granulocyte macrophage colony stimulating factor

Summary

Summary: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

Top Publications

  1. ncbi High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 64:6337-43. 2004
  2. ncbi An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    M B Lutz
    Department of Dermatology, University of Erlangen, Germany
    J Immunol Methods 223:77-92. 1999
  3. pmc Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
    E Stanley
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Victoria, Australia
    Proc Natl Acad Sci U S A 91:5592-6. 1994
  4. ncbi GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    Y Shibata
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunity 15:557-67. 2001
  5. pmc Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages from sheep naturally infected with maedi-visna virus and stimulates maedi-visna virus replication in macrophages in vitro
    Z Zhang
    Department of Veterinary Pathology, University of Edinburgh, Edinburgh, UK
    Clin Exp Immunol 129:240-6. 2002
  6. ncbi Pulmonary alveolar proteinosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2527-39. 2003
  7. ncbi Toll-like receptors stimulate human neutrophil function
    Fumitaka Hayashi
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, USA
    Blood 102:2660-9. 2003
  8. ncbi Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
    G Dranoff
    Whitehead Institute for Biomedical Research, Cambridge, MA
    Science 264:713-6. 1994
  9. pmc The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 195:953-8. 2002
  10. ncbi GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
    Eugene D Ponomarev
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    J Immunol 178:39-48. 2007

Detail Information

Publications307 found, 100 shown here

  1. ncbi High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 64:6337-43. 2004
    ....
  2. ncbi An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    M B Lutz
    Department of Dermatology, University of Erlangen, Germany
    J Immunol Methods 223:77-92. 1999
    ..This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations. It will be valuable to study DC biology notably at the molecular level...
  3. pmc Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
    E Stanley
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Victoria, Australia
    Proc Natl Acad Sci U S A 91:5592-6. 1994
    ..However, they implicate GM-CSF as essential for normal pulmonary physiology and resistance to local infection...
  4. ncbi GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    Y Shibata
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunity 15:557-67. 2001
    ..We conclude that PU.1 mediates GM-CSF-dependent effects on terminal differentiation of AMs regulating innate immune functions and surfactant catabolism by AMs...
  5. pmc Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages from sheep naturally infected with maedi-visna virus and stimulates maedi-visna virus replication in macrophages in vitro
    Z Zhang
    Department of Veterinary Pathology, University of Edinburgh, Edinburgh, UK
    Clin Exp Immunol 129:240-6. 2002
    ..1-100 ng/ml after 7 days. Viral mRNA expression was also enhanced. These findings indicate a role for GM-CSF in the pathogenesis of lymphoid interstitial pneumonia in infected animals...
  6. ncbi Pulmonary alveolar proteinosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2527-39. 2003
  7. ncbi Toll-like receptors stimulate human neutrophil function
    Fumitaka Hayashi
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, USA
    Blood 102:2660-9. 2003
    ..Finally, using quantitative polymerase chain reaction (QPCR), we demonstrate a chemokine expression profile that suggests that TLR-stimulated neutrophils recruit innate, but not acquired, immune cells to sites of infection...
  8. ncbi Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
    G Dranoff
    Whitehead Institute for Biomedical Research, Cambridge, MA
    Science 264:713-6. 1994
    ..These results demonstrate that GM-CSF is not an essential growth factor for basal hematopoiesis and reveal an unexpected, critical role for GM-CSF in pulmonary homeostasis...
  9. pmc The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 195:953-8. 2002
    ..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture...
  10. ncbi GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
    Eugene D Ponomarev
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    J Immunol 178:39-48. 2007
    ..These data also demonstrate that GM-CSF is a critical Th1 cell-derived cytokine required for the initiation of CNS inflammation associated with EAE, and likely MS...
  11. pmc Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties
    C P Carrasco
    Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
    Immunology 104:175-84. 2001
    ....
  12. ncbi Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice
    Amir Haghighat
    Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circulation 115:2049-54. 2007
    ..However, it is not known whether the short-term administration of G-CSF or GM-CSF exerts beneficial effects on atherosclerosis...
  13. ncbi Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF
    Dan H Barouch
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 168:562-8. 2002
    ..These results demonstrate that bicistronic DNA vaccines containing GM-CSF elicit remarkably potent CD4(+) T cell responses and suggest that optimal Th cell priming requires the precise temporal and spatial codelivery of Ag and GM-CSF...
  14. pmc Impaired differentiation of osteoclasts in TREM-2-deficient individuals
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 198:645-51. 2003
    ..These results demonstrate a critical role for TREM-2 in the differentiation of mononuclear myeloid precursors into functional multinucleated OCs...
  15. pmc Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice
    J A Huffman
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 97:649-55. 1996
    ..From these findings, we conclude that GM-CSF regulates the clearance or catabolism rather than synthesis of surfactant proteins and lipids...
  16. ncbi GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function
    I R Buschmann
    Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology and Angiology, Albert Ludwigs University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany
    Atherosclerosis 159:343-56. 2001
    ..In conclusion we have discovered a new function of the hemopoietic stem cell factor GM-CSF, which is also a powerful arteriogenic peptide that acts via prolongation of the life cycle of monocytes/macrophages...
  17. ncbi Regulation of myeloid development and function by colony stimulating factors
    Daniel R Barreda
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Dev Comp Immunol 28:509-54. 2004
    ..Although most of available knowledge about CSFs is on human and mouse CSFs, an attempt was made to integrate recent findings in other systems in order to highlight a more widespread role for CSFs throughout evolution...
  18. ncbi Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 64:775-802. 2002
    ..Together, these observations demonstrate that GM-CSF has a critical role in regulation of surfactant homeostasis and alveolar macrophage innate immune functions in the lung...
  19. ncbi Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures
    K Brasel
    Departments of Immunobiology and Discovery Research, Immunex Corporation, Seattle, WA 98101, USA
    Blood 96:3029-39. 2000
    ..Stem cell factor, which exhibits some of the same bioactivities as FL, was unable to replace FL to promote DC development in vitro. This culture system will facilitate detailed analysis of murine DC development...
  20. ncbi A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
    Wolf Rüdiger Schäbitz
    Department of Neurology, University of Munster, Munster, Germany
    J Cereb Blood Flow Metab 28:29-43. 2008
    ..Clinically, GM-CSF now broadens the repertoire of hematopoietic factors available as novel drug candidates for stroke and neurodegenerative diseases...
  21. pmc Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells
    F Geissmann
    Service d Anatomie Pathologique, Hopital Necker Enfants Malades, Paris, France
    J Exp Med 187:961-6. 1998
    ..e., the monocyte, in response to a TGF-beta1-rich microenvironment, as found in the skin and epithelia. Therefore, the monocyte may represent a circulating precursor critical to the immune response in vivo...
  22. ncbi The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
    Guido Hansen
    Biota Structural Biology Laboratory, St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Cell 134:496-507. 2008
    ..This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their mechanism of activation and for the development of therapeutics...
  23. ncbi Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover
    P J Blackshear
    Office of Clinical Research and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Soc Trans 30:945-52. 2002
    ..Together, the TTP family members should be capable of complex regulation of short-lived mRNAs containing this type of AU-rich instability motif...
  24. ncbi Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
    Madeleine M Hipp
    Department of Hematology, Oncology and Immunology, University of Tubingen, Tubingen, Germany
    Blood 111:5610-20. 2008
    ..These results indicate that sunitinib, but not sorafenib, is suitable for combination with immunotherapeutic approaches for treatment of cancer patients...
  25. pmc Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis
    J L McQualter
    Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Victoria 3086, Australia
    J Exp Med 194:873-82. 2001
    ..These results hold implications for the pathogenesis of inflammatory and demyelinating diseases and may provide the basis for more effective therapies for inflammatory diseases, and more specifically for multiple sclerosis...
  26. ncbi Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    Steven Bozinovski
    Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Chem 277:42808-14. 2002
    ..Inhibition of GM-CSF may be of therapeutic benefit in inflammatory diseases in which LPS contributes to lung damage...
  27. pmc Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
    A D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Res 3:293-8. 2001
    ..The results also highlight the essential role of GM-CSF in the ongoing development of inflammation and arthritis in CIA, with possible therapeutic implications for rheumatoid arthritis...
  28. pmc A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes
    Sarion R Bowers
    Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 29:1682-93. 2009
    ..We suggest that one important role of these sites is to enable the independent regulation of the IL-3 and GM-CSF genes...
  29. ncbi Cytokine responses induced by Toxoplasma gondii in astrocytes and microglial cells
    H G Fischer
    Institut für Medizinische Mikrobiologie und Virologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Eur J Immunol 27:1539-48. 1997
    ..gondii-induced pathway of astroglia activation characterized by the release of IL-1 which may drive local inflammatory reaction both at initial infection of the brain and during reactivating toxoplasmosis...
  30. ncbi Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Science Applications International Corp Frederick Cancer Research and Develeopment Center, National Cancer Institute, MD 21702, USA
    J Immunol 163:1737-41. 1999
    ....
  31. ncbi Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
    M P Hayes
    Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 86:646-50. 1995
    ..The selectivity of priming by IFN-gamma is in accord with a putative role for IL-12 in the initiation and amplification of TH1-type responses...
  32. pmc Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family
    Deborah J Stumpo
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 24:6445-55. 2004
    ..We postulate that lack of Zfp36L1 expression during mid-gestation results in the abnormal stabilization of one or more mRNAs whose encoded proteins lead directly or indirectly to abnormal placentation and fetal death...
  33. ncbi Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses
    Paul F McKay
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215, USA
    Eur J Immunol 34:1011-20. 2004
    ..Moreover, these studies show that different subsets of professional APC can selectively modulate DNA vaccine-elicited T lymphocyte responses...
  34. ncbi Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function
    George Miller
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 169:2875-85. 2002
    ..Our findings show that GM-CSF can have an important role in DC development and recruitment in vivo and has potential application to immunotherapy in recruiting massive numbers of DC with enhanced ability to activate effector cells...
  35. ncbi Dysfunctional and short-lived subsets in monocyte-derived dendritic cells from patients with advanced cancer
    Hideya Onishi
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Clin Immunol 105:286-95. 2002
    ..These results indicate that pMo-DCs contain dysfunctional and short-lived Mo-DC subsets...
  36. ncbi Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer
    John Nemunaitis
    US Oncology, Dallas, TX, USA
    J Natl Cancer Inst 96:326-31. 2004
    ..028), suggesting a vaccine dose-related survival advantage...
  37. ncbi Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease
    Sarah V Culpitt
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 167:24-31. 2003
    ..We conclude that the lack of efficacy of corticosteroids in COPD might be due to the relative steroid insensitivity of macrophages in the respiratory tract...
  38. ncbi GM-CSF priming of human monocytes is dependent on ERK1/2 activation
    Sven Lendemans
    Department of Trauma Surgery, University Hospital of Essen, Essen, Germany
    J Endotoxin Res 12:10-20. 2006
    ..It is concluded that a tyrosine kinase of the GM-CSF-triggered ERK1/2 pathway augments the LPS-induced NF-kappaB and AP-1 activation...
  39. pmc Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells
    A Saada
    Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Biol 133:159-67. 1996
    ..Our findings highlight the fact that fibroblasts, by producing GM-CSF and thereby affecting macrophage and Schwann function, play a significant role in the cascade of molecular events and cellular interactions of Wallerian degeneration...
  40. pmc Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils
    Andrew Filer
    MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Arthritis Rheum 54:2096-108. 2006
    ....
  41. ncbi GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung
    Pierre Yves Berclaz
    Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 100:4193-200. 2002
    ..1, regulates constitutive AM FcgammaR expression and opsonophagocytosis and is required for the IFN-gamma-dependent regulation of AM FcgammaR expression, enabling AMs to release IL-18/IL-12 during lung infection...
  42. ncbi Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:2264-73. 2002
    ..This function of GM-CSF is distinct from its primary function in cell proliferation and survival...
  43. ncbi Quantitative analysis of melanoma-induced cytokine-mediated immunosuppression in melanoma sentinel nodes
    Jonathan H Lee
    John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 11:107-12. 2005
    ..The goals of this study are to evaluate the role of melanoma in SN immunosuppression and to assess reversibility of SN immunosuppression by a cytokine therapy...
  44. ncbi Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes
    Pierre Shephard
    Department of Dermatology, University of Cologne, Germany
    Thromb Haemost 92:262-74. 2004
    ..Our results dissect the roles of TGF-beta and ET-1 on mechanical force generation in keratinocyte-fibroblast co-cultures, and identify GM-CSF as an inducer of myofibroblasts acting indirectly...
  45. pmc Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 92:9565-9. 1995
    ..The data establish that beta C is normally limiting for high-affinity binding of GM-CSF and demonstrate that systemic clearance of GM-CSF is not mediated via such high-affinity receptor complexes...
  46. ncbi IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages
    S I Hashimoto
    Department of Immunology, National Institutes of Health, Tokyo, Japan
    J Immunol 167:3619-25. 2001
    ..These results taken together with our previous results indicate that IL-10 plays a pivotal role in monocyte survival and development into macrophages in concert with M-CSF and GM-CSF...
  47. ncbi Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF
    Margarita Martinez-Moczygemba
    Biology of Inflammation Center, Departments of Medicine and Immunology, Baylor College of Medicine, Houston, TX, USA
    J Allergy Clin Immunol 112:653-65; quiz 666. 2003
    ..Delineating the biology of these cytokines is enabling the development of new strategies for diagnosing and treating these diseases and modulating immune responses...
  48. ncbi Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
    E Carballo
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Blood 95:1891-9. 2000
    ..TTP appears to be a physiological regulator of GM-CSF mRNA deadenylation and stability. (Blood. 2000;95:1891-1899)..
  49. ncbi Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: need for multiparametric evaluation due to adsorption artifacts
    Stéphanie Val
    University Paris Diderot Paris 7, Unit of Functional and Adaptive Biology BFA EAC CNRS 7059, Laboratory of Molecular and Cellular Responses to Xenobiotics, Paris, France
    Inhal Toxicol 21:115-22. 2009
    ..Thus, this study demonstrated the pro-inflammatory potential for CB and TiO(2) NP but underlines the methodological artifacts faced during the in vitro evaluation of cytokine release that necessitates a multiparametric evaluation...
  50. pmc Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis
    Jian Rong Sheng
    Department of Neurology and Rehabilitation, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Clin Immunol 128:172-80. 2008
    ..These observations suggest that the mobilization of antigen-specific Tregs in vivo using pharmacologic agents, like GM-CSF, can modulate ongoing anti-AChR immune responses capable of suppressing antibody-mediated autoimmunity...
  51. ncbi Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice
    R Paine
    Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1210-8. 2001
    ..Thus, in the absence of GM-CSF, AM functional capabilities for host defense were significantly impaired but were restored by lung-specific expression of GM-CSF...
  52. ncbi Brain dendritic cells and macrophages/microglia in central nervous system inflammation
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Duesseldorf, Germany
    J Immunol 166:2717-26. 2001
    ..These DC functionally mature upon disease onset and can differentiate from resident microglia. Their emergence, maturation, and prolonged activity within the brain might contribute to the chronicity of intracerebral Th1 responses...
  53. pmc Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch
    Mark A Guthridge
    Cytokine Receptor Laboratory, Department of Human Immunology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, SA, Australia
    EMBO J 25:479-89. 2006
    ..We have identified similar Tyr/Ser motifs in other cell surface receptors, suggesting that such signalling switches may play important roles in generating specificity and pleiotropy in other biological systems...
  54. ncbi C/EBPbeta is required for 'emergency' granulopoiesis
    Hideyo Hirai
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 7:732-9. 2006
    ..C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors...
  55. ncbi Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2
    E Y Lin
    Biology Graduate Group, School of Arts and Sciences, University of Pennsylvania, Philadelphia 19104
    J Immunol 151:1979-88. 1993
    ..These data demonstrate that A1 is a novel early-response gene whose expression is associated with a variety of stimuli and occurs in several hemopoietic cell types...
  56. ncbi Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions
    R Nishinakamura
    DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    Blood 88:2458-64. 1996
    ..Thus, there must be an alternative mechanism to produce blood cells in both situations...
  57. ncbi Bifurcation of osteoclasts and dendritic cells from common progenitors
    T Miyamoto
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Honjo, Japan
    Blood 98:2544-54. 2001
    ..The lineage determination of osteoclast progenitors seen following GM-CSF treatment functions through the regulation of c-Fos expression...
  58. ncbi Distinct changes in pulmonary surfactant homeostasis in common beta-chain- and GM-CSF-deficient mice
    J A Reed
    Children s Hospital Medical Center, Cincinnati, Ohio 43229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 278:L1164-71. 2000
    ..surfactant metabolism; alveolar macrophage; granulocyte-macrophage colony-stimulating factor..
  59. ncbi Phase I trial of combined immunotherapy with subcutaneous granulocyte macrophage colony-stimulating factor, low-dose interleukin 2, and interferon alpha in progressive metastatic melanoma and renal cell carcinoma
    G C de Gast
    Division of Medical Oncology, Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute, Amsterdam
    Clin Cancer Res 6:1267-72. 2000
    ..The scheme resulted in considerable expansion and/or activation of various effector cells. The complete responses in RCC patients are promising but need to be confirmed in Phase II studies...
  60. ncbi Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs
    Wi S Lai
    Office of Clinical Research and the Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 277:9606-13. 2002
    ..These data suggest that TTP may act, at least in part, by physically interacting with an enzyme activity or protein complex and functionally stimulating its ability to deadenylate class II ARE-containing mRNAs...
  61. pmc Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis
    H W Murray
    Division of Infectious Diseases, Cornell University Medical College, New York 10021
    J Clin Invest 95:1183-92. 1995
    ..These results identify a role for endogenous GM-CSF in the initial host defense response to L. donovani, reemphasize the influxing monocyte as an effector cell, and indicate that GM-CSF can be used as an antileishmanial treatment...
  62. ncbi Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family
    R P de Groot
    Department of Pulmonary Diseases, University Hospital Utrecht, The Netherlands
    Cell Signal 10:619-28. 1998
    ....
  63. pmc GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells
    F Seydel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Autoimmun 31:377-84. 2008
    ....
  64. ncbi Irradiation enhances the support of haemopoietic cell transmigration, proliferation and differentiation by endothelial cells
    M H Gaugler
    Institut de Protection et de Surete Nucleaire, Département de Protection de la santé de l Homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine, IPSN, Fontenay aux Roses, France
    Br J Haematol 113:940-50. 2001
    ..Together, these results suggest that, despite the radiation-induced damage, irradiated ECs may favour haemopoietic reconstitution after radiation exposure...
  65. ncbi Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    Ravi Salgia
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02215, USA
    J Clin Oncol 21:624-30. 2003
    ..To test whether this vaccination strategy enhances antitumor immunity in patients with metastatic non-small-cell lung cancer (NSCLC), we conducted a phase I clinical trial...
  66. pmc Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor
    K Hayashida
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 87:9655-9. 1990
    ..We therefore propose to designate the low-affinity GM-CSF receptor and the KH97 protein as the alpha and beta subunits of the GM-CSF receptor, respectively...
  67. pmc T cell functions in granulocyte/macrophage colony-stimulating factor deficient mice
    H Wada
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:12557-61. 1997
    ..Supernatants from both DC sources contained a factor or factors that restored proliferative responses and IFN-gamma production of CD4(+) T cells from GM-CSF -/- mice...
  68. ncbi CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma
    Anthony D Sandler
    Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52246, USA
    Cancer Res 63:394-9. 2003
    ..This vaccine strategy elicits a potent tumor antigen-specific immune response against established murine neuroblastoma and generates systemic neuroblastoma-specific immunity...
  69. ncbi IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes
    S A Litherland
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA
    J Autoimmun 22:227-33. 2004
    ..e., DR, IL1beta, TNFalpha, IL12, CD54, and CD64) remained intact. These findings suggest that the inability of IL10 to properly downregulate PGS2 gene expression may contribute to its dysregulation in Type 1 diabetes...
  70. ncbi Administration of IFN-alpha enhances the efficacy of a granulocyte macrophage colony stimulating factor-secreting tumor cell vaccine
    Rodney A Prell
    Department of Preclinical Oncology and Immunology, Cell Genesys, Inc, South San Francisco, CA 94080, USA
    Cancer Res 65:2449-56. 2005
    ..These data show that IFN-alpha combined with a granulocyte macrophage colony-stimulating factor-secreting tumor cell vaccine significantly enhances vaccine potency and may represent a potential new approach for tumor immunotherapy...
  71. ncbi Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor
    M R Walter
    Department of Pathology, University of Alabama, Birmingham 35294
    J Mol Biol 224:1075-85. 1992
    ..Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus...
  72. ncbi Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced monocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activity
    I Komuro
    Department of Immunology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    J Biol Chem 276:24360-4. 2001
    ....
  73. ncbi Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 376:167-70. 1995
    ..These results indicate that RelA controls inducible, but not basal, transcription in NF-kappa B-regulated pathways...
  74. ncbi Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages
    Kiyoko S Akagawa
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    Int J Hematol 76:27-34. 2002
    ..The characteristics of GM-Mphi resemble those of human alveolar macrophages...
  75. ncbi Recombinant GM-CSF plus autologous tumor cells as a vaccine for patients with mesothelioma
    Alex Powell
    School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Perth, Western Australia
    Lung Cancer 52:189-97. 2006
    ..We therefore evaluated the effect of an autologous MM tumor cell lysate, given s.c. with recombinant granulocyte-macrophage colony stimulating factor (GM-CSF), on anti-tumor immunity in patients with MM...
  76. ncbi Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Blood 100:1860-8. 2002
    ..Thus, our studies demonstrate that GM-CSF dramatically enhances the functional response of neutrophils to TLR2 ligands, including LPS-associated lipopeptides...
  77. ncbi The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production
    Claude Henry Volmar
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 42:336-44. 2008
    ..GM-CSF signaling may be a suitable therapeutic target against Abeta production in AD...
  78. ncbi Profile of cerebrospinal fluid and serum cytokines in patients with relapsing-remitting multiple sclerosis: a correlation with clinical activity
    P B Carrieri
    Department of Neurological Sciences, University of Naples Federico II, Italy
    Immunopharmacol Immunotoxicol 20:373-82. 1998
    ..These results suggest that a different cytokine pattern could be probably involved in the pathogenesis of relapsing-remitting MS...
  79. ncbi Enhanced expression of the receptor for granulocyte macrophage colony stimulating factor on dermal fibroblasts from scleroderma patients
    Loredana Postiglione
    Dip di Biologia e Patologia Molecolare e Cellulare, Università degli Studi Federico, Napoli, Italia
    J Rheumatol 29:94-101. 2002
    ..To elucidate events that initiate the involvement and stimulation of fibroblasts in systemic sclerosis (SSc)...
  80. ncbi Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors
    Marc Dauer
    Division of Clinical Pharmacology and Section of Gastroenterology, Medizinische Klinik Innenstadt, University of Munich, Munich, Germany
    J Immunol 170:4069-76. 2003
    ..Generation of FastDC not only reduces labor, cost, and time required for in vitro DC development, but may also represent a model more closely resembling DC differentiation from monocytes in vivo...
  81. pmc Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation
    Dan Laheru
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21231, USA
    Clin Cancer Res 14:1455-63. 2008
    ....
  82. ncbi Therapeutic induction of arteriogenesis in hypoperfused rat brain via granulocyte-macrophage colony-stimulating factor
    Ivo R Buschmann
    Albert Ludwigs University, Research Group for Experimental and Clinical Arteriogenesis, Department for Cardiology and Angiology, Breisacher Strasse 66, Freiburg im Breisgau, Germany
    Circulation 108:610-5. 2003
    ..Thus far, angiogenesis studies have failed to demonstrate improvement of stroke outcome. Arteriogenesis differs from angiogenesis in that it substitutes arterial collaterals for the occluded artery...
  83. ncbi Effect of GM-CSF on HIV-1 replication in monocytes/macrophages in vivo and in vitro: a review
    K Kedzierska
    Macfarlane Burnet Centre for Medical Research, Victoria, Australia
    Vet Immunol Immunopathol 63:111-21. 1998
    ..The possible mechanism by which GM-CSF might affect HIV-1 replication in macrophages remains unclear...
  84. ncbi Granulocyte macrophage colony stimulating factor (GM-CSF) activity is regulated by a GM-CSF binding molecule in Wallerian degeneration following injury to peripheral nerve axons
    Roni Mirski
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, P O B 12272, Jerusalem 91120, Israel
    J Neuroimmunol 140:88-96. 2003
    ..GM-CSF activity is thus regulated during Wallerian degeneration (WD); augmenter activity characterizes the onset and inhibitor activity the later stages of WD...
  85. ncbi Antitumor effects of combined granulocyte macrophage colony stimulating factor and macrophage inflammatory protein-3 alpha plasmid DNA
    Yun Choi
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Cancer Sci 101:2341-50. 2010
    ..the chemokine macrophage inflammatory protein-3 alpha (pMIP3α) and plasmid encoding the granulocyte macrophage colony stimulating factor (pGM-CSF; a DC-specific growth factor) can recruit, expand and activate large numbers of DC ..
  86. ncbi Bone marrow and splenic granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta mRNA levels in irradiated mice
    C M Chang
    Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Blood 86:2130-6. 1995
    ..These data suggest that radiation injury to hemopoietic tissues results in differential effects on GM-CSF and TGF-beta mRNA levels and that, in the case of GM-CSF, increased mRNA levels are not matched by increased protein production...
  87. pmc The combined effect of erythropoietin and granulocyte macrophage colony stimulating factor on liver regeneration after major hepatectomy in rats
    Ioannis Vassiliou
    Experimental Surgical Unit, 2nd Department of Surgery, Medical School, University of Athens, Aretaieion Hospital, Athens 11528, Greece
    World J Surg Oncol 8:57. 2010
    ..Aim of this experimental study is to compare the impact of exogenous administration of EPO, GM-CSF, as well as their combination on the promotion of liver regeneration after major hepatectomy...
  88. ncbi Granulocyte macrophage colony stimulating factor (GM-CSF) induced sero-protection in end stage renal failure patients to hepatitis B in vaccine non-responders
    R Jha
    Department of Nephrology, Medwin Hospitals, Hyderabad, Andhra Pradesh, India
    Ren Fail 23:629-36. 2001
    ..At one year, 24 out of 32 (75%) who were sero-protected earlier continued to remain sero-protected. This study indicates that GM-CSF is a potent HB vaccine adjuvant for sero-conversion in primary non-responders...
  89. ncbi Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability
    N Romani
    Department of Dermatology, University of Innsbruck, Austria
    J Immunol Methods 196:137-51. 1996
    ..Yields can be enhanced up to six-fold if the blood donors are pretreated with G-CSF. Stable, mature dendritic cells generated by this method should be a powerful tool for active immunotherapy...
  90. ncbi Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF
    J H Kim
    Department of Pharmacology and MRCCMT, Dong A University Medical College, Busan 604 714, South Korea
    Mol Ther 14:361-70. 2006
    ..JX-594 holds promise as an i.v.-delivered, targeted virotherapeutic. These two tumor models hold promise for the optimization of this approach...
  91. pmc Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
    Yoshikazu Inoue
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 754 Ichibannchoh, Asahimachi Tohri, Niigata 951 8520, Japan
    Am J Respir Crit Care Med 177:752-62. 2008
    ..Because PAP is rare, prior reports were based on limited patient numbers or a synthesis of historical data...
  92. pmc Developmental plasticity of CNS microglia
    L Santambrogio
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:6295-300. 2001
    ....
  93. ncbi Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients
    G Parmiani
    Unit of Immunotherapy of Human Tumors, Department of Innovative Therapies, Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 18:226-32. 2007
    ..The potential mechanisms of the GM-CSF-mediated immune suppression are discussed at the light of studies describing the activation and expansion of myeloid suppressor cells by endogenous tumor-derived or exogenous GM-CSF...
  94. ncbi Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Nature 407:383-6. 2000
    ..We conclude that cytokine signalling can regulate cell-fate decisions and propose that a critical step in lymphoid commitment is downregulation of cytokine receptors that drive myeloid cell development...
  95. ncbi Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation
    M Kagoshima
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 429:327-34. 2001
    ..These data suggest that the mechanism of glucocorticoid action in suppressing interleukin-1 beta-stimulated GM-CSF release in A549 cells may involve modulation of CBP-mediated histone-acetylase activity and DNA methylation...
  96. pmc Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice
    G Tiegs
    Department of Biochemical Pharmacology, Faculty of Biology, University of Konstanz, Germany
    J Clin Invest 93:2616-22. 1994
    ..These findings suggest that GM-CSF represents an endogenous enhancer of LPS-induced organ injury, possibly by potentiating the release of proinflammatory cytokines such as TNF and IL-1...
  97. ncbi The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine, Madison, WI 53705, USA
    J Immunol 177:6999-7006. 2006
    ..Mechanistically, Pin1 mediated the association of the AU-rich element-binding protein, AUF1, with GM-CSF mRNA, which determined the rate of decay by the exosome...
  98. ncbi Pulmonary alveolar proteinosis associated with anti-GM-CSF antibodies in a child: successful treatment with inhaled GM-CSF
    April Price
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 41:367-70. 2006
  99. ncbi Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia
    Arthur E Frankel
    Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 8:1004-13. 2002
    ..We tested the safety and efficacy of a diphtheria fusion protein [diphtheria toxin (DT)388 granulocyte-macrophage colony-stimulating factor (GMCSF)] directed against the GMCSF receptor that is strongly expressed by leukemic blasts...
  100. pmc Interleukin-3 signals through multiple isoforms of Stat5
    M Azam
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 14:1402-11. 1995
    ..These studies indicate that the IL-3 family of ligands is able to activate multiple isoforms of the signal transducing protein Stat5...
  101. ncbi Gene array identification of osteoclast genes: differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor
    Christopher J Day
    School of Health Sciences, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia
    J Cell Biochem 91:303-15. 2004
    ....

Research Grants64

  1. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  2. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..abstract_text> ..
  3. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Our long-acting GM-CSF analog may prove useful for improving survival in people exposed to an otherwise lethal dose of radiation as a result of a radiological/nuclear disaster. ..
  4. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..Thus, they have the potential to provide new therapeutic approaches to restore alveolar epithelial integrity while limiting unintended adverse effects. ..
  5. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..infarction and ventricular remodeling, bone marrow production of EPCs will be stimulated with granulocyte macrophage colony stimulating factor (GMCSF)...
  6. Antibody cytokine fusion proteins against Cryptococcus neoformans
    DAVID OWEN BEENHOUWER; Fiscal Year: 2012
    ..The proposed studies have relevance beyond cryptococcal infection, since a significant long-term objective is to design antibody-cytokine fusion proteins for use in other types of infections. ..
  7. Free Radical Mechanism in Obesity Potentiation of Environmental Hepatotoxicity
    Saurabh Chatterjee; Fiscal Year: 2013
    ..In Aim 2, 1 shall examine how initial lipid peroxidation, interferon-gamma (IFN-y) and granulocyte macrophage colony stimulating factor (GMCSF) lead to activation of macrophages and contribute to the second wave of generation of ..
  8. Theiler?s virus as a potential cause of Vilyuisk encephalitis
    HOWARD LEE LIPTON; Fiscal Year: 2010
    ..The murine counterpart, Theiler's murine encephalomyelitis virus, provides a highly relevant experimental animal model for multiple sclerosis. ..
  9. Iron and Mitochondrial Genomics in Neuro-inflammation and HAND: A CHARTER Study
    Asha R Kallianpur; Fiscal Year: 2013
    ....
  10. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    ..In addition, public health could be affected through the investigation of an immune modulating agent for the purposes of improving immune function to decrease nosocomial infection risk. ..
  11. GM-CSF for Immunomodulation Following Trauma (GIFT) Trial
    Mark W Hall; Fiscal Year: 2013
    ..abstract_text> ..
  12. Prospective Cohort Study of Cryptococcosis
    PETER RICHARD WILLIAMSON; Fiscal Year: 2013
    ..including deficiencies in specific IgG subtypes and the presence of auto-antibodies to granulocyte macrophage colony stimulating factor (GM CSF)...
  13. A Proof of Concept Study Examining The Safety and Efficacy of Innate Immune Syste
    Ted T Ashburn; Fiscal Year: 2013
    ..abstract_text> ..
  14. Development of GM-CSF reporter and reporter/fate-reporter mice
    Bogoljub Ciric; Fiscal Year: 2013
    ..We will also use Gr/fr mice to answer important biological questions, which will demonstrate their capacity to facilitate advances that would not be feasible otherwise. ..
  15. The Contribution of Chronic Inflammation to Pulmonary Adenocarcinoma
    MICHAEL LAWRENCE DOUGAN; Fiscal Year: 2010
    ....
  16. Surgery and the Mechanisms of Lymph Node Metastases in Cutaneous Melanoma
    Richard Essner; Fiscal Year: 2011
    ....
  17. INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    MARTIN FREDERICK KAGNOFF; Fiscal Year: 2013
    ..The research projects are supported by four Cores: a Mouse Model Core, a Histopathology Core, an Imaging and Cell Sorting Core and an Administrative Core. ..
  18. Directed Evolution of Blood Brain Barrier-Traversing Granulocyte Colony-Stimulati
    PETER J HEINZELMAN; Fiscal Year: 2013
    ....
  19. Roles of GM-CSF in Energy and Glucose Regulation
    Randy J Seeley; Fiscal Year: 2010
    ..The aims presented here are an important step in unveiling the specific roles that GM-CSF plays in the normal regulation of body weight and its potential connection to the pathology of diabetes. ..
  20. Therapeutic vaccines for treatment of experimental autoimmune encephalomyelitis (
    Mark D Mannie; Fiscal Year: 2011
    ....
  21. Predictors of clinical outcome after therapeutic vaccination in follicular lympho
    Sattva S Neelapu; Fiscal Year: 2013
    ..The proposed studies are likely to have substantial impact on the development of the cancer vaccine field in general and lymphoma vaccines in particular. ..
  22. GM-CSF Regulation of Zinc in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..Killing of yeasts by stimulated macrophages is mediated by zinc starvation. We seek to determine how zinc depletion occurs so that these findings can offer new avenues for treatment of this fungus. ..
  23. Phase II study: Mobilization of progenitor cells in peripheral arterial disease
    Arshed A Quyyumi; Fiscal Year: 2010
    ..In a Phase I study, we investigated mobilization of reparative bone marrow cells using granulocyte macrophage colony stimulating factor (GM-CSF) in patients with ischemic claudication...
  24. Emory Alcohol and Lung Biology Center
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..abstract_text> ..
  25. Enhancing protective antibody responses for a GM-CSF adjuvanted HIV vaccine
    Sue fen Kwa; Fiscal Year: 2013
    ..We highly stress the importance of eliciting higher titers and durable protective Ab responses for HIV vaccines and that enhancing our DNAGM/MVAVLP vaccine is a critical step forward to achieving an effective HIV vaccine. ..
  26. Mechanisms of optic nerve stroke neuroprotection
    Steven L Bernstein; Fiscal Year: 2012
    ....
  27. Aberrant Monocytic Differentiation Induced by Gain-of-Function Shp2 Mutants
    Rebecca J Chan; Fiscal Year: 2010
    ..Experiments outlined in this proposal are directed at identifying the molecular mechanisms that enhance monocyte overproduction in order to delineate novel targets for therapeutic intervention in JMML. ..
  28. Spin Probes in Semipermeable Nanospheres: EPR spectroscopy & imaging of tumor pH
    VALERY KHRAMTSOV; Fiscal Year: 2009
    ....
  29. Adjuvant-containing chimeric virus-like particles as improved influenza vaccines
    FU SHI contact QUAN; Fiscal Year: 2010
    ..The goal of this project is the development of an engineered adjuvant-containing and improved influenza vaccine that will induce broadly cross-protective and long-lasting immunity. ..
  30. PI3K Signaling in Juvenile Myelomonocytic Leukemia
    CHARLES B GOODWIN; Fiscal Year: 2013
    ..abstract_text> ..
  31. Molecular and Cellular Mechanisms of Chronic Myelomonocytic Leukemia (CMML)
    Jing Zhang; Fiscal Year: 2013
    ....
  32. Negative Regulation of Osteoclastogenesis
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..We will characterize these inhibitory mechanisms to obtain knowledge that can be used to develop new approaches to suppress osteoclastogenesis and pathologic bone resorption by augmenting these mechanisms therapeutically. ..
  33. Causes and consequences of neutrophil dysfunction in early onset Crohn's disease
    Subra Kugathasan; Fiscal Year: 2013
    ..Collectively, our studies will have direct implications for novel therapeutic approaches designed to modulate this critical host defense pathway in patients who experience the worst outcomes with current approaches. ..
  34. Treatment of Cerebral Edema using Ventricular Therapy
    JIM STICE; Fiscal Year: 2013
    ..Completion of Phase II aims will make pivotal human studies of RVOT catheters possible. ..
  35. Interferons as adjuvants for tolerogenic vaccines
    Mark D Mannie; Fiscal Year: 2013
    ....
  36. GM-CSF-Induced Metal Sequestration and Histoplasma
    George S Deepe; Fiscal Year: 2013
    ..This application utilizes an interdisciplinary team to open an intriguing vista in antimicrobial effector research and phagocyte biology. ..
  37. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  38. C-FES PROTEIN-TYROSINE KINASE IN MYELOID DIFFERENTIATION
    Robert Glazer; Fiscal Year: 1993
    ..Cognizance of this regulatory process should aid in the design of differentiation- specific therapies for myeloid leukemias...
  39. Biomarkers of Cognitive Decline among Normal Individuals: the BIOCARD cohort
    Marilyn S Albert; Fiscal Year: 2013
    ..RELEVANCE: The aim of this study is to examine measures that might be helpful in identifying normal individuals at risk for progression to mild or moderate cognitive impairment. ..
  40. 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Stavros Manolagas; Fiscal Year: 1991
    ....
  41. GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLS
    ROBERT BRESSLER; Fiscal Year: 1993
    ..A greater understanding of these important aspects of mast cell biology will offer important insights into the pathophysiology of mast cell-related diseases...
  42. IN-VITRO AND IN-VIVO EFFECTS OF GM-CSF ON ADULT ANLL
    Camille Abboud; Fiscal Year: 1992
    ....
  43. Quercetin Treatment of Airway Inflammation
    MARC HERSHENSON; Fiscal Year: 2006
    ..This project examines the value of quercetin, a plant pigment, in preventing airway inflammation in mouse models of disease. This work may lead to new treatments for asthma, cystic fibrosis or chronic bronchitis. ..
  44. GM-CSF is required for macrophage surfactant catabolism
    Tracey Bonfield; Fiscal Year: 2006
    ..abstract_text> ..
  45. STRUCTURE/FUNCTION OF THE SOLUBLE GM-CSF RECEPTOR
    MARIBETH RAINES; Fiscal Year: 1999
    ..These studies may also set a precedent for utilizing sGMR-alpha as a therapeutic agent or a diagnostic indicator of disease. ..
  46. GM-CSF THERAPY FOR ALVEOLAR PROTEINOSIS
    Mary Jane Thomassen; Fiscal Year: 2003
    ..The applicants feel that these studies coupled with data from the GM-CSF clinical trial will provide novel insights into the basic mechanisms underlying human PAP. ..
  47. Differential regulation of kisspeptin, dynorphin, and NKB in the same neurons
    Robert Goodman; Fiscal Year: 2007
    ..Thus, these studies may provide information important for the development of better treatments of these pathological disruptions of reproductive function. [unreadable] [unreadable] [unreadable]..
  48. EOSINOPHIL APOPTOSIS IN ASTHMA
    Gerald Litwack; Fiscal Year: 2001
    ..Furthermore, manipulation of these pathways will be a key area for therapeutic intervention in asthma. ..
  49. ROLE OF T LYMPHOCYTE FACTORS IN HEMOPOIESIS 0
    Michael Prystowsky; Fiscal Year: 1992
    ..These studies will further our understanding of the role that T lymphocytes play in regulating hemopoiesis...
  50. Targeting protein synthesis in AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies will hopefully lead to the design of pivotal phase II and III clinical trials which will define the role of DT388IL3 in the management of AML. ..
  51. Diphtheria fusion protein therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies should lead to the design of pivotal phase II clinical trials to determine the role of this therapeutic in AML management. ..
  52. EFFECT OF PERTUSSIS TOXIN ON HEMOPOIESIS
    Peter Quesenberry; Fiscal Year: 1991
    ..These studies should enable us to elucidate the first step of hemopoietic growth factor activation on bone marrow cells and indicate which metabolic pathways will be appropriate for further investigation...
  53. USE OF ERYTHROPOIETIN--A SURVEY OF ASCO AND ASH
    Charles Bennett; Fiscal Year: 1999
    ..colony stimulating factors (CSFs) G-CSF and GM-CSF (granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor) apply directly to erythropoietin...
  54. GROWTH FACTOR-DEPENDENT NORMAL & LEUKEMIC CELL GROWTH
    Daniela Santoli; Fiscal Year: 1992
    ....
  55. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 1991
    ..to cytokines produced by immune cells (Interleukin 1 (IL-1), Interleukin 3 (IL-3), and granulocyte macrophage colony stimulating factor (GM-CSF))...
  56. Combination fusion toxin and cytarabine therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2002
    ..We anticipate these studies should provide the basis for the design and implementation of pivotal multi-institutional phase II and III trials of DTGM/cytarabine therapy for relapsed/refractory AML. ..
  57. VIRAL EXACERBATIONS OF ASTHMA
    Scherer Sanders; Fiscal Year: 2002
    ..These studies should provide new insights into the pathogenesis of viral exacerbations of asthma and may provide the basis for improved therapeutic interventions. ..
  58. GENETIC REGULATION OF 03-INDUCED INFLAMMATION
    W Foster; Fiscal Year: 2003
    ..abstract_text> ..
  59. Retinoids and Substances of Abuse in HIV-1 Infection
    Walter Royal; Fiscal Year: 2006
    ..These studies will broaden our understanding of the immune effects of retinoid compounds in individuals with HIV infection, and may lead to effective approaches to the treatment of the infection and its complications with vitamin A...
  60. REGULATION OF MACROPHAGE ACTIVITY: IN VITRO VS IN VIVO
    MARY THOMASSEN; Fiscal Year: 1993
    ..Ultimately such findings will provide a basis for the future design of more effective immunological approaches to cancer therapy...
  61. Enhancement of targeting HIV vaccine to dendritic cell
    Sang Moo Kang; Fiscal Year: 2004
    ..As a long-term objective, the efficacy of targeting VLPs to DCs will be tested in a non-human primate model for designing a more effective AIDS vaccine. ..
  62. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
  63. ACTIVE IMMUNOTHERAPY FOR GLIOBLASTOMA
    John Yu; Fiscal Year: 2004
    ..A phase II trial will be initiated in year 3 of the training grant based on the phase I studies. ..
  64. LONG-ACTING GM-CSF PROTEINS FOR TREATING NEUTROPENIA
    Daniel Doherty; Fiscal Year: 2002
    ..Additional potential benefits include improved drug efficacy and improved patient quality of life. ..