granulocyte colony stimulating factor

Summary

Summary: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

Top Publications

  1. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
  2. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
  3. ncbi G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
    Craig L Semerad
    Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 17:413-23. 2002
  4. ncbi Granulocyte colony-stimulating factor and its receptor
    G D Demetri
    Department of Medicine, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 78:2791-808. 1991
  5. ncbi Regulation of myeloid development and function by colony stimulating factors
    Daniel R Barreda
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Dev Comp Immunol 28:509-54. 2004
  6. pmc Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial
    Woei Cherng Shyu
    Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan
    CMAJ 174:927-33. 2006
  7. ncbi The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
    Neal Flomenberg
    Thomas Jefferson University, 125 S Ninth St, Ste 801 Sheridan Bldg, Philadelphia, PA 19107, USA
    Blood 106:1867-74. 2005
  8. pmc Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    D Orlic
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:10344-9. 2001
  9. ncbi Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry
    David C Dale
    Department of Medicine, Box 356422, University of Washington, Seattle, WA 98195, USA
    Am J Hematol 72:82-93. 2003
  10. pmc Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    D E Zhang
    Department of Medicine, Beth Israel Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 94:569-74. 1997

Detail Information

Publications340 found, 100 shown here

  1. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  2. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  3. ncbi G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
    Craig L Semerad
    Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 17:413-23. 2002
    ..Evidence is provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone marrow may represent such a signal...
  4. ncbi Granulocyte colony-stimulating factor and its receptor
    G D Demetri
    Department of Medicine, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 78:2791-808. 1991
  5. ncbi Regulation of myeloid development and function by colony stimulating factors
    Daniel R Barreda
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Dev Comp Immunol 28:509-54. 2004
    ..Although most of available knowledge about CSFs is on human and mouse CSFs, an attempt was made to integrate recent findings in other systems in order to highlight a more widespread role for CSFs throughout evolution...
  6. pmc Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial
    Woei Cherng Shyu
    Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan
    CMAJ 174:927-33. 2006
    ..We sought to examine the feasibility, safety and efficacy of using G-CSF to treat acute stroke...
  7. ncbi The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
    Neal Flomenberg
    Thomas Jefferson University, 125 S Ninth St, Ste 801 Sheridan Bldg, Philadelphia, PA 19107, USA
    Blood 106:1867-74. 2005
    ..All study objectives were met without significant toxicity. The results demonstrate that the combination of A + G is generally safe, effective, and superior to G alone for autologous HPC mobilization...
  8. pmc Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    D Orlic
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:10344-9. 2001
    ..In conclusion, mobilization of primitive BMC by cytokines might offer a noninvasive therapeutic strategy for the regeneration of the myocardium lost as a result of ischemic heart disease and, perhaps, other forms of cardiac pathology...
  9. ncbi Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry
    David C Dale
    Department of Medicine, Box 356422, University of Washington, Seattle, WA 98195, USA
    Am J Hematol 72:82-93. 2003
    ..The risk of leukemia, osteoporosis, other potentially adverse events, and pregnancy outcome need to be further evaluated with continuing long-term observations...
  10. pmc Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    D E Zhang
    Department of Medicine, Beth Israel Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 94:569-74. 1997
    ..In addition, the c/ebp alpha -/- mice may be useful in understanding the mechanisms involved in acute myelogenous leukemia, in which a block in differentiation of myeloid precursors is a key feature of the disease...
  11. ncbi Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    Christopher Lock
    Department of Neurology and Neurological Sciences, Beckman Center, Stanford University, Stanford, California, USA
    Nat Med 8:500-8. 2002
    ..These results in EAE corroborate the microarray studies on MS lesions. Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy...
  12. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...
  13. ncbi Human granulocyte colony stimulating factor (hG-CSF) expressed by methylotrophic yeast pichia pastoris
    M A Lasnik
    LEK dd, R and D, Ljubljana, Slovenia
    Pflugers Arch 442:R184-6. 2001
    Human granulocyte colony stimulating factor (hG-CSF) was expressed in the methylotrophic yeast Pichia pastoris, using two different constructs which resulted in proteins with different N-terminal sequences...
  14. ncbi The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
    I K Campbell
    Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 68:144-50. 2000
    ..Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA...
  15. pmc Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    J Clin Invest 111:187-96. 2003
    ....
  16. ncbi Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis
    P Schwarzenberger
    Gene Therapy Program and Departments of Medicine, Pediatrics, and Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Immunol 164:4783-9. 2000
    ..IL-17 is a cytokine that potentially interconnects lymphocytic and myeloid host defense and may have potential for therapeutic development...
  17. ncbi Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin's lymphoma
    C H Moskowitz
    Lymphoma and Hematology Services, Department of Medicine, and Departments of Radiotherapy, Pathology, and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 17:3776-85. 1999
    ....
  18. ncbi Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis
    Yuanjin Zhang
    Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Beijing, China
    Amyotroph Lateral Scler 10:430-1. 2009
    We investigated the safety and efficacy of the granulocyte colony stimulating factor (G-CSF) in 13 patients with amyotrophic lateral sclerosis (ALS)...
  19. ncbi Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia
    Jens Minnerup
    Universitatsklinikum Munster, Klinik und Poliklinik fur Neurologie, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Stroke 39:1855-61. 2008
    ..To guide further development, a meta-analysis was performed to assess the effects of G-CSF on infarct size and sensorimotor deficits...
  20. ncbi A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells
    L B To
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 84:2930-9. 1994
    ..0001). These observations are novel and suggest that different mobilization protocols may act via similar pathways involving the down-regulation of c-kit and may be independent of cell-cycle status...
  21. pmc Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin
    T Papayannopoulou
    Department of Medicine, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 90:9374-8. 1993
    ..These data provide insight on the involvement of VLA4 antigens in the in vivo trafficking of progenitors and are of relevance to collection of peripheral blood stem cells for transplantation...
  22. pmc The combination of granulocyte colony-stimulating factor and stem cell factor significantly increases the number of bone marrow-derived endothelial cells in brains of mice following cerebral ischemia
    Zsuzsanna E Toth
    National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Blood 111:5544-52. 2008
    ..These findings suggest that G-CSF/SCF treatment might help recovery through induction of bone marrow-derived angiogenesis, thus improving neuronal survival and functional outcome...
  23. ncbi Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation
    Uddalak Bharadwaj
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 67:5479-88. 2007
    ....
  24. pmc Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Exp Med 201:1307-18. 2005
    ..These results support the hypothesis that the CXCL12-CXCR4 axis is involved in marrow retention of HSCs and HPCs, and demonstrate the clinical potential of AMD3100 for HSC mobilization...
  25. ncbi Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia
    Jean Paul Duong Van Huyen
    University Paris Descartes, Paris, France
    Mod Pathol 21:837-46. 2008
    ....
  26. ncbi Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    F Dong
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    N Engl J Med 333:487-93. 1995
    ..Abnormalities in the signal-transduction pathways for granulocyte colony-stimulating factor (G-CSF) may play a part in the progression to acute myeloid leukemia...
  27. ncbi The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand
    F Liu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110 1093, USA
    Blood 90:2522-8. 1997
    ..These results show that the G-CSFR is required for mobilization in response to cyclophosphamide or IL-8 but not flt-3 ligand and suggest that the G-CSFR may play an important and previously unexpected role in HPC migration...
  28. ncbi Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 189:1506-15. 2004
    ..During pneumococcal pneumonia, G-CSF is produced locally at the site of the infection, where it exerts both pro- and anti-inflammatory effects...
  29. ncbi Rabbit antithymocyte globulin (r-ATG) plus cyclosporine and granulocyte colony stimulating factor is an effective treatment for aplastic anaemia patients unresponsive to a first course of intensive immunosuppressive therapy. Gruppo Italiano Trapianto di M
    E Di Bona
    Haematology Department, San Bortolo Hospital, Vicenza, Italy
    Br J Haematol 107:330-4. 1999
    ..age 21 years, range 2-67) not responding to a first course with h-ALG plus cyclosporin (CyA) and granulocyte colony stimulating factor (G-CSF), were given a second course using r-ATG (3...
  30. ncbi C/EBPbeta is required for 'emergency' granulopoiesis
    Hideyo Hirai
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 7:732-9. 2006
    ..C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors...
  31. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
    ..Furthermore, the central role of this chemokine in stem cell homing to the bone marrow as well as retention of undifferentiated cells within this tissue will also be discussed...
  32. ncbi Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate
    Heather G Jørgensen
    Section of Experimental Haematology, Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Queen Elizabeth Building, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Clin Cancer Res 12:626-33. 2006
    ....
  33. pmc Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors
    Jovencio Borneo
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 35:1026-37. 2007
    ..The intracellular signals that contribute to granulocyte colony-stimulating factor (G-CSF) receptor induced stem cell mobilization are poorly characterized...
  34. ncbi Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization
    K Watari
    Department of Hematology Oncology, University of Tokyo, Japan
    Stem Cells 12:416-23. 1994
    Production of human granulocyte colony stimulating factor (G-CSF) by stromal cells was studied in vitro...
  35. ncbi Granulocyte colony stimulating factor/macrophage colony stimulating factor improves postinfarct ventricular function by suppression of border zone remodelling in rats
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Clin Exp Pharmacol Physiol 31:873-82. 2004
    1. The aim of the present study was to examine the effects of mobilization of bone marrow cells by granulocyte colony stimulating factor (G-CSF) and macrophage colony stimulating factor (M-CSF) on ventricular function after myocardial ..
  36. ncbi Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes
    T Horan
    Amgen Inc, Amgen Center, Thousands Oaks, California 91320 1789, USA
    Biochemistry 35:4886-96. 1996
    ..This is consistent with the idea that G-CSF binding alters the conformation of the receptor, resulting in an increase in receptor-receptor interactions...
  37. pmc CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation
    Christophe Cataisson
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    J Clin Invest 116:2757-66. 2006
    ..Thus, skin can be the source of circulating factors that have both local and systemic consequences, and these factors, their receptors, and possibly PKCalpha could be therapeutic targets for inhibition of cutaneous inflammation...
  38. ncbi Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease
    Jo L Eyles
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Clin Pract Rheumatol 2:500-10. 2006
    ..These findings implicate G-CSF as an important proinflammatory cytokine. This article discusses the roles of neutrophils and G-CSF during chronic inflammatory diseases...
  39. pmc Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis
    Craig H Mermel
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, Saint Louis, MO 63110, USA
    Blood 108:2562-8. 2006
    ..Together, these data establish Lyn and Hck as key negative regulators of granulopoiesis and raise the possibility that loss of Src family kinase activation by the d715 G-CSFR may contribute to its hyperproliferative phenotype...
  40. ncbi Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
    Woei Cherng Shyu
    Department of Neurology, Neuro Medical Scientific Center, Tzu Chi Buddhist General Hospital, Tzu Chi University, Hualien, Taiwan
    Circulation 110:1847-54. 2004
    ..Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists...
  41. ncbi IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines
    P Schwarzenberger
    Department of Medicine, Louisiana State University Medical Center, New Orleans 70112, USA
    J Immunol 161:6383-9. 1998
    ..Since IL-17 is principally produced by CD4+ T cells, this cytokine could have therapeutic implications in AIDS-related bone marrow failure and opportunistic infections...
  42. pmc An extended window of opportunity for G-CSF treatment in cerebral ischemia
    Armin Schneider
    Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Biol 4:36. 2006
    ..In addition to these trophic effects, G-CSF is a potent neuroprotective factor reliably reducing infarct size in different stroke models...
  43. ncbi Bladder tumor producing granulocyte colony-stimulating factor and parathyroid hormone related protein
    Kiyoshi Hirasawa
    Department of Urology, Tokyo University Hospital and Toranomon Hospital, Tokyo, Japan
    J Urol 167:2130. 2002
  44. ncbi Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor
    John Thomas
    Washington University School of Medicine, Division of Oncology, Section of Stem Cell Biology, St Louis, Missouri 63110 1093, USA
    Curr Opin Hematol 9:183-9. 2002
    ..This review summarizes these advances, emphasizing the mechanisms regulating granulocyte colony-stimulating factor-induced mobilization...
  45. ncbi Anaplastic thyroid carcinoma associated with granulocyte colony-stimulating factor: report of a case
    Takeo Fujita
    Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Surg Today 36:63-7. 2006
    ..As a result, her general condition deteriorated rapidly and the patient died 2 weeks after the onset of leukocytosis...
  46. ncbi Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum
    J Witowski
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Kidney Int 71:514-25. 2007
    ..These data demonstrate that the mesothelium-derived G-CSF plays an important role in IL-17A-induced PMN recruitment into the peritoneum...
  47. pmc Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model
    Lauri Burroughs
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 106:4002-8. 2005
    ..In summary, both autologous and allogeneic AMD3100-mobilized PBMCs led to prompt and durable engraftment in dogs after 920 cGy TBI...
  48. ncbi Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Immunol 175:2606-12. 2005
    ..These results suggest that the PGE2-EP2 system contributes to the local production of G-CSF during acute inflammation...
  49. ncbi Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case
    Tetsuo Ikeda
    Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan
    Surg Today 35:590-3. 2005
    ..An immunohistochemical examination using polyclonal antibody against G-CSF was performed to stain the tumor cells, which confirmed the diagnosis of a G-CSF-producing tumor...
  50. ncbi Progenitor-cell mobilization after low-dose cyclophosphamide and granulocyte colony-stimulating factor: an analysis of progenitor-cell quantity and quality and factors predicting for these parameters in 101 pretreated patients with malignant lymphoma
    M J Watts
    Department of Haematology, University College London Medical School, United Kingdom
    J Clin Oncol 15:535-46. 1997
    ....
  51. pmc Functional domains of the granulocyte colony-stimulating factor receptor
    R Fukunaga
    Osaka Bioscience Institute, Japan
    EMBO J 10:2855-65. 1991
    ..The CRH domain and a portion of the cytoplasmic domain of about 100 amino acids in length were indispensable for transduction of the G-CSF-triggered growth signal...
  52. pmc Granulocyte colony-stimulating factor receptor expression on human transitional cell carcinoma of the bladder
    M Tachibana
    Department of Urology, School of Medicine, Keio University, Tokyo, Japan
    Br J Cancer 75:1489-96. 1997
    ..1%) presented positive G-CSFR mRNA signals. Thus, in this study, G-CSFR expression was frequently observed on bladder cancer cells. Therefore, the clinical use of G-CSF for patients with bladder cancer should be selected with great care...
  53. ncbi "Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection
    S Basu
    Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 95:3725-33. 2000
    ..Blood. 2000;95:3725-3733)..
  54. pmc G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Craig L Semerad
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
    Blood 106:3020-7. 2005
    ..The consequent attenuation of CXCR4 signaling ultimately leads to HPC mobilization...
  55. ncbi Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture
    Yutaka Mifune
    Stem Cell Translational Research, Institute of Biomedical Research and Innovation RIKEN Center for Developmental Biology, Kobe, Japan
    Stem Cells 26:1395-405. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  56. ncbi Interleukin-17 and lung host defense against Klebsiella pneumoniae infection
    P Ye
    Gene Therapy Program, Section of Pulmonary and Critical Care, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Respir Cell Mol Biol 25:335-40. 2001
    ..These data show that IL-17 may have a role in priming for enhanced chemokine and G-CSF production in the context of lung infection and that optimally timed gene therapy with IL-17 may augment host defense against bacterial pneumonia...
  57. ncbi Cytokines and hematopoietic stem cell mobilization
    Bruno Nervi
    Division of Oncology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Cell Biochem 99:690-705. 2006
    ..In addition we will describe food and drug administration (FDA) approved and agents currently in clinical development for enhancing HSC mobilization and transplantation outcomes...
  58. ncbi Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells
    M Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 18:1482-90. 2004
    ..In conclusion, a novel mechanism for HSC engraftment was identified, which involves complement activation and specific C3 fragments that promote conditioning for transplantation and enhance HSPC engraftment...
  59. ncbi SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    Immunity 20:153-65. 2004
    ..We conclude that SOCS3 is a key negative regulator of G-CSF signaling in myeloid cells and that this is of particular significance during G-CSF-driven emergency granulopoiesis...
  60. ncbi Granulocyte colony stimulating factor directly inhibits myocardial ischemia-reperfusion injury through Akt-endothelial NO synthase pathway
    Kazutaka Ueda
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Japan
    Arterioscler Thromb Vasc Biol 26:e108-13. 2006
    b>Granulocyte colony stimulating factor (G-CSF) has been reported recently to prevent cardiac remodeling and dysfunction after acute myocardial infarction through signal transducer and activator of transcription 3 (STAT3)...
  61. ncbi Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy
    Dawn Hershman
    Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Natl Cancer Inst 99:196-205. 2007
    ..Although these growth factors support chemotherapy, their long-term safety has not been evaluated. We studied the association between G-CSF use and incidence of leukemia in a population-based sample of breast cancer patients...
  62. ncbi Complete remission induced by high dose erythropoietin and granulocyte colony stimulating factor in acute erythroleukemia (AML-M6 with maturation)
    Andrea Camera
    Haematologica 87:1225-7. 2002
    ....
  63. ncbi Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease
    Yongzhong Wang
    Cardiac Catheterization Laboratory, The Heart Centre, Rigshospitalet, Copenhagen, Denmark
    Int J Cardiol 100:477-83. 2005
    A phase I safety and efficacy study with granulocyte colony stimulating factor (G-CSF) mobilization of bone marrow stem cells to induce vasculogenesis in patients with severe ischemic heart disease (IHD) was conducted...
  64. ncbi Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization
    Masashi Ohtsuka
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    FASEB J 18:851-3. 2004
    ..Even if the cytokine treatment is started after MI, it could prevent LV remodeling and dysfunction after MI--at least in part--through an increase in neovascularization and a decrease in apoptosis in the border area...
  65. ncbi Phase I study of cladribine, cytarabine (Ara-C), granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating doses of imatinib mesylate (Gleevec) in relapsed/refractory AML
    Alison R Walker
    James P Wilmot Cancer Center, University of Rochester, Rochester, NY, USA
    Leuk Res 32:1830-6. 2008
    ..To assess the efficacy of imatinib mesylate in combination with CLAG, a larger phase II trial is now planned...
  66. ncbi Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle
    D E Wright
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Blood 97:2278-85. 2001
    ..After CY/G-CSF treatment, virtually all BM LT-HSC enter the cell cycle; some of these HSC then migrate into the blood, specifically after M phase, and are rapidly recruited to particular hematopoietic organs...
  67. ncbi Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
    W Conrad Liles
    Department of Medicine, University of Washington, HSB AA 522, Box 356422, Seattle, WA 98195
    Blood 102:2728-30. 2003
    ..AMD3100 was well tolerated and caused only mild, transient toxicity. These findings suggest potential clinical application of AMD3100 for CD34+ cell mobilization and collection for hematopoietic stem cell transplantation...
  68. ncbi Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment
    Shinya Minatoguchi
    Second Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu, Japan
    Circulation 109:2572-80. 2004
    ....
  69. ncbi Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP
    A Bosly
    Department of Haematology, University Hospital of Mont Godinne, Yvoir, Belgium
    Ann Hematol 87:277-83. 2008
    ..002). Dose reductions and/or delays, mainly due to hematological toxicities, resulted in a reduction in treatment intensity. These data indicate that patient outcome is improved when the intensity of chemotherapy treatment is optimal...
  70. pmc The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation
    Antje M Wengner
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    Blood 111:42-9. 2008
    ..8 x 10(6) and 5.4 x 10(6) neutrophils, respectively, while the infusion of KC and G-CSF together mobilized 19.5 x 10(6) neutrophils, indicating that these factors act cooperatively with respect to neutrophil mobilization...
  71. pmc G-CSF rescues the memory impairment of animal models of Alzheimer's disease
    Kuen Jer Tsai
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan, Republic of China
    J Exp Med 204:1273-80. 2007
    ..We suggest that G-CSF, a drug already extensively used for treating chemotherapy-induced neutropenia, should be pursued as a novel, noninvasive therapeutic agent for the treatment of AD...
  72. ncbi AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 1106:1-19. 2007
    ..These results demonstrate the means to increase the mobilization of HPCs, the engrafting capability of HSCs, and responsiveness of HPCs to the survival-enhancing activity of SDF-1/CXCL12, effects that may be of practical value...
  73. ncbi Cytokine-mediated regulation of CXCR4 expression in human neutrophils
    Hiroyuki Nagase
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Japan
    J Leukoc Biol 71:711-7. 2002
    ..These results on PMNs support the argument that the SDF-1 (CXCL12)/CXCR4 system is regulated by cell type-specific mechanisms...
  74. pmc Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis
    Ping Jin
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 6:39. 2008
    ..The HSCs were compared to peripheral blood leukocytes (PBLs) from 7 subjects...
  75. ncbi Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulation
    Stefano Rossetti
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncogene 24:5325-32. 2005
    ..Thus, there seems to be an association between AML1-MTG16-induced myeloid maturation block and epigenetic changes of a myeloid master gene...
  76. ncbi Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells
    L M Souza
    Science 232:61-5. 1986
    ..The secreted form of the protein produced by the bladder carcinoma cell line 5637 was found to be O-glycosylated and to have a molecular weight of 19,600...
  77. pmc Stromal cell-derived factor-1 enhances pro-angiogenic effect of granulocyte-colony stimulating factor
    Yaohong Tan
    Department of Surgery, Vascular Biology Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Cardiovasc Res 73:823-32. 2007
    ..Stromal cell-derived factor-1 (SDF-1) enhances the homing of progenitor cells mobilized from the bone marrow and augments neovascularization in ischemic tissue. We hypothesize that SDF-1 will boost the pro-angiogenic effect of G-CSF...
  78. pmc Human progenitor cells rapidly mobilized by AMD3100 repopulate NOD/SCID mice with increased frequency in comparison to cells from the same donor mobilized by granulocyte colony stimulating factor
    David A Hess
    Department of Internal Medicine, Division of Oncology, Hematopoietic Development and Malignancy Group, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA
    Biol Blood Marrow Transplant 13:398-411. 2007
    ..Thus, AMD3100 mobilized peripheral blood represents a rapidly obtained, highly repopulating source of hematopoietic progenitors for clinical transplantation...
  79. ncbi Granulocyte colony-stimulating factor attenuates early ventricular expansion after experimental myocardial infarction
    Yasuo Sugano
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cardiovasc Res 65:446-56. 2005
    ..It is reported that granulocyte colony-stimulating factor (G-CSF) can accelerate wound healing. The aim of our study was to investigate the effect of G-CSF on early ventricular expansion after MI...
  80. ncbi G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases
    Anke Franzke
    Department of Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Blood 102:734-9. 2003
    ....
  81. ncbi G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient
    V Reddy
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Transplantation 69:691-3. 2000
    ..G-CSF treatment of bone marrow transplantation recipients, without pretreatment of the donor, does not have an impact on acute GVHD...
  82. ncbi Granulocyte colony-stimulating factor promotes the generation of regulatory DC through induction of IL-10 and IFN-alpha
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Rome, Italy
    Eur J Immunol 34:1291-302. 2004
    ..This novel mechanism of immune regulation effected by G-CSF might be therapeutically exploited for tolerance induction in autoimmune disorders...
  83. ncbi Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia
    M H Hermans
    Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 92:32-9. 1998
    ..These findings indicate that depending on G-CSF levels in mice, the triangle Delta715 mutation can contribute both to neutropenia and to neutrophilia...
  84. ncbi G-CSF protects dopaminergic neurons from 6-OHDA-induced toxicity via the ERK pathway
    Hsin Yi Huang
    Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Tzu Chi College of Technology, Hualien 970, Taiwan, ROC
    Neurobiol Aging 28:1258-69. 2007
    ..These results suggest that G-CSF might have a therapeutic potential in Parkinson's disease...
  85. ncbi Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells
    Hiroshi Kawada
    Division of Hematology, Department of Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Circulation 113:701-10. 2006
    ..We administered these hematopoietic cytokines after focal cerebral ischemia and assessed their effects and the therapeutic time window for neuronal regeneration...
  86. ncbi Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells
    Jean Pierre Levesque
    Stem Cell Laboratory, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, Victoria 3000, Australia
    Exp Hematol 31:109-17. 2003
    ..We sought to determine the mechanisms responsible for the reduced expression of c-KIT on mobilized hematopoietic progenitor cells...
  87. ncbi Phase III study of intensive weekly chemotherapy with recombinant human granulocyte colony-stimulating factor versus standard chemotherapy in extensive-disease small-cell lung cancer. The Japan Clinical Oncology Group
    K Furuse
    Department of Internal Medicine, National Kinki Central Hospital for Chest Diseases, Osaka, Japan
    J Clin Oncol 16:2126-32. 1998
    ....
  88. ncbi Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemok
    A G King
    Department of Molecular Virology and Host Defense, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426 0989, USA
    Blood 97:1534-42. 2001
    ....
  89. ncbi A novel role of complement in mobilization: immunodeficient mice are poor granulocyte-colony stimulating factor mobilizers because they lack complement-activating immunoglobulins
    Ryan Reca
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 25:3093-100. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  90. ncbi (18)F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors
    Miyako Morooka
    Division of Nuclear Medicine, Department of Radiology, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Ann Nucl Med 22:635-9. 2008
    Tumors producing granulocyte colony stimulating factor (G-CSF), malignant lung tumors in most cases, are rare, and patients present with abnormal elevations of the white blood cell (WBC) count in the absence of any infectious disease...
  91. ncbi Erythropoietin addition to granulocyte colony-stimulating factor abrogates life-threatening neutropenia and increases peripheral-blood progenitor-cell mobilization after epirubicin, paclitaxel, and cisplatin combination chemotherapy: results of a randomiz
    L Pierelli
    Cattedra di Ematologia, Istituto di Ostetricia e Ginecologia, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Clin Oncol 17:1288. 1999
    ....
  92. ncbi The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor
    A C Ward
    Institute of Hematology, Erasmus University Rotterdam, The
    Biochem Biophys Res Commun 251:117-23. 1998
    ..In addition, we show that Hck becomes activated upon G-CSF treatment and is, in turn, able to phosphorylate the G-CSF-R, indicating a clear functional and physical involvement in G-CSF signaling...
  93. ncbi Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow
    Janina Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, 529 South Jackson St, KY 40202, USA
    Blood 103:2071-8. 2004
    ..The C3a-C3aR axis may prevent an uncontrolled release of HSPCs into peripheral blood. These data further suggest that the C3aR antagonist SB 290157 could be developed as a drug to mobilize HSPCs for transplantation...
  94. pmc CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer
    M Fukuoka
    Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan
    Br J Cancer 75:306-9. 1997
    ..rhG-CSF administration in support of CODE chemotherapy resulted in increased mean total received dose intensity for all drugs (P = 0.03) with a significant improvement in survival (P = 0.004)...
  95. ncbi Prevention of chemotherapy-induced febrile neutropenia by prophylactic antibiotics plus or minus granulocyte colony-stimulating factor in small-cell lung cancer: a Dutch Randomized Phase III Study
    Johanna N Timmer-Bonte
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, The Netherlands
    J Clin Oncol 23:7974-84. 2005
    ..This multicenter randomized phase III trial determines whether the addition of G-CSF to antibiotic prophylaxis can further reduce the incidence of FN in patients with small-cell lung cancer (SCLC) at the risk of FN...
  96. ncbi Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS)
    Neil Cashman
    ALS Centre Brain Research Centre, University of British Columbia, Vancouver, BC, Canada
    Muscle Nerve 37:620-5. 2008
    ....
  97. ncbi G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, University of Nottingham, UK
    J Neuropathol Exp Neurol 64:763-9. 2005
    ..This suggests that part of the neuroprotection may be attributed to the ability of G-CSF to reduce the inflammatory response...
  98. ncbi G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
    Mutsuo Harada
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Nat Med 11:305-11. 2005
    ..These results suggest that G-CSF promotes survival of cardiac myocytes and prevents left ventricular remodeling after myocardial infarction through the functional communication between cardiomyocytes and noncardiomyocytes...
  99. pmc Impact of neutropenia on delivering planned adjuvant chemotherapy: UK audit of primary breast cancer patients
    R C F Leonard
    Cancer Institute Singleton Hospital, Swansea SA2 8QA, UK
    Br J Cancer 89:2062-8. 2003
    ..During adjuvant chemotherapy of primary breast cancer, neutropenic events are common, likely to occur in subsequent chemotherapy cycles, and have a significant impact on receiving planned DI...
  100. ncbi Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine
    Koji Iwanaga
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Biochem Biophys Res Commun 325:1353-9. 2004
    ..These findings suggest that G-CSF prevents cardiac dysfunction and remodeling after MI in large animals...
  101. ncbi Granulocyte colony-stimulating factor for the induction of T-cell tolerance
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A Gemelli 8, 00168 Rome, Italy
    Transplantation 84:S26-30. 2007
    ..The growing body of evidence supporting a novel role for G-CSF in the induction of T-cell tolerance is reviewed herein...

Research Grants63

  1. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..The drug should prove useful for treating other diseases for which G-CSF is used as a therapy, such as neutropenia resulting from chemotherapy use in cancer patients. ..
  2. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..Here, we will explore further the hypothesis that the retention of hematopoietic stem and progenitor cells in the niche is regulated by differing signals from the sympathetic nervous system and macrophages. ..
  3. TNF Alpha in PKC Epsilon Signaling to Carcinogenesis
    Ajit K Verma; Fiscal Year: 2013
    ..Specific Aim #3: To define the mechanism, using gene-silencing techniques, by which PKC5 signals UVR-induced TNF1 and G-CSF gene expression. ..
  4. Transferrin Conjugates for Oral Protein Drug Delivery
    Wei Chiang Shen; Fiscal Year: 2013
    ..Such a new generation of protein drugs for convenient effective oral delivery will overcome patient incompliance, high cost, and adverse side effects currently associated with injectable dosage forms. ..
  5. Long-Acting G-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Our long-acting G-CSF analog may prove useful for improving survival in people exposed to an otherwise lethal dose of radiation as a result of a radiological/nuclear disaster. ..
  6. Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
    Juan R Sanchez-Ramos; Fiscal Year: 2012
    Abstract/Summary Filgastrim (granulocyte colony stimulating factor or G-CSF) is a multi-modal hematopoietic growth factor used routinely in the hematology/oncology setting but reports of its benefits for brain diseases are appearing in ..
  7. Enhancing neutrophil function in neutropenia-related pneumonia
    Hongbo R Luo; Fiscal Year: 2012
    ..Lastly, PtdIns(3,4,5)P3 signaling can also be augmented by disrupting InsP3KB;and thus we will explore whether disruption of InsP3KB can also reduce the severity of neutropenia-related pneumonia (Aim IV). ..
  8. Hematopoietic Growth Factors and Chronic Stroke
    Li Ru Zhao; Fiscal Year: 2013
    ..Additionally, this knowledge may also lead to the development of new treatments for other neurological disorders and neurodegenerative diseases. ..
  9. Mechanisms of G-CSF-Induced Neuroprotection
    Jiping Tang; Fiscal Year: 2012
    ..Achieving our goal will lay the foundation for clinical evaluation of systemic administration of G-CSF in human neonates for prevention and treatment of brain damage from hypoxia/ischemia. ..
  10. Th17 Cytokines and Lung Immunity
    Jay K Kolls; Fiscal Year: 2013
    ..We have identified a novel T-cell population that plays a critical role in defense against pneumonia. This application will explore how these cells are generated and how they control host defense in the lung. ..
  11. Directed Evolution of Blood Brain Barrier-Traversing Granulocyte Colony-Stimulati
    PETER J HEINZELMAN; Fiscal Year: 2013
    ....
  12. ROLE OF THE G-CSF RECEPTOR IN PROGENITOR MOBILIZATION
    Daniel C Link; Fiscal Year: 2013
    ..Aim 2. We will define the contribution of Cxcl12 expression by osteoblasts and endothelial cells to HSC function and trafficking. ..
  13. Short Course G-CSF as Immunomodulatory Therapy for Type 1 Diabetes ? A Pilot Stud
    MICHAEL JAMES HALLER; Fiscal Year: 2010
    ..b>Granulocyte colony stimulating factor (G-CSF) has recently been shown to prevent T1D in the Non Obese Diabetic (NOD) mouse model of the ..
  14. HEPylated G-CSF: Drug with Safer, Enhanced Delivery for Neutropenia Treatment
    Wei Jing; Fiscal Year: 2011
    ..will focus on creating and testing HEPylated versions of a current drug, a long acting version of granulocyte colony stimulating factor (G-CSF) used in the treatment of neutropenia (abnormally low white blood cell counts)...
  15. Brain metabolism and neuroprotection in cardiopulmonary bypass
    Anna Pastuszko; Fiscal Year: 2012
    ....
  16. TARGETING AML-STROMAL INTERACTIONS
    John F DiPersio; Fiscal Year: 2013
    ..to target the CXCR4-SDF-1 axis using a small molecule bicyclam, AMD3100 in conjunction with Granulocyte Colony Stimulating Factor (G-CSF), to promote rapid and sustained release of AML blasts from the BM microenvironment in ..
  17. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2011
    ..Infection-induced production of granulocyte colony stimulating factor (G-CSF) and interleukin-8 (IL-8) will be investigated as upstream regulators of PMN mobilization ..
  18. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2013
    ..Infection-induced production of granulocyte colony stimulating factor (G-CSF) and interleukin-8 (IL-8) will be investigated as upstream regulators of PMN mobilization ..
  19. OPTIMIZING ALLOGENEIC TRANSPLANTATION USING CXCR4 BLOCKADE
    John F DiPersio; Fiscal Year: 2010
    ..b>Granulocyte Colony Stimulating Factor (G-CSF) with or without chemotherapy has become the standard of care for PBSC mobilization in the ..
  20. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
    ..Our hypothesis predicts that IL-17R signaling by lung parenchymal cells is required for production of G-CSF and optimal CXC chemokine production and subsequent neutrophil recruitment in response to experimental K. pneumoniae infection. ..
  21. Novel hematopoietic effects of C5 cleavage fragment
    Mariusz Z Ratajczak; Fiscal Year: 2013
    ..In particular, C5-deficient mice are poor mobilizers in response to granulocyte colony stimulating factor (G-CSF) and exhibit delayed hematopoietic reconstitution after transplantation with wild type (WT) ..
  22. Macrophage Regulation of the Hematopoietic Stem Cell Niche
    JONATHAN GEORGE HOGGATT; Fiscal Year: 2013
    ....
  23. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    ..Furthermore, we anticipate that with the appropriate subsequent research and clinical trials this research will have a positive impact on the survival of cord blood stem cell transplant patients. ..
  24. Improving hematopoietic stem cell mobilization by the EGFR inhibitor Erlotinib
    Hartmut Geiger; Fiscal Year: 2012
    ..In this project we will focus on developing inhibition of EGFR signaling by Erlotinib a a novel product to improve stem cell mobilization and the successful treatment of cancer patients. 1 ..
  25. The effect of niche-specific cxcl12 production on B lymphopoiesis.
    RYAN BRENT DAY; Fiscal Year: 2013
    ..Aim 1: Analyze the effect of CXCL12 deletion in osteolineage or endothelial cells on B lymphopoiesis. Aim 2: Analyze the role of niche-specific CXCL12 production on B cell bone marrow localization, proliferation, and survival. ..
  26. TrialNet: University of Florida Clinical Center and Network
    DESMOND ARTHUR SCHATZ; Fiscal Year: 2013
    ..mechanistic and safety) data using a combination of low-dose Anti-Thymocyte Globulin (ATG) and Granulocyte Colony Stimulating Factor (GCSF) in NOD mice, (ii) encouraging data in other human autoimmune disorders and transplantation (..
  27. Structural requirements for immunostimulation by plant lipids
    Akira Kawamura; Fiscal Year: 2013
    ..The proposed research, therefore, opens an exciting possibility that QOL of cancer patients can be improved with a cocktail of chemically defined, orally available small molecules. ..
  28. Severe Chronic Neutropenia International Registry
    DAVID CHANDLER DALE; Fiscal Year: 2013
    ..It is also used to further research to determine the causes of neutropenia. ..
  29. IN-VITRO AND IN-VIVO EFFECTS OF GM-CSF ON ADULT ANLL
    Camille Abboud; Fiscal Year: 1992
    ....
  30. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    ..During that period we have also identified mediators, prostaglandin E2 (PGE2) and granulocyte colony stimulating factor (G-CSF) that play a significant role in the myelopoietic alterations of burn injury...
  31. Molecular Studies of Severe Congenital Neutropenia
    Andrew Aprikyan; Fiscal Year: 2005
    ..These models will be useful for development of novel therapeutic strategies for treatment of severe congenital neutropenia and prevention of its evolution to acute myeloid leukemia. ..
  32. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2004
    ..Important examples of such cytokines emphasized within this proposal include: granulocyte colony stimulating factor (G-CSF), which stimulates production of neutrophils under basal and high-demand conditions; and ..
  33. Targeted Therapy of Lyn in Myelodysplastic Syndrome
    SETH JOEL COREY; Fiscal Year: 2010
    ..These studies will provide rationale for a phase II study using Src inhibitors for subsets of MDS patients. ..
  34. G-CSF Receptor and Ubiquitination
    Belinda Avalos; Fiscal Year: 2006
    ....
  35. JAK-3 AND MYELOID CELL DIFFERENTIATION
    E Reddy; Fiscal Year: 2000
    ..It is becoming increasingly evident that certain cytokines such as Granulocyte Colony Stimulating Factor (G-CSF) can transmit signals for both cellular proliferation and differentiation...
  36. Cytokine Signaling in Autoimmune APC Dysfunction
    Sally Litherland; Fiscal Year: 2005
    ..abstract_text> ..
  37. USE OF ERYTHROPOIETIN--A SURVEY OF ASCO AND ASH
    Charles Bennett; Fiscal Year: 1999
    ..identified previously for the hematopoietic colony stimulating factors (CSFs) G-CSF and GM-CSF (granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor) apply directly to erythropoietin...
  38. Allogeneic Stem Cell Transplants for HPV+Cervical Cancer
    Alexander Fefer; Fiscal Year: 2003
    ..The clinical and laboratory results are expected to provide a rational basis and direction for the design of subsequent trials of tumor-specific adoptive cellular immunotherapy in the context of this treatment regimen. ..
  39. Alcohol and Impairment of the Granulopoietic Response to Pneumonia
    Ping Zhang; Fiscal Year: 2010
    ..It may also identify potential therapeutic approaches for the effective treatment of pneumonia in these immunocompromised patients. ..
  40. G-CSF RECEPTOR ISOFORMS AND MYELOPOIESIS
    Scott White; Fiscal Year: 1999
    ..A better understanding of relative G-CSFR isoform expression will provide insight into a variety of disorders of myelopoiesis, such myelogenous leukemia or myelodysplastic syndromes. ..
  41. MECHANISMS OF MYELOID MATURATION ARREST IN BURN SEPSIS
    Ravi Shankar; Fiscal Year: 2000
    ....
  42. IN UTERO TRANSPLANTATION IN BETA-THALASSEMIC
    Ewa Carrier; Fiscal Year: 2001
    ..The candidate will have developed an independent research program involving in utero transplantation and have progressed to a more advanced phase of her academic career. ..
  43. A software tool for optimizing the solubility of therapeutic proteins.
    STEVEN WHITTEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. The Effect of G-CSFR Mutations on Granulopoiesis
    MORGAN MCLEMORE; Fiscal Year: 2006
    ..The role of STAT-3 in the transduction of G-CSF induced survival signals will be characterized. ..
  45. PATHOPHYSIOLOGY OF G-CSF IN NEUTROPENIA
    William Hammond; Fiscal Year: 1993
    ..Recent studies have shown that when dogs are treated with recombinant human granulocyte colony stimulating factor (rhG-CSF), they have a brief neutrophilia followed by a prolonged period of severe neutropenia...
  46. LONG ACTING G-CSF PROTEINS FOR TREATING NEUTROPENIA
    George Cox; Fiscal Year: 1999
    ..Additional potential benefits include improved drug efficacy and improved patient quality of life. ..
  47. Application of Expanded Myeloid Progenitors for Infection (Phase II)
    Ramkumar Mandalam; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  48. PACLITAXEL INDUCED PAINFUL PERIPHERAL NEUROPATHY IN RATS
    Rosemary Polomano; Fiscal Year: 2002
    ..abstract_text> ..
  49. TERMINAL DIFFERENTIATION AS A THERAPEUTIC APPROACH
    Alan Sartorelli; Fiscal Year: 2001
    ..abstract_text> ..
  50. LOSS OF NEGATIVE SIGNALING BY THE G-CSFR IN AML
    Belinda Avalos; Fiscal Year: 2002
    ....
  51. GROWTH FACTOR CONJUGATES FOR TREATING HORMONAL DISEASES
    George Cox; Fiscal Year: 2001
    ..We propose to create long-acting forms of growth hormone, granulocyte colony stimulating factor and erythropoietin by creating larger versions of these proteins with longer circulating half-..
  52. Genetic Reg. of Hematopoietic Stem Cell Mobilization
    Hartmut Geiger; Fiscal Year: 2007
    ..g. to muscle tissue, or to other hematopoietic niches. ..
  53. DEVELOPMENTAL MECHANISMS OF FETAL/NEONATAL CYTOPENIAS
    Robert Christensen; Fiscal Year: 1999
    ....
  54. Therapeutic Strategy for Recurrent Spontaneous Abortion
    Darryl Carter; Fiscal Year: 2005
    ..We hypothesize that recombinant human granulocyte colony stimulating factor (rhG-CSF) will prevent RSA caused by Th1 cytokine overproduction because rhG-CSF is known to cause ..
  55. Negative Regulation of Signal Transduction by G-CSF
    Fan Dong; Fiscal Year: 2006
    ..The proposed research will improve our understanding of the regulatory network of G-CSF signaling and the molecular mechanisms by which C- terminal truncation of the G-CSF receptor contribute to leukemogenesis. ..
  56. MOLECULAR REGULATION OF MYELIOD CELL DIFFERENTIATION
    Kathleen Sakamoto; Fiscal Year: 2000
    ..The myeloid leukemic cell lines, 32Dc13, differentiatesinto granulocyte but does not proliferate in the presence of G-CSF. TF-1, a human myeloid leukemic cell line, differentiates to macrophages in response to TPA. ..
  57. MIXED CRYSTAL GROWTH FOR BIOPHARMACEUTICAL STABILIZATION
    Bart Kahr; Fiscal Year: 1999
    ..The specific focus is to invent a simple method of room temperature storage of such protein drugs as granulocyte colony-stimulating factor and interferon in innocuous host crystals. ..
  58. CONFERENCE ON PROTEIN DELIVERY TO THE LUNGS
    John Patton; Fiscal Year: 1999
    ..e. growth hormone, insulin, interferon, granulocyte colony stimulating factor, etc.)...
  59. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  60. Chemokine induced hematopoietic stem cell mobilization
    LOUIS PELUS; Fiscal Year: 2009
    ....
  61. Acquisition of FACSVantage SE Flow Cytometer
    Yair Gazitt; Fiscal Year: 2004
    ..The new equipment will also widen the user's base, save sort time, reduce costs for users and will render sorting affordable to new users, especially in cases where low frequency (<1%) cell populations are sorted. ..
  62. MARROW REGULATION IN CYCLIC HEMATOPOIESIS
    David Dale; Fiscal Year: 2003
    ....
  63. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..