cd40 ligand

Summary

Summary: Membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. It binds to CD40; (ANTIGENS, CD40) on B-cells, inducing B-cell proliferation. Mutation in this protein causes X-linked hyper-IMMUNOGLOBULIN M syndrome (HYPERGAMMAGLOBULINEMIA).

Top Publications

  1. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
  2. pmc Molecular mechanism and function of CD40/CD40L engagement in the immune system
    Raul Elgueta
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Immunol Rev 229:152-72. 2009
  3. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
  4. pmc miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells
    Shaun Willimott
    Department of Cancer Studies and Molecular Medicine and MRC Toxicology Unit, University of Leicester, Leicester LE19HN, United Kingdom
    J Biol Chem 287:2608-17. 2012
  5. ncbi Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
    Marco Frentsch
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Nat Med 11:1118-24. 2005
  6. pmc Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells
    Sonia Feau
    Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:908-13. 2011
  7. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
  8. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
  9. ncbi The CD40/CD154 receptor/ligand dyad
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:4-43. 2001
  10. ncbi Platelet-derived CD40L: the switch-hitting player of cardiovascular disease
    Patrick Andre
    Circulation 106:896-9. 2002

Detail Information

Publications369 found, 100 shown here

  1. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ....
  2. pmc Molecular mechanism and function of CD40/CD40L engagement in the immune system
    Raul Elgueta
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Immunol Rev 229:152-72. 2009
    ..Lastly, we discuss the role of CD40 as a target in harnessing anti-tumor immunity. This review underscores the essential role CD40 plays in adaptive immunity...
  3. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    ....
  4. pmc miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells
    Shaun Willimott
    Department of Cancer Studies and Molecular Medicine and MRC Toxicology Unit, University of Leicester, Leicester LE19HN, United Kingdom
    J Biol Chem 287:2608-17. 2012
    ..We previously showed that a stromal cell/CD40 ligand (CD154) culture system reproduced this switch in survival protein expression in primary human leukemic B-cells ..
  5. ncbi Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
    Marco Frentsch
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Nat Med 11:1118-24. 2005
    ....
  6. pmc Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells
    Sonia Feau
    Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:908-13. 2011
    ..Our findings reconcile contradictory elements implicit in each model noted above by showing that CD4(+) T cells activate APCs through a CD40L-dependent mechanism to enable autocrine production of IL-2 in CD8(+) memory T cells...
  7. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
    ....
  8. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    ..These results identify a 'combinatorial code' by which DCs discriminate pathogens and suggest new strategies for promoting T helper type 1 responses...
  9. ncbi The CD40/CD154 receptor/ligand dyad
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:4-43. 2001
    ....
  10. ncbi Platelet-derived CD40L: the switch-hitting player of cardiovascular disease
    Patrick Andre
    Circulation 106:896-9. 2002
  11. pmc CD40 and autoimmunity: the dark side of a great activator
    Anna L Peters
    Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Semin Immunol 21:293-300. 2009
    ..This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy...
  12. ncbi The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
    Taishin Akiyama
    Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Immunity 29:423-37. 2008
    ..These results show that developmental-stage-dependent cooperation between RANK and CD40 promotes mTEC development, thereby establishing self-tolerance...
  13. pmc Optimizing dendritic cell-based immunotherapy in multiple myeloma: intranodal injections of idiotype-pulsed CD40 ligand-matured vaccines led to induction of type-1 and cytotoxic T-cell immune responses in patients
    Qing Yi
    Department of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Br J Haematol 150:554-64. 2010
    ..of DC vaccination in myeloma, we investigated the use of Id- and keyhole limpet haemocyanin (KLH)-pulsed, CD40 ligand-matured DCs administered intranodally...
  14. ncbi A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles
    Pratip K Chattopadhyay
    Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, 40 Convent Drive, Room 5509, Bethesda, Maryland 20892, USA
    Nat Med 11:1113-7. 2005
    ..For vaccine- or pathogen-specific responses, we found substantial heterogeneity in expression of CD154 and cytokines, suggesting previously unrecognized diversity in abilities of responding cells to stimulate APCs through CD40...
  15. ncbi CD40-CD40L and platelet function: beyond hemostasis
    Jane E Freedman
    Circ Res 92:944-6. 2003
  16. ncbi Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    J Tan
    The Roskamp Institute, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613, USA
    Science 286:2352-5. 1999
    ..alpha production and induction of neuronal injury occurred when Abeta-stimulated microglia were treated with CD40 ligand (CD40L)...
  17. pmc CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    A D Kirk
    Division of Transplantation, University of Wisconsin Hospital, Madison, WI 53792, USA
    Proc Natl Acad Sci U S A 94:8789-94. 1997
    ....
  18. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..CCR7, which allows them to localize to B cell follicles and germinal centers where they express high levels of CD40 ligand (CD40L), a costimulatory molecule required for B cell activation and inducible costimulator (ICOS), a recently ..
  19. ncbi A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Christine Bourgeois
    INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
    Science 297:2060-3. 2002
    The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation...
  20. ncbi CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke
    Giovanni Davi
    Department of Medicine and Aging, G d Annunzio University School of Medicine, Chieti, Italy
    J Atheroscler Thromb 16:707-13. 2009
    Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia...
  21. pmc A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
    Mark Melchers
    Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Netherlands
    Retrovirology 8:48. 2011
    ..We have previously stabilized soluble trimeric mimics of Env by introducing a disulfide bond between gp120 and gp41 and adding a trimer stabilizing mutation in gp41 (SOSIP.R6 gp140)...
  22. ncbi The CD40-CD40L system in cardiovascular disease
    Burak Pamukcu
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, England UK
    Ann Med 43:331-40. 2011
    ..In this review, we provide an overview of potential implications of CD40-CD40L signalling and sCD40L as a biomarker in patients with atherosclerotic vascular diseases...
  23. ncbi Antiretroviral therapy reduces markers of endothelial and coagulation activation in patients infected with human immunodeficiency virus type 1
    Katja Wolf
    Basel Center for HIV Research, Outpatient Department of Internal Medicine, University Hospital Basel, Switzerland
    J Infect Dis 185:456-62. 2002
    ..Therapy did not reduce levels of the soluble platelet (sP) activation markers sP-selectin and CD40 ligand. The inhibition of markers of vascular activation may counterbalance sequelae of therapy-induced dyslipidemia ..
  24. pmc Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role
    Jianping Huang
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:3030-8. 2012
    ..In this study, we showed that an extracellular portion of a membrane-bound ligand of CD40 (soluble CD40 ligand; sCD40L) was significantly elevated in the serum of cancer patients compared with healthy donors...
  25. ncbi CD40 signaling and plaque instability
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:1092-103. 2001
    ..Recent work has documented overexpression of the potent immune mediator CD40 and its counterpart CD40 ligand (CD40L) in experimental and human atherosclerotic lesions...
  26. ncbi CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2
    Cristiana Guiducci
    Immunotherapy and Gene Therapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Eur J Immunol 35:557-67. 2005
    ..Such IL-2 effect is transient since T reg number returns to the low constitutive level described in CD40KO mice within 5 days upon IL-2 withdrawal thus suggesting that IL-2 is persistently needed to assure T reg homeostasis...
  27. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    ..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
  28. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  29. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis...
  30. ncbi Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998
    ..These data support the involvement of inflammatory pathways in atherosclerosis and indicate a role for CD40 signalling during atherogenesis in hyperlipidaemic mice...
  31. pmc Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    Amrie C Grammer
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:1506-20. 2003
    ....
  32. ncbi Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    S Han
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Immunol 155:556-67. 1995
    ..compared the roles of CD40L and B7-2 in the initiation and maturation of humoral immunity by administering anti-CD40 ligand (L) or anti-B7-2 Ab during the early (days -1 to 3) or late (days 6-10) phases of primary responses to thymus-..
  33. pmc Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells
    Changyi Chen
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Blood 112:3205-16. 2008
    ....
  34. ncbi CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease
    Muhammad Rizvi
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Mol Med 14:530-8. 2008
    b>CD40 ligand (CD40L) and its receptor CD40 participate in numerous inflammatory pathways that contribute to multiple pathophysiological processes...
  35. ncbi The CD40/CD40 ligand system: linking inflammation with atherothrombosis
    Charalambos Antoniades
    1st Department of Cardiology, University of Athens Medical School, Athens, Greece
    J Am Coll Cardiol 54:669-77. 2009
    The role of CD40/CD40 ligand (CD40L) in atherothrombosis is now widely accepted...
  36. pmc CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
    Giandomenica Iezzi
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:876-81. 2009
    ..vitro systems, we have investigated the role of antigen dose, pathogen-associated molecular patterns, and CD40-CD40 ligand (CD40L) cross-talk in Th17 differentiation...
  37. ncbi Mice deficient for the CD40 ligand
    J Xu
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510
    Immunity 1:423-31. 1994
    ..In summary, our study confirms the important role of CD40-CD40L interactions in thymus-dependent humoral immune responses and germinal center formation...
  38. ncbi IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: disruption of both IL-12-dependent and -independent pathways of IFN-gamma production
    John F McDyer
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:2736-46. 2002
    ..As T cell-dependent induction of IL-12 is regulated via CD40/CD40 ligand (CD40L) interactions, we examined the effect of HAT on CD40L expression...
  39. ncbi Soluble CD40 ligand in acute coronary syndromes
    Christopher Heeschen
    c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina CAPTURE Study, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    N Engl J Med 348:1104-11. 2003
    b>CD40 ligand is expressed on platelets and released from them on activation...
  40. ncbi TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
    Katia Schlienger
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 9:1517-27. 2003
    ..We also sought to measure preexisting antitumor immunity in patients with advanced ovarian cancer...
  41. pmc Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders
    Donna C Davidson
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    PLoS ONE 7:e51793. 2012
    ....
  42. ncbi Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering
    J M Tromp
    Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Oncogene 29:5071-82. 2010
    ..Thus, a distinction in NF-kappaB activation and drug susceptibility in mutated versus unmutated (LN-like) CLL cells was uncovered, which was causally linked to Bcl-X(L) levels...
  43. ncbi Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 178:1759-66. 2007
    ..stimulants including TLR agonists, in this study we investigated the capacity of IFN-gamma and the CD40 ligand (CD40L) to affect the expression and function of mFPR2...
  44. ncbi Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
    I S Grewal
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 378:617-20. 1995
    Lack of functional expression of CD40 ligand (CD40L) on T cells results in hyper-IgM syndrome (HIGM1), a human immunodeficiency associated with a severely impaired humoral immune response that is consistent with defects in B-cell ..
  45. pmc CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury
    Zifang Song
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, LSU Health Science Center in Shreveport, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e23239. 2011
    ..Our findings firmly established the role for CD40 in neointima formation in 2 distinct injury models...
  46. ncbi Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154
    L E Haswell
    Tenovus Research Laboratory, Cancer Sciences Division, The School of Medicine, University of Southampton, Southampton General Hospital, Southampton, GB
    Eur J Immunol 31:3094-100. 2001
    We describe the construction of a novel soluble dodecameric form of CD154 (CD40 ligand) that is more effective than trimeric tCD154 in triggering B cell activation...
  47. ncbi Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling
    Khawaja Ashfaque Ahmed
    Research Unit, Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan Canada
    J Leukoc Biol 92:289-300. 2012
    ....
  48. ncbi Plasma matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-2, and CD40 ligand levels in patients with stable coronary artery disease
    Muzahir H Tayebjee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 96:339-45. 2005
    ..In addition, high levels of the soluble fragment of CD40 ligand (sCD40L) have previously been associated with adverse cardiovascular outcomes...
  49. pmc Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals
    Donna C Davidson
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 186:584-91. 2011
    ....
  50. pmc Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interaction
    Norbert Donhauser
    Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 7:e33925. 2012
    ..the peripheral IFN-alpha production in HIV-1 infection is actively suppressed by the enhanced interaction of CD40 ligand (CD40L), a member of the tumor necrosis factor family, and its receptor CD40, which are both upregulated upon ..
  51. ncbi CD154 (CD40 ligand)-deficient mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregates
    A R Crow
    J Thromb Haemost 1:850-2. 2003
  52. ncbi Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures
    D Van Hemelen
    Laboratory of Allergology and Pulmonary Diseases, Dept Pathology and Medical Biology, University Medical Center of Groningen, GRIAC Research Institute, University of Groningen, The Netherlands
    J Immunol Methods 371:114-21. 2011
    ..Since this T(H) cell-population only accounts for a small percentage of T(H) cells, they are difficult to phenotype without prior selection or expansion...
  53. ncbi The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell memory
    Qigui Yu
    Clinical Sciences Division and St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Immunol 172:6047-56. 2004
    Mature dendritic cells (DCs) are central to the development of optimal T cell immune responses. CD40 ligand (CD40L, CD154) is one of the most potent maturation stimuli for immature DCs...
  54. ncbi A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation
    D Graf
    Robert Koch Institute, Berlin, Germany
    Eur J Immunol 25:1749-54. 1995
    ..Like other members of the TNF superfamily (e.g. TNF-alpha, Fas/APO-1 ligand), TRAP thus has the potential to be biologically active not only in a transmembrane form but also as a soluble molecule...
  55. ncbi gp91phox-dependent expression of platelet CD40 ligand
    P Pignatelli
    Divisione IV Clinica Medica, Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Policlinico Umberto I, 00185, Rome, Italy
    Circulation 110:1326-9. 2004
    b>CD40 ligand (CD40L) expression on platelets is mediated by agonists, but the underlying mechanism is still unclear.
  56. ncbi Soluble CD40L levels are regulated by the -3459 A>G polymorphism and predict myocardial infarction and the efficacy of antithrombotic treatment in non-ST elevation acute coronary syndrome
    Anders Malarstig
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, S 751 85 Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 26:1667-73. 2006
    ..The aim was to investigate the prognostic importance of soluble (s) CD40L levels, single nucleotide polymorphisms (SNP) in the CD40LG gene, and the relation between sCD40L and SNPs in patients with acute coronary syndromes (ACS)...
  57. ncbi Conservation of biological properties of the CD40 ligand, CD154 in a non-mammalian vertebrate
    Clive A Tregaskes
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Dev Comp Immunol 29:361-74. 2005
    Signals delivered by the CD40 ligand, CD154, have crucial roles in immune responses in mammals, being required for development of germinal centres, maturation of T-dependent antibody responses, and generation of B-cell memory...
  58. pmc CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury
    Xiuda Shen
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hepatology 50:1537-46. 2009
    ..IR triggered a significant liver increase in CD40 expression but not CD154 expression, and macrophages responded to toll-like receptor 4 and type I IFN stimulation to up-regulate CD40 expression...
  59. pmc Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
    Hajir Dadgostar
    Molecular Biology Institute and Medical Scientist Training Program, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:1497-502. 2002
    ....
  60. ncbi From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 115 28 Athens, Greece
    Trends Cardiovasc Med 20:153-64. 2010
    The binding of CD40 ligand (CD40L) to CD40 stimulates inflammatory processes including the release of proinflammatory cytokines and the expression of adhesion molecules implying a role in atherosclerosis...
  61. pmc Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    U Schonbeck
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7458-63. 2000
    ..Recently, we and others have implicated the immune mediator dyad CD40/CD40L (CD40 ligand), which is expressed on endothelial and smooth muscle cells, macrophages, and T lymphocytes within human ..
  62. pmc T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue
    David R Withers
    B Cell Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 109:4856-64. 2007
    ..In addition, an important role for contact-dependent interactions with T cells in human plasma cell survival within secondary lymphoid tissue was identified...
  63. ncbi Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome
    Junhong Wang
    Cardiovascular Research Center, Division of Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, PRC
    Int J Cardiol 115:361-5. 2007
    ..To investigate whether patients with acute coronary syndrome (ACS) possessed high levels of platelet-monocyte aggregates (PMAs) and related circulating biomarkers...
  64. ncbi Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells
    M L Albert
    Laboratory of Neuro Oncology, The Rockefeller University, 1230 York Avenue, Box 26, New York, NY 10021, USA
    Nat Immunol 2:1010-7. 2001
    ....
  65. pmc Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation
    Hyun Jung An
    Department of Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejon, Korea
    J Biol Chem 286:11226-35. 2011
    ..These findings suggest that ligand-induced di- or trimerization is necessary but not sufficient for complete activation of CD40...
  66. ncbi Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway
    Daniel Yacoub
    Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 30:2424-33. 2010
    b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
  67. ncbi Coordinating development of medullary thymic epithelial cells
    Mingzhao Zhu
    The Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:386-8. 2008
    ..2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells...
  68. ncbi Growth inhibition of human multiple myeloma cells by an oncolytic adenovirus carrying the CD40 ligand transgene
    Margret S Fernandes
    Cancer Immunology Research Laboratory, Baylor Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
    Clin Cancer Res 15:4847-56. 2009
    The growth-inhibitory activity of recombinant CD40 ligand (CD40L) is well documented in human multiple myeloma (MM). We examined MM-targeted delivery of CD40L by a conditional replicative oncolytic adenovirus, AdEHCD40L.
  69. pmc Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: helper role of CD8+ T cells in the development of T helper type 1 responses
    Robbie B Mailliard
    Department of Surgery, Cancer Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Exp Med 195:473-83. 2002
    ....
  70. ncbi CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathway
    Lata Mukundan
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cell Signal 16:375-84. 2004
    The interaction between CD40 ligand (CD154) expressed on activated T cells and its receptor, CD40, has been shown to play a role in the onset and maintenance of autoimmune inflammation...
  71. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..levels of IL-18 receptor (R)alpha chain and produce significant amounts of IL-4, IL-9, and IL-13, and induce CD40 ligand expression in response to IL-2 and IL-18 stimulation in vitro...
  72. ncbi Antitumor activity of an oncolytic adenoviral-CD40 ligand (CD154) transgene construct in human breast cancer cells
    Erica M Gomes
    Cancer Immunology Research Laboratory and Department of Pathology, Baylor Sammons Cancer Center, Dallas, TX 75246, USA
    Clin Cancer Res 15:1317-25. 2009
    b>CD40 ligand (CD40L, CD154) plays a central role in immunoregulation and also directly modulates epithelial cell growth and differentiation...
  73. ncbi Absence of CD40 signaling is associated with an increase in intimal thickening after arterial injury
    M Remskar
    Division of Cardiology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, California, USA
    Circ Res 88:390-4. 2001
    Immune-mediator CD40 ligand is expressed on a variety of cell types involved in the immune response and on the cells of the vascular system...
  74. ncbi A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    Dimitrios T Boumpas
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Arthritis Rheum 48:719-27. 2003
    CD40-CD40 ligand (CD40L) interactions play a significant role in the production of autoantibodies and tissue injury in lupus nephritis...
  75. ncbi The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
    A Aruffo
    Bristol Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121
    Cell 72:291-300. 1993
    ..The gene encoding gp39 was mapped to Xq26, the X chromosome region where the gene responsible for HIM had previously been mapped. These data suggest that a defect in gp39 is the basis of X-linked HIM...
  76. ncbi Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
    Jun Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Nat Neurosci 5:1288-93. 2002
    ..These findings suggest several possible mechanisms underlying mitigation of AD pathology in response to CD40L depletion, and validate the CD40-CD40L interaction as a target for therapeutic intervention in AD...
  77. ncbi Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
    I S Grewal
    Howard Hughes Medical Institute, and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 273:1864-7. 1996
    The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4(+) T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell ..
  78. ncbi Properties of CD4(+) T cells in human cytomegalovirus infection
    Laila E Gamadia
    Laboratory for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Hum Immunol 65:486-92. 2004
    ....
  79. ncbi Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia
    Jacqueline M Tromp
    Departments of Hematology and Experimental Immunology, and Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Cancer Res 18:487-98. 2012
    ..We aimed to define which antiapoptotic proteins determine resistance to ABT-737 in CLL and whether combination of known antileukemia drugs and ABT-737 was able to induce apoptosis of CD40-stimulated CLL cells...
  80. pmc Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation
    Lelia Delamarre
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520 8002, USA
    J Exp Med 198:111-22. 2003
    ..Thus, the MHC I and MHC II pathways of antigen presentation are differentially regulated during DC maturation...
  81. ncbi Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand
    Vijender R Vaidyula
    Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Diabetes 55:202-8. 2006
    ..2, factor VIII coagulant activity, and platelet CD40 ligand as well as decreases in factor VIIa, factor VII coagulant activities, and factor VII antigen...
  82. pmc T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus
    Ying Zhou
    Department of Dermatology and Epigenetic Research Center, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China
    Clin Immunol 132:362-70. 2009
    b>CD40 ligand (CD40LG), encoded on the X chromosome, has been reported to be overexpressed on lupus T cells...
  83. pmc Levels of soluble CD40 ligand (CD154) in serum are increased in human immunodeficiency virus type 1-infected patients and correlate with CD4(+) T-cell counts
    Nikolaos V Sipsas
    Department of Pathophysiology, Laikon General Hospital and School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Clin Diagn Lab Immunol 9:558-61. 2002
    b>CD40 ligand (CD40L or CD154) is a costimulatory molecule expressed mainly on activated CD4(+) T cells...
  84. ncbi ICOS is critical for CD40-mediated antibody class switching
    A J McAdam
    Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 409:102-5. 2001
    ..Class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway...
  85. ncbi CD40/CD40L signaling and its implication in health and disease
    Antonios Chatzigeorgiou
    Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Biofactors 35:474-83. 2009
    ..The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and ..
  86. pmc Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis
    F Mach
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:1931-6. 1997
    Increasing evidence supports involvement of inflammation and immunity in atherogenesis. We report here that CD40 ligand (CD40L), an immunoregulatory signaling molecule heretofore considered largely restricted to recently activated CD4+ T ..
  87. ncbi The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes
    M Poggi
    Faculte de Medecine, INSERM U626, Marseille Cedex 5, France
    Diabetologia 52:1152-63. 2009
    ..The CD40 molecule, TNF receptor superfamily member 5 (CD40)/CD40 ligand (CD40L) pathway plays a role in the onset and maintenance of the inflammatory reaction, but has not been ..
  88. pmc Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury
    Samina Yasmin Khan
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 108:2455-62. 2006
    ..Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammatory mediator that accumulates during platelet storage...
  89. ncbi Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy
    Francesco Cipollone
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 106:399-402. 2002
    Hypercholesterolemia is associated with inflammation and the prothrombotic state. CD40-CD40 ligand (CD40L) interactions promote a prothrombotic response in nucleated cells...
  90. pmc BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases...
  91. ncbi Ligation of E-cadherin on in vitro-generated immature Langerhans-type dendritic cells inhibits their maturation
    E Riedl
    Vienna International Research Cooperation Center Novartis Research Institute, Austria
    Blood 96:4276-84. 2000
    ..E-cadherin-mediated LC maturation suppression may represent a constitutive active epithelial mechanism that prevents the uncontrolled maturation of immature LCs. (Blood. 2000;96:4276-4284)..
  92. ncbi The multi-functionality of CD40L and its receptor CD40 in atherosclerosis
    Dirk Lievens
    Department of Pathology, University of Maastricht, 6229 HX Maastricht, The Netherlands
    Thromb Haemost 102:206-14. 2009
    ..In this review, we highlight the cell-type specific multi-functionality of CD40-CD40L signalling in atherosclerosis...
  93. ncbi TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    Several lines of evidence implicate CD40 ligand (CD40L, CD154) as a mediator and marker of atherosclerosis...
  94. ncbi CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
    R C Allen
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 259:990-3. 1993
    ..Thus, these CD40L defects lead to a T cell abnormality that results in the failure of patient B cells to undergo immunoglobulin class switching...
  95. pmc CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    Mol Cell Biol 20:5503-15. 2000
    ..Using a trimeric recombinant soluble CD40 ligand to activate CD40, we have found that this phenomenon critically depends on the membrane proximal domain (amino ..
  96. ncbi In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells
    T Hoshino
    Laboratory of Experimental Immunology, DBS, NCI FCRDC, Frederick, USA
    Eur J Immunol 30:1998-2006. 2000
    ..IL-18 can rapidly induce CD40 ligand (CD154) mRNA and surface expression on CD4+ but not CD8+ T cells...
  97. pmc Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
    Esther Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht 6200 MD, Netherlands
    J Exp Med 207:391-404. 2010
    The CD40-CD40 ligand (CD40L) signaling axis plays an important role in immunological pathways. Consequently, this dyad is involved in chronic inflammatory diseases, including atherosclerosis...
  98. ncbi Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice
    Liza Robles-Carrillo
    Center for Thrombosis Research, Florida Hospital, Orlando, FL 32804, USA
    J Immunol 185:1577-83. 2010
    ..This molecular mechanism may be important for understanding thrombosis associated with CD40L immunotherapy. The FCGR2A mouse model may also be useful for assessing the hemostatic safety of other therapeutic Abs...
  99. ncbi Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children
    Wenwei Tu
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 172:3260-7. 2004
    ..CD4(+) T cells from children also had reduced CMV-specific IL-2 and CD154 (CD40 ligand) expression, suggesting an early blockade in the differentiation of viral-specific CD4(+) T cells...
  100. ncbi Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    A Krug
    Department of Internal Medicine and Division of Clinical Pharmacology, University of Munich, Munich, Germany
    Eur J Immunol 31:3026-37. 2001
    ..b>CD40 ligand (CD40L) and CpG ODN synergized to activate PDC and to stimulate the production of IFN-alpha and IL-12 including ..
  101. ncbi Functions of CD40 on B cells, dendritic cells and other cells
    C van Kooten
    Department of Nephrology, Leiden University Hospital, 1 C3P, Albinusdreef 2, 2333 AA, Leiden, The Netherlands
    Curr Opin Immunol 9:330-7. 1997
    ..Furthermore, it has been established that ligation of CD40 ligand (CD40L) delivers signals to the CD40L bearing cells themselves...

Research Grants65

  1. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..additional source of OPG in vivo, and that B cell OPG production is regulated by costimulatory signals such as CD40 Ligand (CD40L) derived from T cells...
  2. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum amyloid A, MMP-9, E-selectin, P-selectin, CD40 ligand, fibrinogen, von Willebrand factor, and D-dimer)...
  3. Manipulation of Follicular Helper T Cells in Immunity and Autoimmunity
    Joseph Craft; Fiscal Year: 2013
    ..In GCs, T follicular helper (Tfh) cells provide B cells with survival and differentiation signals, including CD40 ligand (CD40), programmed death receptor-1 (PD-1), and IL-21, essential for B cell selection with maturation into ..
  4. HIV-driven B cell activation: role in the genesis of AIDS-related lymphoma
    Otoniel Martinez-Maza; Fiscal Year: 2013
    ..We also found that HIV virions carrying CD40 ligand (CD40L), a T cell-produced B cell stimulatory molecule, can drive B cell activation and AICDA expression...
  5. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..Laboratory measures include CD40 ligand, C-reactive protein, D-dimer, blood cell count and differential...
  6. T-cell Co-stimulation in Obesity-induced Inflammation and Atherosclerosis
    Vince N Montes; Fiscal Year: 2013
    ..The CD40-CD40L pathway can be inhibited by a neutralizing antibody to CD40 ligand (CD40L)...
  7. BBB Protection in HIV Infection: Barrier-shielding effects of PARP inhibition
    Yuri Persidsky; Fiscal Year: 2013
    ..We uncovered molecular mechanisms of BBB dysfunction [tight junction (TJ) phosphorylation, CD40/CD40 ligand interactions at BBB and signaling events behind the direct effects of HIV on brain endothelium]...
  8. Targeted Dendritic Cell Activation through Multi-Adjuvant Liposomes
    Gretchen Jimenez; Fiscal Year: 2013
    ..is a dual adjuvant system where VesiVax(R) lipid vesicles are formulated with a TLR9 agonist (CpG) and CD40 Ligand fused to the Company's proprietary Hydrophobic Domain (HD) technology...
  9. ANTIBODY V GENE EXPRESSION B CELL LYMPHOCYTIC LEUKEMIA
    Thomas J Kipps; Fiscal Year: 2013
    ..Further studies could enable us to refine this approach toward development of truly effective immune therapy for patients with this disease. ..
  10. Platelet activation by cocaine in HIV-1 patients involves IKK
    MICHELLE MEGAN KIEBALA; Fiscal Year: 2013
    ..HIV infection is associated with increased levels of molecules known to activate platelets, including soluble CD40 ligand (sCD40L), and platelet activating factor (PAF)...
  11. Mechanisms of CD40/CD40L in vascular injury and repair
    Guohong Li; Fiscal Year: 2013
    ..Abundant evidence indicates that the CD40-CD40 ligand (CD40L) pathway plays a pivotal role in immune and inflammatory responses...
  12. Phase I, Open-Label Dose-Escalation
    Januario E Castro; Fiscal Year: 2010
    ..activity of a new modality of immuno-gene therapy mediated by transduction of leukemia cells with CD154 (CD40 Ligand) using direct intra-lymph node (intranodal) injection of a replication-defective adenovirus vector that encodes ..
  13. Combination gene therapy for metastatic colon cancer
    Shu Hsia Chen; Fiscal Year: 2010
    ..We hypothesize that CD40 activation by agonistic antibody or Ig-CD40 ligand fusion protein can enhance anti-tumor responses through multiple mechanisms: 1) CD40 ligation can prevent Treg ..
  14. Generation and characterization of CD40L-modified Mice
    LORI RUTH COVEY; Fiscal Year: 2013
    ..Historically, there has been a widespread appreciation of the functional significance of interactions between CD40 ligand (CD40L, CD154) on activated CD4+ T cells and CD40 expressed on antigen presenting cells (APC) in both humoral ..
  15. Development of a multimeric CD40 ligand vaccine adjuvant
    RICHARD SYD KORNBLUTH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CD40 ligand (CD40L or CD154) is widely recognized as one of the most important endogenous activators of the immune system...
  16. Cognitive Function in Snoring Children
    David Gozal; Fiscal Year: 2013
    ..we will examine IL-6, TNF-1, and ApoE polymorphisms, as well as plasma levels of IL-6, TNF-1 , soluble CD40 ligand, and high sensitivity CRP, and adipokines such as leptin, adiponectin, resistin, visfatin, and ghrelin...
  17. PROLIFERATIVE CONDITIONING OF TUMOR-COMPETENT DENDRITIC CELL PRECURSORS
    Peter A Cohen; Fiscal Year: 2010
    ..IL-12p70 secretion;(3) it licenses spontaneous DC maturation, bypassing normal requirements for signals such as CD40 ligand or toll-like receptor (TLR) agonists;(4) it confers resistance to tumor-associated immunosuppressants such as ..
  18. Development of Immunotherapeutic Strategies in the Treatment of Lung Cancer
    Scott J Antonia; Fiscal Year: 2012
    ..The vaccines are (1) a dendritic cell-based vaccine using p53 as the tumor antigen, and (2) a GM-CSF and CD40 ligand-expressing bystander cell line admixed with tumor cells as the source of tumor antigens...
  19. Targeted Gene Therapy for Lymphoma
    Bruce F Smith; Fiscal Year: 2010
    ..We propose a novel approach to redirect a virus to target lymphoma using CD40 and CD40 ligand. This approach will be tested in spontaneous canine lymphoma, a rigorous model of the human disease...
  20. CD40 and TLR Agonists in Melanoma
    Jeffrey S Weber; Fiscal Year: 2010
    ..The CD40-CD40 ligand interaction is an essential element in the generation of T cell help which maintains potent, high-avidity and ..
  21. Chimeric SHIV VLP as an oral mucosal HIV vaccine
    QIZHI C YAO; Fiscal Year: 2013
    ..We have developed and characterized chimeric CD40 ligand/simian-human immunodeficiency (CD40L/SHIV) virus-like particles (VLPs) which possess the antigen presenting ..
  22. Mechanism of Radiation Mediated Clearance of HPV Positive Head and Neck Cancer
    WILLIAM CHARLES SPANOS; Fiscal Year: 2013
    ..Modalities include optimizing radiation dosing for clearance and determining whether CD40 ligand modulation of the immune system improves tumor clearance...
  23. HUMAN B CELL DIFFERENTIATION IN A MODEL SYSTEM
    LORI COVEY; Fiscal Year: 2009
    ..A critical molecule in this regard is the CD40 ligand (CD40L, CD154), which is expressed on activated T cells and through its interaction with CD40 on B cells, ..
  24. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2003
    ..Follow up will be done with MRI and EDSS at 18 and 24 months after enrollment(secondary outcome). The study will will allow us to achieve a power of 85 percent (32 percent reduction in plaque burden). ..
  25. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    ..Follow up will be done with MRI and EDSS at 18 and 24 months after enrollment(secondary outcome). The study will will allow us to achieve a power of 85 percent (32 percent reduction in plaque burden). ..
  26. Normal and Type-2 Diabetic Platelet Proteomics and Storage for Transfusion
    Richard Phipps; Fiscal Year: 2007
    ..regulators of inflammation, due to their release of potent proinflammatory and prothrombotic mediators such as CD40 ligand and thromboxane A2...
  27. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..We will also study the signaling pathways controlling gene expression of the CD40 ligand, CD154, that we believe is intimately involved with driving the signalosome pathway, to ascertain the mechanism ..
  28. A novel method to identify interacting partners of insoluble proteins
    F Nina Papavasiliou; Fiscal Year: 2010
    ..with defects in the signaling pathway that culminate in, amongst other things, AID production (such as CD40 and CD40 ligand defects)...
  29. Platelet Activation and Inflammatory Mediators
    Richard Phipps; Fiscal Year: 2007
    ..of platelets is that they contain and produce many immunomodulatory and proinflammatory mediators including CD40 ligand (CD40L), prostaglandins and cytokines. Platelets are not thought to possess transcription factors...
  30. ROLE OF CD40-CD40 LIGAND IN PRIMARY BILIARY CIRRHOSIS
    MARLYN MAYO; Fiscal Year: 2003
    ..that T cells orchestrate the immune attack on cholangiocytes via signaling to other cells in the liver through CD40 ligand. Specifically, expression of CD40 ligand by activated T cells in the liver stimulates B cells to increase ..
  31. MECHANISMS OF IMMUNITY TO VIRAL VACCINES IN INFANCY
    Hayley Gans; Fiscal Year: 2004
    ..The first goal will be to study the T-cell expression of CD40 ligand (CD40-L) in infants since this T-cell derived cytokine is necessary for providing B-cell help for antibody ..
  32. HTLV Deregulation of CD40(L) in Cancer&Neurodegeneration
    Edward Harhaj; Fiscal Year: 2007
    ..This proposal is centered on the deregulated expression of CD40 Ligand (CD40L) and its receptor CD40 in HTLV-l-infected T cells...
  33. Eptifibatide as Treatment for Acute Pain Episodes in Sickle Cell Disease
    Kenneth Ataga; Fiscal Year: 2009
    ..The potent inflammatory mediator, CD40 ligand (CD40L), is known to increase leukocyte proliferation, endothelial adhesiveness and procoagulant activity, once ..
  34. Immunotherapy of CLL with lentiviral expressed CD40-ligand
    Boro Dropulic; Fiscal Year: 2006
    ..This therapy will have significant relevance for leukemia and lymphoma patients, ultimately positively impacting public health in general. [unreadable] [unreadable] [unreadable]..
  35. INTERLEUKIN 12 AS IMMUNOTHERAPY IN LEISHMANIASIS
    FREDERICK HEINZEL; Fiscal Year: 2001
    ..CD40 is activated by antigen-specific T cells bearing the CD40 ligand and induces IL-12 necessary for Th1 CD4+ cellular responses and cure...
  36. Role of SOCS in Regulation of Transplantation Tolerance
    Stanislaw Stepkowski; Fiscal Year: 2004
    ..We have induced tolerance by promoting apoptosis by anti-CD40 Ligand antibody alone or in combination with CTLA4Ig or apoptosis-inducing agent, WP744...
  37. Enhancement of targeting HIV vaccine to dendritic cell
    Sang Moo Kang; Fiscal Year: 2004
    ..b>CD40 ligand (CD40L) was also demonstrated to bind to CD40 on DCs...
  38. OMEGA 3 LIPIDS AND CALORIES EFFECT ON SLE AND AGING
    Gabriel Fernandes; Fiscal Year: 2003
    ..We hypothesize that CR delays formation of Th-1/Th-2 subsets by co-stimulatory interaction including lowering CD40 ligand expression and by normalizing apoptosis in both lymphoid cells and target tissues...
  39. Associating genetic variation to resistance to severe malaria in East Africa
    David Reich; Fiscal Year: 2007
    ..We used this to establish evidence for selection at CD40 ligand and G6PD (two genes previously associated with malaria resistance)...
  40. Dendritic cell defects in cutaneous T-cell lymphoma
    Alain Rook; Fiscal Year: 2007
    ..DCs; 2) a marked depression in IL-12 and IFN-( production by patient DCs; 3) a marked abnormality of the CD40-CD40 ligand system; 4) correction of the defect in IL-12 production when patient cells are cultured with a novel ..
  41. HIV-1 DNA VACCINES THAT TARGET AND ACTIVATE CD40
    JEFFREY LEDBETTER; Fiscal Year: 2001
    ..We will construct DNA vaccines encoding CD40 ligand (CD154) or a single chain Fv (scFv) specific for CD40, fused with DNA encoding portions of the HIV-1 env ..
  42. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ..treatment of human dendritic cells (DC) derived from peripheral blood monocytes with CD40 ligand (CD4oL) will induce DC maturation, provide T-cell helper signals and augment the ability of DC to achieve ..
  43. DIFFERENTIATION AND FUNCTION OF HUMAN HELPER T CELLS
    SETH LEDERMAN; Fiscal Year: 2000
    ..Together, the proposed studies should advance our understanding of T cell helper function and its role in immunity and the maintenance of human health. ..
  44. TOLERANCE TO ISLET ALLOGRAFTS IN TYPE I DIABETES
    Bernhard Hering; Fiscal Year: 2005
    ..made include i) the demonstration of long-term islet allograft survival in non-human primates receiving anti-CD40 Ligand antibody monotherapy, ii) the induction of robust tolerance to murine islet allografts by allo-antigen ..
  45. Vector Mediated Vaccine Therapy of Cancer
    Wei Wei Zhang; Fiscal Year: 2004
    ..so that a fusion protein (TAA/ecdCD40L) consisting of a TAA linked to the extracellular domain (ecd) of the CD40 ligand (CD40L) is secreted from vector infected cells for 10 days in the vicinity of the vector injection site...
  46. ANTIRAT CD40L EFFECTS ON ISLET ALLOGRAFT SURVIVAL
    Karen Kover; Fiscal Year: 1999
    ..The objective of this proposal is to determine the effects of blocking the co-stimulatory molecule, CD40 ligand (using a novel antibody from Biogen, Inc...
  47. Using Genechips to Study the Immunological Roles of CD40
    Genhong Cheng; Fiscal Year: 2005
    ..CD40 is activated as a trimer after interaction with its partner, the CD40 ligand (CD40L), which is expressed on the surface of activated CD4+ helper T-cells...
  48. HUMAN B CELL DIFFERENTIATION IN A MODEL SYSTEM
    LORI COVEY; Fiscal Year: 1999
    ..activation of the RAMOS B cells could be measured by up-regulation of surface CD23 and was dependent on the CD40 ligand (CD40-L) expressed on the surface of the D1.1 T cells...
  49. MECHANISMS OF IMMUNOSENESCENCE
    Garnett Kelsoe; Fiscal Year: 1999
    ..These studies will also focus on the role of complement in the GC reaction and effective humoral immunity to shed light on new strategies for enhancing the quantity and quality of serum antibody responses. ..
  50. REDUCED CYTOKINE PRODUCTION BY NEONATAL T CELLS
    David Lewis; Fiscal Year: 2000
    ....
  51. Combination Immunotherapy for Lung Cancer
    Scott Antonia; Fiscal Year: 2007
    ..extended the concept of using GM-CSF by adding the expression of a potent activator of dendritic cells (DCs), CD40 ligand, in a murine model and showed that the combination was more effective than GM-CSF alone...
  52. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
    ..abstract_text> ..
  53. Transfer of the CD40 ligand gene to esophageal carcinoma
    Robert Korst; Fiscal Year: 2007
    ..will evaluate the concept that transient modification of the genetic repertoire of esophageal tumors to express CD40 Ligand (CD40L; a potent activator of DC) will induce the accumulation of activated DC within the tumor, and the in ..
  54. AKNA, germinal center reaction and immunity.
    Hector Martinez Valdez; Fiscal Year: 2007
    ..requires cognate receptor/ligand interactions, among which, the ligation of B cetl- CD40 by the T celI-CD40 ligand (CD154) provides the essential stimuli for cell proliferation, survival, and induction of B cell memory...
  55. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2006
    ..Unexpectedly, CD4 T-cell clones expanded in vivo lose the expression of the costimulatory molecules, CD28 and CD40 ligand, and acquire the expression of killer-cell immunoglobulin-like receptors (KIR)...
  56. Regulation of Th1 responses by IL-2 receptor blockade
    John McDyer; Fiscal Year: 2007
    ..We hypothesize CD40 ligand (CD40L)/CD40 interactions play a major role in HAT-mediated inhibition of IL-12- dependent Thl responses and ..
  57. CONTROL OF SWITCH RECOMBINATION BY CD40 LIGAND
    MICHAEL BERTON; Fiscal Year: 2000
    ..T-cell contact-dependent signals required for isotype switching are provided by the CD40 ligand (CD40L)-CD40 interaction, but nothing is known about how these signals regulate isotype switching...
  58. Platelet-Derived TNF-Family Protein Expression
    Scott Crist; Fiscal Year: 2006
    The TNF family proteins CD154 (CD40 Ligand), CD178 (Fas Ligand), and TNF related apoptosis inducing ligand (TRAIL) are known to play important roles in the modulation of inflammation and adaptive immune responses...
  59. ALLERGEN GENE VACCINATION IN MOUSE MODEL OF FOOD ALLERGY
    Anthony Horner; Fiscal Year: 2001
    ..Horner trained in allergy and immunology at Boston Children's Hospital from 1991 - 1994, where he studied the CD40 ligand (CD40L) under Dr. Raif Geha. He came to UCSD in 1994 and until recently continued to work on CD40L. Drs...
  60. Role of soluble CD40L as a predictor of HIV CNS impairment
    JOAN BERMAN; Fiscal Year: 2009
    ..A key axis in the immune system, the interactions between CD40-CD40 ligand (CD40L) is essential for immune cell activation...
  61. Blocking airway inflammation with B7-DC cross-linking Ab
    Larry Pease; Fiscal Year: 2009
    ..Understanding the mechanisms governing modulation of pathologic lung inflammation with this human antibody will provide the basis for future studies in human patients. ..
  62. IRS2 AND B CELL HOMEOSTASIS
    Achsah Keegan; Fiscal Year: 2000
    ..is provided for IL -4 induced tyrosine phosphorylation of IRS -2 in small resting B- cells and in LPS or CD40 ligand stimulated blasts...
  63. MOLECULAR MECHANISMS OF THE IGE ALLERGIC RESPONSE
    Raif Geha; Fiscal Year: 2007
    ..The cytokines IL-4 and 11-13 plays a critical role in the development of Th2 helper cells and synergizes with CD40 ligand (CD40L) to induce IgE isotype switching...
  64. GENETIC ENGINEERING OF VASCULAR TISSUE
    David Dichek; Fiscal Year: 2002
    ..by the adjunctive use of targeted immunosuppression to block immune cell activation that occurs via B7 and/or CD40 ligand signaling...
  65. VEGF And Renal Inflammation
    Soumitro Pal; Fiscal Year: 2007
    ..We have identified a mechanistic link between immune response (involving CD40 ligand, expressed on activated T cells and platelets, and CD40 interactions) and the overexpression of VEGF...