lactoferrin

Summary

Summary: An iron-binding protein in plasma and secretions (milk, mucus, bile), secreted by leukocytes. It is an important component of GRANULOCYTES. It is bacteriostatic, working by depriving bacteria of iron essential for growth.

Top Publications

  1. ncbi Large scale production of recombinant human lactoferrin in the milk of transgenic cows
    Patrick H C van Berkel
    Pharming, Leiden, The Netherlands
    Nat Biotechnol 20:484-7. 2002
  2. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
  3. ncbi Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual role
    J A Khan
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi, 110029, India
    J Mol Biol 309:751-61. 2001
  4. ncbi Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a prospective multicentre comparison of predicting outcomes and monitoring response
    D Turner
    Paediatric Gastroenterology and Nutrition Unit, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, POB 3235, Jerusalem 91031, Israel
    Gut 59:1207-12. 2010
  5. ncbi The physiology of lactoferrin
    Jeremy H Brock
    Department of Immunology and Bacteriology, Western Infirmary, Glasgow, United Kingdom
    Biochem Cell Biol 80:1-6. 2002
  6. ncbi Fecal lactoferrin is a sensitive and specific marker of disease activity in children and young adults with inflammatory bowel disease
    Thomas R Walker
    Center for Inflammatory Bowel Disease, Harvard Medical School, Boston, MA, USA
    J Pediatr Gastroenterol Nutr 44:414-22. 2007
  7. ncbi Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus
    Sivaraman Arumugam Balasubramanian
    Brien Holden Vision Institute, Sydney, NSW 2052, Australia
    Exp Eye Res 96:132-7. 2012
  8. ncbi Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties
    Dominique Legrand
    Unite de Glycobiologie Structurale et Fonctionnelle, Institut Fédératif de Recherche no 118, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Biometals 17:225-9. 2004
  9. ncbi Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution
    B F Anderson
    Department of Chemistry and Biochemistry, Massey University, Palmerston North, New Zealand
    J Mol Biol 209:711-34. 1989
  10. ncbi Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin
    Marieke I A van der Kraan
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam ACTA, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    Peptides 25:177-83. 2004

Detail Information

Publications360 found, 100 shown here

  1. ncbi Large scale production of recombinant human lactoferrin in the milk of transgenic cows
    Patrick H C van Berkel
    Pharming, Leiden, The Netherlands
    Nat Biotechnol 20:484-7. 2002
    ..Here we describe the production of recombinant human lactoferrin (rhLF), an iron-binding glycoprotein involved in innate host defense, at gram per liter concentrations in ..
  2. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    The aim of this study was to compare the performance of fecal lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (..
  3. ncbi Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual role
    J A Khan
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi, 110029, India
    J Mol Biol 309:751-61. 2001
    Camel lactoferrin is the first protein from the transferrin superfamily that has been found to display the characteristic functions of iron binding and release of lactoferrin as well as transferrin simultaneously...
  4. ncbi Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a prospective multicentre comparison of predicting outcomes and monitoring response
    D Turner
    Paediatric Gastroenterology and Nutrition Unit, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, POB 3235, Jerusalem 91031, Israel
    Gut 59:1207-12. 2010
    ..To compare four faecal markers for their ability to predict steroid refractoriness in severe paediatric ulcerative colitis (UC). Construct validity and responsiveness to change were also assessed...
  5. ncbi The physiology of lactoferrin
    Jeremy H Brock
    Department of Immunology and Bacteriology, Western Infirmary, Glasgow, United Kingdom
    Biochem Cell Biol 80:1-6. 2002
    This paper reviews our current knowledge of the structure and function of the iron-binding protein lactoferrin. In particular, it attempts to relate the various proposed physiological functions of lactoferrin to its most characteristic ..
  6. ncbi Fecal lactoferrin is a sensitive and specific marker of disease activity in children and young adults with inflammatory bowel disease
    Thomas R Walker
    Center for Inflammatory Bowel Disease, Harvard Medical School, Boston, MA, USA
    J Pediatr Gastroenterol Nutr 44:414-22. 2007
    Fecal lactoferrin (FLA) is a neutrophil-derived surrogate marker of intestinal inflammation that is elevated in patients with inflammatory bowel disease...
  7. ncbi Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus
    Sivaraman Arumugam Balasubramanian
    Brien Holden Vision Institute, Sydney, NSW 2052, Australia
    Exp Eye Res 96:132-7. 2012
    ..This study was designed to examine the levels of total protein, lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus...
  8. ncbi Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties
    Dominique Legrand
    Unite de Glycobiologie Structurale et Fonctionnelle, Institut Fédératif de Recherche no 118, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Biometals 17:225-9. 2004
    b>Lactoferrin is a member of the transferrin family of iron-binding glycoproteins that is abundantly expressed and secreted from glandular epithelial cells...
  9. ncbi Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution
    B F Anderson
    Department of Chemistry and Biochemistry, Massey University, Palmerston North, New Zealand
    J Mol Biol 209:711-34. 1989
    The structure of human lactoferrin has been refined crystallographically at 2.8 A (1 A = 0.1 nm) resolution using restrained least squares methods. The starting model was derived from a 3...
  10. ncbi Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin
    Marieke I A van der Kraan
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam ACTA, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    Peptides 25:177-83. 2004
    The antimicrobial activity of bovine lactoferrin is attributed to lactoferricin, situated in the N1-domain...
  11. ncbi Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 14:40-6. 2008
    Correlation of endoscopic Crohn's disease activity with fecal calprotectin and lactoferrin is insufficiently studied...
  12. ncbi Molecular structure, binding properties and dynamics of lactoferrin
    E N Baker
    School of Biological Sciences and Department of Chemistry, University of Auckland, New Zealand
    Cell Mol Life Sci 62:2531-9. 2005
    b>Lactoferrin (Lf), a prominent protein in milk, many other secretory fluids and white blood cells, is a monomeric, 80-kDa glycoprotein, with a single polypeptide chain of about 690 amino acid residues...
  13. ncbi A critical review of the roles of host lactoferrin in immunity
    Dominique Legrand
    Structural and Functional Glycobiology Unit, UMR 8576 CNRS USTL, IFR 147, Batiment C9, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Biometals 23:365-76. 2010
    b>Lactoferrin (Lf) is an essential element of innate immunity, which refers to antigen-nonspecific defense mechanisms that a host uses immediately or within hours after exposure to an antigen...
  14. pmc Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection
    Richard M Novak
    University of Illinois at Chicago, 808 S Wood St, M C 735, Rm 888, Chicago, IL 60612, USA
    Clin Vaccine Immunol 14:1102-7. 2007
    ..This study examined the levels of three such factors, genital tract lactoferrin [Lf], secretory leukocyte protease inhibitor [SLPI], and RANTES, in women at risk for acquiring HIV infection, ..
  15. ncbi miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells
    Yalin Liao
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 140:1552-6. 2010
    b>Lactoferrin (Lf) is an abundantly expressed protein in human milk. Lactoferrin exhibits several important biological functions, and its expression is regulated by multiple environmental factors...
  16. ncbi Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial
    Paolo Manzoni
    Neonatology and Neonatal Intensive Care Unit, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    JAMA 302:1421-8. 2009
    ..Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is ..
  17. ncbi Lactoferrin-conjugated superparamagnetic iron oxide nanoparticles as a specific MRI contrast agent for detection of brain glioma in vivo
    Hui Xie
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Biomaterials 32:495-502. 2011
    ..This study explored lactoferrin-conjugated superparamagnetic iron oxide nanoparticles (Lf-SPIONs) as an MRI contrast agent for the detection of ..
  18. ncbi Cancer prevention by bovine lactoferrin: from animal studies to human trial
    Hiroyuki Tsuda
    Nanotoxicology Project, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Biometals 23:399-409. 2010
    ..Administration of bovine lactoferrin (bLF) suppresses carcinogenesis in the colon and other organs of test animals, and recently it was shown that ..
  19. ncbi Lactoferrin and iron: structural and dynamic aspects of binding and release
    Heather M Baker
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Biometals 17:209-16. 2004
    b>Lactoferrin (Lf) has long been recognized as a member of the transferrin family of proteins and an important regulator of the levels of free iron in the body fluids of mammals...
  20. ncbi Suppressive effects of milk-derived lactoferrin on psychological stress in adult rats
    Nao Kamemori
    Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori 680 0945, Japan
    Brain Res 1029:34-40. 2004
    b>Lactoferrin (LF) is known as an iron-binding glycoprotein. It has been shown that bovine LF (bLF) is transported into cerebrospinal fluid via blood although its physiological effects in the central nervous system (CNS) are still unclear...
  21. pmc Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice
    Pauline P Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Pathol 172:1019-29. 2008
    b>Lactoferrin (LF) is an iron-binding protein found in milk, mucosal secretions, and the secondary granules of neutrophils in which it is considered to be an important factor in the innate immune response against microbial infections...
  22. ncbi Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial
    Paolo Manzoni
    Department of Neonatology and NICU, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    Pediatrics 129:116-23. 2012
    b>Lactoferrin is a mammalian milk glycoprotein involved in innate immunity. Recent data show that bovine lactoferrin (bLF) prevents late-onset sepsis in preterm very low birth weight (VLBW) neonates.
  23. pmc Quantitative fecal lactoferrin in toxin-positive and toxin-negative Clostridium difficile specimens
    P Rocco Lasala
    Department of Pathology, Robert C Byrd Health Sciences Center, West Virginia University, and Clinical Laboratory, West Virginia University Healthcare, Morgantown, West Virginia, USA
    J Clin Microbiol 51:311-3. 2013
    Quantitative fecal lactoferrin was measured in 112 patients tested for toxigenic Clostridium difficile using glutamate dehydrogenase (GDH) and toxin immunoassays combined with tcdB PCR...
  24. ncbi Fecal lactoferrin as a noninvasive biomarker in inflammatory bowel diseases
    J Langhorst
    Department of Internal and Integrative Medicine, University of Duisburg Essen, Essen, Germany
    Drugs Today (Barc) 48:149-61. 2012
    ..e., Crohn's disease and ulcerative colitis, still present a number of challenges. The fecal biomarker lactoferrin has been shown to be useful in the diagnosis and management of these diseases...
  25. ncbi Inhibition of Epstein-Barr virus infection by lactoferrin
    Ying Zheng
    Cancer Research Institute, Central South University, Changsha, China
    J Innate Immun 4:387-98. 2012
    b>Lactoferrin (LF) is a multifunctional glycoprotein that plays an important role in native immune defense against infections, including human herpetic viruses, such as cytomegalovirus and herpes simplex virus types 1 and 2...
  26. ncbi Human lactoferrin exerts bi-directional actions on PC12 cell survival via ERK1/2 pathway
    Tsung Yao Lin
    Laboratory of Biophysics, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochem Biophys Res Commun 337:330-6. 2005
    Human lactoferrin (hLF) is a member of the transferrin family and is found in most body fluids of human. Recent study showed that hLF played some roles in the regulation of cell growth...
  27. pmc Efficient generation of feasible pathways for protein conformational transitions
    Moon K Kim
    Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 83:1620-30. 2002
    ..readily made to large proteins, and we demonstrate our method on lactate dehydrogenase, citrate synthase, and lactoferrin. We also illustrate how this framework can be used to complement experimental techniques that partially observe ..
  28. pmc Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall
    J Gobin
    Department of Medicine, School of Medicine, University of California, Los Angeles 90095, USA
    J Exp Med 183:1527-32. 1996
    ..whether it was 95 or 40% iron saturated, its approximate percent saturation in human serum, and from human lactoferrin. Desferri-exochelins also removed iron, but at a slower rate, from the iron storage protein ferritin...
  29. ncbi Lactoferrin, a key molecule in immune and inflammatory processes
    Dominique Legrand
    UMR 8576 CNRS Université des Sciences et Technologies de Lille, Unite de Glycobiologie Structurale et Fonctionnelle, IFR 147, F 59650 Villeneuve d Ascq, France
    Biochem Cell Biol 90:252-68. 2012
    b>Lactoferrin (Lf) belongs to the family of antimicrobial molecules that constitute the principal defense line of nonvertebrate organisms...
  30. ncbi Lactoferrin structure and functions
    Dominique Legrand
    Unité de Glycobiologie Structurale et Fontionnelle, UMR 8576 du CNRS, IFR 147, Université des Sciences et des Technologies de Lille, F 59655 Villeneuve d Ascq Cedex, France
    Adv Exp Med Biol 606:163-94. 2008
    b>Lactoferrin (Lf) is an iron binding glycoprotein of the transferrin family that is expressed in most biological fluids and is a major component of mammals' innate immune system...
  31. ncbi Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer
    Rupinder K Kanwar
    Nanomedicine Laboratory of Immunology and Molecular Biomedical Research LIMBR, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria 3216, Australia
    Protein Pept Lett 20:450-8. 2013
    b>Lactoferrin (Lf), an iron binding ~80 kDa glycoprotein is a well characterized multifunctional protein found to be present in mammalian milk and in most exocrine secretions...
  32. ncbi Iron sequestration by human lactoferrin stimulates P. aeruginosa surface motility and blocks biofilm formation
    Pradeep K Singh
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biometals 17:267-70. 2004
    This paper summarizes a presentation at the 6th International Conference on Lactoferrin Structure and Function. Some of this data has been previously published.
  33. ncbi Biochemical and molecular impacts of lactoferrin on small intestinal growth and development during early life
    Yalin Liao
    Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Biochem Cell Biol 90:476-84. 2012
    ..b>Lactoferrin (Lf) is among the various human milk trophic factors that facilitate the infant intestinal adaptation...
  34. ncbi Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles
    Rongqin Huang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
    J Gene Med 11:754-63. 2009
    ..We previously constructed a lactoferrin (Lf)-modified vector, which was demonstrated to be potential for brain gene delivery both in vitro and in vivo...
  35. ncbi Inhibitory effects of native and recombinant full-length camel lactoferrin and its N and C lobes on hepatitis C virus infection of Huh7.5 cells
    Yalin Liao
    Department of Nutrition, University of California, Davis, USA
    J Med Microbiol 61:375-83. 2012
    b>Lactoferrin has been suggested to have antiviral activity against hepatitis C virus (HCV)...
  36. ncbi Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations
    Kaili Hu
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 200032, People s Republic of China
    J Control Release 134:55-61. 2009
    The lactoferrin (Lf) conjugated poly (ethyleneglycol)-poly (lactide) nanoparticle (Lf-NP) was constructed in this paper as a novel biodegradable brain drug delivery system with evaluation of its in vitro and in vivo delivery properties...
  37. ncbi Lactoferrin: structure, function and applications
    Susana A González-Chávez
    Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Cd Universitaria s n, CP 31170, Chihuahua, Chihuahua, Mexico
    Int J Antimicrob Agents 33:301.e1-8. 2009
    b>Lactoferrin (LF) is an 80 kDa iron-binding glycoprotein of the transferrin family that is expressed in most biological fluids and is a major component of the mammalian innate immune system...
  38. ncbi Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts
    J H Andersen
    Department of Microbiology, University Hospital of Tromsø, N 9038 Tromsø, Norway
    Antiviral Res 51:141-9. 2001
    b>Lactoferrin is mainly produced by polymorphonuclear leukocytes and has been demonstrated in mammalian milk and external secretions...
  39. ncbi The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain
    Rongqin Huang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Biomaterials 29:238-46. 2008
    Development of an efficient gene vector is a key-limiting factor of brain gene therapy. In this study, lactoferrin (Lf), for the first time, was investigated as a brain-targeting ligand in the design of polyamidoamine (PAMAM)-based non-..
  40. ncbi Antitumour activity and specificity as a function of substitutions in the lipophilic sector of helical lactoferrin-derived peptide
    Nannan Yang
    Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    J Pept Sci 9:300-11. 2003
    A peptide L5 (PAWRKAFRWAWRMLKKAA), derived from the N-terminal alpha-helical region of bovine lactoferrin (LFB 14-31), that is highly active against several tumour cell lines was reported earlier...
  41. ncbi Enhanced antitumor activity and selectivity of lactoferrin-derived peptides
    N Yang
    Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    J Pept Res 60:187-97. 2002
    A number of peptide analogs derived from the N-terminal alpha-helical region of bovine lactoferrin (LFB 14-31), were designed in order to investigate how deviating numbers and positions of positively charged residues and numbers of ..
  42. pmc The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells
    Bodil Fadnes
    Department of Medical Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    BMC Cancer 9:183. 2009
    ..The purpose of this study was to investigate the role of the two GAGs in the cytotoxic activity of CAPs...
  43. ncbi Opposing selective forces for expression of the gonococcal lactoferrin receptor
    James E Anderson
    Department of Medicine, School of Medicine, University of North Carolina, 521 Burnett Womack Building, CB 7030, Chapel Hill 27599, USA
    Mol Microbiol 48:1325-37. 2003
    All isolates of Neisseria gonorrhoeae express receptors that bind human transferrin (Tf). Although lactoferrin (Lf) is abundant on mucosa and in purulent exudates, many gonococci do not express an Lf receptor...
  44. pmc Lactoferrin as a natural immune modulator
    Jeffrey K Actor
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, TX 77030, USA
    Curr Pharm Des 15:1956-73. 2009
    b>Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals...
  45. ncbi Lactoferrin--a multifunctional protein with antimicrobial properties
    Sebastien Farnaud
    Metalloprotein Research Group, Randall Centre for Molecular Mechanisms of Cell Function, King s College London, 3 6 A New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Mol Immunol 40:395-405. 2003
    b>Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been reported and continue to be reported for the protein, some of which are related to its iron-binding properties...
  46. ncbi Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties
    J L Gifford
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Alberta, Canada
    Cell Mol Life Sci 62:2588-98. 2005
    The peptide lactoferricin (Lfcin) can be released from the multifunctional protein lactoferrin (LF) through proteolysis by pepsin under acidic conditions, a reaction that occurs naturally in the stomach...
  47. ncbi Fecal calprotectin, lactoferrin, and endoscopic disease activity in monitoring anti-TNF-alpha therapy for Crohn's disease
    Taina Sipponen
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Inflamm Bowel Dis 14:1392-8. 2008
    Fecal calprotectin and lactoferrin are promising noninvasive biomarkers for intestinal inflammation...
  48. ncbi Recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonatal mice from a lethal challenge with enterovirus type 71
    Hsiao Ling Chen
    Department of Molecular Biotechnology, Da Yeh University, Changhwa 51501, Taiwan
    Vaccine 26:891-8. 2008
    ..In this study, we developed a transgenic mouse model for demonstrating the protective effects of recombinant lactoferrin (LF) against EV71 infection...
  49. ncbi Antimicrobial properties of lactoferrin
    Håvard Jenssen
    Centre for Microbial Diseases and Immunity Research, 232 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    Biochimie 91:19-29. 2009
    ..In addition to its nutritional value, it is a rich source of proteins including lactoferrin. Lactoferrin is a truly multifunctional protein that has been studied extensively over the past decades...
  50. ncbi Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment
    Jamie S Mader
    Dalhousie University, Department of Pathology, Faculty of Medicine, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, B3H 1X5, Canada
    Expert Opin Investig Drugs 15:933-46. 2006
    ..This article reviews the mechanisms by which CAPs exert anticancer activity and discusses the potential application of selected CAPs as therapeutic agents for the treatment of human cancers...
  51. ncbi Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro
    Tzou Yien Lin
    Department of Pediatrics, Chang Gung Children s Hospital, 5 Fu Hsin Street, Kweishan 333, Taoyuan, Taiwan
    J Infect Dis 186:1161-4. 2002
    ..5-24.5 microg/mL and 103.3-185.0 microg/mL, respectively). Lactoferrin probably exerts its effect at the level of viral adsorption, since the ongoing infection could not be further ..
  52. ncbi Lactoferrin: an important host defence against microbial and viral attack
    P Valenti
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Italy
    Cell Mol Life Sci 62:2576-87. 2005
    The first function attributed to lactoferrin (Lf), an iron binding protein belonging to the non-immune natural defences, was antimicrobial activity that depended on its capacity to sequester iron...
  53. pmc Investigation of the human tear film proteome using multiple proteomic approaches
    Kari B Green-Church
    Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 14:456-70. 2008
    ....
  54. ncbi Immunomodulatory effects of lactoferrin on antigen presenting cells
    Patrizia Puddu
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 91:11-8. 2009
    b>Lactoferrin (Lf) is an 80 kDa iron-binding protein of the transferrin family that is abundantly expressed in most biological fluids...
  55. pmc Bovine lactoferricin inhibits basic fibroblast growth factor- and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells
    Jamie S Mader
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5 Canada
    Am J Pathol 169:1753-66. 2006
    ..Bovine lactoferricin (LfcinB) is a peptide fragment of iron- and heparin-binding lactoferrin obtained from cow's milk...
  56. pmc Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
    Renji Reghunathan
    Department of Physiology, National University of Singapore, Singapore
    BMC Immunol 6:2. 2005
    ..To understand the host response to this pathogen, we investigated the gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from SARS patients, and compared with healthy controls...
  57. ncbi Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis
    Jost Langhorst
    Department of Internal Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Essen, Germany
    Inflamm Bowel Dis 11:1085-91. 2005
    To evaluate the diagnostic use of fecal concentrations of lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil-elastase (PMN-e), and lysozyme (Lys) as indicators of disease activity in patients with active and inactive ..
  58. pmc The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii
    Lenie Dijkshoorn
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Antimicrob Agents Chemother 48:4919-21. 2004
    The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an ..
  59. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
    ..tested proteins from milk and serum for their ability to block DC-mediated HIV-1 transmission, of which bovine lactoferrin (bLF) is the most potent inhibitor...
  60. ncbi Evidence for a direct antitumor mechanism of action of bovine lactoferricin
    Liv Tone Eliassen
    Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Anticancer Res 22:2703-10. 2002
    Bovine lactoferrin (LFB) and its pepsin-generated peptide lactoferricin (LfcinB) possess antitumor activities. The mechanism underlying the antitumor activities of LfcinB in vivo has not been elucidated...
  61. ncbi Relationships among salivary immunoglobulin A, lactoferrin and cortisol in basketball players during a basketball season
    Cheng Shiun He
    Department of Physical Education, National Taichung University, Taichung, Taiwan
    Eur J Appl Physiol 110:989-95. 2010
    ..Salivary immunoglobulin A (sIgA), cortisol, and lactoferrin were measured during training and competition period and compared with those measured at the fourth recovery ..
  62. ncbi Antiviral properties of lactoferrin--a natural immunity molecule
    Francesca Berlutti
    Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome 00185, Italy
    Molecules 16:6992-7018. 2011
    b>Lactoferrin, a multifunctional iron binding glycoprotein, plays an important role in immune regulation and defence mechanisms against bacteria, fungi and viruses...
  63. pmc Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells
    Rulan Jiang
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Cell Physiol 226:3022-31. 2011
    b>Lactoferrin (Lf) is a major iron-binding and multi-functional protein in exocrine fluids such as breast milk and mucosal secretions...
  64. pmc Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcγ receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity
    Constantine Bitsaktsis
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Infect Immun 80:1166-80. 2012
    ..Immune serum also showed an enhanced bactericidal activity directed against S. pneumoniae that appears to be lactoferrin mediated.
  65. ncbi Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells
    Chan Woo Kim
    College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin 446 701, Republic of Korea
    FEBS Lett 586:229-34. 2012
    b>Lactoferrin (Lf) is known to have anti-inflammatory activity, but the mechanisms of action by Lf remain to be elucidated...
  66. ncbi Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs)
    Rafia Mir
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
    Arch Biochem Biophys 500:196-202. 2010
    ..In order to minimize these side effects, C-terminal half (C-lobe) of colostrum protein lactoferrin has been indicated to be useful if co-administered with NSAIDs...
  67. pmc Lactoferrin decreases pollen antigen-induced allergic airway inflammation in a murine model of asthma
    Marian L Kruzel
    PharmaReview Corporation, Inc, Houston, TX, USA
    Immunology 119:159-66. 2006
    ..The aim of the study was to examine the impact of lactoferrin (LF), an iron-binding protein, on ragweed (Ambrosia artemisiifolia) pollen extract (RWE)-induced cellular ..
  68. ncbi Mammalian lactoferrin receptors: structure and function
    Y A Suzuki
    Department of Nutrition, University of California, Davis, 95616, USA
    Cell Mol Life Sci 62:2560-75. 2005
    Mammalian lactoferrin (Lf) receptors are suggested to have pivotal roles for mediating multiple functions of Lf...
  69. ncbi Human neutrophil lactoferrin trans-activates the matrix metalloproteinase 1 gene through stress-activated MAPK signaling modules
    S M Oh
    Division of Life Sciences, Graduate School of Biotechnology, Korea University, Seoul 136-701, Korea
    J Biol Chem 276:42575-9. 2001
    It has been proposed that human neutrophil lactoferrin (Lf) could be involved in gene expression as a DNA-binding protein after its translocation into the nucleus...
  70. ncbi In vitro interaction between ceruloplasmin and human serum transferrin
    Nguyêt Thanh Ha-Duong
    Laboratoire ITODYS Interfaces, Traitements et Organisation des Systèmes, Université Paris Diderot, CNRS UMR 7086, Bâtiment Lavoisier, 15 rue Jean Antoine de Baïf, Paris Cedex 13, France
    Biochemistry 49:10261-3. 2010
    ..of serum apotransferrin (T) and holotransferrin (TFe(2)) with ceruloplasmin (Cp), as well as those of human lactoferrin (Lf), were assessed by fluorescence emission spectroscopy. Cp interacts with two Lf molecules...
  71. ncbi CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery
    Peter Gessler
    University Children s Hospital, Zurich, Switzerland
    Shock 22:513-20. 2004
    ..Plasma levels of chemokines, myeloperoxidase (MPO), and lactoferrin were measured by immunoassays. Cell surface receptors were detected by flow cytometry...
  72. ncbi Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation
    Sunanda V Kane
    University of Chicago, Chicago, Illinois 60637, USA
    Am J Gastroenterol 98:1309-14. 2003
    b>Lactoferrin is a glycoprotein expressed by activated neutrophils...
  73. ncbi Lactoferrin and its hydrolysate bind directly to the oleate-activated form of the lipolysis stimulated lipoprotein receptor
    Nazir Ahmad
    Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux, Vandœuvre les Nancy cedex, France
    FEBS J 279:4361-73. 2012
    ..The milk protein, lactoferrin, has been shown to inhibit hepatic chylomicron remnant removal by the liver, resulting in increased ..
  74. ncbi Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor
    Yu Tang Tung
    Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan
    J Dairy Sci 96:2095-106. 2013
    ..In this study, bovine lactoferrin (bLF) was used in both in vitro and in vivo approaches to investigate its activity against lung cancer...
  75. ncbi Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Kanagawa, Japan
    Biosci Biotechnol Biochem 63:955-7. 1999
    Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial peptide derived from bovine LF, inhibited thiobarbituric acid-reactive substance (TBARS) formation in a iron/ascorbate-induced liposomal phospholipid peroxidation ..
  76. ncbi Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line
    Shin Hee Lee
    School of Life Sciences and Biotechnology, Korea University, 5 Anam dong Sungbuk gu, Seoul 136 701, Republic of Korea
    Biochimie 91:102-8. 2009
    The cell proliferation of p53-deficient Jurkat T cells is controlled after prolonged exposure to human lactoferrin (Lf). However, the molecular mechanism by which Lf influences these cellular responses remains unclear...
  77. ncbi Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1961-6. 2004
    Bovine lactoferrin, a multifunctional glycoprotein, has been shown to strongly inhibit development of azoxymethane (AOM)-induced rat colon tumors. Little, however, is known about the inhibitory mechanisms...
  78. ncbi Helicobacter pylori eradication with either quadruple regimen with lactoferrin or levofloxacin-based triple therapy: a multicentre study
    A Zullo
    Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
    Dig Liver Dis 39:806-10. 2007
    ..A quadruple therapy with lactoferrin and a levofloxacin-based triple therapy has been found to achieve a very high (>90%) cure rate...
  79. ncbi Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status
    José María Moreno-Navarrete
    Unit of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, and CIBER Fisiopatologia Obesidad y Nutricion CB06 03 010, Instituto de Salud Carlos III, Girona, Spain
    Clin Chem 54:301-9. 2008
    b>Lactoferrin, an innate immune protein with antiinflammatory properties, shows considerable antiatherosclerosis activity in animal studies...
  80. ncbi Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
    Our previous study revealed that lactoferrin (LF) significantly increases mobilization of the myelocytic lineage in mice...
  81. ncbi Requirement for IFN-gamma, CD8+ T lymphocytes, and NKT cells in talactoferrin-induced inhibition of neu+ tumors
    Michela Spadaro
    Molecular Biotechnology Center, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Cancer Res 67:6425-32. 2007
    We have previously shown that talactoferrin-alfa (TLF), a recombinant human lactoferrin, is an immunomodulatory protein that is active against implanted tumors, both as a single agent and in combination with chemotherapy...
  82. ncbi Antibiotic properties and applications of lactoferrin
    Eugene D Weinberg
    Department of Biology and Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA
    Curr Pharm Des 13:801-11. 2007
    b>Lactoferrin (Lf), a mammalian iron scavenging defense protein, constitutively is present in exocrine secretions that consistently are exposed to microbial flora: milk, tears, tubotympanum and nasal exudate, saliva, bronchial mucus, ..
  83. ncbi Enhancement of nisin, lysozyme, and monolaurin antimicrobial activities by ethylenediaminetetraacetic acid and lactoferrin
    Jill K Branen
    Department of Food Science and Toxicology, University of Idaho, Moscow, ID 83844 2201, USA
    Int J Food Microbiol 90:63-74. 2004
    ..assay was employed to systematically assess the interaction between ethylenediaminetetraacetic acid (EDTA) or lactoferrin and nisin, lysozyme, or monolaurin against strains of Listeria monocytogenes, Escherichia coli, Salmonella ..
  84. ncbi Lactoferrin in Sjögren's syndrome
    Murat Dogru
    Ophthalmology 114:2366-7. 2007
  85. ncbi Pulsed ELDOR determination of the intramolecular distance between the metal binding sites in Dicupric human serum transferrin and lactoferrin
    Christopher W M Kay
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Am Chem Soc 129:4868-9. 2007
  86. ncbi Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide
    Bostjan Japelj
    Department of Biotechnology, National Institute of Chemistry, 1000 Ljubljana, Slovenia
    J Biol Chem 280:16955-61. 2005
    ..Short linear antimicrobial and endotoxin-neutralizing peptide LF11, based on the human lactoferrin, binds to LPS, inducing a peptide fold with a "T-shaped" arrangement of a hydrophobic core and two ..
  87. ncbi Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women
    Rosalba Paesano
    Department of Obstetrician and Gynecology, University of Rome La Sapienza, Via di Grottarossa 1035, 00189 Roma, Italy
    Biochem Cell Biol 84:377-80. 2006
    ..enrolled in a trial of oral administration of ferrous sulfate (520 mg once a day) or 30% iron-saturated bovine lactoferrin (bLf) (100 mg twice a day). Pregnant women refusing treatment represented the control group...
  88. ncbi Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers
    F J Troost
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Clin Nutr 57:1579-85. 2003
    To determine whether recombinant human lactoferrin ingestion inhibits nonsteroidal antiinflammatory drugs (NSAID)-induced gastroenteropathy in vivo in healthy volunteers as a model for disorders associated with a rise in permeability of ..
  89. pmc The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus
    Yasushi A Suzuki
    Department of Nutrition, University of California, Davis, California 95616, USA
    Biochemistry 47:10915-20. 2008
    Human lactoferrin (hLf) has been shown to interact with cells from the Caco-2 human small intestinal cell line. There currently is little information about the molecular details of its interaction...
  90. ncbi Ultrastructural effects of antimicrobial peptides from bovine lactoferrin on the membranes of Candida albicans and Escherichia coli
    Marieke I A van der Kraan
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam ACTA, Vrije Universiteit and Universiteit van Amsterdam, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Peptides 26:1537-42. 2005
    Antimicrobial peptides allegedly exert their action on microbial membranes. Bovine lactoferrin enfold two antimicrobial domains, lactoferricin B (LFcin B) and lactoferrampin (LFampin)...
  91. ncbi Release of calcium from intracellular stores and subsequent uptake by mitochondria are essential for the candidacidal activity of an N-terminal peptide of human lactoferrin
    Antonella Lupetti
    Department of Infectious Diseases, C5 P, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Antimicrob Chemother 54:603-8. 2004
    ..showed that mitochondrial damage is a hallmark of the candidacidal activity of an N-terminal peptide of human lactoferrin, further referred to as hLF(1-11)...
  92. ncbi Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissues
    Romy Fischer
    INRA, UMR 914 Nutrition Physiology and Ingestive Behavior, AgroParisTech, 16 rue Claude Bernard, F75231 Paris Cedex 05, France
    Int Immunopharmacol 7:1387-93. 2007
    b>Lactoferrin is a glycoprotein with antimicrobial and immunoregulatory properties, which is found in milk, other external secretions, and in the secondary granules of neutrophils...
  93. pmc Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin
    Penghua Yang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 3:e3453. 2008
    ..We describe here the use of cattle mammary bioreactor to produce functional recombinant human lactoferrin (rhLF) by a novel procedure of transgenic cloning, which employs microinjection to generate transgenic somatic ..
  94. ncbi Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats
    T Fujihara
    Santen Pharmaceutical Co, Ltd Nara Research and Development Center, Ikoma shi, Japan
    Cornea 19:207-11. 2000
    b>Lactoferrin supplementation suppresses ultraviolet light B (UV-B)-induced oxidation of cultures of human corneal epithelial cells...
  95. ncbi Lactoferrin as a natural regimen for selective decontamination of the digestive tract: recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonates from pathogenic challenge in the gastrointestinal tract
    Chih Ching Yen
    Department of Life Sciences, National Chung Hsing University, China Medical University Hospital, Taichung, Taiwan
    J Infect Dis 199:590-8. 2009
    ..In the present study, we performed pathogenic challenges of the digestive tract in a transgenic milk-fed animal model to test whether porcine lactoferrin (pLF) is an effective SDD regimen.
  96. ncbi Orally administered lactoferrin preserves bone mass and microarchitecture in ovariectomized rats
    Hui Yuan Guo
    College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
    J Nutr 139:958-64. 2009
    b>Lactoferrin (LF) is reported to stimulate osteoblast proliferation and inhibit osteoclast activity in bone cell culture. However, the effect of oral LF on bone in osteoporosis needs to be explored...
  97. pmc Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread
    Hannamari Valimaa
    Institute of Dentistry, University of Turku, Turku, Finland
    Virol J 6:53. 2009
    ..In the current study, we investigated the anti-HSV-1 activity of human lactoferrin (hLf) and lysozyme (hLz), two highly cationic polypeptides of the mucosal innate defence system...
  98. ncbi Gastric digestion of bovine lactoferrin in vivo in adults
    F J Troost
    Department of Human Biology, Nutrition and Toxicology Institute Maastricht, Universiteitssingel, Maastricht, The Netherlands
    J Nutr 131:2101-4. 2001
    b>Lactoferrin (LF), an iron-binding glycoprotein present in milk and other endocrine and exocrine secretions, may exert a number of physiologic effects in the intestines...
  99. ncbi Lactoferrin derived peptides: mechanisms of action and their perspectives as antimicrobial and antitumoral agents
    Anna Rita Lizzi
    University of L Aquila, Coppito L Aquila, Italy
    Mini Rev Med Chem 9:687-95. 2009
    ..In the wide AMPs panorama a particular position is occupied by lactoferrin derived peptides...
  100. ncbi Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling
    Ken Ando
    Tokyo University of Pharmacy and Life Sciences, Japan
    FEBS J 277:2051-66. 2010
    b>Lactoferrin (LF) has been implicated in innate immunity. Here we reveal the signal transduction pathway responsible for human LF (hLF)-triggered nuclear factor-kappaB (NF-kappaB) activation...
  101. ncbi Signal transduction and metabolism in chondrocytes is modulated by lactoferrin
    N Brandl
    Medical University of Vienna, Center Physiology and Pathophysiology, Vienna, Austria
    Osteoarthritis Cartilage 18:117-25. 2010
    Activation of granulocytes causes a considerable rise in the concentration of lactoferrin (Lf) in synovial fluid (SF)...

Research Grants66

  1. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This project aims to develop talactoferrin (TLF, recombinant human lactoferrin) as a therapeutic agent to treat prematurely born neonates...
  2. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..a biologic therapeutic to treat systemic inflammatory response syndrome (SIRS) using a novel human recombinant lactoferrin that contains "humanized" glycosylation patterns...
  3. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..tb growth. In vivo, most extracellular Fe is chelated to transferrin (TF) and lactoferrin (LF), decreasing microbial access to Fe. We find that M...
  4. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..to bind human complement factor H (FH) and the ectodomain of pIgR and the ability of PspA to bind apo- and holo-lactoferrin (LF) and to inhibit complement deposition...
  5. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2013
    ..means by which Bordetella cells use host neuroendocrine stress hormones to obtain the iron from transferrin and lactoferrin. PUBLIC HEALTH RELEVANCE: Nearly all bacteria require iron for growth and pathogenic bacteria must be able to ..
  6. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..Our preliminary studies demonstrate that lactoferrin (LF) suppresses alcohol-induced gut hyper-permeability...
  7. Injectable Anabolic Biomaterials for Bone Regeneration
    LAKSHMI SREEDHARAN NAIR; Fiscal Year: 2013
    ..The aim of the proposed study is to evaluate the efficacy of an injectable biomaterial based on lactoferrin as an artificial microenvironment to increase the survival and osteogenic activity of encapsulated rat ..
  8. Female Genital Innate Immune Response to Vaginal Microbiota
    Caroline M Mitchell; Fiscal Year: 2013
    ..of antimicrobial peptides(beta-defensins, cathelicidin, secretory leukocyte protease inhibitor[SLPI], lactoferrin);2) that some individuals are more vulnerable to colonization due to low baseline levels of those antimicrobial ..
  9. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..iron from a variety of host-specific sources, including from the iron-binding glycoproteins, transferrin and lactoferrin. Iron transport from these iron-binding proteins is accomplished by an integral, outer membrane transporter, ..
  10. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2012
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  11. Microbiomes and Inflammation in Chronic Fatigue Syndrome
    RUTH EMILY LEY; Fiscal Year: 2013
    ..The amount of lactoferrin in stool samples will be determined as a measure of inflammation and bacterial endotoxin as an indication of ..
  12. Lactoferrin for prevention of sepsis in infants
    Theresa J Ochoa; Fiscal Year: 2013
    ..We hypothesize that lactoferrin, an iron binding protein present in mammalian milk, is the major factor responsible for this effect due to its ..
  13. Epithelial PLUNC as a determinant of Airway Mucosal Antimicrobial Activity
    YUANPU PETER DI; Fiscal Year: 2012
    ..ducts and submucosal glands, sites that express high levels of other host defense proteins such as lysozyme and lactoferrin. PLUNC is abundant in airway fluid of normal individuals and our preliminary results demonstrate that it ..
  14. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
    ..b>Lactoferrin (LF), a multifunctional "moonlighting" glycoprotein, is also a potent anabolic effector of the skeleton...
  15. Metabolomic Analysis as a Tool to Understanding the Use of Novel Therapeutics in
    MARY CLOUD BOSWORTH AMMONS; Fiscal Year: 2013
    ..metabolic patterns and that the biofilms are especially sensitive to iron deprivation by the immune molecule lactoferrin, document that exposure to P...
  16. Clinical Research in HSV Infections
    Anna Wald; Fiscal Year: 2013
    ..mediators of inflammation, such as secretory leukocyte protease inhibitor, human neutrophil peptides 1-3 and lactoferrin,...
  17. Probiotics to Improve Outcomes of Clostridium difficile
    Nasia Safdar; Fiscal Year: 2013
    ..rhamnosus HN001, when compared with placebo, will reduce CDI recurrence, fecal lactoferrin levels, and quantity of C. difficile toxin while improving functional status...
  18. Role of C/EBPepsilon in myeloid differentiation
    Stephanie Halene; Fiscal Year: 2010
    ..The appearance of the secondary granule proteins (SGP) lactoferrin (LF), transcobalamin I (TCI), neutrophil collagenase (NC) and neutrophil gelatinase (NG) marks the commitment ..
  19. Randomonized controlled trial-lactoferrin prevention of diarrhea in children
    THOMAS GEORGE CLEARY; Fiscal Year: 2010
    ..The proposed study is meant to begin addressing this important gap by a clinical trial of lactoferrin supplementation in previously weaned children...
  20. Functions of Lactoferrin Polymorphisms in an Oral Infection
    Kabilan Velliyagounder; Fiscal Year: 2011
    ..We recently have identified two new polymorphisms of the lactoferrin (Lf) gene that are involved in LAP...
  21. Lactoferrin as an Adjuvant for Cellular Immunity
    Jeffrey K Actor; Fiscal Year: 2010
    ..Regarding AIM III: the Aim III to investigate the systemic effects of the recombinant human lactoferrin using pre-IND, repeat dose toxicology protocols in two species (rat and dog) will be eliminated from the study...
  22. Innate Resistance to Mucosal HSV Infection in Humans
    Christine M Posavad; Fiscal Year: 2010
    ..and proteins in the mucosal samples with a focus on defensins, secretory leukocyte protease inhibitor (SLPI), lactoferrin and lysozyme, mediators linked to defense against HSV infection...
  23. Lactoferrin for the prevention of antibiotic-associated diarrhea in adult
    Ning Huang; Fiscal Year: 2012
    ..in vitro and preliminary in vivo studies lead us to hypothesize that oral administration of recombinant human lactoferrin as a medical food might be able to prevent and reduce antibiotic associated diarrhea in adults...
  24. Human Lactoferrin in Acetaminophen Overdose-Induced Liver Failure
    Cynthia Ju; Fiscal Year: 2012
    ..In our preliminary study with milk- derived lactoferrin, we demonstrate that the lactoferrin has a profound hepato-protective effect in a murine model of AILI...
  25. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2002
    ..In Aim 2, we will examine the ability of microcolonies to resist lactoferrin protease activity, to evade macrophage phagocytosis, and to enhance persistence in the chinchilla otitis media ..
  26. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..1) vitamin content and protein digestibility; 2) key bioactive proteins (immunoglobulin A, lysozyme and lactoferrin); 3) antibacterial activity...
  27. ANTIMICROBIAL EFFECT OF PEROXIDASE IN LEUKOCYTES
    SEYMOUR KLEBANOFF; Fiscal Year: 1999
    ..The binding of the released iron by lactoferrin will be investigated since this iron-binding protein is present in neutrophil granules and may serve as a ..
  28. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..32D cl3 myeloid cells were developed expressing C/EBPa-ER or PU.1-ER. Activation of C/EBPa-ER increased MPO, lactoferrin, and G-CSF receptor mRNA expression and induced a neutrophilic morphology and a G1 cell cycle arrest...
  29. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    DESCRIPTION: We have recently discovered that human lactoferrin, a member of the lactotransferrin family of iron binding proteins, has proteolytic activity...
  30. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
    This feasibility study is based on our hypothesis that recombinant human lactoferrin [rhLF] can prevent or reduce severity of necrotizing enterocolitis [NEC]. NEC is mainly a disease of very low birth weight [VLBW] human infants...
  31. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ..the apoE isoforms will be explored using: neurons from LDL receptor knockout animals; competition studies with lactoferrin and the 39-kDa protein; and mutants of apoE (apoE2, apoE(Arg142 yieldsCys), apoE Leiden) with various degrees ..
  32. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
    ..We have identified a region within the human lactoferrin (LF) gene promoter which confers a silencing effect on the expression of reporter gene plasmids in LF non-..
  33. INFECTION IN ELBW INFANTS:PROTECTION WITH MOTHER'S MILK
    Nancy Rodriguez; Fiscal Year: 2005
    ..immunologic factors, such as secretory immunoglobulin A, are absorbed and excreted in the infant's urine; lactoferrin, with enhanced bacteriocidal properties, has been recaptured from feces...
  34. CRYSTALLOGRAPHIC STUDIES OF NEISSERIA FE BINDING PROTEIN
    Duncan McRee; Fiscal Year: 1999
    ..Increasing evidence indicates that FBP shares a common fold and Fe-binding mechanism with lactoferrin, transferrin and bacterial periplasmic binding proteins...
  35. Effect of Oral Lactoferrin on Head and Neck Carcinoma
    Jeffrey Wolf; Fiscal Year: 2006
    ..This pilot projects aims to evaluate the effect of oral human recombinant lactoferrin as a chemotherapeutic agent on squamous cell carcinoma of the head and neck...
  36. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..S-IgA, lactoferrin and lysozyme in breast milk are the major antimicrobial factors...
  37. Phase II Clinical Trial of Lactoferrin in Asthma
    Atul Varadhachary; Fiscal Year: 2005
    The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma...
  38. Iron acquisition systems in Neisseria gonorrhoeae
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
    ..Although mechanisms for utilization of host iron-binding proteins, including transferrin and lactoferrin, have been most thoroughly characterized, expression of these receptors is not required for growth of the ..
  39. METABOLIC DETERMINANTS OF HEMATOPOIETIC CELL DEVELOPMENT
    Daniel Wright; Fiscal Year: 1999
    ..1 and C/EBF, implicated in myeloid cell development, as well as myeloid specific genes (e.g., CD11b and lactoferrin)...
  40. CASE CONTROL/STUDY OF PARKINSONS DISEASE IN THE ELDERLY
    Richard Mayeux; Fiscal Year: 1999
    ..Iron accumulates in the substantia nigra in IPD and lactoferrin receptors are increased whereas ferritin concentrations are reduced...
  41. X RAY STRUCTURAL STUDIES OF LACTOFERRIN
    Edward Baker; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Lactoferrin is a prominent iron-binding protein from human milk, other secretions, and leukocytes and possesses a wide variety of established or proposed biological activities...
  42. INVESTIGATIONS OF THE BIOCHEMISTRY OF VANADIUM
    Alison Butler; Fiscal Year: 1992
    ..the naturally occurring V-bromoperoxidase and V substituted derivatives of transferrin, lactoferrin, ovotransferrin, carboxypeptidase A, carbonic anhydrase B, thermolysin, bleomycin, etc), and to examine the ..
  43. HOST DEFENSE FACTORS IN ORAL ECOLOGY
    JOEL RUDNEY; Fiscal Year: 1991
    Saliva contains a number of proteins which display antinicrobial activity in vitro. These include lysozyme (Lz), lactoferrin (Lf), salivary peroxidase (Spx), secretory immunoglobulin A (sIgA), the mucin glycoproteins (MG1 and MG2), and ..
  44. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1993
    ..Even with iron supplementation, PMN lactoferrin and myeloperoxidase (MPO) release inhibited OH generation...
  45. BACTERICIDAL ACTIVITY OF LACTOFERRIN ON ORAL FLORA
    Roland Arnold; Fiscal Year: 1993
    b>Lactoferrin (LF), a principal glycoprotein component of secretions that bathe mucosal surfaces and of the specific granules of neutrophils (PMN), is capable of high affinity coordinate binding of Fe3+ and CO3 2- It has been shown to have ..
  46. Adenovirus Modulation of Lacrimal Gland Function
    SARAH HAMM ALVAREZ; Fiscal Year: 2005
    ..acinar cells of the lacrimal gland is the production and release of a variety of proteins including hormones, lactoferrin and lysosomal hydrolases into tear fluid...
  47. Use of recombinant human lactoferrin for wounds by stimulating cell growth
    Ning Huang; Fiscal Year: 2006
    ..We propose to use lactoferrin (LF) as a novel wound healing agent based on its ability to promote cell growth and its antimicrobial ..
  48. SALIVA AND ANTICANDIDAL DEFENSE MECHANISMS IN HIV/AIDS
    Chih ko Yeh; Fiscal Year: 2000
    ..The concentration and functional activity of histatins, lysozyme and lactoferrin will be evaluated...
  49. IMMORTALIZATION OF HUMAN SALIVARY EPITHELIAL CELL LINESS
    Dharam Chopra; Fiscal Year: 1992
    ..e. amylase, lactoferrin, secretory component, lysozyme, and mucin secretion; and by detecting cell specific mRNAs...
  50. REGULATORY ROLES OF LACTOFERRIN IN HEMOSTASIS
    Haifeng Wu; Fiscal Year: 2003
    b>Lactoferrin is a prominent component of neutrophil secondary granules and can be released when neutrophils are activated. The concentration of lactoferrin in blood has been demonstrated to be increased in certain inflammatory diseases...
  51. Expression of Human Transferrin in Rice Grain
    Deshui Zhang; Fiscal Year: 2009
    ..Ventria Bioscience already has produced the human lactoferrin, a close relative to human transferrin, in rice grains on large scale and at low lost...
  52. NATURE OF INHIBITORS OF HIV IN HUMAN SECRETORY FLUIDS
    JOSEPH KINKADE; Fiscal Year: 1992
    ..saliva, parotid saliva, and submandibular/sublingual saliva) and of a number of purified secretory components (lactoferrin, IgA, lactoferrin-IgA complexes, lysozyme, peroxidase, agglutinins and secretory leukocyte protease inhibitor) ..
  53. Treatment of Sepsis using Recombinant Human Lactoferrin
    Karel Petrak; Fiscal Year: 2006
    ..b>Lactoferrin has been shown to provide protection in several models of sepsis...
  54. LACTOFERRIN AND MUCOSAL IMMUNITY
    Larry Thomas; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): The important role of lactoferrin in innate mucosal immunity is well described...
  55. NEUTROPHIL INTERACTIONS WITH BACTEROIDES GINGIVALIS
    Christopher Cutler; Fiscal Year: 1991
    ..gingivalis by neurtophils will be determined and may involve myeloperoxidase (MPO), lactoferrin (LF), H202, hydroxy radical, singlet oxygen and superoxide production, and may occur intracellularly and ..
  56. FACTORS ASSOCIATED WITH DRY EYE IN POSTMENOPAUSAL WOMEN
    Kelly Nichols; Fiscal Year: 2003
    ..the relations between the additional diagnostic tests performed in the dry eye examination (osmolality, lactoferrin concentration, phenol red thread test, and lissamine green conjunctival staining) and our proposed definition ..
  57. Effects of Tobacco Smoke on Airway Bactericidal Activity
    Yuan Pu Di; Fiscal Year: 2004
    ..is specifically expressed in serous cells of submucosal glands where bactericidal proteins such as lysozyme and lactoferrin are secreted...
  58. MYCOBACTERIUM AVIUM--MECHANISMS OF IRON ACQUISITION
    RANDALL LAMBRECHT; Fiscal Year: 1992
    ..The hypothesis is that host iron-binding proteins, transferrin and lactoferrin, may facilitate iron delivery to intracellular MAC...
  59. PATHOPHYSIOLOGY OF THE LACTOFERRINS
    PHILIP FURMANSKI; Fiscal Year: 1999
    DESCRIPTION: (adapted from the investigator's abstract) Lactoferrin (Lf) is the most avid Fe-binding protein in human milk and other epithelial secretions and is the major constituent of the specific granules of neutrophils...
  60. PREVENTION/TREATMENT OF H. PYLORI WITH LACTOFERRIN
    BRUCE SCHRODER; Fiscal Year: 2001
    ..pylori). Preliminary research has found that bovine lactoferrin, a native antibiotic in bovine milk, is inhibitory to the growth of H...
  61. Lactoferrin as an Adjuvant for Cellular Immunity
    Jeffrey Actor; Fiscal Year: 2002
    ..We will specifically address the efficacy of Lactoferrin as an adjuvant to augment efficacy of BCG vaccination to subsequent challenge with virulent Mycobacterium ..
  62. Structure of Surface Antigens of S. Pneumoniae
    Debasish Chattopadhyay; Fiscal Year: 2005
    ..PspA inhibits killing of pneumococci by lactoferrin by binding to it...
  63. Regulation of gp91phox by Anaplasma phagocytophila
    Venetta Thomas; Fiscal Year: 2007
    ..In addition, transcription of lactoferrin, a second CDP regulated gene, is also down-regulated...
  64. DIAGNOSIS OF INFLAMMATORY DIARRHEA
    ROBERT CARMAN; Fiscal Year: 1992
    ..The following project will evaluate assays designed to detect lactoferrin released from leukocytes in fecal specimens from patients with inflammatory diarrhea...
  65. Lactoferrin in Primate and Mouse Models of Asthma
    Atul Varadhachary; Fiscal Year: 2004
    ..purpose of this research is to extend work to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in an established primate model of asthma...
  66. ANALYSIS OF M CATARRHLIS RECEPTORS AS VACCINE ANTIGENS
    ANTHONY CAMPAGNARI; Fiscal Year: 2003
    ..We have reported studies demonstrating that M. catarrhalis can obtain iron from human transferrin and lactoferrin for in vitro growth, an the absence of any detectable siderophore specific proteins on the bacterial surface...