Genomes and Genes
Summary: High molecular weight mucoproteins that form a protective biofilm on the surface of EPITHELIAL CELLS where they provide a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Publications385 found, 100 shown here
- Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionMaria Van Der Sluis
Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
Gastroenterology 131:117-29. 2006..Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel disease. Our aim was to obtain insight in the role of Muc2 in epithelial protection...
- The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaMalin E V Johansson
Department of Medical Biochemistry, University of Gothenburg, 405 30 Gothenburg, Sweden
Proc Natl Acad Sci U S A 105:15064-9. 2008..These findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation...
- Mucins in cancer: function, prognosis and therapyDonald W Kufe
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Cancer 9:874-85. 2009Epithelia are protected from adverse conditions by a mucous barrier. The secreted and transmembrane mucins that constitute the mucous barrier are largely unrecognized as effectors of carcinogenesis...
- Mucins in cancer: protection and control of the cell surfaceMichael A Hollingsworth
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
Nat Rev Cancer 4:45-60. 2004
- Intestinal goblet cells and mucins in health and disease: recent insights and progressYoung S Kim
Genemed Biotechnologies, 458 Carlton Court, South San Francisco, CA 94080, USA
Curr Gastroenterol Rep 12:319-30. 2010..cells synthesize secretory mucin glycoproteins (MUC2) and bioactive molecules such as epithelial membrane-bound mucins (MUC1, MUC3, MUC17), trefoil factor peptides (TFF), resistin-like molecule beta (RELMbeta), and Fc-gamma binding ..
- Colorectal cancer in mice genetically deficient in the mucin Muc2Anna Velcich
Department of Oncology, Albert Einstein Cancer Center Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA
Science 295:1726-9. 2002The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most ..
- Mucins in the mucosal barrier to infectionS K Linden
Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, Level 3 Aubigny Place, Mater Hospitals, South Brisbane, Queensland, Australia
Mucosal Immunol 1:183-97. 2008..Mucin glycoproteins are secreted in large quantities by mucosal epithelia, and cell surface mucins are a prominent feature of the apical glycocalyx of all mucosal epithelia...
- Composition and functional role of the mucus layers in the intestineMalin E V Johansson
Department Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden
Cell Mol Life Sci 68:3635-41. 2011..The progress in the last years in understanding the molecular nature of mucins, the main building blocks of mucus, has, however, changed this...
- Structure and function of the polymeric mucins in airways mucusDavid J Thornton
Wellcome Trust Center for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Annu Rev Physiol 70:459-86. 2008..In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUC5B, provide the organizing framework of the airways mucus gel ..
- Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitisChad K Heazlewood
Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and The University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
PLoS Med 5:e54. 2008..In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis...
- Mucins, mucus, and sputumJudith A Voynow
Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
Chest 135:505-12. 2009..The mucins are composed of two major families: secreted mucins and membrane-associated mucins...
- Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sitesKarin Julenius
Center for Biological Sequence Analysis, BioCentrum, Building 208, Technical University of Denmark, DK 2800 Lyngby, Denmark
Glycobiology 15:153-64. 2005..NetOGlyc 3.1 is made available at www.cbs.dtu.dk/services/netoglyc...
- Respiratory tract mucin genes and mucin glycoproteins in health and diseaseMary Callaghan Rose
Research Center for Genetic Medicine, Room 5700, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
Physiol Rev 86:245-78. 2006This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway health and disease. Mucins are highly glycosylated macromolecules (> or =50% carbohydrate, wt/wt)...
- Mucins and mucin binding proteins in colorectal cancerJames C Byrd
The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
Cancer Metastasis Rev 23:77-99. 2004b>Mucins are high-molecular weight epithelial glycoproteins with a high content of clustered oligosaccharides O-glycosidically linked to tandem repeat peptides rich in threonine, serine, and proline...
- Mucin 13: structure, function, and potential roles in cancer pathogenesisDiane M Maher
Cancer Biology Research Center, 2301 East 60th Street North, Sioux Falls, SD 57104, USA
Mol Cancer Res 9:531-7. 2011..MUC13 exhibits the characteristics suitable as an early marker for cancer screening and presents a promising target for antibody-guided targeted therapy...
- Trefoil factors: initiators of mucosal healingDouglas Taupin
The Canberra Hospital, Canberra, Australian Capital Territory, Australia
Nat Rev Mol Cell Biol 4:721-32. 2003..TFFs protect mucous epithelia from a range of insults and contribute to mucosal repair, although the signalling events that mediate these responses are only partially understood...
- Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteriaChin Wen Png
Mater Medical Research Institute and Department of Medicine, University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia
Am J Gastroenterol 105:2420-8. 2010..We hypothesized that mucolytic bacteria are increased in IBD, providing increased substrate to sustain nonmucolytic mucosa-associated bacteria...
- Intestinal trefoil factor confers colonic epithelial resistance to apoptosisD R Taupin
Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, 55 Fruit Street, GRJ 719, Boston, MA 02114 2696, USA
Proc Natl Acad Sci U S A 97:799-804. 2000..These findings support a central role for ITF in the maintenance of intestinal mucosal continuity, and conversely demonstrate the potential for ITF expression to confer resistance of colorectal tumors to therapy...
- The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cellsC Caballero-Franco
Institute of Parasitology, McGill University, Saint Anne de Bellevue, Quebec, Canada
Am J Physiol Gastrointest Liver Physiol 292:G315-22. 2007..These findings contribute to a better understanding of the complex and beneficial interaction between colonic epithelial cells and intestinal bacteria...
- Structure and function of the cell surface (tethered) mucinsChristine L Hattrup
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AR 85259, USA
Annu Rev Physiol 70:431-57. 2008Cell surface mucins are large transmembrane glycoproteins involved in diverse functions ranging from shielding the airway epithelium against pathogenic infection to regulating cellular signaling and transcription...
- Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFMB Logan Buck
Department of Food Science, North Carolina State University, Box 7624, Raleigh, NC 27695, USA
Appl Environ Microbiol 71:8344-51. 2005..This study demonstrated that multiple cell surface proteins in L. acidophilus NCFM can individually contribute to the organism's ability to attach to intestinal cells in vitro...
- Gel-forming mucins appeared early in metazoan evolutionTiange Lang
Department of Medical Biochemistry, Institute of Biomedicine, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
Proc Natl Acad Sci U S A 104:16209-14. 2007b>Mucins are proteins that cover and protect epithelial cells and are characterized by domains rich in proline, threonine, and serine that are heavily glycosylated (PTS or mucin domains)...
- Mucins in human neoplasms: clinical pathology, gene expression and diagnostic applicationSuguru Yonezawa
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Pathol Int 61:697-716. 2011b>Mucins are high molecular weight glycoproteins that play important roles in carcinogenesis and tumor invasion...
- Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tractCatherine Robbe
Unité Mixte de Recherche CNRS USTL 8576, Glycobiologie Structurale et Fonctionnelle, IFR 118, Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d Ascq cedex, France
Biochem J 384:307-16. 2004Purified human mucins from different parts of the intestinal tract (ileum, cecum, transverse and sigmoid colon and rectum) were isolated from two individuals with blood group ALe(b) (A-Lewis(b))...
- Mucin dynamics in intestinal bacterial infectionSara K Linden
Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
PLoS ONE 3:e3952. 2008..coli. Mucin glycoproteins are the main component of the first barrier that bacteria encounter in the intestinal tract...
- A new role for mucins in immunity: insights from gastrointestinal nematode infectionSumaira Z Hasnain
Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Health Services and the University of Queensland, Brisbane, QLD 4029, Australia
Int J Biochem Cell Biol 45:364-74. 2013..The framework of this barrier is provided by polymeric, gel-forming mucins. These enormous O-linked glycoproteins are synthesised, stored and secreted by goblet cells that are also the ..
- Expression analysis of highly polymorphic mucin proteins (Sm PoMuc) from the parasite Schistosoma mansoniEmmanuel Roger
Parasitologie Fonctionnelle et Evolutive, UMR 5244, CNRS Université de Perpignan, Perpignan Cedex, France
Mol Biochem Parasitol 157:217-27. 2008..Our data show that these proteins share structural characteristics with highly glycosylated secreted mucins. The proteins are (i) only expressed in larval stages that interact with the mollusc, (ii) located in the apical ..
- Mucins in inflammatory bowel diseases and colorectal cancerYong H Sheng
Immunity, Infection and Inflammation Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
J Gastroenterol Hepatol 27:28-38. 2012The gastrointestinal tract is protected by a mucus barrier with both secreted and cell-surface mucins contributing to the exclusion of luminal microbes and toxins...
- Microbial modulation of innate defense: goblet cells and the intestinal mucus layerB Deplancke
Department of Animal Sciences, University of Illinois at Urbana-Campaign, 61801, USA
Am J Clin Nutr 73:1131S-1141S. 2001..A precise definition of the regulatory networks that interface with goblet cells may have broad biomedical applications because mucus alterations appear to characterize most diseases of mucosal tissues...
- Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasisAjay P Singh
Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
Cancer Res 64:622-30. 2004....
- Role of intestinal mucins in innate host defense mechanisms against pathogensPoonam Dharmani
Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, Alta, Canada
J Innate Immun 1:123-35. 2009Gastrointestinal mucins produced by goblet cells comprise the main structural components of the mucus layer...
- Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gelMartin E Lidell
Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, S 413 90 Gothenburg, Sweden
Proc Natl Acad Sci U S A 103:9298-303. 2006..Heavily O-glycosylated and protease-resistant mucin domains characterize gel-forming mucins. Their N- and C-terminal cysteine-rich domains are involved in mucin polymerization, and these domains are likely ..
- Trypanosoma cruzi surface mucins: host-dependent coat diversityCarlos A Buscaglia
Instituto de Investigaciones Biotecnologicas Instituto Tecnologico de Chascomus IIB INTECH, Universidad Nacional de General San Martn CONICET, San Martin 1650, Buenos Aires, Argentina
Nat Rev Microbiol 4:229-36. 2006The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which contribute to parasite protection and to the establishment of a persistent infection...
- Mucins and inflammatory bowel diseaseT Shirazi
University of Bristol, Bristol Royal Infirmary University Department of Medicine, UK
Postgrad Med J 76:473-8. 2000..The mucins that make up this layer consist of a protein backbone with oligosaccharides attached to specific areas of the ..
- Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epitheliumMitsuko Kondo
First Department of Medicine, Tokyo Women s Medical University, School of Medicine, Japan
Am J Respir Cell Mol Biol 27:536-41. 2002..These data suggest that human recombinant IL-13, but not IL-4, can induce differentiation into mature goblet cells that produce MUC5AC protein in guinea pig tracheal epithelial cells in vitro...
- Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9Mariko Ohta
Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kita ku, Kyoto, Japan
Biochem Biophys Res Commun 402:663-9. 2010..In the present study, we investigated whether or not the ligation of tumor-produced mucins with Siglec-9 expressed on immature DCs is related to escape from immunosurveillance in the tumor-bearing state...
- New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7K Rousseau
Galton Laboratory, Department of Biology, University College London, United Kingdom
Hybrid Hybridomics 22:293-9. 2003The separation and characterization of salivary mucins is not straightforward because of their large size, heterogeneity, and molecular interactions...
- Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapyPartha Mukhopadhyay
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Biochim Biophys Acta 1815:224-40. 2011b>Mucins are high molecular weight, multifunctional glycoproteins comprised of two structural classes-the large transmembrane mucins and the gel-forming or secreted mucins...
- Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasiteM Eugenia Giorgi
CIHIDECAR, Departamento de Quimica Organica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, 1428 Buenos Aires, Argentina
Carbohydr Res 346:1389-93. 2011..a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host glycoconjugates to mucins of the parasite...
- Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4Jean Luc Desseyn
Unite 560 INSERM, Place de Verdun, 59045 Lille Cedex, France
Eur J Biochem 269:3150-9. 2002..Based on these data, we concluded that we isolated the mouse ortholog of MUC4 we propose as Muc4. Expression studies showed that Muc4 is ubiquitous like SMC and MUC4, with highest levels of expression in trachea and intestinal tract...
- Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndromeBojing Shao
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Blood 118:4015-23. 2011..Injecting carcinoma mucins into mice generates platelet-rich microthrombi dependent on P- and L-selectin but not thrombin...
- Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distributionHenrik Nordman
Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
Biochem J 364:191-200. 2002Gastric MUC5AC and MUC6 mucins were studied using polyclonal antibodies. Immunohistochemistry showed MUC5AC to originate from the surface epithelium, whereas MUC6 was produced by the glands...
- Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene familyJ L Desseyn
INSERM 377 Laboratoire Gérard Biserte, Place de Verdun, 59045 Lille Cedex, France
J Biol Chem 272:3168-78. 1997..The super-repeat present in MUC5B is the largest ever determined in mucin genes and the central exon of this gene is, by far, the largest reported for a vertebrate gene...
- Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elementsHays W J Young
Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 37:273-90. 2007Mucus hypersecretion contributes to morbidity and mortality in many obstructive lung diseases. Gel-forming mucins are the chief glycoprotein components of airway mucus, and elevated expression of these during mucous metaplasia precedes ..
- Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitroD R Mack
Department of Pediatrics, University of Ottawa, Canada
Gut 52:827-33. 2003b>Mucins are large complex glycoproteins that protect intestinal mucosal surfaces by limiting access of environmental matter to their epithelial cells...
- Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrierPABLO ARGUESO
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
J Biol Chem 284:23037-45. 2009..of defense has been the subject of much investigation, and there is evidence now implicating O-glycosylated mucins on the epithelial cell surface...
- Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cellsMatt X G Shao
Cardiovascular Research Institute and Departments of Medicine and Physiology, University of California, San Francisco, CA 94143 0130, USA
Proc Natl Acad Sci U S A 100:11618-23. 2003..From these results, we conclude that TACE plays a critical role in mucin production by airway epithelial cells by means of a TACE ligand-EGFR cascade in response to various stimuli...
- Comparison of in vitro models to study bacterial adhesion to the intestinal epitheliumJ M Laparra
Institute of Agrochemistry and Food Technology, Burjassot, Valencia, Spain
Lett Appl Microbiol 49:695-701. 2009..To evaluate the adhesion ability of intestinal bacteria to different in vitro models of intestinal epithelia, and to estimate the suitability of these models and the type of interactions involved...
- Current status of mucins in the diagnosis and therapy of cancerSatyanarayana Rachagani
Department of Biochemistry and Molecular Biology, Department of Pathology and Microbiology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
Biofactors 35:509-27. 2009b>Mucins are the most abundant high molecular weight glycoproteins in mucus...
- Fusobacterium nucleatum infection of colonic cells stimulates MUC2 mucin and tumor necrosis factor alphaPoonam Dharmani
Gastrointestinal Research Group, Health Sciences Centre, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta T2N 4N1, Canada
Infect Immun 79:2597-607. 2011..nucleatum may represent a challenging pathogen in the etiology of gut inflammatory diseases and highlight the importance of different pathotypes of candidate bacterial species in disease pathogenesis...
- The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomesMark W J van Passel
Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
PLoS ONE 6:e16876. 2011..This anaerobic resident is associated with the protective mucus lining of the intestines...
- Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancerAjay P Singh
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Lancet Oncol 9:1076-85. 2008Knowledge of mucins and their multiple roles in various normal and pathological processes has improved greatly in the past two decades...
- The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragmentKlaus Godl
Department of Medical Biochemistry, Goteborg University, Gothenburg, Sweden
J Biol Chem 277:47248-56. 2002....
- Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cellsSandra Pinho
Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias, s n 4200 465 Porto, Portugal
Cancer Lett 249:157-70. 2007..Sialyl-Tn antigen is able to modulate a malignant phenotype inducing a more aggressive cell behavior, such as decreased cell-cell aggregation and increased ECM adhesion, migration and invasion...
- MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cellsPallavi Chaturvedi
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
Cancer Res 68:2065-70. 2008..Our findings add a new dimension to MUC4 function as a modulator of cell signaling and provide mechanistic evidence for its role in pancreatic cancer progression...
- Architecture of the large membrane-bound mucinsJean Luc Desseyn
INSERM U837 JPARC, 59045 Lille, France
Gene 410:215-22. 2008Epithelial membrane-bound mucins are high molecular mass glycoproteins that may be also secreted or released into the extracellular environment...
- MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbationMarkus O Henke
Philipps University Marburg, Department of Pulmonary Medicine, Baldingerstrasse 1, 35043 Marburg, Germany
Am J Respir Crit Care Med 175:816-21. 2007Cystic fibrosis (CF) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions...
- The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancersNicolas Jonckheere
INSERM, Jean Pierre Aubert Research Centre, Lille, France
Biochimie 92:1-11. 2010The membrane-bound mucins belong to an ever-increasing family of O-glycoproteins...
- MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicatorsH S Lee
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
Cancer 92:1427-34. 2001..between clinicopathologic profiles and the patients' survival, the expression of MUC1, MUC2, MUC5AC, MUC6 mucins and the p53 protein were evaluated immunohistochemically in 300 consecutive gastric carcinomas using the tissue-..
- Pathogenesis of carcinoma of the papilla of VaterHans Peter Fischer
Department of Pathology, University of Bonn, Sigmund Freud Str 25, D 53127, Bonn, Germany
J Hepatobiliary Pancreat Surg 11:301-9. 2004..Consequently, the histologic classification should reflect the histogenesis of ampullary tumors from the two different types of papillary mucosa...
- Diagnostic ions for the rapid analysis by nano-electrospray ionization quadrupole time-of-flight mass spectrometry of O-glycans from human mucinsCatherine Robbe
Unité Mixte de Recherche CNRS USTL 8576, Glycobiologie Structurale et Fonctionnelle, IFR 118, Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d Ascq cedex, France
Rapid Commun Mass Spectrom 18:412-20. 2004..was used for sensitive mapping and sequencing of underivatized oligosaccharide alditols obtained from human mucins. Using subnanomolar amounts of oligosaccharides previously analyzed by nuclear magnetic resonance (NMR), series of ..
- The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cellsIna Leverkoehne
Department of Pathology, School of Veterinary Medicine Hannover, Hannover, Germany
J Histochem Cytochem 50:829-38. 2002..The results suggest that mCLCA3 may be involved in the synthesis, condensation, or secretion of mucins.
- Inhibition of Escherichia coli O157:H7 attachment by interactions between lactic acid bacteria and intestinal epithelial cellsYounghoon Kim
Department of Animal Science, Institute of Agricultural Science and Technology, Chonnam National University, Gwangju, Korea
J Microbiol Biotechnol 18:1278-85. 2008..Intestinal tract mucins are principal components of the mucus layer on epithelial surfaces, and perform a protective function against ..
- Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut modelPieter Van den Abbeele
Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Ghent, Belgium
ISME J 7:949-61. 2013..butyrate producers within this cluster, Roseburia intestinalis and Eubacterium rectale most specifically colonized mucins. These 16S rRNA gene-based results were confirmed at a functional level as butyryl-CoA:acetate-CoA transferase ..
- The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectinPilar Alcaide
Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, 28049 Spain
Int Immunol 16:1365-75. 2004..Our results suggest that Ag C10, through binding to L-selectin, was able to inhibit different activation pathways that lead to inhibition of IL-2 secretion and T cell proliferation. This was independent of NO and IFN-gamma...
- Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptorK Kohri
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
Eur Respir J 20:1263-70. 2002..The authors conclude that PA products induce mucin MUC5AC production in human airway epithelial cells via the expression and activation of epidermal growth factor receptor...
- O-glycosylation of the mucin typeF G Hanisch
Institute of Biochemistry, Medical Faculty of the University, , Germany
Biol Chem 382:143-9. 2001....
- Structure and biological roles of mucin-type O-glycans at the ocular surfaceAna Guzman-Aranguez
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
Ocul Surf 8:8-17. 2010b>Mucins are major components in mucus secretions and apical cell membranes on wet-surfaced epithelia...
- Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemiaShu Q Liu
Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208 3107, USA
Am J Physiol Heart Circ Physiol 303:H1446-58. 2012..These observations suggest that the liver contributes to cardioprotection in MI by upregulating and releasing protective secretory proteins. These proteins may be used for the development of cardioprotective agents...
- Mucin production during prenatal and postnatal murine lung developmentMichelle G Roy
Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 44:755-60. 2011..To identify potential roles for secreted gel--forming mucins in lung development, we isolated murine lungs on embryonic days (E) 12.5-18...
- Exploring the transcriptome of Atlantic salmon (Salmo salar) skin, a major defense organGiulia Micallef
Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
Mar Biotechnol (NY) 14:559-69. 2012..Several isotigs exhibited homology to mammalian mucins (MUC2, MUC5AC and MUC5B)...
- The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucinsAngelina S Palma
Glycosciences Laboratory, Department of Medicine, Imperial College London, Northwick Park and St Marks Campus, Watford Road, Harrow, Middlesex, UK
Biochem Biophys Res Commun 408:548-52. 2011....
- Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environmentJoan Vermeiren
Laboratory of Microbial Ecology and Technology, Ghent University, Gent, Belgium
FEMS Microbiol Ecol 79:685-96. 2012..The M-SHIME model revealed depletion in butyrate producing microbial communities not restricted to the luminal but also in the mucosal samples from UC patients compared to HV...
- Expression of MUC5AC in colorectal carcinoma and relationship with prognosisBelma Kocer
Department of Second General Surgery, Ankara Numune Teaching and Research Hospital, Ankara, Turkey
Pathol Int 52:470-7. 2002Overexpression and alterations in the glycosylation of gastric mucins have been described in colorectal carcinoma...
- Recent insights into the biological roles of mucin-type O-glycosylationE Tian
Developmental Glycobiology Unit, NIDCR, National Institutes of Health, Building 30, Room 426, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
Glycoconj J 26:325-34. 2009..Gaining an understanding of mucin-type O-glycans in these diverse systems will elucidate crucial conserved processes underlying many aspects of development and homeostasis...
- Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residuesRodrigo P Soares
Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
Am J Trop Med Hyg 87:87-96. 2012The glycosylphosphatidylinositol (GPI)-anchored mucins of Trypanosoma cruzi trypomastigotes play an important immunomodulatory role during the course of Chagas disease. Here, some biological activities of tGPI-mucins from four T...
- Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected miceJames G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Am J Pathol 171:1520-8. 2007..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach...
- A morphometric study of mucins and small airway plugging in cystic fibrosisPierre Regis Burgel
Service de Pneumologie, Hopital Cochin, Universite Rene Descartes, 27 rue du Faubourg St Jacques, 75 679 Paris Cedex 14, France
Thorax 62:153-61. 2007..Little knowledge exists on structural changes and plugging in small airways in cystic fibrosis...
- IFN-gamma-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma responseM Andrianifahanana
Department of Biochemistry and Molecular Biology, The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
Oncogene 26:7251-61. 2007..In conclusion, our findings identify a novel mechanism for MUC4 regulation in pancreatic cancer cells and unfold new perspectives on the foundation of IFN-gamma-dependent gene regulation...
- Structural organization and classification of the human mucin genesN Moniaux
Unite 377 INSERM, Place de Verdun, 59045 Lille Cedex and Laboratoire de Biochimie et de Biologie Moleculaire de l'Hopital C. Huriez, 59037 Lille Cedex, France
Front Biosci 6:D1192-206. 2001..With evolution, defense mechanisms, such as the secretion of mucus has been developed. Mucins are the main components of mucus...
- TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injuryJames J Farrell
Massachusetts General Hospital, Gastrointestinal Unit, Boston, Massachusetts, USA
J Clin Invest 109:193-204. 2002..Taken together, these results suggest a physiologic role for TFF2 to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion...
- Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseasesP R Burgel
Service de Pneumologie and UPRES EA 2511, Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Eur Respir J 32:1068-81. 2008..In considering each therapeutic intervention, the potential benefits must be considered in relation to potential deleterious effects...
- Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeastNadia Vadaie
Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
J Cell Biol 181:1073-81. 2008Signaling mucins are cell adhesion molecules that activate RAS/RHO guanosine triphosphatases and their effector mitogen-activated protein kinase (MAPK) pathways...
- Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucoseE Gaudier
Human Nutrition and Gut Function Department, Institut National de la Recherche Agronomique, Nantes, France
Am J Physiol Gastrointest Liver Physiol 287:G1168-74. 2004..It is mainly composed of high molecular weight glycoproteins called mucins. Butyrate, a short-chain fatty acid produced during carbohydrate fermentation, has been shown to increase mucin ..
- Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cellsYong Dae Kim
Department of Otorhinolaryngology, College of Medicine, Yeungnam University, Nam Gu, Daegu, South Korea
Mol Pharmacol 62:1112-8. 2002..These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production...
- MUC1 and MUC2 in pancreatic neoplasiaE Levi
John Dingell Veterans Administration Medical Center, 4646 John Road, Detroit, MI 48201, USA
J Clin Pathol 57:456-62. 2004..Thus, in pancreatic neoplasia, MUC1 and MUC2 have potential diagnostic and prognostic value as markers of aggressive and indolent phenotypes, respectively, and have potential as therapeutic targets...
- Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to surviveKermit L Carraway
Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA
Prog Nucleic Acid Res Mol Biol 71:149-85. 2002..The soluble form facilitates the protection and lubrication of epithelia by mucous gels composed of gel-forming mucins, as in the airway, where Muc4 is proposed to participate in mucociliary transport as a constituent of the ..
- Structure and biosynthesis of human salivary mucinsA Zalewska
Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland
Acta Biochim Pol 47:1067-79. 2000Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa...
- Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factorJ R Gum
Gastrointestinal Research Laboratory 151M2, Department of Veterans Affairs Medical Center, San Francisco, California
J Biol Chem 269:2440-6. 1994Secretory mucins consist of a protein backbone that is catenated by disulfide bonds, heavily O-glycosylated, and packaged into storage granules prior to release from cells...
- The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive regionJ R Gum
Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, California
J Biol Chem 267:21375-83. 1992..This latter subdomain exhibits varying degrees of sequence similarity to a wide range of mucins and mucin-like proteins including those isolated from rats, pigs, cows, and frogs...
- The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cellsThomas E Grys
Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 1300 University Ave, Room 481 MSC, Madison, WI 53706, USA
Infect Immun 73:1295-303. 2005..Thus, StcE may help block host clearance of E. coli O157:H7 by destruction of some classes of glycoproteins, and it contributes to intimate adherence of E. coli O157:H7 to the HEp-2 cell surface...
- Two atypical enteropathogenic Escherichia coli strains induce the production of secreted and membrane-bound mucins to benefit their own growth at the apical surface of human mucin-secreting intestinal HT29-MTX cellsMonica A M Vieira
INSERM, UMR756 Signalisation et Physiopathologie des Cellules Epithéliales, Chatenay Malabry Cedex, France
Infect Immun 78:927-38. 2010..we demonstrate that apically aEPEC infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins...
- Hath1 up-regulates gastric mucin gene expression in gastric cellsAkiko Sekine
Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Biochem Biophys Res Commun 344:1166-71. 2006..These data indicate that Hath1 is one of the transcriptional regulators for MUC6 and MUC5AC in GC cells. It is also possible that loss of Hath1 expression may play a role in gastric carcinogenesis...
- Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatmentJessica A Clark
Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5073, USA
Am J Physiol Gastrointest Liver Physiol 291:G938-49. 2006..EGF treatment maintains intestinal integrity at the site of injury by accelerating goblet cell maturation and mucin production and normalizing expression of TJ proteins, leading to improved intestinal barrier function...
- Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agentsJian Ren
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 5:163-75. 2004..These findings indicate that MUC1 attenuates the apoptotic response to DNA damage and that this oncoprotein confers resistance to genotoxic anticancer agents...
- Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasmsBrian B Haab
Van Andel Research Institute, Grand Rapids, MI, USA
Ann Surg 251:937-45. 2010..Here we explored whether glycosylation variants on specific proteins in cyst fluid samples could serve as biomarkers to aid in this diagnosis...
- Trefoil peptides: from structure to functionL Thim
Department of Protein Chemistry, Novo Nordisk A S, Bagsvaerd, Denmark
Cell Mol Life Sci 53:888-903. 1997..This review summarises our present knowledge of trefoil peptide structures, their sites of expression, and their protection and repair functions, with a focus on the mechanism by which these peptides exert their biological function...
- Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairsN Porchet
Unité 16 INSERM, Lille, France
Biochem Biophys Res Commun 175:414-22. 1991..with a polyclonal antiserum raised to chemically deglycosylated pronase glycopeptides from human bronchial mucins. Out of 20 positives clones, one partial cDNA clone was isolated and allowed to map a novel human tracheo-..
- Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiencyDaniel K Podolsky
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
Gastroenterology 137:209-20. 2009..The aim of this study was to determine whether Toll-like receptor (TLR) 2 and modulation of GC-derived trefoil factor (TFF) 3 are functionally linked in the intestine...
- Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humansNicolas Moniaux
Department of Biochemistry and Molecular Biology and Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
J Histochem Cytochem 52:253-61. 2004..Anti-MUC4 MAb may represent a powerful tool for the study of MUC4 function under normal and pathological conditions and for diagnosis of solid tumors including those in the breast, pancreas, lungs, and ovaries...
- The MUC2 gene product: a human intestinal mucinA Allen
Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, UK
Int J Biochem Cell Biol 30:797-801. 1998..The MUC2 product is polymerised end to end through disulphide bridges to form large secreted polymeric gel-forming mucins (Mr approximately 10(7))...
- BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINSPi Wan Cheng; Fiscal Year: 2010..Secreted from goblet cells on the surface epithelium and mucus cells in the submucosal glands, mucins not only are the major determinant of the viscoelastic properties of mucus secretion but also can serve as the ..
- Nanoparticle Coupled Antioxidants for Respiratory Illness in VeteransRODNEY JON SCHLOSSER; Fiscal Year: 2013..We will use a murine model of allergic fungal rhinosinusitis with exacerbation by smoke or DEP exposure to determine the efficacy of antiMUC1-SOD/CAT-NPs. ..
- Regulation of Airway Mucin Gene Expression by Epigenetic MechanismReen Wu; Fiscal Year: 2013DESCRIPTION (provided by applicant): Mucins are major contributors to the visco-elastic properties of mucus secretion, which plays an important role in the mucociliary clearance in conducting airways...
- Pilot Studies of the Effect of Aging on Mucociliary ClearanceLawrence E Ostrowski; Fiscal Year: 2013..The ion transport properties of the upper and lower airways wil be determined, as these are reflective of the hydration status of the ASL. Tissue samples from mice 3, 6, 12, and 24 months old will be studied in Ussing chambers. ..
- ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMAKwang Chul Kim; Fiscal Year: 2010..In this project, we will try to understand the mechanism at the cellular and molecular level. Successful completion of this project will shed valuable insights in our understanding of the development of asthma. ..
- Mouse models for esophageal Cox-2 oxidative stress and DNA damageJohn P Lynch; Fiscal Year: 2013....
- Counter-Regulation of TLR-Driven Mucosal InflammationErik P Lillehoj; Fiscal Year: 2010..Successful accomplishment of this project will provide pharmacological strategies to control excessive inflammation during airway bacterial colonization of mucosal surfaces. ..
- Mechanisms of oxidant-induced chronic bronchitisROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012....
- Nanotheranostics for Early Colorectal Cancer Detection and TreatmentJeffrey S Souris; Fiscal Year: 2013..with lectins/aptamers/peptides that target M-T stage-dependent, aberrant polyp glycan/glycoprotein expression (mucins MUC1 and MUC15, mucin-like tumor-associated glycoprotein TAG-72, and mucin surface glycan [unreadable]-L-fucose)...
- The Role of Beta-Gal Mediated Interactions in Prostate Cancer MetastasisVLADISLAV V GLINSKII; Fiscal Year: 2013..abstract_text> ..
- Modeling oxidative stress and DNA damage using GI organotypic culture systemsJohn P Lynch; Fiscal Year: 2013..It will also foster the development of novel therapeutic and preventive strategies that will improve patient care for these important clinical conditions. ..
- H. influenzae: Role of Sialic Acid in VirulenceMichael A Apicella; Fiscal Year: 2013..Finally, studies of isolates from human subjects colonized with NTHi 2019strR will examine the role of phase variation on LOS structure and determine if foreign DNA is acquired by NTHi during colonization. ..
- Oral Mucins as a Diagnostic Indicator and Therapeutic Treatment for XerostomiaDAVID JOHN CULP; Fiscal Year: 2011DESCRIPTION (provided by applicant): Mucins are a primary component of mucus covering those parts of the body exposed to the environment, including the airways, digestive tract, urogenital system, and the oral cavity...
- Probiotics and HIF signaling in Alcoholic Liver DiseaseWenke Feng; Fiscal Year: 2013..Protection of the mucus layer involves mucins and a number of regulatory peptides, such as intestinal trefoil factors (ITFs), which play critical rols in ..
- IL8-induced Post-transcriptional Regulation of the MUC5AC mucin geneMary C Rose; Fiscal Year: 2010..b>Mucins are hypersecreted and overproduced in lung diseases, thereby contributing to airway mucus obstruction and to ..
- H. influenzae: Role of Sialic Acid in VirulenceMichael Apicella; Fiscal Year: 2009..abstract_text> ..
- Effect of Helicobacter pylori cell shape on pathogenesisLAURA ELIZABETH MARTINEZ; Fiscal Year: 2013..We will also investigate the mechanisms by which PG recycling mutants cause elevated pro-inflammatory cytokine release (aim 3B). ..
- Alcohol and Breast CancerJia Luo; Fiscal Year: 2012..Understanding the interactions among alcohol, ErbB2 and MUC1 will also provide an important insight into the pathogenesis of some human diseases related to alcohol abuse as well as alcohol's teratogenic effect during development. ..
- Sulfotransferases in the Synthesis of L-Selectin LigandsSteven D Rosen; Fiscal Year: 2010..To evaluate this hypothesis, we will determine whether isolated airway mucins can activate neutrophils through binding to L-selectin and cause the secretion of broncho-active substances...
- Bile Acids, Genetic Control and Colonic Function in Irritable Bowel SyndromeMICHAEL L CAMILLERI; Fiscal Year: 2013....
- Role of mucin-type O-glycosylation in Trypanosoma cruzi biologyChristopher M West; Fiscal Year: 2012..of mucin-type glycoproteins include the sugar 1GlcNAc forming the bridge between O-glycans and Thr residues of the mucins, 2Gal residues found both in the pyranosidic and/or furanosidic forms, and terminal 13Gal or sialic-acid residues, ..
- Development of Therapeutic Pan-Filovirus Macaque Monoclonal AntibodiesSven G Enterlein; Fiscal Year: 2013..Upon successful completion of this Phase I SBIR we envision a Phase II focused on demonstration of protective efficacy in NHP models and standard pre-clinical development activities in preparation for regulatory filing. ..
- Glycosyltransferase Golgi Retention MechanismPi Wan Cheng; Fiscal Year: 2013..glycoproteins and C2GnT-M synthesizes all three branch structures, core 2, core 4, and I antigen, in secreted mucins while the function of C2GnT-3 is unknown...
- Oligosaccharide moieties of human milk glycans that inhibit pathogensDavid S Newburg; Fiscal Year: 2013..Glycans, including glycoproteins, glycolipids, mucins, and glycosaminoglycans, contain complex oligosaccharide structures attached to proteins, lipids, and other ..
- Development of an Anti-PSGL-1 Antibody to Treat Crohn's DiseaseScott A Rollins; Fiscal Year: 2011..S. The drug being developed addresses a major unmet medical need for a therapy that can maintain remission and/or ameliorate the devastating effects of this disease. ..
- Oxyntic Atrophy and Novel Gastric LineagesJAMES RICHARD GOLDENRING; Fiscal Year: 2013..mucosa is assembled from a heterogeneous group of epithelial lineages responsible for the normal secretion of mucins, pepsinogen and HCl. Chronic injury associated with H...
- Impact of Inflammatory Genes on Glandular Hyperplasia in Children with SinusitisMary C Rose; Fiscal Year: 2010....
- CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUMJoseph E Kerschner; Fiscal Year: 2013..Specifically, gel-forming mucins (GFM), produced by middle ear mucosa (MEM), are known to be the primary cause of hearing loss which develops in ..
- Trafficking mechanisms for secretory vesicles in pancreatic duct epithelial cellsDuk Su Koh; Fiscal Year: 2013..The experiments are broadly relevant to treatment of disorders of the digestive system. ..
- Control of Mucin Glycan Branching in Membrane-bound and Secreted MucinsPi Wan Cheng; Fiscal Year: 2010..They are found primarily in secreted mucins and membrane-bound glycoproteins, including some mucins...
- Airway Epithelial Responses to Allergic InflammationDavid J Erle; Fiscal Year: 2010..Asthma is a major public health problem that affects tens of millions of Americans and this work will help to identify and assess several potential new targets for asthma treatment. ..
- TIM Family of Genes: Role in T Cell Immunity and ToleranceVijay K Kuchroo; Fiscal Year: 2012..abstract_text> ..
- Regulation of Vibrio cholerae motility, stress response and detachment from intesANISIA J SILVA-BENITEZ; Fiscal Year: 2013..As an in vitro model we will use HT29-18N2 cultured cells which can be induced to differentiate into mucin-secreting goblet cells. As an in vivo model we will use adult rabbit ileal loops. ..
- Development of a novel second-generation pan-filovirus subunit vaccineKelly Lyn Warfield; Fiscal Year: 2012..In this proposal, using a novel approach, we seek to develop a vaccine that is easy to produce and would protect against several strains of filoviruses. ..
- Bacteria-Mucin Interactions at the Ocular SurfaceIlene K Gipson; Fiscal Year: 2012..in the absence of known or suspected ocular surface trauma), interact with and affect membrane-associated mucins to gain access to epithelial cells...
- Molecular Pathways Regulating Airway Goblet Cell Mucin SecretionBurton F Dickey; Fiscal Year: 2013DESCRIPTION (provided by applicant): The secreted gel-forming mucins of the airway provide important protective functions through the clearance of inhaled pathogens and particulates;however, mucin hypersecretion causes airflow ..
- Novel Molecules in Airway Epithelial Endoplasmic ReticulumBradley W Schroeder; Fiscal Year: 2012..David Erle. Excessive amounts of mucins, enormous glycoproteins that appear to be critical for the viscoelastic properties of mucus, contribute to ..
- Tim3 and Mycobacterium tuberculosisSamuel M Behar; Fiscal Year: 2013..Does IL-1 and its downstream mediators activate human MX to kill Mtb? 7 Aim 3. How does the Tim3/Gal9 interaction modulate immunity to tuberculosis in vivo? ..
- Virulence in Enteroaggregative Escherichia coliJames P Nataro; Fiscal Year: 2013..In this project, we will further characterize the mechanisms of EAEC- induced diarrhea with an eye toward development of effective preventive measures. ..
- Effects of saliva on herpes simplex virus infection of oralcellsCLAUDE F KRUMMENACHER; Fiscal Year: 2013..data showing that jacalin depletes saliva of its activity suggest a role for carbohydrates on glycoproteins, mucins and/or IgA. Thus we will examine the role of carbohydrates and use this lectin to improve purification...
- Oxidative stress in asthma initiationSanjiv Sur; Fiscal Year: 2010..Future studies of POPAC may identify novel therapeutic approaches in asthma. ..
- Dual Oxidase in Airway Epithelial Injury and InflammationAlbert van Der Vliet; Fiscal Year: 2013..Successful accomplishment of these studies would identify DUOX1 as a novel and attractive therapeutic target in the management of asthma and/or its exacerbations. ..
- Modulation of MUC1 Mucin TraffickingRebecca P Hughey; Fiscal Year: 2010..Our success in these studies will provide novel and fundamental insights into both MUC1-dependent signaling and mislocalization in tumors, which will contribute to a new level of understanding of MUC1 biology in human cancer. ..
- Interactions of Ebola virus glycoproteins with host cellsPaul Bates; Fiscal Year: 2013....
- Regulation of TH2 memory/effector cells during allergic inflammationYui Hsi Wang; Fiscal Year: 2013....
- Carbohydrate Antigenic Biomarkers for Epithelial CancersMinoru Fukuda; Fiscal Year: 2013..using glycan arrays generated from the prostate cancer cell line, PC-3, and from AE3 antigen-positive epithelial mucins. The second is cell transfection of specific glycosyltransferases and other glyco-modifying enzymes such as ..
- Serum biomarkers for early detection of H. pylori-associated gastric cancerJay V Solnick; Fiscal Year: 2013..abstract_text> ..
- Conjunctival Goblet Cell NLRP3 Inflammasome in Ocular Surface Bacterial InfectionDarlene A Dartt; Fiscal Year: 2013..Agonists, antagonists, chemical inhibitors, and siRNA will be used to characterize responses. ..
- Development of human thioredoxin as a mucolytic therapy for Cystic FibrosisPeter B Heifetz; Fiscal Year: 2012..This mucus barrier is composed primarily of cross-linked chains of proteins (mucins) complexed with nucleic acids released as a consequence of persistent lung inflammation and infection...
- Molecular Markers for the Diagnosis of Pancreatic CancerSurinder K Batra; Fiscal Year: 2012..The proposed investigations are expected to improve the current diagnosis of pancreatic cancer and can easily be translated to clinics after successful multi-center evaluation. ..
- Regulation of NF-kappaB and IKK by proinflammatory stimuliMichael Karin; Fiscal Year: 2013..The proposed studies will be based on a combination of biochemistry, cell biology, and mouse physiology, an integrated approach that was proven very effective in the past. ..
- FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTIONGordon C Douglas; Fiscal Year: 2013..Aim 4 determines whether MUC1 modulates ER function by regulating the intracellular localization of ERs. The final aim uses an optical trap to determine whether cell surface MUC1 responds to directly applied force. ..
- The Role of MAP 3 kinase 1 in Ocular Surface MorphogenesisYing Xia; Fiscal Year: 2012..Information derived from this work will pave the way for further investigation of genetic and environmental interactions in ocular surface development and identification of the etiology of congenital corneal anomalies. ..
- Preventing fucose-dependent binding of aspergillus and pseudomonas to lung mucinJohn V Fahy; Fiscal Year: 2012..In this way we will prevent microbial adhesion to mucins and mucin-covered cell surfaces, and we will inhibit the mucin cross-linking caused by these multimeric lectins...
- Pulmonary Formulation of tPA for Plastic BronchitisKathleen A Stringer; Fiscal Year: 2010..The information we acquire from this project is relevant to public health because it will improve the health and care of severely ill children. ..
- Modulation of conjunctival goblet cell differentiation by immunoregulatory cellsCintia Sade de Paiva; Fiscal Year: 2010..These studies will provide new information about natural mechanisms to control inflammation on the ocular surface and may provide new insight into treating ocular surface inflammatory diseases. ..
- MUCINS OF THE OCULAR SURFACEIlene K Gipson; Fiscal Year: 2013....
- The Pathobiology of Airway Disease in Alpha-1 Antitrypsin DeficiencyMichael A Campos; Fiscal Year: 2010..abstract_text> ..
- Functional Study of Mucin MUC1Sandra J Gendler; Fiscal Year: 2013..Results from these studies should give us clearer insight into the role of MUC1 in the epithelium and hematopoietic system in both inflammation and cancer signaling pathways. ..
- Up-regulation of Mucin Gene Transcription-Otitis MediaJian dong Li; Fiscal Year: 2013..Overall, these studies will unveil novel molecular mechanisms underlying mucin up-regulation and identify novel therapeutic targets, leading to new therapeutic strategy for inhibiting mucus overproduction in OM (significance). ..
- The Impact of Tobacco Exposure on the Lungs Innate Defense SystemRobert Tarran; Fiscal Year: 2013..Such knowledge may help dispel the myth that new tobacco products represent a safer alternative to cigarettes. ..
- Molecular mechanisms of squamous metaplasia in dry eyeNancy A McNamara; Fiscal Year: 2013..ocular surface to a keratinized, "skin-like" epithelium;and (2) disruption of ocular surface and goblet cell mucins. This process, known as squamous metaplasia (SQM), is a devastating, end-stage consequence of dry eye disease that ..
- Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01W Michael Foster; Fiscal Year: 2010..NQO1, generates reactive oxygen metabolites and leads to an increase in MUC5AC mRNA expression and production of mucins by airway epithelial cells...
- REGULATION OF GLANDULAR MUCOUS CELL SECRETIONDAVID CULP; Fiscal Year: 2001..b>Mucins are secreted in large part by mucous glands (e.g...
- DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELSTimothy Wiedmann; Fiscal Year: 2000..Moreover, elucidation of the limiting physical chemistry of lipids and mucin will form the basis for the structure/function of mucous membranes throughout the body. ..
- METASTASIS SPECIFIC CARBOHYDRATE ANTIGENSReuben Lotan; Fiscal Year: 1991The amount of sialyl-dimeric LeX antigen (NeuAc2-3Ga11-4(Fuc1- 3)GlcNAc1-3Gal1-4(Fuc1-3)GlcNAc1-) expressed on mucins in human colorectal carcinoma tissues increases upon tumors' progression to the metastatic phenotype...
- MOLECULAR ANALYSIS OF MUCIN TYPE O GLYCOSYLATIONMichael Hollingsworth; Fiscal Year: 2000..The substrates to be used include tandem repeats from different mucins and from mucin-like proteins such as the p-selection ligand PSGL-1...
- REGULATION OF TRACHEA MUCIN SYNTHESIS AND GLYCOSYLATIONJoseph Mendicino; Fiscal Year: 1990..These preliminary studies provide considerable encouragement for success of the studies described in this application...
- Trophoblast Selectins and Their Uterine Mucin LigandsSusan Fisher; Fiscal Year: 2006..MUC7 mediates neutrophil adhesion in the range of shear stresses encountered at oral surfaces, a noel function for mucins. In this context we noted work from other groups that shows uterine expression of MUC1, which also carries sialyl ..
- T. gondii as a model for investigation of Cryptosporidium glycoprotein antigensROBERTA M O apos CONNOR; Fiscal Year: 2010..To address the need for an expression system that mimics post-translational modifications of the native Cp mucins, we expressed Cp glycoproteins in the related apicomplexan Toxoplasma gondii (Tg)...
- DEVELOPMENT OF CELL LINES FROM SUBLINGUAL GLANDSDAVID CULP; Fiscal Year: 1992b>Mucins are the primary secretory component of salivary mucous glands, such as the major sublingual gland and many of the minor salivary glands...