Genomes and Genes
par 1 receptor
Summary: A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased PHOSPHOLIPASE C and increased PHOSPHOLIPASE A2.
Publications198 found, 100 shown here
- Proteinase-activated receptorsS R Macfarlane
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
Pharmacol Rev 53:245-82. 2001..The future identification of other PARs and their modes of activation are an important future direction for this expanding field of study...
- PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cellsAdrienne Boire
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Cell 120:303-13. 2005..These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion...
- Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerizationJoseph N McLaughlin
Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 104:5662-7. 2007..Because PAR3 is a critical determinant of PAR1 function, targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation...
- Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesisJessica S Blackburn
Department of Biochemistry, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Pathol 173:1736-46. 2008....
- Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthmaD A Knight
Asthma and Allergy Research Institute Inc, Nedlands, Western Australia, Australia
J Allergy Clin Immunol 108:797-803. 2001..PARs are activated by endogenous proteases, including thrombin (PAR-1, -3, and -4) and tryptase (PAR-2 and -4), both of which are present in inflamed airways...
- Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosisDavid C J Howell
Centre for Respiratory Research, University College London, The Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
Am J Pathol 166:1353-65. 2005....
- Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1P J O'Brien
Departments of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 275:13502-9. 2000..Such transactivation may limit the effectiveness of PAR1 antagonists, which compete with the tethered ligand domain rather than preventing PAR1 cleavage...
- An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexinsAnuradha Gullapalli
Department of Pharmacology, University of North Carolina at Chapel Hill, NC 27599 7365, USA
Mol Biol Cell 17:1228-38. 2006..Together, our findings establish an essential role for endogenous SNX1 in sorting activated PAR1 to a distinct lysosomal degradative pathway that is independent of retromer, Hrs, and Tsg101...
- 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damageNicole C Kaneider
Departments of Medicine and Biochemistry, Molecular Oncology Research Institute, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nat Immunol 8:1303-12. 2007..Unexpectedly, we found that the protective effects of PAR1 required transactivation of PAR2 signaling pathways. Our results suggest therapeutics that selectively activate PAR1-PAR2 complexes may be beneficial in the treatment of sepsis...
- Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritisM A Cunningham
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 3168 Victoria, Australia
J Exp Med 191:455-62. 2000..These results indicate that activation of PAR-1 by thrombin or TRAP amplifies crescentic GN. Thus, in addition to its procoagulant role, thrombin has proinflammatory, PAR-1-dependent effects that augment inflammatory renal injury...
- Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasionMichelle A Booden
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
Mol Cell Biol 24:1990-9. 2004..Thus, our results reveal that a novel alteration in trafficking of activated PAR1 causes persistent signaling and, in addition to other processes and proteins, contributes to breast carcinoma cell invasion...
- Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cellsBarbara Uzonyi
Institute for Vascular Medicine aud Institute for Medical Statistics, Computer Sciences, and Documentation, Friedrich Schiller University, Bachstrasse 18, 07743 Jena, Germany
Proc Natl Acad Sci U S A 103:6326-31. 2006..These data show that cysLT2-R activation results in a proinflammatory EC phenotype. Because LTD4 and thrombin are likely to be formed concomitantly in vivo, cysLT2-R and PAR-1 may cooperate to augment vascular injury...
- Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cellsEric Camerer
Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
J Biol Chem 277:16081-7. 2002..This information is critical for the design and interpretation of knockout mouse studies to probe the possible roles of Xa signaling in vivo...
- Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cellsArshad Rahman
Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612 7343, USA
Circ Res 91:398-405. 2002..These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt...
- Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapyA Kuliopulos
Molecular Cardiology Research Institute, Division of Hematology Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
Biochemistry 38:4572-85. 1999..Truncation of the wild-type receptor at the C-terminal plasmin-cleavage sites removes the N-terminal tethered ligand or preligand, thereby providing an effective pathway for PAR1 desensitization in vivo...
- Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteriesJ R Hamilton
Department of Pharmacology, University of Melbourne, Victoria, Australia
J Cardiovasc Pharmacol 38:108-19. 2001..We conclude that human pulmonary arteries express PAR1, PAR2, and PAR4, but that only PAR1, or a PAR1-like receptor, is coupled to endothelium-dependent relaxation...
- Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cellsKristina K Hansen
Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
Immunology 112:183-90. 2004....
- Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylationChii Heui Chen
Department of Pharmacology, Cardiovascular Biology Center, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill 27599 7365, USA
J Biol Chem 279:10020-31. 2004..These findings reveal a new level of complexity in the regulation of protease-activated GPCR signaling...
- Review article: proteinase-activated receptors - novel signals for gastrointestinal pathophysiologyN Vergnolle
Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada
Aliment Pharmacol Ther 14:257-66. 2000..Nonetheless, the use of PAR agonists has already highlighted new potential functions for proteinases in the gastrointestinal tract, thus the control of PAR activation might represent a promising therapeutic target...
- Human corneal epithelial cells express functional PAR-1 and PAR-2Roland Lang
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
Invest Ophthalmol Vis Sci 44:99-105. 2003..The objective of this study was to examine whether HCECs express functional proteinase-activated receptor (PAR)-1 and -2 and evaluate the effects of receptor activation on corneal epithelial cell proinflammatory cytokine production...
- Regulated shedding of PAR1 N-terminal exodomain from endothelial cellsMatthew J Ludeman
Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
J Biol Chem 279:18592-9. 2004..Nonetheless, regulated shedding of G protein-coupled receptors represents a new mechanism by which signaling by this important class of receptors might be modulated...
- Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivationClemens Feistritzer
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Blood 105:3178-84. 2005....
- Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblastsN M Schechter
Department of Dermatology, University of Pennsylvania, Philadelphia 19104 6142, USA
J Cell Physiol 176:365-73. 1998..These results suggest that the proteases tryptase and chymase secreted from mast cells in skin may affect the behavior of surrounding cells by the hydrolysis of PARs expressed by these cells...
- Protease-activated receptors: the role of cell-surface proteolysis in signallingGraeme S Cottrell
Department of Surgery, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
Essays Biochem 38:169-83. 2002..Therefore, selective antagonists or agonists of these receptors may be useful therapeutic agents for the treatment of human diseases...
- Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cellsNithiananthan Asokananthan
Division of Inflammation and Infectious Diseases, Department of Microbiology, Asthma and Allergy Research Institute, University of Western Australia, Nedlands, Western Australia, Australia
J Immunol 168:3577-85. 2002..Combined, these data suggest an important role for PAR in the modulation of inflammation in the lung...
- The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemiaCandice E Junge
Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 100:13019-24. 2003....
- The cytoprotective protein C pathwayLaurent O Mosnier
Department of Molecular and Experimental Medicine MEM 180, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
Blood 109:3161-72. 2007....
- Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cellsL Kamath
Division of Hematology/Oncology, Molecular Cardiology Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Cancer Res 61:5933-40. 2001..These findings suggest that therapeutics targeted toward G(i)-couplers that are selectively expressed in breast cancer cells could prove beneficial in halting the progression of invasive breast cancer...
- Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasisXiaoli Shi
Cancer Biology Division, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, San Diego, CA 92121, USA
Mol Cancer Res 2:395-402. 2004..Together, these data confirm a role for PAR1 in migration and metastasis and demonstrate an unexpected role for PAR2 in thrombin-dependent tumor cell migration and in metastasis...
- beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulationMay M Paing
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7365, USA
J Biol Chem 277:1292-300. 2002....
- Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitizationMay M Paing
Department of Pharmacology, University of North Carolina at Chapel Hill, 1106 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7365 USA
Mol Cell Biol 26:3231-42. 2006..Our findings establish a novel role for AP2 in direct regulation of PAR1 trafficking, a process critically important to the temporal and spatial aspects of thrombin signaling...
- Thrombin receptor expression is upregulated in prostate cancerVarsha Kaushal
Department of Internal Medicine, University of Arkansas for Medical Sciences, and Division of Hematology Oncology, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
Prostate 66:273-82. 2006..Aberrant expression of protease-activated receptors (PARs) has been associated with increased angiogenesis, tumor growth, and metastasis of various cancers. We assessed the status of PAR1 expression in prostate cancer...
- Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanomaDaniela Massi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Hum Pathol 36:676-85. 2005..Conversely, the significance of PAR-2 up-regulation in both benign and malignant melanocytic lesions requires further research...
- Cdc42 regulates the restoration of endothelial barrier functionPanos Kouklis
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Ill, USA
Circ Res 94:159-66. 2004..The delayed activation of Cdc42 represents a negative-feedback mechanism that signals AJ reassembly after the increase in endothelial permeability induced by inflammatory mediators such as thrombin...
- The pattern of expression of protease-activated receptors (PARs) during early trophoblast developmentSharona Cohen Even-Ram
Department of Oncology, Pathology, Hadassah University Hospital, Jerusalem, Israel
J Pathol 200:47-52. 2003..Together, our data suggest the involvement of PAR1 and PAR3 in restricted and unrestricted pathological trophoblast invasion...
- Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNAGabriel J Villares
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 68:9078-86. 2008..We propose that siRNA incorporated into DOPC nanoparticles could be delivered systemically and used as a new modality for melanoma treatment...
- Role and regulation of the thrombin receptor (PAR-1) in human melanomaCarmen Tellez
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 22:3130-7. 2003....
- The agonist of the protease-activated receptor-1 (PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cellsT Arisato
Department of Laboratory and Molecular Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
Cell Mol Life Sci 60:1716-24. 2003..Thus, our data show that thrombin caused VEGF release via PARI activation in a manner dependent on [Ca2+]i and p44/42 downstream from the receptor activation...
- Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancerAnika Agarwal
Molecular Oncology Research Institute, Tufts Medical Center, Box 7510, Boston, MA 02111, USA
Mol Cancer Ther 7:2746-57. 2008..These data provide an in vivo proof-of-concept that targeting the metalloprotease-PAR1 signaling system may be a novel therapeutic approach in the treatment of ovarian cancer...
- The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathwaysC B Martin
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina NC 27599-7295, USA
Oncogene 20:1953-63. 2001..Taken together, these observations suggest that PAR-1 growth transformation is mediated, in part, by activation of RhoA...
- PAR1 cleavage and signaling in response to activated protein C and thrombinMatthew J Ludeman
Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
J Biol Chem 280:13122-8. 2005..Although consistent with reports that sufficiently high concentrations of APC can cleave and activate PAR1 in culture, our data suggest that a significant physiological role for PAR1 activation by APC is unlikely...
- Thrombin/thrombin receptor (PAR-1)-mediated induction of IL-8 and VEGF expression in prostate cancer cellsJian Liu
University of Rostock, Institute of Clinical Chemistry and Laboratory Medicine, Ernst Heydemann Str 6, D 18057 Rostock, Germany
Biochem Biophys Res Commun 343:183-9. 2006..The results suggest that the thrombin/PAR-1 system upregulates cytokines in prostate cancer cells which in turn may contribute to the progression of prostate cancer...
- Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasionP Arora
Department of Pharmacology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Oncogene 27:4434-45. 2008..These studies reveal a critical role for PAR1, a receptor activated by tumor-generated proteases, in hyperactivation of ErbB signaling that promotes breast carcinoma cell invasion...
- Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alphaL Chi
Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160-7317, USA
J Interferon Cytokine Res 21:231-40. 2001..The results demonstrate significant potentiation of PAR-induced signaling by LPS and TNF-alpha and indicate the potential cooperation of proteases and inflammatory stimuli in amplifying vascular inflammation...
- PAR1 thrombin receptor-G protein interactions. Separation of binding and coupling determinants in the galpha subunitS Swift
Molecular Cardiology Research Institute, Division of Hematology, New England Medical Center, Boston, Massachusetts 02111, USA
J Biol Chem 275:2627-35. 2000....
- Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cellsTetsuzo Nakayama
Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Br J Pharmacol 138:121-30. 2003..05) attenuated by the preceding stimulation with thrombin but not trypsin. 5 In conclusion, trypsin cleaved PAR1 but did not activate it in the endothelial cells. Moreover, the trypsin-cleaved PAR1 was no longer responsive to thrombin...
- A role for thrombin receptor signaling in endothelial cells during embryonic developmentC T Griffin
Cardiovascular Research Institute, University of California at San Francisco UCSF, San Francisco, California 94143
Science 293:1666-70. 2001....
- Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1Joseph N McLaughlin
Department of Pharmacology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 280:25048-59. 2005..This model provides an estimate that peptide activation alters receptor/G protein binding to favor Galpha(q) activation over Galpha(12/13) by approximately 800-fold...
- Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissuesM R D'Andrea
Drug Discovery, The R W Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA
Am J Pathol 158:2031-41. 2001..PAR-1 and PAR-2 in the cells forming the tumor microenvironment suggest that these receptors mediate the signaling of secreted thrombin and trypsin in the processes of cellular metastasis...
- Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cellsHiroshi Kataoka
Cardiovascular Research Institute and Department of Medicine and Celluar and Molecular Pharmacology, University of California, San Francisco, 94143, USA
Blood 102:3224-31. 2003..These receptors serve at least partially redundant roles in endothelial cells in vitro and in vivo and together are necessary for the thrombin responses measured...
- Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladderMichael R D'Andrea
Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania, USA
Am J Pathol 162:907-23. 2003..It is timely to understand the role of tryptase signaling and PARs in the context of bladder biology...
- Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptorsSusan R Wilson
School of Pharmacy, Medical Biology Centre, Queens University Belfast, 97 Lisburn Road, Belfast, United Kingdom
Prostate 60:168-74. 2004..Protease-activated receptors (PARs) have previously been shown to be involved in pathways of MMP upregulation by tumor cells...
- Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombinM L Kahn
Cardiovascular Research Institute and Daiichi Research Center, University of California San Francisco, San Francisco, California 94143 0130, USA
J Clin Invest 103:879-87. 1999..These observations suggest that PAR1 and PAR4 account for most, if not all, thrombin signaling in platelets and that antagonists that block these receptors might be useful antithrombotic agents...
- Human protease-activated receptor 1 expression in malignant epithelia: a role in invasivenessYong Jun Yin
Department of Oncology, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel
Arterioscler Thromb Vasc Biol 23:940-4. 2003..PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands...
- Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthaseHiroyuki Suzuki
Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
Hypertension 53:182-8. 2009....
- Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout miceChristopher D Major
Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19477 0776, USA
Arterioscler Thromb Vasc Biol 23:931-9. 2003....
- Protease-activated receptors: sentries for inflammation?T M Cocks
Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia
Trends Pharmacol Sci 21:103-8. 2000..In this article, the ways in which the distribution and function of PARs could be harnessed by pharmacologists as novel anti-inflammatory therapeutic strategies are discussed...
- Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanismSteven Swift
Molecular Oncology Research Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 281:4109-16. 2006..This "7-8-1" interaction network was found to be prevalent in G protein-coupled receptors involved in endothelial signaling and angiogenesis...
- Protease-activated receptor stimulation activates a Ca2+-independent phospholipase A2 in bladder microvascular endothelial cellsAlice Rickard
Dept of Pathology, Saint Louis Univ School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
Am J Physiol Renal Physiol 288:F714-21. 2005....
- A role for proteinase-activated receptor-1 in inflammatory bowel diseasesNathalie Vergnolle
Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
J Clin Invest 114:1444-56. 2004....
- Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrinS C Even-Ram
Departments of Oncology and Pharmacology at the Hadassah Hebrew University Hospital, Jerusalem 91120, Israel, The Department of Hematology, Medical Center, Tel Aviv 64239, Israel
J Biol Chem 276:10952-62. 2001..We propose that the activation of PAR1 may lead to a novel cooperation with the alpha(v)beta(5) integrin that supports tumor cell invasion...
- Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cellsHua Tang
Department of Biochemistry, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
Blood 105:1977-85. 2005..Since TGF-beta plays a crucial role in the resolution phase of angiogenesis, the down-regulation of TGF-beta signaling by thrombin-PAR1 pathway may provide a new insight into the mechanism of the proangiogenic effect of thrombin...
- Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cellsMohammad Tauseef
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Circ Res 103:1164-72. 2008..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
- Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanismL de Garavilla
The R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA
Br J Pharmacol 133:975-87. 2001..In intact tissues, neurogenic mechanisms are predominantly responsible for PAR1-induced oedema...
- Characterization and functional activity of thrombin receptors in the human lensColin James
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
Invest Ophthalmol Vis Sci 46:925-32. 2005..To investigate the expression of thrombin receptors in the human lens, the activation of downstream signaling pathways, and the ability of thrombin to regulate lens cell growth...
- Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progressionZaidoun Salah
Department of Oncology, Hadassah Hebrew University Hospital, P O Box 12000, Jerusalem 91120, Israel
Mol Cancer Res 5:229-40. 2007..We conclude that whereas PAR1 gene expression correlates with tumor progression, its neutralization effectively initiates an apoptotic pathway leading at least in part to significantly reduced tumor formation...
- Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotectiveTong Cheng
Frank P Smith Neurosurgical Research Laboratory, Department of Neurosurgery and Center for Aging and Developmental Biology, Division of Neurovascular Biology, University of Rochester Medical Center, Rochester, New York, USA
Nat Med 9:338-42. 2003..9). Moreover, the in vivo neuroprotective effects of low-dose mouse APC seemed to be independent of its anti-coagulant activity. Thus, APC protects the brain from ischemic injury by acting directly on brain cells...
- Protease-activated receptors in inflammation, neuronal signaling and painN Vergnolle
Mucosal Inflammation Research Group, Dept of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Alberta, T2N 4N1, Calgary, Canada
Trends Pharmacol Sci 22:146-52. 2001..Thus, the list of potential roles for PARs has lengthened considerably and their physiological course of action might be much broader than initially anticipated...
- Protease-activated receptor 1: a role in prostate cancer metastasisTa Chun Yuan
Department of Biochemistry, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
Clin Prostate Cancer 3:189-91. 2004....
- A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalizationMay M Paing
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
J Biol Chem 279:21938-47. 2004..This study is the first to describe a function for a tyrosine-based motif, YXX, in GPCR internalization and reveal novel complexities in the regulation of GPCR trafficking...
- Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptidesLidija Covic
Molecular Cardiology Research Institute, Division of Hematology Oncology, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 99:643-8. 2002..Construction of such peptide-lipid conjugates constitutes a new molecular strategy for the development of therapeutics targeted to the receptor-effector interface...
- Phospholipid metabolite production in human urothelial cells after protease-activated receptor cleavageAlice Rickard
Department of Pathology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
Am J Physiol Renal Physiol 283:F944-51. 2002..Thus stimulation of PAR-1 or PAR-2 on HUR leads to iPLA(2)-catalyzed phospholipid hydrolysis, resulting in the production of metabolites that may mediate inflammation or provide cytoprotection to the bladder...
- Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samplesSorina Grisaru-Granovsky
Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
Int J Cancer 113:372-8. 2005..Altogether our data suggest that hPar1 and FAK cooperate to promote ovarian cancer malignancy...
- von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activationSandra Turcotte
Laboratoire de Medecine Moleculaire, Hopital Sainte Justine, Universite du Quebec a Montreal, Montreal, Quebec
Int J Cancer 112:777-86. 2004..Together, these results demonstrate that thrombin induces both pVHL expression via PAR1/RhoA activation as well as the stimulation of renal cancer cell invasion suggesting a role for thrombin in tumor invasion...
- Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathwaysXiaoling Deng
Centre for Respiratory Research, University College London, London WC1E 6JJ, United Kingdom
Mol Biol Cell 19:2520-33. 2008....
- New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biologyC Patterson
Program in Molecular Cardiology and Department of Medicine, Lineberger Comprehensive Cancer Center and Center for Thrombosis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7075, USA
Circ Res 88:987-97. 2001..In this review, we examine the activation of protease-activated receptors by thrombin, the downstream signaling events mediated by these receptors, and the physiological role of thrombin in vascular cells and vascular disease...
- Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout miceS M Vogel
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
Physiol Genomics 4:137-145. 2000..The results indicate that the PAR-1 receptor is critical in mediating the permeability-increasing and vasoconstrictor effects of thrombin in pulmonary microvessels...
- How the protease thrombin talks to cellsS R Coughlin
Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
Proc Natl Acad Sci U S A 96:11023-7. 1999..PAR2 is activated by trypsin and by trypsin-like proteases but not by thrombin. Recent studies with knockout mice, receptor-activating peptides, and blocking antibodies are beginning to define the role of these receptors in vivo...
- Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cellsMari Miki
Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine, Tokushima, Japan
J Med Invest 50:95-107. 2003..The Ca2+ response to HAT was desensitized by exposure of HBEC to PAR-2 AP. These results indicate that HBEC have a functional PAR-2, and HAT regulates cellular functions of HBEC via activation of PAR-2...
- Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cellsDionne R Morris
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7365, USA
Cancer Res 66:307-14. 2006....
- Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cellsRebecca A Houliston
Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, Royal College Street, London, UK
Thromb Haemost 88:321-8. 2002..These results demonstrate that regulation of COX-2 induction is an important functional response of HUVEC to PAR activation and suggest that PARs promote sustained upregulation of prostanoid production in human endothelium...
- Receptors of the PAR family as a link between blood coagulation and inflammationT N Dugina
Department of Human and Animal Physiology, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
Biochemistry (Mosc) 67:65-74. 2002..The presence of PAR receptors on mast cells is responsible for their reactivity to thrombin and factor Xa and defines their contribution to the association of inflammation and blood clotting processes...
- Participation of protease-activated receptor-1 in thrombin-induced microglial activationZhiming Suo
Neurobiology Research Laboratory, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
J Neurochem 80:655-66. 2002..In addition, strategies aimed at blocking thrombin signaling through PAR1 may be therapeutically valuable for diseases associated with cerebral vascular damage and significant inflammation with microglial activation...
- Mechanisms of action of proteinase-activated receptor agonists on human plateletsAda W Y Chung
Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
Br J Pharmacol 135:1123-32. 2002..11. Thus, the mechanisms of PAR1 and 4-induced platelet aggregation are distinct and depend differentially on their ability to interact with pathways of aggregation, along with the subsequent activation of GPIIb/IIIa receptors...
- Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signalingSoochong Kim
Department of Physiology and the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
Blood 99:3629-36. 2002....
- alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptorsR W Hauck
Pneumologie der 1 Medizinischen Klinik und Deutsches Herzzentrum, Technische Universitat, 81675 Munich, Germany
Am J Physiol 277:L22-9. 1999..Further studies are needed to determine whether alpha-thrombin plays a role in stimulating bronchoconstriction in inflammatory airway diseases such as asthma and bronchiolitis obliterans...
- Dual effect mediated by protease-activated receptors on the mechanical activity of rat colonFlavia Mulè
Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italy
Br J Pharmacol 136:367-74. 2002..PARs mediate changes of the mechanical activity of longitudinal and circular muscle which might explain the alterations of colonic motility observed during inflammatory conditions...
- Activation of endothelial cell protease activated receptor 1 by the protein C pathwayMatthias Riewald
Department of Immunology, C204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 296:1880-2. 2002..Thus, the prototypical thrombin receptor is the target for EPCR-dependent APC signaling, suggesting a role for this receptor cascade in protection from sepsis...
- Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteriesJustin R Hamilton
Department of Pharmacology, University of Melbourne, Victoria 3010, Australia
Br J Pharmacol 136:492-501. 2002....
- Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4Rithwik Ramachandran
Division of Cardiovascular and Respiratory Studies, Postgraduate Medical Institute of the University of Hull, Hull York Medical Schoo, East Yorkshire, UK
Am J Physiol Lung Cell Mol Physiol 292:L788-98. 2007..These findings point to an important mechanism, whereby cellular responses to thrombin and cathepsin-G can be modified during an inflammatory response...
- Effects of inhaled thrombin receptor agonists in miceJames D Moffatt
Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, Kings College London, 5th Floor Hodgkin Building, Guy s Campus, London SE1 9RT
Br J Pharmacol 143:269-75. 2004..In conclusion, exogenous thrombin has only a modest acute inflammatory action in the lung that appears to be mediated by PAR(4) and involve release of TNF-alpha from an unknown source...
- [The role of PAR family receptors in activation of mast cells in the norm and in acute inflammation in rats]E V Kiseleva
M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia
Ross Fiziol Zh Im I M Sechenova 87:1527-33. 2001..Acceleration of the mast cell mediator secretion by the Xa factor and PAR-2 agonist, was revealed. An increase in the mast cell release induced by thrombin and TRAP-6 was shown in the acute peritonitis model...
- Actin polymerisation regulates thrombin-evoked Ca(2+) signalling after activation of PAR-4 but not PAR-1 in human plateletsMatthew T Harper
Department of Physiology, University of Cambridge, Downing Street, Cambridge, UK
Platelets 17:134-42. 2006..These data suggest that Cyt D prevents the internalisation of PAR-4, which may lead to prolonged signalling from this receptor. This may mask a direct effect of Cyt D on the activation of SOCE after the activation of PAR-4...
- Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase IIMonique David-Dufilho
Department of Signalisation Cellulaire et Atherosclerose Precoce, Universite Paris 6 CNRS, Paris 75014, France
J Biol Chem 280:35999-6006. 2005..This signaling may contribute to thrombomodulin function in thrombosis, inflammation, and atherosclerosis...
- Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptorsYaowanuj Kirilak
School of Surgery and Pathology Orthopaedics, The University of Western Australia, Crawley WA 6009, Australia
Int J Mol Med 17:551-8. 2006..Together, these data demonstrate that FS supports both the migration and proliferation of human chondrocytes. We propose that these effects are mediated, at least in part, via thrombin-induced PAR-1 signalling in human chondrocytes...
- Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometryD Loew
Laboratoire de Spectrometrie de Masse Bio Organique, Universite Louis Pasteur, Strasbourg, France
Biochemistry 39:10812-22. 2000..This strategy provides results which can be extended to the native receptor to predict its activation or inactivation, and it could likewise be used to study other PARs or protease-dependent processes...
- The effects of stimulating protease-activated receptor-1 and -2 in A172 human glioblastomaT Okamoto
Department of Surgery I, Okayama University Medical School, Japan
J Neural Transm 108:125-40. 2001..The uni-directional cross desensitization implies a functional linkage between PAR-1 and PAR-2 receptors...
- Thrombin-stimulated growth, clustering, and collagen lattice contraction of human gingival fibroblasts is associated with its protease activityM C Chang
Team of Biomedical Science, Chang-Gung Institute of Nursing, Taoyuan, Taiwan
J Periodontol 72:303-13. 2001..The stimulatory effects of thrombin are associated with its protease activation of thrombin receptors...
- Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitroMichele Tognetto
Department of Experimental and Clinical Medicine, Pharmacology Unit, University of Ferrara, S Anna Hospital, via Fossato di Mortara 19, 44100 Ferrara, Italy
Br J Pharmacol 139:21-7. 2003..5. In agreement with the motor function data immunohistochemistry showed specific staining patterns for PAR-1 in the human renal artery. 6. Combined, these studies would suggest a possible role for PAR-1 in renal vascular homeostasis...
- Mechanism of trypsin-induced contraction in the rat myometrium: the possible involvement of a novel member of protease-activated receptorY Shintani
Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
Br J Pharmacol 133:1276-85. 2001..Trypsin was thus suggested to contract the rat myometrium via a novel type of PAR, which might be upregulated during pregnancy...
- Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinaseM Eto
Department of Cardiology, University Hospital, Institutes of Physiology, , Switzerland
Circ Res 89:583-90. 2001..These effects of thrombin may be important for endothelial dysfunction in cardiovascular disease, particularly during acute coronary episodes...
- Screening for allosteric modulators of the protease activated receptor 4Heidi E Hamm; Fiscal Year: 2013..These studies should provide valuable tool compounds which would have advantages of temporal and spatial specificity, becoming efficacious only when thrombin is present. ..
- Endothelial Myocyte Matrix in Cardiac RemodelingSuresh C Tyagi; Fiscal Year: 2013..PHS 398/2590 (Rev. 11/07) Page Continuation Format Page ..
- Optimization of PAR4 antagonists for thrombotic disordersHeidi E Hamm; Fiscal Year: 2013..These studies should provide a valuable tool compound which will enable studies that may reveal PAR4 as an alternative target for preventive and therapeutic suppression of pathologic thrombus formation. ..
- Mitophagic and anti-angiogenic mechanism of heart failureSuresh C Tyagi; Fiscal Year: 2013..The positive outcome of this project will have therapeutic ramifications for chronic heart failure. ..
- Endothelial Dysfunction in Intestinal Radiation ToxicityMartin Hauer Jensen; Fiscal Year: 2009..This project may thus facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
- TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAYWolfram Ruf; Fiscal Year: 2007..abstract_text> ..
- PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSISWolfram Ruf; Fiscal Year: 2010..3. ..
- Thrombin,Sepsis and Mechanisms of InflammationChinnaswamy Tiruppathi; Fiscal Year: 2010..It is hoped that this work will lead to the development of new drug targeting acute lung injury associated with leaky lung microvessel and tissue edema formation. ..
- Urothelial Cell Physiology in Normal and Disease StatesRicardo Saban; Fiscal Year: 2005..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
- LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATIONRicardo Saban; Fiscal Year: 2007..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
- Bladder transcriptome in experimental inflammationRicardo Saban; Fiscal Year: 2007..Following target validation of SSH-selected genes, a custom array will be developed. This micro array will be used to determine how the bladder transcriptome is altered by BCG therapy. ..
- PKD Family Kinases and Idiopathic Pulmonary FibrosisHua Tang; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- MMPs and Synaptic Injury with HIV/METHKatherine Conant; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Role of Plasminogen in ApoptosisJennifer Mitchell; Fiscal Year: 2005..This hypothesis is based on preliminary results, which demonstrate that the addition of plasminogen to monocytes significantly impedes apoptosis. ..
- Myocyte signaling and the response to stressWINSTON PATTERSON; Fiscal Year: 2009....
- Carolina Cardiopulmonary Gene Expression ServicesWINSTON PATTERSON; Fiscal Year: 2005..abstract_text> ..
- Platelet Membrane Proteins in ThrombosisSusan Smyth; Fiscal Year: 2005..This work will identify a novel target for future antithrombotic strategies and challenge the assumption that the beneficial effects of P-selectin antagonists are exclusive to leukocytes. ..
- MECHANISM OF HUMAN MAST CELL TRYPTASE REGULATIONNorman Schechter; Fiscal Year: 2003..Understanding the structural properties responsible for the functional instability may provide new targets for therapeutic inhibitors. ..
- Thrombin signaling and HIV dementiaKatherine Conant; Fiscal Year: 2006..abstract_text> ..
- The biology of Ron, the HGF-like protein receptorSANDRA DEGEN; Fiscal Year: 2004....
- Tissue Factor-factor Vlla signalingUsha Pendurthi; Fiscal Year: 2010..The proposed studies will provide valuable information in understanding how TF contributes to tumorigenesis. These studies will also provide clues on potential therapeutic targets for prevention of cancer progression. ..
- CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIAJohn E Baker; Fiscal Year: 2010..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
- MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITYAlireza R Rezaie; Fiscal Year: 2010....
- Epithelial Innate Immune Response to Oral BacteriaWHASUN CHUNG; Fiscal Year: 2008..This work will lay the groundwork for identifying new therapeutic targets to prevent and treat periodontal diseases. [unreadable] [unreadable]..
- REGULATION OF PLATELET SHAPE CHANGESJohn Hartwig; Fiscal Year: 2008..abstract_text> ..
- Radiation injury to the heartJohn E Baker; Fiscal Year: 2010..1 ..
- Mast Cell-Induced Inflammation in Vascular DiseaseKottarappat N Dileepan; Fiscal Year: 2010..abstract_text> ..
- Regulation of Beta-Defensin Expression in Oral EpitheliaWHASUN CHUNG; Fiscal Year: 2009..These studies will lead to new insights on the role of innate immunity and new potential targets for therapeutic drug development for oral infections. ..
- SERINE PROTEASES FROM MAST CELLS AND SKINNorman Schechter; Fiscal Year: 2002..It is hoped that these studies will advance our understanding of two classes of molecules which are important to production and regulation of inflammation. ..
- GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIAJohn Baker; Fiscal Year: 2003....
- Alpha2-Macroglobulin-PA Complexes: Novel Anthrax Vaccin*SALVATORE PIZZO; Fiscal Year: 2003..These studies will provide a new anthrax vaccine candidate with both improved immunogenicity and decreased reactogenicity. ..
- Aging, Stress and AtherosclerosisWINSTON PATTERSON; Fiscal Year: 2003..Based on these studies, we will create molecular portraits of the ROS-dependent and ROS-independent transcripts preferentially associated with aging. ..
- PROTEASE-ACTIVATED RECEPTOR ACTIONS IN CARDIOMYOCYTESSusan Steinberg; Fiscal Year: 2004....
- HIV 1 PROTEINS AND DRUGS OF ABUSE AND METALLOPROTEASESKatherine Conant; Fiscal Year: 2003..We will also examine the mechanisms by which these substances may affect MMP production, and identify clinically tolerable compounds which may inhibit such production. ..
- Tyrosine Phosphatases and Endothelial DysfunctionHua Tang; Fiscal Year: 2004..abstract_text> ..
- Molecular Mechanisms of PAR1 DownregulationJoAnn Trejo; Fiscal Year: 2005..Thus we will use the C-tail of PAR1 as a probe in protein-protein interaction based strategies to identify new molecules that recognize and sort PAR1 to lysosomes...
- ACTIVATED ENDOTHELIAL ADHESIVITY IN SC VASOOCCLUSIONStephen Embury; Fiscal Year: 2003..They may provide the basis for future therapeutic interventions. ..
- CELL RECEPTORS IN COAGULATION AND ATHEROGENESISSALVATORE PIZZO; Fiscal Year: 2006..Future studies will determine whether this pathway also is essential for alpha2M-antigen processing and presentation. ..
- Regulation of Human Beta-Defensins in EpitheliaWHASUN CHUNG; Fiscal Year: 2006..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
- MMPs in neural networkingKatherine Conant; Fiscal Year: 2006..The results of our studies should improve our understanding of those CNS inflammatory diseases that are characterized by elevated levels of MMPs. [unreadable] [unreadable] [unreadable]..
- PI3K in LPS-induced coagulation and inflammationJames Luyendyk; Fiscal Year: 2006..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. [unreadable] [unreadable] [unreadable]..
- Localization and activation of protease receptor PAR1CANDICE JUNGE; Fiscal Year: 2002..Because tPA is currently approved for stroke, these studies may lead to a possible adjunct therapy that enhances tPA?s beneficial effects. ..
- b1-/b2-Adrenergic Receptor Mechanisms in CardiomyocytesSusan Steinberg; Fiscal Year: 2007..As such, these studies are likely to suggest novel clinical strategies that might be pursued (or should be avoided) for the management of chronic heart failure in humans. ..
- MMPS IN HIV DEMENTIA: EFFECTS ON BBB STRUCTURE/FUNCTIONKatherine Conant; Fiscal Year: 2003..Also, the proposed studies will use both primary brain-derived HIV isolates, which differ from laboratory adapted strains, and normal human cells, which also differ significantly from those of rodent or tumor origin. ..
- Diabetes, Inflammation and Vascular DiseaseSusan Smyth; Fiscal Year: 2004..Moreover, our results may have broad implications for the treatment and prevent of accelerated atherosclerosis and thrombosis in diabetes. ..
- Modulation of Angiogenesis Via the Angiostatin ReceptorSALVATORE PIZZO; Fiscal Year: 2005..Because of the exposed intravascular localization of the ATP synthesizing enzymes, this project will yield a collection of anti-angiogenic compounds with strong potential for rapid translation into clinical studies. ..
- Microglial Cell Activation by Thrombin in StrokeJonathan Weinstein; Fiscal Year: 2008..unreadable] [unreadable]..
- Integrin Signaling In Vascular CellsSusan Smyth; Fiscal Year: 2009..abstract_text> ..