thrombomodulin

Summary

Summary: A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.

Top Publications

  1. ncbi Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain
    Huey Chun Huang
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
    J Biol Chem 278:46750-9. 2003
  2. pmc Thrombomodulin mutations in atypical hemolytic-uremic syndrome
    Mieke Delvaeye
    VIB K U Leuven Vesalius Research Center, Leuven, Belgium
    N Engl J Med 361:345-57. 2009
  3. pmc Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
    Netanel A Horowitz
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 118:2889-95. 2011
  4. ncbi Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation
    C T Ammollo
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Thromb Haemost 9:1795-803. 2011
  5. ncbi Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
    H Saito
    JR Tokai General Hospital, Nagoya, Japan
    J Thromb Haemost 5:31-41. 2007
  6. ncbi Thrombomodulin and its role in inflammation
    Edward M Conway
    Division of Hematology Oncology, Department of Medicine, Centre for Blood Research CBR, University of British Columbia, Vancouver, BC, Canada
    Semin Immunopathol 34:107-25. 2012
  7. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
  8. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
  9. ncbi Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM pro
    Hidemi Ishii
    Department of Public Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Blood 101:4765-74. 2003
  10. pmc Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
    Kazuma Yamakawa
    Department of Emergency and Critical Care, Osaka General Medical Center, 3 1 56 Bandai Higashi, Sumiyoshi ku, Osaka, Japan
    Crit Care 15:R123. 2011

Detail Information

Publications296 found, 100 shown here

  1. ncbi Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain
    Huey Chun Huang
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
    J Biol Chem 278:46750-9. 2003
    b>Thrombomodulin (TM) is an integral membrane glycoprotein that is a potent anticoagulant factor. TM may also possess functions distinct from its anticoagulant activity...
  2. pmc Thrombomodulin mutations in atypical hemolytic-uremic syndrome
    Mieke Delvaeye
    VIB K U Leuven Vesalius Research Center, Leuven, Belgium
    N Engl J Med 361:345-57. 2009
    ..Genetic factors in the remaining cases are unknown. We studied the role of thrombomodulin, an endothelial glycoprotein with anticoagulant, antiinflammatory, and cytoprotective properties, in atypical ..
  3. pmc Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
    Netanel A Horowitz
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 118:2889-95. 2011
    b>Thrombomodulin (TM) is a predominantly endothelial transmembrane glycoprotein that modulates hemostatic function through a domain that controls thrombin-mediated proteolysis and an N-terminal lectin-like domain that controls inflammatory ..
  4. ncbi Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation
    C T Ammollo
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Thromb Haemost 9:1795-803. 2011
    ..The protein C-thrombomodulin (TM) system is a fundamental regulator of coagulation, particularly in the microvasculature, and its activity ..
  5. ncbi Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
    H Saito
    JR Tokai General Hospital, Nagoya, Japan
    J Thromb Haemost 5:31-41. 2007
    Soluble thrombomodulin is a promising therapeutic natural anticoagulant that is comparable to antithrombin, tissue factor pathway inhibitor and activated protein C.
  6. ncbi Thrombomodulin and its role in inflammation
    Edward M Conway
    Division of Hematology Oncology, Department of Medicine, Centre for Blood Research CBR, University of British Columbia, Vancouver, BC, Canada
    Semin Immunopathol 34:107-25. 2012
    The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research...
  7. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..b>Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects...
  8. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy...
  9. ncbi Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM pro
    Hidemi Ishii
    Department of Public Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Blood 101:4765-74. 2003
    The present work investigated the mechanism for down-regulation of thrombomodulin (TM), an anticoagulant glycoprotein, on cultured umbilical vein endothelial cells (HUVECs) exposed to lipid extracts from oxidized low-density lipoprotein (..
  10. pmc Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
    Kazuma Yamakawa
    Department of Emergency and Critical Care, Osaka General Medical Center, 3 1 56 Bandai Higashi, Sumiyoshi ku, Osaka, Japan
    Crit Care 15:R123. 2011
    ..Recombinant human soluble thrombomodulin (rhTM) binds to thrombin to inactivate coagulation, and the thrombin-rhTM complex activates protein C to ..
  11. ncbi Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression
    Ming Te Huang
    Department of Surgery, Taipei Medical University, Taipei City, Taiwan
    Ann Surg Oncol 17:3379-85. 2010
    b>Thrombomodulin (TM) is a key molecule mediating circulation homeostasis through its binding to thrombin. The TM-thrombin complex can activate protein C and thrombin-activatable fibrinolysis inhibitor to form a tight clot...
  12. ncbi A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis
    Sebastiaan Weijer
    Academic Medical Center Amsterdam, Laboratory of Experimental Internal Medicine, Room G2 130, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 106:2761-8. 2005
    b>Thrombomodulin (TM) plays an essential role in the generation of activated protein C (APC), a mediator with both anticoagulant and anti-inflammatory properties, and is preferentially expressed in lungs...
  13. ncbi Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway
    Z Laszik
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Circulation 96:3633-40. 1997
    The protein C anticoagulant pathway is critical to the control of hemostasis. Thrombomodulin and a newly identified receptor for protein C/activated protein C, EPCR, are both present on endothelium...
  14. ncbi Recombinant human soluble thrombomodulin improves mortality and respiratory dysfunction in patients with severe sepsis
    Yoshihito Ogawa
    Department of Emergency and Critical Care, Osaka General Medical Center, Osaka, Japan
    J Trauma Acute Care Surg 72:1150-7. 2012
    ..The purpose of this study was to examine the efficacy of recombinant human soluble thrombomodulin (rhTM), a novel anticoagulant agent, for treating patients with sepsis-induced disseminated intravascular ..
  15. ncbi Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI
    J C Roussel
    Immunology Research Centre, St Vincent s Health, Fitzroy, Victoria, Australia
    Am J Transplant 8:1101-12. 2008
    Incompatibility between pig thrombomodulin (TM) and primate thrombin is thought to be an important factor in the development of microvascular thrombosis in rejecting pig-to-primate xenografts...
  16. ncbi Thrombomodulin links coagulation to inflammation and immunity
    John Morser
    Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, MC5156, Stanford, CA 9435 5156, USA
    Curr Drug Targets 13:421-31. 2012
    b>Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external ..
  17. ncbi Thrombomodulin gene mutations associated with myocardial infarction
    H Ireland
    Department of Haematology, Charing Cross and Westminster Medical School, London, UK
    Circulation 96:15-8. 1997
    b>Thrombomodulin is an important receptor for thrombin on the endothelial cell surface of most blood vessels, including those of the heart...
  18. ncbi Thrombomodulin
    H Weiler
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    J Thromb Haemost 1:1515-24. 2003
    ..analyses of genetically engineered mice have revealed new, and in part PC- and thrombin-independent aspects of thrombomodulin (TM) function in fibrinolysis and inflammation, and in embryogenesis...
  19. pmc Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism
    Linda Nocchi
    Department of Biochemistry, Biology, and Genetics, Polytechnic University of Marche, Ancona, Italy
    J Biol Chem 286:19478-88. 2011
    Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process...
  20. pmc Soluble thrombomodulin protects ischemic kidneys
    Asif A Sharfuddin
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Am Soc Nephrol 20:524-34. 2009
    Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties...
  21. pmc Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice
    Dongmei Song
    Centers for Heart and Lung Research, and Immunology and Inflammation, Feinstein Institute for Medical Research, Long Island Jewish Medical Center, New Hyde Park, NY, USA
    Blood 114:2521-9. 2009
    ..Endothelial NF-kappaB blockade prevented LPS down-regulation of endothelial protein C receptor (EPCR) and thrombomodulin protein expressions, inhibited tissue tumor necrosis factor-alpha converting enzyme activity, reduced EPCR ..
  22. ncbi Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response
    Stephanie T Yerkovich
    Telethon Institute for Child Health Research, Centre for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 123:209-216.e4. 2009
    ..It has been suggested that intrinsic properties of allergens can directly stimulate T(H)2 polarizing functions of DCs, but little is known of the underlying mechanisms...
  23. ncbi An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy
    Gastroenterology 137:2105-11. 2009
    ..We investigated whether plasma from cirrhotic patients has an imbalance of pro- vs anti-coagulation factors...
  24. ncbi Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation
    Marlies Van de Wouwer
    The Center for Transgene Technology and Gene Therapy, University of Leuven and the Flanders Interuniversity Institute for Biotechnology VIB, Belgium
    Arterioscler Thromb Vasc Biol 24:1374-83. 2004
    ..Most of these can be traced to the vasculature, where the systems most intimately interact. Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a ..
  25. pmc Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:502-10. 2011
    b>Thrombomodulin (TM) is a cofactor for thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby helps coordinate coagulation, anticoagulation, fibrinolysis, and inflammation...
  26. ncbi Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells
    Takehiro Takagi
    Department of Immunology, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie Prefecture 514 8507, Japan
    Am J Respir Crit Care Med 183:31-42. 2011
    ..bronchial asthma is caused by inappropriate acquired immune responses to environmental allergens. It is a major health problem, with a prevalence that is rapidly increasing. Curative therapy is not currently available...
  27. pmc Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition
    Yuan Chung Kao
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Mol Cell Biol 30:4767-85. 2010
    The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown...
  28. pmc An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration
    Aruna Ramachandran
    Urological Diseases Research Center, John F Enders Research Laboratories, Room 1077, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Am J Pathol 177:119-31. 2010
    ..Here we show that bladder wall distension leads to PDGFR activation and identify thrombomodulin (TM) as an Akt and AP-1 target in SMC...
  29. pmc Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Critical Care Division, The Institute of Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6068, USA
    Am J Pathol 160:1155-69. 2002
    ..caused by GOX targeting to the endothelial antigens platelet-endothelial cell adhesion molecule (PECAM) and thrombomodulin (TM)...
  30. ncbi Pigs transgenic for human thrombomodulin have elevated production of activated protein C
    Bjorn Petersen
    Institute of Farm Animal Genetics, Department of Biotechnology, Mariensee, Neustadt, Germany
    Xenotransplantation 16:486-95. 2009
    The inability of porcine thrombomodulin (TM) to activate human anticoagulant protein C after pig-to-human xenotransplantation may lead to an aberrant activation of coagulation with microthrombosis and ultimately failure of the ..
  31. ncbi Remodeling of carotid arteries is associated with increased expression of thrombomodulin in a mouse transverse aortic constriction model
    Yi Heng Li
    Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Thromb Haemost 97:658-64. 2007
    b>Thrombomodulin (TM) is an endothelial glycoprotein that functions as a thrombin cofactor in the activation of protein C. Recent evidence has revealed that TM has unique effects on cellular proliferation, adhesion, and inflammation...
  32. ncbi Characterization of a mouse model for thrombomodulin deficiency
    H Weiler
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA
    Arterioscler Thromb Vasc Biol 21:1531-7. 2001
    Mutations in the gene encoding thrombomodulin (TM), a thrombin regulator, are suspected risk factors for venous and arterial thrombotic disease...
  33. ncbi Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system
    Taketoshi Furugohri
    Biological Research Laboratories, R and D Division, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Thromb Haemost 106:1076-83. 2011
    ..inhibitors could enhance TG in human plasma, and whether inhibition of the negative-feedback system [thrombin-thrombomodulin (TM)-protein C] contributed to the TG enhancement...
  34. ncbi Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway
    Christophe Adrie
    Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
    J Am Coll Cardiol 46:21-8. 2005
    ..We investigated coagulation abnormalities in out-of-hospital cardiac arrest (OHCA) patients, with special attention to the protein C anticoagulant pathway...
  35. pmc Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals
    Michael W J Boehme
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    Immunology 107:340-9. 2002
    b>Thrombomodulin is a transmembranous glycoprotein of endothelial cells. In vitro it is a marker of endothelial cell injury. In vivo the levels of serum thrombomodulin are regarded as a parameter of activity in vasculitides...
  36. ncbi Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
    Shock 35:349-54. 2011
    To investigate treatment effects of thrombomodulin alfa (TM-α) in patients with disseminated intravascular coagulation (DIC) having infection as the underlying disease, retrospective subanalysis of a double-blind, randomized controlled ..
  37. ncbi Production of cloned pigs expressing human thrombomodulin in endothelial cells
    Satoko Yazaki
    Prime Tech Ltd, Tsuchiura, Japan
    Xenotransplantation 19:82-91. 2012
    ..Our attention has been directed toward human thrombomodulin (hTM), because it is expected to exhibit the following beneficial effects on coagulation control and ..
  38. ncbi Effects of shear stress on the gene expressions of endothelial nitric oxide synthase, endothelin-1, and thrombomodulin in human retinal microvascular endothelial cells
    Akihiro Ishibazawa
    Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
    Invest Ophthalmol Vis Sci 52:8496-504. 2011
    ..Physiological shear stress is higher in the retinal microcirculatory network than in other organs. The effects of laminar shear stress on gene expression in human retinal microvascular endothelial cells (HRMECs) was investigated...
  39. ncbi Thrombin, thrombomodulin and TAFI in the molecular link between coagulation and fibrinolysis
    M Nesheim
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Thromb Haemost 78:386-91. 1997
    The thrombin thrombomodulin dependent activation of the plasma protein TAFI (Thrombin Activatable Fibrinolysis Inhibitor) and Subsequent Inhibition of Fibrinolysis by the TAFIa is described...
  40. ncbi Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure
    Zhuang Wu
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, 75708, USA
    Blood 119:2422-9. 2012
    ..b>Thrombomodulin (TM), a central player of the anticoagulant protein C system, is regulated by Kruppel-like factor 2 (KLF2) at ..
  41. ncbi Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy
    F Sakamaki
    Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 102:2720-5. 2000
    ..receptor present in endothelial cells and platelets, reflects endothelial injury and platelet activation, and thrombomodulin (TM), a receptor for thrombin and a major anticoagulant proteoglycan on the endothelial membrane, reflects the ..
  42. ncbi The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen
    Cheng Hsiang Kuo
    Department of Biochemistry and Molecular Biology, College of Medicine, National ChengKung University, 1 University Road, Tainan, Taiwan
    Blood 119:1302-13. 2012
    ..Recently, we demonstrated that LeY is a specific ligand of the recombinant lectin-like domain of thrombomodulin (TM)...
  43. ncbi Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation
    Jumei Shi
    Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    Blood Coagul Fibrinolysis 14:575-85. 2003
    Expression of functionally active thrombomodulin (TM) on the luminal surface of endothelial cells is critical for vascular thromboresistance...
  44. ncbi Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori
    Mehrdad Haghazali
    Department of Pathology and Gastroenterology, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University, M C, Tehran, Iran
    Indian J Pathol Microbiol 54:103-6. 2011
    ..Helicobacter pylori infect more than half of the global population. It is suggested to be related with gastritis, peptic ulcer disease (PUD), and gastric cancer...
  45. ncbi Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block
    B Isermann
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    Development 128:827-38. 2001
    The endothelial cell surface receptor thrombomodulin (TM) inhibits blood coagulation by forming a complex with thrombin, which then converts protein C into the natural anticoagulant, activated protein C...
  46. ncbi Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..The protein C anticoagulant system inhibits inflammation resulting from various causes. Thrombomodulin (TM), a widely expressed glycoprotein originally identified in vascular endothelium, is an important cofactor ..
  47. ncbi Evidence of human thrombomodulin domain as a novel angiogenic factor
    Chung Sheng Shi
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Circulation 111:1627-36. 2005
    b>Thrombomodulin is an anticoagulant, endothelial-cell-membrane glycoprotein. A recombinant thrombomodulin domain containing 6 epidermal growth factor-like structures exhibits mitogenic activity...
  48. ncbi Lysophosphatidic acid stimulates thrombomodulin lectin-like domain shedding in human endothelial cells
    Hua Lin Wu
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, ROC
    Biochem Biophys Res Commun 367:162-8. 2008
    b>Thrombomodulin (TM) is an anticoagulant glycoprotein highly expressed on endothelial cell surfaces. Increased levels of soluble TM in circulation have been widely accepted as an indicator of endothelial damage or dysfunction...
  49. ncbi The role of thrombomodulin in atherosclerosis: from bench to bedside
    Yi Heng Li
    Department of Internal, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Cardiovasc Hematol Agents Med Chem 4:183-7. 2006
    ..b>Thrombomodulin (TM) is a cell surface-expressed glycoprotein which is predominantly synthesized by vascular endothelial cells ..
  50. doi Soluble thrombomodulin: a sign of bad times
    Shinichiro Kurosawa
    Crit Care Med 36:985-7. 2008
  51. ncbi Decrease of thrombomodulin contributes to the procoagulant state of endothelium in hemolytic uremic syndrome
    Gabriela C Fernandez
    Division Inmunologia, IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
    Pediatr Nephrol 18:1066-8. 2003
    ..Vascular endothelial cell (EC) injury appears to be central in the pathogenesis of D+HUS. Thrombomodulin (TM) is a glycoprotein present in EC with anti-thrombogenic properties...
  52. pmc Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)
    Lawrence L K Leung
    Department of Medicine, Stanford University School of Medicine and Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Mol Immunol 45:4080-3. 2008
    ..fibrinolysis inhibitor or TAFI) is a plasma procarboxypeptidase that is activated by the thrombin-thrombomodulin complex on the vascular endothelial surface...
  53. ncbi Expression of thrombomodulin on monocytes is associated with early outcomes in patients with coronary artery bypass graft surgery
    Chien Sung Tsai
    Division of Cardiovascular Surgery, Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, No 325 Sec 2 Cheng Kung Road, Neihu, Taipei, Taiwan
    Shock 34:31-9. 2010
    b>Thrombomodulin (TM) mediates blood coagulation and inflammation and is expressed constitutively on resting monocytes. This expression might be a key regulator of monocyte-related inflammation...
  54. ncbi Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome
    M S Bajaj
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri, USA
    Intensive Care Med 25:1259-66. 1999
    ..plasma levels of three endothelial-specific proteins, von Willebrand factor (vWF), tissue factor pathway inhibitor (TFPI) and thrombomodulin (TM) may be useful in predicting the development of acute respiratory distress syndrome (ARDS).
  55. ncbi Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokeratin, and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomas
    Douglas C Parker
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Surg Pathol 27:1-10. 2003
    ..We evaluated a panel consisting of antibodies to uroplakin III (UROIII), thrombomodulin (THR), high molecular weight cytokeratin (HMWCK), and cytokeratin 20 (CK20) in a wide range of urothelial ..
  56. ncbi Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia
    Masaru Nagato
    Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Crit Care Med 37:2181-6. 2009
    ..Therefore, the therapeutic efficacy of recombinant human soluble thrombomodulin (ART-123) administration on the production of inflammatory cytokines and the plasma level of HMGB1 was ..
  57. ncbi Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer
    Po Len Liu
    Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Mol Carcinog 49:874-81. 2010
    b>Thrombomodulin (TM) plays a role in coagulation, inflammation, and cell adhesion...
  58. pmc A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 101:1983-91. 1998
    ..coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent generation of activated protein C and suppression of thrombin production...
  59. pmc Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis
    Junru Wang
    Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Am J Pathol 160:2063-72. 2002
    ..We examined radiation-induced changes in endothelial thrombomodulin (TM) and protease-activated receptor-1 (PAR-1) in irradiated intestine, and their relationship to structural, ..
  60. ncbi Elevated circulating soluble thrombomodulin activity, tissue factor activity and circulating procoagulant phospholipids: new and useful markers for pre-eclampsia?
    Aurélie Rousseau
    DIAGNOSTICA STAGO, PAE Parispace 3, 125 Avenue Louis Roche, 92635 Gennevilliers Cedex, France
    Eur J Obstet Gynecol Reprod Biol 146:46-9. 2009
    ..The aims of this study were to investigate the activities of thrombomodulin, tissue factor and procoagulant phospholipids to assess endothelial cell injury in pregnant women with pre-..
  61. ncbi Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation
    Hsi Ju Wei
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Cardiovasc Res 92:317-27. 2011
    ..b>Thrombomodulin (TM) inhibits thrombin effects by binding thrombin through its domains 2 and 3 (TMD23)...
  62. ncbi Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation
    T Ito
    Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Thromb Haemost 9:168-73. 2011
    b>Thrombomodulin (TM) is an endothelial anticoagulant cofactor that promotes thrombin-mediated activation of protein C...
  63. pmc The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
    Edward M Conway
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    J Exp Med 196:565-77. 2002
    b>Thrombomodulin (TM) is a vascular endothelial cell (EC) receptor that is a cofactor for thrombin-mediated activation of the anticoagulant protein C...
  64. ncbi Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation
    Yuko Miwa
    Department of Applied Immunology, Nagoya University School of Medicine, Nagoya, Japan
    Xenotransplantation 17:26-37. 2010
    ..Molecular incompatibilities in the coagulation systems between pigs and humans, such as the thrombomodulin (TM)-protein C system or direct prothrombinase activity, have been suggested as possible causes...
  65. ncbi Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
    Bicheng Nan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Mail stop NAB 2010, Houston, TX 77030, United States
    Thromb Res 115:417-26. 2005
    ..of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a ..
  66. pmc The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
    Kazuhiro Abeyama
    Department of Laboratory and Molecular Medicine, Shin Nippon Biomedical Laboratories Inc SNBL, Kagoshima University, Japan
    J Clin Invest 115:1267-74. 2005
    b>Thrombomodulin (TM) is an endothelial anticoagulant cofactor that promotes thrombin-mediated formation of activated protein C (APC). We have found that the N-terminal lectin-like domain (D1) of TM has unique antiinflammatory properties...
  67. ncbi Calibrated automated thrombin generation measurement in clotting plasma
    H Coenraad Hemker
    Synapse BV, Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands
    Pathophysiol Haemost Thromb 33:4-15. 2003
    ..g. aspirin and abciximab). Addition of activated protein C (APC) or thrombomodulin inhibits thrombin generation and reflects disorders of the APC system (congenital and acquired resistance, ..
  68. ncbi Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin
    K Peter
    Department of Cardiology, University of Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 17:505-12. 1997
    ..8, P < .001). In contrast, circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin (as markers for endothelial cell damage) did not correlate with the extent of atherosclerosis...
  69. pmc Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Hongo Bunkyo ku, Tokyo, 113 8421, Japan
    Crit Care 13:R203. 2009
    Recombinant human soluble thrombomodulin (rhsTM) is newly developed for the treatment of DIC. The purpose of this study was to evaluate the efficacy of the concomitant administration of rhsTM and antithrombin (AT).
  70. ncbi Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress
    Joanna Rossi
    Dept of Chemical Engineering, McGill University, 3610 University Street, Montreal, QC, Canada
    Life Sci 87:92-9. 2010
    ..In this study, we investigated the combined effect of laminar shear stress (LSS) and statins on endothelial cell gene expression...
  71. ncbi Regulation of inflammation by the protein C system
    Hartmut Weiler
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA
    Crit Care Med 38:S18-25. 2010
    ..To review new findings about the function of the protein C system during inflammation and coagulation...
  72. ncbi Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro
    Lien Cheng Chen
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, ROC
    J Infect 58:368-74. 2009
    ..However, the mechanism to cause hemorrhage in DV infections remains poorly understood. Thrombomodulin (TM), expressed on the surface of endothelial cells and monocytes, is very important in regulation of ..
  73. ncbi Effects of human soluble thrombomodulin on experimental glomerulonephritis
    Hiroshi Ikeguchi
    Internal Medicine III, Nagoya University School of Medicine, Nagoya, Japan
    Kidney Int 61:490-501. 2002
    ..The present study was performed to evaluate the effects of recombinant human soluble thrombomodulin (RHS-TM) in a lethal model of thrombotic glomerulonephritis and to investigate the possible mechanisms.
  74. pmc Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response
    Chung Sheng Shi
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Taiwan
    Blood 112:3661-70. 2008
    b>Thrombomodulin (TM), a widely expressing glycoprotein originally identified in vascular endothelium, is an important cofactor in the protein C anticoagulant system...
  75. ncbi Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma
    M G Elisen
    Department of Haematology, University Hospital and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Blood 91:1542-7. 1998
    ..Recently it was found, using purified proteins, that the anticoagulant thrombin-thrombomodulin complex was also inhibited by PCI...
  76. ncbi Thrombomodulin structure and function
    J E Sadler
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Thromb Haemost 78:392-5. 1997
    b>Thrombomodulin is protein cofactor expressed on endothelial cell surfaces that modifies the substrate specificity of thrombin, apparently by an allosteric mechanism...
  77. ncbi Comparison of soluble thrombomodulin, von Willebrand factor, tPA/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte) stored at -70 degrees C for 8-11 years
    Torbjörn K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Thromb Res 116:249-54. 2005
    The aim was to define the most suitable specimen collection tubes for measurements of soluble Thrombomodulin (sTM), von Willebrand factor (vWF), and tPA/PAI-1 complex concentrations, and in particular whether the strongly acidic citrate ..
  78. ncbi Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line
    Hyun Kyung Kim
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Blood Coagul Fibrinolysis 18:157-64. 2007
    b>Thrombomodulin has a central role in the regulation of coagulation through its abilities to promote generation of the potent anticoagulant activated protein C...
  79. ncbi Association study of the thrombomodulin -33G>A polymorphism with coronary artery disease and myocardial infarction in Chinese Han population
    Jiangong Zhao
    Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road 167, Beijing 100037, China
    Int J Cardiol 100:383-8. 2005
    b>Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C...
  80. ncbi A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:2069-79. 2013
    To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation.
  81. ncbi C-terminal site-specific PEGylation of a truncated thrombomodulin mutant with retention of full bioactivity
    Chrystelle S Cazalis
    Laboratory for Biomolecular Materials Research, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Bioconjug Chem 15:1005-9. 2004
    ..We report herein a strategy for site-specific PEGylation of a thrombomodulin (TM) derivative at the C terminus...
  82. ncbi Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population
    Shoko Sugiyama
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Thromb Res 119:35-43. 2007
    b>Thrombomodulin (TM) is an essential cofactor in protein C activation by thrombin. Here, we evaluated the contribution of genetic variations in the TM gene to soluble TM (sTM) level and deep vein thrombosis (DVT) in Japanese.
  83. ncbi Protein C and thrombomodulin in human acute lung injury
    Lorraine B Ware
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 285:L514-21. 2003
    Decreased circulating protein C and increased circulating thrombomodulin are markers of the prothrombotic, antifibrinolytic state associated with poor outcomes in sepsis but have not been measured in patients with ALI (acute lung injury)/..
  84. ncbi Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro
    Ling Yuh Shyu
    Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
    Thromb Res 129:43-9. 2012
    ..In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1)...
  85. ncbi Heme oxygenase-1 modulates thrombomodulin and activated protein C levels to attenuate lung injury in cecal ligation and puncture-induced acute lung injury mice
    Dongsheng Fei
    Department of ICU, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Exp Lung Res 38:173-82. 2012
    ..Enzyme-linked immunosorbent assay (ELISA) was performed to measure plasma thrombomodulin (TM) and activated protein C (APC) levels...
  86. pmc Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells
    T Oikawa
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 69:1059-64. 1994
    ..Further, we also investigated whether these cells produce thrombomodulin (TM), another product of endothelial cells functioning as a modulator of procoagulant activity...
  87. ncbi Dysfunction of endothelial protein C activation in severe meningococcal sepsis
    S N Faust
    Department of Paediatrics, Imperial College School of Medicine at St Mary's Hospital, London, United Kingdom
    N Engl J Med 345:408-16. 2001
    ..We studied the expression of thrombomodulin and the endothelial protein C receptor in the dermal microvasculature of children with severe meningococcemia ..
  88. ncbi Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia
    B Hira
    MRC UN Pregnancy Hypertension Research Unit, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    BJOG 110:327-8. 2003
    ..to detect the G or A allele at residue 506 of the Factor V gene, and the C or T allele at residue 455 of the thrombomodulin gene...
  89. ncbi Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells
    Helga Schinkel
    Fraunhofer Institut für Molekularbiologie und Angewandte Oekologie, IME, Worringerweg 1, 52074 Aachen, Germany
    Transgenic Res 14:251-9. 2005
    b>Thrombomodulin is a membrane-bound protein that plays an active role in the blood coagulation system by binding thrombin and initiating the protein C anticoagulant pathway...
  90. ncbi Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Circ Res 78:180-7. 1996
    ..the reporter gene bacterial beta-galactosidase was inserted via homologous recombination into the intronless thrombomodulin locus of murine embryonic stem cells...
  91. ncbi A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
    L Norlund
    Department of Laboratory Medicine, University of Lund, University Hospital, Sweden
    Thromb Haemost 77:248-51. 1997
    ..b>Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C ..
  92. ncbi Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide
    Anita W Rijneveld
    Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 103:1702-9. 2004
    The thrombomodulin-protein C-protein S (TM-PC-PS) pathway exerts anticoagulant and anti-inflammatory effects...
  93. ncbi Soluble thrombomodulin and brain infarction: case-control and prospective study
    Jean Marc Olivot
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, Paris, France
    Stroke 35:1946-51. 2004
    Increased soluble thrombomodulin (sTM) concentration has been associated with recurrent coronary events, whereas in one prospective study it predicted fewer first-ever coronary events...
  94. ncbi TNF-α-decreased thrombomodulin expression in monocytes is inhibited by propofol through regulation of tristetraprolin and human antigen R activities
    Feng Yen Lin
    Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan
    Shock 36:279-88. 2011
    b>Thrombomodulin (TM) is expressed on the surface of monocytes and is a key regulator of actual immune capacity. Propofol is an anesthetic agent that exerts anti-inflammatory effects...
  95. ncbi Changes in serum interleukin-6, C-reactive protein and thrombomodulin levels under periodontal ultrasonic debridement
    Yuka Ushida
    Department of Hard Tissue Engineering, Section of Periodontology, Graduate School, Tokyo, Japan
    J Clin Periodontol 35:969-75. 2008
    This study aimed to compare the effect of single-visit full-mouth mechanical debridement (FMD) and quadrant-wise mechanical debridement (QMD) on the levels of serum interleukin (IL)-6, C-reactive protein (CRP) and soluble thrombomodulin.
  96. ncbi Calcium-binding sites of the thrombin-thrombomodulin-protein C complex: possible implications for the effect of platelet factor 4 on the activation of vitamin K-dependent coagulation factors
    Likui Yang
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Thromb Haemost 97:899-906. 2007
    The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0...
  97. ncbi Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke
    Jean Marc Olivot
    INSERM U698 and Denis Diderot University Paris VII, Dept of Neurology and Stroke Center, Bichat University Hospital, Paris, France
    J Neurol 255:514-9. 2008
    b>Thrombomodulin is expressed at the surface of endothelial cells and controls thrombin generation and thrombin-induced platelets and vascular cell activation...
  98. pmc Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors
    Toyoko Hiroi
    Department of Medicine, Johns Hopkins School of Medicine, Ross 1165, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Arterioscler Thromb Vasc Biol 29:1587-93. 2009
    Impairment of the thrombomodulin-protein C anticoagulant pathway has been implicated in pathological thrombosis associated with malignancy...
  99. ncbi Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin
    Y D Dean
    Brain Inflammation and Immunity Group, Medical Biochemistry Department, University of Wales College of Medicine, Cardiff, CF144XN, United Kingdom
    J Biol Chem 275:34382-92. 2000
    ..of C-type lectin-like family and, interestingly, displays similar domain composition and organization to thrombomodulin. Northern blot and reverse transcriptase-polymerase chain reaction analyses indicated that rat AA4 was encoded ..
  100. ncbi Separation and characterization of the molecular species of thrombomodulin in the plasma of diabetic patients
    S Uehara
    Department of Internal Medicine, Ohtaki Onsen Hospital, Ohtaki, Usugun, Hokkaido, Japan
    Thromb Res 104:325-32. 2001
    b>Thrombomodulin (TM) and its molecular species have been identified as markers of vascular endothelial cells (EC)...
  101. ncbi Plasma levels of adiponectin and soluble thrombomodulin in hypothyroid patients with normal thyroid function following levothyroxine replacement therapy
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Internal Medicine, 1 4 3, Asahi machi, Osaka 545 8585, Japan
    Biomed Pharmacother 59:571-7. 2005
    ..carotid artery (CCA), an indicator of early atherosclerosis, and cardiovascular parameters including soluble thrombomodulin (sTM), a plasma endothelial injury marker...

Research Grants62

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..As part of a normal control mechanism, thrombin binds to a protein on the blood vessel surface called thrombomodulin and in that context, thrombin's function is "modulated'and will activate two other proteins, protein ..
  2. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..isolated from swine peripheral blood, by over-expressing the anticoagulant and anti-inflammatory protein thrombomodulin (TM) before the cells are seeded on the inside of titanium (Ti) tubes...
  3. Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis
    Steven M Kawut; Fiscal Year: 2010
    ..gender, race, and ethnicity, 2) to determine whether plasma measures, such as von Willebrand factor, soluble thrombomodulin, C-reactive protein, interleukin-6, and fibrinogen, are associated with RV mass and RV ejection fraction, and ..
  4. The Regulation of Inflammatory Responses by CD73
    Linda F Thompson; Fiscal Year: 2012
    ..Exciting new data suggest that CD73-generated adenosine also regulates the expression of thrombomodulin, an important anticoagulant and anti-inflammatory protein...
  5. Recombinant and Chemo-/Bio-Orthogonal Synthesis of Liposomal Thrombomodulin
    Xue Long Sun; Fiscal Year: 2013
    ..Endothelial thrombomodulin (TM) plays a critical role in local haemostasis by binding thrombin and subsequently converting protein C to ..
  6. KLF2 as a regulator of endothelial cell biology
    MUKESH KUMAR JAIN; Fiscal Year: 2012
    ..this factor directly regulates the expression of potent anti-inflammatory and anti-thrombotic factors such as thrombomodulin (TM) and endothelial nitric oxide synthase (eNOS)...
  7. Thrombomodulin Receptors on Immune Cells
    John Morser; Fiscal Year: 2013
    ..Our long-term goal is to understand how the coagulation cascade modulates the immune response. Thrombomodulin (TM) is a cell surface glycoprotein that binds thrombin, the key effector enzyme of the coagulation cascade, ..
  8. PPG - Mechanisms of Cardiovascular Protection and Disease
    Donald D Heistad; Fiscal Year: 2013
    ..oxidation reaction, protein methionine oxidation, impairs anti-coagulant function of the endothelial protein thrombomodulin, and thereby contributes to the prothrombotic phenotype of atherosclerosis...
  9. Hemodynamic Regulation of Thromboresistance
    Jeffrey J Rade; Fiscal Year: 2010
    ..b>Thrombomodulin (TM), a key component of the protein C anticoagulant pathway, is critical to maintaining vascular ..
  10. EPCR, TAFI as Regulators of PMN/Endothelial Interaction
    Florea Lupu; Fiscal Year: 2009
    ..EPCR and thrombomodulin (TM) are at the point of attack and therefore are both targets and regulators of this interaction through ..
  11. Complement inhibition as sepsis therapy
    Florea Lupu; Fiscal Year: 2013
    ..will determine if, and through what mechanisms, complement inhibition by the recombinant lectin-like domain of thrombomodulin (TM-LLD) could prevent organ failure and improve outcome in our sepsis model...
  12. KLF4 , the endothelium, and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..2) KLF4 induces the expression of flow-regulated factors such as endothelial nitric oxide synthase (eNOS) and thrombomodulin (TM)...
  13. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
    During the previous funding period, we have gathered strong evidence that binding of thrombomodulin (TM) at exosite 1 on thrombin alters the active site of the enzyme towards protein C activation...
  14. Thromboregulatory strategies to prolong xenograft survival.
    Simon Robson; Fiscal Year: 2009
    ..An example of this would be the failure of natural porcine anticoagulants, such as thrombomodulin, to interact with human/primate coagulation factors, such as thrombin and Protein C...
  15. Targeted delivery of thrombomodulin in lung disease
    Vladimir R Muzykantov; Fiscal Year: 2013
    ..The endothelial cell (EC) transmembrane glycoprotein, thrombomodulin (TM), controls these processes directly and via binding and "redirecting" the activities of thrombin, from ..
  16. Studies on anticoagulant properties of thrombin
    Enrico Di Cera; Fiscal Year: 2013
    ..We will test the hypothesis that R169 of protein C is not exposed to solvent and that the action of thrombomodulin is to induce exposure of R169 to enable thrombin cleavage...
  17. Genetically-engineered pig organ transplantation into nonhuman primates
    DAVID KC COOPER; Fiscal Year: 2013
    ..heart Tx (n=6) or (B) life-supporting kidney Tx (n=6) from GE/CIITA pigs additionally transgenic for human thrombomodulin (TBM) in baboons immunosuppressed with a clinically-applicable regimen, and to determine the causes of graft ..
  18. Site-specific therapies to prevent intimal hyperplasia
    Elliot Chaikof; Fiscal Year: 2013
    ..plan to define the capacity of recombinant anti-thrombotic fusion proteins based upon scFvanti-LIBS and either thrombomodulin (TM) or the direct Xa inhibitor, tick anticoagulant peptide (TAP), to selectively target activated platelets ..
  19. Endothelial Progenitor Cell Seeded Self-Expanding Vascular Stent
    HARDEAN ERIC ACHNECK; Fiscal Year: 2012
    ..oxide production by quantifying nitrite in media samples with an Ionics/Sievers Nitric Oxide Analyzer and thrombomodulin expression by EPCs on the stent surface with Western blot analysis under different flow conditions...
  20. Proteinase Allostery and the Regulation of Blood Coagulation
    Sriram Krishnaswamy; Fiscal Year: 2013
    ..We will now employ titration calorimetry to establish the thermodynamic basis by which thrombomodulin (TM), which binds to ABE1, selectively stabilizes and favors proteinase-like forms to oppose the effects of ..
  21. Molecularly Engineered Blockade of Islet Induced Inflammatory Responses
    Elliot Chaikof; Fiscal Year: 2013
    ..ultrathin film that presents peptide ligands to ss cells and ECs at the inner film interface, while localizing thrombomodulin (TM) at the outer surface...
  22. EPC Adhesion to Teflon-AF and ePTFE Vascular Grafts
    WILLIAM MONTGOMERY REICHERT; Fiscal Year: 2012
    ..the peripheral blood of adults with coronary artery disease, (2) transfect the EPCs with the gene for human thrombomodulin (hTM), (3) verify the adherence and expression of antithrombotic markers in native and hTM transfected EPCs ..
  23. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2009
    ..Antibodies that block the function of protein C pathway members (e.g., protein C, thrombomodulin, endothelial protein C receptor) will be infused with sub-lethal challenge to evaluate individual ..
  24. Structure-function of cytoprotective coagulation proteases and their receptors
    LAURENT OLIVIER MOSNIER; Fiscal Year: 2013
    ..associated with "off-target" Heparin-Induced Thrombocytopenia (HIT) antibodies against PF4-EPCR and PF4-thrombomodulin (TM) complexes...
  25. Inflammatory Mechanisms in Arteriogenesis
    Armin Helisch; Fiscal Year: 2012
    ..Specific Aim II is to define the role of the primarily anti-inflammatory cell surface anticoagulant thrombomodulin in arteriogenesis in the same model...
  26. Physiological Role of Fibrin Anti-Thrombin I Activities
    MICHAEL MOSESSON; Fiscal Year: 2005
    ..on thrombosis, factor XIII-mediated crosslinking, and fibrinolysis, and carry out an interaction screen in thrombomodulin-deficient mice (TM pro, TM flox) to assess whether the hu-y' phenotype ameliorates or exacerbates the ..
  27. MOLECULAR MECHANISM OF THROMBIN INHIBITION
    Scott Cooper; Fiscal Year: 2003
    ..which the serpins antithrombin (AT) and protein C inhibitor (PCI) inhibit free thrombin and thrombin bound to thrombomodulin (TM)...
  28. NEW BIOMEDICAL INTERFACE MATERIALS
    Roger Marchant; Fiscal Year: 2002
    ..functions will be achieved through pendant heparin oligosaccharides and bioactive oligopeptides derived from thrombomodulin. The effect of biomimetic modifications on interfacial properties and blood compatibility will be determined ..
  29. THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMEN
    Paul Ridker; Fiscal Year: 2002
    ..They will also explore common genetic polymorphisms in the tPA, PAI-1, MTHFR, thrombomodulin, prothrombin, and factor V genes so that both inherited and environmental determinants of coronary thrombosis ..
  30. STRUCTURAL ANALYSIS OF THROMBIN SPECIFICITY SITS
    HENRY JAKUBOWSKI; Fiscal Year: 1991
    ..The chief control step occurs when thrombin binds to thrombomodulin (TM), a transmembrane, endothelial cell protein of the blood vessel wall...
  31. POSTDOCTORAL HEMATOLOGY RESEARCH TRAINING
    George Dale; Fiscal Year: 2003
    ..This program is divided into three tracks. 1. Hemostatic proteins (structure and function) including thrombomodulin, endothelial protein C receptor, proteins C and S, factors V and VIII/vWF, tissue factor/factor VII and ..
  32. Stroke:Role of aPL, hemostatic markers, and telestroke
    Steven Levine; Fiscal Year: 2006
    ..3) The role of aPL-P, thrombin-antithrombin complexes, tissue plasminogen activator antigen levels, and thrombomodulin in predicting treatment response, outcome, and intracerebral hemorrhage risk in the NINDS rt-PA Stroke Trial ..
  33. VLDL, ATHEROSCLEROSIS, AND THROMBOSIS-MECHANISTIC LINKS
    William Bradley; Fiscal Year: 1993
    ..Thrombogenic by promoting endothelial cell (EC) procoagulant activity (increase tissue factor (TF), decrease thrombomodulin (TM) activity) and by inhibiting the net activators (PA); stimulate synthesis and (inhibit release and ..
  34. ANTIPHOSPHOLIPID SYNDROME AND THE PROTEIN C PATHWAY
    Robert Roubey; Fiscal Year: 2000
    ..characterization, and purification of autoantibodies directed against protein C protein S, thrombin, thrombomodulin, factor V, and beta2GPI, and correlation of these autoantibodies with clinical manifestations of the a aPL ..
  35. Direct Cellular Effects of Blood Coagulation Proteases
    LAURENT OLIVIER MOSNIER; Fiscal Year: 2010
    ..I propose: 1) To characterize the formation of endothelial cell membrane receptor complexes between thrombomodulin, endothelial protein C receptor and protease activated receptor-1 required for APC generation and APC's ..
  36. PROTEIN SORTING TO ENDOTHELIAL CELL SECRETORY GRANULES
    Yvonne Datta; Fiscal Year: 2001
    ..Lastly will be determined whether the P-selectin cytoplasmic domain fused to thrombomodulin, an anti-thrombotic protein, can be targeted to the WPB for rapid expression in response to agonists...
  37. REGULATORY ROLES OF LACTOFERRIN IN HEMOSTASIS
    Haifeng Wu; Fiscal Year: 2003
    ..the generation of activated protein C and the specific binding of lactoferrin to chondroitin sulfate moiety of thrombomodulin will be examined...
  38. Capillary DNA Sequencer/Genetic Analyzer
    LESTER CASHDOLLAR; Fiscal Year: 2003
    ..to Study the In Vivo Consequences of Constitutive Integrin Activation and Functions of the PECAM-1 ITIM; Thrombomodulin Function in Cellular Physiology; Mouse Model of Juvenile Onset Thrombosis; Use of Genomic Technologies to ..
  39. BIOPHYSICAL STUDIES OF THROMBOMODULIN EGF DOMAINS
    ELIZABETH KOMIVES; Fiscal Year: 1999
    DESCRIPTION: Thrombomodulin (TM) is an essential anticoagulant protein that binds to thrombin and the resulting complex shuts down further production of thrombin...
  40. VASCULAR ENDOTHELIUM FORM AND FUNCTION: EFFECTS OF GLIA
    LAWRENCE DEBAULT; Fiscal Year: 1990
    ..regenerating vessel, restoration of barrier function to tracers, the fate of endothelial cell Factor VIII and Thrombomodulin (TM) antigens during regeneration, and induction (or activation) or gamma-glutamyl transpeptidase (GGTP) ion ..
  41. Genetics of Early Onset-Stroke
    Steven Kittner; Fiscal Year: 2007
    ..Current evidence suggests that the genes encoding the thrombomodulin - protein C and fibrinolysis systems are promising candidate stroke susceptibility genes because of their ..
  42. NATURAL ANTICOAGULANT MECHANISMS
    Robert Rosenberg; Fiscal Year: 1999
    ..of this proposal is to establish genetically-based animal models for investigating the in vivo role of thrombomodulin (TM) in suppressing thrombosis...
  43. Computation and Mass Spec: Predicting Protein Complexes
    Lynn Ten Eyck; Fiscal Year: 2007
    ..of our coordinated computational/mass-spectrometry docking method on protein kinase complexes and on thrombin-thrombomodulin complexes; (3) Extend the combined computational/experimental approach to systems that change conformation on ..
  44. ACTIVATION OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 1992
    ..the tissue factor (TF)/VIIa complex in terms of physical and kinetic interactions; to evaluate factor Xa/thrombomodulin interactions; to study surface dependent coagulation reactions using total internal reflectance fluorescence (..
  45. Smoking, thrombomodulin oxidation, and thrombosis
    WESLEY STITES; Fiscal Year: 2009
    Smokers are well known to be at elevated risk of cardiovascular disease and thrombosis. Thrombomodulin is a key regulator of blood clotting...
  46. ANTIINFLAMMATORY EFFECTS OF PROTEIN C & THROMBOMODULIN
    Wayne Hancock; Fiscal Year: 2000
    ..e.g. Activated protein C (aPC), protein S (PS) and thrombomodulin (TM), in addition to their known anticoagulant actions, constitute a physiologic pathway which modulates ..
  47. KLF2, PPARalpha and Atherothrombosis
    Zhiyong Lin; Fiscal Year: 2009
    ..this proposal, Specific Aim 1 is designed to delineate the molecular basis for KLF2's ability to regulate thrombomodulin under basal and laminar flow conditions...
  48. Role of the Protein C System in Blood Vessel Repair
    Lea Beaulieu; Fiscal Year: 2006
    ..protein C (PC) binds to endothelial cell protein C receptor and is activated by thrombin (lla) bound to thrombomodulin. Activated protein C (APC) inactivates factors Va and Villa with protein S (PS), reducing further lla ..
  49. ENDOTHELIAL CELL OUTGROWTH FROM BLOOD
    Robert Hebbel; Fiscal Year: 2001
    ..the feasibility of using these cells for diagnosis for endothelial-based disorders, we will assay them for thrombomodulin activity in normals, in persons known to have non-functional mutant thrombomodulin, and in patients with ..
  50. ANTICOAGULANT PROTEIN COMPLEX STRUCTURE AND FUNCTION
    Timothy Mather; Fiscal Year: 2003
    ..The pathway is initiated when thrombin (T) binds to thrombomodulin (TM) on the endothelium and undergoes a cofactor dependent allosteric conformational change...
  51. Arteries Engineered from Porcine Vascular Cells
    Laura Niklason; Fiscal Year: 2005
    ..Cultured endothelial cells decrease expression of thrombomodulin, which is an important anti-coagulant in the native arterial system...
  52. Mechanisms of vaso-occlusion in sickle cell disease
    CHERYL HILLERY; Fiscal Year: 2005
    ..evolution of sickle cell-induced vascular pathology, and 3) Study the effect of modulation of the protein C/thrombomodulin pathway on the evolution of HbS-induced organ pathology...
  53. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    Alireza R Rezaie; Fiscal Year: 2010
    ....
  54. Arachidonic Acid Metabolism in Blood and Vascular Cells
    Jun Yang Liou; Fiscal Year: 2006
    ..Information provided by studies from this renewal application will have great impact on understanding the fundamental cytoprotection process and offer an excellent opportunity for developing new therapeutic agents. ..
  55. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  56. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  57. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  58. Structural Mechanisms for the Inhibition of Thrombosis
    JAMES HUNTINGTON; Fiscal Year: 2009
    ....
  59. MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHY
    Martin Hauer Jensen; Fiscal Year: 2005
    ..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..