glucosamine

Summary

Top Publications

  1. ncbi Dietary supplements for osteoarthritis
    Philip J Gregory
    Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska 68178, USA
    Am Fam Physician 77:177-84. 2008
  2. pmc Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
    Simon Wandel
    Institute of Social and Preventive Medicine, University of Bern, Switzerland
    BMJ 341:c4675. 2010
  3. doi Glucosamine modulates TNF-α-induced ICAM-1 expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells
    Ching Long Chen
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Invest Ophthalmol Vis Sci 53:2281-91. 2012
  4. ncbi The glucosamine controversy; a pharmacokinetic issue
    Ali Aghazadeh-Habashi
    University of Alberta, Edmonton, AB Canada
    J Pharm Pharm Sci 14:264-73. 2011
  5. ncbi Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis
    Gabrielle Tiraloche
    Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Arthritis Rheum 52:1118-28. 2005
  6. pmc A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals
    R R Simon
    Cantox Health Sciences International, Mississauga, ON, Canada
    Diabetes Metab Res Rev 27:14-27. 2011
  7. ncbi Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis
    Florent Richy
    Faculty of Medicine, Department of Public Health, Public Health and Epidemiology, University of Liege, Liege, Belgium
    Arch Intern Med 163:1514-22. 2003
  8. pmc Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
    Allen D Sawitzke
    University of Utah School of Medicine, 30E 1900 S SOM 4B200, Salt Lake City UT 84132, USA
    Ann Rheum Dis 69:1459-64. 2010
  9. doi Effects of sodium-hyaluronate and glucosamine-chondroitin sulfate on remodeling stage of tenotomized superficial digital flexor tendon in rabbits: a clinical, histopathological, ultrastructural, and biomechanical study
    Ahmad Oryan
    Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
    Connect Tissue Res 52:329-39. 2011
  10. ncbi The allosteric transition of glucosamine-6-phosphate deaminase: the structure of the T state at 2.3 A resolution
    E Horjales
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Cuernavaca, Mor, Mexico
    Structure 7:527-37. 1999

Detail Information

Publications361 found, 100 shown here

  1. ncbi Dietary supplements for osteoarthritis
    Philip J Gregory
    Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska 68178, USA
    Am Fam Physician 77:177-84. 2008
    ..b>Glucosamine-containing supplements are among the most commonly used products for osteoarthritis...
  2. pmc Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
    Simon Wandel
    Institute of Social and Preventive Medicine, University of Bern, Switzerland
    BMJ 341:c4675. 2010
    To determine the effect of glucosamine, chondroitin, or the two in combination on joint pain and on radiological progression of disease in osteoarthritis of the hip or knee. Design Network meta-analysis...
  3. doi Glucosamine modulates TNF-α-induced ICAM-1 expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells
    Ching Long Chen
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Invest Ophthalmol Vis Sci 53:2281-91. 2012
    The purpose of this article was to investigate the effects of glucosamine (GlcN) on the TNF-α-induced expression of intercellular adhesion molecule 1 (ICAM-1) and the function of ICAM-1 in ARPE-19 cells in vitro.
  4. ncbi The glucosamine controversy; a pharmacokinetic issue
    Ali Aghazadeh-Habashi
    University of Alberta, Edmonton, AB Canada
    J Pharm Pharm Sci 14:264-73. 2011
    b>Glucosamine (GlcN) is a naturally occurring aminosugar that is widely used to treat osteoarthritis despite controversial clinical trial results...
  5. ncbi Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis
    Gabrielle Tiraloche
    Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Arthritis Rheum 52:1118-28. 2005
    To determine whether oral glucosamine alleviates cartilage degradation in an animal model of osteoarthritis (OA).
  6. pmc A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals
    R R Simon
    Cantox Health Sciences International, Mississauga, ON, Canada
    Diabetes Metab Res Rev 27:14-27. 2011
    b>Glucosamine (GlcN) is a widely utilized dietary supplement that is used to promote joint health...
  7. ncbi Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis
    Florent Richy
    Faculty of Medicine, Department of Public Health, Public Health and Epidemiology, University of Liege, Liege, Belgium
    Arch Intern Med 163:1514-22. 2003
    To assess the structural and symptomatic efficacy of oral glucosamine sulfate and chondroitin sulfate in knee osteoarthritis through independent meta-analyses of their effects on joint space narrowing, Lequesne Index, Western Ontario ..
  8. pmc Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
    Allen D Sawitzke
    University of Utah School of Medicine, 30E 1900 S SOM 4B200, Salt Lake City UT 84132, USA
    Ann Rheum Dis 69:1459-64. 2010
    ..Knee osteoarthritis (OA) is a major cause of pain and functional limitation in older adults, yet longer-term studies of medical treatment of OA are limited...
  9. doi Effects of sodium-hyaluronate and glucosamine-chondroitin sulfate on remodeling stage of tenotomized superficial digital flexor tendon in rabbits: a clinical, histopathological, ultrastructural, and biomechanical study
    Ahmad Oryan
    Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
    Connect Tissue Res 52:329-39. 2011
    This study was designed to evaluate the effects of sodium-hyaluronate (NaH) combined with glucosamine HCl-chondroitin sulfate (GlcN-CS) on the post-surgical repair of tendon rupture on day 84 post injury...
  10. ncbi The allosteric transition of glucosamine-6-phosphate deaminase: the structure of the T state at 2.3 A resolution
    E Horjales
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Cuernavaca, Mor, Mexico
    Structure 7:527-37. 1999
    The allosteric hexameric enzyme glucosamine-6-phosphate deaminase from Escherichia coli catalyses the regulatory step of N-acetylglucosamine catabolism, which consists of the isomerisation and deamination of glucosamine 6-phosphate (..
  11. pmc Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14
    Nico Marr
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Infect Immun 78:2060-9. 2010
    ..pertussis BP338 can be substituted with glucosamine in a BvgAS-regulated manner...
  12. ncbi Wheat germ agglutinin. Molecular characteristics and specificity for sugar binding
    Y Nagata
    J Biol Chem 249:3116-22. 1974
  13. ncbi Commentary: osteoarthritis of the knee and glucosamine
    R D Altman
    Osteoarthritis Cartilage 14:963-6. 2006
  14. pmc Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes
    Valentina Calamia
    Rheumatology Division, INIBIC CHU A Coruña, As Xubias s n, A Coruña 15006, Spain
    Arthritis Res Ther 12:R138. 2010
    Chondroitin sulfate (CS) and glucosamine sulfate (GS) are symptomatic slow-acting drugs for osteoarthritis (OA) widely used in clinic...
  15. doi A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis
    C Thomas Vangsness
    Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Arthroscopy 25:86-94. 2009
    ..The purpose of this review is to critically evaluate the evidence for the use of glucosamine and chondroitin sulfate for knee OA with the goal of elucidating their indications for clinical use...
  16. doi Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs
    Shin Taniguchi
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1, Ohyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    J Orthop Res 30:673-8. 2012
    Histological and molecular changes were examined to investigate the effects of long-term administration of glucosamine (GlcN) and chondroitin sulfate (CS) in a model of spontaneous osteoarthritis (OA) in Hartley guinea pigs...
  17. pmc Effects of oral glucosamine hydrochloride administration on plasma free amino acid concentrations in dogs
    Kazuo Azuma
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4 101 Koyama Minami, Tottori 680 8553, Japan
    Mar Drugs 9:712-8. 2011
    We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and d-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs...
  18. pmc Brain glucosamine boosts protective glucoprivic feeding
    Mayowa A Osundiji
    University of Cambridge, Institute of Metabolic Science, IMS MRL, Box 289 Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ United Kingdom
    Endocrinology 151:1499-508. 2010
    ..Here we investigated the effects of intracerebroventricular (ICV) infusion of glucosamine (GSN), a GK inhibitor, on food intake at normoglycemia and protective feeding responses during glucoprivation ..
  19. doi Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial
    R M Rozendaal
    Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Osteoarthritis Cartilage 17:427-32. 2009
    Recently we reported that glucosamine sulphate (GS) did not have an effect on the symptoms and progression of primary care patients with hip osteoarthritis (OA)...
  20. ncbi Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review
    I Setnikar
    Scientific Department, Rotta Research Laboratorium, Monza, Italy
    Arzneimittelforschung 51:699-725. 2001
    This article reviews the literature related to the absorption, distribution, metabolism and excretion (ADME) of glucosamine (Gl) in man and in animals after administration of crystalline glucosamine sulfate (CGS)...
  21. ncbi Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model
    Geoff H Werstuck
    Henderson Research Centre, 711 Concession St, Hamilton, Ontario, Canada L8V 1C3
    Diabetes 55:93-101. 2006
    ..We hypothesize that the accumulation of intracellular glucosamine observed in diabetes may also promote atherogenesis via a mechanism that involves ER stress...
  22. pmc The glmS riboswitch integrates signals from activating and inhibitory metabolites in vivo
    Peter Y Watson
    Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA
    Nat Struct Mol Biol 18:359-63. 2011
    ..It is also a ribozyme that self-cleaves upon binding glucosamine-6-phosphate, the product of the enzyme encoded by glmS...
  23. pmc Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
    Lianchun Wang
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    J Clin Invest 110:127-36. 2002
    ..are mainly mediated by blocking P- and L-selectin-initiated cell adhesion; (b) the sulfate groups at C6 on the glucosamine residues play a critical role in selectin inhibition; and (c) some non-anticoagulant forms of heparin retain ..
  24. pmc Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons
    Ligang Zhou
    Department of Pharmacology, University of Cambridge, Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Behav Brain Res 222:274-8. 2011
    ..We previously reported that antagonism of centrally expressed GK by administration of glucosamine (GSN) was sufficient to induce protective glucoprivic feeding in rats...
  25. ncbi Radiologic features poorly predict clinical outcomes in knee osteoarthritis
    Olivier Bruyere
    WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, Liege, Belgium
    Scand J Rheumatol 31:13-6. 2002
    ..To assess the impact of radiographic severity and progression on pain and disability...
  26. doi Glucosamine, a naturally occurring amino monosaccharide, inhibits A549 and H446 cell proliferation by blocking G1/S transition
    Yinghua Ju
    Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P R China
    Mol Med Rep 8:794-8. 2013
    Uncontrolled proliferation is important in tumorigenesis. In the present study, the effects of glucosamine on lung cancer cell proliferation were investigated...
  27. pmc Glucosamine activates autophagy in vitro and in vivo
    Beatriz Caramés
    The Scripps Research Institute, La Jolla, CA, USA
    Arthritis Rheum 65:1843-52. 2013
    ..The objective of this study was to determine whether glucosamine can activate autophagy.
  28. pmc Solvation properties of N-acetyl-β-glucosamine: molecular dynamics study incorporating electrostatic polarization
    Yang Zhong
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    J Comput Chem 32:3339-53. 2011
    N-Acetyl-β-glucosamine (NAG) is an important moiety of glycoproteins and is involved in many biological functions...
  29. pmc Use of glucosamine and chondroitin in relation to mortality
    Griffith A Bell
    Cancer Prevention Program, The Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Eur J Epidemiol 27:593-603. 2012
    b>Glucosamine and chondroitin are products commonly used by older adults in the US and Europe. There is limited evidence that they have anti-inflammatory properties, which could provide risk reduction of several diseases...
  30. pmc High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
    V Kolm-Litty
    Institute for Diabetes Research, D 80804 München, Germany
    J Clin Invest 101:160-9. 1998
    ..We tested if structural analogues of D-glucose may mimic the high glucose effect and found that D-glucosamine was strikingly more potent than D-glucose itself in enhancing the production of TGF-beta protein and subsequent ..
  31. doi Glucosamine as carbon source for amino acid-producing Corynebacterium glutamicum
    Andreas Uhde
    Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany
    Appl Microbiol Biotechnol 97:1679-87. 2013
    ..grows with a variety of carbohydrates and carbohydrate derivatives as sole carbon sources; however, growth with glucosamine has not yet been reported...
  32. pmc Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling
    Wei Qiu
    Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, M5G 1X8, Canada
    J Lipid Res 50:1814-23. 2009
    b>Glucosamine impairs hepatic apolipoprotein B100 (apoB100) production by inducing endoplasmic reticulum (ER) stress and enhancing cotranslational and posttranslational apoB100 degradation (Qiu, W., R. K. Avramoglu, A. C. Rutledge, J...
  33. pmc Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells
    Yau Sang Chan
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
    PLoS ONE 7:e38961. 2012
    A dimeric 64-kDa glucosamine-specific lectin was purified from seeds of Phaseolus vulgaris cv. "brown kidney bean...
  34. doi Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial
    Arvind Chopra
    Center for Rheumatic Diseases, 1988 Convent Street, CAMP, Pune, India
    Rheumatology (Oxford) 52:1408-17. 2013
    To demonstrate clinical equivalence between two standardized Ayurveda (India) formulations (SGCG and SGC), glucosamine and celecoxib (NSAID).
  35. ncbi Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins
    Wei Qiu
    Department of Clinical Biochemistry and Pathobiology, Division of Clinical Biochemistry, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Lipid Res 47:1749-61. 2006
    b>Glucosamine-induced endoplasmic reticulum (ER) stress was recently shown to specifically reduce apolipoprotein B-100 (apoB-100) secretion by enhancing the proteasomal degradation of apoB-100...
  36. pmc Coordinated regulation of amino sugar-synthesizing and -degrading enzymes in Escherichia coli K-12
    J A Plumbridge
    Institut de Biologie Physico chimique URA1139, Paris, France
    J Bacteriol 175:4951-6. 1993
    The intracellular concentration of the enzyme glucosamine-6-phosphate synthase, encoded by the gene glmS in Escherichia coli, is repressed about threefold by growth on the amino sugars glucosamine and N-acetylglucosamine...
  37. pmc Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signali
    Niranjan Rajapakse
    Marine Bioprocess Research Center, Pukyong National University, Busan, Korea
    Immunology 123:348-57. 2008
    b>Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications...
  38. ncbi Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution
    G Oliva
    Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Brazil
    Structure 3:1323-32. 1995
    b>Glucosamine 6-phosphate deaminase from Escherichia coli is an allosteric hexameric enzyme which catalyzes the reversible conversion of D-glucosamine 6-phosphate into D-fructose 6-phosphate and ammonium ion and is activated by N-acetyl-D-..
  39. ncbi Glucosamine-induced beta-cell dysfunction: a possible involvement of glucokinase or glucose-transporter type 2
    Hiroyasu Yoshikawa
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 24:228-34. 2002
    The mechanism for beta-cell dysfunction induced by glucosamine has not yet fully been investigated previously.
  40. pmc Who uses glucosamine and why? A study of 266,848 Australians aged 45 years and older
    David Sibbritt
    School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 7:e41540. 2012
    There has been a dramatic increase in the use of complementary medicines over recent decades. Glucosamine is one of the most commonly used complementary medicines in Western societies...
  41. ncbi The effect of glucosamine concentration on the development and sex ratio of bovine embryos
    Koji Kimura
    National Institute of Livestock and Grassland Science, 768 Nasushiobara, Tochigi 329 2793, Japan
    Anim Reprod Sci 103:228-38. 2008
    b>Glucosamine is a component of hyaluronic acid and an alternative substrate to glucose for the extracellular matrix synthesis of COCs. Its addition to an IVM medium reduces the glucose consumption of bovine COCs...
  42. ncbi Correlation of plasma amino acid concentrations and chondroprotective effects of glucosamine and fish collagen peptide on the development of osteoarthritis
    Akihiro Ohnishi
    Department of Veterinary Clinical Medicine, Tottori University, 4 101 Koyama Minami, Tottori, Japan
    J Vet Med Sci 75:497-502. 2013
    We investigated the correlation of plasma amino acid concentrations and the effects of glucosamine and fish collagen peptide (FCP) on osteoarthritis (OA)...
  43. ncbi Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL
    Zhe Wang
    Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, No 17, Changle West Road, Xi an, 710032, PR China
    Apoptosis 11:1851-60. 2006
    ..Here, we show that glucosamine sulfate (GS) inhibits the proliferation and induces apoptosis of human chronic myelogenous leukemia K562 cells ..
  44. ncbi D-glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K
    Hyun Ji Oh
    Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, Daegu 700 712, Republic of Korea
    Biochem Biophys Res Commun 360:840-5. 2007
    Although D-glucosamine has been reported as an inhibitor of tumor growth both in vivo and in vitro, the mechanism for the anticancer effect of D-glucosamine is still unclear...
  45. pmc N-acetylglucosamine and glucosamine-containing arabinogalactan proteins control somatic embryogenesis
    A J Van Hengel
    Laboratory of Molecular Biology, Department of Plant Sciences, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands
    Plant Physiol 125:1880-90. 2001
    ..Here we show that carrot (Daucus carota) AGPs can contain glucosamine and N-acetyl-D-glucosaminyl and are sensitive to endochitinase cleavage...
  46. ncbi Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis
    H Nakamura
    Department of Bioregulation, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    Clin Exp Rheumatol 22:293-9. 2004
    To determine the response of glucosamine hydrochloride on chondrocytes and synoviocytes in terms of prostaglandin E2 (PGE2), nitric oxide (NO) and matrix metalloproteases (MMPs).
  47. doi Glucosamine inhibits epithelial-to-mesenchymal transition and migration of retinal pigment epithelium cells in culture and morphologic changes in a mouse model of proliferative vitreoretinopathy
    Chang Min Liang
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
    Acta Ophthalmol 89:e505-14. 2011
    To explore the effect of glucosamine (GlcN) on transforming growth factor (TGF)-β signalling and several processes involved in proliferative vitreoretinopathy (PVR).
  48. pmc Glucosamine hydrochloride for the treatment of osteoarthritis symptoms
    Beth Anne Fox
    East Tennessee State University, Family Physicians of Kingsport, 201 Cassel Drive, Kingsport, Tennessee 37660, USA
    Clin Interv Aging 2:599-604. 2007
    ..Many studies have sought to find a therapy to relieve pain and reduce disability. Glucosamine hydrochloride (HCl) is one of these therapies. There are limited studies of glucosamine HCl in humans...
  49. pmc Effects of oral glucosamine sulphate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis
    B A Biggee
    Division of Rheumatology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Ann Rheum Dis 66:260-2. 2007
    and objective: Glucosamine is suggested to affect glucose transport and insulin resistance...
  50. doi Effect of a solution of hyaluronic acid-chondroitin sulfate-N-acetyl glucosamine on the repair response of cartilage to single-impact load damage
    Frances M D Henson
    Department of Veterinary Medicine, University of Cambridge, England, UK
    Am J Vet Res 73:306-12. 2012
    To investigate effects of 1% hyaluronic acid-chondroitin sulfate-N-acetyl glucosamine (HCNAG) on the damage repair response in equine articular cartilage.
  51. doi Anti-arthritic effect of GN1, a novel synthetic analog of glucosamine, in the collagen-induced arthritis model in rats
    Huma Jawed
    Pharmacology Unit, Lab 314, H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Inflamm Res 60:1113-20. 2011
    b>Glucosamine is a naturally occurring amino monosaccharide that maintains the elasticity and strength of the cartilage tissues...
  52. doi The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature
    N R Dostrovsky
    Department of Internal Medicine, Queens University, Kingston, Ontario, Canada
    Osteoarthritis Cartilage 19:375-80. 2011
    b>Glucosamine is commonly used for the treatment of osteoarthritis. It is available as an over the counter preparation and also as a prescription pharmaceutical...
  53. pmc The glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphate
    Bo Gong
    Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Am Chem Soc 133:14188-91. 2011
    ..Binding of glucosamine-6-phosphate (GlcN6P) uncovers the latent self-cleavage activity of the RNA, which adopts a catalytically ..
  54. ncbi Glucosamine-induced activation of glycogen biosynthesis in isolated adipocytes. Evidence for a rapid allosteric control mechanism within the hexosamine biosynthesis pathway
    Stephen Marshall
    Hexos, Incorporated, Woodinville, Washington 98072, USA
    J Biol Chem 280:11018-24. 2005
    ..Stimulation of GBS and depletion of UDP-glucose both correlated with an early and rapid rise in the levels of glucosamine-6-phosphate (GlcN-6-P), a known activator of GS...
  55. doi After patients are diagnosed with knee osteoarthritis, what do they do?
    Kelly A Grindrod
    University of British Columbia, Vancouver, British Columbia, Canada
    Arthritis Care Res (Hoboken) 62:510-5. 2010
    ..To learn more about the health services and products that patients use after receiving a diagnosis of knee osteoarthritis (OA), as well as the trajectory of their health-related quality of life (HRQOL)...
  56. pmc Allosteric regulation of glucosamine-6-phosphate deaminase (NagB) and growth of Escherichia coli on glucosamine
    Laura I Alvarez-Añorve
    Institut de Biologie Physico Chimique, UPR9073 CNRS, 13 rue Pierre et Marie Curie, 75005 Paris, France
    J Bacteriol 191:6401-7. 2009
    ..Second, it is the allosteric activator of glucosamine-6P (GlcN6P) deaminase, NagB, and thus increases the catalytic capacity of this key enzyme in the metabolism of ..
  57. ncbi Cloning and characterization of the N-acetylglucosamine operon of Escherichia coli
    K G Peri
    Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada
    Biochem Cell Biol 68:123-37. 1990
    ..in Escherichia coli: enzyme IInag (gene nagE), N-acetylglucosamine-6-phosphate deacetylase (gene nagA), and glucosamine-6-phosphate isomerase (gene nagB). The three genes are located near 16 min on the E. coli chromosome...
  58. doi O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene
    Meishiue Kuo
    Institut Cochin, Universite Paris Descartes, 22 rue Mechain, CNRS UMR 8104, Paris, France
    FEBS Lett 582:829-34. 2008
    Mono-O-glycosylations post-translationally regulate the activity of nucleocytoplasmic proteins. We showed that glucosamine and an inhibitor of deglycosylation (PUGNAc) induced O-glycosylation of FoxO1, resulting in increased expression ..
  59. pmc Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling
    LuYun Zou
    University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Heart Circ Physiol 296:H515-23. 2009
    We have previously demonstrated that in a rat model of trauma-hemorrhage (T-H), glucosamine administration during resuscitation improved cardiac function, reduced circulating levels of inflammatory cytokines, and increased tissue levels ..
  60. ncbi Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial
    Rianne M Rozendaal
    Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Intern Med 148:268-77. 2008
    The effectiveness of glucosamine sulfate as a symptom and disease modifier for osteoarthritis is still under debate.
  61. ncbi Modulation of TNF-alpha-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide
    Yinghua Ju
    Department of Host Defense and Biochemical Research, Juntendo University, School of Medicine, Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int J Mol Med 22:809-15. 2008
    Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action...
  62. ncbi Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats
    Laszlo G Nöt
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Shock 28:345-52. 2007
    We have previously shown that glucosamine administration resulted in higher cardiac output and improved tissue perfusion after trauma-hemorrhage with resuscitation in rats, which was associated with the increased levels of protein O-..
  63. ncbi Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance
    G Veerababu
    Department of Medicine, University of Utah School of Medicine, Veterans Administration Medical Center, Salt Lake City 84132, USA
    Diabetes 49:2070-8. 2000
    ..05) and higher levels of the hexosamine end product UDP-N-acetyl glucosamine (288 +/- 11 pmol/g in transgenic mice vs. 233 +/- 10 pmol/g in controls, P < 0.001)...
  64. ncbi Single dose pharmacokinetics and bioavailability of glucosamine in the rat
    Ali Aghazadeh-Habashi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 5:181-4. 2002
    To study pharmacokinetics of glucosamine following various routes of administration of the hydrochloride salt to rats and locate the site of its first-pass metabolism.
  65. doi The effects of oral glucosamine on joint health: is a change in research approach needed?
    J A Block
    Department of Internal Medicine Rheumatology, Rush University Medical Center, Chicago IL 60612, USA
    Osteoarthritis Cartilage 18:5-11. 2010
    Oral glucosamine (GlcN) has been widely studied for its potential therapeutic benefits in alleviating the pain and disability of osteoarthritis (OA)...
  66. doi Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride
    M Meulyzer
    Departement des Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Osteoarthritis Cartilage 16:973-9. 2008
    To compare the pharmacokinetics of glucosamine and the synovial fluid levels attained following treatment with glucosamine sulphate or glucosamine hydrochloride in a large animal model at clinically relevant doses.
  67. ncbi The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial
    Daren A Scroggie
    Department of Rheumatology, 59th Medical Wing, Wilford Hall Medical Center, Lackland Air Force Base, Lackland, TX 78236, USA
    Arch Intern Med 163:1587-90. 2003
    With increasing use of glucosamine-containing supplements for the treatment of osteoarthritis, there is increasing concern in the medical community about possible toxic effects...
  68. doi Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis
    Joerg Gruenwald
    Analyze and Realize AG, Berlin, Germany
    Adv Ther 26:858-71. 2009
    ..The aim was to see if a combination of glucosamine sulfate (1500 mg/day) and the omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and ..
  69. doi Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training
    S G Petersen
    Institute of Sports Medicine Copenhagen, Faculty of Health Sciences, Bispebjerg Hospital, University of Copenhagen, Denmark
    Osteoarthritis Cartilage 18:34-40. 2010
    ..c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo.
  70. doi Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1 ga, Anam Dong, Seongbuk gu, Seoul 136 705, Korea
    Rheumatol Int 30:357-63. 2010
    The aim of this study was to assess the structural efficacies of daily glucosamine sulfate and chondroitin sulfate in patients with knee osteoarthritis (OA)...
  71. ncbi Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels
    John M Rumberger
    Hexos, Inc, Woodinville, Washington 98072, USA
    J Biol Chem 278:28547-52. 2003
    ..we treated primary cultured adipocytes for 18 h with insulin (25 ng/ml) and either glucose (20 mm) or glucosamine (2 mm)...
  72. ncbi The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs
    Abi Adebowale
    Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
    Biopharm Drug Dispos 23:217-25. 2002
    The purpose of this study was to determine the oral bioavailability and pharmacokinetics of a glucosamine (GL) and the disaccharides of chondroitin sulfate (CS) after single and multiple-dosing of a GL/CS combination (Cosamin, Cosequin).
  73. ncbi Glucosamine
    Stephen Dahmer
    Beth Israel Department of Family Medicine, Beth Israel Center for Health and Healing, New York, New York 10016, USA
    Am Fam Physician 78:471-6. 2008
    b>Glucosamine is one of the most popular dietary supplements sold in the United States. Most clinical trials have focused on its use in osteoarthritis of the knee...
  74. ncbi The effect of glucosamine on Serum HDL cholesterol and apolipoprotein AI levels in people with diabetes
    Stewart G Albert
    Department of Internal Medicine, Division of Endocrinology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Diabetes Care 30:2800-3. 2007
    ..Previously, in vitro treatment of hepatocyte cell lines with glucosamine increased apoAI production by stabilization of apoAI mRNA...
  75. ncbi Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats
    Surjeet Singh
    Department of Pharmacology, Indian Institute of Integrative Medicine, Canal Road Jammu Tawi, Jammu and Kashmir 180001, India
    Bioorg Med Chem Lett 17:3706-11. 2007
    The present study revealed the synergistic effect of boswellic acid mixture (BA) and glucosamine for anti-inflammatory and anti-arthritic activities in rats...
  76. ncbi Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals
    Allison J Tannis
    University of Guelph, Department of Human Biology and Nutritional Sciences, Ontario, Canada
    Osteoarthritis Cartilage 12:506-11. 2004
    To test the hypothesis that glucose intolerance does not occur when healthy adults consume normal, recommended dosages of glucosamine sulfate.
  77. ncbi Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials
    O Bruyere
    Department of Public Health, Epidemiology and Health Economics, University of Liege, Belgium
    Osteoarthritis Cartilage 16:254-60. 2008
    To assess the incidence of Total Joint Replacement (TJR) during the long-term follow-up of patients with knee osteoarthritis (OA) formerly receiving treatment with glucosamine sulphate or placebo.
  78. pmc Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation
    Norbert Fülöp
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, AL 35294 0005, USA
    Am J Physiol Heart Circ Physiol 292:H2227-36. 2007
    We have shown that, in the perfused heart, glucosamine improved functional recovery following ischemia and that this appeared to be mediated via an increase in O-linked N-acetylglucosamine (O-GlcNAc) levels on nucleocytoplasmic proteins...
  79. ncbi Short-term glucosamine infusion does not affect insulin sensitivity in humans
    M J Pouwels
    Divisions of General Internal Medicine, University Medical Center, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 86:2099-103. 2001
    ..Hexosamine pathway activation can be mimicked by glucosamine (GlcN)...
  80. ncbi The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse
    Jianping Du
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 100 Penn Street, AHB 540C, Baltimore, MD 21201, USA
    Biopharm Drug Dispos 25:109-16. 2004
    The purpose of this study was to determine if glucosamine (GL) hydrochloride (FCHG49) and low molecular weight (LMW) chondroitin sulfate (CS) (TRH122) are absorbed after oral administration to horses...
  81. ncbi Effects of oral glucosamine and chondroitin sulfate alone and in combination on the metabolism of SHR and SD rats
    B W Echard
    Department of Physiology and Biophysics, Georgetown University Medical Center Washington, DC 20007, USA
    Mol Cell Biochem 225:85-91. 2001
    b>Glucosamine (G), often combined with chondroitin sulfate (CS), is a popular natural supplement used widely to treat osteoarthritis. However, use of glucosamine has been linked to development of insulin resistance...
  82. ncbi Glucosamine-6-phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design
    Marek Wojciechowski
    Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Gdansk, Poland
    Acta Biochim Pol 52:647-53. 2005
    ..The novel ligand was designed and synthesised. Biological experiments confirmed our predictions. The new compound named ADMP is a much better inhibitor of glucosamine-6-phosphate synthase than ADGP.
  83. pmc BAAV transcytosis requires an interaction with beta-1-4 linked- glucosamine and gp96
    Giovanni Di Pasquale
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e9336. 2010
    ..This identified chitotriose, a trimer of beta-1-4-linked N-acetyl glucosamine, as having an interaction with BAAV...
  84. ncbi Cumulus expansion and glucose utilisation by bovine cumulus-oocyte complexes during in vitro maturation: the influence of glucosamine and follicle-stimulating hormone
    Melanie L Sutton-McDowall
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia 5011, Australia
    Reproduction 128:313-9. 2004
    ..utilisation for synthesis of ECM, bovine cumulus-oocyte complexes (COCs) were matured in +/- FSH and/or glucosamine (an alternative substrate of matrix components)...
  85. ncbi Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils
    Jian Hua
    Department of Biochemistry, Juntendo University, School of Medicine, Tokyo, Japan
    J Leukoc Biol 71:632-40. 2002
    b>Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues...
  86. ncbi The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis
    Susanne X Wang
    University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 56:1537-48. 2007
    ..subchondral bone changes in a rabbit model of experimental osteoarthritis (OA), and to determine the effects of continuous administration of a clinically relevant dose of glucosamine HCl on subchondral bone changes in this model.
  87. doi Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition
    Dae Seok Kim
    Molecular Oncology Branch, Division of Basic and Applied Sciences, Research Institute National Cancer Center, Goyang, Gyeonggi do 410 769, Republic of Korea
    Cancer Lett 273:243-9. 2009
    ..By screening for TGase inhibitors in a natural compound library, we found that glucosamine has a TGase 2 inhibitory effect in vitro...
  88. ncbi Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy
    J W Anderson
    Department of Internal Medicine, University of Kentucky, 1030 South Broadway, Suite 5, Lexington KY 40504 2681, USA
    Food Chem Toxicol 43:187-201. 2005
    b>Glucosamine is widely used to relieve symptoms from osteoarthritis. Its safety and effects on glucose metabolism are critically evaluated in this review...
  89. ncbi Control of gene expression by a natural metabolite-responsive ribozyme
    Wade C Winkler
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520 8103, USA
    Nature 428:281-6. 2004
    ..The ribozyme is activated by glucosamine-6-phosphate (GlcN6P), which is the metabolic product of the GlmS enzyme...
  90. doi Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells
    G A Raciti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy
    Diabetologia 53:955-65. 2010
    b>Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells...
  91. pmc The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis
    Kei Imagawa
    University of Southampton Medical School, Bone and Joint Research Group, Southampton, UK
    Biochem Biophys Res Commun 405:362-7. 2011
    ..modalities include analgesia, joint injection with steroids or hyaluronic acid, oral supplements including glucosamine and chondroitin sulfate, as well as physiotherapy...
  92. ncbi GLUT2 is a high affinity glucosamine transporter
    Marc Uldry
    Institute of Pharmacology and Toxicology, University of Lausanne, 27, Rue du Bugnon, 1005 Lausanne, Switzerland
    FEBS Lett 524:199-203. 2002
    When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V(max) values that are three- to four-fold lower than for glucose. The K(m)s for glucosamine and glucose of GLUT1 and GLUT4 were similar...
  93. doi Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes
    S Toegel
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
    Osteoarthritis Cartilage 16:1205-12. 2008
    To compare the effects of glucosamine (GlcN), curcumin, and diacerein in immortalized human C-28/I2 chondrocytes at the cellular and the gene expression level...
  94. ncbi Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses
    Sheila Laverty
    Faculté de Médicine Vétérinaire, Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 52:181-91. 2005
    To examine the concentration of glucosamine in the synovial fluid and its pharmacokinetics in serum in a large animal model following dosing with glucosamine HCl at clinically relevant levels.
  95. ncbi Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats
    J Hua
    Department of Host Defense and Biochemical Research, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Inflamm Res 54:127-32. 2005
    b>Glucosamine, a naturally occurring amino monosaccharide has been used to treat or prevent osteoarthritis in humans. In this study, we evaluated the effect of glucosamine on rat adjuvant arthritis, a model of rheumatoid arthritis.
  96. ncbi Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate
    O Bruyere
    WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, Liege, Belgium
    Osteoarthritis Cartilage 11:1-5. 2003
    ..To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing...
  97. ncbi Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study
    Karel Pavelka
    Department of Medicine and Rheumatology, Charles University, Prague, Czech Republic
    Arch Intern Med 162:2113-23. 2002
    ..The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously ..
  98. pmc Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta
    Jean Noel Gouze
    Department of Orthopaedics and Rehabilitation, Gene Therapy Laboratory, University of Florida, College of Medicine, PO Box 100137, Gainesville, FL 32610 0137, USA
    Arthritis Res Ther 8:R173. 2006
    The effects of exogenous glucosamine on the biology of articular chondrocytes were determined by examining global transcription patterns under normal culture conditions and following challenge with IL-1beta...
  99. pmc Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: a feasibility trial
    Norman T M Ng
    The University of Queensland, School of Human Movement Studies, Blair Drive, St Lucia Campus, Brisbane, Queensland 4072, Australia
    Arthritis Res Ther 12:R25. 2010
    ..Although walking is commonly recommended for reducing pain and increasing physical function in people with OA, glucosamine sulphate has also been used to alleviate pain and slow the progression of OA...
  100. pmc Glucosamine inhibits epidermal growth factor-induced proliferation and cell-cycle progression in retinal pigment epithelial cells
    Chang Min Liang
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Mol Vis 16:2559-71. 2010
    To investigate the effects and mechanisms of glucosamine (GlcN) on the proliferation of retinal pigment epithelial cells in response to epidermal growth factor (EGF).
  101. ncbi Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
    S Marshall
    Department of Biochemistry, University of Tennessee, Memphis 38163
    J Biol Chem 266:4706-12. 1991
    ..As a second approach, we determined whether glucosamine, an agent known to preferentially enter the hexosamine pathway at a point distal to enzymatic amidation by GFAT,..

Research Grants63

  1. FACTORS THAT MODIFY INSULIN ACTION
    Maria G Buse; Fiscal Year: 2012
    ..to high glucose increases flux via the hexosamine synthesis pathway, enhancing the production of UDP-N-acetyl glucosamine (UDP-GlcNAc), the substrate of O-GlcNAc transferase (OGT)...
  2. Pathogensis of Bacterial corneal infection
    Gerald B Pier; Fiscal Year: 2013
    ..aureus infections, utilizing the poly-N-acetyl glucosamine (PNAG) surface polysaccharide as the active component of a conjugate vaccine, to ameliorate the consequences of ..
  3. Development and validation of a chitin assay for environmental samples
    CHRISTINE ANNE ROGERS; Fiscal Year: 2012
    ..Chitin is an insoluble, long chain polymer of [unreadable]1-4-N-acetyl-D-glucosamine and is a structural component of common indoor organisms such as dust mites, cockroaches, and fungi that are ..
  4. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..SULF2 is secreted by tumor cells into the ECM and desulfates HSPGs at the 6-O position of glucosamine. 6-O sulfation is required for binding of heparin-binding growth factors to HSPGs...
  5. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..to GAS challenge, B lymphocytes produce a large proportion of antibodies recognizing O-linked N-acetyl-D- glucosamine, which can bind self-antigens on beta cells...
  6. Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention
    Emily White; Fiscal Year: 2013
    ..strongest and most consistent findings to date are that only the anti-inflammatory supplements (in particular glucosamine, chondroitin and fish oil/n-3 fatty acids) appear to reduce the risk of several cancers...
  7. Structural and Biochemical Studies of LpxC Inhibition
    Pei Zhou; Fiscal Year: 2012
    Project Summary/Abstract Lipid A (endotoxin) is a glucosamine-based saccharolipid that constitutes the outer monolayer of the outer membrane of Gram-negative bacteria;it is also the active component of lipopolysaccharide that causes life-..
  8. Cohort Study of Glucosamine and Chondroitin Supplement Use and Cancer Risk
    Emily White; Fiscal Year: 2012
    ..b>Glucosamine and chondroitin (G &C), often taken together in a single pill, are the most commonly used specialty (non-..
  9. Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    Joanna Phillips; Fiscal Year: 2013
    ..of a multiplicity of signaling molecules, including Wnts, VEGF, and FGF-1, by acting on the 6O-sulfation of glucosamine (6OS) on heparan sulfate proteoglycans (HSPGs)...
  10. Mechanism of cellulose synthesis and transport across biological membranes
    Jochen Zimmer; Fiscal Year: 2013
    ..The polysaccharides typically found in bacterial biofilms include [unreadable]-1,6 linked N-acetyl-glucosamine, alginate, and cellulose...
  11. REGULATION OF HEPATIC AND PERIPHERAL GLUCOSE METABOLISM
    Ralph A DeFronzo; Fiscal Year: 2013
    ..We postulate that increased hexosamine flux leads to increased skeletal muscle UDP-N-acetyl glucosamine (UDP-GlcNAc) which subsequently is O-linked to cystosolic proteins causing insulin resistance and mitochondrial ..
  12. Epithelial Glycoconjugates as Barriers against Enteric Infections
    Nicholas J Mantis; Fiscal Year: 2013
    ..Fucosyltransferases link fucose to terminal galactose and N-acetyl-glucosamine residues, and thereby mask potential ligands on epithelial surfaces...
  13. Citric acid cycle regulation of exopolysaccharide synthesis in staphylococci
    GREG ALAN SOMERVILLE; Fiscal Year: 2013
    ..Interestingly, PIA and capsule are derived from the same amino sugar (i.e., UDP-N-acetyl-glucosamine. Synthesis of both exopolysaccharides is modulated by the availability of nutrients, oxygen, and iron...
  14. Assembly and Function of the Yeast Spore Wall
    Aaron M Neiman; Fiscal Year: 2013
    ..These layers have two major constituents, chitosan, a glucosamine polysaccharide, and a unique polymer containing the crosslinked amino acid dityrosine...
  15. STIM1 mediated calcium entry: A new paradigm of metabolic regulation of cardiomyo
    John C Chatham; Fiscal Year: 2013
    ..The O-linked attachment of ss-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine residues is rapidly emerging as a key mediator of numerous biological ..
  16. pGlcNAc stimulates wound healing and defensin expression via AKT1
    AMANDA HALEY BUFF; Fiscal Year: 2013
    ..Recent findings show that treatment of cutaneous wounds with poly-N-acetyl-glucosamine (pGlcNAc) nanofibers, a novel polysaccharide material derived from a marine diatom, results in an increased ..
  17. Structure and Function of 3-O-sulfation in Heparan Sulfate
    Jeffrey D Esko; Fiscal Year: 2013
    ..One relatively rare modification to the chains, the addition of sulfate to carbon-3 of glucosamine residues, is poorly understood in terms of its biosynthesis and function...
  18. Heparan sulfate proteoglycans as critical regulators of brain cancer malignancy
    Joanna Phillips; Fiscal Year: 2013
    ..heparan sulfate endosulfatase, actively regulates HSPG-dependent signaling by removing the sulfate from 6-O- of glucosamine (6OS) and liberating protein ligands from HSPG sequestration (5)...
  19. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..features include a replacement of phosphate with galacturonic acid residues, oxidation of the lipid-A proximal glucosamine residue to 2-aminogluconate, and the presence of the very long chain fatty acid, 27- hydroxyoctacosaonic acid (..
  20. Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    Charles J Dimitroff; Fiscal Year: 2012
    ..The effects of over-the-counter glucosamine formulations have been purported to relieve arthritic conditions and are supportive of this notion...
  21. Immunostimulatory properties of chitin and chitosan
    CHARLES ALLEN SPECHT; Fiscal Year: 2012
    ..This is due, in large part, to the heterogeneous mix of glucosamine and N-acetylglucosamine in the polymers, their relative insolubility and frequent contamination of available ..
  22. Site-specific O-GlcNAc MAbs: New Tools for Glycoproteomics
    Ron Orlando; Fiscal Year: 2013
    ..O-glycosylation of serine and threonine of nuclear and cytoplasmic proteins by a single beta-N- acetyl-D-glucosamine moiety (O-GlcNAc) is a ubiquitous post-translational modification that is highly dynamic and fluctuates in ..
  23. Antibiotic Properties of Artificial Agonists for a Bacterial Riboswitch
    JULIANE K STRAUSS SOUKUP; Fiscal Year: 2010
    ..One particular riboswitch (the glmS riboswitch) binds to glucosamine-6-phosphate (GlcN6P), a building block of the cell wall in Gram-positive bacteria, and undergoes self-cleavage ..
  24. O-GlyNAcylation: Novel Mechanism of Estrogen-Induced Vasoprotection
    Suzanne Oparil; Fiscal Year: 2012
    ..modification of proteins induced by three distinct and independent stimuli, 17-[unreadable] estradiol (E2), glucosamine (GlcN) and the selective O-GlcNAcase inhibitor O-(acetamido-2-deoxy-D-glucopyranosylidene) amino-N-..
  25. The role of N-glycosylation on beta-sheet protein folding energetics
    JOSHUA L PRICE; Fiscal Year: 2010
    ..Specifically, the proposed work seeks to provide insight into how a single N-linked N-acetyl-D-glucosamine (GlcNAc) affects the folding energy landscape of the (3-sheet glycoprotein CD2ad in vitro...
  26. Chemical and enzymatic synthesis of multi-domain heparin mimetics
    TIMOTHY OLEARY; Fiscal Year: 2013
    ..We began this project by developed an enzymatic method for adding an N-azidoacetyl glucosamine to the nonreducing end of an oligosaccharide...
  27. Protein O-GlcNAcylation and the regulation of cardiac function
    John C Chatham; Fiscal Year: 2013
    ..The O-linked attachment of ss-N-acetyl- glucosamine (O-GlcNAc) to serine and threonine residues is a highly dynamic post-translational modification of nuclear and ..
  28. Glucosamine and Novel Anolgs for Cartilage Regeneration
    Kevin J Yarema; Fiscal Year: 2013
    ..treatment of osteoarthritis (OA), leveraging tissue engineering and biological signals inspired by the sugar glucosamine (GlcN)...
  29. ANTITUMOR DRUG EFFECTS ON PHOSPHATIDYLINOSITIDE TURNOVER
    JOHANNA STOECKLER; Fiscal Year: 1990
    ..antimetabolites on the agonist- stimulated release of radiolabeled inositol phosphates, diacylglycerol and glucosamine will be determined by Dowex column chromatography, HPLC and TLC methods...
  30. HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
    Michael McNeil; Fiscal Year: 2009
    ..It is biosynthesized in bacteria from glucosamine-6-phosphate (GlcNH2-6P) in 5 steps by 4 different proteins [GlmM, GlmU (bifunctional), MurA, and MurB]...
  31. CHEMOENZYMATIC SYNTHESIS OF HEPARIN SULFATE OLIGOSACCARIDES
    QUIN SHI; Fiscal Year: 2013
    ..Polymeric HS contains the disacchariderepeating units of glucuronic or iduronic acid linked to glucosamine that carry sulfo groups...
  32. CHITIN BIOSYNTHESIS AND THE MOSQUITO PERITROPHIC MATRIX
    Bruce Christensen; Fiscal Year: 2007
    ..It now is known that glutamine synthetase (GS), glucosamine: fructose-6-phosphate amidotransferase (GFAT) and chitin synthase (CS) play major roles in chitin synthesis in ..
  33. Multi-componet Vaccine for Staphylcoccus epidermidis
    Tomas Maira Litran; Fiscal Year: 2009
    ..a multi-layered biofilm depends, in part, on the production of the surface polysaccharide termed poly-N-acetyl-glucosamine (PNAG)...
  34. Structure/function studies of biofilm agents from Aa
    Narayanan Ramasubbu; Fiscal Year: 2009
    ..shown in our studies that DspB depolymerizes exopolysaccharide (PGA) that are made up of -1,6-linked N-acetyl-D-glucosamine and removes biofilms of many Gram negative as well as Gram positive bacterial pathogens...
  35. GLUCOSAMINE IN CARTILAGE HOMEOSTASIS AND DEGRADATION
    ALEXANDER SHIKHMAN; Fiscal Year: 2004
    b>Glucosamine represents one of the most commonly used over-the- counter drugs to treat osteoarthritis. However, the molecular mechanisms involved in the realization of its anti-arthritic activities are still poorly understood...
  36. REGULATION OF GLCNAC-PI DEACETYLATION
    Victoria Stevens; Fiscal Year: 1999
    ..step in GPI biosynthesis, the deacetylation of N-acetylglucosamine-phosphatidylinositol (GlcNAc-PI) to form glucosamine-phosphatidylinositol (GlcN-PI). Using a cell-free system, we have found that this reaction is stimulated by GTP...
  37. Modification of Helicobacter pylori Lipid A
    MICHAEL TRENT; Fiscal Year: 2004
    ..The lipid A of Escherchia coli is a hexa-acylated disaccharide of glucosamine that is substituted at the 1- and 4'- positions with phosphate and glycosylated at the 6' position with two Kdo ..
  38. INHERITED DISORDERS OF HEPATIC BILIRUBIN GLUCORONIDATION
    Namita Roy Chowdhury; Fiscal Year: 2006
    ..of the import of UDP-glucuronic acid (UDPGA) into the ER lumen by the physiological UGT activator, UDP-N-acetyl glucosamine (UDP-gluc-Nac)...
  39. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..The first aim is to identify specific interactions between amelogenins and structural analogs of N-acetyl glucosamine (GlcNAc) and N-acetyl neuraminic acid (NeuAC) and their glycosidic linkages commonly found in mammalian ..
  40. STRUCTURE OF ANTIMITOGENIC MESANGIAL HEPARAN SULFATES
    Aimin Wang; Fiscal Year: 2002
    ..prepared from digests of heparin/HS with the eliminase heparitinase enzymes; 2a) to use RMCs cultured with [3H]glucosamine and [35S]sulfate to label the intact HS proteoglycans and the HS oligosaccharides generated from them via ..
  41. Osteopuncture for OA-Associated Knee Pain & Disability
    Debra Weiner; Fiscal Year: 2005
    ..Opioids have potentially morbid side effects in frail older adults. Glucosamine and chondroitin, intra-articular corticosteroids and hyaluronic acid, and arthroscopic debridement and lavage ..
  42. A Pharmacokinetic Study of glucosamine and chondroitin
    Christopher Jackson; Fiscal Year: 2005
    ..and complementary therapies in the treatment of osteoarthritis is common and particular interest has focused on glucosamine and chondroitin preparations...
  43. GLYCOPROTEIN SHEDDING AND METASTASIS
    BRUCE BOSMANN; Fiscal Year: 1980
    ..Glycoprotein "shedding" will be studied using tumors radiolabeled with fucose and/or glucosamine in vitro, transplantation of cells to animals and following the release of labeled glycoconjugates into the ..
  44. GIARDIA ENCYSTMENT: CONTROL OF GA1NAC SYNTHESIS
    Edward Jarroll; Fiscal Year: 2000
    ..is synthesized from glucose during encystment by the activity of five inducible, nonsedimentable enzymes: Glucosamine 6-phosphate isomerase, GPI, glucosamine 6-phosphate N-acetylase (GlcNPA), phosphoacetylglucosamine mutase (..
  45. MECHANISTIC STUDIES OF PROKARYOTIC MANNOSYLTRANSFERASES
    JON THORSON; Fiscal Year: 2002
    ..these models should lead to altered eukaryotic cell surface glycosylation patterns terminating in N-acetyl-D-glucosamine (GlcNAc) and Man, defining the cell as "non-self" and thus providing therapeutic opportunities...
  46. VIRULENCE AND IMMUNITY TO STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 2000
    ..expressed surface polysaccharide of Staphylococcus aureus chemically characterized as poly-N-succinyl-beta-1-6 glucosamine (PNSG)...
  47. ENZYME INTERMEDIATE STRUCTURES BY NMR
    Michael Smerdon; Fiscal Year: 2002
    ..The project will be extended to include uridine diphosphate N-acetyl-glucosamine enolpyruvyl transferase (UDP-NAG EPT) and 3-deoxy-D-manno-2-octulosonate-8-phosphate (KD08P) synthase...
  48. BIOCHEMISTRY AND MOLECULAR GENETICS OF MITOMYCIN BIOSYNT
    David Sherman; Fiscal Year: 2003
    ..agent is biosynthetically derived from a shikimate pathway metabolite (3-amino-5-hydroxybenzoic acid) and D-glucosamine. In this work, molecular genetic, biochemical and chemical approaches will be used to obtain information on the ..
  49. Reagents to Investigate Glycosylated Macromolecules
    Animesh Nandi; Fiscal Year: 2004
    ..In preliminary studies, we demonstrated the chemical syntheses of peracetylated N-(2-azidoacetyl) glucosamine (peracetylated GIcNAc-azide) and a phosphine capture reagent linked to biotin...
  50. COMPLEX SACCHARIDES OF NORMAL AND CANCER CELL NUCLEI
    Veer Bhavanandan; Fiscal Year: 1980
    ..Nuclei will be isolated from cells labeled with (3H)glucosamine and ionized 35SO4 and the complex saccharides solubilized by treatment with proteolytic enzymes or with ..
  51. REGULATION OF LH BIOSYNTHESIS BY GNRH AND SEX STEROIDS
    David Baldwin; Fiscal Year: 1990
    ..LH subunit biosynthesis will be determined by the incorporation of radiolabeled methionine and glucosamine (or other sugars and sulfate) into LH by immunoprecipitation of samples using an anti-LH antiserum highly ..
  52. EFFICACY OF GLUCOSAMINE/CHONDROITIN SULFATE IN KNEE OA
    DANIEL CLEGG; Fiscal Year: 2000
    The purpose of this contract is to conduct a study to determine the efficacy of glucosamine and glucosamine/chondroitin sulfate in knee osteoarthritis...
  53. SYNTHETIC MONOSACCHARIDES ADJUVANTS FOR HUMAN VACCINES
    David Johnson; Fiscal Year: 2000
    ..were initiated in Phase I on a novel class of synthetic monosaccharide adjuvants known chemically as aminoalkyl glucosamine phosphates (AGPs)...
  54. The Hexosamine Pathway and Diabetic Nephropathy
    Leighton James; Fiscal Year: 2005
    ..maneuvers like overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT), or exposure of MC to glucosamine, upregulates the expression of genes that have been implicated in renal injury; [GFAT is the rate limiting ..
  55. Poly-N-acetyl glucosamine as a vaccine for bacterial pathogens
    Gerald B Pier; Fiscal Year: 2010
    ..goal of this research program is to understand the immunochemical properties of bacterial poly-N-acetyl glucosamine (PNAG) and utilize this information to produce an effective vaccine for multiple Gram-positive and Gram-..
  56. Investigation of Novel Lipid A Structural Features
    MIDDLETON HINCKLEY; Fiscal Year: 2006
    ..It is a hexaacylated disaccharide of glucosamine that is substituted at the 1- and 4'-positions with phosphate...
  57. CYCLIC AMP AND THE SECRETION OF LUTEINIZING HORMONE
    William Evans; Fiscal Year: 1990
    ..In addition, glucosamine incorporation into LH and synthesis of LH will be monitored, the latter via determination of leucine ..
  58. ETHANOL & FAT INDUCED INSULIN RESISTANCE IN THE ELDERLY
    Guenther Boden; Fiscal Year: 1999
    ..3) that in addition to acetyl-CoA, stimulation by insulin of the hexosamine pathway resulting in production of glucosamine, is needed for the full development of the ethanol and fatty acid mediated defect in the glucose transport ..
  59. Role of Heparan Sulfate-Degrading Sulfatases in Pancreatic Adenocarcinomas
    Steven Rosen; Fiscal Year: 2007
    ..enzymes which act on heparan sulfate proteoglycans (HSPGs) to remove a specific sulfation modification (glucosamine-6-O-sulfation)...
  60. Proteasome regulation by O-glycosylation
    JEFFREY KUDLOW; Fiscal Year: 2007
    ..Physiologically inactivated proteasomes from NRK cells treated with high glucose or glucosamine can be reactivated by recombinant O-GlcNAcase, the enzyme that removes this modification...
  61. LYSOSOMAL AND SECRETED IRON-CONTAINING ACID PHOSPHATASES
    R Roberts; Fiscal Year: 1992
    ..more clearly and possibly the region on the molecule that makes it a substrate for the Golgi enzyme N-acetyl D-glucosamine 1-phosphate transferase...
  62. EXPERIMENTAL MODEL OF PNH
    M Medof; Fiscal Year: 1999
    ..is responsible for the first step in the synthesis of the GPI anchor; specifically, the synthesis of N-acetyl glucosamine phosphatidyl inositol. This gene has been localized to the X chromosome...
  63. RENAL PROTEOGLYCANS--EFFECTS OF DIABETES AND HYPERTROPHY
    Elias Meezan; Fiscal Year: 1990
    ..glomeruli and tubles from normal, diabetic ard uninephrectomized animals will be incubated with 35SO4=, 3H-glucosamine and 3H-galactose with or without insulin and IGF's and the labeled proteoglycans from the cell cytoplasm, cell ..