erythropoietin

Summary

Summary: Glycoprotein hormone, secreted chiefly by the kidney in the adult and the liver in the fetus, that acts on erythroid stem cells of the bone marrow to stimulate proliferation and differentiation.

Top Publications

  1. ncbi A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    Marc A Pfeffer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 361:2019-32. 2009
  2. ncbi Correction of anemia with epoetin alfa in chronic kidney disease
    Ajay K Singh
    Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 355:2085-98. 2006
  3. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
  4. ncbi Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  5. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
  6. ncbi Differential erythropoietin action upon cells induced to eryptosis by different agents
    Daiana M Vota
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN CONICET Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
    Cell Biochem Biophys 65:145-57. 2013
  7. pmc Regulation of erythropoietin production
    Wolfgang Jelkmann
    Institute of Physiology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Physiol 589:1251-8. 2011
  8. ncbi Erythropoietin, erythropoiesis and beyond
    S Chateauvieux
    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hopital Kirchberg, 9, rue Edward Steichen, L 2540 Luxembourg, Luxembourg
    Biochem Pharmacol 82:1291-303. 2011
  9. pmc Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, UK
    Diabetes 60:2995-3005. 2011
  10. ncbi Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells
    Angus M Sinclair
    Department of Hematology, Amgen Inc, Thousand Oaks, CA, USA
    Blood 115:4264-72. 2010

Research Grants

Detail Information

Publications340 found, 100 shown here

  1. ncbi A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    Marc A Pfeffer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 361:2019-32. 2009
    ..Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately tested...
  2. ncbi Correction of anemia with epoetin alfa in chronic kidney disease
    Ajay K Singh
    Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 355:2085-98. 2006
    Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency...
  3. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
    ..Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established...
  4. ncbi Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  5. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
    We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3'-flanking sequence which can mediate a sevenfold transcriptional induction in response to hypoxia when cloned 3' to a simian virus 40 promoter-..
  6. ncbi Differential erythropoietin action upon cells induced to eryptosis by different agents
    Daiana M Vota
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN CONICET Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
    Cell Biochem Biophys 65:145-57. 2013
    ..cell calcium overload) so as to distinguish whether they share signaling pathways and could be prevented by erythropoietin (Epo)...
  7. pmc Regulation of erythropoietin production
    Wolfgang Jelkmann
    Institute of Physiology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Physiol 589:1251-8. 2011
    The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival, proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly from fibroblasts in the renal cortex...
  8. ncbi Erythropoietin, erythropoiesis and beyond
    S Chateauvieux
    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hopital Kirchberg, 9, rue Edward Steichen, L 2540 Luxembourg, Luxembourg
    Biochem Pharmacol 82:1291-303. 2011
    b>Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was initially highlighted for its action on the hematopoietic system...
  9. pmc Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, UK
    Diabetes 60:2995-3005. 2011
    b>Erythropoietin (EPO) may be protective for early stage diabetic retinopathy, although there are concerns that it could exacerbate retinal angiogenesis and thrombosis...
  10. ncbi Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells
    Angus M Sinclair
    Department of Hematology, Amgen Inc, Thousand Oaks, CA, USA
    Blood 115:4264-72. 2010
    Erythropoiesis stimulating agents (ESAs) have been reported to activate erythropoietin receptors (EpoR) on cell types, including endothelial, neuronal, renal tubule, and cardiac cells. ESAs have also been reported to promote angiogenesis...
  11. ncbi A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery
    Peter T Tsai
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:1269-74. 2006
    b>Erythropoietin (EPO) is the principal growth factor regulating the production of red blood cells. Recent studies demonstrated that exogenous EPO acts as a neuroprotectant and regulates neurogenesis...
  12. ncbi Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation
    Sarah Millot
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Universite Paris Diderot, Paris, France
    Blood 116:6072-81. 2010
    ..of zymosan-induced generalized inflammation, which induces long-lasting anemia and to evaluate the ability of erythropoietin (Epo) injections to correct anemia in this setting...
  13. ncbi Erythropoietin: a hormone with multiple functions
    Matilde Lombardero
    Department of Anatomy and Animal Production, Faculty of Veterinary Sciences, University of Santiago de Compostela, Lugo, Spain
    Pathobiology 78:41-53. 2011
    b>Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as by the liver in fetal life, is implicated in mammalian erythropoiesis...
  14. pmc Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    A L Siren
    Max Planck Institute for Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 98:4044-9. 2001
    b>Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults by largely unknown mechanisms...
  15. ncbi Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurosci 26:5996-6003. 2006
    We investigated the hypothesis that endothelial cells activated by erythropoietin (EPO) promote the migration of neuroblasts...
  16. ncbi Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth
    Michael Taschwer
    Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria
    J Biotechnol 157:295-303. 2012
    ..and product quality, the same procedure was repeated with a recombinant CHO cell line producing an erythropoietin-Fc fusion protein (CHO-EpoFc) for this publication...
  17. ncbi Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants
    Juliana Parsons
    Plant Biotechnology, University of Freiburg, Freiburg, Germany
    Plant Biotechnol J 10:851-61. 2012
    ..wild-type proteins, but was shown to be enriched on complex-type N-glycans of moss-produced recombinant human erythropoietin, while unknown from the native human protein...
  18. pmc Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, New Jersey Health Sciences University, Newark, New Jersey 07101, USA
    Aging (Albany NY) 4:187-201. 2012
    ..We show that the cytokine erythropoietin (EPO) decreases the toxic effect of Aβ on microgliain vitro...
  19. pmc EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes
    Zhao Zhong Chong
    Department of Neurology and Neurosciences, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:103-20. 2011
    ..b>Erythropoietin (EPO) represents one of these novel strategies but the dependence of EPO upon Wnt1 and its downstream ..
  20. pmc Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia
    Yan Chen Shang
    Laboratory of Cellular and Molecular Signaling, University of Medicine and Dentistry, New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:270-85. 2011
    ..Here we demonstrate that erythropoietin (EPO), an emerging strategy for immune system modulation, prevents microglial early and late apoptotic injury ..
  21. ncbi Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling
    Nehmat Ghaboura
    Protection et remodelage du myocarde, UPRES EA 3860, Faculte de Medecine, Universite d Angers, Rue Haute de Reculee, 49045 Angers Cedex 1, France
    Basic Res Cardiol 106:147-62. 2011
    Recent studies reported cardioprotective effects of erythropoietin (EPO) against ischemia-reperfusion (I/R) injury through activation of the reperfusion injury salvage kinase (RISK) pathway...
  22. pmc Erythropoietin receptor response circuits
    Don M Wojchowski
    Center of Excellence in Stem Cell Biology and Regenerative Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA
    Curr Opin Hematol 17:169-76. 2010
    In 1985-1989, erythropoietin (EPO), its receptor (EPOR), and janus kinase 2 were cloned; established to be essential for definitive erythropoiesis; and initially intensely studied...
  23. ncbi Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
    Numerous preclinical findings and a clinical pilot study suggest that recombinant human erythropoietin (EPO) provides neuroprotection that may be beneficial for the treatment of patients with ischemic stroke...
  24. ncbi Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin
    N Byts
    Section of Experimental Neurosurgery, Department of Neurosurgery, University of Wurzburg, Josef Schneider St 11, 97080 Wurzburg, Germany
    Cell Death Differ 15:783-92. 2008
    ..activator of transcription 5a and 5b (Stat5) are activated by the neuroprotective and neurotrophic cytokines, erythropoietin (EPO) and growth hormone (GH)...
  25. pmc Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
    Michael Brines
    Warren Pharmaceuticals, Ossining, NY 10562, USA
    Proc Natl Acad Sci U S A 105:10925-30. 2008
    b>Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays a critical hormonal role regulating erythrocyte production as well as a paracrine/autocrine role in which locally produced EPO protects a wide variety of tissues ..
  26. ncbi Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial)
    Zoltan H Endre
    Christchurch Kidney Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand
    Kidney Int 77:1020-30. 2010
    We performed a double-blind placebo-controlled trial to study whether early treatment with erythropoietin could prevent the development of acute kidney injury in patients in two general intensive care units...
  27. ncbi Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model
    Karsten Ruscher
    Department of Experimental Neurology, Charite Hospital, Humboldt University, D 10098 Berlin, Germany
    J Neurosci 22:10291-301. 2002
    In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated whether erythropoietin (EPO) plays a critical role in ischemic preconditioning...
  28. ncbi Erythropoietin after a century of research: younger than ever
    Wolfgang Jelkmann
    Institute of Physiology, University of Luebeck, Luebeck, Germany
    Eur J Haematol 78:183-205. 2007
    In the light of the enthusiasm regarding the use of recombinant human erythropoietin (Epo) and its analogues for treatment of the anaemias of chronic renal failure and malignancies it is worth remembering that today's success has been ..
  29. pmc Erythropoietin deficiency decreases vascular stability in mice
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:526-33. 2008
    b>Erythropoietin (Epo), a hormone known to stimulate bone marrow erythrocyte production, is widely used to treat anemia in patients at risk for vascular disease. However, the effects of Epo on angiogenesis are not well defined...
  30. ncbi Inhibition of erythrocyte cation channels by erythropoietin
    Svetlana Myssina
    Department of Physiology, University of Tubingen, Germany
    J Am Soc Nephrol 14:2750-7. 2003
    Recombinant human erythropoietin therapy is used to counteract anemia that is the result of renal insufficiency. It stimulates the formation of peripheral blood erythrocytes by inhibiting apoptosis of erythrocyte precursor cells...
  31. ncbi Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice
    Xiyong Fan
    Department of Neonatology, University Medical Center Utrecht, Utrecht 3584EA, The Netherlands
    Pediatr Res 69:56-61. 2011
    There are mixed reports on the neuroprotective properties of erythropoietin (EPO) in animal models of birth asphyxia...
  32. ncbi Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes
    Jingfa Zhang
    Laboratory of Clinical Visual Sciences, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Invest Ophthalmol Vis Sci 49:732-42. 2008
    To explore and evaluate the protective effect of erythropoietin (EPO) on retinal cells of chemically induced diabetic rats after EPO was injected intravitreally at the onset of diabetes.
  33. ncbi Erythropoietin ameliorates renal ischemia and reperfusion injury via inhibiting tubulointerstitial inflammation
    Linkun Hu
    Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, PR China
    J Surg Res 176:260-6. 2012
    ..b>Erythropoietin (EPO) has recently been shown to have protective effects on renal IRI by anti-apoptosis and anti-oxidation...
  34. pmc Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways
    Manfred Nairz
    Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, 6020 Innsbruck, Austria
    Immunity 34:61-74. 2011
    b>Erythropoietin (EPO) is the principal cytokine regulating erythropoiesis through its receptor, EPOR. Interestingly, EPORs are also found on immune cells with incompletely understood functions...
  35. pmc Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis
    Sheng Ru Shiou
    Department of Pediatrics, Section of Neonatology, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 286:12123-32. 2011
    ..Human milk is protective against NEC, and the human milk factor erythropoietin (Epo) has been shown to protect endothelial cell-cell and blood-brain barriers...
  36. ncbi Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats
    Xianfang Rong
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, No 83 Fenyang Road, Shanghai, China
    Eur J Pharm Sci 43:334-42. 2011
    This study explored a sustained neuroprotective erythropoietin (EPO) loaded composite microspheres system on injured retinal ganglion cells (RGC)...
  37. ncbi Erythropoietin protects against apoptosis and increases expression of non-neuronal cell markers in the hypoxia-injured developing brain
    Miko Yamada
    Discipline of Medicine, School of Medicine, The University of Queensland at Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia, 4102
    J Pathol 224:101-9. 2011
    b>Erythropoietin (EPO) is a cytokine hormone with cytoprotective effects in many tissues including the brain...
  38. ncbi Activation of the erythropoietin receptor in human skeletal muscle
    Helene Rundqvist
    Section of Molecular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Eur J Endocrinol 161:427-34. 2009
    b>Erythropoietin receptor (EPOR) expression in non-hematological tissues has been shown to be activated by locally produced and/or systemically delivered EPO...
  39. ncbi Protective effects of erythropoietin in cardiac ischemia: from bench to bedside
    Erik Lipsic
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:2161-7. 2006
    b>Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoiesis in the bone marrow. However, recent studies have also shown important nonhematopoietic effects of EPO...
  40. pmc Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
    Erinn B Rankin
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    J Clin Invest 117:1068-77. 2007
    Erythropoiesis is critically dependent on erythropoietin (EPO), a glycoprotein hormone that is regulated by hypoxia-inducible factor (HIF)...
  41. pmc Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
    Laura Calvillo
    Mario Negri Institute of Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 100:4802-6. 2003
    b>Erythropoietin (EPO), originally identified for its critical hormonal role in promoting erythrocyte survival and differentiation, is a member of the large and diverse cytokine superfamily...
  42. ncbi β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 226:3330-9. 2011
    b>Erythropoietin (EPO), the key hormone for erythropoiesis, also increases nitric oxide (NO) bioavailability in endothelial cells (ECs), yet the definitive mechanisms are not fully understood...
  43. ncbi The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression
    Benjamin D Hedley
    Division of Hematology, London Health Sciences Centre, London, Ontario, Canada
    Clin Cancer Res 17:6373-80. 2011
    Over the past few decades, understanding of the physiologic function of erythropoietin (EPO) has evolved significantly...
  44. ncbi Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin
    Steven Fishbane
    Winthrop University Hospital, Mineola, New York, USA
    Kidney Int 68:1337-43. 2005
    Treatment with recombinant human erythropoietin (rHuEPO) has been a major advance for the management of anemia in patients on hemodialysis...
  45. pmc Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
    Ke Liang
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 18:423-35. 2010
    We found that the receptor for erythropoietin (EpoR) is coexpressed with human epidermal growth factor receptor-2 (HER2) in a significant percentage of human breast tumor specimens and breast cancer cell lines...
  46. ncbi JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 74:227-36. 1993
    b>Erythropoietin (EPO) regulates the proliferation and differentiation of erythroid cells through interaction with its receptor (EPOR)...
  47. ncbi Micelle-associated protein in epoetin formulations: aA risk factor for immunogenicity?
    Suzanne Hermeling
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht, The Netherlands
    Pharm Res 20:1903-7. 2003
    ..The aim of this study was to detect the mechanism by which the new formulation may induce these antibodies...
  48. pmc In vivo evidence that erythropoietin protects neurons from ischemic damage
    M Sakanaka
    Department of Anatomy, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Proc Natl Acad Sci U S A 95:4635-40. 1998
    b>Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO...
  49. pmc Identification of an acquired JAK2 mutation in polycythemia vera
    Runxiang Zhao
    Hematology Oncology Division, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 280:22788-92. 2005
    ..The mutant JAK2 has enhanced kinase activity, and when overexpressed together with the erythropoietin receptor in cells, it caused hyperactivation of erythropoietin-induced cell signaling...
  50. ncbi Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    H Wu
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cell 83:59-67. 1995
    b>Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null mutations into both Epo and the EPO receptor (EpoR) gene. Both heterozygotes appeared normal...
  51. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
    ..Previous studies suggest that erythropoietin (EPO) attenuates both processes...
  52. pmc Erythropoietin protects against diabetes through direct effects on pancreatic beta cells
    Diana Choi
    Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A1, Canada
    J Exp Med 207:2831-42. 2010
    ..Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on nonerythroid cells...
  53. pmc Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway
    Alan J Bitonti
    Syntonix Pharmaceuticals, Incorporated, Waltham, MA 02451, USA
    Proc Natl Acad Sci U S A 101:9763-8. 2004
    ..is functional in the lung of non-human primates and that this transport system can be used to deliver erythropoietin (Epo) when it is conjugated to the Fc domain of IgG1...
  54. ncbi Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
    M Digicaylioglu
    Center for Neuroscience and Aging Research, The Burnham Institute, La Jolla, CA 92037, USA
    Nature 412:641-7. 2001
    b>Erythropoietin, a kidney cytokine regulating haematopoiesis (the production of blood cells), is also produced in the brain after oxidative or nitrosative stress...
  55. ncbi Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials
    Julia Bohlius
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 373:1532-42. 2009
    ..We therefore did a meta-analysis of randomised controlled trials in which these drugs plus red blood cell transfusions were compared with transfusion alone for prophylaxis or treatment of anaemia in patients with cancer...
  56. ncbi Control of rHuEPO biological activity: the role of carbohydrate
    Steve Elliott
    Amgen Inc, Thousand Oaks, Calif 91320, USA
    Exp Hematol 32:1146-55. 2004
    Darbepoetin alfa, a novel erythropoiesis-stimulating protein, is a glycosylation analog of recombinant human erythropoietin (rHuEPO) with two additional N-linked carbohydrates...
  57. pmc Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    M L Brines
    The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 97:10526-31. 2000
    b>Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain...
  58. pmc Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells
    Bojana B Beleslin-Cokic
    Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
    Cytokine 54:129-35. 2011
    ..We observed that hypoxia and erythropoietin (EPO) increased erythropoietin receptor (EPOR) gene expression and protein level in HMVEC-L...
  59. pmc Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2
    Thomas Brade
    Sanford Burnham Medical Research Institute, Development and Aging Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 138:139-48. 2011
    ..We found that hepatic expression of erythropoietin (EPO), a secreted factor implicated in myocardial expansion, is dependent on both Raldh2 and Rxra...
  60. ncbi Recombinant human erythropoietin (rhEPO) preconditioning on nuclear factor-kappa B (NF-kB) activation & proinflammatory cytokines induced by myocardial ischaemia-reperfusion
    Xiaoming Liu
    Department of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
    Indian J Med Res 124:343-54. 2006
    b>Erythropoietin (EPO), originally identified for its critical hormonal role in promoting erythrocyte survival and differentiation, has shown to a protective effect in myocardial ischaemia-reperfusion (I-R) injury in animal model...
  61. ncbi Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury
    Paola Cassis
    Transplant Research Center, Chiara Cucchi De Alessandri and Gilberto Crespi Mario Negri Institute for Pharmacological Research, Ranica, Bergamo, Italy
    Kidney Int 81:903-18. 2012
    ..To determine mechanisms by which erythropoietin (EPO) prevents chronic allograft injury we utilized a rat model of full MHC-mismatched kidney transplantation (..
  62. ncbi The expression of erythropoietin triggered by danggui buxue tang, a Chinese herbal decoction prepared from radix Astragali and radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells
    Ken Y Z Zheng
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China
    J Ethnopharmacol 132:259-67. 2010
    ..Pharmacological results indicate that DBT can stimulate the production of erythropoietin (EPO), a specific hematopoietic growth factor, in cultured cells.
  63. ncbi Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha
    Kuo Yun Lu
    Department of Physiology, National Yang Ming University, Taipei 112, Taiwan
    Circulation 121:1828-37. 2010
    In addition to the hematopoietic effect of erythropoietin, increasing evidence suggests that erythropoietin also exerts protective effects for cardiovascular diseases...
  64. pmc Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial
    Samer S Najjar
    Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    JAMA 305:1863-72. 2011
    Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function.
  65. pmc The ergogenic effect of recombinant human erythropoietin on VO2max depends on the severity of arterial hypoxemia
    Paul Robach
    Ecole Nationale de Ski et d Alpinisme, Chamonix, France
    PLoS ONE 3:e2996. 2008
    Treatment with recombinant human erythropoietin (rhEpo) induces a rise in blood oxygen-carrying capacity (CaO(2)) that unequivocally enhances maximal oxygen uptake (VO(2)max) during exercise in normoxia, but not when exercise is carried ..
  66. ncbi Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer
    Jintian He
    Hebei Normal University, Hebei Province, People s Republic of China he
    Int J Pharm 416:69-76. 2011
    The aim of this study was to prepare recombinant human erythropoietin (rhEPO) loaded poly(lactic-co-glycolic acid) (PLGA) microspheres using human serum albumin (HSA) as a stabilizer...
  67. pmc Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice
    Ran Meng
    Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, China
    PLoS ONE 8:e53557. 2013
    b>Erythropoietin (EPO) has multiple biological functions, including the modulation of glucose metabolism. However, the mechanisms underlying the action of EPO are still obscure...
  68. ncbi Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response
    M Brines
    Warren Pharmaceuticals, Ossining, NY 10562, USA
    J Intern Med 264:405-32. 2008
    In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates the number of erythrocytes within the circulation to provide adequate tissue oxygenation...
  69. ncbi Plant recombinant erythropoietin attenuates inflammatory kidney cell injury
    Andrew J Conley
    Department of Biology, University of Western Ontario, London, ON, Canada, N6A 5B7
    Plant Biotechnol J 7:183-99. 2009
    Human erythropoietin (EPO) is a pleiotropic cytokine with remarkable tissue-protective activities in addition to its well-established role in red blood cell production...
  70. ncbi TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells
    Nicolás Pregi
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II, Piso 4, Ciudad Universitaria, C1428EHA, Ciudad Autonoma de Buenos Aires, Argentina
    Exp Cell Res 315:419-31. 2009
    The growth factor erythropoietin (Epo) has shown neuronal protective action in addition to its well known proerythroid activity...
  71. ncbi Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage
    Gang Chen
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Cytokine 45:162-8. 2009
    Previous studies have shown that recombinant human erythropoietin (rhEPO) can attenuate the degree of cerebral vasospasm following experimental subarachnoid hemorrhage (SAH)...
  72. pmc Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production
    Ruifeng Teng
    Molecular Cell Biology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Nat Commun 2:520. 2011
    Although erythropoietin (Epo) is the cytokine known to regulate erythropoiesis, erythropoietin receptor (EpoR) expression and associated activity beyond haematopoietic tissue remain uncertain...
  73. ncbi Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland, and The Ministry of Health, Rabat, Morocco
    Am J Clin Nutr 84:580-6. 2006
    ..The mechanism of these effects is unclear. In vitro and in animal models, vitamin A treatment increases the production of erythropoietin (EPO), a stimulant of erythropoiesis.
  74. pmc A novel protective effect of erythropoietin in the infarcted heart
    Cyrus J Parsa
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Clin Invest 112:999-1007. 2003
    b>Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also increase thrombotic events and mortality rates in patients with ischemic heart disease...
  75. ncbi Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein
    M A Goldberg
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Science 242:1412-5. 1988
    b>Erythropoietin (Epo), the hormone that stimulates red blood cell production, is synthesized in the kidney and liver in response to hypoxia. The human hepatoma cell line Hep3B regulates its production of Epo in a physiologic manner...
  76. ncbi Breast cancer trial with erythropoietin terminated unexpectedly
    Brian Leyland-Jones
    McGill University, Montreal, Canada
    Lancet Oncol 4:459-60. 2003
  77. ncbi ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD
    Jianfeng Shen
    Laboratory of Clinical Visual Sciences, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Invest Ophthalmol Vis Sci 51:35-46. 2010
    To characterize the neuroprotective mechanisms of erythropoietin (EPO) against the stress of glyoxal-advanced glycation end products (AGEs) in retinal neuronal cells.
  78. pmc Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat
    Dong Won Lee
    Department of Internal Medicine, Pusan National University School of Medicine, Seo Gu, Busan, Korea
    J Korean Med Sci 24:S170-5. 2009
    5-lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats...
  79. ncbi Erythropoietin receptor is expressed on human peripheral blood T and B lymphocytes and monocytes and is modulated by recombinant human erythropoietin treatment
    Katarzyna A Lisowska
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Artif Organs 34:654-62. 2010
    b>Erythropoietin receptor (EPO-R) appears on the cell surface in the early stages of erythropoiesis...
  80. ncbi Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models
    Soon Tae Lee
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    J Neurochem 120:115-24. 2012
    Neurovascular degeneration contributes to the pathogenesis of Alzheimer's disease (AD). Because erythropoietin (EPO) promotes endothelial regeneration, we investigated the therapeutic effects of EPO in animal models of AD...
  81. ncbi The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells From clinic to bench - a critical review
    Jolanta Szenajch
    Laboratory for Molecular Oncology, Military Institute of Medicine, Warsaw, Poland
    Biochim Biophys Acta 1806:82-95. 2010
    Recombinant human erythropoietin (rhEPO) has been used clinically to alleviate cancer- and chemotherapy-related anemia. However, recent clinical trials have reported that rhEPO also may adversely impact disease progression and survival...
  82. ncbi A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia
    Iain C Macdougall
    Department of Renal Medicine, King s College Hospital, London
    N Engl J Med 361:1848-55. 2009
    We investigated whether a novel, synthetic, peptide-based erythropoietin-receptor agonist (Hematide, Affymax) can stimulate erythropoiesis in patients with anemia that is caused by antierythropoietin antibodies.
  83. ncbi Erythropoietin improves skeletal muscle microcirculation through the activation of eNOS in a mouse sepsis model
    Raymond L C Kao
    Department of National Defense, Canadian Forces Health Services, Ottawa, Ontario, Canada
    J Trauma 71:S462-7. 2011
    ..One mechanism that leads to organ failure is microcirculatory dysfunction. Erythropoietin (EPO) is a glycoprotein produced by the kidney that primarily regulates erythropoiesis, but it also can exert ..
  84. ncbi Erythropoietin promotes axonal growth in a model of neuronal polarization
    Mark I Ransome
    Neural Regeneration Laboratory, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria 3010, Australia
    Mol Cell Neurosci 38:537-47. 2008
    b>Erythropoietin (EPO) enhances neurogenesis, neuroprotection and regeneration. Here, we examined the effects of EPO on axonal and dendritic growth in a model of neuronal polarization...
  85. pmc Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 108:4986-90. 2011
    ..that NO-induced axonal protection is dependent on hypoxia-inducible factor (HIF)-1-mediated transcription of erythropoietin (EPO) within glial (Schwann) cells present in the cultures...
  86. pmc Cerebral tissue repair and atrophy after embolic stroke in rat: a magnetic resonance imaging study of erythropoietin therapy
    Guangliang Ding
    Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA
    J Neurosci Res 88:3206-14. 2010
    ..DWI, and SWI, respectively) with a 7T system, we tested the hypothesis that treatment of embolic stroke with erythropoietin (EPO) initiated at 24 hr and administered daily for 7 days after stroke onset has benefit in repairing ..
  87. ncbi Erythropoietin improves brain mitochondrial function in rats after traumatic brain injury
    Ye Xiong
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA
    Neurol Res 31:496-502. 2009
    ..Preservation and/or restoration of mitochondrial function may be one of the strategies for neuroprotection. Erythropoietin, a hormone for erythropoiesis, also provides tissue protection against traumatic brain injury and stroke...
  88. ncbi Recombinant human erythropoietin treatment of chronic renal failure patients normalizes altered phenotype and proliferation of CD4-positive T lymphocytes
    Katarzyna A Lisowska
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Artif Organs 34:E77-84. 2010
    Patients with chronic renal failure (CRF) receive recombinant human erythropoietin (rhEPO) for the correction of anemia. However, rhEPO also has an immunomodulatory effect...
  89. pmc Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection
    Eli Gunnarson
    Department of Woman and Child Health, Karolinska Institutet, 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:1602-7. 2009
    ..Here we report that erythropoietin (EPO), which in recent years has emerged as a potent neuro-protective agent, antagonizes the effect of a group ..
  90. ncbi Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: a double blind randomised clinical trial
    J B Springborg
    Department of Neuroanaesthesia, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Acta Neurochir (Wien) 149:1089-101; discussion 1101. 2007
    b>Erythropoietin (EPO) is neuroprotective in experimental models of stroke and subarachnoid haemorrhage (SAH) and possibly in patients with thromboembolic stroke. We studied the efficacy and safety of EPO in patients with SAH.
  91. ncbi Biologically active, magnICON®-expressed EPO-Fc from stably transformed Nicotiana benthamiana plants presenting tetra-antennary N-glycan structures
    Bieke Nagels
    Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Biotechnol 160:242-50. 2012
    ..Here, we report the transient magnICON(®) expression of the erythropoietin fusion protein (EPO-Fc) in Nicotiana benthamiana plants that produce multi-antennary N-glycans without the ..
  92. ncbi Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury
    Shin Kato
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Neurosci Res 89:1566-74. 2011
    The hypoxia-responsive cytokine erythropoietin (EPO) provides neuroprotective effects in the damaged brain during ischemic events and neurodegenerative diseases...
  93. ncbi Erythropoietin activates nitric oxide synthase in murine erythrocytes
    Deyan Mihov
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Am J Physiol Cell Physiol 297:C378-88. 2009
    b>Erythropoietin (Epo) is the main regulator of erythrocyte production and a potent cytoprotective factor. It was suggested that some of Epo cytoprotective properties are due to its regulation of nitric oxide (NO) production...
  94. pmc Epidermal sensing of oxygen is essential for systemic hypoxic response
    Adam T Boutin
    Molecular Biology Section, Division of Biological Sciences, UC San Diego, La Jolla, CA 92093, USA
    Cell 133:223-34. 2008
    ..We have found that epidermal deletion of the hypoxia-responsive transcription factor HIF-1alpha inhibits renal erythropoietin (EPO) synthesis in response to hypoxia...
  95. ncbi Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene
    Christof Dame
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Blood 107:4282-90. 2006
    Molecular mechanisms for the developmental stage and tissue-specific regulation of the erythropoietin (EPO) gene are poorly understood...
  96. pmc Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
    b>Erythropoietin (Epo) is the principal regulator of the erythropoietic response to hypoxic stress, through its receptor, EpoR...
  97. pmc Hypoxic regulation of erythropoiesis and iron metabolism
    Volker H Haase
    Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 299:F1-13. 2010
    ..Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), ..
  98. ncbi Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
    Daisuke Watanabe
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    N Engl J Med 353:782-92. 2005
    ..Hence, it is postulated that there are other potent ischemia-induced angiogenic factors. Erythropoietin possesses angiogenic activity, but its potential role in ocular angiogenesis is not established.
  99. pmc Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
    Lynda A Szczech
    Department of Medicine, The Renal Division, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 74:791-8. 2008
    ..Prospective studies are needed to confirm this relationship and determine safe dosing algorithms for patients unable to achieve target hemoglobin...
  100. pmc Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy
    G D Demetri
    Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Br J Cancer 84:31-7. 2001
    ..Recombinant human erythropoietin (rHuEPO) is an effective therapy to increase haemoglobin values in over half of anaemic cancer patients ..
  101. ncbi Erythropoietin treatment in patients with chronic heart failure: a meta-analysis
    P van der Meer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart 95:1309-14. 2009
    ..However, recent studies in patients with malignancies and renal failure have raised concerns about the safety of these agents...

Research Grants73

  1. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    ..7.5-kDa and 11-kDa. The 11-kDa protein interacts with Grb2, a protein that links the signals mediated by the erythropoietin receptor to the Ras/MEK/ERK pathway in EPCs, and plays an important role in viral DNA replication...
  2. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..of hypoxic injury comprised expression of hypoxia-inducible factor (HIF)-11 in affected hearts and increased erythropoietin levels in several CHB-cord bloods...
  3. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY/ABSTRACT Erythropoietin (Epo) is the principle regulator of red cell production, as it controls the survival, proliferation, and differentiation of erythroid progenitors...
  4. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2012
    ..and as a consequence of preterm delivery when the full switch to post-natal mechanisms of controlling erythropoietin production has not occurred. In sum, these pathological states affect millions of people in the U.S. alone...
  5. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..production of red blood cells (RBCs), is regulated by an intricate network of signals involving the hormone erythropoietin (Epo), and sensing of hypoxia through inhibition of both HIF-1alpha proline hydroxylation and its subsequent ..
  6. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..uptake by 18F- fluoro-deoxy-glucose analogue - positron emission tomography (FDG-PET), high-levels of plasma erythropoietin (Epo) and mobilization of bone marrow progenitors] are present in patients and quantitatively associated with ..
  7. TSAD AS AN EPOR/JAK2 ADAPTOR AND ERYTHROPOIETIC REGULATOR
    DONALD JOSEPH MCCRANN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Erythropoietin (EPO) is used effectively to treat the anemia of chronic renal disease, and can protect damaged cardiac, renal,..
  8. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2011
    The erythropoietin (Epo) receptor is a model for understanding signal transduction mechanisms of the cytokine receptor superfamily...
  9. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    ..Signals generated from Erythropoietin (Epo) binding to its receptor erythropoietin receptor (EpoR) are mediated by JAK2 tyrosine kinase and are ..
  10. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2013
    ..and as a consequence of preterm delivery when the full switch to post-natal mechanisms of controlling erythropoietin production has not occurred. In sum, these pathological states affect millions of people in the U.S. alone...
  11. Novel Erythroid Cell Membrane Protein
    Emery H Bresnick; Fiscal Year: 2010
    While erythropoietin (Epo) is commonly used to treat anemia in patients with cancer and kidney disease, recent studies have raised major safety concerns...
  12. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..cohort, we will investigate whether vitamin D and/or ?-3 FA influence erythropoiesis via hepcidin- and/or erythropoietin (EPO)-dependent pathways...
  13. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..also be important during hematopoiesis, as it is activated by hematopoietic growth factor receptors, such as erythropoietin receptor, c-kit receptor, and fms-like tyrosine kinase 3 (FLT3)...
  14. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The soluble cytokine erythropoietin (Epo) plays a central role in physiologic erythropoiesis and is a mainstay in treatment of human anemias...
  15. Long-acting EPO analog for treating anemia associated with chronic kidney disease
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Anemia typically results from inability of the diseased kidney to produce erythropoietin (EPO), which stimulates production of red blood cells...
  16. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..as FGF-P (binding domain of fibroblast growth factor 2), TPO-P (binding domain shared by thrombopoietin and erythropoietin) and NPY (Neuropeptide Y) and demonstrated that these bioactive peptides exerted certain mitigation effect on ..
  17. Enhancement of Medullary Erythropoiesis during Anemia by Trib3
    David Kuhrt; Fiscal Year: 2013
    ..In chronic disease settings, these bouts often become compromised. Clinically, recombinant human erythropoietin (EPO) and erythropoiesis stimulating agents (ESAs) are used to enhance red cell production during anemia, but ..
  18. Erythropoietin and Neurogenesis after Neonatal Stroke
    FERNANDO FRANCISCO GONZALEZ; Fiscal Year: 2013
    ..that play a major role in brain development;(2) to determine the effects of neonatal stroke and exogenous erythropoietin (EPO) treatment on cell signaling, cell fate, and functional outcome;(3) to gain expertise in basic ..
  19. Pyruvate: Powerful Brain Protection after Cardiac Arrest
    Robert T Mallet; Fiscal Year: 2013
    ..Recently the hormone erythropoietin was shown to protect brain from ischemic injury by activating cytoprotective signaling cascades which suppress ..
  20. Human Milk Factor Protection in Neonatal Necrotizing Enterocolitis
    Sheng Ru Shiou; Fiscal Year: 2012
    ..The objective of this study is to investigate whether the human milk factors erythropoietin (Epo) and transforming growth factor-beta (TGF-b) have protective effects against NEC and to study the ..
  21. Regulating Hematopoietic Stem Cell Homeostasis through GSK-3
    Wei Tong; Fiscal Year: 2013
    ..signaling pathways in hematopoiesis, including Wnt signaling and cytokines such as Thrombopoietin (Tpo) and Erythropoietin, which signal through JAK2 to activate STAT5, Akt, and MAP kinase pathways...
  22. Erythropoietin Blockade for the Treatment of Cancer
    C Anthony Blau; Fiscal Year: 2012
    ..b>Erythropoietin (Epo) is the biggest drug in all of oncology...
  23. Multi-level analysis of iron metabolism and treatment of chronic kidney disease
    Paul L Fox; Fiscal Year: 2013
    ..Treatment of anemia in CKD patients by intravenous injection of iron and erythropoietin (Epo) in combination with dialysis, significantly improves results...
  24. Molecular mechanisms dictating Sirt1/HIF-2 signaling during hypoxia
    JOSEPH ANTHONY GARCIA; Fiscal Year: 2013
    ..HIF-2 is the specific HIF factor responsible for induction of erythropoietin and of major antioxidant enzymes (AOE) in adult mice, thereby regulating cell survival and protective cellular ..
  25. The Aging Kidney: Chronic Injury, Impaired Functions and Clinical Outcomes
    Michael G Shlipak; Fiscal Year: 2013
    ..decline in GFR and abnormalities in kidney endocrine function, including 25 vitamin D hydroxylation and erythropoietin production...
  26. Acute vs. delayed iron therapy: effect on iron status, anemia and cognition
    Chandy C John; Fiscal Year: 2013
    ..Hemoglobin, iron status (ZnPP, ferritin, TfR), erythropoiesis (erythropoietin, reticulocyte count) and inflammation (hepcidin, ferritin, alphal-acid glycoprotein, cytokines) will then be ..
  27. Molecular Mechanisms of the Hypoxic Response
    Frank S Lee; Fiscal Year: 2013
    ..The prototypical HIF target gene is that encoding for Erythropoietin (EPO), a glycoprotein hormone that regulates red blood cell mass in response to changes in oxygen tension...
  28. Brain imaging and developmental follow-up of infants treated with erythropoietin
    Robin K Ohls; Fiscal Year: 2013
    ..One promising intervention is the use of recombinant erythropoietin (Epo, also known as an erythropoiesis stimulating agent, or ESA)...
  29. Preterm Epo Neuroprotection Trial (PENUT Trial) CCC
    Sandra E Juul; Fiscal Year: 2013
    ..New approaches are needed to improve these outcomes. Recombinant erythropoietin (Epo) is a promising novel neuroprotective agent...
  30. Directed Evolution of Blood Brain Barrier-Traversing Granulocyte Colony-Stimulati
    PETER J HEINZELMAN; Fiscal Year: 2013
    ..therapeutic neurotrophic factors, particularly granulocyte macrophage colony-stimulating factor (GM-CSF) and erythropoietin (EPO), for increased BBB-traversal and neurotrophic activity duration...
  31. Myocardial Effects of Erythropoietin During Resuscitation from Cardiac Arrest
    RAUL JAIME GAZMURI; Fiscal Year: 2013
    ..Yet, the discovery that erythropoietin activates potent cell protective mecha- nisms (many of which converge on mitochondria) may provide the means ..
  32. Preterm Epo Neuroprotection Trial (PENUT Trial) DCC
    Patrick J Heagerty; Fiscal Year: 2013
    ..New approaches are needed to improve these outcomes. Recombinant erythropoietin (Epo) is a promising novel neuroprotective agent...
  33. BMP4 dependent stress erythropoiesis pathway in short-term radioprotection
    ROBERT FRANK PAULSON; Fiscal Year: 2013
    ..however, suggests that the primary therapies for anemia, transfusion therapy and treatment with recombinant erythropoietin (Epo), can themselves cause pathology...
  34. Studies on Serial Phlebotomy in Voluntary Blood Donors
    Stuart D Katz; Fiscal Year: 2013
    ..of iron stores and oxidative stress, red cell and plasma volume, regional arterial wall shear stress, and erythropoietin levels will be obtained before and after the assigned study intervention...
  35. Novel Therapy and Mechanisms in Glaucoma
    Tonia S Rex; Fiscal Year: 2013
    ..We offer an alternative IOP-independent neuroprotective therapy, a modified form of erythropoietin (EPO). EPO is already FDA approved for the treatment of anemia...
  36. Signals for Post-pneumonectomy Compensatory Lung Growth
    Connie C W Hsia; Fiscal Year: 2013
    ..vivo tissue mechanical stress to cellular response has not been established, but the hypoxia-inducible factor-erythropoietin-vascular endothelial growth factor (HIF-EPO- VEGF) axis is implicated...
  37. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Woodrow Benson; Fiscal Year: 2010
    ..to investigate whether preoperative administration of glucocorticoids (methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the incidence of LCOS for ..
  38. Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
    Carl J Pepine; Fiscal Year: 2013
    ..include anti-ischemia therapies, such as ranolazine and dipyridamole, as well as novel interventions, such as erythropoietin and stem-cell therapy, targeting coronary vascular function...
  39. Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
    Stuart Lipton; Fiscal Year: 2009
    ..In attempting to prevent this type of HIV-related neurotoxicity, we discovered that erythropoietin (EPO), normally thought to be a kidney-generated cytokine, is made in the brain and is neuroprotective...
  40. Elucidation of Novel Anti-apoptotic Pathways in Erythropoiesis
    Yongping Wang; Fiscal Year: 2013
    ..pathways modulated by his shRNAs during erythropoietic differentiation, either alone or in cooperation with erythropoietin signaling...
  41. Mechanisms of Impaired Erythropoiesis in Post Burn Anemia of Critical Illness
    KUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2013
    ..Reduced erythrocyte production due to lack of erythropoietin (Epo) could contribute to anemia...
  42. Mechanisms of tumor resistance to anti-HER/ErbB therapeutics
    Zhen Fan; Fiscal Year: 2012
    ..In this proposal, we will explore whether erythropoietin (EPO)-induced cell signaling plays a role in breast cancer resistance to trastuzumab...
  43. JAK2 signaling in erythropoiesis
    LILY JUNSHEN HUANG; Fiscal Year: 2013
    ..Aim 2 will use both in vitro and in vivo experiments to characterize how JAK2 directs endocytosis of the erythropoietin receptor to terminate signaling...
  44. Epo regulated erythropoiesis
    Don Wojchowski; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Important new actions of erythropoietin (EPO) are increasingly being realized in the contexts of ischemic cytoprotection, angiogenesis, thrombosis and the anemia of cancer and chemotherapy...
  45. Klotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney Injury
    Ming Chang Hu; Fiscal Year: 2013
    ..HIF1/2 activation protects the kidney from IRI. Erythropoietin (EPO) has also been used for treatment of ischemic injury in the brain, heart, and kidney...
  46. Dynamic Regulation of Erythropoietin Gene Expression in Mammals
    JOSEPH ANTHONY GARCIA; Fiscal Year: 2013
    ..have improved over the past several decades, almost all current therapies involve bolus administration of erythropoietin (epo), an endocrine factor produced in the adult kidney and also in the liver with severe anemia...
  47. Mechanisms of Oxygen Sensing
    ROBERT BRIAN HAMANAKA; Fiscal Year: 2010
    ..Epidermis acts as an oxygen sensor by regulating blood flow to the kidneys, which produce erythropoietin during hypoxia...
  48. Cooperative Multicenter Network of Neontal Intensive Care Units
    Seetha Shankaran; Fiscal Year: 2013
    ..Athina Pappas has submitted a concept protocol in this application on Erythropoietin as Neuroprotection for Neonatal Intracranial Hemorrhage among ELBW Infants...
  49. Conjugation of polysialic acid to biologics in glycoengineered Escherichia coli
    ADAM CHARLES FISHER; Fiscal Year: 2010
    ..PSA is being developed for clinical use and polysialylated versions of insulin and erythropoietin have displayed improved tolerance and pharmacokinetics...
  50. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..IGF-I signaling in sympathetic ganglia may be bypassed by the newly discovered neurotrophic effect of erythropoietin (EPO), an agent which influences the same ganglionic PI3K/Akt signaling pathway as IGF-I and is approved for ..
  51. DNA Replication and Genome-Wide Demethylation in Erythropoiesis
    Merav Socolovsky; Fiscal Year: 2013
    ..We hypothesize that disruption of global erythroid demethylation may underlie syndromes of erythropoietin-resistant anemias...
  52. Synthesis of a homogenous erythropoietin via iterative native chemical and alanin
    PAUL ANTHONY VADOLA; Fiscal Year: 2013
    ..Consequently the production and maintenance of red blood cells are critical processes for our survival. Erythropoietin (EPO) is a naturally occurring hormone that is responsible for these tasks...
  53. Erythropoietin-encoding mRNA for treatment of anemia
    Katalin Kariko; Fiscal Year: 2010
    The product that will result from this proposal is a nucleoside-modified mRNA encoding erythropoietin for treatment of red blood cell deficiency (anemia)...
  54. Mechanisms of Neonatal Erythropoietin Neuroprotection
    Shenandoah Robinson; Fiscal Year: 2011
    ..Neural cell loss occurs primarily by apoptosis with failure of new waves of progenitors to survive. Erythropoietin (EPO) and its cognate receptor EPOR are required for prenatal brain development, especially in the second half ..
  55. Southern Oncology Network on Adverse Reactions (SONAR) - Focus on Tyrosine Kinase
    RICHARD MICHAEL SCHULZ; Fiscal Year: 2013
    ..g. erythropoietin/darbepoetin)...
  56. A novel mechanism of coagulation in sickle cell disease
    JULIA BRITTAIN; Fiscal Year: 2012
    ..Furthermore we show that erythropoietin (EPO), a cytokine involved in erythropoiesis, promotes the binding of the sRetic to the monocytes...
  57. CNS vulnerability to systemic chemotherapy: Causes and prevention
    Mark D Noble; Fiscal Year: 2012
    ..for reducing or preventing such damage, and is focused on analysis of the hypothesis that co-treatment with erythropoietin (EPO) reduces CNS damage caused by chemotherapy...
  58. Modulation of In Vivo Tumor Oxygenation via Polymersome-encapsulated Myoglobin
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2011
    ..50 years, previous attempts to improve tumor oxygenation, including whole-body hyperbaric oxygen and systemic erythropoietin treatments, have had limited success. Vindico NanoBioTechnology, Inc...
  59. Erythropoietin and Breast Cancer Stem Cells
    Frank Pajonk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This study explores if radiation and erythropoietin (Epo) synergize to alter the self-renewal of breast cancer stem cells (BCSCs) and to reprogram differentiated breast cancer (BC) cells into induced ..
  60. Nanoparticle Drug Delivery in Post-Pneumonectomy Compensatory Lung Growth
    Kytai Truong Nguyen; Fiscal Year: 2013
    ..all-trans retinoic acid (RA), peptide or cDNA of keratinocyte growth factor (KGF) and its receptor (KGFR), or erythropoietin (EPO) and its receptor (EPOR), to be administered in combination to proportionally stimulate the alveolar ..
  61. Early Biomarkers in Neonatal Brain Injury
    Sonia L Bonifacio; Fiscal Year: 2013
    ..An exciting therapeutic emerging in pilot clinical trials is erythropoietin (EPO)...
  62. Novel biomarker validation and dosing algorithms for anemia management in ESRD
    Michael L Merchant; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Erythropoietin (EPO) and erythropoiesis-stimulating agents (ESAs) are used to treat the anemia of chronic renal disease in greater than 90% of all in-center hemodialysis patients at a cost of ..
  63. Iron Delivery Via hemodialysate in ESRD
    Ajay Gupta; Fiscal Year: 2005
    b>Erythropoietin (EPO) is an effective therapy for anemia of end-stage renal disease (ESRD) and is used in almost all ESRD patients receiving chronic hemodialysis...
  64. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..uptake by 18F- fluoro-deoxy-glucose analogue - positron emission tomography (FDG-PET), high-levels of plasma erythropoietin (Epo) and mobilization of bone marrow progenitors] are present in patients and quantitatively associated with ..
  65. Epo Neuroprotection of ELBW Infants: Planning Grant
    Sandra E Juul; Fiscal Year: 2010
    ..research plan in order to carry out a multicenter randomized controlled trial of high dose recombinant erythropoietin (rEpo) as an early intervention to improve long-term neurological outcomes in extremely low birth weight ..
  66. Model to study the effects of ethanol on erythropoiesis
    Stephen Koury; Fiscal Year: 2001
    ..Proposed mechanisms for red cell abnormalities in alcoholic patients include attenuation of erythropoietin (EPO) production by ethanol, decreased sensitivity of erythroid precursor cells to EPO, direct toxic effects ..
  67. ERYTHROPOIETIN AND THE REGULATION OF ERYTHROPOIESIS
    Sanford Krantz; Fiscal Year: 2003
    ..BFU-E) and colony-forming units- erythroid (CFU) have been highly purified and the evolution of BFU- erythropoietin (EPO) receptors as well as response to EPO, stem cell factor (SCF), interleukin-3 (IL-3) and insulin-like ..
  68. RADIOASSAY OF ERYTHROPOIETIN
    GISELA CLEMONS; Fiscal Year: 1991
    b>Erythropoietin is now accepted as the hormone controlling red blood cell production...
  69. IN VIVO SIGNALING OF THE ERYTHROPOIETIN RECEPTOR
    Saghi Ghaffari; Fiscal Year: 2002
    DESCRIPTION (Applicant's Description): Erythropoietin-Receptor (EPO-R) signaling is crucial for differentiation, proliferation and survival of mature erythroid progenitor cells...
  70. Erythropoietin receptor /Janus Kinase 2 complex
    Lily Huang; Fiscal Year: 2006
    The erythropoietin receptor (EpoR) is the primary regulator of mammalian erythropoiesis. The EpoR lacks intrinsic catalytic activity and relies on Janus Kinase 2 (JAK2) for signal transduction...
  71. Molecular Biology of Polycythemia
    Josef Prchal; Fiscal Year: 2007
    ..PFCP), which provides a model for studying the alterations of the control of erythropoiesis by augmented erythropoietin (Epo) activity...
  72. ERYTHROPOIETIN THERAPY IN RENAL FAILURE
    JOSEPH ESCHBACH; Fiscal Year: 1991
    ..with chronic renal failure, some improve their anemia, most likely because of increased renal and/or non-renal erythropoietin (Ep) production...
  73. ERYTHROPOIETIN RECEPTOR REGULATION OF ERYTHROPOIESIS
    MURAT ARCASOY; Fiscal Year: 2002
    ..is to study the molecular and cellular mechanisms involved in the regulation of erythropoiesis mediated by the erythropoietin receptor (EpoR), the expression of which is essential for norma erythroid development...