heptoses

Summary

Top Publications

  1. ncbi The occurrence of glycine in bacterial lipopolysaccharides
    A Gamian
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Czerska, Wroclaw, Poland
    FEMS Immunol Med Microbiol 13:261-8. 1996
  2. ncbi Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d
    Hua Wang
    Department Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 47:710-20. 2008
  3. ncbi Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses
    Andrey V Karlyshev
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WCIE 7HT, UK
    Mol Microbiol 55:90-103. 2005
  4. ncbi Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide
    Roberta Marchetti
    Dipartimento di Scienze Chimiche, Universita di Napoli Federico II, Italy
    Glycobiology 22:1387-98. 2012
  5. ncbi Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase
    Nicolas Desroy
    MUTABILIS SA, 102 Avenue Gaston Roussel, 93230 Romainville, France
    Bioorg Med Chem 17:1276-89. 2009
  6. ncbi Highly efficient synthesis of ketoheptoses
    Daniel Waschke
    University of Hamburg, Faculty of Science, Department of Chemistry, Martin Luther King Platz 6, 20146 Hamburg, Germany
    Org Lett 13:3628-31. 2011
  7. pmc The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose
    M A Valvano
    Department of Microbiology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Bacteriol 182:488-97. 2000
  8. ncbi The mechanism of the reaction catalyzed by ADP-beta-L-glycero-D-manno-heptose 6-epimerase
    Jay A Read
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Chem Soc 126:8878-9. 2004
  9. ncbi Efficient chemical synthesis of both anomers of ADP L-glycero- and D-glycero-D-manno-heptopyranose
    Alla Zamyatina
    Institute of Chemistry, University of Agricultural Sciences, Muthgasse 18, A 1190 Vienna, Austria
    Carbohydr Res 338:2571-89. 2003
  10. ncbi A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant
    C Michael Reynolds
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:21202-11. 2005

Research Grants

  1. Glycosylation of Campylobacter flagella
    Patricia Guerry; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. ncbi The occurrence of glycine in bacterial lipopolysaccharides
    A Gamian
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Czerska, Wroclaw, Poland
    FEMS Immunol Med Microbiol 13:261-8. 1996
    ..Molar ratio of glycine in core oligosaccharide fraction ranged from 0.2 to 0.6 per 3 heptoses. The oligosaccharide enriched in glycine was isolated using the HPLC...
  2. ncbi Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d
    Hua Wang
    Department Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 47:710-20. 2008
    ..The lectin activity of hNCRDs was inhibited by specific heptoses, including l-glycero-alpha-d-manno-heptose (l,d-heptose), but not by 3-deoxy-alpha-d-manno-oct-2-ulosonic acid (..
  3. ncbi Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses
    Andrey V Karlyshev
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WCIE 7HT, UK
    Mol Microbiol 55:90-103. 2005
    ..Furthermore, we show the retention of two functional heptose isomerases in Campylobacter and the sharing of a phosphatase for both LOS and CPS heptose biosynthesis...
  4. ncbi Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide
    Roberta Marchetti
    Dipartimento di Scienze Chimiche, Universita di Napoli Federico II, Italy
    Glycobiology 22:1387-98. 2012
    ..Additionally, the specific binding of fluorescent BC2L-A lectin on B. cenocepacia bacterial surface was demonstrated by microscopy...
  5. ncbi Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase
    Nicolas Desroy
    MUTABILIS SA, 102 Avenue Gaston Roussel, 93230 Romainville, France
    Bioorg Med Chem 17:1276-89. 2009
    Gram-negative bacteria lacking heptoses in their lipopolysaccharide (LPS) display attenuated virulence and increased sensitivity to human serum and to some antibiotics...
  6. ncbi Highly efficient synthesis of ketoheptoses
    Daniel Waschke
    University of Hamburg, Faculty of Science, Department of Chemistry, Martin Luther King Platz 6, 20146 Hamburg, Germany
    Org Lett 13:3628-31. 2011
    ..A reliable, facile, high overall yielding and diastereoselective synthesis of ketoheptoses was developed and applied for preparation of the two most diabetogenic ketoheptoses as well as in a modified version for the synthesis of kamusol...
  7. pmc The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose
    M A Valvano
    Department of Microbiology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Bacteriol 182:488-97. 2000
    ..We propose that Domain I is involved in the synthesis of D-glycero-D-manno-heptose 1-phosphate, whereas Domain II catalyzes the ADP transfer to form ADP-D-glycero-D-manno-heptose...
  8. ncbi The mechanism of the reaction catalyzed by ADP-beta-L-glycero-D-manno-heptose 6-epimerase
    Jay A Read
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Chem Soc 126:8878-9. 2004
    ..In addition, the deoxygenated analogues, 7' '-deoxy-ADP-l,d-Hep and 4' '-deoxy-ADP-l,d-Hep, were both found to serve as substrates for the enzyme, indicating that oxidation at either C-7' ' or C-4' ' is not required for catalysis...
  9. ncbi Efficient chemical synthesis of both anomers of ADP L-glycero- and D-glycero-D-manno-heptopyranose
    Alla Zamyatina
    Institute of Chemistry, University of Agricultural Sciences, Muthgasse 18, A 1190 Vienna, Austria
    Carbohydr Res 338:2571-89. 2003
    ..in the elucidation of biosynthetic pathways and glycosyl transfer reactions of nucleotide-activated bacterial heptoses. The alpha-anomers of the heptosyl phosphates were obtained in high yield and selectivity using the ..
  10. ncbi A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant
    C Michael Reynolds
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:21202-11. 2005
    ..Based on its sequence similarity to EptA(PmrC), we propose that the active site of EptB faces the periplasmic surface of the inner membrane...
  11. ncbi Synthesis of polyhydroxy amino acids based on D- and L-alanine from D-glycero-D-gulo-heptono-1,4-lactone
    Romina V Gómez
    CIHIDECAR CONICET, Departamento de Quimica Organica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Carbohydr Res 341:1498-504. 2006
    ..The diastereoisomer of 7 at C-2, 2-amino-2,3-dideoxy-D-gluco-heptonic acid (12) was also prepared from 3, by a route that involved 2,3-dideoxy-2-iodo derivative 8 as a key intermediate...
  12. ncbi Specific amino acids of the glycosyltransferase LpsA direct the addition of glucose or galactose to the terminal inner core heptose of Haemophilus influenzae lipopolysaccharide via alternative linkages
    Mary E Deadman
    Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Biol Chem 281:29455-67. 2006
    ....
  13. ncbi Structure of the Escherichia coli heptosyltransferase WaaC: binary complexes with ADP and ADP-2-deoxy-2-fluoro heptose
    Sylvestre Grizot
    Laboratoire de Cristallographie et RMN Biologiques, UMR 8015 CNRS, Universite Paris Descartes, Faculte de Pharmacie, 4, avenue de l Observatoire, F 75270 Paris Cedex 06, France
    J Mol Biol 363:383-94. 2006
    ..In addition, both binary complexes offer a close view of the donor subsite and, together with results from site-directed mutagenesis studies, provide evidence for a model of the catalytic mechanism...
  14. pmc Molecular analysis of the rfaD gene, for heptose synthesis, and the rfaF gene, for heptose transfer, in lipopolysaccharide synthesis in Salmonella typhimurium
    D M Sirisena
    Department of Biological Sciences, University of Calgary, Alberta, Canada
    J Bacteriol 176:2379-85. 1994
    ..coli K-12 is about 35%, much lower than the average of enteric bacteria; if this low G+C content is due to lateral transfer from a source of low G+C content, it must have occurred prior to evolutionary divergence of the two genera...
  15. ncbi Structural analysis of the capsular polysaccharide from Campylobacter jejuni RM1221
    Michel Gilbert
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, K1A 0R6, Canada
    Chembiochem 8:625-31. 2007
    ..We have also shown that the CPS biosynthesis genes of C. jejuni RM1221 are conserved in other C. jejuni strains of the Penner serotype HS:53, including serotype HS:53 reference strain RM3435...
  16. pmc Regulation of the Escherichia coli tryptophan operon by early reactions in the aromatic pathway
    W A Held
    J Bacteriol 101:202-8. 1970
    ..Owing to this competitive nature of tryptophan feedback inhibition of anthranilate synthetase by chorismic acid, the early pathway apparently serves to exert a regulatory influence on tryptophan biosynthesis...
  17. pmc Inhibition of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (trp) in Escherichia coli
    J Pittard
    J Bacteriol 97:1242-7. 1969
    ..The enzymic activity of DAHP synthetase (trp) in the presence of CO(2+) is sensitive to inhibition by tryptophan. Mutant strains of E. coli have been isolated in which DAHP synthetase (trp) is feedback-resistant...
  18. ncbi Interaction of recombinant surfactant protein D with lipopolysaccharide: conformation and orientation of bound protein by IRRAS and simulations
    Lin Wang
    Department of Chemistry, Newark College of Arts and Science, Rutgers University, Newark, New Jersey 07102, USA
    Biochemistry 47:8103-13. 2008
    ..The findings support the concept of specific binding between the CRD and heptoses in the core region of LPS...
  19. doi Retrospective detection of transaldolase deficiency in amniotic fluid: implications for prenatal diagnosis
    Mirjam M C Wamelink
    Prenat Diagn 28:460-2. 2008
  20. pmc Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance
    Sanjay Ram
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 75:4071-81. 2007
    ..This study provides mechanistic insights into how HepI LOS substitutions affect the serum resistance of N. gonorrhoeae...
  21. ncbi Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5
    Sven Muller-Loennies
    Research Center Borstel, Center for Medicine and Biosciences, Parkallee 22, D 23845 Borstel, Germany
    J Biol Chem 278:25618-27. 2003
    ..Affinities of E. coli R1, R3, and R4 oligosaccharides were 5-10-fold lower, and values from the E. coli J-5 mutant were 29-fold lower than the R2 core oligosaccharide. Thus, the outer core sugars had a positive effect on binding...
  22. ncbi Intestinal passive absorption of water-soluble compounds by sparrows: effect of molecular size and luminal nutrients
    J G Chediack
    Departamento de Bioquimica y Ciencias Biologicas, Universidad Nacional de San Luis, Casilla de Correos 226, 5700 San Luis, Argentina
    J Comp Physiol B 173:187-97. 2003
    ..These differences seem mainly attributable to differences in paracellular solvent flux and less to differences in effective paracellular pore size...
  23. pmc O-linked glycosylation ensures the normal conformation of the autotransporter adhesin involved in diffuse adherence
    Marie Eve Charbonneau
    Universite de Montreal, Faculte de Medecine Veterinaire, 3200 Sicotte, St Hyacinthe, Quebec J2S 7C6, Canada
    J Bacteriol 189:8880-9. 2007
    ..In this study, we identified several peptides of AIDA-I modified by the addition of heptoses by use of mass spectrometry and N-terminal sequencing of proteolytic fragments of AIDA-I...
  24. ncbi Aglycon specificity profiling of alpha-glucosidases using synthetic probes
    Wataru Hakamata
    Animal and Cellular Systems Laboratory, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 15:1489-92. 2005
    ..cerevisiae alpha-glucosidase among all alpha-glucosidases. Probe 4 was found to be a competitive inhibitor for S. cerevisiae alpha-glucosidase with Ki 0.13 mM...
  25. ncbi 7-O-galloyl-D-sedoheptulose ameliorates renal damage triggered by reactive oxygen species-sensitive pathway of inflammation and apoptosis
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, Toyama Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Pharm Pharmacol 64:1730-40. 2012
    ..This study was carried out to verify the preventive effects of 7-O-galloyl-d-sedoheptulose (GS), a phenolic compound isolated from Corni Fructus, underlying diabetic renal damage in type 2 diabetes...
  26. ncbi Carbohydrate metabolism of eggs of the whitefish, Coregonus spp. during embryogenesis and its relationship with egg quality
    Franz Lahnsteiner
    Department for Organismic Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria
    Comp Biochem Physiol B Biochem Mol Biol 142:46-55. 2005
    ..Coregonus spp. eggs contained hexoses, ketoses, 6-deoxyhexoses, heptoses and uronic acids with hexoses, ketoses, and 6-deoxysugars occurring free and in bound form...
  27. ncbi Novel lipopolysaccharide biosynthetic genes containing tetranucleotide repeats in Haemophilus influenzae, identification of a gene for adding O-acetyl groups
    Kate L Fox
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Mol Microbiol 58:207-16. 2005
    ..These results provide genetic and structural evidence that H. influenzae oafA is required for phase variable O-acetylation of LPS and functional evidence to support the role of O-acetylation of LPS in pathogenesis...
  28. ncbi Profiling structural elements of short-chain lipopolysaccharide of non-typeable Haemophilus influenzae
    Elke K H Schweda
    Clinical Research Centre, Karolinska Institutet and University College of South Stockholm, Novum, Huddinge, Sweden
    Innate Immun 14:199-211. 2008
    ..The present review focuses on LPS structures and mass spectrometric methods which enable us to profile these in complex mixtures...
  29. pmc Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis
    Pau Morey
    Laboratory Microbial Pathogenesis, Fundación Investigación Sanitaria Illes Balears FISIB, CSIC Govern de les Illes Balears, Bunyola, Spain
    Infect Immun 81:4100-11. 2013
    ..contributions of 2-keto-3-deoxyoctulosonic acid, the triheptose inner core, oligosaccharide extensions on heptoses I and III, phosphorylcholine, digalactose, and sialic acid to NTHi resistance to antimicrobial peptides (AMP), ..
  30. ncbi Expedient and versatile formation of novel amino-deoxy-ketoheptuloses
    Yevgeniy Leshch
    University of Hamburg, Faculty of Sciences, Department of Chemistry, Martin Luther King Platz 6, 20146 Hamburg, Germany
    Org Lett 15:4948-51. 2013
    ..A series of gluco and manno configured 1-/3-deoxy-1-/3-amino-ketohept-2-uloses could be obtained. ..
  31. ncbi Pasteurella multocida lipopolysaccharide: the long and the short of it
    Marina Harper
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Melbourne, VIC 3800, Australia
    Vet Microbiol 153:109-15. 2011
    ..Knowledge of the genetic basis for the LPS structures expressed by P. multocida will facilitate the development of rapid molecular methods for typing and diagnosis and will be essential for a rational approach to vaccine formulation...
  32. ncbi Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis
    Maxime Durka
    Chemistry Department, University of Namur, Rue de Bruxelles 61, 5000 Namur, Belgium
    Chemistry 17:11305-13. 2011
    L-Heptoses (L-glycero-D-manno-heptopyranoses) are constituents of the inner core of lipolysaccharide (LPS), a molecule playing key roles in the mortality of many infectious diseases as well as in the virulence of many human pathogens...
  33. ncbi gmhX, a novel gene required for the incorporation of L-glycero-D-manno-heptose into lipooligosaccharide in Neisseria meningitidis
    G C Shih
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Microbiology 147:2367-77. 2001
    ..GmhX is a novel enzyme required for the incorporation of L-glycero-D-manno-heptose into meningococcal LOS, and is a candidate for the 2-D-glycero-manno-heptose phosphatase of the heptose biosynthesis pathway...
  34. ncbi Effects of D-mannoheptose and D-glycero-D-gulo-heptose upon D-glucose metabolism and insulinotropic action in rat pancreatic islets and D-glucose phosphorylation by hexokinase isoenzymes: comparison with D-mannoheptulose
    P Courtois
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 6:171-5. 2000
    ..It is concluded, therefore, that neither D-mannoheptose nor D-glycero-D-guloheptose can be considered as suitable substitutes of D-mannoheptulose...
  35. ncbi Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
    Simone Baltrusch
    Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
    Biochem Pharmacol 83:1300-6. 2012
    ..Thus, as a result of the additive effect of both activators on glucokinase activity, the largest increase of glucose-induced insulin secretion was observed in the combined presence of PFK-2/FBPase-2 and LY2121260...
  36. ncbi 7-O-galloyl-D-sedoheptulose attenuates oxidative stress-induced diabetic injury via decreasing expression of nuclear factor-κB- and apoptosis-related protein in the liver
    Jeong Sook Noh
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 35:950-6. 2012
    ..Taking these into consideration, our findings support the therapeutic evidence for GS ameliorating the development of diabetic complications via regulating oxidative stress, inflammation, and apoptosis...
  37. pmc Complete 6-deoxy-D-altro-heptose biosynthesis pathway from Campylobacter jejuni: more complex than anticipated
    Matthew McCallum
    Department of Microbiology and Immunology, Infectious Diseases Research Group, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 287:29776-88. 2012
    ..jejuni strains and other pathogens. It provides new molecular tools for the synthesis of carbohydrate antigens useful for vaccination and for the screening of enzymatic inhibitors that may have antibacterial effects...
  38. ncbi Involvement of lipooligosaccharide heptose residues of Haemophilus parasuis SC096 strain in serum resistance, adhesion and invasion
    Chenggang Xu
    Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, People s Republic of China
    Vet J 195:200-4. 2013
    ..This study provides insight into the contribution of the inner core oligosaccharide, especially heptose I and heptose II residues, to the virulence-associated properties of H. parasuis...
  39. ncbi Synthesis and stereoselective glycosylation of D- and L-glycero-beta-D-manno-heptopyranoses
    David Crich
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    Org Lett 7:1395-8. 2005
    ..The method relies on the presence of a 4,6-O-benzylidene acetal to effect stereocontrol at the anomeric center; the configuration at C6 (L- or D-glycero) is of minimal importance...
  40. ncbi Separation of 6-deoxy-heptan [correction of 6-deoxy-heptane] from a smooth-type lipopolysaccharide preparation of Burkholderia pseudomallei
    Y Isshiki
    Department of Bacteriology, The Kitasato Institute, Tokyo, Japan
    FEMS Microbiol Lett 199:21-5. 2001
    ..The 6-deoxy-heptan [corrected] showed no macrophage activation, indicating that this polysaccharide was not the LPS, but one of the capsular polysaccharides of B. pseudomallei...
  41. pmc Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression
    Rebecca J Malott
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 110:10234-9. 2013
    ..Our study thereby shows that heptose is a microbial-specific product that is sensed as an innate immune agonist and unveils the molecular link between N. gonorrhoeae and HIV-1...
  42. pmc Genetic and structural characterization of L11 lipooligosaccharide from Neisseria meningitidis serogroup A strains
    Noëlle Mistretta
    Sanofi Pasteur, 1541 Avenue Marcel Merieux, 69280 Marcy l Etoile, France
    J Biol Chem 285:19874-83. 2010
    ..oligosaccharides were consistent with an oligosaccharide composed of two hexoses, one N-acetyl-hexosamine, two heptoses, and one KDO, as proposed previously...
  43. pmc Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli
    B J Wallace
    J Bacteriol 97:1234-41. 1969
    ..The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR...
  44. pmc Effects of lipopolysaccharide biosynthesis mutations on K1 polysaccharide association with the Escherichia coli cell surface
    Natalia Jimenez
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Barcelona, Barcelona, Spain
    J Bacteriol 194:3356-67. 2012
    ..These results suggest that the K1 polysaccharide remains cell associated by ionically interacting with the phosphate-negative charges of the core LPS...
  45. ncbi Structure of the O-polysaccharide of Photorhabdus luminescens subsp. laumondii containing D-glycero-D-manno-heptose and 3,6-dideoxy-3-formamido-D-glucose
    Anna N Kondakova
    N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Carbohydr Res 351:134-7. 2012
    ..The following structure of the pentasaccharide repeating unit of the O-polysaccharide was established:..
  46. ncbi The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site
    Nicholas J Harmer
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK
    J Mol Biol 400:379-92. 2010
    b>Heptoses are found in the surface polysaccharides of most bacteria, contributing to structures that are essential for virulence and antibiotic resistance...
  47. ncbi Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block
    Takafumi Ohara
    Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14776 Potsdam, Germany
    Chem Commun (Camb) 46:4106-8. 2010
    ..A short and enantioselective de novo synthesis of an L-glycero-D-manno-heptose building block for the total synthesis of a Yersinia pestis cell wall polysaccharide is described...
  48. ncbi Elevated concentrations of sedoheptulose in bloodspots of patients with cystinosis caused by the 57-kb deletion: implications for diagnostics and neonatal screening
    M M C Wamelink
    VU University Medical Center, Department of Clinical Chemistry, Metabolic Unit, Amsterdam, The Netherlands
    Mol Genet Metab 102:339-42. 2011
    ..We feel that the presented method enables fast (pre)-symptomatic detection of cystinosis patients homozygous for the 57-kb deletion, allowing early treatment...
  49. ncbi Iodomethyl group as a hydroxymethyl synthetic equivalent: application to the syntheses of D-manno-hept-2-ulose and l-fructose derivatives
    Bernard Bessières
    Universite Joseph Fourier, UMR CNRS 5616, Chimie Recherche LEDSS, BP 53, 38041 Grenoble Cedex 9, France
    J Org Chem 68:4100-3. 2003
    ....
  50. pmc Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency
    Udo F H Engelke
    Radboud University Nijmegen Medical Centre, Department of Laboratory Medicine, Laboratory of Genetic Endocrine and Metabolic Diseases, Nijmegen, The Netherlands
    Biochim Biophys Acta 1802:1028-35. 2010
    ..Sedoheptulose, arabitol, ribitol, and erythritol have been identified as key diagnostic metabolites in TALDO deficiency...
  51. ncbi Heptanosides from galactose-derived oxepenes via stereoselective addition reactions
    Rhys Batchelor
    Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
    J Org Chem 74:7627-32. 2009
    ..The 3,4-anhydroheptanose used in this study is obtained from the ring-expansion of a cyclopropanated galactal and thus demonstrates the synthetic utility of heptanose synthesis via cyclopropanated carbohydrates...
  52. ncbi Structural analysis of lipopolysaccharides from Haemophilus influenzae serotype f. Structural diversity observed in three strains
    Håkan H Yildirim
    Clinical Research Centre, Karolinska Institutet, Sweden
    Eur J Biochem 270:3153-67. 2003
    ..A with variable length of OS chains linked to each of the heptoses. The terminal heptose (HepIII) in RM6255 is substituted at the O-3 position by a beta-d-Glcp residue whereas ..
  53. pmc Enhanced biofilm formation by Escherichia coli LPS mutants defective in Hep biosynthesis
    Ryoma Nakao
    Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Umea University, Umea, Sweden
    PLoS ONE 7:e51241. 2012
    ..We suggest that the implication of these results should be considered in the context of biofilm formation on abiotic surfaces, which is frequently associated with nosocominal infections such as the catheter-associated infections...
  54. ncbi Lipopolysaccharide core structures and their correlation with genetic groupings of Shigella strains. A novel core variant in Shigella boydii type 16
    Yuriy A Knirel
    ND Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii Prospekt 47, 119991 Moscow, Russia
    Glycobiology 21:1362-72. 2011
    ..This finding supports a notion on the existing Shigella species as invalid taxa and a suggestion of multiple independent origins of Shigella from E. coli clones...
  55. pmc Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region
    Gracjana Klein
    Leibniz Center for Medicine and Biosciences, Parkallee 22, 23845 Borstel, Germany
    J Biol Chem 288:8111-27. 2013
    ..This P-EtN modification is essential for resistance to a variety of factors, which destabilize the outer membrane like the addition of SDS or challenge to sublethal concentrations of Zn(2+)...
  56. ncbi Beneficial effect of 7-O-galloyl-D-sedoheptulose on oxidative stress and hepatic and renal changes in type 2 diabetic db/db mice
    Chan Hum Park
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 640:233-42. 2010
    ..In conclusion, GS could have hepato- and reno-protective effects against abnormal lipid metabolism and the reactive oxygen species-related formation of advanced glycation endproducts with inflammation in type 2 diabetes...
  57. ncbi The biosynthesis and biological role of 6-deoxyheptose in the lipopolysaccharide O-antigen of Yersinia pseudotuberculosis
    Nathan Ho
    Department of Microbiology and Immunology, Infectious Diseases Research Group, University of Western Ontario, London, Ontario, Canada
    Mol Microbiol 68:424-47. 2008
    ..Although both mutants colonized the mouse ceacum as well as the wild type, the dmhB mutant was impaired for colonization of the liver, suggesting that DmhB represents a potential therapeutic target...
  58. pmc The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism
    Thomas Kowatz
    Biomolecular Sciences Research Complex, The University of St Andrews, Fife KY16 9RH, United Kingdom
    Protein Sci 19:1337-43. 2010
    ..The complex identifies the key residues and allows mechanistic insight into this novel enzyme...
  59. doi Synthesis and quantitative evaluation of Glycero-D-manno-heptose binding to concanavalin A by fluorous-tag assistance
    Firoz A Jaipuri
    Department of Chemistry, 2606 Gilman Hall, Iowa State University, USA
    Angew Chem Int Ed Engl 47:1707-10. 2008
  60. ncbi Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene
    Mirjam M C Wamelink
    Department of Clinical Chemistry, Metabolic Unit, VU University Medical Center, Amsterdam, The Netherlands
    Hum Mutat 29:532-6. 2008
    ....
  61. ncbi A convenient synthesis of GDP D-glycero-alpha-D-manno-heptopyranose
    Andrea Graziani
    Institute of Chemistry, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    Carbohydr Res 339:147-51. 2004
    ....
  62. ncbi Phosphoethanolamine is located at the 6-position and not at the 7-position of the distal heptose residue in the lipopolysaccharide from Neisseria meningitidis
    Frank St Michael
    Institute for Biological Sciences, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Glycobiology 19:1436-45. 2009
    ..We discuss the implications of these findings with respect to the immunotyping scheme for the meningococci and in the context of LPS-based vaccine development...
  63. ncbi A reinvestigation of the lipopolysaccharide structure of Helicobacter pylori strain Sydney (SS1)
    Eleonora Altman
    Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
    FEBS J 278:3484-93. 2011
    ..pylori SS1 LPS was found to contain a novel LacNAc unit carrying a phosphoethanolamine substituent at the O-6 position of β-GlcNAc residues...
  64. ncbi NMR spectral mapping of Lipid A molecular patterns affected by interaction with the innate immune receptor CD14
    Seth Albright
    Biochemistry, Cellular and Molecular Biology Department, University of Tennessee, Knoxville, TN 37996 0840, USA
    Biochem Biophys Res Commun 378:721-6. 2009
    ..Additionally, we have detected for the first time, presence of differential dynamic behavior for the affected resonances, suggesting a likely role for dynamics in the mechanism of Lipid A pattern recognition by sCD14...
  65. pmc Crystal and molecular structure of methyl L-glycero-α-D-manno-heptopyranoside, and synthesis of 1→7 linked L-glycero-D-manno-heptobiose and its methyl α-glycoside
    Daniel Artner
    Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria
    Carbohydr Res 346:1739-46. 2011
    ....
  66. ncbi Towards the synthesis of new dideoxy delta-dicarbonyl heptoses
    Venerando Pistarà
    Universita di Catania, Dipartimento di Scienze Chimiche, I 95125 Catania, Italy
    Carbohydr Res 345:1482-5. 2010
    ..Moreover this is, to our best knowledge, the first reported example of an elongation to a higher sugar starting from a spirocyclopropanated saccharide...
  67. ncbi Structure of the lipopolysaccharide core of Vibrio vulnificus type strain 27562
    Evguenii Vinogradov
    Institute for Biological Sciences, National Research Council, Ont, Canada
    Carbohydr Res 344:484-90. 2009
    ..NMR spectroscopic data corresponded to the presence of one Kdo residue, one beta-glucopyranose, three heptoses, one glyceric acid, one acetate, three PEtN, and one 5,7-diacylamido-3,5,7,9-tetradeoxynonulosonic acid residue (..
  68. pmc Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B
    Ximena Ortega
    Infectious Diseases Research Group, Siebens Drake Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 284:21738-51. 2009
    ..The core OS structure consists of three heptoses in the inner core region, 3-deoxy-d-manno-octulosonic acid, d-glycero-d-talo-octulosonic acid, and 4-amino-4-..
  69. ncbi Elucidating the formation of 6-deoxyheptose: biochemical characterization of the GDP-D-glycero-d-manno-heptose C6 dehydratase, DmhA, and its associated C4 reductase, DmhB
    Frank D Butty
    Department of Microbiology and Immunology, Infectious Diseases Research Group, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Biochemistry 48:7764-75. 2009
    ..Also, it allows the screening for inhibitors, the elucidation of substrate specificity determinants, and the synthesis of carbohydrate antigens of therapeutic relevance...
  70. ncbi Genes required for the synthesis of heptose-containing oligosaccharide outer core extensions in Haemophilus influenzae lipopolysaccharide
    Derek W Hood
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Microbiology 156:3421-31. 2010
    ..Our studies confirm that losB1 and losB2 usually encode dd-heptosyl- and ld-heptosyl transferases, respectively, and that losA1 and losA2 encode glycosyltransferases that play a role in OS extensions of NTHi LPS...
  71. ncbi Neoadjuvant chemotherapy with a combination of docetaxel, cisplatin, fluorouracil, and leucovorin in nonresectable advanced gastric cancer: a short communication
    Yanlei Ma
    Department of Surgery, The Sixth People s Hospital Affiliated to Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, 200233, People s Republic of China
    Med Oncol 27:1089-95. 2010
    ..6%. The most common toxicities were bone marrow suppression, nausea, vomiting, alopecia, and heptoses. The toxicities were recoverable after symptomatic treatment...
  72. ncbi Tandem RCM-isomerization approach to glycals of desoxyheptoses from a common precursor
    Bernd Schmidt
    Institut fuer Chemie, Organische Chemie II, Universitaet Potsdam, Karl Liebknecht Strasse 24 25, D 14476 Golm, Germany
    Org Lett 10:105-8. 2008
    ..The products of the tandem RCM-isomerization sequence are glycals of 3-deoxyheptoses of varying ring size...
  73. ncbi The rfaC gene of Salmonella typhimurium. Cloning, sequencing, and enzymatic function in heptose transfer to lipopolysaccharide
    D M Sirisena
    Department of Biological Sciences, University of Calgary, Alberta, Canada
    J Biol Chem 267:18874-84. 1992
    ....
  74. ncbi Lipopolysaccharide core phosphates are required for viability and intrinsic drug resistance in Pseudomonas aeruginosa
    A G Walsh
    Department of Microbiology, University of Guelph, Guelph, ON N1G 2W1, Canada
    Mol Microbiol 35:718-27. 2000
    ..The inner core phosphates of P. aeruginosa appear to be playing a key role in the intrinsic drug resistance of this bacterium...
  75. ncbi Distribution of pyranose and furanose forms of 6-deoxyheptoses in water solution
    A S Shashkov
    N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
    Carbohydr Res 330:289-94. 2001
    ..Water solution of 6-deoxyheptoses contains all possible furanose and pyranose forms (except 6-deoxy-gluco-heptose for which only pyranose was found), although pyranose is dominant...
  76. ncbi Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose
    B Kneidinger
    Zentrum fur Ultrastrukturforschung und Ludwig Boltzmann Institut fur Molekulare Nanotechnologie, Universitat fur Bodenkultur Wien, Gregor Mendel Strasse 33, A 1180 Wien, Austria
    J Biol Chem 276:20935-44. 2001
    ..This is the first report of the biosynthesis of GDP-d-glycero-alpha-d-manno-heptose in Gram-positive organisms. In addition, we propose a pathway for biosynthesis of the nucleotide-activated form of l-glycero-d-manno-heptose...
  77. ncbi Structure of a D-glycero -D-manno-heptan from the lipopolysaccharide of Helicobacter pylori
    S N Senchenkova
    Karolinska Institute, Clinical Research Centre, Huddinge University Hospital, Novum, Sweden
    Carbohydr Res 331:219-24. 2001
    ..1H NMR spectroscopy performed on small amounts of the intact LPS revealed the presence of the same polysaccharide in LPS of H. pylori strains D2 and D5, but not strain D10...
  78. ncbi Characterization of the physiological substrate for lipopolysaccharide heptosyltransferases I and II
    S Gronow
    Medical and Biochemical Microbiology, Research Center Borstel, Germany
    J Endotoxin Res 7:263-70. 2001
    ..This compound represented the sole constituent of the bacterial extract that was accepted as a sugar donor by heptosyltransferases I and II in vitro...
  79. ncbi Complete 1H and 13C spectral assignment of floridoside
    Christelle Simon-Colin
    Laboratoire d Ecophysiologie et de Biotechnonologie des Halophytes et des Algues Marines, Institut Universitaire Europeen de la Mer, Universite de Bretagne Occidentale, Technopole Brest Iroise, F 29280, Plouzane, France
    Carbohydr Res 337:279-80. 2002
    ....
  80. pmc Functional substitution of the TibC protein of enterotoxigenic Escherichia coli strains for the autotransporter adhesin heptosyltransferase of the AIDA system
    Corinna Moormann
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Infect Immun 70:2264-70. 2002
    ..A potential consensus sequence for the modification site is suggested...
  81. ncbi Indonesian medicinal plants. XXIV. Stereochemical structure of perseitol x K+ complex isolated from the leaves of Scurrula fusca (Loranthaceae)
    Takashi Ishizu
    Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan
    Chem Pharm Bull (Tokyo) 50:489-92. 2002
    ..Furthermore, it has been found that the complex exhibits a potent inhibitory effect on [3H]-leucine incorporation for protein synthesis in Ehrlich ascites tumor cells in mice...
  82. ncbi Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides
    C P Schultz
    Robert Koch Institut, D 13353 Berlin, Nordufer 20, Germany
    J Biol Chem 273:15661-6. 1998
    ..Rare for outer membrane lipids, OML contains no significant amount of 3-deoxy-D-manno-octulosonic acids, heptoses, and beta-hydroxy fatty acids...
  83. ncbi Analysis of the icsBA locus required for biosynthesis of the inner core region from Neisseria meningitidis lipopolysaccharide
    P van der Ley
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Microbiol Lett 146:247-53. 1997
    ..Only then is completion of the lacto-N-neotetraose structure possible through the action of the IgtA-E genes...
  84. ncbi The O polysaccharide chain of the lipopolysaccharide from Vibrio cholerae O76 is a homopolymer of N-[(S)-(+)-2-hydroxypropionyl]-alpha-L-perosamine
    S Kondo
    Department of Microbiology, School of Pharmaceutical Sciences, Josai University Sakado, Saitama, Japan
    Microbiology 142:2879-85. 1996
    ..cholerae O1, is related substantially and exclusively to their alpha(1-->2)-linked homopolymers of N-acylated D-perosamine, and not to such homopolymers of N-acylated L-perosamine...
  85. pmc Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity and decreases succinyl-CoA content in liver
    P A Quant
    Department of Biochemistry, University of Cambridge, U K
    Biochem J 262:159-64. 1989
    ..They support the hypothesis that the formation of ketone bodies from acetyl-CoA may be regulated by the extent of succinylation of mitochondrial HMG-CoA synthase...
  86. ncbi Endotoxin shock and tumour necrosis factor release in mannoheptulose-treated mice
    Y M Choy
    Department of Biochemistry, Chinese University of Hong Kong, Shatin
    Cancer Lett 37:33-9. 1987
    ..Mannoheptulose was observed to reverse the hypoglycaemic effect of endotoxin, possibly through inhibition of insulin secretion. The therapeutic significance of these observations is discussed...
  87. pmc New cysE-pyrE-linked rfa mutation in Escherichia coli K-12 that results in a heptoseless lipopolysaccharide
    W G Coleman
    J Bacteriol 161:1209-14. 1985
    ....
  88. pmc Repression of aromatic amino acid biosynthesis in Escherichia coli K-12
    K D Brown
    J Bacteriol 108:386-99. 1971
    ..DAHP synthetase (trp) and tryptophan synthetase were repressed by tryptophan and have previously been shown to be under the control of the trpR regulatory gene. These enzymes also were unaffected by tyrR...
  89. pmc Regulation of 3-deoxy-D-arabino-heptulosonic 7-phosphate acid synthetase activity in relation to the synthesis of the aromatic vitamins in Escherichia coli K-12
    B J Wallace
    J Bacteriol 99:707-12. 1969
    ..Under repressed conditions both DAHP synthetase (phe) and (trp), but not DAHP synthetase (tyr), were shown to contribute to vitamin production...
  90. pmc Genetics of lipopolysaccharide biosynthesis in enteric bacteria
    C A Schnaitman
    Department of Microbiology, Arizona State University, Tempe 85287 2701
    Microbiol Rev 57:655-82. 1993
    ....
  91. pmc Microheterogeneity of Neisseria lipooligosaccharide: analysis of a UDP-glucose 4-epimerase mutant of Neisseria meningitidis NMB
    F K Lee
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    Infect Immun 63:2508-15. 1995
    ..g., Hexn-->(HexNAc)-->Hep2PEA-->KDO2 (n = 2, 3, or 4), emanating from one or both heptoses were also identified. Since this mutant cannot synthesize UDP-Gal, these structures must repetitive glucoses...
  92. ncbi Heptose-deficient mutants of Escherichia coli K12 deficient in up to three major outer membrane proteins
    W van Alphen
    Mol Gen Genet 147:263-9. 1976
    ..Heptose-deficient strains have an increased amount of 2-keto-3-deoxyoctonate...
  93. pmc Relationship of Yersinia pseudotuberculosis O antigens IA, IIA, and IVB: the IIA gene cluster was derived from that of IVB
    Elvia Pacinelli
    Department of Microbiology, The University of Sydney, Sydney, New South Wales 2006, Australia
    Infect Immun 70:3271-6. 2002
    ..All three O antigens contain 6-deoxy-D-mannoheptose, and we identified six genes for the biosynthetic pathway for the precursor of this sugar, GDP-6-deoxy-D-mannoheptose...
  94. ncbi Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides
    Miguel A Valvano
    Department of Microbiology and Immunology and Medicine, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Microbiology 148:1979-89. 2002
  95. ncbi Monosaccharide esters: new tools in biomedicine
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Acta Clin Belg 57:49-52. 2002
    ..This topic was first reviewed in 1998 (2). The major aim of the present report is to briefly evoke the background and present knowledge in this field...
  96. pmc Triple mutants uncover three new genes required for social motility in Myxococcus xanthus
    Philip Youderian
    Department of Biology, Texas A and M University, College Station, Texas 83843 3052, USA
    Genetics 177:557-66. 2007
    ..xanthus is quite large...
  97. ncbi Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine
    M M Wamelink
    Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    J Inherit Metab Dis 30:735-42. 2007
    ..Our findings reveal novel urinary biomarkers for identification of transaldolase deficiency...
  98. ncbi Phosphoheptose isomerase, first enzyme in the biosynthesis of aldoheptose in Salmonella typhimurium
    L Eidels
    J Biol Chem 249:5642-8. 1974
  99. pmc Stereocontrolled synthesis of the D- and L-glycero-beta-D-manno-heptopyranosides and their 6-deoxy analogues. Synthesis of methyl alpha-l-rhamno-pyranosyl-(1-->3)-D-glycero-beta-D-manno-heptopyranosyl- (1-->3)-6-deoxy-glycero-beta-D-manno-heptopyran
    David Crich
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    J Am Chem Soc 128:8078-86. 2006
    ....
  100. ncbi A short synthesis of D-glycero-D-manno-heptose 7-phosphate
    Hacer Guzlek
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    Carbohydr Res 340:2808-11. 2005
    D-glycero-D-manno-Heptopyranose 7-phosphate-an intermediate in the biosynthesis of nucleotide-activated heptoses-has been prepared in good overall yield from benzyl 5,6-dideoxy-2,3-O-isopropylidene-alpha-D-lyxo-(Z)-hept-5-enofuranoside by ..
  101. ncbi Recognition of septanose carbohydrates by concanavalin A
    Steve Castro
    Department of Chemistry, University of Connecticut, 55 North Eagleville Road U 3060, Storrs, CT 06269, USA
    Org Biomol Chem 3:3869-72. 2005
    ..The ability of the jack bean lectin concanavalin A (ConA) to bind seven membered ring (septanose) monosaccharides has been investigated by isothermal titration calorimetry (ITC) and saturation transfer difference (STD) NMR spectroscopy...

Research Grants1

  1. Glycosylation of Campylobacter flagella
    Patricia Guerry; Fiscal Year: 2007
    ..The biological role of flagella glycosylation will be studied by examining a series of mutants in in vitro and in vivo assays of virulence. ..