glycoconjugates

Summary

Summary: Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)

Top Publications

  1. ncbi Volatile compounds released by enzymatic hydrolysis of glycoconjugates of leaves and grape berries from Vitis vinifera Muscat of Alexandria and Shiraz cultivars
    J Wirth
    , IPV-ENSAM-INRA, 2 place Viala, 34060 Montpellier Cedex 1, France
    J Agric Food Chem 49:2917-23. 2001
  2. pmc Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow
    Alexander Zarbock
    Department of Anesthesiology and Intensive Care Medicine, University of Münster and Max Planck Institute, Germany
    Blood 118:6743-51. 2011
  3. pmc Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis
    Devinder Kaur
    Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523 1682, USA
    Adv Appl Microbiol 69:23-78. 2009
  4. pmc Growth of Streptococcus pneumoniae on human glycoconjugates is dependent upon the sequential activity of bacterial exoglycosidases
    Amanda M Burnaugh
    Center for Microbial Pathogenesis, Research Institute at Nationwide Children s Hospital, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio 43205 2696, USA
    J Bacteriol 190:221-30. 2008
  5. ncbi Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs
    Nao Yamakawa
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
    Biochimie 89:1396-408. 2007
  6. pmc Density variant glycan microarray for evaluating cross-linking of mucin-like glycoconjugates by lectins
    Kamil Godula
    Department of Chemistry, University of California, Berkeley, California 94720, United States
    J Am Chem Soc 134:15732-42. 2012
  7. ncbi Meaning and therapeutic potential of microbial recognition of host glycoconjugates
    K A Karlsson
    Institute of Medical Biochemistry, Goteborg University, Sweden
    Mol Microbiol 29:1-11. 1998
  8. ncbi Microbial recognition of human cell surface glycoconjugates
    Anne Imberty
    CERMAV CNRS UPR5301, affiliated with Université Joseph Fourier and belonging to ICMG, BP53, F38041 Grenoble Cedex 9, France
    Curr Opin Struct Biol 18:567-76. 2008
  9. pmc Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    Jafar Mahdavi
    Department of Odontology Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 297:573-8. 2002
  10. pmc Coxsackievirus A24 variant uses sialic acid-containing O-linked glycoconjugates as cellular receptors on human ocular cells
    Nitesh Mistry
    Division of Virology, Department of Clinical Microbiology, Umea University, SE 90185 Umeå, Sweden
    J Virol 85:11283-90. 2011

Detail Information

Publications330 found, 100 shown here

  1. ncbi Volatile compounds released by enzymatic hydrolysis of glycoconjugates of leaves and grape berries from Vitis vinifera Muscat of Alexandria and Shiraz cultivars
    J Wirth
    , IPV-ENSAM-INRA, 2 place Viala, 34060 Montpellier Cedex 1, France
    J Agric Food Chem 49:2917-23. 2001
    b>Glycoconjugates from Muscat of Alexandria and Shiraz leaves and grape berries were isolated by adsorption on Amberlite XAD-2 resin, and enzymatically released aglycons were analyzed by GC-FID and GC-MS...
  2. pmc Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow
    Alexander Zarbock
    Department of Anesthesiology and Intensive Care Medicine, University of Münster and Max Planck Institute, Germany
    Blood 118:6743-51. 2011
    Reversible interactions of glycoconjugates on leukocytes with P- and E-selectin on endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the first step in their recruitment to sites of injury...
  3. pmc Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis
    Devinder Kaur
    Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523 1682, USA
    Adv Appl Microbiol 69:23-78. 2009
    ..In this review, the laboratory personnel who have been the focal point of some to these developments review recent progress towards a comprehensive understanding of the basic physiology and functions of the cell wall of M. tuberculosis...
  4. pmc Growth of Streptococcus pneumoniae on human glycoconjugates is dependent upon the sequential activity of bacterial exoglycosidases
    Amanda M Burnaugh
    Center for Microbial Pathogenesis, Research Institute at Nationwide Children s Hospital, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio 43205 2696, USA
    J Bacteriol 190:221-30. 2008
    In the human host, Streptococcus pneumoniae encounters a variety of glycoconjugates, including mucin, host defense molecules, and glycans associated with the epithelial surface. S...
  5. ncbi Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs
    Nao Yamakawa
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
    Biochimie 89:1396-408. 2007
    ..Finally, using the fluorometric HPLC and monoclonal antibodies, we demonstrated that glycoconjugates from sea urchin sperm exclusively contained Neu5Ac8S, whereas those from eggs contained Neu5Gc8S...
  6. pmc Density variant glycan microarray for evaluating cross-linking of mucin-like glycoconjugates by lectins
    Kamil Godula
    Department of Chemistry, University of California, Berkeley, California 94720, United States
    J Am Chem Soc 134:15732-42. 2012
    ..possess the ability to agglutinate A(1)-blood cells carrying the α-GalNAc epitope and cross-link low valency glycoconjugates, only SBA showed a tendency to form intermolecular cross-links among the arrayed polyvalent mucin mimetics...
  7. ncbi Meaning and therapeutic potential of microbial recognition of host glycoconjugates
    K A Karlsson
    Institute of Medical Biochemistry, Goteborg University, Sweden
    Mol Microbiol 29:1-11. 1998
    ..Most of the known host receptors for microbes are glycoconjugates, and the diversity and selectivity of host tissue glycosylation allow for the tropism of infections...
  8. ncbi Microbial recognition of human cell surface glycoconjugates
    Anne Imberty
    CERMAV CNRS UPR5301, affiliated with Université Joseph Fourier and belonging to ICMG, BP53, F38041 Grenoble Cedex 9, France
    Curr Opin Struct Biol 18:567-76. 2008
    ..microorganisms often use sugar-binding proteins, that is lectins and adhesins, to recognize and bind to host glycoconjugates where sialylated and fucosylated oligosaccharides are the major targets...
  9. pmc Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    Jafar Mahdavi
    Department of Odontology Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 297:573-8. 2002
    ..The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of ..
  10. pmc Coxsackievirus A24 variant uses sialic acid-containing O-linked glycoconjugates as cellular receptors on human ocular cells
    Nitesh Mistry
    Division of Virology, Department of Clinical Microbiology, Umea University, SE 90185 Umeå, Sweden
    J Virol 85:11283-90. 2011
    ..Previously it has been suggested that CVA24v uses sialic acid-containing glycoconjugates as attachment receptors on corneal cells, but the nature of these receptors is poorly described...
  11. pmc Rice Os9BGlu31 is a transglucosidase with the capacity to equilibrate phenylpropanoid, flavonoid, and phytohormone glycoconjugates
    Sukanya Luang
    Institute of Science, Schools of Biochemistry and Chemistry, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    J Biol Chem 288:10111-23. 2013
    ....
  12. ncbi Identification and characterization of binding properties of Helicobacter pylori by glycoconjugate arrays
    Anke Walz
    Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, D 93053 Regensburg, Germany
    Glycobiology 15:700-8. 2005
    ..The results demonstrate that the bacterial overlay method on glycoconjugate arrays is a useful tool for exploration and the characterization of unknown adhesin specificities of H. pylori and other bacteria...
  13. pmc Glycoconjugates play a key role in Campylobacter jejuni Infection: interactions between host and pathogen
    Christopher James Day
    Institute for Glycomics, Griffith University, Gold Coast QLD, Australia
    Front Cell Infect Microbiol 2:9. 2012
    ..for studying the role of glycans in host-pathogen interactions, as well as the role of bacterial surface glycoconjugates in infection. Using glycan array analysis, C...
  14. ncbi Natural glycoconjugates with antitumor activity
    Barbara La Ferla
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I 20126, Milano, Italy
    Nat Prod Rep 28:630-48. 2011
    ..In this review we focus our attention on natural glycoconjugates with anticancer properties...
  15. ncbi Multivalent glycoconjugates as anti-pathogenic agents
    Anna Bernardi
    Universita di Milano, Dipartimento di Chimica Organica e Industriale and Centro di Eccellenza CISI, via Venezian 21, 20133 Milano, Italy
    Chem Soc Rev 42:4709-27. 2013
    ..Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-..
  16. pmc Differential release and phagocytosis of tegument glycoconjugates in neurocysticercosis: implications for immune evasion strategies
    Jorge I Alvarez
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    PLoS Negl Trop Dis 2:e218. 2008
    ..exhibit humoral responses against carbohydrate-based antigens, and the tegument is known to be rich in glycoconjugates (GCs), the expression of these types of molecules was analyzed in human, porcine, and murine NCC specimens...
  17. ncbi Syntheses and some applications of chemically defined multivalent glycoconjugates
    R Roy
    Department of Chemistry, University of Ottawa, Ontario, Canada
    Curr Opin Struct Biol 6:692-702. 1996
    ..Novel dendritic carbohydrate structures are emerging as potent ligands for carbohydrate-binding proteins...
  18. pmc Enterovirus 70 binds to different glycoconjugates containing alpha2,3-linked sialic acid on different cell lines
    M Reza Nokhbeh
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada K1H 8M5
    J Virol 79:7087-94. 2005
    ....
  19. ncbi Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1/2 and results in enhanced production of specific cytokines
    Nicholas M Stamatos
    Institute of Human Virology, Department of Medicine, University of Maryland Medical Center, University of Maryland, Baltimore, MD 21201, USA
    J Leukoc Biol 75:307-13. 2004
    ..The role of sialidase(s) and the consequent desialylation of cell surface glycoconjugates in the activation of monocytes have not been established...
  20. ncbi The apical membrane of intestinal brush cells possesses a specialised, but species-specific, composition of glycoconjugates--on-section and in vivo lectin labelling in rats, guinea-pigs and mice
    A Gebert
    Abteilung Anatomie 2, Medizinische Hochschule Hannover, Germany
    Histochem Cell Biol 113:389-99. 2000
    ..To characterise glycoconjugates possibly involved in a sensory function, we investigated brush cells in the small intestine of three species ..
  21. pmc ABC transporters involved in export of cell surface glycoconjugates
    Leslie Cuthbertson
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
    Microbiol Mol Biol Rev 74:341-62. 2010
    Complex glycoconjugates play critical roles in the biology of microorganisms. Despite the remarkable diversity in glycan structures and the bacteria that produce them, conserved themes are evident in the biosynthesis-export pathways...
  22. pmc The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces
    Anna Helander
    GI Cell Biology Laboratory, Enders 1220, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Virol 77:7964-77. 2003
    ..binding of type 1 reoviruses to M cells in vivo involves interaction of the type 1 sigma1 protein with glycoconjugates containing alpha2-3-linked sialic acid that are accessible to viral particles only on M cell apical surfaces.
  23. ncbi Preparation, characterization and immunogenicity of HIV-1 related high-mannose oligosaccharides-CRM197 glycoconjugates
    Anna Kabanova
    Novartis Vaccines and Diagnostics, Research Center, Via Fiorentina 1, 53100, Siena, Italy
    Glycoconj J 27:501-13. 2010
    ..We conclude that further structural vaccinology work is needed to identify an antigen presentation that closely matches in vivo the structure of the epitope mapped by 2G12...
  24. ncbi Sulfated glycoconjugates are powerful modulators of bovine sperm adhesion and release from the oviductal epithelium in vitro
    R Talevi
    Dipartimento di Biologia Evolutiva e Comparata, Universita di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    Biol Reprod 64:491-8. 2001
    ..Results showed that 1) all sulfated glycoconjugates were powerful inhibitors of sperm binding to oviductal monolayers in a dose-dependent manner, whereas N-..
  25. ncbi Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update covering the period 1999-2000
    David J Harvey
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford OX1 3QU, United Kingdom
    Mass Spectrom Rev 25:595-662. 2006
    ..matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates and continues coverage of the field from the previous review published in 1999 (D. J...
  26. ncbi Inhibition of Helicobacter pylori infection by bovine milk glycoconjugates in a BAlb/cA mouse model
    X Wang
    Department of Infectious Diseases and Medical Microbiology, University of Lund, Sweden
    J Med Microbiol 50:430-5. 2001
    ..pylori sialic acid-specific haemagglutination. This study explored whether sialylated glycoconjugates from bovine milk could inhibit an experimental H. pylori infection in a mouse model...
  27. ncbi Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates
    Hisashi Ashida
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    Glycobiology 19:1010-7. 2009
    ..However, the enzyme did not act on glycoconjugates containing alpha1,2-fucosyl residue or on synthetic alpha-fucoside (p-nitrophenyl-alpha-l-fucoside)...
  28. ncbi Catabolism of salivary glycoconjugates in acute ethanol intoxication
    Napoleon Waszkiewicz
    Department of Psychiatry, Medical University of Bialystok, Bialystok, Poland
    Med Sci Monit 15:CR413-7. 2009
    ..0 g/kg of body weight, as 40% vodka) on the specific activities of alpha-mannosidase, alpha-fucosidase, beta-glucuronidase, and beta-galactosidase as well as on the total protein concentration in saliva in eight healthy young volunteers...
  29. ncbi Specificity of human anti-carbohydrate IgG antibodies as probed with polyacrylamide-based glycoconjugates
    E P Smorodin
    Institute of Experimental and Clinical Medicine, Hiiu 42, 11619 Tallinn, Estonia
    Glycoconj J 20:83-9. 2004
    ..Antibodies to these glycotopes were found in human serum. A set of polyacrylamide (PAA)--based glycoconjugates was applied to the direct and competitive enzyme-linked immunosorbent assays (ELISA) to characterize the ..
  30. ncbi Evaluation of different alpha-Galactosyl glycoconjugates for use in xenotransplantation
    Guerard W Byrne
    Nextran Inc, 303B College Road, Princeton, New Jersey, USA
    Bioconjug Chem 13:571-81. 2002
    ..to block anti-Gal IgG and IgM binding was determined using a competition ELISA assay on defined HSA-Gal glycoconjugates and porcine microvascular endothelial cell substrates...
  31. ncbi Possible contribution of beta-glycosidases and caspases in the cytotoxicity of novel glycoconjugates in colon cancer cells
    Hossam M M Arafa
    Department of Pharmacol and Toxicol, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Invest New Drugs 28:306-17. 2010
    b>Glycoconjugates represent a recent trend in cancer chemotherapy that adopts the concept of selective prodrug/drug targeting of tumor cells by selectively binding to specific transmembrane glucose transporters...
  32. ncbi Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase--a way to new glycodrugs and materials
    Pavla Bojarová
    Institute of Microbiology, Center for Biocatalysis and Biotransformation, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Glycobiology 19:509-17. 2009
    ..A synthetic bivalent tethered di-LacdiNAc is the best currently known precipitation agent for both of these receptors and has promising potential for the development of immunoactive glycodrugs...
  33. pmc Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
    Tsui Ling Hsu
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:2614-9. 2007
    ..Metabolic oligosaccharide engineering, which inserts sugar-reporting groups into cellular glycoconjugates, represents a powerful method for imaging the localization, trafficking, and dynamics of glycans and ..
  34. ncbi C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates
    Karlijn Gijzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Curr Protein Pept Sci 7:283-94. 2006
    ..When CLRs bind endogenous glycosylated ligands they mediate several processes like cell-cell adhesion and clearance of aberrant cells like tumor cells or apoptotic cells...
  35. ncbi Bacterial cell-envelope glycoconjugates
    Paul Messner
    Department of Nanobiotechnology, NanoGlycobiology Unit, University of Natural Resources and Life Sciences, Vienna, Austria
    Adv Carbohydr Chem Biochem 69:209-72. 2013
    ..function, genetic basis, biosynthesis, and biomedical and biotechnological applications of cell-envelope glycoconjugates, S-layer glycoprotein glycans, and "nonclassical" secondary-cell wall polysaccharides...
  36. pmc Preparation of glycoconjugates by dialkyl squarate chemistry revisited
    Shu jie Hou
    NIDDK, LBC, National Institutes of Health, Bethesda, MD 20892 0815, USA
    Carbohydr Res 343:196-210. 2008
    ..Nevertheless, dimethyl squarate seemed to be the most convenient reagent because it is a crystalline, easy to handle, and commercially available material with very good reactivity...
  37. pmc Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions
    Xinghai Ning
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Angew Chem Int Ed Engl 47:2253-5. 2008
  38. ncbi Oligosaccharides and glycoconjugates in bovine milk and colostrum
    P K Gopal
    New Zealand Dairy Research Institute, Massey University, Palmerston North, New Zealand
    Br J Nutr 84:S69-74. 2000
    Oligosaccharides and glycoconjugates are some of the most important bioactive components in milk. A great deal of information is available on the biological function of the components from human milk...
  39. ncbi Beta-galactofuranoside glycoconjugates on conidia and conidiophores of Aspergillus niger
    G L Wallis
    School of Life and Environmental Sciences, The University of Nottingham, UK
    FEMS Microbiol Lett 201:21-7. 2001
    ..Galactofuranoic (Galf)-containing glycoconjugates that occur in organisms pathogenic or allergenic to man are frequently antigenic and immunodominant...
  40. ncbi Differences between Naegleria fowleri and Naegleria gruberi in expression of mannose and fucose glycoconjugates
    Isaac Cervantes-Sandoval
    Department of Infectomic and Molecular Pathogenesis, Center for Research and Advanced Studies, National Polytechnic Institute, Av IPN 2508, Mexico City 07360, Mexico
    Parasitol Res 106:695-701. 2010
    ..fowleri with their target cells. In the present study, we investigated the composition of glycoconjugates present on the surface of trophozoites of the pathogenic N. fowleri and the nonpathogenic Naegleria gruberi...
  41. ncbi Glycoconjugates in the detection of alcohol abuse
    Napoleon Waszkiewicz
    Department of Psychiatry, Medical University of Białystok, ul Plac Brodowicza 1, 16 070 Choroszcz, Poland
    Biochem Soc Trans 39:365-9. 2011
    ..g. after trauma). In clinical practice, glycoconjugate markers of alcohol use/abuse let us distinguish alcoholic from non-alcoholic tissue damage, having important implications for the treatment and management of diseases...
  42. pmc Sustained protection in mice immunized with fractional doses of Salmonella Enteritidis core and O polysaccharide-flagellin glycoconjugates
    Raphael Simon
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e64680. 2013
    ..These results provide important insights regarding the potency of Salmonella glycoconjugate vaccines that use flagellin as a carrier protein...
  43. ncbi Anticancer effects of novel photodynamic therapy with glycoconjugated chlorin for gastric and colon cancer
    Mamoru Tanaka
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Anticancer Res 31:763-9. 2011
    ..Cancer cells consume more glucose than normal cells. In this study, the efficacy of PDT using a newly developed photosensitizer, glycoconjugated chlorin (H2TFPC-SGlc), was compared with Talaporfin, which is clinically used in Japan...
  44. ncbi Self-assembly of amphiphilic glycoconjugates into lectin-adhesive nanoparticles
    Alexandre G Dal Bó
    Centre de Recherches sur les Macromolecules Vegetales CERMAV CNRS, BP 53, F 38041 Grenoble Cedex 9, France
    Langmuir 28:1418-26. 2012
    ....
  45. ncbi Glycoconjugates in New World species of Leishmania: polymorphisms in lipophosphoglycan and glycoinositolphospholipids and interaction with hosts
    Rafael Ramiro de Assis
    Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, FIOCRUZ, Av Augusto de Lima, 1715, Belo Horizonte, MG 30190 002, Brazil
    Biochim Biophys Acta 1820:1354-65. 2012
    ..Amongst the many surface molecules of Leishmania, the glycoconjugates are known to play a central role in host-parasite interactions and are the focus of this review.
  46. ncbi Glycoconjugates and polysaccharides from the Scedosporium/Pseudallescheria boydii complex: structural characterisation, involvement in cell differentiation, cell recognition and virulence
    Livia Cristina L Lopes
    Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Brasil
    Mycoses 54:28-36. 2011
    ..These glycosylated polymers, being present in the fungal cell wall, are mostly absent from mammalian cells, and are excellent targets for the design of new agents capable of inhibiting fungal growth and differentiation of pathogens...
  47. ncbi Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging
    D Ilver
    Department of Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 279:373-7. 1998
    ..pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori...
  48. pmc Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes
    H M Muller
    Istituto di Parassitologia, Universita di Roma, La Sapienza, P A Moro, Italy
    EMBO J 12:2881-9. 1993
    ..This amino acid motif confers on the CS protein the ability to bind specifically to sulfated glycoconjugates and to hepatocytes...
  49. ncbi Carbohydrate profiling of fungal cell wall surface glycoconjugates of Trichophyton tonsurans and other keratinophilic filamentous fungi using lectins
    André Ferraz Goiana Leal
    Department of Mycology, Federal University of Pernambuco, Recife, PE, Brazil
    Mycoses 54:e789-94. 2011
    Various researchers have concluded that lectins are useful reagents for the study of fungal cell wall surface glycoconjugates. In this study, we evaluated the expression of N-acetyl-D-glucosamine, L-fucose, D-galactose and glucose/..
  50. ncbi Cell surface glycoconjugates and the extracellular matrix of the developing mouse embryo epicardium
    F Kalman
    Department of Pathology, Postgraduate Medical University, Budapest, Hungary
    Anat Embryol (Berl) 191:451-64. 1995
    Cell surface glycoconjugates and the extracellular matrix (ECM) of the proepicardium and the developing epicardium were studied in early mouse embryos by light and electron microscopy with histochaemical and immunocytochaemical ..
  51. ncbi Cyanuric chloride catalyzed mild protocol for synthesis of biologically active dihydro/spiro quinazolinones and quinazolinone-glycoconjugates
    Moni Sharma
    Division of Medicinal and Process Chemistry, CSIR Central Drug Research Institute, Lucknow 226001, India
    J Org Chem 77:929-37. 2012
    ..approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a-3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives...
  52. ncbi Synthesis of multivalent glycoconjugates containing the immunoactive LELTE peptide: effect of glycosylation on cellular activation and natural killing by human peripheral blood mononuclear cells
    Olivier Renaudet
    Departement de Chimie Moleculaire, UMR CNRS 5250 and ICMG FR 2607, Universite Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France
    J Am Chem Soc 132:6800-8. 2010
    ..These unique properties make the combined peptide/carbohydrate RAFTs highly suitable for future evaluation in animal tumor therapies in vivo and predict them to be readily available and efficient immunoactivators...
  53. pmc Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications
    Daniel Garrido
    Department of Food Science and Technology and Foods for Health Institute, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Microbiology 159:649-64. 2013
    ..human milk oligosaccharides, and recent evidence indicates that their activities also target other human milk glycoconjugates. Here, we review advances in our understanding of how these microbes have been shaped by breast milk ..
  54. pmc Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders
    Mary N Burtnick
    Department of Microbiology and Immunology, University of South Alabama Mobile, AL, USA
    Front Cell Infect Microbiol 2:108. 2012
    ..Collectively, these approaches provide a tangible starting point for the development of novel CPS-based glycoconjugates for immunization against melioidosis and glanders.
  55. ncbi Bacillus thuringiensis Cry1A toxin-binding glycoconjugates present on the brush border membrane and in the peritrophic membrane of the Douglas-fir tussock moth are peritrophins
    Algimantas P Valaitis
    USDA Forest Service, Northern Research Station, 359 Main Road, Delaware, OH 43015, USA
    J Invertebr Pathol 112:1-8. 2013
    ..These data provide strong evidence that O-linked glycans are the target structures on the toxin-binding glycoconjugates for the Cry1A class of insecticidal proteins in DFTM larvae.
  56. pmc Circulating Biomphalaria glabrata hemocyte subpopulations possess shared schistosome glycans and receptors capable of binding larval glycoconjugates
    Timothy P Yoshino
    Department of Pathobiological Sciences, University of Wisconsin, School of Veterinary Medicine, Madison, WI 53706, USA
    Exp Parasitol 133:28-36. 2013
    ..Unraveling the functional significance of these naturally expressed and acquired shared glycans on specific hemocyte populations represents an important challenge for future investigations...
  57. ncbi Application of surface plasmon resonance for the detection of carbohydrates, glycoconjugates, and measurement of the carbohydrate-specific interactions: a comparison with conventional analytical techniques. A critical review
    Gulnara Safina
    Department of Chemistry, University of Gothenburg, Gothenburg, Sweden
    Anal Chim Acta 712:9-29. 2012
    ..A few selected examples of the SPR approaches developed during 2004-2011 for the biosensing of glycoforms and for glycan-protein affinity studies are comprehensively discussed...
  58. doi Differentiation between structurally homologous Shiga 1 and Shiga 2 toxins by using synthetic glycoconjugates
    Ramesh R Kale
    Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221 0172, USA
    Angew Chem Int Ed Engl 47:1265-8. 2008
  59. ncbi Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2007-2008
    David J Harvey
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Mass Spectrom Rev 31:183-311. 2012
    ..review, published in 1999, on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2008...
  60. ncbi The presence of Lewis a epitopes in Arabidopsis thaliana glycoconjugates depends on an active alpha4-fucosyltransferase gene
    R Leonard
    Equipe de Glycobiologie et Biotechnologie EA 3176, Institut des Sciences de la Vie et de la Santé, Universite de Limoges, Faculte des Sciences, 123, Avenue Albert Thomas, 87060 Limoges, France
    Glycobiology 12:299-306. 2002
    ..When expressed in COS 7 cells the protein is able to transfer Fuc from GDP-Fuc to a type 1 acceptor substrate, but this transferase activity is detected only in the culture medium of transfected cells..
  61. ncbi Carbohydrate diversity: synthesis of glycoconjugates and complex carbohydrates
    Alexandra Hölemann
    Eidgenossische Technische Hochschule Zurich, Laboratory for Organic Chemistry, ETH Honggerberg, HCI F315, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Curr Opin Biotechnol 15:615-22. 2004
    The fundamental role of glycoconjugates in many biological processes is now well appreciated and has intensified the development of innovative and improved synthetic strategies...
  62. ncbi Histochemical study of glycoconjugates in the toadfish Halobatrachus didactylus oesophagus epithelium
    S Desantis
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine, University of Bari, Italy
    Histol Histopathol 22:23-35. 2007
    ..Neu5AcForssman pentasaccharide (MAL II, SNA, KOH-sialidase-DBA staining) as well as asialo-glycoconjugates with terminal/internal alphaMan (Con A affinity) and with terminal Galbeta1,3GalNAc, Forssman pentasaccharide,..
  63. ncbi Lectin-binding pattern of the Senegalese sole Solea senegalensis oogenesis
    Gianluca Accogli
    Department of Animal Production, Faculty of Veterinary Medicine, University of Bari Aldo Moro, Valenzano, Bari, Italy
    Microsc Res Tech 75:1124-35. 2012
    ..These findings demonstrate that the glycan pattern of fish ovarian follicles changes during the maturative stages and that it is affected by culture-rearing conditions...
  64. ncbi Modulatory efficacy of green tea polyphenols on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis-A therapeutic approach
    Periasamy Srinivasan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India
    Chem Biol Interact 162:149-56. 2006
    ..The present study is aimed to understand the therapeutic action of GTP on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide (4-NQO)-induced oral cancer over a period of 30 days at ..
  65. ncbi Neoglycoconjugates of mannan with bovine serum albumin and their interaction with lectin concanavalin A
    D Mislovicová
    Institute of Chemistry, Slovak Academy of Sciences, SK 842 38 Bratislava, Slovakia
    Bioconjug Chem 13:136-42. 2002
    ..In conclusion, characterization of synthetic neoglycoconjugates confirmed that the method used for their preparation retained the ability of mannan moiety to interact with concanavalin A...
  66. ncbi Histochemical analysis of glycoconjugates in the skin of a catfish (arius tenuispinis, day)
    A Al-Banaw
    Medical Laboratory Sciences Department, Kuwait University, Sulaibekhat, Kuwait
    Anat Histol Embryol 39:42-50. 2010
    ..5) as well as using a battery of 14 fluorescein isothiocyanate (FITC)-labelled lectins to identify glycoconjugates present in 10 different areas of the skin of a catfish (Arius tenuispinis) was carried out...
  67. ncbi Identification of fucosylated glycoconjugates in Xenopus laevis testis by lectin histochemistry
    Galder Valbuena
    Departamento de Biología Celular e Histología, Facultad de Medicina y Odontologia, Universidad del Pais Vasco Euskal Herriko Unibertsitatea, 48940 Leioa Vizcaya, Spain
    Histochem Cell Biol 134:215-25. 2010
    b>Glycoconjugates play roles in many physiological and pathological processes...
  68. ncbi Enzymatic synthesis and properties of glycoconjugates with legionaminic acid as a replacement for neuraminic acid
    David C Watson
    Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada
    Glycobiology 21:99-108. 2011
    ..In order to explore the biological effects of replacing sialic acid residues (Neu5Ac) in glycoconjugates with Leg in its diacetylated form, diacetyllegionaminic acid (Leg5Ac7Ac), we tested CMP-Leg5Ac7Ac as a donor ..
  69. ncbi Marine glycobiology: current status and future perspectives
    Gary S Caldwell
    School of Marine Science and Technology, Newcastle University, Ridley Building, Claremont Road, Newcastle upon Tyne NE17RU, England, UK
    Mar Biotechnol (NY) 12:241-52. 2010
    ..with recent advances in analytical instrumentation, there is now the capacity to begin to characterize marine glycoconjugates,many of which will have potential biomedical and biotechnological applications...
  70. ncbi Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for the period 2005-2006
    David J Harvey
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford OX1 3QU, UK
    Mass Spectrom Rev 30:1-100. 2011
    ..review, published in 1999, on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2006...
  71. pmc The terminal sialic acid of glycoconjugates on the surface of intestinal epithelial cells activates excystation of Cryptosporidium parvum
    Naheed Choudhry
    Centre for Gastroenterology, Institute for Cell and Molecular Science, Barts and the London School of Medicine, Newark Street, University of London, London E1 2AD, United Kingdom
    Infect Immun 76:3735-41. 2008
    ..These results suggest that sialic acid on the surface of enterocytes may provide an important local signal for the excystation of C. parvum sporozoites...
  72. ncbi A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility
    Craig Fleming
    Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
    Nat Chem Biol 1:270-4. 2005
    ....
  73. ncbi Glycoconjugate histochemistry and nNOS immunolocalization in the mantle and foot epithelia of Tapes philippinarum (bivalve mollusc)
    Concetta Calabro
    Department of Animal Biology and Marine Ecology, Faculty of Science, University of Messina, Italy
    Folia Histochem Cytobiol 43:151-6. 2005
    ..nNOS immunoreactivity in the intraepithelial and intradermal cells and in the mucocytes suggested a regulatory role of NO in mucus secretion, as demonstrated also in other invertebrates...
  74. ncbi Synthesis, characterization, and preliminary biological study of glycoconjugates of poly(styrene-co-maleic acid)
    Ivan Donati
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Via L Giorgieri 1, I 34127, Trieste, Italy
    Biomacromolecules 3:805-12. 2002
    ..Biological activity tests showed that both SMA-Gal and SMA-Lac allow adhesion of HepG2 hepatic cells about five times larger than that of hydrolyzed, underivatized SMA...
  75. ncbi Design and synthesis of new classes of heterocyclic C-glycoconjugates and carbon-linked sugar and heterocyclic amino acids by asymmetric multicomponent reactions (AMCRs)
    Alessandro Dondoni
    Dipartimento di Chimica, Laboratorio di Chimica Organica, Universita di Ferrara, Via L Borsari 46, I 44100 Ferrara, Italy
    Acc Chem Res 39:451-63. 2006
    ....
  76. ncbi HNK-1 sulfotransferase null mice express glucuronyl glycoconjugates and show normal cerebellar granule neuron migration in vivo and in vitro
    Denise K H Chou
    Department of Biomedical Sciences, E K Shriver Center at University of Massachusetts Medical School, Waltham 02452, USA
    J Neurochem 82:1239-51. 2002
    ..However, the role of other compensatory molecules involved in these processes cannot be completely ruled out...
  77. ncbi Histochemical analysis of glycoconjugates in the eccrine glands of the raccoon digital pads
    T Yasui
    Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan
    Eur J Histochem 48:393-402. 2004
    ..In the eccrine glands, the dark cells exhibited neutral and acidic glycoconjugates with different saccharide residues (alpha-L-fucose, beta-D-galactose, beta-N-acetyl-D-glucosamine and N-..
  78. ncbi Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 41:916-25. 2011
    ..Both neo-glycoconjugates showed, even at low doses, improved uptake as compared with native OVA, resulting in enhanced cross-..
  79. ncbi Histochemistry of glycoconjugates in mucous cells of Salmo trutta uninfected and naturally parasitized with intestinal helminths
    G Bosi
    Department of Veterinary Sciences and Technologies for Food Safety, Faculty of Veterinary Medicine, University of Milan, via Trentacoste n 2, 20134 Milan, Italy
    Dis Aquat Organ 64:45-51. 2005
    ..of the brown trout, the total mucous cell number, and the number of mucous cells containing acid or mixed glycoconjugates were significantly enhanced...
  80. ncbi Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands
    David Deniaud
    Universite de Nantes, CEISAM, Chimie et Interdisciplinarité, Synthèse, Analyse, Modelisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, Rue de la Houssiniere, BP 92208, 44322 Nantes Cedex 3, France
    Org Biomol Chem 9:966-79. 2011
    ..The resulting multivalent glycoconjugates often display a much higher binding affinity for their targets compared to their monovalent counterparts, a ..
  81. ncbi Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Galbeta1-4Fuc disaccharide unit which is present in Protostomia glycoconjugates
    Tomoharu Takeuchi
    Department of Biological Chemistry, School of Pharmaceutical Sciences, Teikyo University, 1091 1 Suarashi, Sagamiko, Sagamihara, Kanagawa 229 0195, Japan
    Glycobiology 19:1503-10. 2009
    ..Furthermore, since glycans containing the Galbeta1-4Fuc disaccharide unit have been found in organisms belonging to Protostomia, this unit might be a common glyco-epitope recognized by galectins in these organisms...
  82. ncbi A chemical surface modification of chitosan by glycoconjugates to enhance the cell-biomaterial interaction
    Yu Chi Wang
    Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan
    Biomacromolecules 4:224-31. 2003
    ....
  83. ncbi Identification of glycoconjugates in the urine of a patient with congenital disorder of glycosylation by high-resolution mass spectrometry
    Sergey Y Vakhrushev
    Institute for Medical Physics and Biophysics, Biomedical Analysis Department, University of Munster, Munster, Germany
    Proteomics 6:983-92. 2006
    ..Taking advantage of this strategy, the number of compositions assigned to mass peaks was significantly increased in a fraction obtained from urine by size exclusion and anion exchange chromatography...
  84. ncbi Echinococcus granulosus: induction of T-independent antibody response against protoscolex glycoconjugates in early experimental infection
    Adriana Baz
    Catedra de Inmunologia, Dpto Biociencias, Facultad de Quimica, Universidad de la Republica, Casilla de Correos 1157, Montevideo, Uruguay
    Exp Parasitol 119:460-6. 2008
    ..In conclusion, the results presented here directly support the existence of T-independent immunogens in E. granulosus protoscoleces and suggest that T-independent antibody response may be quantitatively important in early infection...
  85. ncbi Oligosaccharides and glycoconjugates in human milk: their role in host defense
    D S Newburg
    Department of Biochemistry, Shriver Center for Mental Retardation, Waltham, Massachusetts 02254, USA
    J Mammary Gland Biol Neoplasia 1:271-83. 1996
    ..Prominent among postulated defense agents are the milk oligosaccharides and glycoconjugates. Their complex carbohydrate structures are thought to be assembled by the same enzymes, the ..
  86. ncbi Sulfated glycoconjugates enhance CD36-dependent adhesion of Plasmodium falciparum-infected erythrocytes to human microvascular endothelial cells
    C J McCormick
    Adhesion and Infection Laboratory and the Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Blood 96:327-33. 2000
    ..The sulfated glycoconjugates heparin, fucoidan, dextran sulfate 5000, and dextran sulfate 500 000 caused a dramatic increase in adhesion ..
  87. ncbi Proteome analysis of Aspergillus fumigatus total membrane proteins identifies proteins associated with the glycoconjugates and cell wall biosynthesis using 2D LC-MS/MS
    Haomiao Ouyang
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
    Mol Biotechnol 44:177-89. 2010
    We attempted to identify membrane proteins associated with the glycoconjugates and cell wall biosynthesis in the total membrane preparations of Aspergillus fumigatus...
  88. pmc Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies
    Gerald F Späth
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Infect Immun 72:3622-7. 2004
    Different Leishmania species rely to different extents on abundant glycoconjugates, such as lipophosphoglycan (LPG) and related molecules, in mammalian infections...
  89. ncbi Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae
    Samantha J King
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Microbiol 59:961-74. 2006
    ..pneumoniae to deglycosylate human targets and suggest that in addition to NanA, BgaA and StrH also contribute to pneumococcal colonization and/or pathogenesis...
  90. ncbi GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida
    P W Denny
    Wellcome Trust Laboratories for Molecular Parasitology, Department of Biochemistry, Imperial College of Science, Technology and Medicine, SW7 1AZ, London, UK
    FEBS Lett 491:148-53. 2001
    ..the divergent eukaryotic parasites, Leishmania and Trypanosoma, are highly specialised, with a thick coat of glycoconjugates and glycoproteins playing a central role in virulence...
  91. pmc Glycoconjugate Data Bank: Structures--an annotated glycan structure database and N-glycan primary structure verification service
    Taku Nakahara
    Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Frontier Research Center for the Post Genomic Science and Technology, Hokkaido University, Sapporo, Japan
    Nucleic Acids Res 36:D368-71. 2008
    ..The results of getCARBO are stored and presented in GDB:Structures...
  92. pmc Glycoconjugate binding of gastric and enterohepatic Helicobacter spp
    Sean O Hynes
    Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden
    Infect Immun 71:2976-80. 2003
    ..In addition, in H. hepaticus and H. bilis, binding may be sialic acid dependent. The presence or absence and differences in the levels of activity of lectin adhesins may reflect the species' ecological niche...
  93. ncbi Biotinylated multivalent glycoconjugates for surface coating
    Alexander A Chinarev
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
    Methods Mol Biol 600:67-78. 2010
    ..Here we describe a synthetic approach to polyacrylamide-based glycoconjugates with biotin tag, with special emphasis to development of carbohydrate biosensors and arrays.
  94. ncbi Loss of phospholipid membrane asymmetry and sialylated glycoconjugates from erythrocyte surface in haemoglobin E beta-thalassaemia
    Sumanta Basu
    Biophysics Division, Saha Institute of Nuclear Physics, 1 AF Bidhannagar, Kolkata, India
    Br J Haematol 141:92-9. 2008
    ..A more facilitated vesiculation process in HbEbeta-thalassaemic erythrocytes could lead to faster shedding of glycophorin-containing microvesicles, leaving highly PS-exposed erythrocytes accessible to phagocytes...
  95. pmc Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
    Chang Jun Liu
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Proc Natl Acad Sci U S A 99:14578-83. 2002
    ..The bottleneck for constitutive isoflavone production in Arabidopsis is, therefore, competition for flavanone between IFS and endogenous flavonol synthesis, and the flavonol pathway is reciprocally but disproportionately affected by IFS...
  96. ncbi Distribution of glycoconjugates during cochlea development in mice: light microscopic lectin study
    Joaquin Rueda
    Departamento de Histología y Anatomía, Facultad de Medicina, Universidad Miguel Hernandez, San Juan de Alicante, Spain
    Anat Rec A Discov Mol Cell Evol Biol 274:923-33. 2003
    During development, different epithelial cells in the mouse cochlea express different cell surface glycoconjugates, which may reflect membrane specialization...
  97. ncbi Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis
    Simon Ballance
    School of Biological Sciences, University of Manchester, Manchester M13 9PL, UK
    Comp Biochem Physiol B Biochem Mol Biol 137:475-86. 2004
    We have studied the glycoconjugates in trail mucus of the pond snail Lymnaea stagnalis...
  98. ncbi Glycoconjugates of choroidal neovascular membranes in age-related macular degeneration
    Robert F Mullins
    Center for Macular Degeneration, Department of Ophthalmology and Visual Science, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Mol Vis 11:509-17. 2005
    ..The purpose of this study was to characterize the carbohydrate groups associated with CNV by lectin histochemistry...
  99. pmc Lectin binding patterns in nonsensory regions of rat cochlea during postnatal development
    K M Khan
    Department of Anatomy, The Aga Khan University, Karachi, Pakistan
    J Anat 194:497-504. 1999
    The distribution of glycoconjugates was examined in the nonsensory regions of the rat cochlea during postnatal development using biotin-conjugated lectins...
  100. ncbi Glycoconjugates in sperm function and gamete interactions: how much sugar does it take to sweet-talk the egg?
    A B Diekman
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, 516, Little Rock, Arkansas 72205, USA
    Cell Mol Life Sci 60:298-308. 2003
    b>Glycoconjugates in the mammalian reproductive tract are critical components of the molecular mechanisms that control sperm maturation, sperm transport and gamete interactions...
  101. ncbi Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface
    N M Novozhilova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Biochemistry (Mosc) 75:686-94. 2010
    ....

Research Grants63

  1. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..Thomas Baranski, WU);(4) Role of glycoconjugates and sphingolipids in kinetoplastid parasite growth and virulence (Dr. Steven Beverley, WU, and Dr...
  2. Investigation on Oligosaccharides as Antimicrobial and Prebiotics
    Peng George Wang; Fiscal Year: 2013
    ..These beads function as stable and versatile synthetic reagents, which can be used to synthesize a variety of glycoconjugates in cell-free systems...
  3. Photocrosslinking characterization of heat-labile toxin glycoreceptors
    Amberlyn M Wands; Fiscal Year: 2013
    ..is believed to be that of the monosialoganglioside GM1a, but its targeted binding pocket can also accommodate glycoconjugates carrying terminal N- acetyllactosamine (Gal[unreadable]1-4GlcNAc[unreadable]1-3-R) epitopes (albeit with ..
  4. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Salvatore J Turco; Fiscal Year: 2012
    ..Leishmania express a family of structurally interrelated glycoconjugates, dominated by its surface lipophosphoglycan (LPG), that have critical roles in parasite survival and ..
  5. Synthetic Oligosaccharides for Probing Infection and Innate Immunity
    Geert Jan Boons; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although it is widely appreciated that host and pathogen derived glycoconjugates play key roles in infection and immunity, molecular details of these processes are often difficult to dissect due to ..
  6. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..The long-term goal of the PI's research is to make synthetic complex carbohydrates and glycoconjugates more accessible to general chemical, biochemical, and industrial audiences to keep pace with the exploding ..
  7. Synthesis of immunogenic glycolipopeptides for the development of vaccines for Ch
    Katja Michael; Fiscal Year: 2010
    ..Our goal is to construct fully synthetic glycoconjugates that resemble the cell surface of the parasite, and test them in immunization studies in mice...
  8. Development and Testing of Novel Glanders Vaccine Candidates
    Paul J Brett; Fiscal Year: 2011
    ..thailandensis OPS mutants. The goal of the current research proposal is to synthesize a variety of OPS-based glycoconjugates and evaluate their protective capacity in an animal model of glanders...
  9. Epithelial Glycoconjugates as Barriers against Enteric Infections
    Nicholas J Mantis; Fiscal Year: 2013
    ..The expression patterns of these glycoconjugates can thus impact the host's underlying susceptibility to infection...
  10. Modulation of MUC1 Mucin Trafficking
    Rebecca P Hughey; Fiscal Year: 2010
    ..proteins secreted by a non-classical pathway from the cytoplasm to cross-link extracellular glycoconjugates. Therefore, we will test the hypothesis that apical targeting of MUC1 and formation of an EGFR-MUC1 complex ..
  11. Identification of a Parasite-Specific, Lipid-Metabolic Pathway Essential for Leis
    Kai Zhang; Fiscal Year: 2009
    ..In comparison to membrane proteins and glycoconjugates, the biology of lipids has been extremely understudied in protozoan pathogens...
  12. Excessive Lysosomal Exocytosis Triggers Pathogenic Mechanisms in Sialidosis Mice
    ALESSANDRA D'AZZO; Fiscal Year: 2013
    ..NEU1 initiates the hydrolysis of sialo-glycoconjugates by removing their terminal sialic acids...
  13. Effects of Shear on Specific Adhesion Receptor Expression and Binding in the Bact
    James D Bryers; Fiscal Year: 2010
    ..g., blood plasma proteins, carbohydrates, and glycoconjugates) is a critical first step in a cascade of processes leading to biofilm formation;host tissue invasion, ..
  14. Virulence Mechanisms in Candida Glabrata
    Carlos A Gomez; Fiscal Year: 2010
    ..I wish to determine the structural basis of Epa-mediated binding to host glycoconjugates, This will be done by X ray crystallographic analysis of the lectin domain of one or more Epa proteins...
  15. Chemical tools for studying fucosylated glycans
    Peng Wu; Fiscal Year: 2013
    ..harness fucosyl activation and transfer enzymes from bacterial sources to synthesize fucosylated glycans and glycoconjugates for their functional studies...
  16. Metabolic Engineering of Cancer for Immunotargeting
    Zhongwu Guo; Fiscal Year: 2012
    ..This proposal will continue to test various glycoconjugates as vaccines for the new immunotherapeutic strategy, verify other related issues, and evaluate in vitro and in ..
  17. Functional Characterization of Leishmania Transporters
    Scott M Landfear; Fiscal Year: 2010
    ..These fates of glucose include: i) incorporation into glycoconjugates and complex carbohydrates, ii) metabolism via the pentose phosphate pathway to generate NADPH and ribose ..
  18. Fucosyl transferases in inflammation and angiogenesis
    Alisa E Koch; Fiscal Year: 2013
    ..Moreover, this antigen is inducible and upregulated in human RA ST. MAb 4A11 detects the glycoconjugates H-5-2 (abbreviated H) and Lewisy-6 (Ley), collectively termed Ley/H...
  19. Glycoconjugates and Cardiovascular Disease
    Gerald Warren Hart; Fiscal Year: 2013
    ..We have assembled a team of leading and rising star glycoscientists to not only elucidate the roles of glycoconjugates in cardiovascular disease and cardioprotection during ischemia, but also to be able to create a world-class ..
  20. The Role of Human Milk in Infant Nutrition and Health
    Ardythe L Morrow; Fiscal Year: 2013
    ..milk glycans, particularly, the a1,2 fucosyl ("secretor") oligosaccharides and their high molecular weight glycoconjugates, are a major new class of antimicrobial agents...
  21. High-specificity affinity reagents for N-glycosylation site mapping and glycomics
    Robert J Woods; Fiscal Year: 2013
    ..Therefore, a single change in a cell's glycosylation machinery can affect many different glycoconjugates. To effectively employ and discover glycan disease markers new glycan-specific reagents are urgently needed...
  22. GLYCOLIPIDS AND EXPERIMENTAL NEUROPATHY
    Robert K Yu; Fiscal Year: 2012
    ..These glycoconjugates include bacterial lipopolysaccharides (LPSs) that share carbohydrate epitopes similar to those of GSLs...
  23. PGT Inhibitors Mapped From a Tunicamycin Blueprint
    Barbara Imperiali; Fiscal Year: 2013
    ..Such glycoconjugates play critical roles in the interactions of microbial pathogens with the hosts that they infect, however, ..
  24. Protein-glycan Interactions in the Vascular System
    Lijun Xia; Fiscal Year: 2013
    ..The data obtained will enhance our understanding of the functions of lectins and glycoconjugates during inflammation, thrombosis, and vascular development...
  25. Glycoconjugate therapeutic peptides for improved treatment of human diseases
    ADAM CHARLES FISHER; Fiscal Year: 2013
    ..This will be accomplished through the following specific aims: (1) express a panel of therapeutic peptide glycoconjugates and screen for expression and glycosylation efficiency;and (2) screen glycoconjugate drug candidates for ..
  26. Chemical Cell Surface Engineering
    Carolyn R Bertozzi; Fiscal Year: 2013
    ..The biological functions of natural glycoconjugates are difficult to study due to a dearth of experimental tools...
  27. Impact of glycosylation on PsrP function
    Anel Lizcano; Fiscal Year: 2013
    ..To investigate and compare the composition of the glycoconjugates present on PsrP, glycosylated and unglycosylated purified protein was analyzed by High Performance Anion ..
  28. Inhibition of Glycoprotein Biosynthesis in Gram-Negative Pathogens
    Barbara Imperiali; Fiscal Year: 2013
    ..In the past decade bacterial cell surface glycoconjugates, including the lipopolysaccharide (LPS) component of the outer cell wall and cell surface N- and O-linked ..
  29. Glycobiological Analysis of Plasmodium-Vector Host Interactions
    RHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2010
    ..Research Design: The research plan includes: a) functional analyses of mosquito midgut glycoconjugates during Plasmodium invasion through RNAi knock-down of mosquito glycosyl- and sulfo-transferases, b) proteomic ..
  30. Inhibition of prokaryote-specific saccharide biosynthesis in microbial pathogens
    Barbara Imperiali; Fiscal Year: 2013
    ..Just in the last few years bacterial cell surface glycoconjugates, including the lipopolysaccharide component of the outer cell wall and cell surface N- and O-linked ..
  31. Integrated Technology Resource for Biomedial Glycomics
    JAMES MICHAEL PIERCE; Fiscal Year: 2011
    ..technologies and tools for the biomedical community to facilitate the study of glycomics: the glycans, glycoconjugates, proteins that regulate their expression, and proteins that recognize them...
  32. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..g.,following spinal cord injury or stroke), where there is experimental evidence that they may have therapeutic utility. ..
  33. New strategies for expeditious oligosaccharide synthesis
    Alexei V Demchenko; Fiscal Year: 2011
    ..belief that exciting scientific discoveries will simplify the synthesis of complex oligosaccharides and glycoconjugates and help to incorporate novel insights into the curriculum as learning tools...
  34. Shotgun Glycomics: Linking Glycan Structure and Function
    David F Smith; Fiscal Year: 2011
    ..in "glyco-chemistry" that allow us to fluorescently tag free glycans released from specific cell or tissue glycoconjugates. These novel, bifunctional, fluorescent tags allow us to detect sub-microgram quantities of glycans that are ..
  35. Mechanistic Investigation of the Mycobacterial Glycosyltransferase GlfT2
    Matthew R Levengood; Fiscal Year: 2010
    ..of pyranose sugars in biology is emerging, but comparatively less is known about furanose-containing glycoconjugates. The presence of these glycans in various microbes demonstrates their importance...
  36. NATIONAL CENTER FOR BIOMEDICAL GLYCOMICS
    J Michael Pierce; Fiscal Year: 2013
    ..can be defined in several ways, but in terms of our Center, we define Glycomics as the study of glycans, glycoconjugates, the proteins that regulate their expression, and the proteins that recognize them;in particular, we are ..
  37. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
    NDP-sugar glycosyltransferases are critical for the biosynthesis of all complex carbohydrates and glycoconjugates. This large and diverse class of enzymes catalyzes the transfer of saccharide units onto the target compounds to create a ..
  38. Photogenerated Carbohydrate Microarrays
    Mingdi Yan; Fiscal Year: 2012
    ..array chemistries will accommodate a wide range of carbohydrates from simple monosaccharides to more complex glycoconjugates. In Aim 2, the impact of ligand display (ligand presentation, linker length, matrix) on binding affinity and ..
  39. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..The following proposal will test possible roles for astrocytes and glycoconjugates during normal and abnormal development of a clinically important area of the brain, the nigrostriatal circuit...
  40. Chemical Protein Glycosylation
    KAI H GRIEBENOW; Fiscal Year: 2012
    ..g., structural dynamics, thermodynamic stability) of the glycoconjugates and with the chemical glycosylation variables (e.g...
  41. 'Immunity of Schistosome Glycoconjugates'
    Richard Cummings; Fiscal Year: 2001
    ..2) We will develop new diagnostic immunoassays to detect for the presence of (a) antibodies to schistosome glycoconjugates and (b) circulating schistosome glycoconjugates using available monoclonal antibodies (mabs) and additional ..
  42. Phosphomannomutase (PMM) as a Novel Drug Target for the Parasite Leishmania
    JUSTIN WYATT; Fiscal Year: 2007
    ..Leishmania is known to synthesize a range of mannose-rich glycoconjugates called phosphoglycans that form the cell surface or that are secreted; these are the molecules involved in ..
  43. Carbohydrate-Dependent Adhesion in Normal and Tumor Cells
    Minoru Fukuda; Fiscal Year: 2012
    ..The work centers around sulfated, fucosylated glycoconjugates in lymphocyte trafficking, tumor progression, and myelopoiesis...
  44. GLYCOCONJUGATES IN SYMPATHO-ADRENAL DEVELOPMENT
    GERALD SCHWARTING; Fiscal Year: 1990
    The objectives of this proposal are to elucidate the regulation and function of cell surface glycoconjugates in the development of cells of sympatho-adrenal lineage, and to identify specific glycoconjugates as stage- and lineage-specific ..
  45. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2003
    ..protein which mediates cell-cell adhesion early in this immune response by binding to leukocyte surface glycoconjugates. The identification of normal human granulocyte glycoconjugates responsible for E-selectin-mediated cell ..
  46. Control of Immune Cell Sialylation
    KENTON MILLER; Fiscal Year: 2007
    ..B cell function requires the appropriate expression of multiple lineage and developmental-stage specific glycoconjugates. Further, the glycan portion of at least one such glycoconjugate requires a 2,6-linked sialic acid residue ..
  47. GLYCOCONJUGATES INVOLVED IN HOST/PARASITE INTERACTIONS
    BIBHUTI SINGH; Fiscal Year: 2002
    ..Cell surface glycoconjugates appear to mediate parasite binding to host cells...
  48. SIALIC ACID MODULATION REGULATES NEUTROPHIL DIAPEDESIS
    Alan Cross; Fiscal Year: 2002
    ..Adapted from the applicant's abstract): Sialic acids are amino sugars that are present on mammalian cells as glycoconjugates and impart to these cells a negative surface charge...
  49. Studies of naturally occurring structurally modified carbohydrates
    Xi Chen; Fiscal Year: 2010
    ..modifications due to technical difficulties in obtaining homogenous structurally modified carbohydrates and glycoconjugates. The long-term goal of this program is to develop novel chemo-enzymatic methods for synthesizing structurally ..
  50. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2009
    ..acting as alternate substrates (decoys), and alter the expression of sialyl Lewis X (sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the ..
  51. GLYCOSIDE ANTAGONISTS OF GLYCOSYLATION
    Jeffrey Esko; Fiscal Year: 2000
    ..b>Glycoconjugates play important roles in inflammation, tumor cell migration, and infection...
  52. 'Immunity of Schistosome Glycoconjugates'
    Richard Cummings; Fiscal Year: 2003
    ..to be obtained to develop new diagnostic immunoassays to detect the presence of circulating schistosome glycoconjugates and antibodies to these glycoconjugates...
  53. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2009
    ..Based upon the findings, the central hypothesis is that the uptake and storage of glycoconjugates play an important role in effecting a prolonged innate immune response, breach of the blood brain barrier (..
  54. MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
    Catherine E Costello; Fiscal Year: 2013
    ..Ion mobility mass spectrometry will be investigated for the analysis of glycans, glycoconjugates and complex peptide mixtures and for the characterization of noncovalent complexes...
  55. Biosynthesis and transbilayer flipping of mycobacterial PIM glycolipids
    Delphi Chatterjee; Fiscal Year: 2009
    ..of mycobacteria, because they are biosynthetic precursors in the assembly of the key cell surface glycoconjugates lipomannan (LM) and lipoarabinomannan (LAM)...
  56. CHEMISTRY AND BIOCHEMISTRY OF GLYCOCONJUGATES
    YUAN LEE; Fiscal Year: 2005
    ..The first two systems bind Galalpha (1-4)Gal segment (galabiose) of glycoconjugates, but binding of Gal-containing materials by CRP has not been carefully studied...
  57. GLYCOPROTEIN SHEDDING AND METASTASIS
    BRUCE BOSMANN; Fiscal Year: 1980
    b>Glycoconjugates, primarily glycoproteins, are implicated in oncogenesis, maintenance of the neoplastic state and metastasis...
  58. ETHANOL CEREBELLAR PATHOLOGY--RETINOIDS AND GLYCOLIPIDS
    M Ullman; Fiscal Year: 2001
    ..embryonic antigen-1 (SSEA-1) and 9-O-acetyl gangliosides (JONES); antigens thought to be essential glycoconjugates for cell adhesion to and migration along glial processes in the developing cerebellum...
  59. SYNTHESES APPLICATIONS OF ALPHA GALACTOSYL EPITOPES
    Peng Wang; Fiscal Year: 2002
    ..were shown to enhance antigen presentation by the natural human anti-Gal antibody, and alpha-Gal-immunotoxin glycoconjugates are being used to target B cells which generate anti-Gal antibody...
  60. DEVELOPMENT GLYCOBIOLOGY OF CAENORHABDITIS ELEGANS
    Richard Cummings; Fiscal Year: 2003
    b>Glycoconjugates are important in cell recognition/adhesion and protein targeting/folding...
  61. Shared Instrumentation Grant: LTQ Linear Ion Trap Mass Spectrometer
    Jeffrey Esko; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Glycoconjugates play crucial roles in many fundamental biological processes, and changes in glycan structure correlate with certain diseases and disorders...
  62. MOUSE GALTRANSFERASE--STRUCTURE/EXPRESSION
    JOEL SHAPER; Fiscal Year: 2004
    b>Glycoconjugates are a major class of molecules found on the surface of all cells including developing male germ cells...
  63. 2013/2015 Glycobiology Gordon Research Conference &Gordon Research Seminar
    Kelley W Moremen; Fiscal Year: 2013
    ..conferences will continue a tradition of emphasis on the structure, function, and biology of macromolecular glycoconjugates. Oral sessions will include: glycan diversity (keynote session), glycosylation and quality control, structure ..