antiporters

Summary

Summary: Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.

Top Publications

  1. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
  2. pmc Phylogenetic relationships within cation transporter families of Arabidopsis
    P Maser
    Division of Biology, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 126:1646-67. 2001
  3. pmc A genomewide association study of skin pigmentation in a South Asian population
    Renee P Stokowski
    Perlegen Sciences, Mountain View, CA 94043, USA
    Am J Hum Genet 81:1119-32. 2007
  4. pmc Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle
    Liang Feng
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Science 330:635-41. 2010
  5. ncbi Genetic evidence for the convergent evolution of light skin in Europeans and East Asians
    Heather L Norton
    Department of Anthropology, The Pennsylvania State University, PA, USA
    Mol Biol Evol 24:710-22. 2007
  6. pmc Expression of arabidopsis CAX2 in tobacco. Altered metal accumulation and increased manganese tolerance
    K D Hirschi
    Baylor College of Medicine, Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas 77030, USA
    Plant Physiol 124:125-33. 2000
  7. pmc Fluoride resistance and transport by riboswitch-controlled CLC antiporters
    Randy B Stockbridge
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 109:15289-94. 2012
  8. ncbi Vacuolar Ca(2+) uptake
    Jon K Pittman
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Cell Calcium 50:139-46. 2011
  9. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
  10. ncbi SLC4A11 mutations in Fuchs endothelial corneal dystrophy
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore
    Hum Mol Genet 17:656-66. 2008

Research Grants

  1. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
  2. pH Regulation in Bacillus subtilis (AREA R15)
    JOAN SLONCZEWSKI; Fiscal Year: 2009
  3. The plant-like vacuole of Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2013
  4. Ca2+ Transport Mechanism of CaCA Protein Family
    Lei Zheng; Fiscal Year: 2013
  5. Proton-Coupling Strategies in Alkaliphilic Bacillus
    Terry Ann Krulwich; Fiscal Year: 2013
  6. Simulation of Proton Translocation in Biomolecules
    Gregory A Voth; Fiscal Year: 2013
  7. Targeting System Xc- for the Treatment of Addiction
    John R Mantsch; Fiscal Year: 2010
  8. Structure and Function of Neurotransmitter Transporters
    James E Gouaux; Fiscal Year: 2013
  9. Structural Dynamics of Drug/Proton Antiport by a Multidrug Efflux Pump
    PHILLIP RYAN STEED; Fiscal Year: 2013
  10. Structural Analysis of Multidrug Transport
    Mark E Girvin; Fiscal Year: 2013

Detail Information

Publications296 found, 100 shown here

  1. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  2. pmc Phylogenetic relationships within cation transporter families of Arabidopsis
    P Maser
    Division of Biology, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 126:1646-67. 2001
    ..achieved for individual members, including potassium transporters and channels, sodium transporters, calcium antiporters, cyclic nucleotide-gated channels, cation diffusion facilitator proteins, natural resistance-associated ..
  3. pmc A genomewide association study of skin pigmentation in a South Asian population
    Renee P Stokowski
    Perlegen Sciences, Mountain View, CA 94043, USA
    Am J Hum Genet 81:1119-32. 2007
    ..Our study is the first to interrogate polymorphisms across the genome, to find genetic determinants of the natural variation of skin pigmentation within a human population...
  4. pmc Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle
    Liang Feng
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Science 330:635-41. 2010
    ..Comparison with prokaryotic CLC shows that a gating glutamate residue changes conformation and suggests a basis for 2:1 Cl(-)/H(+) exchange and a simple mechanistic connection between CLC channels and transporters...
  5. ncbi Genetic evidence for the convergent evolution of light skin in Europeans and East Asians
    Heather L Norton
    Department of Anthropology, The Pennsylvania State University, PA, USA
    Mol Biol Evol 24:710-22. 2007
    ..These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians...
  6. pmc Expression of arabidopsis CAX2 in tobacco. Altered metal accumulation and increased manganese tolerance
    K D Hirschi
    Baylor College of Medicine, Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas 77030, USA
    Plant Physiol 124:125-33. 2000
    ..These results suggest that CAX2 has a broad substrate range and modulation of this transporter may be an important component of future strategies to improve plant ion tolerance...
  7. pmc Fluoride resistance and transport by riboswitch-controlled CLC antiporters
    Randy B Stockbridge
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 109:15289-94. 2012
    ..channels and transporters, CLC(F)s bear a channel-like valine rather than a transporter-like glutamate, and yet are F(-)/H(+) antiporters. Finally, F(-)/H(+) exchange occurs with 1:1 stoichiometry, in contrast to the usual value of 2:1.
  8. ncbi Vacuolar Ca(2+) uptake
    Jon K Pittman
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Cell Calcium 50:139-46. 2011
    ..Studies suggest that Ca(2+) uptake into vacuoles and other related acidic Ca(2+) stores occurs by conserved mechanisms which developed early in evolution...
  9. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
    ..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R...
  10. ncbi SLC4A11 mutations in Fuchs endothelial corneal dystrophy
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore
    Hum Mol Genet 17:656-66. 2008
    ....
  11. pmc Characterization of CAX4, an Arabidopsis H(+)/cation antiporter
    Ning Hui Cheng
    Baylor College of Medicine, Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA
    Plant Physiol 128:1245-54. 2002
    ..These findings suggest that CAX transporters may modulate their ion transport properties through alterations at the N terminus...
  12. pmc Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels
    Alessio Accardi
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    J Gen Physiol 123:109-19. 2004
    ..These effects correlate well with known characteristics of eukaryotic CLC channels. The E148A mutant displays nearly ideal Cl- selectivity...
  13. ncbi SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis
    Rebecca S Ginger
    Unilever Corporate Research, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, England, United Kingdom
    J Biol Chem 283:5486-95. 2008
    ..We suggest that NCKX5 directly regulates human epidermal melanogenesis and natural skin color through its intracellular potassium-dependent exchanger activity...
  14. pmc Missense mutations in the sodium borate cotransporter SLC4A11 cause late-onset Fuchs corneal dystrophy
    S Amer Riazuddin
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Hum Mutat 31:1261-8. 2010
    ..Taken together with a recent model between FCD and yet another early onset corneal dystrophy, PPCD, our data suggest a shared pathomechanism and genetic overlap across several corneal dystrophies...
  15. pmc The Arabidopsis cax1 mutant exhibits impaired ion homeostasis, development, and hormonal responses and reveals interplay among vacuolar transporters
    Ning Hui Cheng
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Plant Cell 15:347-64. 2003
    ..36% increase in tonoplast Ca(2+)-ATPase activity, and increased expression of the putative vacuolar Ca(2+)/H(+) antiporters CAX3 and CAX4. Enhanced growth was displayed by the cax1 lines under Mn(2+) and Mg(2+) stress conditions...
  16. pmc Expression patterns of a novel AtCHX gene family highlight potential roles in osmotic adjustment and K+ homeostasis in pollen development
    Heven Sze
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742 5815, USA
    Plant Physiol 136:2532-47. 2004
    ..japonica, suggesting diversification of CHX in Arabidopsis. These results reveal a novel CHX gene family in flowering plants with potential functions in pollen development, germination, and tube growth...
  17. ncbi The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs
    I T Paulsen
    School of Biological Sciences, University of Sydney, Australia
    Mol Microbiol 19:1167-75. 1996
    ..The roles of specific residues, a possible mechanistic model of drug efflux, and the primary physiological role(s) of the SMR proteins are discussed...
  18. ncbi Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Renal Physiol 280:F356-64. 2001
    ..The conclusion is that pendrin is an apical Cl-/base exchanger in the kidney proximal tubule and CCD and mediates Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange...
  19. pmc Structure of a slow CLC Cl⁻/H+ antiporter from a cyanobacterium
    Hariharan Jayaram
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, United States
    Biochemistry 50:788-94. 2011
    ..SY thus shares a similar structure and a common transport mechanism to EC, but it is by comparison slow, a result that refutes the idea that the transport mechanism of CLCs leads to intrinsically high rates...
  20. pmc Ins and outs of major facilitator superfamily antiporters
    Christopher J Law
    The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Microbiol 62:289-305. 2008
    ..Recent work shows that MFS antiporters, and perhaps all members of the MFS, share the same three-dimensional structure, consisting of two domains that ..
  21. pmc Comparative study of the active cadmium efflux systems operating at the plasma membrane and tonoplast of cucumber root cells
    Magdalena Migocka
    Wroclaw University, Institute of Plant Biology, Department of Plant Physiology, Kanonia 6 8, 50 328 Wroclaw, Poland
    J Exp Bot 62:4903-16. 2011
    ....
  22. pmc Skin color variation in Orang Asli tribes of Peninsular Malaysia
    Khai C Ang
    Department of Experimental Pathology and Jake Gittlen Cancer Research Foundation, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 7:e42752. 2012
    ..These results suggest that the Senoi are suitable for mapping East Asian skin color genes...
  23. ncbi The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters
    Troels Wabakken
    Department of Immunology, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway
    Biochem Biophys Res Commun 306:718-24. 2003
    ..We have also identified 10 SLC41A1 homologs in Homo sapiens, Mus musculus, Drosophila melanogaster, Anopheles gambiae, and Caenorhabditis elegans, and propose that these hypothetical proteins belong to a novel eukaryotic gene family...
  24. ncbi Residues in internal repeats of the rice cation/H+ exchanger are involved in the transport and selection of cations
    Takehiro Kamiya
    Laboratory of Cell Dynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 279:812-9. 2004
    ..Furthermore, several residues in repeats c-1 and c-2 were found to be conserved in animal Na+/Ca2+ exchangers. Finally, we suggest that these re-entrant repeats may form a vestibule or filter for cation selection...
  25. ncbi DNA-based eye colour prediction across Europe with the IrisPlex system
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:330-40. 2012
    ....
  26. pmc Gating of CFTR by the STAS domain of SLC26 transporters
    Shigeru B H Ko
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    Nat Cell Biol 6:343-50. 2004
    ..These findings provide a new understanding of epithelial chloride and bicarbonate transport and may have important implications for both cystic fibrosis and diseases associated with SLC26T...
  27. pmc Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome
    Dawei Jiang
    Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2249-54. 2013
    ..We conclude that loss of Letm1 contributes to the pathology of Wolf-Hirschhorn syndrome in humans and may contribute to seizure phenotypes by reducing glucose oxidation and other specific metabolic alterations...
  28. ncbi Regulatory mechanism underlying cyclic changes in mouse uterine bicarbonate secretion: role of estrogen
    Qiong He
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Reproduction 140:903-10. 2010
    ....
  29. ncbi Root development under metal stress in Arabidopsis thaliana requires the H+/cation antiporter CAX4
    Hui Mei
    Vegetable and Fruit Improvement Center, Texas A and M University, College Station, TX 77845, USA
    New Phytol 183:95-105. 2009
    ..The DR5::GUS auxin reporter detected reduces auxin responses in the cax4 lines. * These results indicate that CAX4 is a cation/H(+) antiporter that plays an important function in root growth under heavy metal stress conditions...
  30. ncbi Control of membrane protein topology by a single C-terminal residue
    Susanna Seppälä
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE 106 91 Stockholm, Sweden
    Science 328:1698-700. 2010
    ..This observation points to an unanticipated plasticity in membrane protein insertion mechanisms...
  31. pmc The role of CAX1 and CAX3 in elemental distribution and abundance in Arabidopsis seed
    Tracy Punshon
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Plant Physiol 158:352-62. 2012
    ..This work highlights a powerful technology for inferring transport function and quantifying nutrient changes...
  32. ncbi Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci
    Anthony L Cook
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Queensland, Australia
    J Invest Dermatol 129:392-405. 2009
    ....
  33. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  34. ncbi Identification of three distinct phylogenetic groups of CAX cation/proton antiporters
    T Shigaki
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Room 9016, CNRC, 1100 Bates Street, Houston, TX 77030, USA
    J Mol Evol 63:815-25. 2006
    ..For the first time, these results clearly define the CAX exchanger family and its subtypes in phylogenetic terms. The surprising diversity of CAXs demonstrates their potential range of biochemical properties and physiologic relevance...
  35. ncbi Structure and mechanism of a metal-sensing regulatory RNA
    Charles E Dann
    Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 130:878-92. 2007
    ..Given the distribution of this RNA element, it may constitute a common mode for bacterial metal ion regulation, and its discovery suggests the possibility of additional RNA-based metal sensors in modern and primordial organisms...
  36. ncbi The cation/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications
    Xinjiang Cai
    The Cardiovascular Research Group, Departments of Biochemistry and Molecular Biology and Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Mol Biol Evol 21:1692-703. 2004
    ..These findings will provide guides for future studies concerning structures, functions, and evolutionary origins of the cation/Ca(2+) exchangers...
  37. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  38. pmc Participation of endomembrane cation/H+ exchanger AtCHX20 in osmoregulation of guard cells
    Senthilkumar Padmanaban
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742 5815, USA
    Plant Physiol 144:82-93. 2007
    ..function of CHX20, cDNA was expressed in a yeast (Saccharomyces cerevisiae) mutant that lacks Na+(K+)/H+ antiporters (Deltanhx1 Deltanha1 Deltakha1) and plasma membrane Na+ pumps (Deltaena1-4)...
  39. ncbi A widespread transposable element masks expression of a yeast copper transport gene
    S A Knight
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606, USA
    Genes Dev 10:1917-29. 1996
    ..These results underscore the importance of mobile DNA elements in the alteration of gene function and phenotypic variation...
  40. pmc CLC channels and transporters: proteins with borderline personalities
    Alessio Accardi
    Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochim Biophys Acta 1798:1457-64. 2010
    ..This review focuses on the recent mechanistic insights on the how the structural similarities between CLC channels and transporters translate in unexpected mechanistic analogies between these two sub-classes...
  41. ncbi Enhanced Cd2+ -selective root-tonoplast-transport in tobaccos expressing Arabidopsis cation exchangers
    V Koren'kov
    Department of Plant and Soil Sciences, Plant Biology Program, University of Kentucky, Lexington, KY 40546, USA
    Planta 225:403-11. 2007
    ..Results support a model in which certain CAX antiporters are somewhat more selective for particular divalent cations.
  42. ncbi SLC4 base (HCO3 -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models
    Alexander Pushkin
    Division of Nephrology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Rm 7 155 Factor Bldg, Los Angeles, CA 90095, USA
    Am J Physiol Renal Physiol 290:F580-99. 2006
    ..This review focuses on recent advances in our understanding of the molecular organization and functional properties of SLC4 transporters and their role in disease...
  43. ncbi Mutations in CAX1 produce phenotypes characteristic of plants tolerant to serpentine soils
    H D Bradshaw
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    New Phytol 167:81-8. 2005
    ....
  44. pmc Cell-specific vacuolar calcium storage mediated by CAX1 regulates apoplastic calcium concentration, gas exchange, and plant productivity in Arabidopsis
    Simon J Conn
    School of Agriculture, Food, and Wine, University of Adelaide, Glen Osmond, South Australia 5064, Australia
    Plant Cell 23:240-57. 2011
    ..We establish CAX1 as a key regulator of apoplastic [Ca(2+)] through compartmentation into mesophyll vacuoles, a mechanism essential for optimal plant function and productivity...
  45. ncbi Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities
    T Igarashi
    Nat Genet 23:264-6. 1999
  46. pmc NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli
    Y Morita
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Antimicrob Agents Chemother 42:1778-82. 1998
    ..Thus, it seems that NorM and YdhE differ somehow in substrate specificity...
  47. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  48. ncbi Crystal structure of the MgtE Mg2+ transporter
    Motoyuki Hattori
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama shi, Kanagawa 226 8501, Japan
    Nature 448:1072-5. 2007
    ..Whether this presumed regulation controls gating of an ion channel or opening of a secondary active transporter remains to be determined...
  49. pmc Expression of Arabidopsis CAX1 in tobacco: altered calcium homeostasis and increased stress sensitivity
    K D Hirschi
    Baylor College of Medicine, Department of Pediatrics, U S Department of Agriculture, Agricultural Research Service, Children s Nutrition Research Center, Houston, Texas 77030, USA
    Plant Cell 11:2113-22. 1999
    ..These results emphasize that regulated expression of Ca(2+)/H(+) antiport activity is critical for normal growth and adaptation to certain stresses...
  50. pmc Borate transporter SLC4A11 mutations cause both Harboyan syndrome and non-syndromic corneal endothelial dystrophy
    Julie Desir
    Laboratory for Medical Genetics, ULB, Brussels, Belgium
    J Med Genet 44:322-6. 2007
    ..Why some mutations cause hearing loss in addition to corneal dystrophy is presently unclear. These findings extend the implication of the SLC4A11 borate transporter beyond corneal dystrophy to perceptive deafness...
  51. pmc Arginine-agmatine antiporter in extreme acid resistance in Escherichia coli
    Ram Iyer
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
    J Bacteriol 185:6556-61. 2003
    ..Evidence for a lysine-dependent XAR system in E. coli is also presented. The protection by lysine, however, is milder than that by arginine...
  52. ncbi Expression profile of the genes for rice cation/H+ exchanger family and functional analysis in yeast
    Takehiro Kamiya
    Laboratory of Cell Dynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Furocho, Chikusa ku, Japan
    Plant Cell Physiol 46:1735-40. 2005
    ..All exchangers, except for OsCAX2, conferred tolerance to calcium. OsCAX1a and OsCAX3 conferred tolerance to manganese. The diversity of expression sites and substrates suggest the broad range function of CAX...
  53. pmc Congenital hereditary endothelial dystrophy - mutation analysis of SLC4A11 and genotype-phenotype correlation in a North Indian patient cohort
    Preeti Paliwal
    Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
    Mol Vis 16:2955-63. 2010
    ....
  54. pmc Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold
    Moritz Hentschke
    Department of Human Genetics, UKE Hamburg, Butenfeld 42, 22529 Hamburg, Germany
    Mol Cell Biol 26:182-91. 2006
    ..These findings strongly support the hypothesis that AE3 modulates seizure susceptibility and, therefore, are of significance for understanding the role of intracellular pH in epilepsy...
  55. ncbi Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM
    Scarlett R Holdsworth
    School of Biological Sciences, Medical Biology Centre, Queen s University Belfast, Belfast BT9 7BL, UK
    Biochimie 94:1334-46. 2012
    ..This work provides a firm foundation for structural studies on this class of multidrug transporter protein...
  56. ncbi Expression of AtMHX, an Arabidopsis vacuolar metal transporter, is repressed by the 5' untranslated region of its gene
    O David-Assael
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Exp Bot 56:1039-47. 2005
    ..These data suggest that AtMHX expression is repressed by the 5' UTR of its gene...
  57. ncbi NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation
    Meeyoung Park
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Cell 16:331-41. 2004
    ..These findings may reveal a previously unrecognized role for NaBC1 in borate homeostasis and open the way to better understanding of the many presumed physiological roles of borate in animals...
  58. ncbi Oligomeric structure of the carnitine transporter CaiT from Escherichia coli
    Kutti Ragunath Vinothkumar
    Max Planck Institute of Biophysics, Max von Laue Strasse 3, D 60438 Frankfurt am Main, Germany
    J Biol Chem 281:4795-801. 2006
    ..The implications of the trimeric structure on the function of CaiT are discussed...
  59. ncbi Manganese specificity determinants in the Arabidopsis metal/H+ antiporter CAX2
    Toshiro Shigaki
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:6610-7. 2003
    In plants and fungi, vacuolar transporters help remove potentially toxic cations from the cytosol. Metal/H(+) antiporters are involved in metal sequestration into the vacuole...
  60. ncbi OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans
    Ellen E Quillen
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Hum Genet 131:1073-80. 2012
    ..In addition to SLC24A5 and SLC45A2, genes previously associated with European/non-European differences in skin pigmentation, OPRM1 and EGFR were associated with variation in skin pigmentation in New World populations for the first time...
  61. ncbi Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study
    Terry A Krulwich
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Microbiol 3:566-72. 2005
    ..The recent observations that Tet(L), a tetracycline-efflux transporter, and MdfA, a multidrug-efflux transporter, both confer alkali tolerance offer a striking case study in support of this hypothesis...
  62. pmc Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters
    Liang Feng
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:11699-704. 2012
    ....
  63. ncbi The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds
    Scarlett R Holdsworth
    School of Biological Sciences, Medical Biology Centre, Queen s University Belfast, Belfast BT9 7BL, UK
    J Antimicrob Chemother 68:831-9. 2013
    ....
  64. pmc Progesterone downregulates oestrogen-induced expression of CFTR and SLC26A6 proteins and mRNA in rats' uteri
    K Gholami
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Biomed Biotechnol 2012:596084. 2012
    ..Under progesterone (P) dominance, fluid loss assists uterine closure which is associated with pH reduction. We hypothesize that P inhibits uterine fluid secretion and HCO3⁻ transport...
  65. ncbi A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes
    B Ortmann
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA
    Science 277:1306-9. 1997
    ..Tapasin expression also corrected the defective recognition of virus-infected 220 cells by class I-restricted cytotoxic T cells, establishing a critical functional role for tapasin in MHC class I-restricted antigen processing...
  66. ncbi Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney
    M D Parker
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
    Biochem Biophys Res Commun 282:1103-9. 2001
    ..Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl(-)/HCO(-)(3) exchanger located on the apical membrane of beta-intercalated kidney cells...
  67. pmc Genetic analysis of two Indian families affected with congenital hereditary endothelial dystrophy: two novel mutations in SLC4A11
    Arun Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Mol Vis 13:39-46. 2007
    ..The purpose of this study was to carry out genetic analysis of CHED2 in two Indian families...
  68. ncbi Calcium uptake mechanisms of mitochondria
    Jaime Santo-Domingo
    Department of Cell Physiology and Metabolism, University of Geneva, 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Biochim Biophys Acta 1797:907-12. 2010
    ..In this article, we will review the properties of the Ca2+ import systems of mitochondria and discuss how Ca2+ uptake via an electrogenic 1:1 Ca2+/H+ antiport challenges our current thinking of the mitochondrial Ca2+ uptake mechanism...
  69. pmc Predicting phenotype from genotype: normal pigmentation
    Robert K Valenzuela
    Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    J Forensic Sci 55:315-22. 2010
    ..Thus, these models may be of predictive value to determine an individual's pigmentation type from a forensic sample, independent of ethnic origin...
  70. pmc In-vivo functional study on the involvement of CFTR, SLC26A6, NHE-1 and CA isoenzymes II and XII in uterine fluid pH, volume and electrolyte regulation in rats under different sex-steroid influence
    Khadijeh Gholami
    Dept of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Med Sci 10:1121-34. 2013
    ....
  71. pmc Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice
    Paul A Dawson
    School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    J Clin Invest 120:706-12. 2010
    ..These data suggest that Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity...
  72. pmc Intracellular proton-transfer mutants in a CLC Cl-/H+ exchanger
    Hyun Ho Lim
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    J Gen Physiol 133:131-8. 2009
    ..The results support the idea that Glu(in) is the internal proton-transfer residue that delivers protons from intracellular solution to the protein interior, where they couple to Cl(-) movements to bring about Cl(-)/H(+) exchange...
  73. ncbi A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome
    Angus G McQuibban
    Department of Biochemistry, University of Toronto, Canada M5S 1A8
    Hum Mol Genet 19:987-1000. 2010
    ..Taken together our results demonstrate the function of DmLETM1 as a mitochondrial osmoregulator through its KHE activity and uncover a pathophysiological WHS phenotype in the model organism D. melanogaster...
  74. ncbi A cation-regulated and proton gradient-dependent cation transporter from Chlamydomonas reinhardtii has a role in calcium and sodium homeostasis
    Jon K Pittman
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    J Biol Chem 284:525-33. 2009
    ....
  75. ncbi Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p
    Jon K Pittman
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Microbiol 54:1104-16. 2004
    ..Additionally, we demonstrate that mutation of L208P alone is enough to confer calcineurin-dependent Mn(2+) tolerance. This study demonstrates that calcineurin can positively regulate the transport of cations by VCX1-M1p...
  76. ncbi Prediction of eye color from genetic data using Bayesian approach
    Ewelina Pośpiech
    Section of Forensic Genetics, Institute of Forensic Research, Krakow, Poland
    J Forensic Sci 57:880-6. 2012
    ....
  77. pmc SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia
    Carol A Bertrand
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Gen Physiol 133:421-38. 2009
    ....
  78. ncbi The BCCT family of carriers: from physiology to crystal structure
    Christine Ziegler
    Max Planck Institute for Biophysics, Max von Laue Street 3, D 60438 Frankfurt, Germany
    Mol Microbiol 78:13-34. 2010
    ..determinants governing the high-affinity binding of the compatible solutes by BetP and CaiT, the coupling in symporters and antiporters, and the osmoregulatory properties are discussed in detail for BetP and various BCCT carriers.
  79. pmc Lipid bilayer composition influences small multidrug transporters
    Kalypso Charalambous
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    BMC Biochem 9:31. 2008
    ..Lipid bilayer lateral pressures affect membrane protein insertion, folding and activity and have been shown to influence reconstitution, topology and activity of membrane transport proteins...
  80. pmc Slc26a9--anion exchanger, channel and Na+ transporter
    Min Hwang Chang
    Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Membr Biol 228:125-40. 2009
    ..Thus, the Slc26a9 transporter channel is uniquely suited for dynamic and tissue-specific physiology or regulation in epithelial tissues...
  81. ncbi Characterization of Arabidopsis Ca2+/H+ exchanger CAX3
    Murli Manohar
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, Texas 77030, United States
    Biochemistry 50:6189-95. 2011
    ..These studies demonstrate shared and unique aspects of CAX1 and CAX3 transport and regulation...
  82. ncbi The Arabidopsis cax3 mutants display altered salt tolerance, pH sensitivity and reduced plasma membrane H+-ATPase activity
    Jian Zhao
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA
    Planta 227:659-69. 2008
    ..These findings catalog an array of CAX phenotypes and assign a specific role for CAX3 in response to salt tolerance...
  83. pmc Investigation of ligand binding to the multidrug resistance protein EmrE by isothermal titration calorimetry
    Curtis W Sikora
    Division of Biochemistry, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
    Biophys J 88:475-82. 2005
    ..Thermodynamic properties demonstrated this interaction to be enthalpy-driven with similar enthalpies of 8-12 kcal/mol for each of the drugs in any of the membrane mimetics...
  84. pmc Protonation of glutamate 208 induces the release of agmatine in an outward-facing conformation of an arginine/agmatine antiporter
    Elia Zomot
    Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:19693-701. 2011
    ....
  85. ncbi High expression in leaves of the zinc hyperaccumulator Arabidopsis halleri of AhMHX, a homolog of an Arabidopsis thaliana vacuolar metal/proton exchanger
    Benayahu Elbaz
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Plant Cell Environ 29:1179-90. 2006
    ..halleri. Metal sequestration into root vacuoles was suggested to inhibit hyperaccumulation in the shoot. Our data implicate AhMHX as a candidate gene in metal accumulation or tolerance in A. halleri...
  86. pmc Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transporters
    Iris Nasie
    Department of Biological Chemistry, Alexander A Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    J Biol Chem 285:15234-44. 2010
    ..The results suggest that the small multidrug transporters are at an evolutionary junction and provide a model for the evolution of structure of transport proteins...
  87. ncbi Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2
    Mikiko Soejima
    Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, 830 0011, Japan
    Int J Legal Med 121:36-9. 2007
    ..Our data confirm the earlier results and furthermore demonstrate that the SLC45A2 allele is a more specific AIM than the SLC24A5 allele because the former clearly distinguishes the Sri Lankans from the Europeans...
  88. ncbi PfCHA is a mitochondrial divalent cation/H+ antiporter in Plasmodium falciparum
    Alexander Rotmann
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Mol Microbiol 76:1591-606. 2010
    ....
  89. pmc Vacuolar Ca2+/H+ transport activity is required for systemic phosphate homeostasis involving shoot-to-root signaling in Arabidopsis
    Tzu Yin Liu
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
    Plant Physiol 156:1176-89. 2011
    ..Based on these findings, we propose that CAX1 and CAX3 mediate a shoot-derived signal that modulates the activity of the root P(i) transporter system, likely in part via posttranslational regulation of PHT1;1 P(i) transporters...
  90. ncbi Functions of tetracycline efflux proteins that do not involve tetracycline
    T A Krulwich
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York 10029, USA
    J Mol Microbiol Biotechnol 3:237-46. 2001
    ..It will also be of interest to investigate the implications of Tet(L) and Tet(K) multifunctionality on the emergence and persistence of these antibiotic-resistance genes...
  91. pmc The Pseudomonas aeruginosa magnesium transporter MgtE inhibits transcription of the type III secretion system
    Gregory G Anderson
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan St, SL 320, Indianapolis, IN 46202, USA
    Infect Immun 78:1239-49. 2010
    ..Thus, the magnesium transport function of MgtE does not fully explain the regulatory effects of MgtE on cytotoxicity. Overall, our results indicate that MgtE modulates expression of T3SS genes...
  92. pmc Physiological role of the chaA gene in sodium and calcium circulations at a high pH in Escherichia coli
    T Ohyama
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Bacteriol 176:4311-5. 1994
    ..5, but the activity at neutral pH was not reduced by the deletion of chaA. Therefore, it was also suggested that ChaA plays a role in calcium ion circulation at alkaline pH...
  93. ncbi The expression of the open reading frame of Arabidopsis CAX1, but not its cDNA, confers metal tolerance in yeast
    T Shigaki
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
    Plant Biol (Stuttg) 12:935-9. 2010
    ..Expression studies demonstrated that expressing the CAX1 ORF in yeast elevates CAX1 RNA and protein levels. Our results suggest that the 3′-UTR modulates expression of CAX1 in yeast...
  94. pmc Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease
    Jesus M Banales
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Pathol 173:1637-46. 2008
    ..Therapeutic interventions that block the activation of these proteins might inhibit cyst expansion in polycystic liver disease...
  95. ncbi Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3
    Jian Zhao
    United States Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030 23600, USA
    J Biol Chem 284:4605-15. 2009
    ..In vivo interaction between the CAX proteins was shown using a split ubiquitin yeast two-hybrid system and gel shift assays. These findings demonstrate cation exchange plasticity through hetero-CAX interactions...
  96. ncbi Genotype/phenotype correlation in glycogen storage disease type 1b: a multicentre study and review of the literature
    Daniela Melis
    Dipartimento di Pediatria, Universita Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
    Eur J Pediatr 164:501-8. 2005
    ..In three patients no mutations were detected...
  97. ncbi A model for coupling of H(+) and substrate fluxes based on "time-sharing" of a common binding site
    H Yerushalmi
    Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Biochemistry 39:14711-9. 2000
    ..The occupancy of this site by H(+) and substrate is mutually exclusive and provides the basis of the simplest coupling for two fluxes...
  98. ncbi Exchangers NCKX2, NCKX3, and NCKX4: identification of Thr-551 as a key residue in defining the apparent K(+) affinity of NCKX2
    Frank Visser
    Libin Cardiovascular Institute of Alberta and the Hotchkiss Brain Institute, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 282:4453-62. 2007
    ..The results of this study provide important information about the structure and function of NCKX proteins and will be critical to understanding their roles in neuronal Ca(2+) signaling...
  99. pmc Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae
    Olivier Cagnac
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Apartado 419, E 18080 Granada, Spain
    J Biol Chem 285:33914-22. 2010
    ..The relative importance of Nhx1p, Vnx1p, and Vcx1p in the vacuolar accumulation of monovalent cations will be discussed...
  100. ncbi Identification, expression, and functional analyses of a thylakoid ATP/ADP carrier from Arabidopsis
    Sophie Thuswaldner
    Division of Cell Biology, Linkoping University, SE 581 85 Linkoping, Sweden
    J Biol Chem 282:8848-59. 2007
    ..Its expression is highest in developing green tissues and in leaves undergoing senescence or abiotic stress. We propose that the TAAC protein supplies ATP for energy-dependent reactions during thylakoid biogenesis and turnover in plants...
  101. ncbi The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic
    Shih Yin Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    FASEB J 22:2206-13. 2008
    ..Taken together, our results suggest that G6PT has a dual role as a G6P and a P(i) transporter and that GSD-Ib and GSD-Ic are deficient in the same G6PT gene...

Research Grants62

  1. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..abstract_text> ..
  2. pH Regulation in Bacillus subtilis (AREA R15)
    JOAN SLONCZEWSKI; Fiscal Year: 2009
    ..pH vary with external pH? Is intracellular pH recovery enhanced by multidrug transporters and Na+/H+ antiporters? (2) Does pH homeostasis vary among individual cells? Does pH homeostasis depend on the cell cycle and ..
  3. The plant-like vacuole of Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2013
    ..studies further revealed similarities to plant vacuoles such as the presence of a V-H+ATPase, Na? and Ca2? antiporters, and calcium storage...
  4. Ca2+ Transport Mechanism of CaCA Protein Family
    Lei Zheng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ca2+/cation antiporters (CaCAs) are the major secondary Ca2+ transporter proteins in the plasma membrane...
  5. Proton-Coupling Strategies in Alkaliphilic Bacillus
    Terry Ann Krulwich; Fiscal Year: 2013
    ..Specific Aim #2 tests the hypothesis that the 7-protein Mrp hetero-oligomer is a consortium of antiporters and other transporters that are interdependent and synergistic, e.g...
  6. Simulation of Proton Translocation in Biomolecules
    Gregory A Voth; Fiscal Year: 2013
    ..cytochrome c oxidase) enzymes (carbonic anhydrase), channels (M2 proton channels of influenza A and B), and antiporters (ClC chloride/proton antiporters)...
  7. Targeting System Xc- for the Treatment of Addiction
    John R Mantsch; Fiscal Year: 2010
    ..Towards this end, drug-induced changes in glutamate release from cystine-glutamate antiporters have been linked to pathological alterations in neural transmission and normalizing cystine-glutamate exchange ..
  8. Structure and Function of Neurotransmitter Transporters
    James E Gouaux; Fiscal Year: 2013
    ..exchanges one substrate (glutamate) for another (cystine);these transporters are generally referred to as antiporters. Because both symporters and antiporters are highly hydrophobic integral membrane proteins, studies of their ..
  9. Structural Dynamics of Drug/Proton Antiport by a Multidrug Efflux Pump
    PHILLIP RYAN STEED; Fiscal Year: 2013
    ..Drug/H+ antiporters (DHA), part of the major facilitator superfamily (MFS) of secondary transporters, couple the efflux of a ..
  10. Structural Analysis of Multidrug Transport
    Mark E Girvin; Fiscal Year: 2013
    ..The Small Multi-Drug Resistance pumps (SMRs) are 100-110 residue, dimeric proton-drug antiporters that contain the full multidrug transport machinery, stripped to its barest essentials...
  11. MECHANISM FOR CHARGED-RELATED NEPHROTOXICITY
    Darryl Peterson; Fiscal Year: 1993
    ..This raises the possibility that membrane transport proteins, including Na/H antiporters, may be taken up during the endocytic process and become trapped in a pool of endosomes that are not able to ..
  12. Structure and Function of Neurotransmitter Transporters
    JAMES GOUAUX; Fiscal Year: 2009
    ..exchanges one substrate (glutamate) for another (cystine);these transporters are generally referred to as antiporters. Because both symporters and antiporters are highly hydrophobic integral membrane proteins, studies of their ..
  13. CORTICOSTEROID CONTROL OF COLONIC CATION TRANSPORT
    CHRISTINE BASTL; Fiscal Year: 1990
    ..binding studies will be used to determine if glucocorticoids increase the number or affinity of cell membrane antiporters. Measurement of Na+ and H+ flux in colon apical membrane vesicles will determine if glucocorticoids increase ..
  14. GLYCOSYLATION MECHANISMS
    CARLOS HIRSCHBERG; Fiscal Year: 2009
    ..translocatedfrom the cytosol into the lumen of the above organelles via specific transporters which function as antiporters with the corresponding nucleoside monophosphate...
  15. STATIONARY PHASE GENE EXPRESSION IN THE HALOARCHAEA
    RICHARD SHAND; Fiscal Year: 2003
    ..Finally, Spanish researchers have shown that microhalocin H7 inhibits the Na+/H+ antiporters in both haloarchaea and mammals...
  16. The roles of Ptch1 and Disp1 in the formation of the Shh gradient
    Henk Roelink; Fiscal Year: 2013
    ..Ptch1 and Disp1 are members of a large family of trimeric, proton driven antiporters, and in the first aim it is tested if Ptch1 and Disp1 function is required for planar transcytosis of Shh...
  17. CARDIAC SARCOLEMMAL ION TRANSPORT AND THE 15-KDA PROTEIN
    Richard Kovacs; Fiscal Year: 1990
    ..or sarcolemma (SL) regulates ion flux into and out of the cardiac cell through a series of channels, pumps and antiporters. The control of transmembrane ion flux is necessary not only for cellular homeostasis, but also as the means by ..
  18. Cystine-Glu Antiporter & PCP Model of Schizophrenia
    David Baker; Fiscal Year: 2005
    ..contribution of a novel source of glutamate, specifically nonvesicular glutamate release from cystine-glutamate antiporters, to the behavioral and neurochemical effects of phencyclidine (PCP), which represents one of the most commonly ..
  19. GORDON CONFERENCE ON CARDIAC REGULATORY MECHANISMS
    Larry Jones; Fiscal Year: 1992
    ..are planned on cardiac transmembrane signaling, cardiac cell growth and development, ion channels, pumps, and antiporters, excitation/contraction coupling, and the molecular biology of heart failure...
  20. X-ray Structures of Small MDR Efflux Pumps
    Geoffrey Chang; Fiscal Year: 2006
    ..structure of a bacterial multidrug resistance SMR transporter will serve as an excellent model for other 12-TM antiporters that are involved in sugar, ion, amino acid, inorganic, and organic permeation through the membrane...
  21. Structure of Small Multidrug Resistance Transporters
    Owen Pornillos; Fiscal Year: 2005
    ..SMRs act as proton-drug antiporters, and couple drug extrusion to the proton electrochemical gradient across bacterial cell membranes...
  22. Cystine-Glutamate Antiporters and Cocaine Reinstatement
    David Baker; Fiscal Year: 2008
    ..of a novel source of glutamate, specifically nonvesicular glutamate release from cystine- glutamate antiporters, to the behavioral and neurochemical effects of cocaine...
  23. CHARACTERIZATION OF NA-DEPENDENT HCO3-TRANSPORTERS
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation and gene structure of Na-coupled HCO3 transporters should enhance our knowledge on cell regulation and acid-base homeostasis. ..
  24. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
  25. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..They should further facilitate future investigations into the role of this transporter in pathophysiologic states affecting electrolyte and acid-base homeostasis. ..
  26. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..
  27. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in PH1 and the potential roles and interactions of PAT1 and Oxalobacter in modulating the excessive body burden of oxalate in this genetic disease are now possible. ..
  28. 8th International Primary Hyperoxaluria Workshop
    Marguerite Hatch; Fiscal Year: 2007
    ..g. pediatric and adult nephrology, transplant surgery, metabolic medicine, molecular and cell biology, clinical and molecular genetics) to discuss their common interest in Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  29. Tet Efflux Proteins: Implications of Multiple Functions
    TERRY KRULWICH; Fiscal Year: 2004
    ..Specific Aim 3 will: clarify the basis for different phenotypes of tet(L) mutants; will further test the novel translational reinitiation model for tet(L) regulation; and will probe additional, Na- and pH related regulation. ..
  30. Enteric Elimination and Degradation of Oxalic Acid
    Marguerite Hatch; Fiscal Year: 2002
    ..The potential for the clinical application of a novel treatment strategy to reduce urinary oxalate excretion is broad-based and highly significant...
  31. Bacillus anthracis Spores: Initiation of Germination
    TERRY KRULWICH; Fiscal Year: 2003
    ..Such transporters may be new virulence factors, i.e. additional potential therapeutic targets. ..
  32. Enhancing Successful Post-Baccalaureate Intervention to Promote Research Careers
    Terry Ann Krulwich; Fiscal Year: 2010
    ..The studies test hypothesized factors as predictors/builders of successful PhD work and test the adaptability of successful PREP interventions to a doctoral program setting. ..
  33. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    Marguerite Hatch; Fiscal Year: 2002
    ..abstract_text> ..
  34. RECONSTITUTION OF CHANNEL-FORMING PROTEINS
    DAVID RINTOUL; Fiscal Year: 1992
    ..of the molecular mechanisms of cataractogenesis in older human beings, and potentially could represent an entirely new approach to the study of other channel-forming proteins such as neurotransmitter receptors and ion antiporters.
  35. Mechanism of Renal Prostaglandin Transport
    Victor L Schuster; Fiscal Year: 2010
    ..As such, the work offers the potential to open up new approaches to the management of pain, fever, inflammation, hypertension, and a variety of other medical conditions. ..
  36. RBC Ion Transporters as Hemoglobinopathy Risk Modifiers
    Seth Alper; Fiscal Year: 2009
    ..The proposed experiments will increase understanding of sickle cell disease and thalassemia by providing mouse models for genetic tests of new drug therapies under development for near-term clinical testing. ..
  37. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
  38. Genetic Etiology of Sodium-Lithium Countertransport
    Alanna Morrison; Fiscal Year: 2008
    ..e. sodium-lithium countertransport and hypertension, respectively). The goal of the project is the identification of allelic variation influencing sodium-lithium countertransport as well as risk of developing essential hypertension. ..
  39. Cytokines in Sickle Cell Volume Regulation
    Alicia Rivera; Fiscal Year: 2006
    ..abstract_text> ..
  40. ION CHANNEL REGULATION BY THE CYTOPLASMIC TAIL OF PDK1
    Seth Alper; Fiscal Year: 2005
    ..We will search for novel interacting proteins, and prepare protein suitable for structural analysis. ..
  41. ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 2004
    ..abstract_text> ..
  42. Sickle Red Cell K+ Transporter Genetics in S. cerevisiae
    Seth Alper; Fiscal Year: 2002
    ..3) (Provisional Aim): Time permitting, to improve, validate, and standardize growth rescue of trk1delta/trk2delta S. cerevisiae by expression in nonpermissive conditions of cDNA encoding the mammalian IK1 K(ca) channel. ..
  43. MOLECULAR PHYSIOLOGY OF BAND 3 LIKE PROTEINS OF KIDNEY
    Seth Alper; Fiscal Year: 2007
    ..5. Define aspects of transcriptional and translational regulation of AE gene products in kidney of mutant and parental mouse strains and in cultured kidney cells. ..
  44. Cell Signaling in the Kidney
    VICTOR SCHUSTER; Fiscal Year: 2007
    ....
  45. AMINO ACIDS IN NA+, K+, MG2+, AND ATP SITES OF NA+-PUMP
    LARRY FALLER; Fiscal Year: 2001
    ..The conformational change occurs in two steps, ion binding and occlusion, for which intrinsic ion dissociation constants and the equilibrium constant between unoccluded and occluded conformations will be estimated. ..
  46. REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    Daniel Bikle; Fiscal Year: 2001
    ..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
  47. MHC CLASS I ANTIGEN PROCESSING AND PRESENTATION
    Matthew Androlewicz; Fiscal Year: 2001
    ..abstract_text> ..
  48. ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY
    Joyce Solheim; Fiscal Year: 2009
    ..abstract_text> ..
  49. VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    Daniel Bikle; Fiscal Year: 2003
    ..abstract_text> ..
  50. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2005
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  51. A MICROSURGICAL INVESTIGATION OF GASTRIC ACID SECRETION
    John Geibel; Fiscal Year: 2004
    ..abstract_text> ..
  52. MOLECULAR MECHANISMS OF PROXIMAL TUBULE ION TRANSPORT
    PETER ARONSON; Fiscal Year: 2006
    ..nephrolithiasis, osteoporosis) and NaC1 transport (eg. hypertension, congestive heart failure). ..
  53. Modulation of NHE Activity by EPEC Infection
    Pradeep Dudeja; Fiscal Year: 2006
    ..Our findings may aid in the future development of improved therapeutic modalities for infectious diarrhea. [unreadable] [unreadable] [unreadable]..
  54. Transport Physiology of Disease Vector Mosquitoes
    William Harvey; Fiscal Year: 2007
    ..abstract_text> ..
  55. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007
    ..abstract_text> ..
  56. Septate junctional proteins: Proteomic identification and role in diuresis
    KLAUS BEYENBACH; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Human Pigmentation Candidate Gene Variation and Signals of Localized Adaptation
    Heather Norton; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. VISION RESEARCH AT INDIANA UNIVERSITY
    Joseph Bonanno; Fiscal Year: 2008
    ..They include advanced optics of the eye, visual displays for infant vision development, microscopic fluorimetry and imaging, and equipment repair support. [unreadable] [unreadable] [unreadable]..
  59. MECHANISMS AND CONTROL OF ACID RESISTANCE IN E COLI
    John Foster; Fiscal Year: 2004
    ..In a broader sense, knowledge gained from this study will also provide insights into fundamental questions concerning proton circulations, protein structure-function relationships and gene expression as each relates to acid stress ..
  60. MOLECULAR ORGANIZATION OF RENAL ORGANIC CATION TRANSPORT
    Stephen Wright; Fiscal Year: 2008
    ..These studies will be essential for development of models that accurately predict and, ideally, preempt unwanted interactions of cationic drugs in both the kidney and liver. ..
  61. TRANSPORT BY OCULAR EPITHELIAL CELLS
    MORTIMER CIVAN; Fiscal Year: 2005
    ..abstract_text> ..