glucosides

Summary

Top Publications

  1. pmc Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas, USA
    Diabetes Care 35:1232-8. 2012
  2. pmc Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    K Stenlof
    Clinical Trial Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Diabetes Obes Metab 15:372-82. 2013
  3. ncbi Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    D Devineni
    Janssen Research and Development, LLC, Raritan, NJ 08869, USA
    Diabetes Obes Metab 14:539-45. 2012
  4. ncbi Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    S Sha
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA
    Diabetes Obes Metab 13:669-72. 2011
  5. pmc Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 33:2217-24. 2010
  6. pmc Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    Yin Liang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Spring House, Pennsylvania, United States of America
    PLoS ONE 7:e30555. 2012
  7. ncbi Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
    Clifford J Bailey
    Life and Health Sciences, Aston University, Birmingham, UK
    Lancet 375:2223-33. 2010
  8. pmc Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat
    Ze qiang Qu
    Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e29641. 2012
  9. ncbi Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Imadegawa dori, Kamigyo ku, Kyoto 602 8580, Japan
    J Nutr 133:2125-30. 2003
  10. pmc 454 pyrosequencing based transcriptome analysis of Zygaena filipendulae with focus on genes involved in biosynthesis of cyanogenic glucosides
    Mika Zagrobelny
    Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, DK 1871 Frederiksberg C, Copenhagen, Denmark
    BMC Genomics 10:574. 2009

Detail Information

Publications377 found, 100 shown here

  1. pmc Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas, USA
    Diabetes Care 35:1232-8. 2012
    ..To evaluate the effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, in type 2 diabetes mellitus inadequately controlled with metformin monotherapy...
  2. pmc Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    K Stenlof
    Clinical Trial Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Diabetes Obes Metab 15:372-82. 2013
    ..Canagliflozin is a sodium glucose co-transporter 2 inhibitor in development for type 2 diabetes mellitus (T2DM). The efficacy and safety of canagliflozin were evaluated in subjects with T2DM inadequately controlled with diet and exercise...
  3. ncbi Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    D Devineni
    Janssen Research and Development, LLC, Raritan, NJ 08869, USA
    Diabetes Obes Metab 14:539-45. 2012
    ..Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that is being investigated for the treatment of type 2 diabetes mellitus (T2DM)...
  4. ncbi Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    S Sha
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA
    Diabetes Obes Metab 13:669-72. 2011
    ..Canagliflozin was generally well tolerated; most adverse events were mild and no hypoglycaemia was reported. These results support further study of canagliflozin...
  5. pmc Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 33:2217-24. 2010
    ..We evaluated the efficacy and safety of dapagliflozin in treatment-naive patients with type 2 diabetes...
  6. pmc Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    Yin Liang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Spring House, Pennsylvania, United States of America
    PLoS ONE 7:e30555. 2012
    ..Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM)...
  7. ncbi Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
    Clifford J Bailey
    Life and Health Sciences, Aston University, Birmingham, UK
    Lancet 375:2223-33. 2010
    ..We assessed the efficacy and safety of dapagliflozin in patients who have inadequate glycaemic control with metformin...
  8. pmc Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat
    Ze qiang Qu
    Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e29641. 2012
    ..Our findings indicated that the RCE improved the impaired hippocampal neurogenesis in the rat model of AD through protecting NSCs by its main ingredient salidroside which scavenged intracellular ROS...
  9. ncbi Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Imadegawa dori, Kamigyo ku, Kyoto 602 8580, Japan
    J Nutr 133:2125-30. 2003
    ..Our findings provide a biochemical and nutritional basis for the use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of obesity and diabetes...
  10. pmc 454 pyrosequencing based transcriptome analysis of Zygaena filipendulae with focus on genes involved in biosynthesis of cyanogenic glucosides
    Mika Zagrobelny
    Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, DK 1871 Frederiksberg C, Copenhagen, Denmark
    BMC Genomics 10:574. 2009
    ..They both contain cyanogenic glucosides which liberate toxic hydrogen cyanide upon breakdown...
  11. ncbi Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
    R Grempler
    CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Diabetes Obes Metab 14:83-90. 2012
    ..This study assessed pharmacological properties of empagliflozin in vitro and pharmacokinetic properties in vivo and compared its potency and selectivity with other SGLT-2 inhibitors...
  12. pmc Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial
    Michael A Nauck
    Diabetes Centre, Bad Lauterberg, Germany
    Diabetes Care 34:2015-22. 2011
    ..We compared the efficacy, safety, and tolerability of dapagliflozin with the sulfonylurea glipizide in patients with type 2 diabetes inadequately controlled with metformin monotherapy...
  13. pmc Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    James F List
    Global Clinical Research, Bristol Myers Squibb, Princeton, New Jersey, USA
    Diabetes Care 32:650-7. 2009
    ..In this multiple-dose study we evaluated the safety and efficacy of dapagliflozin in type 2 diabetic patients...
  14. ncbi Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway
    Xiaofeng Li
    Laboratory of Senile Encephalopathy with the Integrated Traditional Chinese Medicine and Western Medicine, Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi an 710032, People s Republic of China
    Brain Res 1382:9-18. 2011
    ..Our results show that the protective effects of salidroside on PC12 cells are mediated, at least in part, by inhibition of the NO pathway...
  15. ncbi The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    Bernd Bufe
    Department of Molecular Genetics, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Potsdam Rehbrücke, Germany
    Nat Genet 32:397-401. 2002
    ..If the ability of TAS2R16 to detect substances with common molecular properties is typical of the bitter receptor family, it may explain how a few receptors permit the perception of numerous bitter substances...
  16. ncbi Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    Jan Bolinder
    Department of Endocrinology, Metabolism, and Diabetes, Karolinska University Hospital Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden
    J Clin Endocrinol Metab 97:1020-31. 2012
    ..Dapagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, reduces hyperglycemia in patients with type 2 diabetes mellitus (T2DM) by increasing urinary glucose excretion, and weight loss is a consistent associated finding...
  17. ncbi Masked mycotoxins: determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatography-tandem mass spectrometry
    Franz Berthiller
    Christian Doppler Laboratory for Mycotoxin Research and Institute for Plant Production Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Konrad Lorenz Strasse 20, A 3430 Tulln, Austria
    J Agric Food Chem 53:3421-5. 2005
    ..The synthesis products were characterized by liquid chromatography-tandem mass spectrometry. The DON-glucosides showed different collision-induced dissociation (CID) fragmentation behaviors and could therefore be ..
  18. ncbi Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial
    John P H Wilding
    University Hospital Aintree, Liverpool, United Kingdom
    Ann Intern Med 156:405-15. 2012
    ..Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2, may improve glycemic control with a lower dose of insulin and attenuate the associated weight gain in patients with inadequate control despite high doses of insulin...
  19. pmc A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment
    John P H Wilding
    University of Liverpool, School of Clinical Sciences, Liverpool, England
    Diabetes Care 32:1656-62. 2009
    ..To determine whether dapagliflozin, which selectively inhibits renal glucose reabsorption, lowers hyperglycemia in patients with type 2 diabetes that is poorly controlled with high insulin doses plus oral antidiabetic agents (OADs)...
  20. pmc ABCC1, an ATP binding cassette protein from grape berry, transports anthocyanidin 3-O-Glucosides
    Rita Maria Francisco
    University of Zurich, Institute of Plant Biology, 8008 Zurich, Switzerland
    Plant Cell 25:1840-54. 2013
    ..In conclusion, we provide evidence that ABCC1 acts as an anthocyanin transporter that depends on GSH without the formation of an anthocyanin-GSH conjugate. ..
  21. ncbi X-ray crystal structure and antioxidant activity of salidroside, a phenylethanoid glycoside
    Peizhong Yu
    Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Chem Biodivers 4:508-13. 2007
    ..e., tyrosol (=4-(2-hydroxyethyl)phenol; 2)...
  22. ncbi Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway
    Han Zhong
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
    J Pharmacol Sci 114:399-408. 2010
    ..These findings suggest that salidroside reduced ischemia-mediated myocardial damage. Salidroside therefore has potential to be a promising drug for preventing and treating myocardial ischemic diseases...
  23. ncbi Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
    Li Zhang
    Jiangsu Institute of Nuclear Medicine, 20 Qian Rong Road, Wuxi, Jiangsu 214063, China
    Eur J Pharmacol 564:18-25. 2007
    ....
  24. ncbi Cucurbitacin glucosides: antioxidant and free-radical scavenging activities
    Tehila Tannin-Spitz
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Biochem Biophys Res Commun 364:181-6. 2007
    ..We studied the antioxidant properties of cucurbitacin B + E glucosides (cucurbitacin glucoside combination, CGC) and their direct free-radical scavenging properties, using ESR ..
  25. pmc Hydrolytic fate of deoxynivalenol-3-glucoside during digestion
    Franz Berthiller
    Christian Doppler Laboratory for Mycotoxin Metabolism, Center for Analytical Chemistry, Department for Agrobiotechnology IFA Tulln, University of Natural Resources and Life Sciences, Vienna BOKU, Konrad Lorenz Str 20, 3430 Tulln, Austria
    Toxicol Lett 206:264-7. 2011
    ..Taken together these data indicate that D3G is of toxicological relevance and should be regarded as a masked mycotoxin...
  26. ncbi Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
    Sumihiro Nomura
    Medicinal Chemistry Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 2 2 50 Kawagishi, Toda, Saitama, Japan
    J Med Chem 53:6355-60. 2010
    We discovered that C-glucosides 4 bearing a heteroaromatic ring formed metabolically more stable inhibitors for sodium-dependent glucose cotransporter 2 (SGLT2) than the O-glucoside, 2 (T-1095)...
  27. ncbi Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial
    K Strojek
    Department of Internal Diseases, Diabetology and Nephrology, Silesian Medical University, Zabrze, Poland
    Diabetes Obes Metab 13:928-38. 2011
    ..We assessed the efficacy, safety and tolerability of dapagliflozin added to glimepiride in patients with uncontrolled T2DM...
  28. ncbi Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    B Komoroski
    Discovery Medicine and Clinical Pharmacology, Research and Development, Bristol Myers Squibb, Princeton, New Jersey, USA
    Clin Pharmacol Ther 85:513-9. 2009
    ..This was attributed to the decrease in filtered glucose load following improved glycemic control. Dapagliflozin produced dose-dependent increases in glucosuria and clinically meaningful changes in glycemic parameters in T2DM patients...
  29. ncbi Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin
    S Kinoshita
    Laboratory of Functional and Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Phytomedicine 14:755-62. 2007
    ..These results show that the extract of T. catappa and its antioxidant, corilagin are protective against GalN/LPS-induced liver injury through suppression of oxidative stress and apoptosis...
  30. ncbi Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    B Komoroski
    Discovery Medicine and Clinical Pharmacology, Research and Development, Bristol Myers Squibb, Princeton, New Jersey, USA
    Clin Pharmacol Ther 85:520-6. 2009
    ....
  31. ncbi Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters
    Jian Du
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, No 325 Guohe Road, Shanghai 200433, PR China
    Phytomedicine 16:652-8. 2009
    ..Experimental results also showed that polydatin elevated LDL-C/HDL-C and TC/HDL-C ratios. In concert with other effects, serum cholesterol-lowering effect in hamsters may contribute to the regulation properties attributed to polydatin...
  32. ncbi Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in Japanese subjects without and with type 2 diabetes mellitus
    S Kasichayanula
    Bristol Myers Squibb Company, Rt 206 and Province Line Road, Princeton, NJ 08543 4000, USA
    Diabetes Obes Metab 13:357-65. 2011
    ..Here, the pharmacokinetics (PK) and pharmacodynamics (PD) of dapagliflozin were evaluated in healthy Japanese subjects and in Japanese subjects with T2DM...
  33. ncbi Metabolites of the ellagitannin geraniin and their antioxidant activities
    Hideyuki Ito
    Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Planta Med 77:1110-5. 2011
    ..These findings suggest that these metabolites may contribute to the health benefits of ellagitannins as antioxidants in the body...
  34. pmc Biosynthesis of the cyanogenic glucosides linamarin and lotaustralin in cassava: isolation, biochemical characterization, and expression pattern of CYP71E7, the oxime-metabolizing cytochrome P450 enzyme
    Kirsten Jørgensen
    Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, Villum Kahn Rasmussen Research Centre Pro Active Plants, University of Copenhagen, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 155:282-92. 2011
    ..Manihot esculenta) is a eudicotyledonous plant that produces the valine- and isoleucine-derived cyanogenic glucosides linamarin and lotaustralin with the corresponding oximes and cyanohydrins as key intermediates...
  35. ncbi Arabidopsis thaliana beta-Glucosidases BGLU45 and BGLU46 hydrolyse monolignol glucosides
    Luis L Escamilla-Trevino
    Department of Biological Sciences, The University of Iowa, 108 Biology Building, Iowa City, IA 52242, USA
    Phytochemistry 67:1651-60. 2006
    ..to the hypothesis that their respective gene products may be involved in lignification by hydrolysing monolignol glucosides. To test this hypothesis, we cloned cDNAs encoding BGLU45 and BGLU46 and expressed them in Pichia pastoris...
  36. ncbi Salidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathway
    Ye Zhu
    Department of Cardiology, Molecular Medicine Research Center, State Key Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
    DNA Cell Biol 30:809-19. 2011
    ..Our results indicated that salidroside protected cardiomyocytes against oxidative injury through activating the PI3K/Akt pathway and increasing the expression and activities of endogenous PI3K dependent antioxidant enzymes...
  37. ncbi Protective role of salidroside against aging in a mouse model induced by D-galactose
    Gen xiang Mao
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Biomed Environ Sci 23:161-6. 2010
    ..To investigate the protective effects of putative AGEs (advanced glycation endproducts) inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose...
  38. ncbi Temporal coding mediates discrimination of "bitter" taste stimuli by an insect
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, New York 10027, USA
    J Neurosci 26:8900-8. 2006
    ..We found that the pattern of stimulus generalization in both intact and lat-ablated caterpillars could only be predicted by temporal coding. We conclude that temporal codes from the periphery can mediate discriminative taste processing...
  39. ncbi N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana
    Bingkai Hou
    CNAP, Department of Biology, University of York, York YO10 5DD, United Kingdom
    J Biol Chem 279:47822-32. 2004
    Cytokinins are plant hormones that can be glucosylated to form O-glucosides and N-glucosides. The glycoconjugates are inactive and are thought to play a role in homeostasis of the hormones...
  40. ncbi Identification and characterization of new Fusarium masked mycotoxins, T2 and HT2 glycosyl derivatives, in naturally contaminated wheat and oats by liquid chromatography-high-resolution mass spectrometry
    Veronica M T Lattanzio
    Institute of Sciences of Food Production ISPA, National Research Council of Italy CNR, Via G Amendola 122 o, 70126, Bari, Italy
    J Mass Spectrom 47:466-75. 2012
    ..The present work confirms the widespread occurrence of trichothecene glucosides in cereal grains naturally contaminated with the relevant unconjugated toxins, thus suggesting the importance of ..
  41. ncbi Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor
    Paul Nyirjesy
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Curr Med Res Opin 28:1173-8. 2012
    ..Vaginal Candida colonization and symptomatic vulvovaginal adverse events (VVAE) were assessed in females with T2DM treated with canagliflozin, a SGLT2 inhibitor...
  42. ncbi Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study
    Lindsay E Nicolle
    University of Manitoba, Winnipeg, Canada
    Curr Med Res Opin 28:1167-71. 2012
    ..To examine the effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor that lowers blood glucose by increasing urinary glucose excretion (UGE), on asymptomatic bacteriuria and urinary tract infections (UTIs)...
  43. ncbi Base J: discovery, biosynthesis, and possible functions
    Piet Borst
    Center of Biomedical Genetics, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Annu Rev Microbiol 62:235-51. 2008
    ....
  44. pmc Why Do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
    Jiwen Jim Liu
    Medicinal Chemistry, Amgen, Inc, South San Francisco, California, USA
    Diabetes 61:2199-204. 2012
    ....
  45. ncbi Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease
    Lan Zhang
    Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, China
    Restor Neurol Neurosci 31:41-52. 2013
    ....
  46. ncbi Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
    T Heise
    Profil, Hellersbergstrasse 9, Neuss, Germany
    Diabetes Obes Metab 15:613-21. 2013
    ..To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of empagliflozin in patients with type 2 diabetes following oral administration of 10, 25 or 100 mg doses once daily over 28 days...
  47. ncbi Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation
    Giulia Lanzilli
    Institute of Translational Pharmacology IFT, National Council of Research, Rome, Via Fosso del Cavaliere 100, 00173, Rome, Italy
    Inflammation 35:240-8. 2012
    ..This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases...
  48. ncbi Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus
    G Luippold
    Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, Biberach an der Riss, Germany
    Diabetes Obes Metab 14:601-7. 2012
    ..This study investigated effects of the SGLT-2 inhibitor, empagliflozin, alone and in combination with insulin, on glucose homeostasis in an animal model of T1DM...
  49. pmc Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial
    Clifford J Bailey
    Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    BMC Med 11:43. 2013
    ..The present study is an extension that was undertaken to evaluate dapagliflozin as long-term therapy in this population...
  50. ncbi Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway
    Cheng Zeng
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Molecules 16:8552-68. 2011
    ..The effect of THSG 60 mg·kg(-1) on PPAR-γ mRNA expression was higher than that of mesalazine. THSG may thus be a promising new candidate or lead compound for the treatment of IBD...
  51. ncbi The maltodextrin transport system and metabolism in Lactobacillus acidophilus NCFM and production of novel alpha-glucosides through reverse phosphorolysis by maltose phosphorylase
    Hiroyuki Nakai
    Enzyme and Protein Chemistry, Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    FEBS J 276:7353-65. 2009
    ....
  52. ncbi Cardioprotective effect of polydatin against ischemia/reperfusion injury: roles of protein kinase C and mito K(ATP) activation
    Qing Miao
    Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, 17 Changle West Road, 710032 Xi an, Shaanxi, PR China
    Phytomedicine 19:8-12. 2011
    ..We therefore conclude that PPC exerts cardioprotective effect by the activation of PKC-K(ATP)-dependent signaling and the direct anti-oxidative stress mechanisms...
  53. ncbi Effects of milling and baking technologies on levels of deoxynivalenol and its masked form deoxynivalenol-3-glucoside
    Marta Kostelanska
    Institute of Chemical Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Chemistry and Analysis, Technicka 3, 166 28 Prague 6, Czech Republic
    J Agric Food Chem 59:9303-12. 2011
    ..Most of these compounds were located in the crust of experimental breads...
  54. ncbi Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea
    Samuel E Schriner
    Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA
    Free Radic Res 43:836-43. 2009
    ..These results present a decrease in endogenous superoxide levels as a possible mode of action for the root extract of R. rosea...
  55. ncbi Anti-HBV active flavone glucosides from Euphorbia humifusa Willd
    Ying Tian
    Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, PR China
    Fitoterapia 81:799-802. 2010
    Thirteen flavone glucosides from the herb of Euphorbia humifusa were isolated and elucidated...
  56. ncbi Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro
    Tian Yao Shi
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Neurotox Res 21:358-67. 2012
    ..This gives a new insight into the development of therapeutic natural antioxidants against oxidative stress...
  57. ncbi Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons
    Xia Chen
    Medical School of Soochow University, JS 215123, Suzhou, People s Republic of China
    Mol Cell Biochem 332:85-93. 2009
    ..Perhaps, this study might contribute to the development of salidroside as a broad-spectrum agent for preventing and/or treating neuronal damage in neurodegenerative disorders...
  58. ncbi Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells
    Jen Yu Hung
    Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 35:141-7. 2008
    ..4. This is the first study to show that the induction of p21/WAF1 and the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of PF in A549 cells...
  59. ncbi Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats
    Xia Chen
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS, PR China
    Brain Res 1238:189-98. 2008
    ....
  60. ncbi Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus
    Wu Yong
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P R China
    Planta Med 75:1112-7. 2009
    ..Therefore, gastrodin may have potential therapeutic value for lead-induced impairments during human developmental stages...
  61. ncbi Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain
    Hui Ji
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China
    Brain Res Bull 87:50-9. 2012
    ....
  62. pmc Observation of T-2 toxin and HT-2 toxin glucosides from Fusarium sporotrichioides by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)
    Mark Busman
    U S Agricultural Research Service, National Center for Agricultural Utilization Department of Agriculture Research, Peoria, IL 61604, USA
    Toxins (Basel) 3:1554-68. 2011
    ..Production of the two glucosides was measured in kernels from wheat and oat inoculated with F...
  63. ncbi Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin
    Erin Wei Qian
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Ethnopharmacol 133:308-14. 2011
    ..Rhodiola rosea is commonly used in China and Tibet folk medicine for the treatment of high altitude sickness, anoxia and mountain malhypoxia...
  64. ncbi Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils
    Sung Jin An
    Department of Anatomy, College of Medicine, Hallym University, Chunchon, South Korea
    J Neurosci Res 71:534-43. 2003
    ..From the neuroanatomical viewpoint, these findings suggest that gastrodin may cause the elevation of GABA concentration by inhibiting the GABA shunt...
  65. pmc Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways
    Ji Nan Dai
    Department of Anatomy, Kunming Medical University, Kunming, Yunnan, China
    PLoS ONE 6:e21891. 2011
    ..The current study investigates the potential mechanisms whereby gastrodin affects the expression of potentially pro-inflammatory proteins by cultured murine microglial BV-2 cells stimulated with lipopolysaccharide (LPS)...
  66. ncbi Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure
    Ivana Serraino
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Life Sci 73:1097-114. 2003
    ....
  67. ncbi Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Kamigyo ku, Kyoto 602 8580, Japan
    Biochem Biophys Res Commun 316:149-57. 2004
    ..These data suggest that anthocyanins have a potency of unique therapeutic advantage and also have important implications for preventing obesity and diabetes...
  68. ncbi Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons
    Xiang Xu
    Department of Pharmacy, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P R China
    Planta Med 73:650-4. 2007
    ..These findings suggest that gastrodin has a neuroprotective action against hypoxia in the cultured cortical neuron, and the mechanism may involve a decreasing of the extracellular glutamate level...
  69. ncbi Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats
    Yoshikazu Fujimori
    Development Research R and D, Kissei Pharmaceutical Co, Ltd, Azumino, Japan
    Eur J Pharmacol 609:148-54. 2009
    ..These data indicate that sergliflozin etabonate could improve glycemic control without its use resulting in insulin secretion, hypoglycemia, and body weight gain, and may provide a unique approach to the treatment of diabetes...
  70. pmc Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16
    Takanobu Sakurai
    General Research Institute of Food Science and Technology, Nissin Foods Holdings Co, Ltd, Shiga 525 0058, Japan
    J Biol Chem 285:28373-8. 2010
    ..This study characterizes the molecular interaction between hTAS2R16 and beta-D-glucopyranoside and will also facilitate rational design of bitter blockers...
  71. ncbi Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells
    Li Zhang
    Jiangsu Institute of Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health, Wuxi, Jiangsu, China
    Neurochem Int 57:547-55. 2010
    ..These results suggest that salidroside has protective effects against Abeta(25-35)-induced oxidative stress, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases...
  72. ncbi Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells
    Tehila Tannin-Spitz
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Biochem Pharmacol 73:56-67. 2007
    Our aim was to study the effects of cucurbitacin glucosides extracted from Citrullus colocynthis leaves on human breast cancer cell growth. Leaves were extracted, resulting in the identification of cucurbitacin B/E glucosides...
  73. ncbi Antioxidant activity of anthocyanins and their aglycons
    Marja P Kähkönen
    Department of Applied Chemistry and Microbiology, Division of Food Chemistry, P O Box 27, FIN 00014 University of Helsinki, Finland
    J Agric Food Chem 51:628-33. 2003
    ..In LDL the aglycons showed in general higher activities than the glycosides. In bulk oil, to the contrary, the glycosides were more effective than the aglycons...
  74. ncbi Lignan glucosides from Acanthus ilicifolius
    T Kanchanapoom
    Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Japan
    Phytochemistry 56:369-72. 2001
    From the aerial part of Acanthus ilicifolius, two lignan glucosides, (+)-lyoniresinol 3a-[2-(3,5-dimethoxy-4-hydroxy)-benzoyl]-O-beta-glucopyranoside, and dihydroxymethyl-bis(3,5-dimethoxy-4-hydroxyphenyl) tetrahydrofuran-9(or 9')-O-beta-..
  75. ncbi New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity
    A Sala
    Departament de Farmacologia, , , , 46100 Burjassot, Valencia, Spain
    J Nat Prod 64:1360-2. 2001
    Three new acetophenone glucosides (4-6), three known aglycons (1-3), and a benzo-gamma-pyrone glucoside (7) were isolated from the CH(2)Cl(2), EtOAc, and BuOH extracts from the aerial parts of Helichrysum italicum...
  76. ncbi Protective effect of cyanidin 3-O-beta-D-glucoside on ochratoxin A-mediated damage in the rat
    Claudia Di Giacomo
    Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, Vle A Doria 6, 95100 Catania, Italy
    Br J Nutr 98:937-43. 2007
    ..The present study confirmed that the effects of OTA are mediated by oxidative stress and demonstrated that C3G efficiently counteracted deleterious effects of OTA because of its antioxidant and HO-1-inducing properties...
  77. pmc Binding of arabinogalactan proteins by Yariv phenylglycoside triggers wound-like responses in Arabidopsis cell cultures
    Yu Guan
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Physiol 135:1346-66. 2004
    ..It remains uncertain whether the Yariv phenylglycoside cross-linking of cell surface AGPs induces these genes through a specific AGP-based signaling mechanism or through a general mechanical perturbation of the cell surface...
  78. ncbi Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line
    Pei Ni Chen
    Institute of Biochemistry, Chung Shan Medical University, No 110, Section 1, Chien Kuo N Road, Taichung 402, Taiwan, ROC
    Cancer Lett 235:248-59. 2006
    ..Together, these result suggested that anthocyanins could decrease the in vitro invasiveness of cancer cells and therefore, may be of great value in developing a potential cancer therapy...
  79. ncbi Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation
    Ting Wang
    Department of Pharmacology, Tongji Medical College, Wuhan, Hubei 430030, China
    Free Radic Biol Med 47:229-40. 2009
    ..Our study indicates that TSG protects against cerebral ischemia/reperfusion injury through multifunctional cytoprotective pathways...
  80. ncbi Preliminary exploration on anti-inflammatory mechanism of Corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose) in vitro
    Lei Zhao
    Department of Hepatology and Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
    Int Immunopharmacol 8:1059-64. 2008
    ..Corilagin possesses a potential anti-inflammatory effect by not only abating inflammatory impairment but also promoting regression of inflammation and has a good prospect to be used in many inflammation-related diseases...
  81. pmc JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes
    Laura J Cliffe
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Nucleic Acids Res 37:1452-62. 2009
    ..Reintroduction of JBP2 in the J-null trypanosome stimulates HOMedU formation and site-specific synthesis of base J. We conclude that JBP2 and JBP1 are the TH enzymes involved in J biosynthesis...
  82. ncbi Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
    Yu Qin
    Department of Nutrition, Sun Yat Sen University, Guangzhou, China
    Am J Clin Nutr 90:485-92. 2009
    ..Anthocyanins have been shown to exert benefits on the lipid profile in many animal models. Whether these molecules have similar beneficial effects in humans is currently unknown...
  83. ncbi A maize QTL for silk maysin levels contains duplicated Myb-homologous genes which jointly regulate flavone biosynthesis
    Peifen Zhang
    Department of Zoology and Genetics, Iowa State University, Ames, IA 50011, USA
    Plant Mol Biol 52:1-15. 2003
    ..These results show that a QTL for flavone biosynthesis actually comprises two tightly linked genes with related functions...
  84. pmc Arabidopsis sucrose transporter AtSUC9. High-affinity transport activity, intragenic control of expression, and early flowering mutant phenotype
    Alicia B Sivitz
    Department of Plant Biology, University of Minnesota, St Paul, Minnesota 55108, USA
    Plant Physiol 143:188-98. 2007
    ..025 mm). AtSUC9 showed low substrate specificity, similar to AtSUC2 (At1g22710), and transported a wide range of glucosides, including helicin, salicin, arbutin, maltose, fraxin, esculin, turanose, and alpha-methyl-d-glucose...
  85. ncbi Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside
    Shuqiang Zhang
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People s Republic of China
    Mol Cell Biochem 354:161-70. 2011
    ....
  86. ncbi Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis
    Yan Chang
    Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti inflammatory and Immunopharmacology in Anhui Province, Hefei 230032, Anhui Province, China
    J Ethnopharmacol 121:43-8. 2009
    ....
  87. ncbi Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach
    Joana Paixão
    Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000 548, Coimbra, Portugal
    Apoptosis 16:976-89. 2011
    ....
  88. ncbi Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation
    Shu Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS 226001, People s Republic of China
    Cell Mol Neurobiol 28:1067-78. 2008
    ..Our findings might raise a possibility of potential therapeutic applications of salidroside for preventing and treating cerebral ischemic and neurodegenerative diseases...
  89. ncbi Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside
    Alessandra Russo
    Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania 95100, Italy
    J Nutr Biochem 16:31-7. 2005
    ..C3G (0.125, 0.250 mM) added to the cells treated with 50 microM OTA significantly reduced free radical species production and prevented genomic DNA damage...
  90. ncbi Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial
    K Kaku
    Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Okayama, Japan
    Diabetes Obes Metab 15:432-40. 2013
    ..This study assessed the efficacy and safety of dapagliflozin monotherapy in Japanese T2DM patients with inadequate glycaemic control...
  91. ncbi Structural analysis of novel bioactive acylated steryl glucosides in pre-germinated brown rice bran
    Seigo Usuki
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Lipid Res 49:2188-96. 2008
    ..report on the isolation and structural characterization of the activator lipids from PR bran as acylated steryl glucosides (ASGs)...
  92. ncbi Validated HPLC method for the standardization of Phyllanthus niruri (herb and commercial extracts) using corilagin as a phytochemical marker
    Renata Colombo
    Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil
    Biomed Chromatogr 23:573-80. 2009
    ..The method may be applied in the standardization of herbs and phytomedicines commercialized in Brazil as quebra-pedra...
  93. ncbi A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Ann Med 44:375-93. 2012
    ..Current treatment of hyperglycemia in type 2 diabetes (T2DM) is often ineffective and has unwanted effects. Therefore, novel antidiabetic drugs are under development...
  94. ncbi Galloyl, caffeoyl and hexahydroxydiphenoyl esters of dihydrochalcone glucosides from Balanophora tobiracola
    Takashi Tanaka
    Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Phytochemistry 66:675-81. 2005
    Seven galloyl, caffeoyl and (S)-hexahydroxydiphenoyl (HHDP) esters of dihydrochalcone glucosides were isolated from Balanophora tobiracola; based on spectroscopic and chemical evidence, their structures were determined to be 6''-O-galloyl-..
  95. ncbi Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions
    L Berek
    Institute of Microbiology, University of Szeged, Faculty of Medicine, Dom ter 10, 6720 Szeged, Hungary
    In Vivo 15:151-6. 2001
    ..However, ginsenosides Rc, Rd and parishin C were able to moderately reduce the activity of the efflux pump. Parishin, parishin C and crude extract significantly enhanced the ADCC reaction...
  96. ncbi Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold
    Cui Li
    School of Pharmacy, and Key Laboratory for Advanced Material and Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China
    Eur J Med Chem 46:4212-8. 2011
    ..phosphatase (PTP) 1B inhibitors based on sugar scaffolds, a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides was efficiently constructed via the modular and selective Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddtion (..
  97. ncbi Paeoniflorin suppress NF-kappaB activation through modulation of I kappaB alpha and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells
    Hao Wu
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, PR China
    Biomed Pharmacother 62:659-66. 2008
    ..We sought to determine whether paeoniflorin enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells, and, if so, to determine the relationship between this apoptosis and NF-kappaB activation...
  98. ncbi Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells
    Xiaolan Hu
    Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China
    Biochem Biophys Res Commun 398:62-7. 2010
    ..Our results demonstrated for the first time that salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells and may be a promising candidate for breast cancer treatment...
  99. ncbi Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3
    Marisa F Azevedo
    CBMA Centre of Molecular and Environmental Biology Department of Biology, University of Minho, Campus de Gualtar, Braga, Portugal
    Phytother Res 24:S220-4. 2010
    ....
  100. ncbi Deoxynivalenol, deoxynivalenol-3-glucoside, and enniatins: the major mycotoxins found in cereal-based products on the Czech market
    Alexandra Malachova
    Department of Food Chemistry and Analysis, Faculty of Food and Biochemical Technology, Institute of Chemical Technology Prague, Technicka 3, 166 28 Prague 6, Czech Republic
    J Agric Food Chem 59:12990-7. 2011
    ..Enniatin A1 was found only in 44% of samples at levels ranging between 8 and 851 μg/kg...
  101. ncbi Polydatin protects learning and memory impairments in a rat model of vascular dementia
    Run Ping Li
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
    Phytomedicine 19:677-81. 2012
    ..These results suggest that polydatin exhibit therapeutic potential for vascular dementia, which is most likely related, at least in part, to its anti-oxidant activity and the direct protection of neurons...

Research Grants62

  1. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
    ..GTFs): GTFs involved in the biosynthesis of vancomycin group antibiotics, GTFs which create sterol glucosides, and two GTFs involved in the glycosylation of diacylglycerol...
  2. Synthesis and DNA binding affinity evaluation of novel gilvocarcin-C-glucosides
    THOMAS GERARD MINEHAN; Fiscal Year: 2013
    ..Such molecules, if capable of selectively interacting with the promoters or coding regions of target genes, may ultimately be used for the regulation of gene transcription and as therapeutic agents for a wide range of disease states. ..
  3. METHODS FOR AUTOMATED SYNTHESES OF OLIGOSACCHARIDES AND LECTIN TAGS
    Nicola L Pohl; Fiscal Year: 2012
    ..The specific aims of the proposed project are to: 1) develop methods for the automated syntheses of beta-glucosides and one of the most challenging glycosidic linkages-beta-mannosides-and apply these methods to the automated ..
  4. BETA-GLUCOSIDASES IN GAUCHER DISEASE
    Robert Glew; Fiscal Year: 1991
    ..its subcellular location in liver and spleen and because it hydrolyzes a variety of glycosides, including Beta-D-glucosides, Beta-D-galactosides and alpha-L-arabinosides. The function of this second Beta-glucosidase is obscure...
  5. MECHANISM OF DIVICINE TOXICITY
    DAVID MC MILLAN; Fiscal Year: 1999
    ..naturally-occurring environmental chemicals that are found in fava beans (Vicia faba) as the pyrimidine beta- glucosides, vicine and convicine, respectively...
  6. WATER-SOLUBLE PRODRUGS OF TAXOL AGAINST COLON CANCER
    LUKE LAM; Fiscal Year: 1993
    ..Although there are more than 60 derivatives known, taxol beta-glucosides and beta-galactosides are not known...
  7. MECHANISMS OF CHAIN ELONGATION OF ALPHA-KETO ACIDS
    Carl Stevens; Fiscal Year: 1980
    ..a key feature of the biosynthesis of a variety of amino acids which are immediate precursors of the mustard oil glucosides (glucosinolates) occurring in the Cruciferae and other plants...
  8. QUANTITATION & BIOAVAILABILITY OF SOYFOOD ISOFLAVONES
    Patricia Murphy; Fiscal Year: 1992
    ..the amounts of genistin, daidzin, their aglycones, genistein and daidzein, the 6"-0-acetyl forms of the glucosides in an array of soy foods...
  9. ALKYL PHOSPHOCHOLINE AND PHOSPHOETHANOLIMINE DETERGENTS
    MELVIN KEYES; Fiscal Year: 1999
    ..Note that the some of the alkyl phosphocholines synthesized and evaluated were better than the available alkyl glucosides and maltosides. PROPOSED COMMERCIAL APPLICATIONS: Available detergents are not satisfactory in many cases...
  10. Time-lines of neural degeneration in ALS-PDC mouse model
    Christopher A Shaw; Fiscal Year: 2010
    ..questions, adult male CD-1 mice will be fed washed cycad or the isolated putative cycad toxins, variant steryl glucosides. A detailed time-line of behavioral, morphological, and biochemical events will be studied from initial exposure ..
  11. NOVEL DETERGENTS FOR CRYSTALLIZING MEMBRANE PROTEINS
    MELVIN KEYES; Fiscal Year: 1993
    ..In Phase I the applicants synthesized, purified and evaluated a homologous series of novel substituted glucosides and maltosides that have a hydorophobic tail of varying degrees of rigidity...
  12. NOVEL DETERGENTS FOR CRYSTALLIZING MEMBRANE PROTEINS
    MELVIN KEYES; Fiscal Year: 1990
    ..The applicants, therefore, propose to synthesize a homologous series of novel substituted glucosides and maltosides that will be pure, mild (nondenaturing) and have somewhat rigid hydrophobic tails...
  13. Neurotoxicity of sterol glucosides: role in ALS-PDC
    Christopher Shaw; Fiscal Year: 2008
    ..In vitro studies have identified the putative neurotoxins in washed cycad flour as variant forms of sterol glucosides. We hypothesize that sterol glucosides similar to those found in cycad and other plants, or those made by ..
  14. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
  15. HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITY
    JOHN GLENDINNING; Fiscal Year: 2001
    ..A normative data-base for both screens will be established and made available to the scientific community. The assay procedures developed will be applicable by a single laboratory technician with limited experience. ..
  16. Non-Invasive Imaging of T Cell Trafficking
    Bernd Pichler; Fiscal Year: 2006
    ..abstract_text> ..
  17. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2006
    ..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. [unreadable] [unreadable]..
  18. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  19. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  20. Structure & Function of Epididymis and Vas Deferens
    Kenneth Roberts; Fiscal Year: 2007
    ..The proposed studies will provide significant contributions to our understanding of sperm function and may also have potential application to male infertility and contraceptive development. ..
  21. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  23. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Industrial Metabolic Engineering
    J Weber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Structural studies of target recognition by large natural product antibiotics
    Patrick J Loll; Fiscal Year: 2010
    ..This project will provide essential information about naturally occurring antimicrobial compounds. This information will facilitate the rational development of these natural compounds into next generation therapeutic agents. ..
  26. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  27. Free-Living Physical Activity and Energy Expenditure
    Carol Boozer; Fiscal Year: 2003
    ..Finally, data from these studies will provide the basis for a future application to conduct a longitudinal, PA intervention study in this population. ..
  28. High Resolution Cryo-Electron Microscope
    JAMES STOOPS; Fiscal Year: 2002
    ..The identification of seven secondary users shows that there is major interest in the larger medical school community that may greatly benefit by acquisition of the high-resolution electron microscope...
  29. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  30. Automated Protein Crystal Growth in Lipidic Cubic Phase
    PETER NOLLERT VON SPECHT; Fiscal Year: 2002
    ..Emerald BioStructures has employed three crystallographers with membrane protein experience, Craig Behnke, Thomas Richter, and Peter Nollert, one of the developers of LCP technology at UCSF. ..
  31. ASCORBIC ACID GLYCATION AND SENILE CATARACT FORMATION
    BERYL ORTWERTH; Fiscal Year: 2002
    ..abstract_text> ..
  32. LENS INHIBITOR PROTEINS AND CATARACTOGENESIS
    BERYL ORTWERTH; Fiscal Year: 2006
    ....
  33. NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITY
    Gertraud Maskarinec; Fiscal Year: 2002
    ....
  34. MYCOBACTERIAL CELL WALL RECOGNITION BY MACROPHAGES
    Kelly Smith; Fiscal Year: 2002
    ..tuberculosis, and disclose fundamental principles of innate immunity in infectious and inflammatory diseases. ..
  35. Economical Soy Isoflavone Production
    J Weber; Fiscal Year: 2004
    ..This should raise production levels of isoflavones to commercially useful levels. In addition/other bacterial fermentations will be investigated for the production of new biologically active isoflavone metabolites. ..
  36. Synthesis of Various C-Linked Glycopeptides of Biomedical Interest
    ERNEST NOLEN; Fiscal Year: 2008
    ..The prepared materials will be used to better define the structural parameters by which these molecules interact and function, and to develop potential therapeutics or diagnostics for cancer. [unreadable] [unreadable] [unreadable]..
  37. STRUCTURE AND MECHANISM OF PROSTAGLANDIN H2 SYNTHASE
    PATRICK LOLL; Fiscal Year: 2002
    ..Finally, structures of different cyclooxygenase or peroxidase deficient forms of the enzyme will be determined to help clarify the relationship between the two activities. ..
  38. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  39. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  40. Engineering metabolic flow for rapamycin production
    J Weber; Fiscal Year: 2005
    ..This will be the first test of this technology for a drug other than erythromycin, and will help to establish the general applicability of the strategy for strain improvement. ..
  41. Biosynthesis and Function of Base J
    Robert S Sabatini; Fiscal Year: 2010
    ..These studies may prove useful in identifying novel approaches to prevention, treatment and diagnosis of the debilitating and deadly diseases caused by these parasites. ..
  42. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  43. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2001
    ..A 3-D reconstruction of the beef kidney intact PDC will permit a comparison of the mammalian and yeast complexes. ..
  44. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  45. Mapping the Crystallization Slot for Membrane Proteins(R
    PATRICK LOLL; Fiscal Year: 2006
    ..High resolution structural information is absolutely required for any in-depth understanding of the basic functioning of these molecules, as well as for the discovery and development of new therapeutic agents. ..
  46. ALPHA AND BETA CELL FUNCTION IN NORMAL AND DIABETIC MAN
    John Gerich; Fiscal Year: 2007
    ..Further knowledge of the control of renal glucose release could therefore have therapeutic implications for this disorder and in people with liver and kidney disease. [unreadable] [unreadable]..
  47. Crystallization of Ataxin-3
    PATRICK LOLL; Fiscal Year: 2005
    ..The molecular understanding of ataxin-3 that will be obtained from this work is a prerequisite for any rational design of therapeutics that will interfere with the protein's aberrant folding and aggregation. ..
  48. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  49. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2003
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  50. Antibiotic Gene Clusters
    J Weber; Fiscal Year: 2005
    ..In Phase II we are proposing to apply this new basic knowledge to the development of modern methods of strain improvement for erythromycin and other important drugs. ..
  51. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  52. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  53. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  54. Identification of Anti-Viral Compounds from Plants
    Shiyou Li; Fiscal Year: 2005
    ..abstract_text> ..
  55. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  56. Novel Macrolide and Ketolide Antibiotic Intermediates
    J Weber; Fiscal Year: 2003
    ..In addition, a new macrolide biosynthetic gene cluster will be cloned and its gene sequenced obtained in part, to identify new biotailoring enzymes for future work in Phase II. ..
  57. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2002
    ..A 3-D reconstruction of the beef kidney intact PDC will permit a comparison of the mammalian and yeast complexes. ..
  58. An Integrated PET-MRI System for Molecular Imaging
    Bernd Pichler; Fiscal Year: 2005
    ..abstract_text> ..
  59. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  60. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  61. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  62. Imaging and Laser Revascularization in Hibernation
    Lynne Johnson; Fiscal Year: 2003
    ....