fructose

Summary

Summary: A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.

Top Publications

  1. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
  2. ncbi Metabolic effects of fructose and the worldwide increase in obesity
    Luc Tappy
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, CH 1005 Lausanne, Switzerland
    Physiol Rev 90:23-46. 2010
  3. pmc A fructose receptor functions as a nutrient sensor in the Drosophila brain
    Tetsuya Miyamoto
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
    Cell 151:1113-25. 2012
  4. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
  5. ncbi Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 79:537-43. 2004
  6. ncbi Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
  7. ncbi Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis
    John L Sievenpiper
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 156:291-304. 2012
  8. pmc The effects of fructose intake on serum uric acid vary among controlled dietary trials
    D David Wang
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, ON, Canada
    J Nutr 142:916-23. 2012
  9. ncbi Fructose and metabolic diseases: new findings, new questions
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Nutrition 26:1044-9. 2010
  10. ncbi Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    Mark J Dekker
    Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 299:E685-94. 2010

Detail Information

Publications308 found, 100 shown here

  1. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
    Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance...
  2. ncbi Metabolic effects of fructose and the worldwide increase in obesity
    Luc Tappy
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, CH 1005 Lausanne, Switzerland
    Physiol Rev 90:23-46. 2010
    While virtually absent in our diet a few hundred years ago, fructose has now become a major constituent of our modern diet. Our main sources of fructose are sucrose from beet or cane, high fructose corn syrup, fruits, and honey...
  3. pmc A fructose receptor functions as a nutrient sensor in the Drosophila brain
    Tetsuya Miyamoto
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
    Cell 151:1113-25. 2012
    ..imaging and behavioral assays, we show that the gustatory receptor 43a (Gr43a) functions as a narrowly tuned fructose receptor in taste neurons. Remarkably, Gr43a also functions as a fructose receptor in the brain...
  4. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
    We propose that excessive fructose intake (>50 g/d) may be one of the underlying etiologies of metabolic syndrome and type 2 diabetes. The primary sources of fructose are sugar (sucrose) and high fructose corn syrup...
  5. ncbi Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 79:537-43. 2004
    ..In this article, we investigate the relation between the intake of high-fructose corn syrup (HFCS) and the development of obesity...
  6. ncbi Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
    ..We revisit an old hypothesis that sugar, particularly excessive fructose intake, has a critical role in the epidemic of cardiorenal disease...
  7. ncbi Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis
    John L Sievenpiper
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 156:291-304. 2012
    The contribution of fructose consumption in Western diets to overweight and obesity in populations remains uncertain.
  8. pmc The effects of fructose intake on serum uric acid vary among controlled dietary trials
    D David Wang
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, ON, Canada
    J Nutr 142:916-23. 2012
    Hyperuricemia is linked to gout and features of metabolic syndrome. There is concern that dietary fructose may increase uric acid concentrations...
  9. ncbi Fructose and metabolic diseases: new findings, new questions
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Nutrition 26:1044-9. 2010
    There has been much concern regarding the role of dietary fructose in the development of metabolic diseases...
  10. ncbi Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    Mark J Dekker
    Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 299:E685-94. 2010
    As dietary exposure to fructose has increased over the past 40 years, there is growing concern that high fructose consumption in humans may be in part responsible for the rising incidence of obesity worldwide...
  11. pmc Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:4320-5. 2012
    b>Fructose intake from added sugars correlates with the epidemic rise in obesity, metabolic syndrome, and nonalcoholic fatty liver disease. Fructose intake also causes features of metabolic syndrome in laboratory animals and humans...
  12. pmc Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism
    John S White
    White Technical Research, Argenta, IL, USA
    Adv Nutr 4:246-56. 2013
    The field of sugar metabolism, and fructose metabolism in particular, has experienced a resurgence of interest in the past decade...
  13. pmc Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
    Kathleen A Page
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    JAMA 309:63-70. 2013
    Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance...
  14. ncbi Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials
    Vanessa Ha
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Hypertension 59:787-95. 2012
    Concerns have been raised about the adverse effect of fructose on blood pressure. International dietary guidelines, however, have not addressed fructose intake directly...
  15. ncbi Fructose, weight gain, and the insulin resistance syndrome
    Sharon S Elliott
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 76:911-22. 2002
    This review explores whether fructose consumption might be a contributing factor to the development of obesity and the accompanying metabolic abnormalities observed in the insulin resistance syndrome...
  16. pmc Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E1596-605. 2011
    ....
  17. ncbi Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes
    Kim Anne Le
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 89:1760-5. 2009
    ..Both nutritional and genetic factors are involved in the pathogenesis of nonalcoholic fatty liver disease and insulin resistance...
  18. ncbi Fructose and non-fructose sugar intakes in the US population and their associations with indicators of metabolic syndrome
    Sam Z Sun
    Office of Compliance and Ethics, Archer Daniels Midland Company, 1001 North Brush College Road, Decatur, IL 62521, USA
    Food Chem Toxicol 49:2875-82. 2011
    Relationships of sugar intakes with indicators of metabolic syndrome are important concerns for public health and safety. For individuals, dietary intake data for fructose and other sugars are limited.
  19. ncbi Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial
    Guenther Silbernagel
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Otfried Müller Straße 10, 72076 Tubingen, Germany
    Br J Nutr 106:79-86. 2011
    An increasing amount of fructose in the diet is suggested to play a causal role in the pathogenesis of the metabolic syndrome, type 2 diabetes and fatty liver...
  20. ncbi Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA
    Annu Rev Med 63:329-43. 2012
    ..There is less controversy concerning the effects of fructose on components of metabolic syndrome; consumption of fructose has been shown to increase visceral adipose ..
  21. pmc Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Adv Nutr 4:220-5. 2013
    ..Just less than 50% of the added sugars (sugar and high-fructose corn syrup) are found in soft drinks and fruit drinks...
  22. pmc 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition
    Rahul Agrawal
    Department of Integrative Biology and Physiology, University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Physiol 590:2485-99. 2012
    ..We report that high-dietary fructose consumption leads to an increase in insulin resistance index, and insulin and triglyceride levels, which ..
  23. ncbi A causal role for uric acid in fructose-induced metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 290:F625-31. 2006
    ..of metabolic syndrome correlates with an elevation in serum uric acid as well as a marked increase in total fructose intake (in the form of table sugar and high-fructose corn syrup)...
  24. pmc Fructose consumption as a risk factor for non-alcoholic fatty liver disease
    Xiaosen Ouyang
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    J Hepatol 48:993-9. 2008
    ..fatty liver disease (NAFLD) parallels the increase in obesity and diabetes, a significant increase in dietary fructose consumption in industrialized countries has also occurred...
  25. ncbi Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    Previous studies indicate that leptin secretion is regulated by insulin-mediated glucose metabolism. Because fructose, unlike glucose, does not stimulate insulin secretion, we hypothesized that meals high in fructose would result in lower ..
  26. pmc Fructose-fed rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes
    Andrew A Bremer
    Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
    Clin Transl Sci 4:243-52. 2011
    ..and we and others have proposed that this increase may at least in part be attributable to increased dietary fructose consumption...
  27. ncbi Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
    Astrid Spruss
    Department of Nutritional Medicine 180 a, University of Hohenheim, Stuttgart, Germany
    Hepatology 50:1094-104. 2009
    A link between dietary fructose intake, gut-derived endotoxemia, and nonalcoholic fatty liver disease (NAFLD) has been suggested by the results of human and animal studies...
  28. ncbi Fructose: metabolic, hedonic, and societal parallels with ethanol
    Robert H Lustig
    Division of Endocrinology, University of California, San Francisco, CA 94143 0434, USA
    J Am Diet Assoc 110:1307-21. 2010
    Rates of fructose consumption continue to rise nationwide and have been linked to rising rates of obesity, type 2 diabetes, and metabolic syndrome...
  29. ncbi Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men
    David Faeh
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Diabetes 54:1907-13. 2005
    High-fructose diet stimulates hepatic de novo lipogenesis (DNL) and causes hypertriglyceridemia and insulin resistance in rodents. Fructose-induced insulin resistance may be secondary to alterations of lipid metabolism...
  30. pmc Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:1562-9. 2009
    Compared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women...
  31. ncbi Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism
    Peter J Havel
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Nutr Rev 63:133-57. 2005
    b>Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity...
  32. pmc Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects
    Myphuong T Le
    Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    Metabolism 61:641-51. 2012
    It is unclear whether high-fructose corn syrup (HFCS), which contains a higher amount of fructose and provides an immediate source of free fructose, induces greater systemic concentrations of fructose as compared with sucrose...
  33. ncbi A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
    Kim Anne Le
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 84:1374-9. 2006
    High fructose consumption is suspected to be causally linked to the epidemics of obesity and metabolic disorders. In rodents, fructose leads to insulin resistance and ectopic lipid deposition...
  34. ncbi Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial
    Kishore M Gadde
    Obesity Clinical Trials Programme, Duke University Medical Center, Durham, NC 27710, USA
    Lancet 377:1341-52. 2011
    ....
  35. pmc Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    Laura H Tetri
    Department of Internal Medicine, Saint Louis University, MO, USA
    Am J Physiol Gastrointest Liver Physiol 295:G987-95. 2008
    ..to determine whether combining features of a western lifestyle in mice with trans fats in a high-fat diet, high-fructose corn syrup in the water, and interventions designed to promote sedentary behavior would cause the hepatic ..
  36. pmc Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance
    Lu Ping Ren
    Molecular Pharmacology for Diabetes Group, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Victoria, Australia
    PLoS ONE 7:e30816. 2012
    ..Male C57BL/6J mice were fed either a high fructose (HFru) or high fat (HFat) diet to induce DNL or lipid oversupply in/to the liver...
  37. pmc Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard
    George A Bray
    Pennington Biomedical Research Centre, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Diabetes Sci Technol 4:1003-7. 2010
    The worldwide consumption of sucrose, and thus fructose, has risen logarithmically since 1800...
  38. ncbi Consuming fructose-sweetened beverages increases body adiposity in mice
    Hella Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Obes Res 13:1146-56. 2005
    ..The marked increase in the prevalence of obesity in the United States has recently been attributed to the increased fructose consumption...
  39. ncbi Efficacy and safety of topiramate in the treatment of obese subjects with essential hypertension
    Serena Tonstad
    University of Oslo, Oslo, Norway
    Am J Cardiol 96:243-51. 2005
    ..In conclusion, topiramate produced clinically relevant effects in reducing body weight and BP, with generally mild to moderate adverse effects...
  40. ncbi Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin
    Ina Bergheim
    Department of Nutritional Medicine 180, University of Hohenheim, Fruwirthstrasse 12, 70599 Stuttgart, Germany
    J Hepatol 48:983-92. 2008
    ..The aim of the present study was to test the effects of ad libitum access to different sugars consumed in drinking water on hepatic fat accumulation...
  41. ncbi National estimates of dietary fructose intake increased from 1977 to 2004 in the United States
    Bernadette P Marriott
    Abt Associates Inc, Durham, NC 27703, USA
    J Nutr 139:1228S-1235S. 2009
    Our purpose was to conduct a new analysis to update and extend previously published trends of fructose availability and estimated fructose intake and food sources of dietary fructose from the 1977-1978 Nationwide Food Consumption Survey (..
  42. pmc Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO 80045, USA
    J Biol Chem 287:40732-44. 2012
    Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown.
  43. pmc Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
    The rising incidence of obesity and diabetes coincides with a marked increase in fructose consumption...
  44. ncbi The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
    Jung Sub Lim
    Department of Pediatrics, Korea Cancer Center Hospital, Gongneung dong 215, Nowon Gu, Seoul 139 706, Republic of Korea
    Nat Rev Gastroenterol Hepatol 7:251-64. 2010
    ..Secular trends in the prevalence of these diseases may be associated with the increased fructose consumption observed in the Western diet...
  45. ncbi High-fat, high-fructose diet induces hepatic iron overload via a hepcidin-independent mechanism prior to the onset of liver steatosis and insulin resistance in mice
    Hiroyuki Tsuchiya
    Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Misasagi Nakauchi cho 5, Yamashina ku, Kyoto, 607 8414, Japan
    Metabolism 62:62-9. 2013
    ..Decreased expression of hepcidin, a hepatic hormone that suppresses dietary iron absorption in the duodenum, is frequently observed in NAFLD patients and has been postulated to be a cause of HIO...
  46. pmc Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
    George A Kyriazis
    Metabolic Signaling and Disease, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Proc Natl Acad Sci U S A 109:E524-32. 2012
    ..We demonstrate that fructose activates sweet taste receptors (TRs) on beta cells and synergizes with glucose to amplify insulin release in ..
  47. ncbi Metabolic effects of fructose
    Kim Anne Le
    Department of Physiology, Faculty of Medicine, University of Lausanne, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 9:469-75. 2006
    b>Fructose is consumed in significant amounts in Western diets. An increase in fructose consumption over the past 10-20 years has been linked with a rise in obesity and metabolic disorders...
  48. ncbi Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans
    Fanny Theytaz
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 96:1008-16. 2012
    ..A high dietary protein intake has been shown to blunt the deposition of intrahepatic lipids in high-fat- and high-carbohydrate-fed rodents and humans...
  49. pmc Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials
    Adrian I Cozma
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 35:1611-20. 2012
    The effect of fructose on cardiometabolic risk in humans is controversial. We conducted a systematic review and meta-analysis of controlled feeding trials to clarify the effect of fructose on glycemic control in individuals with diabetes.
  50. pmc Fructose-rich beverages and risk of gout in women
    Hyon K Choi
    Section of Rheumatology and Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany St, Ste 200, Boston, MA 02118, USA
    JAMA 304:2270-8. 2010
    b>Fructose-rich beverages such as sugar-sweetened soda and orange juice can increase serum uric acid levels and, thus, the risk of gout, but prospective data on the relationship are limited.
  51. ncbi A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects
    J Wilding
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Int J Obes Relat Metab Disord 28:1399-410. 2004
    ..Treatment of obese subjects with topiramate has recently been associated with significant weight loss in a 6-month dose-ranging study...
  52. pmc Fructose and cardiometabolic disorders: the controversy will, and must, continue
    Nicolas Wiernsperger
    INSERM U, INSA Lyon, Villeurbanne, France
    Clinics (Sao Paulo) 65:729-38. 2010
    The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate...
  53. ncbi The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension
    Linda T Tran
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Mol Cell Biochem 332:145-59. 2009
    ..The fructose-fed rat is an animal model of acquired systolic hypertension that displays numerous features of the metabolic ..
  54. ncbi Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction
    Zvi Ackerman
    Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Hypertension 45:1012-8. 2005
    ..in liver pathology, hepatic lipid composition, and hepatic iron concentration (HIC) occurring in rats given fructose-enriched diet (FED), with and without therapeutic maneuvers to reduce blood pressure and plasma triglycerides...
  55. pmc Fructose consumption: recent results and their potential implications
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Ann N Y Acad Sci 1190:15-24. 2010
    ..evidence that additional research is needed to determine the adverse effects of consuming added sugars containing fructose. Current guidelines recommend limiting sugar consumption in order to prevent weight gain and promote nutritional ..
  56. ncbi Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women
    Kathleen J Melanson
    Department of Nutrition and Food Sciences, University of Rhode Island, Kingston, Rhode Island, USA
    Nutrition 23:103-12. 2007
    b>Fructose has been implicated in obesity, partly due to lack of insulin-mediated leptin stimulation and ghrelin suppression...
  57. ncbi Effects of dietary fructose on plasma lipids in healthy subjects
    J P Bantle
    Department of Medicine, the General Clinical Research Center, The Division of Biostatistics, and the School of Public Health, The University of Minnesota, Minneapolis, MN 55455, USA
    Am J Clin Nutr 72:1128-34. 2000
    About 9% of average dietary energy intake in the United States comes from fructose. Such a high consumption raises concern about the metabolic effects of this sugar.
  58. ncbi Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
    ..In conclusion, increased AR activity contributes to retinal oxidative stress and VEGF protein overexpression in early diabetes. The findings justify the rationale for evaluation of fidarestat on diabetic retinopathy...
  59. pmc Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme
    Christine P Diggle
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, United Kingdom
    J Histochem Cytochem 57:763-74. 2009
    Ketohexokinase (KHK, also known as fructokinase) initiates the pathway through which most dietary fructose is metabolized. Very little is known about the cellular localization of this enzyme...
  60. pmc A high fructose diet impairs spatial memory in male rats
    A P Ross
    Department of Psychology, Georgia State University, Atlanta, GA 30302 5030, USA
    Neurobiol Learn Mem 92:410-6. 2009
    Over the past three decades there has been a substantial increase in the amount of fructose consumed by North Americans...
  61. pmc High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels
    Miriam E Bocarsly
    Department of Psychology, Princeton University, Princeton, NJ 08540, USA
    Pharmacol Biochem Behav 97:101-6. 2010
    High-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Some studies have shown that short-term access to HFCS can cause increased body weight, but the findings are mixed...
  62. ncbi Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans
    J Q Purnell
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Diabetes Obes Metab 13:229-34. 2011
    In animals, intracerebroventricular glucose and fructose have opposing effects on appetite and weight regulation...
  63. ncbi High fructose corn syrup and diabetes prevalence: a global perspective
    Michael I Goran
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Glob Public Health 8:55-64. 2013
    ..study was to evaluate, from a global and ecological perspective, the relationships between availability of high fructose corn syrup (HFCS) and prevalence of type 2 diabetes...
  64. ncbi Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats
    Hariom Yadav
    Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana, India
    Nutrition 23:62-8. 2007
    We investigated the effect of low-fat (2.5%) dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei on progression of high fructose-induced type 2 diabetes in rats.
  65. ncbi Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats
    Pankaj K Bagul
    Division of Pharmacology and Chemical Biology, Indian Institute of Chemical Technology, Hyderabad 500607, India
    Pharmacol Res 66:260-8. 2012
    ..supplement, can improve insulin sensitivity, metabolic complication as well as hepatic oxidative stress in fructose-fed rats. Male Sprague Dawley rats (180-200 g) were divided into four groups with 8 animals each...
  66. pmc Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
    Manal F Abdelmalek
    Division of Gastroenterology and Hepatology, Duke University, Durham, NC 27710, USA
    Hepatology 56:952-60. 2012
    b>Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD)...
  67. ncbi Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance
    Dingzhen Luo
    Department of Senile Neurology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, PR China
    Eur J Pharmacol 664:14-9. 2011
    ..In this study we examined the role of dietary conditions leading to insulin resistance on amyloidosis in fructose-drinking rats...
  68. ncbi The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial
    Magdalena Madero
    Division of Nephrology, Department of Medicine, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, Tlalpan, Mexico City, Mexico
    Metabolism 60:1551-9. 2011
    ..of obesity and metabolic syndrome is the excessive intake of products containing added sugars, in particular, fructose. Although the ability of excessive intake of fructose to induce metabolic syndrome is mounting, to date, no study ..
  69. ncbi A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana Baylor Hospital, Dallas, Texas, USA
    Obes Res 11:722-33. 2003
    ..To evaluate the efficacy and safety of topiramate (TPM) for weight loss in healthy obese subjects...
  70. ncbi Bladder dysfunction in rats with metabolic syndrome induced by long-term fructose feeding
    Wei Chia Lee
    Division of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China
    J Urol 179:2470-6. 2008
    We studied the effects of long-term fructose feeding and metabolic perturbations on bladder function in rats.
  71. ncbi Fructose might contribute to the hypoglycemic effect of honey
    Omotayo O Erejuwa
    Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    Molecules 17:1900-15. 2012
    ..Nevertheless, available evidence indicates that honey consists of predominantly fructose and glucose...
  72. ncbi Nocturnal hypertension in mice consuming a high fructose diet
    Vera Farah
    Boonshoft School of Medicine of Wright State University, Department of Pharmacology and Toxicology, Dayton, OH 45401, USA
    Auton Neurosci 130:41-50. 2006
    To investigate the effect of fructose consumption on the light/dark pattern of blood pressure, heart rate and autonomic neural function in mice.
  73. pmc Dietary fructose causes tubulointerstitial injury in the normal rat kidney
    Takahiro Nakayama
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F712-20. 2010
    ..We previously reported that a high-fructose diet, but not a high-glucose diet, can induce metabolic syndrome and accelerate chronic renal disease in rats...
  74. ncbi Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats
    Roberto Miatello
    Department of Pathology, School of Medicine, Universidad Nacional de Cuyo, Institute of Experimental Medicine and Biology of Cuyo CONICET, Mendoza, Argentina
    Am J Hypertens 18:864-70. 2005
    ..study examined the effect of chronic administration of RV on endothelial nitric oxide synthase (eNOS) activity in cardiovascular tissues and on plasma lipid peroxidation in fructose-fed rats (FFR), an experimental model of this syndrome.
  75. pmc Increased fructose associates with elevated blood pressure
    Diana I Jalal
    Division of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, 12700 E 19th Avenue, Research 2, C281, Aurora, CO 80045, USA
    J Am Soc Nephrol 21:1543-9. 2010
    The recent increase in fructose consumption in industrialized nations mirrors the rise in the prevalence of hypertension, but epidemiologic studies have inconsistently linked these observations...
  76. ncbi Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate
    Pamela L Follett
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:4412-20. 2004
    ....
  77. ncbi Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats
    Nuria Roglans
    Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona and IBUB Institute of Biomedicine University of Barcelona, Barcelona, Spain
    Hepatology 45:778-88. 2007
    b>Fructose makes up a significant proportion of energy intake in westernized diets; its increased consumption has paralleled the growing prevalence of obesity and metabolic syndrome over the past two decades...
  78. ncbi Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat
    Sandrine Delbosc
    Laboratoire de Nutrition Humaine et Athérogenèse, Institut Universitaire de Recherche Clinique, 34093 Montpellier, France
    Atherosclerosis 179:43-9. 2005
    Growing evidences suggest a role of oxidative stress in hypertension and cardiac hypertrophy. The fructose (60%)-fed rat represents a model of metabolic syndrome, associating insulin resistance and high blood pressure...
  79. ncbi Alterations of M2,3-muscarinic receptor protein and mRNA expression in the bladder of the fructose fed obese rat
    Yat Ching Tong
    Department of Urology, School of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Urol 178:1537-42. 2007
    The effects of metabolic syndrome on bladder function and M2,3-muscarinic receptor expression were studied using the fructose fed obese rat.
  80. ncbi Fructose malabsorption is associated with decreased plasma tryptophan
    M Ledochowski
    Dept of Clinical Nutrition, Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Scand J Gastroenterol 36:367-71. 2001
    b>Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid...
  81. pmc Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats
    Shan Shan Xing
    Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China
    Mol Med 16:465-70. 2010
    ..of interleukin (IL)-18 could aggravate left ventricular (LV) remodeling and diastolic dysfunction in fructose-fed rats (FFRs). To create an animal model for MS, male Wistar rats received 10% fructose in water for 8 months...
  82. ncbi Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism
    Laia Vilà
    Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona, Barcelona, Spain
    Hepatology 48:1506-16. 2008
    There is controversy regarding whether fructose in liquid beverages constitutes another dietary ingredient of high caloric density or introduces qualitative changes in energy metabolism that further facilitate the appearance of metabolic ..
  83. ncbi Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats
    YiQing Liu
    Department of Pediatrics, University of Michigan, Ann Arbor, Mich, USA
    Stroke 35:1460-5. 2004
    ..We evaluated whether treatment with topiramate, a clinically available anticonvulsant, increased the efficacy of delayed post-HI hypothermia in a neonatal rat stroke model...
  84. ncbi Topiramate in the treatment of migraine: a kainate (glutamate) receptor antagonist within the trigeminothalamic pathway
    Anna P Andreou
    Headache Group, University of California, San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA
    Cephalalgia 31:1343-58. 2011
    ..Since glutamate plays a major role in migraine pathophysiology, the potential action of topiramate through glutamatergic mechanisms is of considerable interest...
  85. pmc Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 94:112-9. 2011
    ..It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweetened beverages are a consequence of increased circulating glucose and insulin excursions, ie, dietary glycemic index (GI)...
  86. ncbi Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1 subunit phosphorylation in astrocytes from primary cultures
    Mikael Angehagen
    Institute of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurochem 94:1124-30. 2005
    ..Furthermore, it was shown that TPM binds to AMPA receptors in the dephosphorylated state and thereby exerts an allosteric modulatory effect on the ion channel...
  87. ncbi Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus
    Hyun Young Koo
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 390:285-9. 2009
    Diets high in fructose cause hypertriglyceridemia and insulin resistance in part due to simultaneous induction of gluconeogenic and lipogenic genes in liver...
  88. ncbi Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement
    Qing Hua Hu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Am J Physiol Renal Physiol 297:F1080-91. 2009
    b>Fructose consumption has been recently related to an epidemic of metabolic syndrome, and hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome...
  89. ncbi Parametrial adipose tissue and metabolic dysfunctions induced by fructose-rich diet in normal and neonatal-androgenized adult female rats
    Ana Alzamendi
    Neuroendocrine Unit, IMBICE CONICET CICPBA, La Plata, Argentina
    Obesity (Silver Spring) 18:441-8. 2010
    ..The aim of our study was to evaluate endocrine and metabolic effects during early allostasis induced by a fructose-rich diet (FRD) in normal (control; CT) and neonatal-androgenized (testosterone propionate; TP) female adult rats...
  90. ncbi Fructose transporter GLUT5 expression in clear renal cell carcinoma
    V Medina Villaamil
    INIBIC, CHU A Coruña, Oncology Group, Department of Pathology, Xubias de Abaixo s n, 15006 A Coruna, Spain
    Oncol Rep 25:315-23. 2011
    ..These data suggest a role for the GLUT5 isoform in fructose uptake that takes place in cRCC cells and which subsequently leads to the malignant RCC progression.
  91. ncbi Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats
    Bárbara Maiztegui
    CENEXA Centro de Endocrinología Experimental y Aplicada UNLP CONICET LA PLATA, Centro Colaborador OPS OMS, Facultad de Ciencias Médicas UNLP, La Plata, Argentina
    Clin Sci (Lond) 120:73-80. 2011
    ..sitagliptin and exendin-4 upon metabolic alterations, β-cell mass decrease and hepatic steatosis induced by F (fructose) in rats...
  92. ncbi Phentermine/topiramate for weight reduction and treatment of adverse metabolic consequences in obesity
    H E Bays
    L MARC Research Center, Louisville, Kentucky 40213, USA
    Drugs Today (Barc) 47:903-14. 2011
    ..Reported adverse events with this combination agent are as expected, based upon knowledge of the individual components...
  93. ncbi Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats
    Wannaporn Suwannaphet
    Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
    Food Chem Toxicol 48:1853-7. 2010
    ..the preventive effect of grape seed extract (GSE) on insulin resistance and oxidative stress in rats fed a high-fructose diet...
  94. ncbi Topiramate as add-on treatment for patients with bipolar mania
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15215 2593, USA
    Bipolar Disord 1:42-53. 1999
    ..Topiramate (Topamax), a new antiepileptic agent, is a candidate drug for bipolar disorder. We evaluated topiramate as adjunctive treatment for bipolar patients...
  95. ncbi Exogenous carbohydrate oxidation rates are elevated after combined ingestion of glucose and fructose during exercise in the heat
    Roy L P G Jentjens
    Human Performance Labaratory, School of Sport and Exercise Sciences, Univ of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    J Appl Physiol 100:807-16. 2006
    The first purpose of this study was to investigate whether a glucose (GLU)+fructose (FRUC) beverage would result in a higher exogenous carbohydrate (CHO) oxidation rate and a higher fluid availability during exercise in the heat compared ..
  96. ncbi Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice
    Giridhar Kanuri
    Department of Nutritional Medicine 180 a, University of Hohenheim, 70599 Stuttgart, Germany
    J Nutr Biochem 22:527-34. 2011
    ..However, whether TNFα also plays a casual role in the onset of fructose-induced nonalcoholic fatty liver disease (NAFLD) has not yet been determined...
  97. ncbi Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation
    Xueping Liu
    Department of Senile Neurology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250021, PR China
    Eur J Pharmacol 629:153-8. 2010
    ..agonist, pioglitazone, on cognition function and AGE/RAGE system in a rodent model of insulin resistance, the fructose-drinking rats...
  98. ncbi The mechanism of neuroprotection by topiramate in an animal model of epilepsy
    Alexei P Kudin
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 45:1478-87. 2004
    ..For the antiepileptic drug (AED) topiramate (TPM), neuroprotective effects have been reported in models of focal cerebral ischemia and experimental status epilepticus, but the putative mechanism of action has remained elusive...
  99. ncbi Exogenous carbohydrate oxidation during ultraendurance exercise
    Asker E Jeukendrup
    Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Appl Physiol (1985) 100:1134-41. 2006
    ..5 h of exercise; and 2) to compare CHO(Exo) following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise...
  100. ncbi Abdominal adipose tissue: early metabolic dysfunction associated to insulin resistance and oxidative stress induced by an unbalanced diet
    O R Rebolledo
    CENEXA Center of Experimental and Applied Endocrinology National University of La Plata National Research Council, PAHO WHO Collaborating Center, 60 y 120 La Plata, Argentina
    Horm Metab Res 40:794-800. 2008
    ..changes in lipid composition, function, and antioxidant status of abdominal adipose tissue (AAT) induced by a fructose-rich diet (FRD) to the development of insulin resistance (IR) and oxidative stress (OS) was studied...
  101. ncbi Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats
    Xi Wang
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Eur J Pharmacol 555:48-53. 2007
    ..of treatment with BH4 on endothelium-dependent relaxation and adiponectin levels during oxidative stress in fructose-fed rats, which provide an animal model for the metabolic syndrome...

Research Grants64

  1. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..ability of betaine to reverse hepatic steatosis in two rodent metabolic syndrome models: Zucker (fa/fa) rats and fructose-fed apobec-1-/- mice (B100)...
  2. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ..2- Fructose consumption has differential effects when compared to glucose on the functional connections between the ..
  3. OLIGOCLONAL T CELL EXPANSION AND RHEUMATOID ARTHRITIS
    Cornelia M Weyand; Fiscal Year: 2012
    ..Specifically, we will examine how insufficient induction of the regulatory enzyme 6-phospofructo-2-kinase/fructose-2,6- biphosphatase in RA CD4 T cells reduces glycolytic flux and renders T cells apoptosis sensitive...
  4. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..One likely contributor to the etiology of metabolic syndrome is fructose. The secular trend in fructose consumption parallels the triple epidemics of obesity, type 2 diabetes, and ..
  5. Mechanisms of diet-induced leptin resistance in ARC and VTA
    Philip J Scarpace; Fiscal Year: 2013
    ..Our data demonstrate that a low-fat diet with elevated fructose causes leptin resistance, whereas diets without fructose do not...
  6. A novel role for endogenous fructose in ischemic acute kidney injury
    MIGUEL ANGEL LANASPA GARCIA; Fiscal Year: 2013
    ..Aldose reductase converts glucose to sorbitol while sorbitol dehydrogenase metabolizes sorbitol to fructose. Our preliminary data in mice with ischemic acute kidney injury demonstrate that there is a significant ..
  7. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..Aim 1: Our hypothesis predicts that high fructose and high fat diet will increase thickness and the inflammatory phenotype of EAT accompanied with impairment of ..
  8. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ..we will determine if MR reverses pre-existing obesity, fatty liver and insulin resistance in mice after a high fructose diet...
  9. Metabolic Pathways and Defects in Fructose Metabolism
    DEAN TOLAN; Fiscal Year: 2009
    Long-term ingestion has effects on diabetes and obesity. The most drastic and common genetic disorder of fructose metabolism is hereditary fructose intolerance (HFI)...
  10. Development of inhibitors of AMP Deaminase Isoform 2 as a Mechanism for Treating
    RICHARD JOSEPH JOHNSON; Fiscal Year: 2010
    ..in high uric acid, which we have found further up-regulates AMPD2, and second, because of the marked intake of fructose present in added sugars of the human diet that also stimulates AMPD2 along with providing substrate...
  11. Cellular Mechanisms for Increased Gluconeogenesis in Type 2 Diabetes
    Varman T Samuel; Fiscal Year: 2013
    ..g. acyl-CoA's, diacylglycerol) by LC-MS/MS. We will also quantify changes in de novo lipogenesis in fructose-fed rats treated with either PEPCK ASO or PC ASO and assess the changes in NAFLD and hepatic insulin resistance...
  12. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..vitamin B6, vitamin B12, zinc;and 3) glycemic control - dietary glycemic load;intake of glucose, sucrose, fructose, fiber. For our second Aim, we will consider the HPA axis pathway...
  13. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..insulin action in the liver, hypoglycemic counterregulation and the deleterious effect of a diet high in fat and fructose on hepatic metabolism...
  14. Nutrition and Physical Activity Assessment Study (NPAAS)
    Ross L Prentice; Fiscal Year: 2013
    ..We will obtain 24-h urine-derived nutritional measures, including nitrogen (protein), fructose, sucrose (sugars), alkylresorcinols (whole grains) and 1- and 3- methylhistidine (meat);and blood-derived ..
  15. Targeting Glucose Metabolism in Cancer
    Sucheta Telang; Fiscal Year: 2013
    ..loss of p53 function stimulate glycolysis by activating a family of four bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB) which synthesize fructose-2,6-bisphosphate (F2,6BP), an allosteric activator of 6-..
  16. EFFECT OF HIGH FRUCTOSE CORN SYRUP FEEDING IN NONALCOHOLIC FATTY LIVER DISEASE
    Shelby A Sullivan; Fiscal Year: 2013
    ..of the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) in relation to consumption of an increased high fructose corn syrup diet in obese persons without NAFLD compared to obese persons with NAFLD. Dr...
  17. Role of mesenteric lymphatics and dietary endotoxin in metabolic syndrome
    DAVID CARL ZAWIEJA; Fiscal Year: 2013
    ..We have recently shown that high fructose diet-induced metabolic syndrome (MetSyn) rats exhibit impaired mesenteric lymphatic function...
  18. Prenatal exposure to high-fat diets promotes alcohol preference in the offspring
    Miriam E Bocarsly; Fiscal Year: 2012
    ..Our laboratory finds that animals maintained on a diet with free access to high-fructose corn syrup show significantly elevated TG levels, as compared to controls. Therefore (Exp...
  19. Regulation of Food Intake via the Glucagon-Like Peptide-1 Receptor
    Julio E Ayala; Fiscal Year: 2013
    ..Contrasting the effects of glucose, central administration of fructose attenuates the anorectic effect of Ex4. Fructose activates hypothalamic AMPK...
  20. Giardia drug targets: Structure, function and inhibitors
    Osnat Herzberg; Fiscal Year: 2010
    ..During the next phase of the project we will study three enzymes;fructose-1,6-biphosphate aldolase of the glycolytic pathway, carbamate kinase of the arginine dihydrolase pathway, and a ..
  21. Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
    Jean Marc Schwarz; Fiscal Year: 2013
    ..for 2 weeks in young (18-40 years), normal weight and overweight/obese adults (5R01HL091333-02: Effects of 2wk fructose &HFCS consumption on lipid dysregulation &insulin resistance)...
  22. Activation of Cyclin-Dependent Kinases by Fructose-2,6-Bisphosphate
    JASON A CHESNEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB) phosphorylate fructose-6-phosphate (F6P) to fructose-2,6-bisphosphate (F2,6BP), which is an allosteric activator of 6-phosphofructo-1-..
  23. Targeting of 6-Phosphofructo-2 kinase in Cancer
    Jason Chesney; Fiscal Year: 2009
    ..cancers and each of these genetic alterations converge on glycolysis by activating the 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatases (PFKFB)...
  24. Liver Glucose Flux in Obesity and Diabetes
    Masakazu Shiota; Fiscal Year: 2013
    ..whether glucotoxicity alters the binding affinity between GK and GKRP and/or GK and 6-phosphofructose-2-kinase/fructose-2, 6-phosphatase (a cytoplasmic binding protein partner) by altering the phosphorylation status of these proteins...
  25. Refined Fructose Promotes Pancreatic Cancer Growth
    Anthony P Heaney; Fiscal Year: 2011
    ..Specifically, the consumption of fructose has increased dramatically, primarily because of increased consumption of beverages that are high in fructose and ..
  26. Potassium Channel Dysfunction in Cerebral Arteries
    David W Busija; Fiscal Year: 2013
    ..in cerebral arteries from SD rats suffering from insulin resistance due to consumption of a diet high in fructose. Third, we will elucidate the mechanisms of altered responses in aged and insulin resistant animals...
  27. Effect of Atypical Antipsychotics on Fructose Metabolism and Weight Gain
    CAROLINE PALAVICINO-MAGGIO; Fiscal Year: 2012
    ..In this R36 project, I propose a novel hypothesis that antipsychotics induce weight gain by altering fructose absorption and metabolism in the intestine...
  28. Effects of 2wk fructose &HFCS consumption on lipid dysregulation &insulin resis
    Peter J Havel; Fiscal Year: 2012
    Project Summary: We are conducting an ongoing study comparing the effects of 10 weeks of fructose or glucose consumption at 25% of energy requirements on lipid parameters and indices of insulin resistance and inflammation in older (+40 ..
  29. Synthetic glycopeptide vaccines that enhance resistance to candidiasis
    Hong Xin; Fiscal Year: 2013
    ..albicans cell surface protein fructose bisphosphate aldolase) and C...
  30. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    ..Recent studies from our laboratories demonstrate novel interactions between carbohydrates (glucose and fructose) and DRA, PAT1, and NHE3 in the intestine and kidney tubules...
  31. Dietary Fructose and Redox Effects in Pediatric Nonalcoholic Fatty Liver Disease
    MIRIAM BENEDICTA VOS; Fiscal Year: 2012
    ..sweetener consumption has increased dramatically over the past 3 decades resulting in higher daily consumption of fructose, a monosaccharide that is metabolized primarily in the liver...
  32. De novo lipogenesis in the pathogenesis of non-alcoholic fatty liver disease
    Jean Marc Schwarz; Fiscal Year: 2010
    ..can vary dramatically depending on the diet and/or health status of a subject;and, in particular, that dietary fructose is a potent lipogenic stimulus...
  33. Dietary fructose and low-grade inflammation
    Mario Kratz; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The objective of this proposal is to investigate whether fructose-sweetened beverages trigger low-grade systemic inflammation in healthy men and women...
  34. Efficacy Of Metformin In The Methylnitrosourea-Induced Model Of ER
    Terisa Davis; Fiscal Year: 2013
    ..on mammary cancer incidence and multiplicity in rats fed either a standard diet, a high fat diet, or a high fructose diet...
  35. PROINFLAMMATORY ROLE OF URIC ACID IN LUNG DISEASE: NOVEL MODELS AND CLINICAL VALI
    Richard M Wright; Fiscal Year: 2013
    ..These experiments will be contrasted to mice made hyperuricemic by fructose feeding. ALI/ARDS will be induced using Th1 cytokine or LPS insufflation subsequent to XOR ablation...
  36. ACE Balance in the Cardiovascular Complications of Diabetes
    Mariana Morris; Fiscal Year: 2012
    ..Our studies in dietary (fructose feeding) and genetic (leptin receptor mutant, db/db) models of insulin resistance show that there is increased ..
  37. Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD
    Brian J Soher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): To define the mechanism(s) by which fructose may contribute to nonalcoholic fatty liver disease (NAFLD) progression and assess whether such factors can be measured using magnetic resonance (MR) ..
  38. How glucose transporter structure affects its function
    Anthony Carruthers; Fiscal Year: 2013
    ..GLUT1 transports glucose but not fructose while GLUT5 transports fructose not glucose...
  39. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    ..This effect could be mediated by increased levels of fructose-2,6-bisphosphate in the cochlea...
  40. Targeting persistent M. tuberculosis through the inhibition of its aldolase
    Mary Jackson; Fiscal Year: 2010
    ..The search for alternative drug therapies has led to our interest in class II fructose-1,6-bisphosphate aldolase (FBA), a key enzyme of glycolysis/gluconeogenesis that was shown to be induced in M...
  41. Identification of novel therapeutics for tuberculosis combining cheminformatics,
    Sean Ekins; Fiscal Year: 2013
    ..marrying the cheminformatic and pathways database that resulted in two compounds as proposed mimics of 2 D-fructose 1,6 bisphosphate with activity against Mtb (MIC 20 and 40mg/ml)...
  42. Hyperpolarized 13C Markers of Diabetic Nephropathy and Treatment Response
    Zhen Jane Wang; Fiscal Year: 2013
    ..HP probes: (1) the redox sensor HP 13C-dehydroascorbate (DHA), an oxidized version of Vitamin C, and (2) HP 13C-fructose, a hexose probe that evaluates the early steps of glycolysis...
  43. Metabolic Markers of Carbonyl, Oxidative and Nitrosative Stress in the DCCT/EDIC
    Vincent M Monnier; Fiscal Year: 2013
    ..e. 2 glycation products (fructose-lysine and glucose pane), 2 glycoxidation products (carboxymethyl-lyinse (CML) and carboxyethyl-lysine (CEL), 2 ..
  44. Hyperandrogenemia, Diet and Female Reproductive Health
    Richard L Stouffer; Fiscal Year: 2013
    ..effects of excess androgen exposure and metabolic changes due to a typical Western-style diet (WSD, high fat and fructose content) on: (1) the hypothalamus-pituitary-ovary-reproductive tract axis, as well as adipose tissue;(2) the ..
  45. Ascorbate-based biomarkers for predicting radiation response in prostate cancer
    David Wilson; Fiscal Year: 2013
    ..13C agents have been developed that are potential markers for pH (13C bicarbonate), hexose metabolism ([2-13C] fructose), and necrosis ([1,4-13C] fumarate)...
  46. Inhibitors Against Trypanosomatid Pyruvate Kinases
    MALCOLM DOUGLAS WALKINSHAW; Fiscal Year: 2012
    ..or R-state) conformation not only corresponds to the predominant conformation in vivo (for example, fructose bisphosphate levels are normally saturating in T...
  47. Assay Development of M. tuberculosis class II aldolase
    Mary Jackson; Fiscal Year: 2010
    ..The search for alternative drug therapies has led to our interest in class II fructose-1, 6-bisphosphate aldolase (FBA), a key enzyme of glycolysis/gluconeogenesis that was shown to be induced in M...
  48. Biomarkers of Dietary Variables Commonly Misreported
    Megan A McCrory; Fiscal Year: 2010
    ..We will test our hypotheses by assessing a combination of novel (urinary sucrose + fructose for foods high in sugar) and established (plasma carotenoids and serum phylloquinone for fruits and vegetables) ..
  49. CYTOSOLIC-VESICLE-VACUOLAR PROTEIN DEGRADATION PATHWAY
    Hui Ling Chiang; Fiscal Year: 2010
    ..The gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase) is degraded when yeast cells are shifted from poor carbon sources to fresh glucose, ..
  50. MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
    Milton Saier; Fiscal Year: 2000
    ..2) propose an allosteric mechanism by which adenylate cyclase is regulated by the PTS; (3) demonstrate that the fructose repressor (FruR) mediates cAMP- independent catabolite activation/repression, regulating transcription of ..
  51. STRUCTURAL AND FUNCTIONAL ANALYSIS OF GLUCOSE TRANSPORTERS
    Jun Yong Choe; Fiscal Year: 2013
    ..GLUT carries carbohydrates (glucose, fructose, galactose and others), major energy sources for living cells, across membranes...
  52. Metabolic Oscillations in Pancreatic Beta-Cells
    Matthew J Merrins; Fiscal Year: 2012
    ..the DOM at the level of metabolic activity, we propose to examine whether glucokinase and phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB), which are regulators of PFK1, represent oscillatory parameters that modulate ..
  53. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..examine the influence of the duration of the diabetic state on vagal and sciatic nerve concentrations of glucose, fructose, sorbitol, myoinositol, and Na+-K+-ATPase activity...
  54. Risk Factors for Gout Among Women
    Hyon Choi; Fiscal Year: 2009
    ..examine the relations with novel risk factors of gout: 1) increased risk with sugar-sweetened soft drinks and fructose consumption;2) decreased risk with coffee intake;and 3) decreased risk with vitamin C consumption...
  55. NUTRITIONAL EFFECTS OF SUGARS ON LIVER LIPIDS
    CHARLES SPARKS; Fiscal Year: 1990
    ..diets, sucrose as a carbohydrate source results in hyperlipoproteinemia in excess of that of dietary glucose or fructose. In the sucrose model significant hypercholesterolemia and hypertriglyceridemia occur followed by early ..
  56. CHITIN BIOSYNTHESIS AND THE MOSQUITO PERITROPHIC MATRIX
    Bruce Christensen; Fiscal Year: 2007
    ..It now is known that glutamine synthetase (GS), glucosamine: fructose-6-phosphate amidotransferase (GFAT) and chitin synthase (CS) play major roles in chitin synthesis in the midgut...
  57. Identification of anti-cariogenic/low-glycemic activity factors from Lo Han Kuo
    CHIFU HUANG; Fiscal Year: 2006
    ..that are commercially available, designed to provide zero- or low-calorie artificial alternatives to sucrose/high fructose corn syrup, there remain concerns regarding potential health concerns in the general population or unique subsets ..
  58. FRUCTOFURANOSE MODULATORS--STRUCTURAL/ENZYMATIC STUDIES
    EZZAT YOUNATHAN; Fiscal Year: 1992
    ..Scores of enzymes were shown to have allosteric sites for fructose 1,6- and 2,6-bisphosphates...
  59. DEVELOPMENTAL CHANGES IN HEART AND MUSCLE PFK ISOZYMES
    George Dunaway; Fiscal Year: 1991
    ..regulate 6-phosphofructo-1-kinase (PFK) isozymes during development and also to better understand the role of fructose-2, 6-bisphosphate (fructose-2, 6-P2) during development...
  60. The presence of a bacterial metabolic pathway in eukaryotic fungi
    KERRY SCOT SMITH; Fiscal Year: 2010
    ..provided by applicant): A bacterial metabolic pathway composed of acetate kinase (ACK) and xylulose 5- phosphate/fructose 6-phosphate phosphoketolase (XFP) has been identified in eukaryotic fungi...
  61. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
    The bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase plays a crucial role in glucose metabolism...
  62. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..Another important enzyme for regulation of gluconeogenesis is 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (6PF2K/FBPase), which is responsible for the production and hydrolysis of fructose-2,6-..
  63. HUMAN PFK ISOZYMES: BIOCHEMICAL AND GENETIC STUDIES
    Alan McLachlan; Fiscal Year: 1993
    Phosphofructokinase (ATP:D-fructose-6-phosphate 1-phosphotransferase, EC 2.7.1.11;PFK) is a key regulatory enzyme of glycolysis...
  64. TREATMENT OF ARDS WITH FRUCTOSE DIPHOSPHATE
    ANGEL MARKOV; Fiscal Year: 1991
    This proposal is concerned with the evaluation of the therapeutic effectiveness of Fructose-1,6-diphosphate Sodium Salt (FDP) in patients with Adult Respiratory Distress Syndrome (ARDS)...