating the growth of bifidobacteria and lactobacilli...
  60. pmc Fermentation of fructooligosaccharides and inulin by bifidobacteria: a comparative study of pure and fecal cultures
    Maddalena Rossi
    Department of Chemistry, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Appl Environ Microbiol 71:6150-8. 2005
    The utilization of fructooligosaccharides (FOS) and inulin by 55 Bifidobacterium strains was investigated. Whereas FOS were fermented by most strains, only eight grew when inulin was used as the carbon source...
  61. pmc Supplemental dietary inulin of variable chain lengths alters intestinal bacterial populations in young pigs
    Jannine K Patterson
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    J Nutr 140:2158-61. 2010
    Previously, we showed that supplementation of diets with short-chain inulin (P95), long-chain inulin (HP), and a 50:50 mixture of both (Synergy 1) improved body iron status and altered expression of the genes involved in iron homeostasis ..
  62. pmc Which creatinine and cystatin C equations can be reliably used in children?
    Justine Bacchetta
    Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques Hôpital Femme Mère Enfant, boulevard Pinel, 69677 Bron Cedex, France
    Clin J Am Soc Nephrol 6:552-60. 2011
    ....
  63. ncbi Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
    Zhonghua Qi
    Department of Medicine, Vanderbilt University, Nashville, TN 37212, USA
    Am J Physiol Renal Physiol 286:F590-6. 2004
    Two nonradioactive methods for determining glomerular filtration rate (GFR) in conscious mice using FITC-labeled inulin (FITC-inulin) were evaluated...
  64. ncbi Dietary inulin affects the expression of intestinal enterocyte iron transporters, receptors and storage protein and alters the microbiota in the pig intestine
    E Tako
    Department of Food Science, Cornell University, Itacha, NY 14853, USA
    Br J Nutr 99:472-80. 2008
    b>Inulin, a linear beta fructan, is present in a variety of plants including chicory root and wheat. It exhibits prebiotic properties and has been shown to enhance mineral absorption and increase beneficial bacteria in the colon...
  65. ncbi Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons
    B Kleessen
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 65:1397-402. 1997
    ..A study was initiated to test the effects of lactose or inulin on the bowel habits of constipated elderly patients and to correlate these effects with several variables measured ..
  66. ncbi Effects of Lactobacillus casei Shirota, Bifidobacterium breve, and oligofructose-enriched inulin on colonic nitrogen-protein metabolism in healthy humans
    Vicky De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 292:G358-68. 2007
    ..In the present study, the influence of oligofructose-enriched inulin (OF-IN), Lactobacillus casei Shirota, and Bifidobacterium breve Yakult on the colonic fate of NH3 and p-cresol was ..
  67. ncbi Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers
    F Brighenti
    Department of Food Science, Technology and Microbiology, University of Milan, Italy
    Eur J Clin Nutr 53:726-33. 1999
    To investigate the effect of a breakfast cereal containing inulin on blood lipids and colonic ecosystem in normolipidemic young men.
  68. ncbi Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice
    J A Harrold
    Kissileff Laboratory for the Study of Human Ingestive Behaviour, Department of Experimental Psychology, Institute of Psychology, Health and Society, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
    Appetite 62:84-90. 2013
    ..commercially available products, a patented herb extract Yerbe Maté, Guarana and Damiana (YGD) formulation and an inulin-based soluble fermentable fibre (SFF), alone or in combination, on appetite and food intake were studied for the ..
  69. ncbi Inulin and probiotics in newly weaned piglets: effects on intestinal morphology, mRNA expression levels of inflammatory marker genes and haematology
    Christiane Mair
    Institute of Animal Nutrition, Products and Nutrition Physiology, VIBT Vienna Institute of BioTechnology, BOKU University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Arch Anim Nutr 64:304-21. 2010
    The study aimed at determining the effect of inulin and/or a multispecies probiotic formulation on gastrointestinal tract (GIT) morphology, immunological and haematological parameters...
  70. ncbi Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors
    Ulla B Berg
    Department of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, S 14186 Stockholm, Sweden
    Nephrol Dial Transplant 21:2577-82. 2006
    ..The golden standard, clearance of inulin, has been used in the present study...
  71. ncbi Supplementation of baby formula with native inulin has a prebiotic effect in formula-fed babies
    Sook He Kim
    Korea Food and Nutrition Foundation, 1523 Punglim VIP Tel, 404 Gongduk Dong, Mapo gu, Seoul 121 718, Korea
    Asia Pac J Clin Nutr 16:172-7. 2007
    In this study we investigated the effects of native inulin on formula-fed babies. The influence of inulin on the microbial composition, pH, consistency and amount of faeces, and on frequency of defecation was assessed.
  72. ncbi Expression of inulinase gene in the oleaginous yeast Yarrowia lipolytica and single cell oil production from inulin-containing materials
    Chun Hai Zhao
    Unesco Chinese Center of Marine Biotechnology and Institute of Marine Biodiversity and Evolution, Ocean University of China, Yushan Road, No 5, Qingdao, China
    Metab Eng 12:510-7. 2010
    ..3% (w/w) oil from inulin in its cells and cell dry weight was 11.6 g L(-1) within 78 h at the flask level...
  73. ncbi The bifidogenic effect of inulin and oligofructose and its consequences for gut health
    D Meyer
    Sensus, Roosendaal, The Netherlands
    Eur J Clin Nutr 63:1277-89. 2009
    The bifidogenic effect of inulin and oligofructose is now well established in various studies, not only in adult participants but also in other age groups...
  74. ncbi [Bifidobacteria and inulin-type fructans which stimulate their growth]
    Marzena Jedrzejczak-Krzepkowska
    Institute of Technical Biochemistry, Technical University of Lodz, Lodz, Poland
    Postepy Biochem 57:392-400. 2011
    ..This paper summarizes the current state of knowledge on bifidobacteria and inulin type fructans they ferment...
  75. ncbi Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic rats
    Petya T Koleva
    Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, AB, Canada
    Br J Nutr 108:1633-43. 2012
    ..The aim of the present study was to assess the effects of inulin and fructo-oligosaccharides (FOS) on intestinal microbiota and colitis in HLA-B27 transgenic rats, a well-..
  76. ncbi Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans
    Fabien Forcheron
    INSERM U 499, Faculté RTH Laennec, IFR 62, Universite Claude Bernard Lyon, 69008 Lyon, France
    Metabolism 56:1093-8. 2007
    Short-term studies have shown that the addition to diet of inulin-type fructans, a nondigestible carbohydrate, may have a plasma lipid-lowering effect in humans...
  77. ncbi Inulin, oligofructose and mineral metabolism - experimental data and mechanism
    Katharina E Scholz-Ahrens
    Institute of Physiology and Biochemistry of Nutrition, Federal Dairy Research Centre, Hermann Weigmann Str 1, 24103 Kiel, Germany
    Br J Nutr 87:S179-86. 2002
    ..in animal models in the past 10 years have shown repeatedly that non-digestible oligosaccharides (NDO), such as inulin, oligofructose or transgalacto-oligosaccharides (TOS), stimulate mineral absorption, mainly calcium and magnesium...
  78. ncbi In vitro batch fecal fermentation comparison of gas and short-chain fatty acid production using "slowly fermentable" dietary fibers
    Amandeep Kaur
    Whistler Center for Carbohydrate Research and Dept of Food Science, Purdue Univ, West Lafayette, IN 47907, USA
    J Food Sci 76:H137-42. 2011
    ..Dietary fibers with previous reports of slow fermentation, namely, long-chain inulin, psyllium, alkali-soluble corn bran arabinoxylan, and long-chain β-glucan, as well as starch-entrapped ..
  79. ncbi Inulin/oligofructose and anticancer therapy
    H S Taper
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Universite Catholique de Louvain, PMNT 73 69, Avenue Em Mounier, 73, B 1200 Bruxelles, Belgium
    Br J Nutr 87:S283-6. 2002
    The results of our investigations indicate that dietary treatment with inulin or oligofructose incorporated in the basal diet for experimental animals: (i) reduced the incidence of mammary tumors induced in Sprague-Dawley rats by ..
  80. ncbi Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat
    S Videla
    Department of Microbiology, Hospital General Vall d'Hebron, Barcelona, Spain
    Am J Gastroenterol 96:1486-93. 2001
    OBJECTIVES: Inulin stimulates intracolonic generation of butyrate and growth of lactic acid bacteria. This study investigated whether inulin protects against colitis...
  81. ncbi Inulin and oligofructose in chronic inflammatory bowel disease
    Celine H M Leenen
    Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada
    J Nutr 137:2572S-2575S. 2007
    ..probiotic bacteria to patients with IBD, there has been interest in the prophylactic and therapeutic potential of inulin, oligofructose, and other prebiotics for patients with or at risk of IBD...
  82. ncbi [Systematic review of the effects of inulin-type fructans on blood lipid profiles: a meta-analysis]
    Ting Wu
    Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Wei Sheng Yan Jiu 39:172-6. 2010
    To conduct a systematic review on the efficacy of inulin-type fructans on lowering blood lipids, randomized controlled intervention trials on the analysis of plasma total cholesterol and triacylglycerol resulted from the treatment of ..
  83. ncbi From inulin to fructose syrups using sol-gel immobilized inulinase
    Gonçalo L M Santa
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001, Lisbon, Portugal
    Appl Biochem Biotechnol 165:1-12. 2011
    ..immobilized inulinase, a biocatalyst configuration yet unexploited, using as model system the hydrolysis of inulin to fructose...
  84. ncbi Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice
    Marie Hélène Rault-Nania
    Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR1019, INRA, Theix, Centre de Recherche en Nutrition Humaine d Auvergne, 63122 Saint Genes Champanelle, France
    Br J Nutr 96:840-4. 2006
    Effects of different inulin-type fructan fractions were studied on atherosclerotic plaque formation in male apo E-deficient mice...
  85. ncbi The state of the art in the production of fructose from inulin enzymatic hydrolysis
    Emanuele Ricca
    Department of Chemical Engineering and Materials, University of Calabria, Arcavacata di Rende, Italy
    Crit Rev Biotechnol 27:129-45. 2007
    ..work reviews the main advancements achieved in the last decades in the study of the fructose production process by inulin enzymatic hydrolysis...
  86. ncbi Development of a stable continuous flow immobilized enzyme reactor for the hydrolysis of inulin
    Ram Sarup Singh
    Carbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala, 147 002 Punjab, India
    J Ind Microbiol Biotechnol 35:777-82. 2008
    ..A568 has been used for the development of a continuous flow immobilized enzyme reactor for the hydrolysis of inulin. In a packed bed reactor containing 72 IU of exoinulinase from Kluyveromyces marxianus YS-1, inulin solution (5%, ..
  87. pmc Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum
    Janina Post
    Westphalian Wilhelms University of Munster, Institute of Plant Biology and Biotechnology, 48143 Münster, Germany
    Plant Physiol 158:1406-17. 2012
    ..biosynthesis and a corresponding 50% increase in the levels of triterpenes and the main storage carbohydrate, inulin. Transmission electron microscopy revealed that the laticifers in CPT-RNAi plants contained fewer and smaller ..
  88. ncbi Physicochemical characterization and biological effects of inulin enzymatically synthesized from sucrose
    Tadashi Wada
    Fuji Nihon Seito Corporation, 1 4 10 Shimizuseikai, Shizuoka City, Shizuoka 424 8737, Japan
    J Agric Food Chem 53:1246-53. 2005
    We first developed the method to produce inulin from sucrose using an enzyme from Bacillus sp. 217C-1. Synthesized inulin consists of a linear polymer having beta(2-1) linkages of d-fructose with one terminal glucose...
  89. ncbi Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis
    Monika Roller
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Haid und Neu Str 9, 76131 Karlsruhe, Germany
    Br J Nutr 92:931-8. 2004
    ..Therefore, the effects of PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin-based enriched with oligofructose, 100 g/kg) and SYN (combination of PRO and PRE) on the immune system of rats ..
  90. ncbi The influence of inulin on the absorption of nitrogen and the production of metabolites of protein fermentation in the colon
    Karen P Geboes
    Laboratory of Digestion and Absorption, Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Br J Nutr 96:1078-86. 2006
    ..carbohydrate fermentation in order to prevent accumulation of these toxic metabolites was induced by inclusion of inulin in a test meal or by addition of inulin to the daily diet, allowing us to distinguish between changes induced by ..
  91. ncbi Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects
    T Van De Wiele
    Laboratory Microbial Ecology and Technology LabMET, Ghent University, Ghent, Belgium
    J Appl Microbiol 102:452-60. 2007
    ..We assessed to what extent fructans of different degrees of polymerization (DP) differ in their prebiotic effectiveness towards in vitro microbial communities from the proximal and distal colon...
  92. ncbi Generation of Maillard compounds from inulin during the thermal processing of Agave tequilana Weber Var. azul
    Norma A Mancilla-Margalli
    Unidad de Biotecnología e Ingeniería Genética de Plantas, Centro de Investigacion y Estudios Avanzados del IPN, Apartado Postal 629, 36500 Irapuato, Gto, Mexico
    J Agric Food Chem 50:806-12. 2002
    During the cooking process of Agave tequilana Weber var. azul to produce tequila, besides the hydrolysis of inulin to generate fermentable sugars, many volatiles, mainly Maillard compounds, are produced, most of which may have a ..
  93. ncbi Functional foods: concepts and application to inulin and oligofructose
    Marcel B Roberfroid
    Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 87:S139-43. 2002
    ..The functional food components that are discussed in the proceedings of the 3rd ORAFTI Research Conference are the inulin-type fructans, natural food components found in miscellaneous edible plants...
  94. ncbi Inulin and oligofructose: effects on lipid metabolism from human studies
    C M Williams
    Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, The University of Reading, UK
    Br J Nutr 87:S261-4. 2002
    Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings...
  95. ncbi Inulin stimulates phagocytosis of PMA-treated THP-1 macrophages by involvement of PI3-kinases and MAP kinases
    Yukitoshi Nagahara
    Department of Biotechnology, College of Science and Engineering, Tokyo Denki University, Hatoyama, Hiki gun, Saitama, Japan
    Biofactors 37:447-54. 2011
    b>Inulin is a polysaccharide that enhances various immune responses, mainly to T and B cells, natural killer cells, and macrophages in vivo and in vitro...
  96. ncbi Pediatric applications of inulin and oligofructose
    Gigi Veereman
    Pediatric Gastroenterology and Nutrition, Queen Paola Children s Hospital ZNA, 2020 Antwerp, Belgium
    J Nutr 137:2585S-2589S. 2007
    b>Inulin-type fructans have been used in infants and children because of their prebiotic potential to modulate the intestinal flora and influence the innate and adaptive immune response favorably...
  97. ncbi Inulin and oligofructose: review of experimental data on immune modulation
    Stephanie Seifert
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, 76131 Karlsruhe, Germany
    J Nutr 137:2563S-2567S. 2007
    ..First results from human intervention studies suggest that the intake of inulin (IN) and oligofructose (OF) has beneficial effects on the gut-associated lymphoid tissue...
  98. ncbi Inulin determination for food labeling
    A Zuleta
    Faculty of Pharmacy and Biochemistry, University of Buenos Aires, , 1113) Buenos Aires, Argentina
    J Agric Food Chem 49:4570-2. 2001
    b>Inulin and oligofructose exhibit valuable nutritional and functional attributes, so they are used as supplements as soluble fiber or as macronutrient substitutes...
  99. pmc Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats
    Nadia Osman
    Dept of Surgery University Hospital Malmö, Lund University, 205 02 Malmo, Sweden
    BMC Gastroenterol 6:31. 2006
    ..Bifidobacterium are saccharolytic and their growth in the gut can be promoted by non-absorbable carbohydrates and its increase in the colon appears to be of benefit...
  100. ncbi Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers
    Brigitta Kleessen
    Institute of Bacteriology and Mycology, Veterinary Faculty, University of Leipzig, An den Tierkliniken 29, D 04103 Leipzig, Germany
    Br J Nutr 98:540-9. 2007
    A study was conducted to test the effects of Jerusalem artichoke inulin (JA) or chicory inulin (CH) in snack bars on composition of faecal microbiota, concentration of faecal SCFA, bowel habit and gastrointestinal symptoms...
  101. pmc Lactobacillus paracasei subsp. paracasei 8700:2 degrades inulin-type fructans exhibiting different degrees of polymerization
    Lefteris Makras
    Research Group of Industrial Microbiology, Fermentation Technology and Downstream Processing IMDO, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Appl Environ Microbiol 71:6531-7. 2005
    Ten strains of lactobacilli were assessed for their capacity to degrade inulin-type fructans, which are well-known prebiotics. Both oligofructose and inulin were tested...

Research Grants62

  1. Activation of Host-Probiotic Communication by Prebiotic Milk Oligosaccharides
    Helen E Raybould; Fiscal Year: 2012
    ..during growth human milk glycans but are not expressed in cells grown on lactose or current commercial prebiotics-inulin or galactooligosaccharides (GOS)...
  2. Acetaldehyde and Epithelial Junctions: Role of PP2A and Occludin Phosphorylation
    MITZI LEE DUNAGAN; Fiscal Year: 2011
    ..will be achieved by examining acetaldehyde-induced disruption of tight junctions with transepithelial resistance, inulin flux, and immunofluorescence confocal microscopy...
  3. Impact of Diet on Intestinal Microbiota-Host Dynamics
    Justin Sonnenburg; Fiscal Year: 2013
    ..model microbiotas composed of bacterial species with differing relative abilities to utilize the dietary fructan, inulin, adapt within the gnotobiotic mouse gut to dietary inulin supplementation;(iii) determine if host epithelial gene ..
  4. Roles of Streptococcus mutans YidC1 and YidC2 in membrane biogenesis
    SARA RASER PALMER; Fiscal Year: 2010
    ..mutans has not been achieved. A conditional expression system using the inulin inducible, glucose repressible fruA promoter will be developed to assess the relative roles of YidC1 and YidC2 in ..
  5. Anti-inflammatory Therapy in Diabetic CKD
    DOMINIC S RAJ; Fiscal Year: 2013
    ..Prebiotic oligofructose enriched inulin (p-inulin) has been shown to restore gut microbial balance, thereby reducing endotoxin generation and attenuating ..
  6. Inulin immunoassay for kidney function
    Ernest V Groman; Fiscal Year: 2013
    ..b>Inulin is the gold standard fo measuring GFR...
  7. Gut Microbiota and Atherosclerosis in ESRD
    DOMINIC S RAJ; Fiscal Year: 2013
    ..Prebiotic oligofructose enriched inulin (p-inulin) has been shown to restore gut microbial balance, thereby reducing endotoxin generation and inflammation...
  8. Inulin immunoassay for kidney function
    Ernest V Groman; Fiscal Year: 2010
    ..b>Inulin is the gold standard for measuring GFR...
  9. Migration of polyomavirus JC across the blood-brain-barrier
    Vivek Nerurkar; Fiscal Year: 2009
    ..the expression of junctional proteins, claudin-1 and -5 and occludin, TEER, and paracellular markers, such as inulin or dextran, before, during and after transmigration of JCV...
  10. NS1 protein of H5N1 disrupts epithelial barrier of the gut and lung
    VERONICA CONOLEY; Fiscal Year: 2009
    ..These studies will use the following techniques: transepithelial resistance measuremets, inulin flux measurements, immunofluorescent staining, cell migration assays, and protein binding studies...
  11. BEHAVIORALLY INDUCED SNS AROUSAL AND SODIUM REGULATION
    Gregory Harshfield; Fiscal Year: 1990
    ..we will measure blood pressure and heart rate, renal plasma flow (PAH), glomerular filtration rate (creatinine or inulin), proximal Na+ reabsorption (lithium clearance), total ENa+, plasma renin activity, aldosterone and cortisol to ..
  12. CHARACTERIZATION OF CYCLOSPORINE NEPHROTOXICITY
    Richard Wait; Fiscal Year: 1991
    ..Renal functional parameters to be studied include renal blood flow (flow probes), autoregulation of blood flow, inulin and lithium clearance, osmolar clearance, sodium and potassium excretion, excretion rates of n-acetyl-B-..
  13. Delivery of Agents by Modulating Junctions with Zot
    Natalie Eddington; Fiscal Year: 2006
    ..SA3. To examine the ability of Zot to enhance the oral bioavailability of the hydrophilic agents (mannitol, inulin) and therapeutic macromolecules (insulin, cyclosporin A, paclitaxel)...
  14. CLINICAL PHARMACOLOGY OF COMMONLY USED DRUGS
    ARTHUR ATKINSON; Fiscal Year: 1990
    ..In Project 1, we propose the first clinical studies using inulin and urea to calculate transcapillary exchange parameters...
  15. Internal environment of the developing brain
    Norman Saunders; Fiscal Year: 2006
    ..and compared with results with classical but non-visualizable permeability probes (radiolabelled sucrose & inulin)...
  16. MECHANISMS OF POSTISCHEMIC ACUTE RENAL FAILURE
    Bryan Myers; Fiscal Year: 1999
    ..GFR (inulin clearance) and its remaining four determinants will be evaluated 1-3 hr and 7 days after reperfusion of the Tx...
  17. PERMEABILITY KINETICS AND NO IN EXPERIMENTAL MENINGITIS
    KATHLEEN BOJE; Fiscal Year: 1999
    ..pharmacokinetic methods or in vitro tissue culture methods, utilizing molecular size markers ({14C}-source, {14C}-inulin and {3H}- dextran) which ordinarily do not cross the B-B and B-CSF barrier permeability will be examined under in ..
  18. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..course after injury, compare the results with those of permeability markers (radioactively labeled albumin and inulin as indicators of barrier disruption), and test the effects of receptor antibodies and endocytosis inhibitors on ..
  19. IN VITRO MODEL OF POLARIZED TROPHOBLAST
    Joseph Dancis; Fiscal Year: 1993
    ..for a successful preparation will include tests of barrier function (electrical resistance, restricted transfer of inulin and other molecules, microscopic evidence of a continuous monolayer) and tests of polarity (differentiation into ..
  20. SITES AND MECHANISMS OF PLASMA PROTEIN CATABOLISM
    Suzanne Thorpe; Fiscal Year: 1992
    ..During the last two years we have prepared and characterized an improved radioactive label, inulin-125I-tyramine, and a new fluorescent label, N,N--dilactitol-N'-fluoresceinyl- ethylenedlamine, and have continued ..
  21. Novel vaccine adjuvants to counter bioterrorist threats
    Nikolai Petrovsky; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This Project's primary goal is to develop the use of gamma inulin-based adjuvants as safe and effective adjuvants for use in vaccines against Category A, B and C bioterrorism pathogens...
  22. CHIMERIC KIDNEY
    MARC HAMMERMAN; Fiscal Year: 2001
    ..Transplanted metanephroi clear inulin from the circulation...
  23. CHIMERIC KIDNEY
    MARC HAMMERMAN; Fiscal Year: 2003
    ..such that they undergo growth and differentiation in hosts, acquire a blood supply from the host, and clear inulin from the host's circulation; 2) metanephroi can be transplanted across the rat MHC and this is possible because of ..
  24. DIABETES: SUGAR FLUXES IN INTERNALLY PERFUSED MUSCLE
    STANLEY SPANGLER; Fiscal Year: 1980
    ..with the external fluid compartment, muscle fibers have been exposed to solutions containing either tritiated inulin (which is thought to be excluded from the SR) or tritiated sucrose (which may or may not be free to enter the SR)...
  25. GF REGULATION/GASTRIC MUCOSAL PARACELLULAR PERMEABILITY
    ANDREW SOLL; Fiscal Year: 2003
    ..on paracellular permeability and barrier function, as measured by transepithelial resistance and by mannitol and inulin flux, will be compared...
  26. Intra-renal Bold MRI: Application to Diabetic Nephropathy
    Pottumarthi Prasad; Fiscal Year: 2009
    ..Using a diabetic rat kidney model, BOLD MRI and GFR measurements will be validated against invasive microprobe and inulin clearance measurements...
  27. Anti-PSCA allosteric CLAMPs
    Richard Hamilton; Fiscal Year: 2004
    ..The allosteric CLAMP will be designed to bind inulin only when it is bound to PSCA...
  28. MDCK CELL MUTANTS DEFECTIVE IN GLYCOPROTEIN MATURATION
    JEFFREY MAYNE; Fiscal Year: 1990
    ..l Infected monolayers of clones 32 and 39 will be tested by 3H-inulin diffusion and electron microscopic studies to determine whether the junctional complexes are intact...
  29. Smart Probes for Imaging Cancer
    Richard Hamilton; Fiscal Year: 2004
    ..cell surface will activate the second aptamer that binds the imaging agent which is attached to a polymer such as inulin. The allosteric CLAMPs are expected to provide the following advantages for imaging: 1) relatively rapid renal ..
  30. Antioxidant Functions of Lipoic Acid
    James May; Fiscal Year: 2004
    ..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..
  31. Antioxidant Interaction of Selenium and Vitamins C & E
    James May; Fiscal Year: 2008
    ..Using this approach, it will be possible to relate the crucial, mitochondrial functions of selenium and vitamins C and E to the antioxidant defenses of the whole animal. ..
  32. Antioxidant vitamins in models of Alzheimer's Disease
    James May; Fiscal Year: 2008
    ..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
  33. Colonic Bacterial Synthesis of Butyric Acid
    CRAIG KIEN; Fiscal Year: 2004
    ..Fructooligosaccharides such as inulin cause a beneficial increase in bifidobacteria in the colon (prebiotic effect), but it is not clear if feeding ..
  34. DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS
    CRAIG KIEN; Fiscal Year: 2003
    ..In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding. ..
  35. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..important new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  36. A Novel and Non-Invasive Method of Dermal Sampling
    Samir Mitragotri; Fiscal Year: 2003
    ..abstract_text> ..
  37. GENISTEIN AS MODULATOR OF ANTIOXIDANT PROTEIN EXPRESSION
    Shiu Ming Kuo; Fiscal Year: 2002
    ..These studies may also lead to the identification of a previous unknown pathway for Gn to regulate mammalian genes. ..
  38. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006
    ..3. Using an in vitro model, Epiderm, and in vivo mouse model, assess safety of skin exposure to low-frequency ultrasound. ..
  39. MECHANISMS OF RISK TO DIABETIC NEPHROPATHY IN BLACKS
    Deborah Price; Fiscal Year: 2003
    ..Our goal in this study is to explore preliminary evidence that RAS activation and the combination with other polymorphic genes accounts for many Type II DM features involving renal risk and racial differences in risk. ..
  40. RENAL TRANSPORT OF NONELECTROLYTES, SALT AND WATER
    James Schafer; Fiscal Year: 2002
    ..These observations will provide important information regarding the physiological or pathophysiological circumstances under which AVP would contribute to salt retention. ..
  41. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  42. Molecular Epidemiology of Colorectal Cancer Subtypes
    Paul J Limburg; Fiscal Year: 2010
    ....
  43. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    THOMAS PALLONE; Fiscal Year: 2003
    ....
  44. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  45. MRI OF RENAL ANATOMY AND FUNCTION IN CHRONIC ISCHEMIA
    Frank Sommer; Fiscal Year: 2002
    ..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..
  46. MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
    Anthony Blikslager; Fiscal Year: 2002
    ..These experiments will provide insight into the signaling pathways and mechanisms by which prostaglandins trigger repair of acutely-injured intestinal epithelium. ..
  47. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    THOMAS PALLONE; Fiscal Year: 2002
    ..Exchange of albumin and middle molecular weight solutes will also be simulated. ..
  48. GM-CSF responsiveness in alcohol-mediated lung injury
    David Guidot; Fiscal Year: 2009
    ..The ultimate goal of this project is to develop human recombinant GM-CSF as a therapy for patients at high risk for acute lung injury as a consequence of chronic alcohol abuse. ..
  49. Insulin, the IGF Axis, and Colorectal Neoplasia
    Paul Limburg; Fiscal Year: 2005
    ..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to academic research. ..
  50. Visualizing COX-2 in kidney function and development
    Victoria Norwood; Fiscal Year: 2005
    ..This proposal will therefore answer vital, basic, currently inaccessible, questions about the biology of COX-2, eicosanoid pathways in the kidney, and the mechanisms by which COX-2 regulates renal development. ..
  51. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..These studies will not only examine the pathogenesis of this disorder, but will directly examine if indomethacin potentially represents a novel therapy for this disease. ..
  52. Placenta: Ethanol and HIV
    Richard Miller; Fiscal Year: 2004
    ..The experiments proposed will provide the first evidence on whether ethanol plays a role in direct transmission of the HIV virus to the fetus. ..
  53. Delayed Neurodegeneration After Intracerebral Hemorrhage
    Guohua Xi; Fiscal Year: 2007
    ..If our hypotheses are correct, these experiments may lead to novel therapies for ICH by either limiting iron overload or attenuating oxidative brain injury. [unreadable] [unreadable]..
  54. Opiate's Effects on the Inflammation and Cytotoxicity in HIV-1 Transgenic Rat
    SULIE CHANG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. HIV-1 and ethanol-induced alveolar epithelial and macrophage dysfunction
    David Guidot; Fiscal Year: 2007
    ..Ultimately, the long-term goal of this project is to identify effective new adjunctive therapies that can complement standard treatment and enhance lung function in HIV-1-infected individuals. [unreadable] [unreadable] [unreadable]..
  56. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007
    ..Attendance of young scientists insures that the information will be translated into future studies that elucidate the role of ROS in kidney diseases and treatment thereof. [unreadable] [unreadable] [unreadable]..
  57. TNF Mediates Obstruction-Induced Renal Injury
    KIRSTAN MELDRUM; Fiscal Year: 2008
    ..and enhance the knowlegde gained by the applicant during her residency and fellowship training to develop a clinically relevant therapeutic approach to the treatment and prevention of obstructive renal injury [unreadable] [unreadable]..
  58. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Guohua Xi; Fiscal Year: 2009
    ..The purpose of our project is to investigate the mechanisms involved in thrombin-induced brain edema. If our hypotheses are correct, these experiments may lead to novel methods of treating ICH. ..
  59. Urine Antiproliferative Peptide in Interstitial Cystitis
    Susan Keay; Fiscal Year: 2009
    ..Data from these studies should yield valuable information regarding the structure and mechanism of activity for APF, and may also lead to the identification of potential therapies for this disorder. ..
  60. Calcium Signaling in Vasa Recta Endothelium
    THOMAS PALLONE; Fiscal Year: 2004
    ..We will test whether DVR contractions to norepinephrine, Angll and KCI are increased, measure NO production and assess effects of OH on endothelial and pericyte Ca2+ signaling. ..
  61. Invasion of C. neoformans into brain endothelial cells
    Ambrose Jong; Fiscal Year: 2008
    ..The information derived from the studies is expected to be helpful in the development of novel strategies to prevent cryptococcal meningitis and its associated morbidity. ..
  62. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..