glycosylated hemoglobin a

Summary

Summary: Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.

Top Publications

  1. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003
  2. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
  3. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
  4. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
  5. ncbi 10-year follow-up of intensive glucose control in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    N Engl J Med 359:1577-89. 2008
  6. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
  7. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
  8. ncbi Biology of incretins: GLP-1 and GIP
    Laurie L Baggio
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 132:2131-57. 2007
  9. ncbi Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    N Engl J Med 356:2457-71. 2007
  10. ncbi Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials
    N G Boulé
    Clinical Epidemiology Unit, Ottawa Health Research Institute, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 286:1218-27. 2001

Detail Information

Publications294 found, 100 shown here

  1. ncbi Follow-up report on the diagnosis of diabetes mellitus
    Saul Genuth
    Diabetes Care 26:3160-7. 2003
  2. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  3. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  4. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  5. ncbi 10-year follow-up of intensive glucose control in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    N Engl J Med 359:1577-89. 2008
    ..We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes...
  6. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
    ..Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation of oxidative stress...
  7. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    ..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
  8. ncbi Biology of incretins: GLP-1 and GIP
    Laurie L Baggio
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 132:2131-57. 2007
    ..Recently approved therapeutic agents based on potentiation of incretin action provide new physiologically based approaches for the treatment of type 2 diabetes...
  9. ncbi Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    N Engl J Med 356:2457-71. 2007
    ..Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but its effect on cardiovascular morbidity and mortality has not been determined...
  10. ncbi Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials
    N G Boulé
    Clinical Epidemiology Unit, Ottawa Health Research Institute, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 286:1218-27. 2001
    ..However, clinical trials on the effects of exercise in patients with type 2 diabetes have had small sample sizes and conflicting results...
  11. pmc Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    David M Nathan
    N Engl J Med 353:2643-53. 2005
    ..We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease...
  12. ncbi Association of health literacy with diabetes outcomes
    Dean Schillinger
    University of California, San Francisco, Primary Care Research Center, Department of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    JAMA 288:475-82. 2002
    ..Little is known about the extent to which health literacy affects clinical health outcomes...
  13. ncbi Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  14. ncbi Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)
    Louis Monnier
    Department of Metabolism, Lapeyronie Hospital, Montpellier, France
    Diabetes Care 26:881-5. 2003
    ..To test the effect of overall glycemic control itself, we analyzed the diurnal glycemic profiles of type 2 diabetic patients investigated at different levels of HbA(1c)...
  15. ncbi Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Lancet 374:39-47. 2009
    ..We compared the efficacy and safety of liraglutide, a human GLP-1 analogue, with exenatide, an exendin-based GLP-1 receptor agonist...
  16. ncbi Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    V Fonseca
    Endocrinology Department, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Diabetologia 50:1148-55. 2007
    ..This study assessed the efficacy and tolerability of vildagliptin added to insulin therapy in patients with type 2 diabetes...
  17. ncbi Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    L Blonde
    Ochsner Clinic Foundation, New Orleans, LA, USA
    Diabetes Obes Metab 8:436-47. 2006
    ..This analysis examined the effects of exenatide on glycaemic control and weight over an 82-week period in patients with DM2 unable to achieve adequate glycaemic control with sulphonylurea (SU) and/or metformin (MET)...
  18. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  19. ncbi Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    R C Turner
    Radcliffe Infirmary, Oxford, England
    JAMA 281:2005-12. 1999
    ..8 mmol/L (140 mg/dL) or glycosylated hemoglobin A1c (HbA1c) below 7% is unknown...
  20. ncbi HbA(1c) as a screening tool for detection of Type 2 diabetes: a systematic review
    C M Bennett
    Department of Public Health, School of Population Health, The University of Melbourne, Australia
    Diabet Med 24:333-43. 2007
    ..To assess the validity of glycated haemoglobin A(1c) (HbA(1c)) as a screening tool for early detection of Type 2 diabetes...
  21. ncbi Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet
    Iris Shai
    S Daniel Abraham Center for Health and Nutrition, Ben Gurion University of the Negev, Beer Sheva, Israel
    N Engl J Med 359:229-41. 2008
    ..Trials comparing the effectiveness and safety of weight-loss diets are frequently limited by short follow-up times and high dropout rates...
  22. pmc Long-term effect of diabetes and its treatment on cognitive function
    Alan M Jacobson
    N Engl J Med 356:1842-52. 2007
    ..Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia...
  23. ncbi Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
    Daniel J Drucker
    Department of Medicine, Banting and Best Diabetes Centre, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Lancet 372:1240-50. 2008
    ..We compared the efficacy of a once-weekly formulation of exenatide to that of a twice daily dose...
  24. ncbi The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, 34295 Montpellier Cedex 5, France
    Diabetes Care 30:263-9. 2007
    ..The aim of the study was to determine whether the loss of fasting and postprandial glycemic control occurs in parallel or sequentially in the evolution of type 2 diabetes...
  25. ncbi Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    Kausik K Ray
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Lancet 373:1765-72. 2009
    ..We undertook a meta-analysis of randomised controlled trials to determine whether intensive treatment is beneficial...
  26. ncbi IFCC reference system for measurement of hemoglobin A1c in human blood and the national standardization schemes in the United States, Japan, and Sweden: a method-comparison study
    Wieland Hoelzel
    Roche Diagnostics GmbH, Penzberg, Germany
    Clin Chem 50:166-74. 2004
    ..The aim of the present study was to determine the relationships between the IFCC Reference Method (RM) and the DCMs...
  27. ncbi Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    A A Young
    Amylin Pharmaceuticals, San Diego, California 92121, USA
    Diabetes 48:1026-34. 1999
    ..0 microg/kg+/-0.15 log and 2.4 microg/kg+/-0.41 log, respectively. In conclusion, acute and chronic administration of exendin-4 has demonstrated an antidiabetic effect in several animal models of type 2 diabetes...
  28. pmc Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial
    M J Davies
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW
    BMJ 336:491-5. 2008
    ..To evaluate the effectiveness of a structured group education programme on biomedical, psychosocial, and lifestyle measures in people with newly diagnosed type 2 diabetes...
  29. ncbi Vascular risk factors and diabetic neuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    N Engl J Med 352:341-50. 2005
    ..We studied risk factors for the development of distal symmetric neuropathy in 1172 patients with type 1 diabetes mellitus from 31 centers participating in the European Diabetes (EURODIAB) Prospective Complications Study...
  30. ncbi The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    Bogdan Balas
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Drive, MC 7886, San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 92:1249-55. 2007
    ..However, little is known about the mechanism(s) by which vildagliptin promotes reduction in plasma glucose concentration...
  31. ncbi Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy
    Robert M Cohen
    Division of Endocrinology, Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0547, USA
    Diabetes Care 26:163-7. 2003
    ..We termed this the glycosylation gap (GG) and sought to determine its relationship to diabetic nephropathy...
  32. ncbi Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients
    Erkan Coban
    Department of Internal Medicine, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Acta Haematol 112:126-8. 2004
    ..In patients with IDA, HbA1c decreased significantly after iron treatment from a mean of 7.4% +/- 0.8 to 6.2% +/- 0.6 (p < 0.001). Iron deficiency must be corrected before any diagnostic or therapeutic decision is made based on HbA1c...
  33. pmc A1C variability and the risk of microvascular complications in type 1 diabetes: data from the Diabetes Control and Complications Trial
    Eric S Kilpatrick
    Department of Clinical Biochemistry, Hull Royal Infirmary, Hull, UK
    Diabetes Care 31:2198-202. 2008
    ..In this study, we analyzed data from the Diabetes Control and Complications Trial (DCCT) to assess the effect of A1C variability on the risk of retinopathy and nephropathy in patients with type 1 diabetes...
  34. ncbi Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study
    Elizabeth Selvin
    Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
    Arch Intern Med 165:1910-6. 2005
    ..Chronic hyperglycemia has been hypothesized to contribute to coronary heart disease (CHD), but the extent to which hemoglobin A(1c) (HbA(1c)) level, a marker of long-term glycemic control, is independently related to CHD risk is uncertain...
  35. pmc Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004
    LYDIE N PANI
    Department of Medicine, Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:1991-6. 2008
    ..We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts...
  36. pmc Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study
    Kyoko Kogawa Sato
    Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 32:644-6. 2009
    ..We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes...
  37. pmc Disparities in HbA1c levels between African-American and non-Hispanic white adults with diabetes: a meta-analysis
    Julienne K Kirk
    Family and Community Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1084, USA
    Diabetes Care 29:2130-6. 2006
    ..Data sources included PubMed, Web of Science, the Cumulative Index to Nursing and Allied Health, the Cochrane Library, the Combined Health Information Database, and the Education Resources Information Center...
  38. ncbi The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial
    John M Lachin
    The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
    Diabetes 56:1913-21. 2007
    ..The HGI should not be used to estimate risk of complications or to guide therapy...
  39. pmc Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS)
    Juliana C N Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Diabetes Care 32:227-33. 2009
    ..The International Diabetes Mellitus Practice Study is a 5-year survey documenting changes in diabetes treatment practice in developing regions...
  40. ncbi Kidney function after islet transplant alone in type 1 diabetes: impact of immunosuppressive therapy on progression of diabetic nephropathy
    Paola Maffi
    Department of Medicine, Transplant Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Diabetes Care 30:1150-5. 2007
    ..The aim of our study was to assess the impact of the Edmonton immunosuppressive protocol (tacrolimus-sirolimus association) on kidney function...
  41. ncbi Impact of diabetes on physical function in older people
    Alan J Sinclair
    University of Bedfordshire, Luton, UK
    Diabetes Care 31:233-5. 2008
    ..To explore the nature of functional impairment in older people with diabetes...
  42. ncbi Guidelines for improving the care of the older person with diabetes mellitus
    Arlene F Brown
    J Am Geriatr Soc 51:S265-80. 2003
  43. ncbi Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Napoli, Italy
    J Clin Endocrinol Metab 93:1345-50. 2008
    ..Two-hour postprandial hyperglycemia is related to chronic complications of diabetes and is currently used in the international guidelines to drive the therapy...
  44. ncbi Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    Barry J Goldstein
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Diabetes Care 30:1979-87. 2007
    ..To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise...
  45. pmc Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
    Catherine L Martin
    Diabetes Control and Complications Trial DCCT Epidemiology of Diabetes Intervention and Complications EDIC Research Group, Bethesda, MD 20892, USA
    Diabetes Care 29:340-4. 2006
    ..To evaluate the impact of prior intensive diabetes therapy on neuropathy among former Diabetes Control and Complications Trial (DCCT) participants...
  46. ncbi Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
    Elizabeth Selvin
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann Intern Med 141:421-31. 2004
    ..In persons with diabetes, chronic hyperglycemia (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated hemoglobin to macrovascular disease is less clear...
  47. ncbi The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    H C Gerstein
    McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada
    Diabetologia 48:1749-55. 2005
    ....
  48. ncbi Effects of quality improvement strategies for type 2 diabetes on glycemic control: a meta-regression analysis
    Kaveh G Shojania
    Ottawa Health Research Institute and Department of Medicine, University of Ottawa, Ottawa, Ontario
    JAMA 296:427-40. 2006
    ..There have been numerous reports of interventions designed to improve the care of patients with diabetes, but the effectiveness of such interventions is unclear...
  49. ncbi Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial
    Reinhard G Bretzel
    Medizinische Klinik und Poliklinik III, Justus Liebig Universitat, Giessen, Germany
    Lancet 371:1073-84. 2008
    ....
  50. ncbi Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, United Kingdom
    N Engl J Med 357:1716-30. 2007
    ..Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited...
  51. ncbi Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 48:298-304. 2006
    ..This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy...
  52. ncbi Association of vitreous inflammatory factors with diabetic macular edema
    Hideharu Funatsu
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Yachiyo, Japan
    Ophthalmology 116:73-9. 2009
    ..To evaluate the association between vitreous inflammatory factors and the severity of diabetic macular edema (DME)...
  53. pmc Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass, USA
    Am J Med 120:720-7. 2007
    ..Whether mild elevations of this biomarker provide prognostic information for development of clinically evident type 2 diabetes and cardiovascular disease among individuals at usual risk for these disorders is uncertain...
  54. ncbi A new look at screening and diagnosing diabetes mellitus
    Christopher D Saudek
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Clin Endocrinol Metab 93:2447-53. 2008
    ..This report reconsiders the criteria for diagnosing diabetes and recommends screening criteria to make case finding easier for clinicians and patients...
  55. ncbi Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in nondiabetic twins
    Robert M Cohen
    Division of Endocrinology, Medicine, General Clinical Research Center, Emergency Medicine, University of Cincinnati, Ohio, USA
    Diabetes Care 29:1739-43. 2006
    ..We therefore tested whether GG (measured A1C - A1C predicted from glycated serum proteins [GSPs]) was genetically determined and whether it accounted for the heritability of A1C...
  56. ncbi Three-year efficacy of complex insulin regimens in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:1736-47. 2009
    ..Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited...
  57. ncbi C-reactive protein and glycemic control in adults with diabetes
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes Care 26:1535-9. 2003
    ..The purpose of this study was to determine the relation between CRP and HbA(1c) in a large national sample of individuals with diabetes...
  58. ncbi Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    Ralph A DeFronzo
    Division of Diabetes, University of Texas Health Science Center, San Antonio, TX, USA
    Diabetes Care 28:1092-100. 2005
    ..This study evaluates the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses...
  59. ncbi Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    M B Toft-Nielsen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 86:3717-23. 2001
    ..We conclude that the meal-related glucagon-like peptide-1 response in type 2 diabetes is decreased, which may contribute to the decreased incretin effect in type 2 diabetes...
  60. pmc Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c
    Robert M Cohen
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267 0547, USA
    Blood 112:4284-91. 2008
    ..HbA1c synthesis was linear and correlated with mean whole blood HbA1c (R(2) = 0.91). The observed variation in RBC survival was large enough to cause clinically important differences in HbA1c for a given mean blood glucose...
  61. ncbi The prevalence of retinopathy in an unselected population of type 2 diabetes patients from Arhus County, Denmark
    Marianne N Hove
    Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark
    Acta Ophthalmol Scand 82:443-8. 2004
    ..To determine the prevalence of diabetic retinopathy and the causes of visual impairment in an unselected population of type 2 diabetes patients, and to describe the risk factors for developing diabetic retinopathy in this population...
  62. ncbi Progressive hypoglycemia's impact on driving simulation performance. Occurrence, awareness and correction
    D J Cox
    Behavioral Medicine Center, University of Virginia Health System, Charlottesville 22908, USA
    Diabetes Care 23:163-70. 2000
    ..This study evaluated the blood glucose (BG) levels at which driving was impaired, impairment was detected, and corrective action was taken by subjects, along with the mechanisms underlying these three issues...
  63. ncbi Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes
    N Ahmed
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Diabetologia 48:1590-603. 2005
    ....
  64. ncbi Association of numeracy and diabetes control
    Kerri Cavanaugh
    Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA
    Ann Intern Med 148:737-46. 2008
    ..The influence of a patient's quantitative skills (numeracy) on the management of diabetes is only partially understood...
  65. ncbi Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial
    Ronald J Sigal
    University of Ottawa, Clinical Epidemiology Program, Ottawa Health Research Institute, and Prevention and Rehabilitation Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Intern Med 147:357-69. 2007
    ..However, none could assess incremental effects of combined aerobic and resistance training compared with either type of exercise alone...
  66. ncbi A randomized trial of a primary care-based disease management program to improve cardiovascular risk factors and glycated hemoglobin levels in patients with diabetes
    Russell L Rothman
    Division of General Internal Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Am J Med 118:276-84. 2005
    ..To assess the efficacy of a pharmacist-led, primary care-based, disease management program to improve cardiovascular risk factors and glycated hemoglobin (A(1C)) levels in vulnerable patients with poorly controlled diabetes...
  67. ncbi Hemodialyzed type I and type II diabetic patients in the US: Characteristics, glycemic control, and survival
    M E Williams
    Renal Unit, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts, USA
    Kidney Int 70:1503-9. 2006
    ..More studies are needed to refine recommendations for the role of HgbA1c and glycemic control in this patient population...
  68. ncbi Hypoglycaemia in insulin-treated Type 2 diabetes: frequency, symptoms and impaired awareness
    J N Henderson
    Department of Diabetes, Royal Infirmary, Edinburgh, UK
    Diabet Med 20:1016-21. 2003
    ..A retrospective survey was made of 215 people with insulin-treated Type 2 diabetes to quantify the frequency and nature of hypoglycaemia experienced...
  69. ncbi Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial
    M A Nauck
    Diabeteszentrum Bad Lauterberg im Harz, Bad Lauterberg, Germany
    Diabetes Obes Metab 9:194-205. 2007
    ..To compare the efficacy and safety of sitagliptin vs. glipizide in patients with type 2 diabetes and inadequate glycaemic control [haemoglobin A(1c) (HbA(1c)) > or = 6.5 and < or = 10%] on metformin monotherapy...
  70. ncbi Patients' participation in medical care: effects on blood sugar control and quality of life in diabetes
    S Greenfield
    Department of Medicine, University of California, Los Angeles
    J Gen Intern Med 3:448-57. 1988
    ..Experimental patients reported significantly fewer function limitations. The authors conclude that the intervention is feasible and that it changes patient behavior, improves blood sugar control, and decreases functional limitations...
  71. ncbi Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1349-54. 2008
    ..To explore the possibility that oscillating glucose may outweigh A1C levels in determining the risk for cardiovascular diabetes complications...
  72. ncbi The Pathways Study: a randomized trial of collaborative care in patients with diabetes and depression
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98195 6560, USA
    Arch Gen Psychiatry 61:1042-9. 2004
    ..Depression has been shown to be associated with poor self-management (adherence to diet, exercise, checking blood glucose levels) and high hemoglobin A1c (HbA1c) levels in patients with diabetes...
  73. ncbi Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective
    G W Taylor
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Ann Periodontol 6:99-112. 2001
    ....
  74. ncbi Is the measurement of glycated hemoglobin A1c alone an efficient screening test for undiagnosed diabetes? Japan National Diabetes Survey
    Tomoko Nakagami
    Diabetes Center, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Diabetes Res Clin Pract 76:251-6. 2007
    ..The measurement of HbA1c alone may be efficient to screen undiagnosed DM and the cut-off point of 5.6% might be proper with respect to screening tests properties for undiagnosed DM, and prediction of vascular complications in Japan...
  75. pmc Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
    Anne Thea McGill
    University of Auckland Human Nutrition Unit, University of Auckland, Auckland, New Zealand
    Nutr J 7:4. 2008
    ..In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se...
  76. pmc The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmology 115:1859-68. 2008
    ..To examine the 25-year cumulative progression and regression of diabetic retinopathy (DR) and its relation to various risk factors...
  77. ncbi Structured patient education: the diabetes X-PERT Programme makes a difference
    T A Deakin
    Nutrition and Dietetic Department, Burnley, Pendle and Rossendale Primary Care Trust, East Lancashire, UK
    Diabet Med 23:944-54. 2006
    ..To develop a patient-centred, group-based self-management programme (X-PERT), based on theories of empowerment and discovery learning, and to assess the effectiveness of the programme on clinical, lifestyle and psychosocial outcomes...
  78. ncbi Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use
    Graham P Leese
    Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Diabetes Care 26:1176-80. 2003
    ..To determine the incidence, predisposing factors, and costs of emergency treatment of severe hypoglycemia in people with type 1 and type 2 diabetes...
  79. ncbi Exenatide versus glibenclamide in patients with diabetes
    G Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Diabetes Technol Ther 12:233-40. 2010
    ..The aim of our study was to evaluate the effects of exenatide compared to glibenclamide on body weight, glycemic control, beta-cell function, insulin resistance, and inflammatory state in patients with diabetes...
  80. ncbi Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats
    E Teixeira de Lemos
    Therapeutics Unit, Institute of Pharmacology and Experimental Therapeutics, Medicine Faculty, Coimbra University, Coimbra, Portugal Polytechnic Institute of Viseu, Viseu, Portugal
    Nutrition 25:330-9. 2009
    ....
  81. ncbi Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels
    Hans J Woerle
    Department of Internal Medicine II, Clinical Research Unit CRU, Ludwig Maximilian University Munich, Grosshadern Marchioninistr 15, Munich 81377, Germany
    Diabetes Res Clin Pract 77:280-5. 2007
    ..Cross-sectional studies suggest that attainment of HbA1c goals requires specific targeting of postprandial hyperglycemia...
  82. pmc The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
    Patricia A Cleary
    Diabetes Unit, Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114 2698, USA
    Diabetes 55:3556-65. 2006
    ..Prior intensive diabetes treatment during the DCCT was associated with less atherosclerosis, largely because of reduced levels of A1C during the DCCT...
  83. pmc Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation
    Paramjit K Khera
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Diabetes 57:2445-52. 2008
    ..To determine whether interindividual heterogeneity in the erythrocyte (red blood cell [RBC]) transmembrane glucose gradient might explain discordances between A1C and glycemic control based on measured fructosamine...
  84. ncbi Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    John B Buse
    Diabetes Care Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Diabetes Care 27:2628-35. 2004
    ..This study evaluated the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing maximally effective doses of a sulfonylurea as monotherapy...
  85. ncbi Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes
    James Mu
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA
    Eur J Pharmacol 623:148-54. 2009
    ..The ability of sitagliptin to enhance islet cell function may offer insight into the potential for disease modification...
  86. ncbi Independent association of HbA(1c) and incident cardiovascular disease in people without diabetes
    Robert J Adams
    University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, South Australia, Australia
    Obesity (Silver Spring) 17:559-63. 2009
    ..Unlike previous studies, this relationship was not substantially attenuated by other traditional risk factors...
  87. ncbi Glycaemic control among patients with type 2 diabetes mellitus in seven European countries: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study
    F Alvarez Guisasola
    Centro de Salud La Calzada II, Gijon, Spain
    Diabetes Obes Metab 10:8-15. 2008
    ....
  88. ncbi Trends in prevalence and outcomes of pregnancy in women with pre-existing type I and type II diabetes
    R Bell
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BJOG 115:445-52. 2008
    ..To describe recent trends in prevalence, outcomes and indicators of care for women with pre-existing type I or type II diabetes...
  89. ncbi Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
    Michael W Steffes
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Diabetes Care 26:832-6. 2003
    ..Also, continuing C-peptide (insulin) secretion is important in avoiding hypoglycemia (the major complication of intensive diabetic therapy)...
  90. pmc Examining correlates of treatment satisfaction for injectable insulin in type 2 diabetes: lessons learned from a clinical trial comparing biphasic and basal analogues
    Meryl Brod
    The BROD GROUP, Mill Valley, CA 94941, USA
    Health Qual Life Outcomes 5:8. 2007
    ....
  91. ncbi Combined effects of hemoglobin A1c and C-reactive protein on the progression of subclinical carotid atherosclerosis: the INVADE study
    Dirk Sander
    Department of Neurology, Technical University of Munich, Munich, Germany
    Stroke 37:351-7. 2006
    ..We investigated the joint effects of both parameters on early carotid atherosclerosis progression and major vascular events in diabetic and nondiabetic subjects...
  92. ncbi Successful islet transplantation: continued insulin reserve provides long-term glycemic control
    Edmond A Ryan
    Department of Medicine, Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, 2000 College Plaza, 8215 112th Street, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 51:2148-57. 2002
    ..Islet transplantation is a reasonable option in those with severe problems with glycemic lability or hypoglycemia...
  93. ncbi Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research
    S G Grossi
    Periodontal Disease Research Center, Department of Oral Biology, School of Dental Medicine, The University at Buffalo, Buffalo, New York, USA
    Ann Periodontol 6:138-45. 2001
    ..The evidence supports the notion that treatment of chronic periodontal infection is essential in the diabetic patient. Assessment of infection status in diabetic patients is fundamental for appropriate treatment decisions...
  94. ncbi The effectiveness of depression care management on diabetes-related outcomes in older patients
    John W Williams
    Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, and Duke University School of Medicine, Durham, North Carolina 27705, USA
    Ann Intern Med 140:1015-24. 2004
    ..Depression frequently occurs in combination with diabetes mellitus, adversely affecting the course of illness...
  95. ncbi Clinical and psychological course of diabetes from adolescence to young adulthood: a longitudinal cohort study
    K S Bryden
    University Department of Paediatrics, John Radcliffe Hospital, Oxford
    Diabetes Care 24:1536-40. 2001
    ..15, SEM (beta) 0.04, P < 0.001, 95% CI 0.07-0.24). CONCLUSIONS: The outcome for this cohort was generally poor. Behavioral problems in adolescence seem to be important in influencing later glycemic control...
  96. pmc A randomized trial comparing telemedicine case management with usual care in older, ethnically diverse, medically underserved patients with diabetes mellitus
    Steven Shea
    Department of Medicine, 630 W 168th Street, New York, NY 10032, USA
    J Am Med Inform Assoc 13:40-51. 2006
    ..Telemedicine is a promising but largely unproven technology for providing case management services to patients with chronic conditions who experience barriers to access to care or a high burden of illness...
  97. ncbi Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial
    Curt L Rohlfing
    Department of Child Health, University of Missouri School of Medicine, 1 Hospital Drive M772, Columbia, MO 65203, USA
    Diabetes Care 25:275-8. 2002
    ..To define the relationship between HbA(1c) and plasma glucose (PG) levels in patients with type 1 diabetes using data from the Diabetes Control and Complications Trial (DCCT)...
  98. ncbi Glycaemic control and severe hypoglycaemia following training in flexible, intensive insulin therapy to enable dietary freedom in people with type 1 diabetes: a prospective implementation study
    A Sämann
    Department of Internal Medicine III, Friedrich Schiller University, Erlanger Allee 101, D 07740, Jena, Germany
    Diabetologia 48:1965-70. 2005
    ..The aim of this study was to evaluate the implementation of a course teaching flexible, intensive insulin therapy on glycaemic control and severe hypoglycaemia in routine care...
  99. ncbi Impact of glycemic control on survival of diabetic patients on chronic regular hemodialysis: a 7-year observational study
    Takeshi Oomichi
    Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate Medical School, 1 4 3, Asahi machi, Osaka, Japan 545 8585
    Diabetes Care 29:1496-500. 2006
    ..To investigate the impact of glycemic control during regular hemodialysis on the survival of diabetic patients with chronic kidney disease (CKD) in a longitudinal observational study...
  100. ncbi Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
    JianPing Weng
    Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Lancet 371:1753-60. 2008
    ....
  101. ncbi Predictors of glycemic control and short-term adverse outcomes in youth with type 1 diabetes
    B S Levine
    Pediatric and Adolescent Unit and the Section of Genetics and Epidemiology, Joslin Diabetes Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 139:197-203. 2001
    ..CONCLUSION: Despite improvements in diabetes care, the incidence of short-term adverse events in children with type 1 diabetes remains high, particularly in those with poorest glycemic control...

Research Grants63

  1. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..We also test if there is effect modification of APOE alleles on the association between ELCS &later-life biomarkers. ..
  2. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..The goal of this study is to assist in meeting the Healthy People 2020 objectives (D 2-14) for Hmong community members with Type 2 diabetes mellitus and improve health outcomes. ..
  3. A simple dietary message to improve dietary quality for metabolic syndrome
    Yunsheng Ma; Fiscal Year: 2012
    ..We hypothesize that a message promoting high fiber intake may be the simple message that has potential to produce broad impact. ..
  4. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..The Awardee will also continue to organize trainee workshops in neglected areas such as project management, principles of neuropsvcholoav for non-psvcholoaists. and scientific writing skills. ..
  5. Effectiveness of Second Line Hypoglycemic Medications Among Veterans
    Christianne Roumie; Fiscal Year: 2013
    ..The research team is poised to conduct a rigorous study on the safety and clinical effectiveness of second line therapies for DM. ..
  6. Metabolic Actions of Brain Leptin Receptors Signaling in Type 1 Diabetes
    Roberto Coppari; Fiscal Year: 2012
    ....
  7. Use of Continuous Glucose Sensors in Adolescents with Inadequate Diabetic Control
    Tim Wysocki; Fiscal Year: 2013
    ..These results could demonstrate that adolescents with previously suboptimal diabetic control could realize multiple benefits from CGS use if they are provided with a specialized behavioral intervention. ..
  8. Genome-Wide Association Study of Cognitive Decline Among Older African Americans
    Jill R Murrell; Fiscal Year: 2010
    ..The purpose is to identify genetic factors that are related to this important problem in this under-studied segment of the population. ..
  9. Medtable: An EMR Strategy to Promote Patient Medication Understanding and Use
    Daniel G Morrow; Fiscal Year: 2012
    ..Such a system should mitigate the impact of inadequate health literacy on patients'health behaviors and outcomes. ..
  10. Exploring CBT-DM's Absoulte and Relative Efficacy for Depressed T1DM Latino Youth
    Eduardo Cumba; Fiscal Year: 2013
    ..The revised CBT-DM manual for T1DM Latino youth would also be an innovative clinical tool that could enhance the prevention of mood disorders and the reduction of health disparities in this minority group. ..
  11. Longitudinal Aging Biomarker Study in India (LASI-Biomarkers)
    Jinkook Lee; Fiscal Year: 2012
    ....
  12. Church-based Community Diabetes Education Targeting Underserved African Americans
    KATHRYN W HOSIG; Fiscal Year: 2013
    ....
  13. Guideline Adherence and Short/Long-term Health Outcomes in Patients with Diabetes
    Maureen A Smith; Fiscal Year: 2013
    ..Overall, the results from our investigation will impact diabetes treatment guidelines, development of quality metrics, construction of pay-for-performance thresholds, and targeting of interventions. ..
  14. Diabetic Microangiopathy and Alveolar O2 Transport
    Connie C W Hsia; Fiscal Year: 2010
    ..Given the current intense interest in the development of inhaled insulin therapy, there is a growing need to understand the effects of diabetic progression and treatment on lung function. ..
  15. SmartInsulin ADME and IND-enabling Preclinical Studies
    TODD C ZION; Fiscal Year: 2010
    ..SmartInsulin is designed to provide tighter glycemic control, lowered HbA1c levels, and thus decreased incidence of diabetic complications. ..
  16. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  17. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ....
  18. DYNAMICS OF RETINOPATHY AMONG MEXICAN AMERICAN DIABETICS
    Craig Hanis; Fiscal Year: 1990
    ..Such results will suggest intermediate points at which intervention could be aimed to alter the progression and lessen the impact of retinopathy...
  19. Guideline Adherence and Health Outcomes in Medicare FFS Patients with Diabetes
    Maureen Smith; Fiscal Year: 2009
    ..The results from our investigation will have important implications for diabetes treatment guidelines, development of quality metrics and pay-for-performance efforts, and targeting of quality improvement interventions. ..
  20. PERIPHERAL ARTERIAL DISEASE IN THE DIABETIC
    Pasquale Palumbo; Fiscal Year: 1980
    ..It may point the way to new modes of treatment for this crippling complication of diabetes. ..
  21. PrEP and ART adherence monitoring using dried blood spots
    PETER LINDSAY ANDERSON; Fiscal Year: 2013
    ..We believe that TFV-DP in DBS, as a new quantitative measure of adherence, has the potential to make an immediate and lasting public health impact. ..
  22. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..In addition, the development of rapid, accurate, and predictive tests of islet viability and function post isolation will contribute to significant improvements in post transplant success. ..
  23. DIABETES SELF-MANAGEMENT OUTCOMES: A META-ANALYSIS
    Sandra Upchurch; Fiscal Year: 2001
    ..Results of the meta-analysis will be used by the Principal Investigator to design a diabetes self-management education intervention. ..
  24. CELLULAR BIOMARKERS OF AGING
    Paul Davis; Fiscal Year: 1992
    ..The advantages of the biomarkers proposed are their nonlethality, minimal invasiveness, relative simplicity and prospect for longitudinal application. Support currently exists for relevance to human aging of the proposed biomarkers...
  25. IMPROVING DIABETES CARE COLLABORATIVELY IN THE COMMUNITY
    Marshall Chin; Fiscal Year: 2001
    ..While the interventions are designed to succeed in the particularly challenging CHC setting, the findings should be generalizable to health systems with more resources and to other chronic diseases. ..
  26. The Barbados Study of Ocular Conditions (BSOC)
    Suh Yuh Wu; Fiscal Year: 2005
    ..The considerably high participation in the cohort (84% in BES, 85% in BISED, and 81% in BISED II), as well as the experience of the research team support the feasibility and yield of the proposed study. ..
  27. PSYCHOLOGICAL ADJUSTMENT & METABOLIC CONTROL IN LATINOS
    JEANNETTE ROSSELLO; Fiscal Year: 2001
    ..This will ultimately result in healthier IDDM youth, less hospitalizations, and fewer diabetic complications. ..
  28. EARLY DETECTION OF DIABETIC CARDIOMYOPATHY WITH MRI
    Christine Lorenz; Fiscal Year: 1999
    ....
  29. IMPACT OF CONTINUITY ON QUALITY OF CARE FOR DIABETES
    James Gill; Fiscal Year: 1999
    ..We will also examine whether this impact differs across health plan types and physician specialties. ..
  30. BIOFEEDBACK RELAXATION CONTROL OF DIABETES
    Angele McGrady; Fiscal Year: 1993
    ....
  31. ZINC ABSORPTION IN DIABETIC PREGNANT WOMEN
    Janet King; Fiscal Year: 1992
    ..In that case, further studies of the relationship between maternal zinc status and pregnancy outcome in the diabetic would be warranted...
  32. HIGH GLYCEMIC DIET AND RISK OF NIDDM AND CHD
    Simin Liu; Fiscal Year: 2002
    ..Through the process, Dr. Liu will acquire ample skills and experience to become an independent clinician scientist and educator in the field of nutrition and chronic disease prevention and control. ..
  33. PATHOGENESIS OF MICROANGIOPATHY IN DIABETES
    JOHN SOELDNER; Fiscal Year: 1980
    ....
  34. Diabetic Retinopathy Screening in a Primary Care Setting
    JULI DEAN; Fiscal Year: 2003
    ..b) To assess visual function and vision-specific quality of life in the DR screening cohort. ..
  35. FAMILY, AUTONOMY AND SELF-CARE IN ADOLESCENTS WITH IDDM
    Carol Dashiff; Fiscal Year: 2003
    ..Model fit will be evaluated by several methods, including goodness of fit and diagnostic plots of individual subject slopes. ..
  36. DIABETES EDUCATION MULTIMEDIA FOR VULNERABLE POPULATIONS
    Ben Gerber; Fiscal Year: 2002
    ..Also, patient and staff satisfaction with computer usage for diabetes education will be evaluated. ..
  37. COMPLIANCE AND CONTROL IN CHILDHOOD DIABETES
    Suzanne Johnson; Fiscal Year: 1999
    ....
  38. Alcohol-specific modifications of glycated Hb: Novel biomarkers of alcohol abuse
    Yousef Al Abed; Fiscal Year: 2007
    ..Future studies will be designed to measure these alcohol-specific-markers in humans following binge and chronic alcohol intake. [unreadable] [unreadable] [unreadable]..
  39. Neighborhood Poverty, Health and Economic Security Over the Adult Lifespan
    Jens Ludwig; Fiscal Year: 2010
    ..This study will help shed light on larger disparities in health and economic outcomes across race and class lines. NIA funding is essential to administer the full range of outcomes described here to all MTO adults. ..
  40. Canine Studies to Restore Endogenous Insulin
    B Ligon; Fiscal Year: 2009
    ..If proven safe and effective, this treatment could be a major advance forward in therapeutic interventions for both type 1 and type 2 diabetes. ..
  41. Home-Based Diabetes Symptom Self-Management for Mexican Americans
    Alexandra Garcia; Fiscal Year: 2009
    ....
  42. AUTOMATED ASSESSMENTS AND THE QUALITY OF DIABETES CARE
    John Piette; Fiscal Year: 2002
    ..abstract_text> ..
  43. Blood Pressure, cholestrol, and glycemic control
    Paul Muntner; Fiscal Year: 2006
    ..abstract_text> ..
  44. Dietary Education for Rural, Black Persons with Diabetes
    Wanda Anderson Loftin; Fiscal Year: 2001
    ..Self-reported data will be collected with the Food Habits and the Costs of Care questionnaires. Repeated measures MANOVA and repeated measures ANOVA will be used to analyze the data. ..
  45. DIABETES PATIENT EDUCATION IN RURAL HISPANIC COMMUNITY
    Sharon Brown; Fiscal Year: 1992
    ....
  46. WEIGHT LOSS/EXERCISE IN AGED BLACKS WITH CHRONIC DISEASE
    TANYA AGURS; Fiscal Year: 1991
    ....
  47. PATHOBIOLOGICAL DETERMINANTS OF ATHEROSCLEROSIS IN YOUTH
    Jack Strong; Fiscal Year: 1992
    ..This study of the "Pathobiological Determinants of Atherosclerosis in Youth" should provide detailed quantitative information concerning association of risk factors with arterial lesions in this important age group...
  48. THERAPY IN IDDM ADOLESCENTS IN POOR METABOLIC CONTROL
    Deborah Ellis; Fiscal Year: 2000
    ..If successful, this intervention will provide immediate assistance to a vulnerable population at high risk for diabetes complications and decreased quality of life. ..
  49. RNA-Biopolymer Nanostructures for Smart Insulin Delivery
    TODD ZION; Fiscal Year: 2005
    ..Thus, Smartlnsulin seeks to provide tighter glycemic control, lowered HbA1c levels, and decreased incidence of diabetic complications. ..
  50. Pilot Study of Vedic Medicine for Type 2 Diabetes
    Charles Elder; Fiscal Year: 2004
    ..This study is significant in being the first randomized controlled trial to evaluate a multi-modality MVM protocol for the management of type 2 diabetes ..
  51. Glucose-Responsive Self-Regulated Insulin Delivery
    TODD ZION; Fiscal Year: 2005
    ..and pharmacodynamic parameters - Optimize Smartlnsulin formulation to control fasting and mealtime glucose levels using a single dose - Reduce 60-day HbA1c levels with daily injections of optimized Smartlnsulin ..
  52. Nanoparticle, Raman-based Fiber-optic Glucose Sensor
    Joseph Walsh; Fiscal Year: 2004
    ..abstract_text> ..
  53. Nanoparticle, Raman-based Fiber-optic Glucose Sensor
    Joseph Walsh; Fiscal Year: 2006
    ..abstract_text> ..
  54. SmartInsulin Stability, Process Development, Assay Validation and GMP Manufacturi
    TODD ZION; Fiscal Year: 2009
    ..SmartInsulin is designed to provide tighter control of blood sugar levels and thus decreased incidence of diabetic complications. ..
  55. Family Function & Diet Quality in Women with Diabetes
    Natasha Greene; Fiscal Year: 2006
    ..Multiple regressions will be used to determine significant predictors of dietary intake quality and glycosylated hemoglobin. [unreadable] [unreadable] [unreadable]..
  56. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  57. THE 4 CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    Kathy Baumgartner; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  58. Safety Profile Optimization of Glucose-Regulated Insulin Formulations
    TODD ZION; Fiscal Year: 2006
    ..Thus, Smartlnsulin seeks to provide tighter glycemic control, lowered HbA1c levels, and decreased incidence of diabetic complications. [unreadable] [unreadable] [unreadable]..
  59. FOUR-CORNERS BREAST CANCER STUDY
    Tim Byers; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  60. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    Maria Martinez; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  61. RISK FACTORS FOR UTI IN POST MENOPAUSAL WOMEN
    Stephan Fihn; Fiscal Year: 2001
    ..Diabetic patients will be followed with glycosylated hemoglobin at least annually. Patients will monitor their urine monthly at home with leukocyte esterase/nitrite dipsticks and make a clinic visit if they test positive. ..
  62. Diabetes and Cardiovascular Risks in Primary Care
    Michael Parchman; Fiscal Year: 2005
    ....