uteroglobin

Summary

Summary: A protein fraction of pregnant uterine fluid which can induce and regulate blastocystic development. Blastokinin is thought to be similar or identical to uteroglobin. Presence in uterine fluid regulated by progesterone.

Top Publications

  1. ncbi Identification of bronchioalveolar stem cells in normal lung and lung cancer
    Carla F Bender Kim
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell 121:823-35. 2005
  2. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
  3. pmc Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction
    Adam Giangreco
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Pathol 161:173-82. 2002
  4. pmc Uteroglobin suppresses allergen-induced TH2 differentiation by down-regulating the expression of serum amyloid A and SOCS-3 genes
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Building 10, Rm 9D42, 10, Center Drive, Bethesda, MD 20892 1830, USA
    FEBS Lett 580:6022-6. 2006
  5. ncbi Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion
    K U Hong
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Am J Respir Cell Mol Biol 24:671-81. 2001
  6. ncbi Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis
    Claire de Burbure
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Clos Chapelle aux Champs 30, bte 3054, B 1200 Brussels, Belgium
    Chest 131:172-9. 2007
  7. ncbi Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily
    Anil B Mukherjee
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institute of Health, Building 10, Bethesda, Maryland 20892 1830, USA
    Endocr Rev 28:707-25. 2007
  8. ncbi Targeted cell replacement with bone marrow cells for airway epithelial regeneration
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto Lung Transplant Program, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L740-52. 2007
  9. ncbi Recognition of HLA-A2-restricted mammaglobin-A-derived epitopes by CD8+ cytotoxic T lymphocytes from breast cancer patients
    André Jaramillo
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Breast Cancer Res Treat 88:29-41. 2004
  10. ncbi Mammaglobin a: a promising marker for breast cancer
    Neil O'Brien
    Department of Nuclear Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Clin Chem 48:1362-4. 2002

Research Grants

Detail Information

Publications254 found, 100 shown here

  1. ncbi Identification of bronchioalveolar stem cells in normal lung and lung cancer
    Carla F Bender Kim
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell 121:823-35. 2005
    ..Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to BASCs as the putative cells of origin for this subtype of lung cancer...
  2. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    ..Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells...
  3. pmc Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction
    Adam Giangreco
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Pathol 161:173-82. 2002
    ..These studies identify a BADJ-associated, NEB-independent, CCSP-expressing stem cell population in terminal bronchioles and support the notion that regiospecific stem cell niches function to maintain epithelial diversity after injury...
  4. pmc Uteroglobin suppresses allergen-induced TH2 differentiation by down-regulating the expression of serum amyloid A and SOCS-3 genes
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Building 10, Rm 9D42, 10, Center Drive, Bethesda, MD 20892 1830, USA
    FEBS Lett 580:6022-6. 2006
    ..The mammalian airway epithelia constitutively express uteroglobin (UG), a protein with potent anti-inflammatory and anti-chemotactic properties...
  5. ncbi Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion
    K U Hong
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Am J Respir Cell Mol Biol 24:671-81. 2001
    ..These results support the notion that vCE cells represent either an airway stem cell or are critical for stem cell maintenance, and suggest that PNECs are not sufficient for epithelial renewal...
  6. ncbi Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis
    Claire de Burbure
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Clos Chapelle aux Champs 30, bte 3054, B 1200 Brussels, Belgium
    Chest 131:172-9. 2007
    b>Uteroglobin-related protein 1 (UGRP1) and Clara cell protein (CC16), members of the secretoglobin family, increasingly appear to play a role in airway inflammatory response.
  7. ncbi Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily
    Anil B Mukherjee
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institute of Health, Building 10, Bethesda, Maryland 20892 1830, USA
    Endocr Rev 28:707-25. 2007
    Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology...
  8. ncbi Targeted cell replacement with bone marrow cells for airway epithelial regeneration
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto Lung Transplant Program, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L740-52. 2007
    ..Some BMC cultured in vitro over time also expressed GFP transgene, suggesting epithelial transdifferentiation of the BMC. The results indicate that targeted delivery of BMC can promote airway regeneration...
  9. ncbi Recognition of HLA-A2-restricted mammaglobin-A-derived epitopes by CD8+ cytotoxic T lymphocytes from breast cancer patients
    André Jaramillo
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Breast Cancer Res Treat 88:29-41. 2004
    ..1+ breast cancer cell line. In conclusion, these results demonstrate the immunotherapeutic potential of mammaglobin-A for the treatment and prevention of breast cancer...
  10. ncbi Mammaglobin a: a promising marker for breast cancer
    Neil O'Brien
    Department of Nuclear Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Clin Chem 48:1362-4. 2002
  11. ncbi Response of established human breast tumors to vaccination with mammaglobin-A cDNA
    Kishore Narayanan
    Department of Surgery, Washington University School of Medicine, Box 8109 3328, CSRB, 660 S Euclid Ave, St Louis, MO, 63110, USA
    J Natl Cancer Inst 96:1388-96. 2004
    ..The characterization of immune responses against this highly expressed breast cancer-specific antigen would be of value in the development of new therapeutic strategies for breast cancer...
  12. ncbi A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney
    R Burmeister
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Biol Chem 276:13295-301. 2001
    ..These findings identify a cellular pathway consisting of a CCSP-binding protein (cubilin) and an endocytic coreceptor (megalin) responsible for tissue-specific uptake of CCSP and associated ligands...
  13. ncbi Mammaglobin, a breast-specific gene, and its utility as a marker for breast cancer
    T P Fleming
    Department of Surgery Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Ann N Y Acad Sci 923:78-89. 2000
    ..that includes rat estramustine binding protein (EMBP)/prostatein and human Clara cell 10-kDa protein (CC10)/uteroglobin. Among normal adult tissues, mammaglobin mRNA expression has been detected only in the mammary gland...
  14. ncbi Uteroglobin: a novel cytokine?
    A B Mukherjee
    Section on Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Cell Mol Life Sci 55:771-87. 1999
    Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, multifunctional protein secreted by the mucosal epithelial of virtually all mammals. It is present in the blood and in other body fluids including urine...
  15. ncbi Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium
    Xiao Yang Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 87:527-39. 2007
    ..The collective results suggest a novel model of BOA formation via hASH1-induced suppression of the apoptotic pathway. Our study yields a promising new preclinical tool for chemoprevention of peripheral lung carcinomas...
  16. pmc Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma
    Keiichi Inoue
    Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan
    Allergol Int 57:57-64. 2008
    b>Uteroglobin-related protein 1 (UGRP1) is a secretory protein expressed in the airways and is speculated to have anti-inflammatory activity...
  17. pmc A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma
    Tomoaki Niimi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Am J Hum Genet 70:718-25. 2002
    ..In the present article, we describe UGRP1 (encoding uteroglobin-related protein 1) as one of asthma-susceptibility genes that is located on chromosome 5q31-q32...
  18. ncbi Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease
    Yu Yang
    Department of Endocrinology, 1st Clinical Hospital, China Medical University, Shenyang, North 2nd Rd, Heping District, Shenyang, Liaoning, 110001, China
    J Hum Genet 50:574-82. 2005
    ..But those individuals who were TT homozygous at IRF1 6477 T/G locus seemed to be attacked by GD much earlier than others...
  19. ncbi UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor
    T Niimi
    Laboratory of Metabolism, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Endocrinol 15:2021-36. 2001
    ..is a secreted protein, forms a homodimer, and exhibits an amino acid sequence similar to that seen in the uteroglobin/Clara cell secretory protein family of proteins...
  20. ncbi A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects
    J S LaKind
    LaKind Associates, LLC, Catonsville, MD, USA
    Biomarkers 12:445-67. 2007
    ..is the serum concentration of the Clara cell secretory protein (CC16, sometimes referred to as CC10 or uteroglobin). In this review, we examine serum CC16's relation to asthma aetiology and exacerbation...
  21. pmc Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells
    David H Tompkins
    Division of Pulmonary Biology in the Perinatal Institute, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 4:e8248. 2009
    ..Sox2 is required for proliferation and differentiation of Clara cells that serve as the progenitor cells from which Clara, ciliated, and goblet cells are derived...
  22. ncbi Airway regeneration: the role of the Clara cell secretory protein and the cells that express it
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, and the McEwen Centre for Regenerative Medicine, Toronto, Ontario, Canada
    Cytotherapy 11:676-87. 2009
    ..The use of this protein or CCSP-expressing cells as an indication of biologic processes that contribute to lung injury or repair is highlighted...
  23. pmc Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 9:49. 2009
    ..This study was designed to assess and compare the diagnostic accuracy of biological markers for ALI/ARDS with ventilator-associated pneumonia (VAP)...
  24. ncbi Changes in serum pneumoproteins caused by short-term exposures to nitrogen trichloride in indoor chlorinated swimming pools
    Sylviane Carbonnelle
    Industrial Toxicology Unit, Catholic University of Louvain, B 1200 Brussels, Belgium
    Biomarkers 7:464-78. 2002
    ..In view of the increasing and widespread human exposure to this gas not only in indoor pools but also in a variety of other situations, these findings warrant further study...
  25. ncbi Clara cell proteins
    G Singh
    Department of Veterans Affairs and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    Ann N Y Acad Sci 923:43-58. 2000
    ..These cells are known to secrete a variety of proteins, including Clara cell 10-kDa protein/uteroglobin. This protein consists of a homodimer of 70-77 amino acid polypeptides arranged in antiparallel fashion...
  26. ncbi Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps
    Mikael Benson
    Laboratory for Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
    J Allergy Clin Immunol 113:1137-43. 2004
    ..Treatment with local glucocorticoids (GCs) decreases symptoms and the size of nasal polyps. This might depend on the downregulation of proinflammatory genes, as well as the upregulation of anti-inflammatory genes...
  27. ncbi Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells
    T M Watson
    Division of Respiratory Biology and Toxicology, Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1523-30. 2001
    ..These findings identify new roles for Clara cells and their secretions in airway homeostasis...
  28. ncbi CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway
    Susan D Reynolds
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Physiol Lung Cell Mol Physiol 293:L114-23. 2007
    ....
  29. ncbi RT-PCR determination of maspin and mammaglobin B in peripheral blood of healthy donors and breast cancer patients
    L Mercatali
    Istituto Oncologico Romagnolo, Forli, Italy
    Ann Oncol 17:424-8. 2006
    ..To define better the potential and limits of the two markers for diagnostic purposes, blood positivity was analyzed in relation to clinical, pathological and biological tumor characteristics...
  30. ncbi Effects of antiflammins on transglutaminase and phospholipase A2 activation by transglutaminase
    Juan Jose Moreno
    Department of Physiology, Faculty of Pharmacy, Barcelona University, Barcelona, Spain
    Int Immunopharmacol 6:300-3. 2006
    ..named antiflammins (AFs), corresponding to a region with high amino acid similarity between lipocortin-1 and uteroglobin were tested for their ability to inhibit transglutaminase (TG) and low-molecular-mass phospholipase A2 (PLA2)...
  31. ncbi Mice lacking uteroglobin are highly susceptible to developing pulmonary fibrosis
    Yi Ching Lee
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Building 10, Rm 9D42, 10, Center Drive, Bethesda, MD 20892 1830, USA
    FEBS Lett 580:4515-20. 2006
    b>Uteroglobin (UG) is an anti-inflammatory protein secreted by the airway epithelia of all mammals...
  32. ncbi mRNA markers of breast cancer nodal metastases: comparison between mammaglobin and carcinoembryonic antigen in 248 patients
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, 66100 Chieti, Italy
    J Pathol 195:186-90. 2001
    ..The detection sensitivity of the mammaglobin RT-PCR is far superior to that of the CEA RT-PCR, allowing the diagnosis of occult metastases in nearly one-third of cases...
  33. ncbi Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort
    D A Lomas
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Thorax 63:1058-63. 2008
    ..Circulating levels of Clara cell secretory protein-16 (CC-16) have been linked to Clara cell toxicity. It has therefore been suggested that this protein may be a useful marker of chronic obstructive pulmonary disease (COPD)...
  34. ncbi Altered progenitor cell and cytokine profiles in bronchiolitis obliterans syndrome
    Sarah E Gilpin
    University Health Network, Latner Thoracic Surgery Research Laboratories, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 31:222-8. 2012
    ..Interplay between these populations has not yet been studied in bronchiolitis obliterans syndrome (BOS) post-lung transplant...
  35. ncbi Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung
    L Zhou
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Histochem Cytochem 44:1183-93. 1996
    ..The early expression of TTF-1 and HNF-3beta, preceding and overlapping that of pro-SP-B, mature SP-B, pro-SP-C, and CCSP, supports a regulatory role for TTF-1 and HNF-3beta in lung-specific gene expression...
  36. ncbi Clara cell secretory protein (CC16): features as a peripheral lung biomarker
    F Broeckaert
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, School of Public Health, Catholic University of Louvain, B 1200 Brussels, Belgium
    Ann N Y Acad Sci 923:68-77. 2000
    ....
  37. pmc Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study
    Sonja M Bjerk
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e56249. 2013
    ..Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do not currently exist...
  38. ncbi Mammaglobin expression in gynecologic malignancies and malignant effusions detected by nested reverse transcriptase-polymerase chain reaction
    Kurt Grünewald
    Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    Lab Invest 82:1147-53. 2002
    ....
  39. ncbi Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells
    Partha P Manna
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Breast Cancer Res Treat 79:133-6. 2003
    ..This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer...
  40. ncbi Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity
    Bhabadeb Chowdhury
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, Bethesda, MD 20892 1830, USA
    Biochem Biophys Res Commun 295:877-83. 2002
    b>Uteroglobin (UG) is an anti-inflammatory, secreted protein with soluble phospholipase A2 (sPLA2)-inhibitory activity. However, the mechanism by which UG inhibits sPLA2 activity is unknown...
  41. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ....
  42. pmc Selective targeted delivery of the TNF-alpha receptor p75 and uteroglobin to the vasculature of inflamed tissues: a preliminary report
    Elisa Ventura
    Laboratory of Therapeutic Recombinant Proteins, Centro Biotecnologie Avanzate, Largo Rosanna Benzi, 1016132 Genoa, Italy
    BMC Biotechnol 11:104. 2011
    ..We hypothesized that the specific targeting of TNF-alpha antagonists to inflamed tissues could increase drug efficacy and reduce side effects...
  43. pmc Short-term changes in respiratory biomarkers after swimming in a chlorinated pool
    Laia Font-Ribera
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 118:1538-44. 2010
    ..Swimming in chlorinated pools involves exposure to disinfection by-products (DBPs) and has been associated with impaired respiratory health...
  44. ncbi Mammaglobin in normal human sweat glands and human sweat gland tumors
    Anna Sjödin
    J Invest Dermatol 121:428-9. 2003
  45. ncbi Clara cell secretory protein is reduced in equine recurrent airway obstruction
    P Katavolos
    Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Vet Pathol 46:604-13. 2009
    ..Together, these preliminary findings suggest that reduced production of CCSP and subcellular changes in Clara cells are features of chronic environmentally induced lung inflammation in horses...
  46. ncbi Cloning, characterization, and steroid-dependent posttranscriptional processing of RUSH-1 alpha and beta, two uteroglobin promoter-binding proteins
    A Hayward-Lester
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Mol Endocrinol 10:1335-49. 1996
    ..UV cross-linking to identify four proteins that bind to the 203-bp 5'-flanking region (-194/ +9) of the rabbit uteroglobin gene...
  47. ncbi The uteroglobin fold
    I Callebaut
    Systèmes moléculaires et Biologie structurale, Laboratoire de Minéralogie Cristallographie Paris LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris, France
    Ann N Y Acad Sci 923:90-112. 2000
    b>Uteroglobin (UTG) forms a fascinating homodimeric structure that binds small- to medium-sized ligands through an internal hydrophobic cavity, located at the interface between the two monomers...
  48. ncbi Pulmonary phenotype of CCSP/UG deficient mice: a consequence of CCSP deficiency or altered Clara cell function?
    B R Stripp
    Department of Environmental Medicine, University of Rochester, Box EHSC, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Ann N Y Acad Sci 923:202-9. 2000
    ..Moreover, CCSP-/-1 mice represent a valuable tool for probing functional roles for Clara cells in regulation of airway lining fluid composition and lung pollutant susceptibility...
  49. ncbi Clara cell secretory protein deficiency alters clara cell secretory apparatus and the protein composition of airway lining fluid
    Barry R Stripp
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Respir Cell Mol Biol 27:170-8. 2002
    ..We conclude that CCSP is required for the appearance of Clara cell secretory granules and that functional changes to Clara cells that result from CCSP deficiency lead to alterations in the composition of epithelial lining fluid...
  50. ncbi Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia
    C W White
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 25:51-9. 2001
    ..Taken together, these data indicate that specific surfactant proteins are upregulated at both the pretranslational and post-translational levels in distal lung epithelium during adaptation to hyperoxia in the newborn rat...
  51. ncbi Demonstration of different forms of the anti-inflammatory proteins lipocortin-1 and Clara cell protein-16 in human nasal and bronchoalveolar lavage fluids
    M Lindahl
    Department of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
    Electrophoresis 20:881-90. 1999
    ..Furthermore, the identification of different forms of the two proteins makes possible more detailed studies on the role of these proteins in inflammatory disease processes and anti-inflammatory therapies...
  52. ncbi Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair
    Liang Hua Bin
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 171:924-30. 2003
    ..HIN-2 is identical with a recently identified protein called uteroglobin-related protein 1 (UGRP1)...
  53. ncbi The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E
    Dimitry A Chistiakov
    Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 1st Dorozhny Proezd 1, 117545, Moscow, Russia
    J Appl Genet 52:201-7. 2011
    The human secretoglobin 3A2 (SCGB3A2) gene encoding secretory uteroglobin-related protein 1 (UGRP1) resides on the chromosome region 5q31-33 that harbors a susceptibility locus to several autoimmune and inflammatory diseases, including ..
  54. ncbi Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 64:149-57. 2009
    ....
  55. ncbi Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys
    John T Coppens
    Department of Anatomy, Physiology and Cell Biology, University of California, Davis, California 95616 8732, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1155-62. 2007
    ....
  56. ncbi Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients
    Magnus Nord
    Department of Medical Nutrition, Karolinska Institute, Novum, Huddinge University Hospital, Stockholm, Sweden
    Transplantation 73:1264-9. 2002
    ..We asked whether this molecule could have a role in the development of BOS...
  57. ncbi Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population
    Jyotsna Batra
    Institute of Genomics and Integrative Biology, Delhi, India
    Int Arch Allergy Immunol 136:1-6. 2005
    The secretory protein, uteroglobin-related protein 1 (UGRP1), is mainly expressed in the lung and trachea and has recently been implicated in asthma...
  58. ncbi Pseudomonas aeruginosa and tumor necrosis factor-alpha attenuate Clara cell secretory protein promoter function
    Kevin S Harrod
    Asthma and Pulmonary Immunology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, New Mexico 87108, USA
    Am J Respir Cell Mol Biol 26:216-23. 2002
    ..a. involves, in part, autocrine/paracrine secretion of TNF-alpha, which in turn regulates CCSP transcription through cis-active elements in the proximal promoter region...
  59. ncbi Serum CC-10 in inflammatory lung diseases
    Qing Ye
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Respiration 71:505-10. 2004
    ..Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear...
  60. pmc Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation
    Yoshihiko Chiba
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Lett 97:123-9. 2005
    ..The uteroglobin-related protein (UGRP) 1 was proposed to be an asthma candidate gene and play a role in regulating lung ..
  61. pmc Clara cells attenuate the inflammatory response through regulation of macrophage behavior
    Joshua C Snyder
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 42:161-71. 2010
    ....
  62. ncbi Overexpression of mammaglobin B in epithelial ovarian carcinomas
    Renata A Tassi
    Division of Gynecologic Oncology, University of Brescia, Brescia, Italy
    Gynecol Oncol 105:578-85. 2007
    Mammaglobin B is a uteroglobin gene family member recently found highly differentially expressed in serous papillary ovarian cancer by gene expression profiling...
  63. ncbi Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation
    Anna Sjödin
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Anticancer Res 28:1493-8. 2008
    ..Mammaglobin has been shown to be overexpressed in breast tumor tissue, indicating that mammaglobin might confer a growth advantage to mammaglobin-expressing tumor cells...
  64. pmc Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli
    Anne Karina T Perl
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 33:455-62. 2005
    ..Conditional expression of Cre-recombinase in the respiratory epithelium provides a useful model for the study of gene expression and function in the mouse respiratory tract and in the lung...
  65. pmc beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium
    Anna C Zemke
    Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 41:535-43. 2009
    ..Thus, beta-catenin was not necessary for maintenance or efficient repair of the bronchiolar epithelium...
  66. pmc Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury
    Jonathan A Kropski
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Chest 135:1440-7. 2009
    ..We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE)...
  67. ncbi Clara cell 16 protein in COPD sputum: a marker of small airways damage?
    Fulvio Braido
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Pad Maragliano, Largo R Benzi, 10 16132 Genova, Italy
    Respir Med 101:2119-24. 2007
    ..This protein has never been related to patients' lung function tests, blood gases parameters and diseases severity...
  68. ncbi Cord blood Clara cell protein CC16 predicts the development of bronchopulmonary dysplasia
    Alexandra J J Schrama
    Department of Pediatrics, Neonatal Center, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Pediatr 167:1305-12. 2008
    ..Future studies are needed to assess whether the early administration of recombinant human CC16 in preterm infants with low cord blood CC16 prevents the development of BPD...
  69. ncbi Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways
    Susan D Reynolds
    Departments of Environmental and Occupational Health, and Pediatrics, University of Pittsburgh, Pennsylvania 15260, USA
    Am J Respir Crit Care Med 166:1498-509. 2002
    ..Altered expression of secretoglobins in airway disease may contribute to immunoregulatory perturbations commonly seen in chronic airway disease...
  70. pmc Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans
    Reiko Kurotani
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA
    Lung Cancer 71:42-8. 2011
    Secretoglobin (SCGB) 3A2, also called uteroglobin-related protein (UGRP) 1, is a downstream target for a homeodomain transcription factor NKX2-1, which is critical for the development of lung, thyroid and ventral forebrain...
  71. ncbi Antiflammins. Bioactive peptides derived from uteroglobin
    L Miele
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    Ann N Y Acad Sci 923:128-40. 2000
    b>Uteroglobin/Clara cell 10-kDa protein (UG/CC10) is a hormonally regulated small secretory protein that has a variety of in vitro and in vivo pharmacological effects...
  72. ncbi Clara cell secretory protein increases phagocytic and decreases oxidative activity of neutrophils
    P Katavolos
    Department of Pathobiology, University of Guelph, Ontario, Canada
    Vet Immunol Immunopathol 139:1-9. 2011
    ..Presence in the nucleus suggests a potential transcriptional role of CCSP in neutrophils...
  73. ncbi The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression
    R I Linnoila
    Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, NIH, 9610 Medical Center Drive, Suite 300, Rockville, MD 20850, USA
    Ann N Y Acad Sci 923:249-67. 2000
    ..The data suggest that downregulation of CC10 contributes to carcinogenesis because CC10 antagonizes the neoplastic phenotype...
  74. pmc Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese
    Anand Kumar Andiappan
    Department of Biological Sciences, National University of Singapore, Singapore
    BMC Med Genet 12:39. 2011
    b>Uteroglobin-Related Protein 1 (UGRP1) is a secretoglobulin protein which has been suggested to play a role in lung inflammation and allergic diseases...
  75. ncbi Conditional gene expression in the respiratory epithelium of the mouse
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
    Transgenic Res 11:21-9. 2002
    ..The SP-C-rtTA and CCSP-rtTA activator mice control the expression of transgenes in the developing and mature respiratory epithelium, and will be useful for the study of gene function in the lung...
  76. ncbi Innate immunity proteins in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    Maria Tsoumakidou
    Department of Thoracic Medicine, University Hospital of Heraklion, Heraklion, Greece
    Exp Lung Res 36:373-80. 2010
    ..019). beta-Defensin-2 was not detected in BALF. In conclusion, in COPD, secretion of CC16 and beta-defensin-2 might be suppressed, whereas SLPI and elafin secretion is up-regulated. In IPF, only CC16 secretion is up-regulated...
  77. pmc Clara cell 10-kD protein suppresses chitinase 3-like 1 expression associated with eosinophilic chronic rhinosinusitis
    Heng Wang
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, P R China
    Am J Respir Crit Care Med 181:908-16. 2010
    ..Clara cell 10-kD (CC10) protein, an antiinflammatory molecule, is involved in inflammatory upper airway diseases, but its regulatory role is unclear, particularly in the process of chronic rhinosinusitis (CRS)...
  78. ncbi Regulation of the Clara cell secretory protein/uteroglobin promoter in lung
    M Nord
    Department of Medical Nutrition, Karolinska Institute, Novum, Huddinge University Hospital, SE 141 86 Huddinge, Sweden
    Ann N Y Acad Sci 923:154-65. 2000
    Clara cell secretory protein/uteroglobin (CCSP/UG) is specifically expressed in the conducting airway epithelium of the lung in a differentiation-dependent manner...
  79. ncbi Transcriptional regulation of CCSP by interferon-gamma in vitro and in vivo
    P L Ramsay
    Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Lung Cell Mol Physiol 284:L108-18. 2003
    ..Additionally, IFN-gamma-induced expression of CCSP was mediated indirectly through an interferon regulatory factor-1-mediated increase in hepatocyte nuclear factor-3beta...
  80. ncbi Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein
    Chih Hsing Hung
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 114:664-70. 2004
    ..Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown...
  81. ncbi Mammaglobin a in breast cancer: existence of multiple molecular forms
    Neil A O'Brien
    Department of Nuclear Medicine, St Vincent s University Hospital, Dublin, Ireland
    Int J Cancer 114:623-7. 2005
    ..As expression of MGA is almost breast specific, it is a promising marker for breast cancer. Its most immediate use is likely to be in detecting micrometastases from breast cancer...
  82. pmc Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction
    J M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 11:561-7. 2011
    ..02. Elevated CC16 levels were associated with increased odds of PGD after lung transplantation. Damage to airway epithelium or altered alveolar permeability as a result of lung ischemia and reperfusion may explain this association...
  83. pmc Application of a multigene reverse transcription-PCR assay for detection of mammaglobin and complementary transcribed genes in breast cancer lymph nodes
    Barbara K Zehentner
    Corixa, 1124 Columbia St, Seattle, WA 98104, USA
    Clin Chem 48:1225-31. 2002
    ..Collectively the expression profile of these four genes could be used as a diagnostic and prognostic indicator for breast cancer...
  84. ncbi Mammaglobin-A is a tumor-associated antigen in human breast carcinoma
    Yoshiyuki Tanaka
    Washington University School of Medicine, Department of Surgery, St Louis, MO 63110, USA
    Surgery 133:74-80. 2003
    ..In this study, we attempted to identify immunogenic T cell epitopes restricted by human leukocyte antigen (HLA)-A2 in mammaglobin-A protein...
  85. ncbi Uteroglobin suppresses SCCA gene expression associated with allergic asthma
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:9761-4. 2005
    b>Uteroglobin (UG), the founding member of the Secretoglobin superfamily, is a potent anti-inflammatory protein constitutively expressed at a high level in the airway epithelia of all mammals...
  86. pmc Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 10:6. 2010
    ..In the present study we investigated whether plasma levels of lung-specific biological markers can be used to evaluate lung injury in patients with ALI/ARDS and patients without lung injury at onset of mechanical ventilation...
  87. ncbi Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children
    X M Gioldassi
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26 500 Patras, Greece
    J Pharm Biomed Anal 34:823-6. 2004
    ..001) of CC16 in serum as compared to healthy ones. It is, therefore, concluded that CC16 may be a useful diagnostic index of bronchial asthma in the early child-age...
  88. ncbi Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells
    G C Kundu
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Ann N Y Acad Sci 923:234-48. 2000
    b>Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties...
  89. ncbi Clara-cell secretory protein in preterm infants' tracheal aspirates correlates with maturity and increases in infection
    P Lassus
    Hospital for Children and Adolescents, and Department for Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
    Pediatr Pulmonol 30:466-9. 2000
    ..05). We suggest that pulmonary CCSP correlates with both gestational and postnatal age, and increases in response to infection in infants with respiratory distress during the early postnatal period...
  90. ncbi Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia
    P L Ramsay
    Department of Pediatrics, Baylor College of Medicine, Houston Texas, USA
    Am J Respir Crit Care Med 164:155-61. 2001
    ....
  91. ncbi Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice
    F Zheng
    Section on Developmental Genetics, Heritable Disorders Branch, The National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Nat Med 5:1018-25. 1999
    ..models (gene knockout and antisense transgenic), both manifesting deficiency of an anti-inflammatory protein, uteroglobin (UG), develop almost all of the pathologic features of human IgA nephropathy...
  92. ncbi The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers
    Yung Chang Lin
    Department of Internal Medicine, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Cancer Lett 191:93-9. 2003
    ..When combined hMAM mRNA with CEA or CA 15.3, the sensitivity rate were 81% and 90%, respectively (P=0.045). In conclusion, the hMAM mRNA RT-PCR can be an adjunct in detecting metastatic breast cancer...
  93. ncbi Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:32897-904. 2005
    ..inverse relationship exists between the levels of PGF2alpha and a steroid-inducible anti-inflammatory protein, uteroglobin. Here we report that, in NIH 3T3 fibroblasts and human uterine smooth muscle cells, FP signaling is mediated ..
  94. ncbi Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines
    M Wolf
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    Hum Mol Genet 1:371-8. 1992
    ..Comparison of the amino acid sequences showed that CC10 is homologous to rabbit uteroglobin. Here we present further evidence that human CC10 is the human counterpart of rabbit uteroglobin...
  95. ncbi Structure and regulation of the murine Clara cell secretory protein gene
    B R Stripp
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 2899
    Genomics 20:27-35. 1994
    ..of the murine CCSP gene was very similar to that of the rabbit gene that codes for the biochemically related uteroglobin protein...
  96. ncbi Monkey Clara cell 10 kDa protein (CC10): a characterization of the amino acid sequence with an evolutional comparison with humans, rabbits, rats, and mice
    S Hashimoto
    First Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Am J Respir Cell Mol Biol 15:361-6. 1996
    ..6%, 52.9%, 52.9%, and 44.3% with human CC10, rat CC10 (PCB binding protein), rabbit uteroglobin, and mouse CC10, respectively...
  97. ncbi Human uteroglobin gene: structure, subchromosomal localization, and polymorphism
    Z Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA
    DNA Cell Biol 16:73-83. 1997
    Human uteroglobin (hUG) or Clara cell 10-kD protein (cc10 kDa) is a steroid-dependent, immunomodulatory, cytokine-like protein. It is secreted by mucosal epithelial cells of all vertebrates studied...
  98. ncbi Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences 1 757, Asahimachi Dori, Niigata, 951 8510, Japan
    Kidney Int 61:1853-8. 2002
    b>Uteroglobin is a multifunctional protein and both its gene knockout and antisense transgenic mouse models develop the pathological and clinical features of IgA nephropathy...
  99. ncbi Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma
    Jae Ho Han
    Department of Pathology, Ajou University School of Medicine, Suwon, Korea
    Arch Pathol Lab Med 127:1330-4. 2003
    ..Mammaglobin, a mammary-specific member of the uteroglobin family, is known to be overexpressed in human breast cancer.
  100. pmc Isolation and structure of the gene for the progesterone-inducible protein uteroglobin
    C Menne
    Proc Natl Acad Sci U S A 79:4853-7. 1982
    b>Uteroglobin is a small steroid-binding protein that is differentially regulated by steroid hormones in several tissues of the rabbit...
  101. ncbi Determinants of serum levels of surfactant proteins A and B and Clara cell protein CC16
    Cedric Hermans
    Industrial Toxicology and Occupational Medicine, Medical School, Universite Catholique de Louvain, Brussels, Belgium
    Biomarkers 8:461-71. 2003
    ..We conclude that CC16 is cleared from blood by the renal route, whereas SP-A and SP-B are not. Serum SP-A and SP-B are influenced by age, which we speculate reflects increased damage to the alveolocapillary barrier...

Research Grants47

  1. PROGESTERONE REGULATION OF GENE EXPRESSION
    Virginia Rider; Fiscal Year: 1993
    Transcription of the rabbit uteroglobin (UG) gene is regulated strongly by progesterone in the uterus, where estrogen has no (or little) effect, and weakly by glucocorticoids in the lung...
  2. MAMMAGLOBIN AND ITS ROLE IN HUMAN BREAST CANCER
    Timothy Fleming; Fiscal Year: 2000
    ..Mammaglobin is a member of the uteroglobin gene family which includes uteroglobin, Clara Cell 10 kD protein, mouse androgen binding protein, and ..
  3. INHIBITION OF CELLULAR SIGNALING
    David Strayer; Fiscal Year: 1999
    ..Mice to be used in these studies are 1) transgenic mice whose p32 expression is controlled by the powerful uteroglobin promoter, and 2) p32 knockout mice...
  4. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2007
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  6. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  7. Na, K-ATPase Regulation by Glucocorticoids in Lung
    Chris Wendt; Fiscal Year: 2007
    ....
  8. Role of IL-17 in Recruitment of Adult Stem Cells to Lung
    Daniel Weiss; Fiscal Year: 2006
    ..These studies will serve as a basis for more detailed investigations into mechanisms of recruitment and phenotypic conversion of adult marrow stem cells into airway epithelial cells. ..
  9. Prenatal Tobacco Smoke and Expression in Airways
    LAURA VAN WINKLE; Fiscal Year: 2006
    ..These studies will thus address the fetal basis of adult diseases of the lung caused by exposure in utero to environmental tobacco smoke. ..
  10. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  11. Stem Cells and Cellular Therapies in Lung Biology and Lung Diseases
    Daniel Weiss; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Gonadal vs. Genomic Influences on Xenobiotic Metabolism
    LAURA VAN WINKLE; Fiscal Year: 2008
    ..The proposed studies are relevant to diseases associated with pulmonary remodeling and PAH activation, such as lung cancer. ..
  13. Acquisition of LMD6000 Laser Microdissection Unit
    LAURA VAN WINKLE; Fiscal Year: 2008
    ..The overall benefits to the UC Davis campus are many. This equipment fits well with the research needs of the UC Davis community, which has included a recent emphasis on genomics. [unreadable] [unreadable] [unreadable]..
  14. Breast Cancer, Radiation and the ATM-CHEK2 Pathway
    Jonine Bernstein; Fiscal Year: 2008
    ..Conduct a population-based case-control association study of 6 genes involved in the ATM-CHEK2 pathway to determine whether they are associated with an increased risk of radiation-induced contralateral breast cancer. ..
  15. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010
    ..anthracis spores in mouse models as per the revised Specific Aims. All remaining Aims can be addressed in a two-year time period. PHS ..
  16. Hormonal and Genetic Influences in a Mouse Model of Sjogrens Syndrome
    Ana Maria Azzarolo; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Lung epithelial cell survival signaling in ozone in cystic fibrosis and normals
    Carl White; Fiscal Year: 2009
    ..These studies will increase our understanding of lung oxidant injury and repair in CF and normals, and of normal defense mechanisms of airway epithelium. ..
  18. Protein Biomarkers in Lung Allograft Rejection
    CHRIS H WENDT; Fiscal Year: 2010
    ..The second is to increase the number of biomarkers for chronic rejection, creating a panel of protein biomarkers that ultimately predicts those with or are at risk for chronic lung transplant rejection. ..
  19. Innate Immune Responses in Obliterative Bronchiolitis
    Scott Palmer; Fiscal Year: 2006
    ..He will apply these skills to direct future investigations of patient oriented research problems in pulmonary medicine...
  20. "Ligand Independent" endocrine disruption by pesticides
    Patrick Wong; Fiscal Year: 2005
    ..abstract_text> ..
  21. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2003
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  22. Biacore 3000 SPR Instrument
    Robert Lehrer; Fiscal Year: 2004
    ..These include the development of new agents and approaches to prevent and treat infections caused by HIV-1 and other viral pathogens, and fundamental issues related to cell targeting and survival. ..
  23. DEVELOPMENTAL SIGNAL INTEGRATION BY FETAL LUNG FIBROBLAS
    Matthew Lee; Fiscal Year: 2003
    ..By determining how Shc 66 regulates the growth of fibroblast precursors in the fetal and preterm neonatal lung, new strategies may be developed to attenuate the pathological fibroblast proliferation of BPD...
  24. CCSP IN INNATE DEFENSE AGAINST LUNG VIRAL INFECTION
    KEVIN HARROD; Fiscal Year: 2003
    ..This application will determine the role and delineate mechanisms by which CCSP provides innate immunity to viral infection in the lung. Such data may be useful in designing treatment and prevention of viral pneumonia. ..
  25. Novel Bisphosphonates for Breast Cancer Therapy
    MONICA REINHOLZ; Fiscal Year: 2002
    ..Proposed Commercial Application: Not Available. ..
  26. ROLE OF HEXOKINASE IN LUNG ADAPTATION TO OXIDANT STRESS
    Carl White; Fiscal Year: 2002
    ..Together, these approaches will define the role of HK in adaptation to hyperoxia. ..
  27. JSRV AND OVINE PULMONARY CARCINOMA
    James DeMartini; Fiscal Year: 2001
    ..All of these techniques have been done by the investigators involved. Similar studies, in some cases without the advantage of the newer techniques, have been used with success in other studies of retroviral-associated neoplasia. ..
  28. Interaction of Radiation, BRCA1/2, and Breast Cancer
    Jonine Bernstein; Fiscal Year: 2006
    ..Once our study has been completed, we will have established an outstanding resource for future studies of other putative breast cancer genes and environmental exposures, with a particular focus on radiation exposure. ..
  29. DEFENSINS--ANTIMICROBIAL PEPTIDES OF HUMAN NEUTROPHILS
    Robert Lehrer; Fiscal Year: 2002
    ..The work with murine neutrophils, whose content of endogenous antimicrobial polypeptides differs greatly from those of humans, will provide essential information relevant to the interpretation of murine models of human infection. ..
  30. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2001
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  31. TRANSFORMING GROWTH FACTOR ALPHA AND LUNG INJURY
    WILLIAM HARDIE; Fiscal Year: 2003
    ..The experiments proposed will permit the P.I. to develop an independent line of research in a division dedicated to understanding the basic pathobiology of various lung diseases. ..
  32. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2005
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  33. Recombinant CC10 for treatment of meconium aspiration
    Aprile Pilon; Fiscal Year: 2003
    ..CC10 is also known as clara cell secretory protein (CCSP) or uteroglobin and is produced primarily by tracheal and bronchial epithelia...
  34. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
    ..also shows strong homology to certain other steroid-binding and PLA2-inhibitory proteins (mammaglobin, uteroglobin and human CC-10) that are secreted by mammary, uterine, and lung epithelial cells...
  35. Development of Novel Bioprocess Platform for Rapid, Economical Production of Pept
    Aprile Pilon; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
    ..The opportunities provided by the training program will provide the foundation for career advancement and hopefully lead to new therapies for fibrotic lung diseases. ..
  37. Hypoxia-inducible factors bronchopulmonary dysplasia-BPD
    Carl White; Fiscal Year: 2006
    ..Therapy at the level of HIF transcription factors to improve angiogenesis and alveolar development offers promise to prevent BPD. ..
  38. Lung Transcriptional Regulation During Disease
    KEVIN HARROD; Fiscal Year: 2007
    ....
  39. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..abstract_text> ..
  40. DEVELOPMENTAL LUNG TOXICOLOGY & THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2009
    ..This work will further our understanding of the basic molecular mechanisms by which environmental insults are involved in the origins of lung diseases that begin in childhood. ..
  41. Airway Epithelial NF-kB Activation by CpG DNA
    Matthew Poynter; Fiscal Year: 2005
    ..Specific aim 4) Demonstrate that intranasal CpG DNA administration augments secretary immunoglobulin levels in the airway through TLR9-mediated NF-kB activation by bronchiolar epithelial cells. ..
  42. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  43. CCSP Promoter Function and Tumor Necrosis Factor
    KEVIN HARROD; Fiscal Year: 2006
    ..abstract_text> ..
  44. Pathophysiology of Mucus Hypersecretion in Asthma
    Christopher Evans; Fiscal Year: 2003
    ..The project proposed here utilizes expertise and reagents available in his laboratory applies them to an important problem in asthma. ..
  45. Novel Bisphosphonates for Multiple Myeloma Therapy
    MONICA REINHOLZ; Fiscal Year: 2004
    ..Successful development of this new drug-design concept would provide a biologically and commercially superior approach for the treatment and prevention of skeletal-related complications of malignancy. ..
  46. Mechanisms of Marrow-Derived Stem Cell Remodeling of Aged Emphysematous Lungs
    Daniel Weiss; Fiscal Year: 2008
    ..abstract_text> ..