bleomycin

Summary

Summary: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

Top Publications

  1. ncbi Intracystic bleomycin therapy for craniopharyngioma in children: the Canadian experience
    Juliette Hukin
    Division of Neurology and Oncology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Cancer 109:2124-31. 2007
  2. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
  3. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
  4. pmc Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:535-52. 2010
  5. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
  6. doi Modeling pulmonary fibrosis with bleomycin
    Marios A Mouratis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Curr Opin Pulm Med 17:355-61. 2011
  7. pmc Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    Gregory F Sonnenberg
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 207:1293-305. 2010
  8. pmc Selective tumor cell targeting by the disaccharide moiety of bleomycin
    Zhiqiang Yu
    Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA
    J Am Chem Soc 135:2883-6. 2013
  9. pmc Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E1475-83. 2011
  10. pmc Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury
    Yuben Moodley
    Department of Medicine, Monash Immunology and Stem Cell Laboratories, School of Biomedical Sciences, Monash University, Melbourne, Australia
    Am J Pathol 175:303-13. 2009

Research Grants

  1. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
  2. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
  3. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
  4. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
  5. THEA NOREEN GOLDEN; Fiscal Year: 2015
  6. Robert Paine; Fiscal Year: 2016
  7. Bethany B Moore; Fiscal Year: 2016
  8. ROBERT MATTHEW TIGHE; Fiscal Year: 2016
  9. Yvonne M W Janssen-Heininger; Fiscal Year: 2016
  10. Irina G Luzina; Fiscal Year: 2016

Detail Information

Publications402 found, 100 shown here

  1. ncbi Intracystic bleomycin therapy for craniopharyngioma in children: the Canadian experience
    Juliette Hukin
    Division of Neurology and Oncology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Cancer 109:2124-31. 2007
    ..Intracystic therapies have been utilized in some centers to potentially decrease morbidity associated with cystic craniopharyngioma. The aim of the study was to review the Canadian experience with intracystic bleomycin therapy (ICB).
  2. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
    ..Here we systemically administered MSCs purified by immunodepletion from male bleomycin (BLM)-resistant BALB/c mice into female BLM-sensitive C57BL/6 recipients and quantified engraftment levels in ..
  3. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
    ..circulating fibrocytes migrates in response to CXCL12 and traffics to the lungs in a murine model of bleomycin-induced pulmonary fibrosis...
  4. pmc Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:535-52. 2010
    ..After exposure to bleomycin (BLM), but not Schistosoma mansoni eggs, IL-17A produced by CD4(+) and gammadelta(+) T cells induced significant ..
  5. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
    ..These data identify a novel mechanism for locally regulating TGF beta 1 function in vivo by regulating expression of the alpha v beta 6 integrin...
  6. doi Modeling pulmonary fibrosis with bleomycin
    Marios A Mouratis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Curr Opin Pulm Med 17:355-61. 2011
    ..Here, we summarize the characteristics of the bleomycin animal model, the most commonly used model of pulmonary fibrosis, highlighting recent advances it has led us to ..
  7. pmc Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    Gregory F Sonnenberg
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 207:1293-305. 2010
    ..We demonstrate that after administration of a high dose of bleomycin that induces acute tissue damage and airway inflammation and is lethal to wild-type (WT) mice, Th17 cell-derived ..
  8. pmc Selective tumor cell targeting by the disaccharide moiety of bleomycin
    Zhiqiang Yu
    Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA
    J Am Chem Soc 135:2883-6. 2013
    In a recent study, the well-documented tumor targeting properties of the antitumor agent bleomycin (BLM) were studied in cell culture using microbubbles that had been derivatized with multiple copies of BLM...
  9. pmc Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E1475-83. 2011
    ..Rather, bleomycin accelerates the previously reported conversion of AEC2 into AEC1 cells...
  10. pmc Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury
    Yuben Moodley
    Department of Medicine, Monash Immunology and Stem Cell Laboratories, School of Biomedical Sciences, Monash University, Melbourne, Australia
    Am J Pathol 175:303-13. 2009
    ..from Wharton's jelly with a phenotype consistent with mesenchymal stem cells (uMSCs) in the treatment of a bleomycin-induced mouse model of lung injury...
  11. pmc Bone marrow-derived progenitor cells in pulmonary fibrosis
    Naozumi Hashimoto
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 113:243-52. 2004
    ..Induction of pulmonary fibrosis in such chimera mice by endotracheal bleomycin (BLM) injection caused large numbers of GFP(+) cells to appear in active fibrotic lesions, while only a few GFP(+..
  12. doi Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function
    Sean Murphy
    The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Australia
    Cell Transplant 20:909-23. 2011
    ..explore the mechanisms by which hAECs reduce pulmonary fibrosis and enhance lung regeneration, we utilized a bleomycin-induced model of pulmonary fibrosis and investigated the ability of hAECs to reduce fibrosis and thereby improve ..
  13. pmc Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
    Fengrong Zuo
    Roche Bioscience, Palo Alto, CA 94304 Functional Genomics, and Institute of Respiratory Medicine, Sheba Medical Center, Tel Hashomer, 52621 Israel
    Proc Natl Acad Sci U S A 99:6292-7. 2002
    ..matrilysin knockout mice were dramatically protected from pulmonary fibrosis in response to intratracheal bleomycin. Our results identify matrilysin as a mediator of pulmonary fibrosis and a potential therapeutic target...
  14. pmc IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
    Pamela Gasse
    Laboratory of Molecular Immunology and Embryology, University of Orleans and CNRS, Orleans, France
    J Clin Invest 117:3786-99. 2007
    ..b>Bleomycin insult results in expression of neutrophil and lymphocyte chemotactic factors, chronic inflammation, remodeling, ..
  15. ncbi Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, MA 02129, USA
    Am J Respir Cell Mol Biol 31:395-404. 2004
    ..We found that IP-10 is highly expressed in a mouse model of pulmonary fibrosis induced by bleomycin. IP-10-deficient mice exhibited increased pulmonary fibrosis after administration of bleomycin, suggesting that ..
  16. doi Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    Pamela Gasse
    University of Orleans and CNRS, Orleans, France
    Am J Respir Crit Care Med 179:903-13. 2009
    ..The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood...
  17. ncbi Attenuation of bleomycin-induced pulmonary fibrosis by follistatin
    Fumiaki Aoki
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371 8512, Japan
    Am J Respir Crit Care Med 172:713-20. 2005
    ..Activins are members of the transforming growth factor-beta superfamily thought to be involved in repair processes after tissue injury...
  18. pmc The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    Antje Moeller
    Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontario, Canada
    Int J Biochem Cell Biol 40:362-82. 2008
    ..The most common is the bleomycin model in rodents (mouse, rat and hamster)...
  19. pmc Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis
    Harikrishna Tanjore
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 180:657-65. 2009
    ..Lung fibroblasts are key mediators of fibrosis resulting in accumulation of excessive interstitial collagen and extracellular matrix, but their origins are not well defined...
  20. pmc Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis
    Arnau Ulsamer
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:5164-72. 2012
    ..Mice given a tankyrase inhibitor (50 mg/kg orally) daily for 7 days beginning 10 days after intratracheal bleomycin had improved survival over controls...
  21. ncbi Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis
    Tae Hyung Kim
    Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
    Tohoku J Exp Med 223:45-54. 2011
    ..We examined whether inhibition of the Wnt/β-catenin pathway could attenuate pulmonary fibrosis in a bleomycin-induced murine model of pulmonary fibrosis...
  22. ncbi Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation
    K A Robertson
    Herman B. Wells Center for Pediatric Research, Department of Pediatrics, James Whircomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer Res 61:2220-5. 2001
    ..in the oligonucleotide cleavage assay, and this was reflected in a 2-3-fold increase in protection against bleomycin. Lesser protection was observed with gamma-irradiation...
  23. ncbi The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..We show that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from ..
  24. pmc Hypersensitivity to DNA damage in plant stem cell niches
    Nick Fulcher
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 106:20984-8. 2009
    ..We propose that plants have independently evolved selective death as a stringent mechanism to safeguard genome integrity in their stem cell populations...
  25. doi Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis
    Michael A Gibbons
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 184:569-81. 2011
    ..Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial...
  26. pmc Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    D T Eitzman
    Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Clin Invest 97:232-7. 1996
    ..the relationship between the fibrinolytic system and pulmonary fibrosis, lung inflammation was induced by bleomycin in transgenic mice that either overexpressed or were completely deficient in murine plasminogen activator ..
  27. pmc Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    Mauricio Rojas
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Department of Medicine, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 33:145-52. 2005
    We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any protective effects conferred by bone marrow-derived mesenchymal stem cell (BMDMSC)..
  28. ncbi Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
    A Espana
    Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Navarra, Spain
    Dermatol Surg 27:23-7. 2001
    The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions.
  29. doi Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling
    Narayanan Sriram
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India
    Pulm Pharmacol Ther 22:221-36. 2009
    ..of antioxidant activities and resolved inflammation after epigallocatechin-3-gallate (EGCG) treatment during bleomycin-induced pulmonary fibrosis is investigated in this study...
  30. pmc Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis
    Susana Aguilar
    Centre for Respiratory Research, Rayne Institute, University College London, London, United Kingdom
    PLoS ONE 4:e8013. 2009
    ..We used the in vivo bleomycin-induced lung fibrosis model to assess the potential therapeutic effect of MSCs and HSCs...
  31. pmc A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
    J S Swaney
    Amira Pharmaceuticals, San Diego, CA 92121, USA
    Br J Pharmacol 160:1699-713. 2010
    ....
  32. doi Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice
    Remo C Russo
    Universidade Federal de Minas Gerais, Avenida Antonio Carlos, Belo Horizonte, MG, Brazil
    J Leukoc Biol 89:269-82. 2011
    ..with pulmonary inflammation, angiogenesis, and deposition of collagen and is modeled by instillation of bleomycin. The role of PI3Kγ in mediating bleomycin-induced pulmonary inflammation and fibrosis in mice and potential ..
  33. pmc TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment
    Amber L Degryse
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 300:L887-97. 2011
    ..transforming growth factor-β (TGFβ) signaling in lung epithelium impacts lung fibrosis in the intratracheal bleomycin model...
  34. pmc Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury
    Huaiyong Chen
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Durham, North Carolina, USA
    Stem Cells 30:1948-60. 2012
    ..Colony-forming ability was reduced for each progenitor cell type after in vivo bleomycin exposure, but only CD24(low) GFP(hi) progenitors showed robust expansion during tissue remodeling...
  35. pmc Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza
    Dahai Zheng
    Interdisciplinary Research Group in Infectious Diseases, Singapore Massachusetts Institute of Technology Alliance for Research and Technology, Singapore, Singapore
    PLoS ONE 7:e48451. 2012
    ..We show that following severe alveolar damage induced either by bleomycin or by infection with influenza virus, the majority of the newly generated alveolar type II cells in the damaged ..
  36. ncbi Antifibrotic effects of CXCR4 antagonist in bleomycin-induced pulmonary fibrosis in mice
    Hideki Makino
    Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 60:127-37. 2013
    ..To explore the antifibrotic effects of blockade of CXCR4, we used a specific antagonist for CXCR4, AMD3100, in bleomycin-induced pulmonary fibrosis model in mice...
  37. pmc Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
    Br J Cancer 84:565-70. 2001
    ..The aim of this study was to evaluate the cytotoxicity of electroporation with bleomycin or cisplatin on cultured human microvascular endothelial cells (HMEC-1)...
  38. pmc Gender-based differences in bleomycin-induced pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    Department of Internal Medicine, University of Michigan Medical School, 210 Washtenaw, Box 2216, Ann Arbor, MI 48109 2216, USA
    Am J Pathol 166:1593-606. 2005
    ..influence on pulmonary fibrosis, male and female rats were given endotracheal injections of either saline or bleomycin. Female rats showed higher mortality rates and more severe fibrosis than did male rats, as indicated by higher ..
  39. pmc Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation
    Ting Xie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Physiol Genomics 43:479-87. 2011
    ..in the regulation of lung fibrosis, total RNA was isolated from mouse lungs harvested at different days after bleomycin treatment, and miRNA array with 1,810 miRNA probes was performed thereafter...
  40. doi CCN2 is required for bleomycin-induced skin fibrosis in mice
    Shangxi Liu
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 63:239-46. 2011
    ..The aim of this study was to assess whether adult mice bearing a smooth muscle cell/fibroblast-specific deletion of CCN2 are resistant to bleomycin-induced skin scleroderma.
  41. ncbi Two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine plus extended-field radiotherapy is superior to radiotherapy alone in early favorable Hodgkin's lymphoma: final results of the GHSG HD7 trial
    Andreas Engert
    First Department of Internal Medicine, Coordination Center for Clinical Trials, and Department of Radiotherapy, University Hospital of Cologne, Cologne, Germany
    J Clin Oncol 25:3495-502. 2007
    To investigate whether combined-modality treatment (CMT) with two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by extended-field radiotherapy (EF-RT) is superior to EF-RT alone in patients with early ..
  42. ncbi Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
    Jingsong Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Lung Cell Mol Physiol 282:L585-93. 2002
    ..Using mice without Smad3 gene expression, we investigated whether Smad3 could regulate bleomycin-induced pulmonary fibrosis in vivo...
  43. pmc Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration
    Yuko Ishida
    Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Pathol 170:843-54. 2007
    ..the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF)...
  44. doi Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis
    Anna Cargnoni
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
    Cell Transplant 18:405-22. 2009
    ..On these bases, we studied the effects of fetal membrane-derived cells on a mouse model of bleomycin-induced lung fibrosis...
  45. ncbi Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: report of an intergroup trial
    David B Duggan
    Department of Medicine, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    J Clin Oncol 21:607-14. 2003
    In a series of trials, doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and mechlorethamine, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (MOPP/ABV) have been identified as effective ..
  46. ncbi Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells
    Josephine M Atienza
    Sequenom, Inc, 3595 John Hopkins Court, San Diego, CA 92121, USA
    Mol Cancer Ther 4:361-8. 2005
    ..Moreover, MCF-7 cell sensitivity to two DNA-damaging chemotherapeutic agents, etoposide and bleomycin, was increased after inhibition of RAD21 expression with a dose reduction factor 50 (DRF50) of 1.42 and 3...
  47. pmc Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
    Xiao Mei Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 203:2895-906. 2006
    ..We also demonstrated that cav-1 markedly ameliorated bleomycin (BLM)-induced pulmonary fibrosis, as indicated by histological analysis, hydroxyproline content, and immunoblot ..
  48. pmc Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma
    G Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Br J Cancer 98:388-98. 2008
    ..In the study, SA-1 solid subcutaneous sarcoma tumours in A/J mice were treated by bleomycin (BLM) given intravenously (1 mg kg(-1)), application of electric pulses (8 pulses, 1040 V, 100 micros, 1 Hz) or ..
  49. doi Therapeutic effects of bone marrow-derived mesenchymal stem cells engraftment on bleomycin-induced lung injury in rats
    F Zhao
    Department of Respiratory, Xijing Hospital, Xi an, China
    Transplant Proc 40:1700-5. 2008
    ..that bone marrow-derived mesenchymal stem cell (MSC) engraftment attenuated lung injury in a model induced by bleomycin in mice. However, the mechanisms are not completely understood...
  50. pmc Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages
    Lynne A Murray
    Promedior, Inc, Malvern, Pennsylvania, United States of America
    PLoS ONE 5:e9683. 2010
    ..SAP therapeutically inhibits established bleomycin-induced pulmonary fibrosis, when administered systemically or locally to the lungs...
  51. pmc Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10
    Emilio García-Prieto
    Department of Biología Funcional, Universidad de Oviedo, Instituto Universitario de Oncologia IUOPA, Oviedo, Spain
    PLoS ONE 5:e13242. 2010
    ..Matrix metalloproteinases (MMPs) may have pro and antifibrotic roles within the lungs, due to its ability to modulate collagen turnover and immune mediators. MMP-8 is a collagenase that also cleaves a number of cytokines and chemokines...
  52. pmc Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
    Keunhee Oh
    Laboratory of Immunology, Department of Biomedical Sciences Transplantation Research Institute, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Exp Med 208:1707-19. 2011
    ..Here, we show that in a lung injury model, bleomycin induced the secretion of IL-6 by epithelial cells in a transglutaminase 2 (TG2)-dependent manner...
  53. pmc Curing metastatic testicular cancer
    Lawrence H Einhorn
    Indiana University Medical Center, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202 5289, USA
    Proc Natl Acad Sci U S A 99:4592-5. 2002
    Our initial studies with cisplatin + vinblastine + bleomycin began 27 years ago in 1974, changing the cure rate for disseminated disease from 5 to 60%...
  54. ncbi Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis
    Hiroyuki Higashiyama
    Pharmacology Department, Tsukuba Research Laboratories, GlaxoSmithKline KK, 43 Wadai, Tsukuba, Ibaraki, 300 4247, Japan
    Exp Mol Pathol 83:39-46. 2007
    ..CTGF, myofibroblast marker (alpha-smooth muscle actin; aSMA) and type I collagen deposition in the lung using Bleomycin (BLM)-induced pulmonary fibrosis model...
  55. pmc Pivotal role of cathepsin K in lung fibrosis
    Frank Buhling
    Department of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Am J Pathol 164:2203-16. 2004
    ..We compared the induction of lung fibrosis by administration of bleomycin. CTSK(-/-) mice deposited significantly more extracellular matrix than control mice...
  56. ncbi Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes. A comet assay study
    L Benitez-Bribiesca
    Oncological Research Unit, Oncology Hospital, IMSS, Mexico, DF, Mexico
    Ann N Y Acad Sci 887:133-49. 1999
    ..dsb, respectively) and apoptosis in normal human lymphocytes and rat thymocytes subjected to the action of H2O2, bleomycin and ionizing radiation...
  57. ncbi Bleomycin-induced pulmonary injury in mice deficient in SPARC
    R C Savani
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 279:L743-50. 2000
    ..We therefore investigated the development of pulmonary fibrosis induced by bleomycin administered either intratracheally or intraperitoneally in mice deficient in SPARC. Bleomycin (0...
  58. pmc Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells
    A S Balajee
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University, VC 11, Room 243, 630 West, 168th Street, New York, NY 10032, USA
    Nucleic Acids Res 29:1341-51. 2001
    ..We also analyzed the PCNA complex induced by a radiomimetic agent, Bleomycin (BLM), which produces predominantly single- and double-strand DNA breaks...
  59. ncbi Decreased expression of aquaporin-5 in bleomycin-induced lung fibrosis in the mouse
    Esteban C Gabazza
    Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Pathol Int 54:774-80. 2004
    ..Lung fibrosis was induced by intratracheal and by subcutaneous infusion of bleomycin. The expression of aquaporin-5 was investigated by immunohistochemical studies and by polymerase chain reaction...
  60. pmc Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis
    Francois Huaux
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Pathol 167:1485-96. 2005
    ..The present study examined the pulmonary expression of CCL11 and CCR3 during bleomycin (blm)-induced lung injury and determined their importance in the recruitment of inflammatory cells and the ..
  61. pmc In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung
    K Nakagome
    Pulmonary Division, Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Thorax 61:886-94. 2006
    ..A study was undertaken to examine whether IL-10 affects the production and activation of TGF-beta and thus can attenuate the fibrosis...
  62. pmc E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis
    Mayuka Horikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 169:740-9. 2006
    The development of bleomycin-induced lung injury, which is a model of pulmonary fibrosis, results from inflammatory cell infiltration, a process highly regulated by the expression of multiple adhesion molecules...
  63. ncbi Telomerase activity in bleomycin-induced epithelial cell apoptosis and lung fibrosis
    Z G Fridlender
    Lung Cellular and Molecular Biology Laboratory, Institute of Pulmonary Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Eur Respir J 30:205-13. 2007
    Epithelial cell injury and apoptosis are recognised as early features in idiopathic pulmonary fibrosis and bleomycin-induced fibrosis in mice. Telomerase is a known apoptosis-alleviating factor...
  64. doi Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice
    Xiao hong Chen
    Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China
    Clin Exp Pharmacol Physiol 36:146-53. 2009
    ..One group was a control group; the remaining four groups were treated with intratracheal instillation of 3 mg/kg bleomycin (BLM). The following day, emodin (5, 10 or 20 mg/kg per day, p.o...
  65. pmc Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin
    Hua Fung
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 286:4968-77. 2011
    Ionizing radiation (IR) and bleomycin (BLM) are used to treat various types of cancers. Both agents generate cytotoxic double strand breaks (DSB) and abasic (apurinic/apyrimidinic (AP)) sites in DNA...
  66. doi MEK inhibition suppresses the development of lung fibrosis in the bleomycin model
    Maria Galuppo
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Italy
    Naunyn Schmiedebergs Arch Pharmacol 384:21-37. 2011
    ..Lung injury was induced by intratracheal instillation of bleomycin (1 mg/kg), and PD98059 (10 mg/kg, 10% dimethyl sulfoxide, i.p...
  67. pmc Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury
    Yoshinori Aono
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Crit Care Med 185:525-36. 2012
    ..It has been reported that patients with idiopathic pulmonary fibrosis (IPF) often have elevated serum levels of SP-A and SP-D, although their role in the disease is not known...
  68. doi Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury
    G J Rey-Parra
    Department of Pediatrics, Women and Children Health Research Institute, Cardiovascular Research Center, Pulmonary Research Group, University of Alberta, Edmonton, Canada
    J Mol Med (Berl) 90:637-47. 2012
    ..We hypothesized that ACE2 prevents Bleomycin (BLM)-induced lung injury...
  69. pmc Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii
    Laurent Dortet
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:1693-7. 2012
    ..The ble(MBL) gene encodes a novel bleomycin resistance protein (BRP), named BRP(MBL), that shares weak similarities with known BRPs (less than 60% amino ..
  70. pmc miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice
    Jun Xiao
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Ther 20:1251-60. 2012
    ..The present study investigated whether miR-29 had therapeutic potential for lung disease induced by bleomycin in mice...
  71. doi Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice
    Ruchit Trivedi
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Nanotechnology 23:505101. 2012
    ..Efficacy was tested in C57Bl/6 mice in a bleomycin-induced pulmonary fibrosis model...
  72. pmc The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis
    Ajit A Kulkarni
    The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e63798. 2013
    ..we hypothesized that CDDO-Me would reduce lung inflammation, fibrosis and lung function impairment in a bleomycin model of lung injury and fibrosis...
  73. pmc The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5
    Mustapha Aouida
    Maisonneuve Rosemont Hospital Research Center, University of Montreal, Montreal, Quebec H1T 2M4, Canada
    J Biol Chem 285:6275-84. 2010
    b>Bleomycin is used in combination with other antineoplastic agents to effectively treat lymphomas, testicular carcinomas, and squamous cell carcinomas of the cervix, head, and neck...
  74. doi The role of all-trans retinoic acid in bleomycin-induced pulmonary fibrosis in mice
    Zhaoxing Dong
    Department of Respiratory, The 2nd Affiliated Hospital of Kunming Medical University, School of Pharmacy, Kunming Medical University, Kunming, Yunnan, China
    Exp Lung Res 38:82-9. 2012
    ..The objective of this study was to study the effect of ATRA on bleomycin-induced pulmonary fibrosis in mice and its possible mechanism...
  75. ncbi Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin
    T D Oury
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 25:164-9. 2001
    ..antioxidant porphyrin manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) could protect mice against bleomycin-induced lung fibrosis...
  76. ncbi Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy
    Marko Snoj
    Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia
    Tumori 95:398-402. 2009
    ..In addition, it was also found to have a vascular-disrupting effect. We report a case of limb-sparing treatment of bleeding melanoma recurrence by electrochemotherapy..
  77. pmc Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis
    Sumiko Adachi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Proc Natl Acad Sci U S A 108:10004-9. 2011
    ..Our results demonstrate that Arabidopsis undergoes a programmed endoreduplicative response to DSBs, suggesting that plants have evolved a distinct strategy to sustain growth under genotoxic stress...
  78. pmc Filamin-A as a marker and target for DNA damage based cancer therapy
    Jingyin Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, 195 Little Albany St, New Brunswick, NJ 08903, USA
    DNA Repair (Amst) 11:192-200. 2012
    ..We found that reduction of filamin-A sensitizes cancer cells to chemotherapy reagents bleomycin and cisplatin, delays the repair of not only DSBs but also single strand breaks (SSBs) and interstrand ..
  79. ncbi Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin's disease
    Volker Diehl
    First Department of Internal Medicine, University of Cologne, Cologne, Germany
    N Engl J Med 348:2386-95. 2003
    ..Faced with unsatisfactory results of treatment for advanced Hodgkin's disease, we investigated three combinations of chemotherapy...
  80. ncbi Possible role of apoptosis in the pathogenesis of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Tokyo Medical and Dental University School of Medicine, Department of Dermatology, Tokyo, Japan
    J Invest Dermatol 122:44-50. 2004
    ..examined the induction of apoptosis and expression of Fas, Fas ligand, as well as caspase-3 in a murine model of bleomycin-induced scleroderma. Dermal sclerosis was induced by local injections of bleomycin (1 mg per mL) in C3H/HeJ mice...
  81. ncbi Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children
    Hiroshi Takahashi
    Department of Neurosurgery, Nippon Medical School Dai ni Hospital, 1 396 Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa, 211 8533, Japan
    Childs Nerv Syst 21:701-4. 2005
    We first reported postoperative intratumoral chemotherapy with bleomycin for craniopharyngiomas in 1985. However, this local bleomycin chemotherapy has not yet been used very frequently...
  82. ncbi Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12
    Hye Ryun Kang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:7723-32. 2007
    ..Finally, they demonstrate that Bax, Bid, and MMP-12 play similar roles in bleomycin-induced fibrosis, thereby highlighting the importance of this Bid-activated, Bax-mediated pathway and downstream ..
  83. ncbi Results of treatment with doxorubicin, bleomycin, vinblastine and dacarbazine and highly active antiretroviral therapy in advanced stage, human immunodeficiency virus-related Hodgkin's lymphoma
    Blanca Xicoy
    Institut Català d Oncologia Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Haematologica 92:191-8. 2007
    Although doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is considered the standard chemotherapy regimen for Hodgkin's lymphoma (HL), information on the results of this therapy in human immunodeficiency (HIV)-related HL is ..
  84. pmc Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Immunol 185:2502-15. 2010
    Mice s.c. injected with bleomycin, an experimental model for human systemic sclerosis, develop skin and lung fibrosis, which is mediated by inflammatory cell infiltration...
  85. ncbi Consolidation radiation after complete remission in Hodgkin's disease following six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy: is there a need?
    S Laskar
    Department of Radiation Oncology, Tata Memorial Hospital, Dr Ernest Borges Marg, Parel 400 012, Mumbai, India
    J Clin Oncol 22:62-8. 2004
    ..the role of consolidation radiation in patients achieving a complete remission after six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy using event-free survival (EFS) and overall survival (OS) as ..
  86. ncbi An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis
    B Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Pathol 211:455-62. 2007
    ..showed significantly reduced fibrotic lesions and collagen deposition in the lung upon endotracheal injection of bleomycin. Further studies on the mechanisms by which C/EBPbeta regulates fibrosis indicated that knockout of C/EBPbeta ..
  87. pmc Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
    A Nakao
    Department of Medicine II, Chiba University, School of Medicine, Chiba 260 0856, Japan
    J Clin Invest 104:5-11. 1999
    ..we determined the effect of exogenous Smad7, introduced by a recombinant human type 5 adenovirus vector, on bleomycin-induced lung fibrosis in mice...
  88. ncbi Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury
    T Genovese
    Dept of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario, Via C Valeria, Gazzi, 98100 Messina, Italy
    Eur Respir J 25:225-34. 2005
    ..The aim of this study was to investigate the effect of rosiglitazone and 15d-PGJ2 on the lung injury caused by bleomycin administration. Mice subjected to intratracheal administration of bleomycin developed significant lung injury...
  89. pmc Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis
    James S Hagood
    Department of Pediatrics, University of Alabama, Birmingham, USA
    Am J Pathol 167:365-79. 2005
    ..accumulation of lung collagen, and increased TGF-beta activation in the lungs 14 days after intratracheal bleomycin. The majority of cells demonstrating TGF-beta activation and myofibroblast differentiation in bleomycin-induced ..
  90. pmc Complex regulation of pulmonary inflammation and fibrosis by CCL18
    Kerill Pochetuhen
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Pathol 171:428-37. 2007
    ..We hypothesized that in combination with bleomycin injury, overexpression of CCL18 will worsen the severity of lung inflammation and fibrosis...
  91. doi Bleomycin-based electrochemotherapy: clinical outcome from a single institution's experience with 52 patients
    Luca G Campana
    Department of Oncological and Surgical Sciences, Istituto di Clinica Chirurgica Generale II, Policlinico Universitario, 6 degrees Piano Via Giustiniani 2, 33128, Padova, Italy
    Ann Surg Oncol 16:191-9. 2009
    ..histotypes, mainly melanoma and breast cancer, with disease unsuitable for conventional treatments underwent bleomycin-based ECT for cutaneous and subcutaneous metastases...
  92. pmc Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma
    Minghua Wu
    Section of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA
    Am J Pathol 174:519-33. 2009
    ..Rosiglitazone attenuated bleomycin-induced skin inflammation and dermal fibrosis as well as subcutaneous lipoatrophy and counteracted the up-..
  93. doi Prominin-1/CD133+ lung epithelial progenitors protect from bleomycin-induced pulmonary fibrosis
    Davide Germano
    Experimental Critical Care Medicine, Department of Biomedicine, University of Basel, Basel, Switzerland
    Am J Respir Crit Care Med 179:939-49. 2009
    The mouse model of bleomycin-induced lung injury offers an approach to study idiopathic pulmonary fibrosis, a progressive interstitial lung disease with poor prognosis...
  94. pmc Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing
    Minghua Wu
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 E Huron St, Chicago, IL 60611, USA
    Am J Pathol 175:1041-55. 2009
    ..Using the model of bleomycin-induced scleroderma, we found that the early influx of inflammatory cells into the skin and lungs, and the ..
  95. doi Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis
    Mohit Kapoor
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 60:2822-9. 2009
    ..The aim of the present study was to examine the role of PPARgamma in a mouse model of skin scleroderma, in which mice bearing a fibroblast-specific deletion of PPARgamma were used...
  96. pmc Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4
    Dianhua Jiang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Invest 120:2049-57. 2010
    ..To investigate this issue, we used intratracheal instillation of bleomycin as a model of acute lung injury and fibrosis. We found that bleomycin treatment increased syndecan-4 expression...
  97. ncbi Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Am J Respir Cell Mol Biol 27:419-27. 2002
    ..In this study we demonstrate that IL-13 and C10 are elevated in the pathogenesis of bleomycin-induced pulmonary fibrosis...
  98. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
    ..of IL-13Ralpha(2) signaling led to marked downregulation of TGF-beta(1) production and collagen deposition in bleomycin-induced lung fibrosis...
  99. ncbi COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis
    Alysia Kern Lovgren
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599, USA
    Am J Physiol Lung Cell Mol Physiol 291:L144-56. 2006
    ..These findings suggest that prostacyclin analogs will protect against bleomycin-induced pulmonary fibrosis in COX-2(-/-) mice...
  100. ncbi Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse
    H Yasui
    Third Department of Internal Medicine, Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Mie Prefecture, Japan
    Am J Respir Crit Care Med 163:1660-8. 2001
    It is well recognized that activation of the coagulation system plays an important role in bleomycin (BLM)-induced lung injury and fibrosis. The protein C (PC) pathway is an important regulator of the coagulation system...
  101. ncbi Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation
    Anita Gothelf
    Department of Oncology, Rigshospitalet, University of, Copenhagen, Denmark
    Cancer Treat Rev 29:371-87. 2003
    ..A highly toxic molecule that does not usually pass the membrane barrier is the hydrophilic drug bleomycin. Once inside the cell, bleomycin acts as an enzyme creating single- and double-strand DMA-breaks...

Research Grants87

  1. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..non-psychotropic nanomolar CB1/ CB2 agonist is highly effective in preventing skin and lung fibrosis in a mouse bleomycin model of scleroderma and inhibits extracellular matrix production by dermal fibroblasts from patients with ..
  2. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..stress, which inhibit replication through different mechanisms than aphidicolin, and on ionizing radiation and bleomycin, which lead directly to DNA DSBs...
  3. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..that R-100 attenuates changes of pulmonary vascular and alveolar structure in a model of BPD induced by bleomycin treatment of neonatal rats...
  4. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..histocompatibility model of GVHD that also results in skin fibrosis as well as fibrosis of internal organs;and bleomycin injection that induces pulmonary fibrosis, we will test whether mice or cells lacking LIGHT, HVEM, or LT[..
  5. THEA NOREEN GOLDEN; Fiscal Year: 2015
    ..This proposal uses intratracheal bleomycin to model lung injury as it includes an inflammation and resolution phase...
  6. Robert Paine; Fiscal Year: 2016
    ..Insults, such as exposure to bleomycin, that result in pulmonary fibrosis are associated with decreased AEC expression of GM-CSF;fibrosis is reduced ..
  7. Bethany B Moore; Fiscal Year: 2016
    ..Additionally, we and other have demonstrated that periostin-/- mice are protected from bleomycin-induced fibrosis...
  8. ROBERT MATTHEW TIGHE; Fiscal Year: 2016
    ..CXCR3 null mice develop severe and progressive fibrosis following treatment with intratracheal bleomycin relative to wild type control mice...
  9. Yvonne M W Janssen-Heininger; Fiscal Year: 2016
    ..JNK1-/-) fail to induce mesenchymal genes or develop fibrosis in response to ovalbumin, TGF-[unreadable]1, or bleomycin;3) TGF-[unreadable]1-induced EMT requires JNK1, through JNK1-dependent phosphorylation of SMAD3 in the linker ..
  10. Irina G Luzina; Fiscal Year: 2016
    ..Determine whether partial neutralization of bleomycin-induced collagen accumulation by CCL18 overexpression is dependent on de- creased expression of 1V-containing ..
  11. Host Factors in Fungal Allergy and Fibrosis
    Anuradha Ray; Fiscal Year: 2010
    ..the role of KGF and the ligands for CXCR3 (CXCL9, CXCL10, and CXCL11) in regulating the fibrotic response to bleomycin lung injury in rodents...
  12. Bruce Neil Cronstein; Fiscal Year: 2016
    ..the development of hypertrophic scarring in a model of dermal scarring and diffuse dermal fibrosis induced by bleomycin treatment in wild type, adenosine A1, A2A, A2B and A3 receptor knockout mice, mice that generate less ..
  13. LUIS ALBERTO ORTIZ; Fiscal Year: 2016
    ..and treatment of fibrotic lung disease and RV failure in established integrated models of lung injury (bleomycin-induced) and RV failure independent of injury in the pulmonary circulation (PA banding;PAB) and 2) characterize ..
  14. Shulin Li; Fiscal Year: 2014
    ..Intratumoral injection of bleomycin via electroporation has proven very effective in treating highly malignant SCC tumors of the head and neck in a ..
  15. Andrew M Tager; Fiscal Year: 2015
    ..mediator sphingosine 1-phosphate (S1P) protects against the development of pulmonary fibrosis in mice induced by bleomycin lung injury...
  16. ISELA CARIDAD VALERA; Fiscal Year: 2016
    ..SSc is more common in women than in men;however men experience an accelerated disease with reduced survival. Bleomycin-induced lung fibrosis is also more severe in male mice than in females...
  17. Lisa R Young; Fiscal Year: 2016
    ..II cell apoptosis, excess monocyte-chemotactic protein-1 (MCP-1) secretion, AM activation, and susceptibility to bleomycin-induced fibrosis...
  18. BENJAMIN DOUGLAS KORMAN; Fiscal Year: 2014
    ..I first plan to investigate whether adipocyte PPAR-gamma gain of function can prevent fibrosis by applying the bleomycin-induced skin fibrosis model of SSc to transgenic mice with either constitutively activated PPAR-gamma or loss of ..
  19. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..aims are proposed: 1) characterize the elaboration of eotaxin and related CC chemokines in a rodent model of bleomycin-induced pulmonary fibrosis and identify the cells responsible for elaboration of injury-induced chemokines, and ..
  20. Elena Tourkina; Fiscal Year: 2016
    ..In vivo in the mouse bleomycin model system, CSD inhibits fibrosis, the overexpression of CXCR4 by monocytes, and monocyte and fibrocyte ..
  21. ABCA3 and the Response to Lung Injury
    Rashmin C Savani; Fiscal Year: 2012
    ..will provide a model of human disease, and that heterozygous and mutant ABCA3 mice will be more susceptible to bleomycin- and hyperoxia-induced lung injury...
  22. Genetic and Epigenetic Biomarkers for SCC of the Lung
    Steven A Belinsky; Fiscal Year: 2012
    ..aberrations formed following exposure to carcinogens that induce either single- (BPDE1) or double-strand breaks (bleomycin) in DNA...
  23. FRANK JOSEPH JACONO; Fiscal Year: 2015
    ..Well established and validated rodent models of lung injury (bleomycin-instillation and high tidal volume ventilation) will be used...
  24. Anthony J Baker; Fiscal Year: 2016
    ..We will study the RV-specific model of bleomycin-induced pulmonary fibrosis, which leads to pulmonary hypertension and RV failure. Aim 1...
  25. Jeffrey C Horowitz; Fiscal Year: 2015
    ..FAK is increased in fibrotic lungs, and inhibition of FAK attenuates bleomycin-induced fibrosis in mice...
  26. Novel therapeutic for Alcoholic Liver Disease
    Bert Oehlen; Fiscal Year: 2009
    ..g. generated mice with a fibroblast specific deletion of Rac1, and showed that such mice are resistant to bleomycin-induced skin fibrosis...
  27. Inhibitor of differentiation-1 mediates antifibrotic effects of carbon monoxide
    ERIN DANIELLE MORSE; Fiscal Year: 2012
    ..studies that heme oxygenase-1 (HO-1) and its enzymatic product, carbon monoxide (CO), provide protection against bleomycin-induced lung fibrosis...
  28. Apoptosis and Fibrosis
    ARIEL R JOHNSON; Fiscal Year: 2013
    ..In renal, hepatic, and bleomycin-induced fibrosis, potent paracrine signaling factors secreted by apoptotic ECs have been identified...
  29. Urokinase plasminogen activator receptor associated protein and acute lung injury
    Michael Bundesmann; Fiscal Year: 2010
    ..expression in the lung, we hypothesized that uPARAP -/- mice will have greater fibrosis following intra-tracheal bleomycin instillation...
  30. Ming Hui Fan; Fiscal Year: 2014
    ..wildtype in two pulmonary fibrosis models-thoracic irradiation and intratracheal bleomycin-establishing a protective role for FAP in the pathogenesis of the disease...
  31. Manu Jain; Fiscal Year: 2016
    ..have been shown to prevent the development of fibrosis following the intratracheal administration of bleomycin, a commonly used model for the study of lung fibrosis...
  32. Development of a Novel TGF-beta Antagonist for Treating Hepatic Fibrosis
    Jung S Huang; Fiscal Year: 2010
    ..has excellent solubility, a long plasma half-life and a potent antagonist activity, effectively ameliorates bleomycin-induced lung fibrosis in mice...
  33. Methionine Aminopeptidase 2 in Pulmonary Fibrosis
    DANIEL J KASS; Fiscal Year: 2012
    ..To study the role of MetAP2 in pulmonary fibrosis, fumagillin, a specific inhibitor of MetAP2, was tested in the bleomycin model of pulmonary fibrosis in mice...
  34. Timothy S Blackwell; Fiscal Year: 2015
    ..However, treating these mice with low dose bleomycin results in a marked exacerbation of lung fibrosis as well as increased apoptosis of AECs and increased ..
  35. William E Lawson; Fiscal Year: 2016
    ..Our preliminar data reveal that SHH expression is upregulated in the lung with bleomycin induced lung injury and fibrosis...
  36. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2011
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  37. Thomas R Hoye; Fiscal Year: 2014
    ..each of the following either is a natural product itself or is directly derived from one: actinomycin, bleomycin, doxorubicin/daunorubicin/darubici/valrubicin (from daunomycin), etoposide/teniposide (from podophyllotoxin), ..
  38. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2010
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  39. Jesse Roman; Fiscal Year: 2016
    ..We also found that lung repair mechanisms appeared to be impaired after bleomycin-induced lung injury in the setting of chronic exposure to nicotine...
  40. Erica L Herzog; Fiscal Year: 2016
    ..inhibition of M2 macrophage differentiation is ameliorative in models of pulmonary fibrosis caused by either bleomycin inhalation or inducible lung targeted TGF-[unreadable]1 overexpression...
  41. Aging related susceptibility to lung injury - remodeling and oxidative stress
    Jesse Roman; Fiscal Year: 2012
    ..Importantly, when exposed to bleomycin, elderly animals show greater fibrosis as demonstrated histologically and by quantification of hydroxyproline...
  42. William E Lawson; Fiscal Year: 2015
    ..Preliminary data reveal that AEC deletion of [unreadable]-catenin leads to greater lung injury and fibrosis post bleomycin. In contrast, AEC deletion of the major receptor for TGF[unreadable] (TGF[unreadable]R2) attenuates lung ..
  43. Scanning Correlation Microscopy Methods for Quantifying DNA Repair Kinetics
    Georgios Alexandrakis; Fiscal Year: 2012
    ..kinase catalytic subunit (DNA-PKCS), in its wild type and repair-deficient 7A forms after exposure to 3-rays and bleomycin that are both double strand break forming agents...
  44. Rho-Kinase Pathway in Pulmonary Fibrosis
    Victor J Thannickal; Fiscal Year: 2012
    ..inhibit ROCK activity mediate anti-fibrotic effects when the drug is administered during the fibrotic phase of bleomycin-induced lung injury in mice...
  45. DOMINIQUE PASCAL FRUEH; Fiscal Year: 2016
    ..pathogens and often are valuable therapeutics, including antibiotics (penicillin, bacitracin), antitumor agents (bleomycin, epothilone), and immunosuppressants (rapamycin)...
  46. Regulating fibrocyte differentiation in fibrosis
    Richard H Gomer; Fiscal Year: 2009
    ..Injections of SAP prevent bleomycin-induced lung fibrosis in rats and mice, and ischemia-reperfusion induced cardiac fibrosis in mice...
  47. The Role of Plexin C1 in Scleroderma Related Interstitial Lung Disease
    Aditi Mathur; Fiscal Year: 2013
    ..Our preliminary data shows that Plexin C1 expression is increased in both the bleomycin exposed murine lung and the TGF-[unreadable]1 transgenic lung specific murine model...
  48. Prostanoids, Plasminogen Actication, and Personalized Therapeutics in IPF
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..In addition, the ability of these same regimens to ameliorate bleomycin-induced pulmonary fibrosis in mice will be assessed...
  49. Ivan O Rosas; Fiscal Year: 2014
    ..observations and preliminary studies that low concentration inhaled CO provides protection in a murine model of bleomycin-induced lung fibrosis by targeting multiple molecular pathways relevant to the pathogenesis of IPF...
  50. Neelam Azad; Fiscal Year: 2015
    ..proposal is to investigate the contribution of oxidative stress-regulated angiogenesis in the pathogenesis of bleomycin (BLM)-induced pulmonary fibrosis...
  51. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2009
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke...
  52. Satish K Madala; Fiscal Year: 2015
    ..data from our laboratory show elevated expression of IL-31, IL-31RA and OSMR[unreadable] in skin lesions of bleomycin-induced SSc...
  53. Predicting pancreatic cancer responses for a Parp inhibitor-based clinical trial
    Michael G Goggins; Fiscal Year: 2010
    ..patients to a low-dose DNA strand break regimen of monthly cycles of chemotherapy (irinotecan, cisplatin, bleomycin and mitomycin C) with or without the oral Parp inhibitor, olarparib...
  54. Inhibition of the SDF-1/CXCR4 axis as preventive therapy for radiation-induced pu
    HUI KUO contact SHU; Fiscal Year: 2010
    ..In mouse models of bleomycin-induced pulmonary fibrosis, inhibitors of CXCR4 can significantly decrease the development of lung fibrosis...
  55. Mfge8 and the Role of Apoptotic Cell Clearance in Lung Injury
    Kamran Atabai; Fiscal Year: 2011
    ..Atabai has found that mice lacking functional MfgeS develop exaggerated pulmonary fibrosis after intratracheal bleomycin administration. Bleomycin induces epithelial cell apoptosis, inflammation and pulmonary fibrosis. Dr...
  56. John K McGuire; Fiscal Year: 2014
    ..In mice with ALI induced by Pseudomonas aeruginosa infection or bleomycin toxicity, mice lacking CD103 showed delayed resolution of neutrophilic inflammation and had higher mortality ..
  57. Andrew J Gow; Fiscal Year: 2016
    ..of iNOS and the SNO-degrading enzyme, GSNOR, in resident and recruited macrophages alters the outcome of bleomycin-mediated lung injury...
  58. In Vivo and In Vitro Characterization of Bronchio-Alveolar Stem Cells
    CARLA F KIM; Fiscal Year: 2010
    ..lung injury on BASC functions including self-renewal, differentiation, and gene expression using naphthalene and bleomycin treatment. Completion of the proposed studies will establish a functional assay for lung stem cells...
  59. A mouse model enabling in vivo labeling of fibroblast-specific transcription duri
    Richard A Steinman; Fiscal Year: 2012
    ..mouse model will be validated by demonstrating fibroblast reprogramming in response to the profibrotic agent bleomycin. We aim to: 1...
  60. Barry S Shea; Fiscal Year: 2015
    ..that antagonism of the S1P receptor, S1P1, dramatically worsened pulmonary vascular leak and fibrosis after bleomycin challenge in mice...
  61. SERUM AMYLOID P AND DERMAL WOUND FIBROSIS
    OLUYINKA OLUROTIMI OLUTOYE; Fiscal Year: 2010
    ..In vivo, systemic administration of SAP reduced fibrosis in rat and mouse models of bleomycin-induced pulmonary fibrosis and in a murine ischemia-reperfusion model of cardiac fibrosis...
  62. Kamran Atabai; Fiscal Year: 2015
    ..Mice deficient in Mfge8 develop an exaggerated fibrotic response to bleomycin injury due to an in vivo defect in collagen degradation...
  63. BIOPHYSICAL AND SCANNING FORCE MICROSCOPY STUDIES
    DOROTHY ERIE; Fiscal Year: 2001
    ..of the amino groups on the bases; while, oxidative damage by ionizing radiation or treatment with agents such as bleomycin leads to abasic sites and to strand scission, resulting in blocked 3'termini...
  64. LUNG TOXIC INTERACTIONS INVOLVING THERAPEUTIC DRUGS
    JAMES KEHRER; Fiscal Year: 1991
    ..b>Bleomycin and cyclophosphamide (CP) will be used since they have been used clinically in combination and each has been ..
  65. Hyaluronan and its Receptors in BPD
    RASHMIN SAVANI; Fiscal Year: 2006
    ..Data from our laboratory, using the rodent model of bleomycin-induced lung injury, indicates increased lung HA in association with macrophage accumulation...
  66. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..This assay has been expanded by replacing the initial test mutagen bleomycin with 4- nitroquinoline-1-oxide (4-NQO, a ultraviolet light (UV) mimetic agent), gamma-radiation, and benzo(alpha)..
  67. Origin of the Dermal Fibroblast
    Stephen Clark; Fiscal Year: 2006
    ..Following the induction of fibrotic lesions by daily injections of bleomycin, skin samples from both members of the parabiotic pair will be evaluated for GFP expression...
  68. Interferon-gamma regulation of bleomycin pulmonary toxicity
    Edward Chen; Fiscal Year: 2007
    The genetic and immunologic basis of pulmonary fibrosis is poorly understood. In rodents, intratracheal bleomycin induces rapidly progressive inflammation similar to human organizing diffuse alveolar damage (DAD), with sub-acute lung ..
  69. MUTAGEN SENSITIVITY & PROGRESSION IN BARRETTS ESOPHAGUS
    DIANA FARROW; Fiscal Year: 1999
    ..study is to determine whether chromosomal instability, as measured in vitro in cultured lymphocytes by the bleomycin sensitivity assay, or in vivo as allelic losses on specific chromosomes, predicts neoplastic progression among ..
  70. CYCLOMETALLATED DNA NUCLEASES
    JOHN SUGGS; Fiscal Year: 1990
    Numerous transition metal complexes have been used as drugs, especially as anti-cancer agents Cisplatin and bleomycin are two examples of drugs which contain a transition metal (platinum and iron, respectively) and both of these are ..
  71. The LPA Pathway in Lung Fibrosis: Novel Mediators and New Therapeutic Targets
    Andrew M Tager; Fiscal Year: 2010
    ..lysophosphatidic acid (LPA) is critically required for the development of pulmonary fibrosis in mice following bleomycin-induced lung injury...
  72. BIOSYNTHESIS OF PEPTIDE/POLYKETIDE DERIVED ANTIBIOTICS
    Ben Shen; Fiscal Year: 2001
    ....
  73. Metabolism and Detoxification of Base Propenals
    Sanjay Srivastava; Fiscal Year: 2007
    ..High concentrations of BPs are generated by anticancer drugs such as bleomycin and environmental agents such as Cr (VI)...