Genomes and Genes
Summary: An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Publications273 found, 100 shown here
- Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and hostManja Barthel
Institute of Microbiology, ETH Zurich, 8092 Zurich, Switzerland
Infect Immun 71:2839-58. 2003..We describe here how streptomycin-pretreated mice provide a mouse model for serovar Typhimurium colitis...
- Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350Yasuo Ohnishi
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
J Bacteriol 190:4050-60. 2008..genome sequence of Streptomyces griseus IFO 13350, a soil bacterium producing an antituberculosis agent, streptomycin, which is the first aminoglycoside antibiotic, discovered more than 60 years ago...
- Antimicrobial treatment for early, limited Mycobacterium ulcerans infection: a randomised controlled trialWillemien A Nienhuis
Department of Internal Medicine, University Medical Centre Groningen, University of Groningen, Netherlands
Lancet 375:664-72. 2010..ulcer disease) until WHO issued provisional guidelines in 2004 recommending treatment with antimicrobial drugs (streptomycin and rifampicin) in addition to surgery...
- Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated miceSiegfried Hapfelmeier
Institute of Microbiology, ETH Zurich, CH 8092 Zurich, Switzerland
Infect Immun 72:795-809. 2004..We recently found that orally streptomycin-pretreated mice provide an alternative model for serovar Typhimurium colitis...
- Clinical efficacy of combination of rifampin and streptomycin for treatment of Mycobacterium ulcerans diseaseFred Stephen Sarfo
Komfo Anokye Teaching Hospital, Kumasi, Ghana
Antimicrob Agents Chemother 54:3678-85. 2010..the clinical efficacy of the combination of oral rifampin at 10 mg/kg of body weight and intramuscular streptomycin at 15 mg/kg for 8 weeks (RS8), as recommended by the WHO, in 160 PCR-confirmed cases of Mycobacterium ulcerans ..
- The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune responsePatrick Kaiser
Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
Immunol Rev 245:56-83. 2012..To study these mechanisms, the streptomycin mouse model for Salmonella diarrhea is of great value. Here, we review how S...
- Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli Ulcer (Mycobacterium ulcerans disease)Kapay Kibadi
Programme National de Lutte contre l Ulcère de Buruli, Kinshasa, Democratic Republic of the Congo
PLoS Negl Trop Dis 4:e736. 2010..ulcerans disease, also called "Buruli ulcer" (BU), with a combination of the antibiotics rifampicin and streptomycin (R+S), whether followed by surgery or not. In endemic areas, a clinical case definition is recommended...
- The Vibrio parahaemolyticus ToxRS regulator is required for stress tolerance and colonization in a novel orogastric streptomycin-induced adult murine modelW Brian Whitaker
Department of Biological Sciences, University of Delaware, Newark, Delaware, USA
Infect Immun 80:1834-45. 2012..We demonstrated that streptomycin-treated adult C57BL/6 mice experienced prolonged intestinal colonization along the entire intestinal tract by ..
- Treating Mycobacterium ulcerans disease (Buruli ulcer): from surgery to antibiotics, is the pill mightier than the knife?Paul J Converse
Johns Hopkins University Center for Tuberculosis Research, 1551 Jefferson Street, 154, Baltimore, MD 21287, USA
Future Microbiol 6:1185-98. 2011..on promising preclinical studies, treatment trials in West Africa have shown that a combination of rifampin and streptomycin administered daily for 8 weeks can kill M...
- Influence of soil use on prevalence of tetracycline, streptomycin, and erythromycin resistance and associated resistance genesMagdalena Popowska
Department of Applied Microbiology, Institute of Microbiology, University of Warsaw, Warsaw, Poland
Antimicrob Agents Chemother 56:1434-43. 2012..from agricultural systems that were amended with manure from animals treated with erythromycin and exposed to streptomycin and/or oxytetracycline, as well as non-manure-amended compost and forest soil...
- Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimuriumSophie Maisnier-Patin
Department of Bacteriology, Swedish Insitute for Infectious Disease Control, Solna, Sweden
Mol Microbiol 46:355-66. 2002..In Salmonella typhimurium, the nucleotide substitution AAA42 --> AAC in the rpsL gene confers resistance to streptomycin. The resulting amino acid substitution (K42N) in ribosomal protein S12 causes an increased rate of ribosomal ..
- Local and regional re-establishment of cellular immunity during curative antibiotherapy of murine Mycobacterium ulcerans infectionTeresa G Martins
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
PLoS ONE 7:e32740. 2012..Since 2004, the World Health Organization recommends the treatment of BU with a combination of rifampicin and streptomycin (RS)...
- Chicken faecal microbiota and disturbances induced by single or repeated therapy with tetracycline and streptomycinPetra Videnska
Veterinary Research Institute, Hudcova 70, 621 00, Brno, Czech Republic
BMC Vet Res 9:30. 2013..the microbiota present in the faeces of 15- and 46-week-old egg laying hens before and after tetracycline or streptomycin therapy. In the first experiment, the layers were subjected to 7 days of therapy...
- Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated miceBärbel Stecher
Institute of Microbiology, ETH Zurich, Schmelzbergstrasse 7, 8092 Zurich, Switzerland
Infect Immun 72:4138-50. 2004..b>Streptomycin-pretreated mice provide an alternative animal model to study enteric salmonellosis...
- Promising clinical efficacy of streptomycin-rifampin combination for treatment of buruli ulcer (Mycobacterium ulcerans disease)Annick Chauty
Centrr de Dépistage et de Traitement de l ulcère de Buruli, Pobè, Benin
Antimicrob Agents Chemother 51:4029-35. 2007..6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobè, Bénin...
- The high level streptomycin resistance gene from Streptococcus pneumoniae is a homologue of the ribosomal protein S12 gene from Escherichia coliC Salles
CNRS UPR9007, Universite Paul Sabatier, Toulouse, France
Nucleic Acids Res 20:6103. 1992
- In vitro and in vivo activities of rifampin, streptomycin, amikacin, moxifloxacin, R207910, linezolid, and PA-824 against Mycobacterium ulceransBaohong Ji
Bactériologie Hygiène, Faculte de Medecine Pierre et Marie Curie, Universite Paris 6, France
Antimicrob Agents Chemother 50:1921-6. 2006..R207910 demonstrated the lowest MIC(50) and MIC(90), followed by moxifloxacin (MXF), streptomycin (STR), rifampin (RIF), amikacin (AMK), linezolid (LZD), and PA-824...
- Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosomeDivya Sharma
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Mol Biol 374:1065-76. 2007..The aminoglycosides paromomycin and streptomycin bind to the decoding center and induce related structural rearrangements that explain their observed effects on ..
- Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolismDagmara K Derewacz
Department of Chemistry, Vanderbilt University, Nashville, TN 37204, USA
Proc Natl Acad Sci U S A 110:2336-41. 2013..of ultra-performance liquid chromatography-ion mobility-mass spectrometry metabolomic features from a cohort of streptomycin- and rifampicin-resistant mutants grown in the absence of antibiotics exhibits clear metabolomic speciation, ..
- Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infectionTianyu Zhang
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Antimicrob Agents Chemother 55:56-61. 2011..Only recently was antimicrobial therapy proven effective. Treatment for 2 months with rifampin plus streptomycin was first proposed after experiments in the mouse footpad model demonstrated bactericidal activity...
- Chemotherapy-associated changes of histopathological features of Mycobacterium ulcerans lesions in a Buruli ulcer mouse modelMarie Therese Ruf
Swiss Tropical and Public Health Institute, Basel, Switzerland
Antimicrob Agents Chemother 56:687-96. 2012Combination chemotherapy with rifampin and streptomycin (RIF-STR) for 8 weeks is currently recommended by the WHO as the first-line treatment for Mycobacterium ulcerans infection (Buruli ulcer)...
- Streptomycin-resistant (rpsL) or rifampicin-resistant (rpoB) mutation in Pseudomonas putida KH146-2 confers enhanced tolerance to organic chemicalsKeiichi Hosokawa
National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
Environ Microbiol 4:703-12. 2002We found that certain Str-, Gen- or Rif- mutants derived from Pseudomonas putida KH146-2, which are resistant to streptomycin, gentamicin or rifampicin, respectively, are tolerant to the aromatic compound 4-hydroxybenzoate (4HBA)...
- The genetic background for streptomycin resistance in Escherichia coli influences the distribution of MICsMarianne Sunde
Section of Bacteriology and Norwegian Zoonosis Centre, National Veterinary Institute, Oslo
J Antimicrob Chemother 56:87-90. 2005The aim of this study was to investigate the genetic background for streptomycin resistance in Escherichia coli and perform analysis of the MICs in relation to genetic background.
- Effects of Escherichia coli ribosomal protein S12 mutations on cell-free protein synthesisNamthip Chumpolkulwong
RIKEN Genomic Sciences Center, Tsurumi, Yokohama, Japan
Eur J Biochem 271:1127-34. 2004..By screening 150 spontaneous streptomycin-resistant isolates from E...
- The streptomycin-treated mouse intestine selects Escherichia coli envZ missense mutants that interact with dense and diverse intestinal microbiotaMary P Leatham-Jensen
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, USA
Infect Immun 80:1716-27. 2012Previously, we reported that the streptomycin-treated mouse intestine selected nonmotile Escherichia coli MG1655 flhDC deletion mutants of E...
- Glycogen and maltose utilization by Escherichia coli O157:H7 in the mouse intestineShari A Jones
Advanced Center for Genome Technology, University of Oklahoma, Norman, Oklahoma 73019, USA
Infect Immun 76:2531-40. 2008..By using the streptomycin-treated mouse model, we found that catabolism of the disaccharide maltose provides a competitive advantage in ..
- rrs and rpsL mutations in streptomycin-resistant isolates of Mycobacterium tuberculosis from MexicoBetzaida Cuevas-Córdoba
Laboratorio de Ecología y Salud, Instituto de Salud Pública, Universidad Veracruzana, Veracruz, Mexico
J Microbiol Immunol Infect 46:30-4. 2013Mutations in rpsL and rrs genes are associated with resistance to streptomycin in tuberculosis, but important geographical variation exists in these mutations...
- Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosisMing Zhang
Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Antimicrob Agents Chemother 56:5782-9. 2012Mycobacterium tuberculosis 18b, a streptomycin (STR)-dependent mutant that enters a viable but nonreplicating state in the absence of STR, has been developed as a simple model for drug testing against dormant bacilli...
- Combining PCR with microscopy to reduce costs of laboratory diagnosis of Buruli ulcerDorothy Yeboah-Manu
Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
Am J Trop Med Hyg 85:900-4. 2011..This stepwise approach reduced unit cost by more than 50% to $5.41, and the total costs were reduced from $917 to $433...
- Acute brucellosis: presentation, diagnosis, and treatment of 144 casesPanos Andriopoulos
Gytheio Health Care Centre, Gytheio Lakonia 23200, Greece
Int J Infect Dis 11:52-7. 2007..Presented herein is our 14-year experience with acute brucellosis at Sparta General Hospital, Lakonia, Greece...
- Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)J Shima
National Food Research Institute, Tsukuba, Ibaraki, Japan
J Bacteriol 178:7276-84. 1996..lividans normally does not produce this antibiotic. Genetic analyses revealed that a streptomycin-resistant mutation str-6 in strain TK24 is responsible for induction of antibiotic synthesis...
- Analysis of rpsL and rrs mutations in Beijing and non-Beijing streptomycin-resistant Mycobacterium tuberculosis isolates from SingaporeY J Sun
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore City, Republic of Singapore
Clin Microbiol Infect 16:287-9. 2010..1%) of alterations in streptomycin-resistant M...
- Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosisGuntram A Grassl
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
Gastroenterology 134:768-80. 2008..Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis...
- Mutations in gidB confer low-level streptomycin resistance in Mycobacterium tuberculosisSharon Y Wong
Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Antimicrob Agents Chemother 55:2515-22. 2011..for resistance to one of the oldest and most widely used second-line drugs employed in tuberculosis therapy, streptomycin (SM)...
- Secondary Buruli ulcer skin lesions emerging several months after completion of chemotherapy: paradoxical reaction or evidence for immune protection?Marie Therese Ruf
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 5:e1252. 2011..After the recommended eight weeks standard treatment with rifampicin and streptomycin, a reversal of the local immunosuppression caused by the macrolide toxin mycolactone of M. ulcerans is observed.
- Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteriaSusumu Okamoto
Microbial Function Laboratory, National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki, Japan
Mol Microbiol 63:1096-106. 2007b>Streptomycin has been an important drug for the treatment of tuberculosis since its discovery in 1944. But numerous strains of Mycobacterium tuberculosis, the bacterial pathogen that causes tuberculosis, are now streptomycin resistant...
- Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouseElla W Yeung
School of Medical Sciences and Institute for Biomedical Research, University of Sydney F13, NSW 2006, Australia
J Physiol 562:367-80. 2005..Two blockers of stretch-activated channels, streptomycin and the spider venom toxin GsMTx4, prevented the rise of resting [Ca(2+)](i) and partially prevented the ..
- Prevalence of tuberculosis drug resistance in 10 provinces of ChinaGuang Xue He
National Center for TB control and prevention, China Center for Disease Control and Prevention CDC, Beijing, PR China
BMC Infect Dis 8:166. 2008..The emergence of drug-resistant tuberculosis (TB) hampers TB control. Ten provinces in China performed drug resistance surveys among tuberculosis (TB) patients in 1996-2004 to assess levels of drug resistance...
- The fitness cost of streptomycin resistance depends on rpsL mutation, carbon source and RpoS (sigmaS)Wilhelm Paulander
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Genetics 183:539-46, 1SI-2SI. 2009..The streptomycin resistance (StrR) mutations K42N and P90S in ribosomal protein S12 impair growth on rich medium...
- Distribution of tetracycline and streptomycin resistance genes and class 1 integrons in Enterobacteriaceae isolated from dairy and nondairy farm soilsVelusamy Srinivasan
Department of Animal Science and the Food Safety Center of Excellence, The University of Tennessee, Knoxville, TN 37996, USA
Microb Ecol 55:184-93. 2008The prevalence of selected tetracycline and streptomycin resistance genes and class 1 integrons in Enterobacteriaceae (n = 80) isolated from dairy farm soil and nondairy soils was evaluated...
- Streptomycin inhibits quorum sensing in Acinetobacter baumanniiSunil D Saroj
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
Antimicrob Agents Chemother 57:1926-9. 2013b>Streptomycin at subinhibitory concentrations was found to inhibit quorum sensing in Acinetobacter baumannii. Conditioned medium prepared by growth of A...
- Corticosteroid-induced immunosuppression ultimately does not compromise the efficacy of antibiotherapy in murine Mycobacterium ulcerans infectionTeresa G Martins
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
PLoS Negl Trop Dis 6:e1925. 2012..It has been suggested that the immune response developed during the recommended rifampicin/streptomycin (RS) antibiotherapy is protective, contributing to bacterial clearance...
- Increased transmission of Mycobacterium tuberculosis Beijing genotype strains associated with resistance to streptomycin: a population-based studyTran N Buu
Tuberculosis Control Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam
PLoS ONE 7:e42323. 2012..This suggests that drug resistant Beijing strains have a relatively high transmission fitness compared to other drug-resistant strains...
- Association of streptomycin resistance mutations with level of drug resistance and Mycobacterium tuberculosis genotypesN T Q Nhu
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Int J Tuberc Lung Dis 16:527-31. 2012To determine 1) the relationship between specific streptomycin (SM) resistance mutations and the minimum inhibitory concentration (MIC), and 2) whether these mutations are preferentially associated with the Beijing genotype in Viet Nam.
- Development of highly organized lymphoid structures in Buruli ulcer lesions after treatment with rifampicin and streptomycinDaniela Schütte
Swiss Tropical Institute, Molecular Immunology, Basel, Switzerland
PLoS Negl Trop Dis 1:e2. 2007..While traditionally wide excision of the infected tissue was the standard treatment, provisional WHO guidelines now recommend an eight week pre-treatment with streptomycin and rifampicin.
- Fitness cost of chromosomal drug resistance-conferring mutationsPeter Sander
Institut fur Medizinische Mikrobiologie, Universitat Zurich, CH 8028 Zurich, Switzerland
Antimicrob Agents Chemother 46:1204-11. 2002..These results argue against expectations that link decreased levels of antibiotic consumption with the decline in the level of resistance...
- Establishing streptomycin epidemiological cut-off values for Salmonella and Escherichia coliLourdes Garcia-Migura
National Food Institute, Technical University of Denmark, Lyngby, Denmark
Microb Drug Resist 18:88-93. 2012This study was conducted to elucidate the accuracy of the current streptomycin epidemiological cut-off value (ECOFF) for Escherichia coli and Salmonella spp. A total of 236 Salmonella enterica and 208 E...
- Streptomycin resistance and lineage-specific polymorphisms in Mycobacterium tuberculosis gidB geneFernanda S Spies
Programa de Pos Graduacao em Genetica e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Clin Microbiol 49:2625-30. 2011Mutations related to streptomycin resistance in the rpsL and rrs genes are well known and can explain about 70% of this phenotypic resistance...
- Contraselectable streptomycin susceptibility determinant for genetic manipulation and analysis of Helicobacter pyloriDaiva Dailidiene
Department of Molecular Microbiology, Campus Box 8230, Washington University Medical School, 4940 Parkview Place, St Louis, MO 63110, USA
Appl Environ Microbiol 72:5908-14. 2006..is a two-gene cassette that can be selected both (i) against, due to a Campylobacter jejuni rpsL gene (dominant streptomycin susceptibility in cells also carrying an rpsL-str(r) allele), and (ii) for, due to an erm gene (erythromycin ..
- Spread of extensively drug-resistant tuberculosis in KwaZulu-Natal province, South AfricaPrashini Moodley
KwaZulu Natal Research Institute for Tuberculosis and HIV K RITH, Durban, South Africa
PLoS ONE 6:e17513. 2011..KZN is divided into 11 healthcare districts. We sought to determine the distribution of XDR TB cases in the province in relation to population density...
- Plasmid-mediated streptomycin and sulfamethoxazole resistance in Shigella flexneri 3aSoumik Barman
Division of Bacteriology, National Institute of Cholera and Enteric Diseases, P 33 CIT Road, Scheme XM, Beliaghata, Kolkata 700 010, India
Int J Antimicrob Agents 36:348-51. 2010..was resistant to ampicillin, chloramphenicol, co-trimoxazole (trimethoprim/sulfamethoxazole), nalidixic acid, streptomycin, sulfamethoxazole, tetracycline and trimethoprim. However, it was susceptible to 46.7% of drugs tested, i.e...
- Characterization of mutations in streptomycin-resistant Mycobacterium tuberculosis clinical isolates in the area of BarcelonaGriselda Tudó
Servei de Microbiologia, CDB, Hospital Clínic de Barcelona IDIBAPS, Universitat de Barcelona UB, Barcelona, Spain
J Antimicrob Chemother 65:2341-6. 2010To determine the proportion and type of mutations in Mycobacterium tuberculosis isolates resistant to streptomycin, and their relationship with the level of resistance and with the epidemiological molecular pattern of the isolates.
- Global gene expression profile of Yersinia pestis induced by streptomycinJingfu Qiu
Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences AMMS, Beijing 100071, China
FEMS Microbiol Lett 243:489-96. 2005..Cases of plague can be normally controlled by timely antibiotic administration. Streptomycin is the first-line antibiotic for plague treatment...
- Orally administered combined regimens for treatment of Mycobacterium ulcerans infection in miceBaohong Ji
Bactériologie Hygiène, Faculte de Medecine Pierre et Marie Curie, Universite Paris 6, 91 Boulevard de l Hopital, 75634, Paris Cedex 13, France
Antimicrob Agents Chemother 51:3737-9. 2007Eight weeks of treatment with rifampin-streptomycin sterilizes Mycobacterium ulcerans infection in mice. Because the bactericidal activity against M...
- Severe multifocal form of buruli ulcer after streptomycin and rifampin treatment: comments on possible dissemination mechanismsGhislain Emmanuel Sopoh
Centre de Dépistage et de Traitement de l Ulcère de Buruli d Allada, Benin
Am J Trop Med Hyg 83:307-13. 2010..The advent of antibiotic treatment with streptomycin (S) and rifampin (R) raised hope that these multifocal BU cases could be reduced...
- Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in MichiganGayle C McGhee
Department of Plant Pathology, Michigan State University, East Lansing, MI, USA
Phytopathology 101:182-91. 2011b>Streptomycin-resistant (Sm(R)) strains of the fire blight pathogen Erwinia amylovora were first isolated in southwest Michigan in 1991...
- Role of helix 44 of 16S rRNA in the fidelity of translation initiationDaoming Qin
Department of Microbiology, Ohio State Biochemistry Program, and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
RNA 18:485-95. 2012..Second, mutations in h44 such as A1413C stimulate 50S docking and cause reduced reactivity at A1408. Third, streptomycin, which has been shown by Rodnina and coworkers to stimulate 50S docking by reversing the inhibitory effects of ..
- Phylogeny of Streptomyces species and evidence for horizontal transfer of entire and partial antibiotic gene clustersS Egan
Department of Biological Sciences, University of Warwick, Coventry, UK
Antonie Van Leeuwenhoek 79:127-33. 2001..One strain had acquired the entire streptomycin biosynthetic cluster, whilst the other contained only strRAB1, the resistance gene and two flanking genes from ..
- Mistranslation induced by streptomycin provokes a RecABC/RuvABC-dependent mutator phenotype in Escherichia coli cellsSergey Balashov
Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Mol Biol 315:513-27. 2002..TSM response is mediated by non-specific mistranslation rather than specific Asp-->Gly misreading, we asked if streptomycin (Str), an aminoglycoside antibiotic known to promote mistranslation, can provoke a mutator phenotype...
- Histopathological changes and clinical responses of Buruli ulcer plaque lesions during chemotherapy: a role for surgical removal of necrotic tissue?Marie Therese Ruf
Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 5:e1334. 2011..During the currently recommended antibiotic treatment with rifampicin/streptomycin plaque lesions tend to ulcerate, often associated with retarded wound healing and prolonged hospital stays.
- Distinct recent lineages of the strA- strB streptomycin-resistance genes in clinical and environmental bacteriaGeorge W Sundin
Department of Plant Pathology and Microbiology, Texas A and M University, 2132 TAMU, College Station, TX 77843 2132, USA
Curr Microbiol 45:63-9. 2002We report the linkage of the strA-strB streptomycin-resistance genes with Class 1 integron sequences on pSTR1, a 75-kb multiple antibiotic-resistance plasmid from Shigella flexneri...
- Effects of production of abnormal proteins on the rate of killing of Escherichia coli by streptomycinM A Wyka
Department of Biological Sciences, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey 08855 1059
Antimicrob Agents Chemother 34:534-8. 1990The role of abnormal membrane proteins in modulating the rate of killing by streptomycin was investigated. Davis et al. (B.D. Davis, L. Chen, and P.T. Tai, Proc. Natl. Acad. Sci...
- Evaluation of kasugamycin for fire blight management, effect on nontarget bacteria, and assessment of kasugamycin resistance potential in Erwinia amylovoraGayle C McGhee
Department of Plant Pathology, Michigan State University, East Lansing, MI, USA
Phytopathology 101:192-204. 2011The emergence and spread of streptomycin-resistant strains of Erwinia amylovora in Michigan has necessitated the evaluation of new compounds effective for fire blight control...
- The bactericidal action of streptomycin: membrane permeabilization caused by the insertion of mistranslated proteins into the cytoplasmic membrane of Escherichia coli and subsequent caging of the antibiotic inside the cells due to degradation of these proH J Busse
Universitat Osnabruck, Fachgebiet Mikrobiologie, FRG
J Gen Microbiol 138:551-61. 1992The mechanism by which the aminoglycoside antibiotic streptomycin permeabilizes the cytoplasmic membrane of Escherichia coli cells was reinvestigated...
- Plant agricultural streptomycin formulations do not carry antibiotic resistance genesFabio Rezzonico
Agroscope Changins Wadenswil, ACW, Swiss National Competence Center for Fire Blight, Wädenswil, Switzerland
Antimicrob Agents Chemother 53:3173-7. 2009b>Streptomycin is used in plant agriculture for bacterial disease control, particularly against fire blight in pome fruit orchards. Concerns that this may increase environmental antibiotic resistance have led to bans or restrictions on use...
- Comparative evaluation of the nitrate reduction assay, the MTT test, and the resazurin microtitre assay for drug susceptibility testing of clinical isolates of Mycobacterium tuberculosisErnesto Montoro
Laboratorio Nacional de Referencia e Investigaciones en Tuberculosis y Mycobacteria, Instituto de Medicina Tropical Pedro Kouri, Havana, Cuba
J Antimicrob Chemother 55:500-5. 2005..To evaluate the performance of three rapid low-cost methods for the detection of resistance to first-line drugs in Mycobacterium tuberculosis...
- Tuberculosis: drug resistance, fitness, and strategies for global controlErik C Bottger
Nationales Zentrum für Mykobakterien, Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, 8006, Zurich, Switzerland
Eur J Pediatr 167:141-8. 2008..g. isoniazid, rifampicin, streptomycin, may or may not be associated with a fitness cost...
- Virulence of broad- and narrow-host-range Salmonella enterica serovars in the streptomycin-pretreated mouse modelMrutyunjay Suar
Institute of Microbiology, Department of Biology, ETH Honggerberg, Wolfgang Pauli Str 10, 8093, Zurich, Switzerland
Infect Immun 74:632-44. 2006..enterica serovar are unknown. Streptomycin pretreated mice provide a surrogate host model for studying molecular aspects of the intestinal inflammation (..
- Precolonized human commensal Escherichia coli strains serve as a barrier to E. coli O157:H7 growth in the streptomycin-treated mouse intestineMary P Leatham
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island 02881, USA
Infect Immun 77:2876-86. 2009..have the same metabolic capacity for growth on sugars in vitro, but they appear to use different sugars in the streptomycin-treated mouse intestine (Fabich et al., Infect. Immun. 76:1143-1152, 2008)...
- Tularemia, a reemerging disease in northwest Turkey: epidemiological investigation and evaluation of treatment responsesGuven Celebi
Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak, Turkey
Jpn J Infect Dis 59:229-34. 2006..Late initiation antibiotic therapy could not prevent suppuration and draining of the involved lymph nodes...
- Phagocytosis of Mycobacterium ulcerans in the course of rifampicin and streptomycin chemotherapy in Buruli ulcer lesionsD Schutte
Swiss Tropical Institute, Molecular Immunology, Socinstr 57, 4051 Basel, Switzerland
Br J Dermatol 160:273-83. 2009Infection with Mycobacterium ulcerans involves a devastating skin disease called Buruli ulcer (BU). Currently, dual therapy with rifampicin and streptomycin (R/S) for 8 weeks as well as surgery are the standard treatments.
- Antibiotic use in plant agriculturePatricia S McManus
Department of Plant Pathology, University of Wisconsin, Madison 53706 1598, USA
Annu Rev Phytopathol 40:443-65. 2002..Today, the antibiotics most commonly used on plants are oxytetracycline and streptomycin. In the USA, antibiotics applied to plants account for less than 0.5% of total antibiotic use...
- The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamilyPaul G Young
School of Biological Sciences, University of Auckland, Auckland, New Zealand
J Bacteriol 191:4133-43. 2009..complex and a ternary complex containing adenosine-5'-(beta,gamma-methylene)triphosphate (AMPPCP) and streptomycin. This is the first crystal structure of a member of the APH(2'') family of aminoglycoside phosphotransferases...
- The cost of multiple drug resistance in Pseudomonas aeruginosaH Ward
Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
J Evol Biol 22:997-1003. 2009..in the context of the evolution of multiple drug resistance (MDR), by measuring the cost of acquiring streptomycin resistance mutations (StrepR) in independent strains of the bacterium Pseudomonas aeruginosa carrying different ..
- Brucellar spondylitis: review of 35 cases and literature surveyJ Solera
Department of Internal Medicine, Hospital General de Albacete, 02006 Albacete, Spain
Clin Infect Dis 29:1440-9. 1999..There were no deaths or severe sequelae in this study. Brucellar spondylitis causes considerable suffering and absenteeism from work, but long-term clinical responses are favorable...
- Tetracycline and streptomycin resistance genes, transposons, and plasmids in Salmonella enterica isolates from animals in ItalyCristina Pezzella
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, Italy
Antimicrob Agents Chemother 48:903-8. 2004..isolated from animal sources in Italy, were analyzed for tet(A) and strA-strB, conferring tetracycline and streptomycin resistance, respectively...
- Curing Mycobacterium ulcerans infection in mice with a combination of rifampin-streptomycin or rifampin-amikacinSébastien Lefrançois
Laboratoire de Bacteriologie Hygiene, Faculte de Medecine Pierre et Marie Curie, Universite Paris 6, and CNRM et de la Résistance aux Antituberculeux, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hôpital de Paris, France
Antimicrob Agents Chemother 51:645-50. 2007The curing activities of various durations of treatment with a combination of rifampin (RIF) and either streptomycin (STR) or amikacin (AMK) in murine Mycobacterium ulcerans infection were compared in two experiments...
- Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humansS Etuaful
St George s Hospital Medical School, Department of Cellular and Molecular Medicine, Cranmer Terrace, London SW17 0RE, United Kingdom
Antimicrob Agents Chemother 49:3182-6. 2005..Lesions were excised either immediately or after treatment with rifampin orally at 10 mg/kg of body weight and streptomycin intramuscularly at 15 mg/kg of body weight daily for 2, 4, 8, or 12 weeks and examined by quantitative ..
- Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteriaY Hosoya
National Food Research Institute, Fujisawa Pharmaceutical Co, Tsukuba, Ibaraki, Japan
Antimicrob Agents Chemother 42:2041-7. 1998..We have found that the acquisition of certain streptomycin-resistant (str) mutations enables cells to overproduce antibiotics, demonstrating an increase in productivity 5-..
- Drug-susceptibility patterns of Mycobacterium tuberculosis in Mpumalanga province, South Africa: possible guiding design of retreatment regimenE Green
AIDS Virus Research Laboratory, Department of Microbiology, University of Venda, South Africa
J Health Popul Nutr 28:7-13. 2010..from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs...
- Molecular characterisation of streptomycin-resistant Mycobacterium tuberculosis strains isolated in PolandA Brzostek
Centre for Medical Biology, Polish Academy of Sciences, Lodz, Poland
Int J Tuberc Lung Dis 8:1032-5. 2004..Among 3705 drug-resistant strains investigated in 2000, 169 were resistant to streptomycin alone or in combination with isoniazid, rifampicin and/or ethambutol...
- Streptomycin resistance in mycobacteriaN Honore
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
Antimicrob Agents Chemother 38:238-42. 1994b>Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level...
- Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycinM O'CONNOR
Section of Biochemistry, Brown University, Providence, RI 02912
Biochimie 73:1493-500. 1991..The effects of the double-mutant constructs have been measured by growth rate, paromomycin and streptomycin sensitivity, resistance and dependence...
- Expression of the strA-strB streptomycin resistance genes in Pseudomonas syringae and Xanthomonas campestris and characterization of IS6100 in X. campestrisG W Sundin
Department of Plant Pathology, Oklahoma State University, Stillwater 74078, USA
Appl Environ Microbiol 61:2891-7. 1995Expression of the strA-strB streptomycin resistance (SMr) genes was examined in Pseudomonas syringae pv. syringae and Xanthomonas campestris pv. vesicatoria. The strA-strB genes in P. syringae and X...
- Isolation of specific RNA-binding proteins using the streptomycin-binding RNA aptamerNikolai Windbichler
Imperial College London, Department of Biological Sciences, Imperial College Road, London SW7 2AZ, UK
Nat Protoc 1:637-40. 2006..The streptomycin-binding aptamer, termed 'StreptoTag,' is embedded in or fused to either end of any RNA of interest...
- Stretch-activated channels in the heart: contributions to length-dependence and to cardiomyopathyMarie Louise Ward
Department of Physiology, Faculty of Medicine and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Prog Biophys Mol Biol 97:232-49. 2008..non-selective cation channels (SAC NSC) reduced the magnitude of the SFR 60s after stretch (400 microM streptomycin: from 86+/-25% to 38+/-14%, P<0.01, n=9; 10 microM GdCl3: from 65+/-21%, to 12+/-7%, P<0...
- [Susceptibility testing of Mycobacterium tuberculosis isolates to primary antituberculous drugs on chocolate agar: a preliminary study]Ahmet Yilmaz Coban
Ondokuz Mayis Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Samsun
Mikrobiyol Bul 42:477-81. 2008..for the susceptibility testing of Mycobacterium tuberculosis strains against isoniazid (INH), rifampicin (RIF), streptomycin (STR) and ethambutol (ETM)...
- Effect of edaravone on streptomycin-induced vestibulotoxicity in the Guinea pigOsamu Horiike
Department of Otolaryngology, Yamaguchi University School of Medicine, Yamaguchi, Japan
Laryngoscope 114:1630-2. 2004The effect of topical administration of edaravone to the inner ear was investigated in guinea pigs with streptomycin-induced vestibulotoxicity.
- Characterisation of rpsL, rrs and embB mutations associated with streptomycin and ethambutol resistance in Mycobacterium tuberculosisTatjana Tracevska
Laboratory of Molecular Microbiology, Biomedical Research and Study Centre, University of Latvia, Ratsupites 1, Riga LV 1067, Latvia
Res Microbiol 155:830-4. 2004..They were all resistant to rifampin (RIF), isoniazid (INH) and streptomycin (SM), and 33 were resistant to ethambutol (EMB)...
- Doxycycline plus streptomycin versus ciprofloxacin plus rifampicin in spinal brucellosis [ISRCTN31053647]Emine Alp
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
BMC Infect Dis 6:72. 2006..The aim of this study is to compare the efficacy, adverse drug reactions, complications and cost of ciprofloxacin plus rifampicin versus doxycycline plus streptomycin in the treatment of spinal brucellosis.
- Multidrug-resistant tuberculosis (TB) resistant to fluoroquinolones and streptomycin but susceptible to second-line injection therapy has a better prognosis than extensively drug-resistant TBEdward D Chan
Department of Medicine, National Jewish Health, Denver, CO 80206, USA
Clin Infect Dis 48:e50-2. 2009Multidrug-resistant tuberculosis (TB) strains resistant to the fluoroquinolones and streptomycin but susceptible to second-line injection treatment would not be defined as extensively drug-resistant TB...
- Cross-resistance of Mycobacterium tuberculosis isolates among streptomycin, kanamycin and amikacinI Sugawara
Mycobacterial Reference Center, The Research Institute of Tuberculosis, 3 1 24 Matsuyama, Kiyose, Tokyo 204 0022, Japan
Indian J Exp Biol 47:520-2. 2009Seventy-four streptomycin (SM)-resistant M. tuberculosis clinical isolates were subjected to cross-resistance drug testing against two major aminoglycosides, kanamycin (KM) and amikacin (AMK). Among them, 15 clinical isolates (20...
- Brucellosis in the middle East: a persistent medical, socioeconomic and political issueG Pappas
Institute for Continuing Medical Education of Ioannina, Greece
J Chemother 19:243-8. 2007..Overall, attempts at controlling disease without altering the socioeconomic and political correlations may prove futile, unfortunately projecting similar fates for attempts related to more important communicable diseases...
- Comparison of the efficacy of gentamicin for 5 days plus doxycycline for 8 weeks versus streptomycin for 2 weeks plus doxycycline for 45 days in the treatment of human brucellosis: a randomized clinical trialM R Hasanjani Roushan
Infectious Diseases Research Center, Babol Medical University, Babol, Iran
J Antimicrob Chemother 65:1028-35. 2010To compare the efficacy of gentamicin for 5 days plus doxycycline for 8 weeks with streptomycin for 2 weeks plus doxycycline for 45 days in the treatment of human brucellosis.
- Streptomycin and chloramphenicol resistance genes in Escherichia coli isolates from cattle, pigs, and chicken in KenyaG M Kikuvi
Institute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
Microb Drug Resist 13:62-8. 2007The aims of this study were to determine the genetic basis of streptomycin and chloramphenicol resistance in 30 Escherichia coli isolates from food animals in Kenya and the role of plasmids in the spread of the resistance...
- Analysis of streptomycin-resistance of Escherichia coli mutantsC Bonny
Laboratoire de Biochimie Vegetale, Universite de Neuchatel, Switzerland
Biochim Biophys Acta 1089:213-9. 1991We previously reported about Escherichia coli transformation experiments yielding streptomycin-resistant cells carrying a C912 to T transition in a plasmid-born 16S rRNA gene...
- Streptomycin and EDTA decrease the number of desmin-negative fibers following stretch injuryMark E T Willems
Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506, USA
Muscle Nerve 32:310-5. 2005b>Streptomycin and ethylene diamine tetraacetic acid (EDTA) were used to examine the role of extracellular calcium in stretch-induced muscle injury. Streptomycin was injected in one group of rats, three times daily for 8 days (S, 300 mg...
- Streptomycin alleviates irinotecan-induced delayed-onset diarrhea in rats by a mechanism other than inhibition of β-glucuronidase activity in intestinal lumenAkinobu Kurita
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo 186 8650, Japan
Cancer Chemother Pharmacol 67:201-13. 2011..clarify the alleviative effect of antibiotics on CPT-11-induced diarrhea, we examined whether penicillin G and streptomycin (SM) alleviate CPT-11-induced delayed-onset diarrhea using three diarrheal models, i.e...
- Streptomycin, errors in mitochondria and ageingRobin Holliday
Biogerontology 6:431-2. 2005
- Rapid speciation of 15 clinically relevant mycobacteria with simultaneous detection of resistance to rifampin, isoniazid, and streptomycin in Mycobacterium tuberculosis complexShubhada Shenai
P D Hinduja National Hospital and Medical Research Centre, Maharashtra, India
Int J Infect Dis 13:46-58. 2009..assay for the accurate identification of 15 clinically relevant species of mycobacteria and for the detection of drug resistance to rifampin (RIF), isoniazid (INH), and streptomycin (STR) in Mycobacterium tuberculosis complex (MTB).
- S-adenosylmethionine activates adpA transcription and promotes streptomycin biosynthesis in Streptomyces griseusSu Kyoung Shin
Department of Biolog ical Science, Institute of Bioscience and Biotechnology, Myongji University, Yongin, Korea
FEMS Microbiol Lett 259:53-9. 2006..The present study demonstrates that exogenous SAM, in a quantity as low as 10 muM, enhanced streptomycin production and adpA transcription in both Streptomyces griseus wild-type strain and mutant HO1, which displays ..
- Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitisClaire Larmonier; Fiscal Year: 2013..adhesion molecules as well as reduced immune tissue infiltration in various model of inflammation including, streptomycin induced diabetes, LPS induced septic shock, ischemia and reperfusion injury...
- Delineation of the molecular mechanisms underlying group A Streptococcus virulencPaul Sumby; Fiscal Year: 2013..ii) FASX binds mRNAs and/or proteins to regulate virulence factor production. We have fused a streptomycin-binding RNA aptamer to FASX that enables the hybrid RNA to be retained within a streptomycin affinity matrix...
- Development of Site-Specific Mutagenesis in Coxiella burnettiJAMES EVANS SAMUEL; Fiscal Year: 2012..specifically target genes, which inactivation results in a screenable phenotype;Mutation of rpsL results in streptomycin resistance and inactivation of waaF to LPS core truncation or com1 or sodC as immunogenic proteins as ..
- Novel Spectinamide Antibiotics for the Treatment of MDR/XDR TuberculosisMichelle M Butler; Fiscal Year: 2013..line agents, ethambutol and pyrazinamide, second-line agents to which the strain is not resistant, such as streptomycin, as well as unproven agents such as linezolid, amoxicillin/clavulanate, clarithromycin, clofazimine and ..
- Novel mycobacterial translocase I inhibitors - a new class of anti-TB drugsVenkata M Reddy; Fiscal Year: 2010..mutants in vitro and has marked synergistic activity in vitro with several antituberculars: Ethambutol (EMB), streptomycin, and the new Sequella drug, SQ109...
- Firing up new treatments against Mycobacterium ulcerans disease (Buruli ulcer)Jacques H Grosset; Fiscal Year: 2013..ulcerans disease and demonstrated that treatment for two months with amikacin (or streptomycin) and rifampin, used in the mouse at doses equipotent to human doses, was highly active (bactericidal)...
- Virulence in Enteroaggregative Escherichia coliJames P Nataro; Fiscal Year: 2013..coli strains tested. The streptomycin- treated conventional mouse, in contrast, serves as a colonization, but not disease, model, which we have used ..
- Symbiosis of E. coli and the Intestinal Microbiota in a Mouse ModelTyrrell Conway; Fiscal Year: 2013..For over a decade, we have used the streptomycin-treated mouse model of intestinal colonization to characterize the functional role of Escherichia coli in the ..
- Development of novel proteins synthesis inhibitors for MDR tuberculosisRICHARD EDWARD LEE; Fiscal Year: 2013..tuberculosis;no cross resistance to existing anti-tuberculosis drugs including those active at the ribosome (Streptomycin, Kanamycin, Capreomycin and Linezolid);good pharmacokinetic profiles including excellent serum and microsomal ..
- Plasma and Intrapulmonary Pharmacokinetics and Pharmacodynamics (PKPD) of AerosolJeffrey Golden; Fiscal Year: 2010..this project is to plan a clinical trial that will administer aerosolized isoniazid (INH), rifampin (RIF) and streptomycin (SM) to healthy volunteers and measure the concentration of each drug in the blood and lungs at set time ..
- A Low Cost, Accurate, and Portable Detection Method for Contaminant Levels in FooJiahuan Ding; Fiscal Year: 2012..low-cost, and label-free quantification of various food contaminants such as melamine, antibiotics such as streptomycin, and foodborne pathogens such as Staphylococcus...
- Mechanisms of mistranslation-mediated mutator responseM Zafri Humayun; Fiscal Year: 2009..discoveries: mistranslation induced by genetic defects in protein synthesis, or exposure to the antibiotic streptomycin, can induce this mutagenic pathway, named TSM for translational stress-induced mutagenesis...
- Growth and Colonization of the Intestine by E. coliTyrrell Conway; Fiscal Year: 2009..Thus, we will thoroughly test the nutrient-niche hypothesis for Escherichia coli in the streptomycin-treated mouse model, which is the only animal model of intestinal colonization that allows competition between ..
- Nanoparticle delivery system for antiturberculosis drugLeonid Heifets; Fiscal Year: 2004..Our preliminary data, the only data on anti-TB drugs, suggest that the MICs for streptomycin and isoniazid were reduced by 4.5-7 fold. Dr...
- Inhaled Aminoglycoside Formulafor Plague and TularemiaJames Talton; Fiscal Year: 2005..this proposal, Nanotherapeutics proposes to investigate inhaled dry-powder formulations of two aminoglycosides, streptomycin and gentamicin, for post-exposure treatment of aerosol exposure of the Category A bioterrorism agents pneumonic ..
- Structural Robustness of Ribosome Functional CentersGerwald Jogl; Fiscal Year: 2013..The first aim of our proposal is to use streptomycin-resistance mutations as a paradigm for examining the mutational robustness of a conserved ribosome functional ..
- Can L-carnitine prevent drug-induced hearing loss?Gilda Kalinec; Fiscal Year: 2004..b) To determine if LCAR can decrease the toxic effects of cisplatin, gentarnicin, neomycin, streptomycin or kanamycin on cultured auditory cell lines...
- Targeting RNA conformation for drug developmentDEV PRIYA ARYA; Fiscal Year: 2012..ribosome has been a well known receptor for antibiotics blocking protein synthesis since the discovery of streptomycin in the 1940s, new antibacterial and antiviral approaches are urgently needed to combat drug resistance, which ..
- PRECLINICAL DEVELOPMENT OF NEW ANTITUBERCULOSIS REGIMENLeonid Heifets; Fiscal Year: 2000..Regimens targeted against MDR-TB will include substitutes for isoniazid, rifampin, pyrazinamide, streptomycin,ethambutol, developed under this program or already available (for example, some quinolones and aminosidine)...
- Molecular mechanism of immune evasion by Yersinia pestisTomas Mustelin; Fiscal Year: 2003..Although several vaccines exist, and Yersinia usually is sensitive to streptomycin and tetracycline type antibiotics, the pneumonic form of the disease is difficult to treat and still often ..
- REGENERATION AND REINNERVATION OF VESTIBULAR HAIR CELLSMANNING CORREIA; Fiscal Year: 1999..regeneration and synaptic reinnervation of regenerated hair cells by primary afferents and efferents following streptomycin (SM) ototoxicity. The semicircular canals (SCCs) will be studied...
- MOLECULAR BASIS OF E. COLI COLONIZATIONPaul Cohen; Fiscal Year: 1990..coli and S. typhimurium known to possess an impaired ability to colonize the large intestines of streptomycin-treated mice, relative to the parent strain, will be assayed for chemotaxis toward mucus and the ability to ..
- Rapid Detection of Mycobacterium tuberculosisSusan Dorman; Fiscal Year: 2007..of this K23 proposal are 1) to optimize the MODS assay for drug susceptibility testing for ethambutol, streptomycin, and pyrazinamide; 2) to determine the performance characteristics of MODS for detection of MTB among pulmonary ..
- DEVELOPMENT OF NOVEL PHARMACOPHORE WITH ANTI-TB ACTIVITYZe Qi Xu; Fiscal Year: 2001..demonstrated that it was active against Mycobacterium tuberculosis strains resistant to isoniazid, rifampin, streptomycin, and ethambutol, respectively...
- ADAPTIVE CHANGES IN VESTIBULAR SYSTEMWerner Graf; Fiscal Year: 1991..application of thyroxin antagonists, and at the species-specific level of the flatfish by utilizing chemical (streptomycin, kainic acid) and surgical lesion experiments in the vestibular and olivo-cerebellar systems, as well as ..
- TRANSLATIONAL ATTENUATION AS A GENE REGULATORPAUL LOVETT; Fiscal Year: 1993..An inducible cat gene from a gram-negative and an inducible streptomycin- resistance gene from a gram-positive will be characterized with respect to the induction mechanisms.
- TRANSPOSITION OF TN7Nancy Craig; Fiscal Year: 1999..reaction, the transposition of the bacterial transposition Tn7 which encodes resistances to trimethoprim and to streptomycin and spectinomycin...
- Function of the Vestibular System Following RegenerationJ Dickman; Fiscal Year: 2005..We have recently developed a method for administration of streptomycin that results in complete hair cell loss and afferent denervation of the vestibular organs in adult pigeons at a ..
- Project ImpACT:Important Achievements of Clinical TrialSteven Goodman; Fiscal Year: 2005..areas of medicine and public health since 1948, the year of the first large-scale RCT in medicine, the British Streptomycin trial...
- GENETIC STUDIES OF NONSYNDROMIC DEAFNESSWalter Nance; Fiscal Year: 2001..In addition, blood spots from all available students at the School for the Deaf in Ulaanbaatar will be screened for the mitochondrial mutation that is associated with sensitivity to streptomycin.
- APTAMER BASED BACTERIAL INHIBITION SYSTEMJonathan Blum; Fiscal Year: 2001..Additional selections will be used to identify aptamers that have streptomycin-like activities...
- TAS::75 0885::TAS EFFICACY OF ORAL AMINOGLYCOSIDE-COCHLEATE FORMULATIONSMoses Sing Sum Chow; Fiscal Year: 2010..The phase I objective is to test the feasibility of using a specific nanotechnology to develop a therapeutically effective oral formulation of streptomycin against infectious agents such as Tb.
- HIV-1 PROTEASE INHIBITORS FROM RANDOM PEPTIDE LIBRARIESROBERT BALINT; Fiscal Year: 1992..Recombinant HIV-1 protease will be inducibly expressed in streptomycin-resistant strains of E...
- Epidemiologic Methods: Resistant Nosocomial InfectionsMarc Lipsitch; Fiscal Year: 2004..This will in turn lead to better practices to reduce the incidence of ARNI. ..
- A NOVEL FROZEN STORAGE SYSTEM FOR CORD BLOOD STEM CELLSERIK WOODS; Fiscal Year: 2004....
- Microarray Analysis of Plague-Induced ApoptosisJAMES BLISKA; Fiscal Year: 2003..abstract_text> ..
- MOSQUITO IMMUNITY FUNCTIONSAnn Fallon; Fiscal Year: 2003..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
- EXPANSION OF PANCREATIC ISLETS USING A NOVEL BIOMATERIALERIK WOODS; Fiscal Year: 2002..who will serve as their Phase III partner for both of these products. These products will have importance in enhancing islet transplantation as a treatment and/or cure for type I diabetes. PROPOSED COMMERCIAL APPLICATION: Not available ..
- POPULATION BIOLOGY OF BACTERIAL VIRUSES AND PLASMIDSBruce Levin; Fiscal Year: 2002....
- Real-time PCR diagnostic kit for Giardia and CryptosporidiumEric Houpt; Fiscal Year: 2006..A Phase II application is anticipated to validate the final diagnostic test product against immunoassay for an FDA 501 (k) medical device application. [unreadable] [unreadable] [unreadable]..
- ECDYSONE EFFECTS ON MOSQUITO CELL PROLIFERATIONAnn Fallon; Fiscal Year: 2001..Results of this study will provide novel insights into the effects of 20E on cell growth and proliferation, which are directly relevant to efforts to control vector-borne disease by genetic manipulation of insect vectors. ..
- MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASELars Eckmann; Fiscal Year: 2010..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
- Genotypes of Helicobacter Pylori in West AfricaRichard Adegbola; Fiscal Year: 2005..pylori colonization in West Africa differ from those seen in industrialized nations, and enable the development of appropriate treatment strategies for communities such as The Gambia. ..
- Mechanism of Opiate Induced Audiovestibular DysfunctionGail Ishiyama; Fiscal Year: 2006....
- VIRULENCE MECHANISMS OF SALMONELLA TYPHIANDREAS BAUMLER; Fiscal Year: 2006..This outcome will be significant because it promises to establish a new paradigm in host pathogen interaction that may be applicable to a number of other capsulated pathogens. [unreadable] [unreadable] [unreadable]..
- HOST DEFENSES AGAINST PATHOGENIC E. coliLars Eckmann; Fiscal Year: 2007..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
- NEUROETHOLOGY OF VOCAL COMMUNICATIONAndrea Simmons; Fiscal Year: 2006..abstract_text> ..
- CHILDHOOD VACCINES AND DENTAL CARIES IMMUNITYDaniel Smith; Fiscal Year: 2007..unreadable]..
- Mucosal immune regulation in murine amebic colitisEric Houpt; Fiscal Year: 2007..The comprehensive approach in training and research laid out in this research proposal will guide the applicant towards his goal of being an independent investigator in immunoparasitology. ..
- Multiplex bead-PCR diagnosis for AIDS diarrheaEric Houpt; Fiscal Year: 2007..Finally, syndrome-based multiplex diagnosis is the platform of the future for clinical microbiology, and if this assay works on stool it should work on sputum, blood, or spinal fluid. [unreadable] [unreadable] [unreadable]..
- Targeted DNA extraction for Tuberculosis PCR from sputumEric Houpt; Fiscal Year: 2007..The most sensitive procedure will be taken in Phase II and adapted to high-throughput DNA extraction platforms and compared against the standard E- MTD assay. [unreadable] [unreadable] [unreadable]..
- Training in Translational Lung ResearchNeil Schluger; Fiscal Year: 2008..abstract_text> ..
- MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATIONLars Eckmann; Fiscal Year: 2008..abstract_text> ..
- Dental Pulp Derived Stem Cells: Optimizing Collection and CryopreservationERIK WOODS; Fiscal Year: 2008..This proposed project would optimize methods for processing and freezing these cells for ease of distribution for research, testing, and eventually clinical use. [unreadable] [unreadable] [unreadable]..
- AUTOMATED CLOSED SYSTEM FOR DMSO REMOVAL FROM PERIPHERAL BLOOD STEM CELLSERIK WOODS; Fiscal Year: 2008..The goal of this research is to produce a device to easily remove DMSO from PBSC before they are transplanted, increasing effectiveness of the cells and reducing potential complications. [unreadable] [unreadable] [unreadable]..
- MODULATION OF HOST SIGNALING FUNCTIONS BY YERSINIA YOPSJAMES BLISKA; Fiscal Year: 2009..In aim 2, levels of TNF and IFN in tissues of mice infected with wild-type, Yop mutant or LcrV mutant Yersinia will be measured. Our results will elucidate an essential mechanism of Yersinia pathogenesis. ..
- NBCe1 and n1: Crystal Structure DeterminationHARRY GILL; Fiscal Year: 2007..The proposed study will provide key insights on the molecular mechanisms of renal HCO3- transport and will enhance our understanding of processes fundamental to renal disease. [unreadable] [unreadable] [unreadable]..
- Duke University Center for Translational ResearchRichard Frothingham; Fiscal Year: 2006....