Genomes and Genes
Summary: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Publications310 found, 100 shown here
- Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineeringK Rezwan
Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
Biomaterials 27:3413-31. 2006....
- Porosity of 3D biomaterial scaffolds and osteogenesisVassilis Karageorgiou
Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Biomaterials 26:5474-91. 2005..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
- Bone substitutes: an updatePeter V Giannoudis
Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
Injury 36:S20-7. 2005..We present here an overview of bone grafts and graft substitutes available for clinical applications...
- Third-generation biomedical materialsLarry L Hench
Department of Materials and the Tissue Engineering Centre, Imperial College of Science, Technology and Medicine, University of London, Prince Consort Road, London SW7 2BP, UK
Science 295:1014-7. 2002....
- A tissue engineering approach to bone repair in large animal models and in clinical practiceRanieri Cancedda
Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genova, Italy
Biomaterials 28:4240-50. 2007..In particular, the supply of oxygen and nutrients to the cells in the inner part of the implanted scaffolds remains a major concern, requiring additional investigations...
- The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trialsMarco Esposito
Oral and Maxillofacial Surgery, Cochrane Oral Health Group, School of Dentistry, The University of Manchester, United Kingdom
Int J Oral Maxillofac Implants 21:696-710. 2006..Trials were divided into 3 categories: (1) major vertical or horizontal bone augmentation (or both); (2) implants placed in extraction sockets; (3) fenestrated implants...
- Non-mulberry silk gland fibroin protein 3-D scaffold for enhanced differentiation of human mesenchymal stem cells into osteocytesBiman B Mandal
Department of Biotechnology, Indian Institute of Technology IIT, Kharagpur 721302, West Bengal, India
Acta Biomater 5:2579-90. 2009..The results suggest the suitability of non-mulberry silk-fibroin protein 3-D scaffolds as natural biomaterial for potential in vitro bone-tissue engineering applications...
- Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowthO Gauthier
Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
Biomaterials 19:133-9. 1998..MBCP implants with 565 microm pore diameter and 40% macroporosity represented the optimal association for homogeneous and abundant bone ingrowth...
- Bone regeneration: molecular and cellular interactions with calcium phosphate ceramicsFlorence Barrere
Biomedical Technological Institute BMTI, University ofTwente, Enschede, The Netherlands
Int J Nanomedicine 1:317-32. 2006....
- Collagen-hydroxyapatite composites for hard tissue repairD A Wahl
Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
Eur Cell Mater 11:43-56. 2006..Solid free form fabrication where a mould can be built up layer by layer, providing shape and internal vascularisation may provide an improved method of creating composite structures...
- Bone substitutes in the Netherlands - a systematic literature reviewJohan van der Stok
Department of Surgery Traumatology, Erasmus MC, University Medical Centre Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Acta Biomater 7:739-50. 2011..This has resulted in the development of alternative (synthetic) bone substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of ..
- Osteoinduction by biomaterials--physicochemical and structural influencesPamela Habibovic
Department Bilthoven, Institute for Biomedical Technology, University of Twente, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
J Biomed Mater Res A 77:747-62. 2006....
- Synchrotron X-ray microtomography (on a micron scale) provides three-dimensional imaging representation of bone ingrowth in calcium phosphate biomaterialsP Weiss
Laboratoire de Recherche sur les Matériaux d Intérêt Biologique INSERM 99 03, Faculte de Chirurgie Dentaire, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 01, France
Biomaterials 24:4591-601. 2003..micron scale to compare three-dimensional (3D) bone ingrowth after implantation of various calcium phosphate bone substitutes in a rabbit model...
- Poly (D,L-lactide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluationJie Ren
Institute of Nano and Bio Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, 200092, P R China
J Mater Sci Mater Med 19:1075-82. 2008Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping...
- Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivoFrank M Klenke
Department Clinical Research, Group for Bone Biology and Orthopedic Research, University of Berne, CH 3010 Berne, Switzerland
J Biomed Mater Res A 85:777-86. 2008..15 (+/-0.06) mm(3)]. Similar results were observed for the BIC. The data demonstrates pore size to be a critical parameter governing the dynamic processes of vascularization and osseointegration of bone substitutes.
- Allograft and alloplastic bone substitutes: a review of science and technology for the craniomaxillofacial surgeonBarry L Eppley
Division of Plastic Surgery, Indiana School of Medicine, Indianapolis, Indiana, USA
J Craniofac Surg 16:981-9. 2005....
- Orthopaedic applications of bone graft & graft substitutes: a reviewS K Nandi
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India
Indian J Med Res 132:15-30. 2010..We review the currently available bone graft and graft substitutes for the novel therapeutic approaches in clinical setting of orthopaedic surgery...
- Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbitsXin Xin Shao
Department of Orthopaedic Surgery, National University of Singapore, 10 Lower Kent Ridge Road, Singapore 119260, Singapore
Biomaterials 27:1071-80. 2006....
- Static and dynamic cultivation of bone marrow stromal cells on biphasic calcium phosphate scaffolds derived from an indirect rapid prototyping techniqueM Schumacher
Friedrich Baur Research Institute for Biomaterials, University of Bayreuth, 95440 Bayreuth, Germany
J Mater Sci Mater Med 21:3039-48. 2010..Therefore, scaffolds manufactured from BCP ceramic and seeded with BMSCs using a dynamic culture system are the method of choice for bone tissue engineering...
- The compatibility of ceramic bone graft substitutes as allograft extenders for use in impaction grafting of the femurA W Blom
Department of Orthopaedic Surgery, Bristol Royal Infirmary, Bristol, England, UK
J Bone Joint Surg Br 87:421-5. 2005..There was no statistically significant difference between the four groups after 18 months of unrestricted functional loading for all outcome measures...
- Bone graft substitutesReena A Bhatt
Department of Plastic Surgery, Warren Alpert Medical School of Brown University, The Miriam and Rhode Island Hospitals, 235 Plain Street, Providence, RI 02903, USA
Hand Clin 28:457-68. 2012..Considerations in selecting bone grafts and substitutes include characteristic capabilities, availability, patient morbidity, immunogenicity, potential disease transmission, and cost variability...
- Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: evaluation in vitro using osteoblast-like cells and in vivo in a bone defectSilvia Panseri
Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy
PLoS ONE 7:e38710. 2012....
- Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?Tara L Aghaloo
University of California at Los Angeles UCLA School of Dentistry, Los Angeles, California 90049 6603, USA
Int J Oral Maxillofac Implants 22:49-70. 2007..The aim of this systematic review was to identify the most successful technique(s) to provide the necessary alveolar bone to place a dental implant and support long-term survival...
- Demineralized bone matrix in bone repair: history and useELLIOTT GRUSKIN
Synthes USA, 1302 Wrights Lane East, West Chester, PA 19380, USA
Adv Drug Deliv Rev 64:1063-77. 2012....
- Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat modelBorhane H Fellah
INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
Biomaterials 29:1177-88. 2008..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone ..
- The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D cultureShinichi Maeno
Department of Orthopaedic Surgery, Keio University Hospital, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
Biomaterials 26:4847-55. 2005..Considering the viability of embedded cells, culturing scaffolds in media with Ca2+ concentrations around 5mM is useful for both HAp deposition and osteoblast behavior...
- Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivoShahram Ghanaati
Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
Acta Biomater 6:4476-87. 2010..The data from this study showed that all investigated β-TCP bone substitutes induced the formation of multinucleated giant cells...
- A novel calcium phosphate ceramic-magnetic nanoparticle composite as a potential bone substituteYao Wu
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, People s Republic of China
Biomed Mater 5:15001. 2010..Accordingly, it might be expected that this CaP-MNP composite could become a potential bone substitute or bone tissue engineering scaffold...
- A novel route in bone tissue engineering: magnetic biomimetic scaffoldsN Bock
Istituto per lo Studio dei Materiali Nanostrutturati ISMN CNR, Via P Gobetti 101, Bologna 40129, Italy
Acta Biomater 6:786-96. 2010..Hence, this new type of scaffold is a valuable candidate for tissue engineering applications, featuring a novel magnetic guiding option...
- Tissue engineering of bone: material and matrix considerationsYusuf Khan
University of Virginia School of Medicine, 400 Ray C Hunt Drive, Charlottesville, VA 22908, USA
J Bone Joint Surg Am 90:36-42. 2008....
- Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisationV Maquet
Centre for Education and Research on Macromolecules, University of Liege, Belgium
Biomaterials 25:4185-94. 2004..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
- 3D microenvironment as essential element for osteoinduction by biomaterialsPamela Habibovic
Institute for Biomedical Technology, Twente University, Department Bilthoven, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
Biomaterials 26:3565-75. 2005....
- Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphateYoshitake Takahashi
Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Biomaterials 26:4856-65. 2005..These results suggest that the maintenance of the intrasponge space necessary for the osteoinduction is one factor contributing to the osteoinduction extent of BMP-2-incorporating sponges...
- The in-vitro bioactivity of mesoporous bioactive glassesXiaoxia Yan
Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China
Biomaterials 27:3396-403. 2006..According to our results, MBGs calcined at 973K may possess the best in vitro bioactivity. The influences of the composition and calcination temperature upon bioactivity are explained in terms of the unique structures of MBGs...
- Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substratesAnand S Badami
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0211, USA
Biomaterials 27:596-606. 2006..These studies show that topographical factors designed into biomaterial scaffolds can regulate spreading, orientation, and proliferation of osteoblastic cells...
- Ridge preservation with the use of Bio-Oss collagen: A 6-month study in the dogMauricio G Araújo
Department of Dentistry, State University of Maringa, Parana, Brazil
Clin Oral Implants Res 20:433-40. 2009..In previous short-term studies, it was observed that while the placement of biomaterial in alveolar sockets may promote bone formation and ridge preservation, the graft may in fact also delay healing...
- Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loopUlrich Kneser
Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Erlangen, Germany
Tissue Eng 12:1721-31. 2006..Our aim was to induce axial vascularization in a processed bovine cancellous bone (PBCB) matrix using an arteriovenous (AV) loop (artery, vein graft, and vein)...
- A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formationT Livingston Arinzeh
Osiris Therapeutics, Inc, Baltimore, MD, USA
Biomaterials 26:3631-8. 2005..In vitro studies also demonstrated that 20/80 HA/TCP stimulated the osteogenic differentiation of hMSCs as determined by the expression of osteocalcin...
- The use of bone-graft substitutes in large bone defects: any specific needs?G M Calori
COR, Orthopaedic Institute, G Pini, University of Milan, Italy
Injury 42:S56-63. 2011..Research is on-going for the development of alternative bone substitutes of both biological and synthetic origin...
- Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibilityHockin H K Xu
Paffenbarger Research Center, American Dental Association Foundation, USA
Biomaterials 26:1337-48. 2005..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
- Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam meltingPeter Heinl
University of Erlangen Nuremberg, Department of Materials Science Institute of Science and Technology of Metals, Martensstrasse 5, 91058 Erlangen, Germany
Acta Biomater 4:1536-44. 2008..The modified bioactive surface is expected to enhance the fixation of the implant in the surrounding bone as well as to improve its long-term stability...
- Bone substitutes in vertebroplastyP F Heini
Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
Eur Spine J 10:S205-13. 2001..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
- The effect of biomimetic apatite structure on osteoblast viability, proliferation, and gene expressionYu Fen Chou
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
Biomaterials 26:285-95. 2005..The results of this study suggest differential cell responses to subtle changes in apatite microenvironment...
- Development of biomimetic nano-hydroxyapatite/poly(hexamethylene adipamide) compositesXuejiang Wang
Institute of Materials Science and Technology, Sichuan University, 610064 Chengdu, China
Biomaterials 23:4787-91. 2002..Chemical binding between inorganic n-HA and polyamide was investigated and discussed. The mechanical properties of the composites were found to match well with those of natural bone...
- Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop modelJustus P Beier
Department of Plastic and Hand Surgery, University Hospital of Erlangen, Erlangen, Germany
J Tissue Eng Regen Med 4:216-23. 2010....
- Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineeringGuobao Wei
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2009, USA
Biomaterials 25:4749-57. 2004..The results suggest that the newly developed NHAP/polymer composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering...
- Bone graft substitutes: past, present, futureS N Parikh
Department of Orthopaedics, Children s Hospital Medical Centre, University of Cincinnati, OH 45229, USA
J Postgrad Med 48:142-8. 2002..The main purpose of this article is to give the reader an idea about the existing market products and products likely to be available in near future...
- Osteoinduction of porous bioactive titanium metalShunsuke Fujibayashi
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
Biomaterials 25:443-50. 2004..This finding may elucidate the nature of osteoinduction, and lead to the advent of epochal osteoinductive biomaterials for tissue regeneration...
- Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep musclesDamien Le Nihouannen
INSERM EM9903, Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery of Nantes, Place Alexis Ricordeau, 44042 Nantes, France
Bone 36:1086-93. 2005..The different hypotheses explaining ectopic bone formation induced by MBCP granules are discussed. Synthetic bone substitutes with osteoinductive properties could be used in bone reconstructive surgery.
- Nanosized and nanocrystalline calcium orthophosphatesSergey V Dorozhkin
Kudrinskaja sq 1 155, Moscow 123242, Russia
Acta Biomater 6:715-34. 2010..The review also provides possible directions for future research and development...
- In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect modelN Patel
Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Cambridge, CB2 3QZ, UK
J Mater Sci Mater Med 16:429-40. 2005....
- Closure of rabbit calvarial critical-sized defects using protective composite allogeneic and alloplastic bone substitutesAlbert J Haddad
Orthobiologics Laboratory and Oral and Maxillofacial Surgery, University of Toronto, Toronto, Ontario, Canada
J Craniofac Surg 17:926-34. 2006..cranial vault defects in thirty New Zealand white rabbits using various allogeneic and alloplastic bone substitutes designed to provide mechanical protection to the brain as well as osteoinductivity...
- Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sinteringJessica M Williams
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
Biomaterials 26:4817-27. 2005....
- Bone formation and resorption of highly purified beta-tricalcium phosphate in the rat femoral condyleNaoki Kondo
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 1, Asahimachi Dori, Niigata 951 8510, Japan
Biomaterials 26:5600-8. 2005..beta-TCP has a good biocompatibility since both bioresorption and bone formation started at an early stage after implantation...
- Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone graftsYefang Zhou
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 119260, Singapore
Biomaterials 28:814-24. 2007....
- Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of boneE Garreta
Barcelona Bioengineering Center, Institut Quimic de Sarria, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain
Biomol Eng 24:75-80. 2007..We have observed that the mESC can be induced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particles into the nanofiber scaffold...
- Single-level cervical radiculopathy: clinical outcome and cost-effectiveness of four techniques of anterior cervical discectomy and fusion and disc arthroplastyArup K Bhadra
Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP, UK
Eur Spine J 18:232-7. 2009..Single-level cervical radiculopathy was treated with four different techniques. The clinical outcome and cost-effectiveness were compared in this study...
- A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pigWerner Gotz
Dept of Orthodontics, Oral Biology Laboratory, University of Bonn, Dental Hospital, Bonn, Germany
Folia Histochem Cytobiol 48:589-96. 2010..The results of this preliminary study indicate that this biomaterial has osteoinductive potential and induces the formation of bone structures, mainly in subcutaneous adipose tissue in the pig...
- Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrierPhilip Kasten
Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr 200A, 69118 Heidelberg, Germany
Biomaterials 26:5879-89. 2005..Ectopic bone formation in the novel biomaterial CDHA varied considerably with the cell pool and was at least equal to beta-TCP blocks...
- Impaction bone grafting of the acetabulum at hip revision using a mix of bone chips and a biphasic porous ceramic bone graft substituteAshley W Blom
Department of Academic Orthopaedics, University of Bristol, BIRC Research Labs, Avon Orthopaedic Centre, Bristol
Acta Orthop 80:150-4. 2009..Previous in vitro and in vivo studies have yielded good results using mixtures of allograft and BoneSave, when compared with allograft alone. This study is the first reported human clinical trial of BoneSave in impaction grafting...
- Reduced adhesion of macrophages on anodized titanium with select nanotube surface featuresAmancherla Rajyalakshmi
Non Ferrous Materials Technology Development Centre, Hyderabad, India
Int J Nanomedicine 6:1765-71. 2011..This in vitro study thus demonstrated a reduced density of macrophages on anodized Ti, thereby providing further evidence of the greater efficacy of anodized Ti for orthopedic applications...
- Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatiteMichael Thorwarth
Department of Oral and Maxillofacial Surgery Plastic Surgery, University of Jena, Erlanger Allee 101, D 07747 Jena, Germany
J Oral Maxillofac Surg 63:1626-33. 2005..The regenerative potentials of the tested materials were compared with each other...
- Histologic analysis of allograft mixed with hydroxyapatite-tricalcium phosphate used in revision femoral impaction bone graftingTakaaki Fujishiro
Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
Orthopedics 31:277. 2008....
- Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using 3D-nano-CTVolker Alt
Department of Trauma Surgery, Justus Liebig University Giessen, Germany
Acta Biomater 7:3773-9. 2011..8) but not with the dimension of the fracture zone (r=0.3). Nano-CT imaging is feasible for quantitative analysis of angiogenesis during bony integration of biomaterials and a promising tool in this context for the future...
- In vivo performance of bilayer hydroxyapatite scaffolds for bone tissue regeneration in the rabbit radiusTeja Guda
Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Fort Sam Houston, TX 78234, USA
J Mater Sci Mater Med 22:647-56. 2011....
- Impaction grafting of the acetabulum with a mixture of frozen, ground irradiated bone graft and porous synthetic bone substitute (Apapore 60)I McNamara
Department of Orthopaedics, West Suffolk Hospital, Bury St Edmunds, UK
J Bone Joint Surg Br 92:617-23. 2010..Longer follow-up will be required to establish whether this technique is as effective as using fresh-frozen allograft...
- Characterization of a bovine collagen-hydroxyapatite composite scaffold for bone tissue engineeringC V M Rodrigues
Programa de Engenharia Metalurgica e de Materiais, COPPE, UFRJ, 21945 970 Rio de Janeiro, RJ, Brazil
Biomaterials 24:4987-97. 2003..The biocomposite studied has several characteristics considered as ideal for its use as a scaffold for osteoconduction and osteoinduction...
- Osteotomy of distal radius fracture malunion using a fast remodeling bone substitute consisting of calcium sulphate and calcium phosphateAntonio Abramo
Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden
J Biomed Mater Res B Appl Biomater 92:281-6. 2010..A more rigid fixation may improve the radiographic outcome with this kind of bone substitute...
- Cost comparison of femoral head banking versus bone substitutesHon Bong Leung
Department of Orthopaedics and Traumatology, Queen Mary Hospital, Pokfulam, Hong Kong
J Orthop Surg (Hong Kong) 18:50-4. 2010To compare the costs of femoral head banking versus bone substitutes.
- Bioresorbability, porosity and mechanical strength of bone substitutes: what is optimal for bone regeneration?Gerjon Hannink
Orthopaedic Research Laboratory, Department of Orthopaedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Injury 42:S22-5. 2011..It is known that intrinsic material properties of CaP bone substitutes have a profound effect on their mechanical and biological behaviour and associated biodegradation...
- Inorganic materials for bone repair or replacement applicationsAudrey Hertz
University of Kent, Department of Biosciences, Canterbury, CT2 7NJ, UK
Nanomedicine (Lond) 2:899-918. 2007....
- Endocultivation: 3D printed customized porous scaffolds for heterotopic bone inductionStephan T Becker
Department of Oral and Maxillofacial Surgery, Christian Albrechts University Kiel, Germany
Oral Oncol 45:e181-8. 2009..Further studies should explore if the stability of the individually designed blocks is sufficient to cultivate larger replacements without an external matrix for support...
- The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate cerShahram Ghanaati
Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
Biomed Mater 7:015005. 2012..Both of these factors are necessary for successful bone tissue regeneration...
- Effect of beta-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humansChristine Knabe
Department of Experimental Dentistry, Campus Benjamin Franklin, Charite University Medical Center Berlin, Abmannshauser Strasse 4 6, D 14197 Berlin, Germany
Biomaterials 29:2249-58. 2008..Consequently, a greater porosity appears to be advantageous for enhancing bone formation and particle degradation...
- Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical propertiesM Schumacher
Friedrich Baur Research Institute for Biomaterials, University of Bayreuth, 95440, Bayreuth, Germany
J Mater Sci Mater Med 21:3119-27. 2010..This strength level is within and above the range of human cancellous bone. Therefore, this technique is well suited to manufacture scaffolds for bone tissue engineering...
- Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineeringMoncy V Jose
Department of Materials Science and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Acta Biomater 5:305-15. 2009..The mechanical behavior showed a sinusoidal trend with a slight decrease in modulus by week 1 due to the plasticizing effect of the medium followed by an increase due to shrinkage, and a subsequent drop by week 6 due to degradation...
- The efficacy of Biobon and Ostim within metaphyseal defects using the Göttinger MinipigChristian K G Spies
Klinik für Orthopädie und Unfallchirurgie, Universitatsklinikum Aachen, Pauwelsstr 30, 52074, Aachen, Germany
Arch Orthop Trauma Surg 129:979-88. 2009To compare bio, osteocompatibility, rate of resorption and remodeling dynamics of two clinically used bone substitutes.
- Nano-hydroxyapatite/poly(L-lactic acid) composite synthesized by a modified in situ precipitation: preparation and propertiesC Y Zhang
Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, People s Republic of China
J Mater Sci Mater Med 21:3077-83. 2010..This supports the potential of these composites for applications in bone tissue engineering and load bearing bone defects repair...
- Bone graft substitutes: What are the options?Haralambos Dinopoulos
Academic Department of Trauma and Orthopaedic Surgery, Clarendon Wing, Floor A, Great George Street, Leeds General Infirmary, LS1 3EX Leeds, UK
Surgeon 10:230-9. 2012..In this review, we summarise the available bone grafting materials, focussing mainly on the various bone substitutes and their characteristics, in an effort to specify the indications for their use.
- Selective bone cell adhesion on formulations containing carbon nanofibersRachel L Price
Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
Biomaterials 24:1877-87. 2003..Moreover, greater weight percentages of high surface energy carbon nanofibers in the PCU/CNF composite increased osteoblast adhesion while at the same time decreased fibroblast adhesion...
- The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissueTakatoshi Okuda
Department of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
Biomaterials 28:2612-21. 2007..These results showed that the microstructure of beta-TCP affects the activity of bone cells and subsequent bone replacement...
- The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repairYang Cui
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, People s Republic of China
Acta Biomater 5:2680-92. 2009..All the data extrapolated that the composite with 10 and 20wt.% op-HA exhibited better comprehensive properties and were the optimal composites for bone repairing...
- Augmentation of bone defect healing using a new biocomposite scaffold: an in vivo study in sheepU van der Pol
AO Research Institute, Clavadelerstrasse 8, Davos, Switzerland
Acta Biomater 6:3755-62. 2010....
- The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction graftingJ J Chris Arts
Orthopaedic Research Laboratory, Department Orthopaedics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Biomaterials 27:1110-8. 2006..In conclusion, Ostim HA-paste could be a valuable addition when TCP-HA ceramic granules are being used for acetabular bone impaction grafting procedures...
- Resorbability of bone substitute biomaterials by human osteoclastsArndt F Schilling
Department of Trauma, Hand, and Reconstructive Surgery, Center for Biomechanics, Hamburg University School of Medicine, Martinistrasse 52, Hamburg 20246, Germany
Biomaterials 25:3963-72. 2004..So far the only way to test this biological property of bone substitutes are animal experiments with all their limitations like ethics, costs and limited transferability to man...
- Immunoexpression of Cbfa-1/Runx2 and VEGF in sinus lift procedures using bone substitutes in rabbitsLeandro Soeiro de Souza Nunes
Department of Health Sciences, Discipline of Oral and Maxillofacial Surgery, School of Dentistry, Sagrado Coracao University, USC, Bauru, Sao Paulo, SP, Brazil
Clin Oral Implants Res 21:584-90. 2010..To analyze and compare the expression of core binding factor-1 (Cbfa-1)/Runx2 and vascular endothelium growth factor (VEGF) in sinus lift procedures using bovine hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP)...
- Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experimentJoerg Wiltfang
Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
Clin Oral Implants Res 15:187-93. 2004..An animal study was carried out to investigate the influence of platelet-rich plasma (PRP) on the regeneration of bony defects...
- Formation of osteoclast-like cells on HA and TCP ceramicsR Detsch
BioCer Entwicklungs GmbH, 95447 Bayreuth, Germany
Acta Biomater 4:139-48. 2008..On the other hand, highly soluble calcium phosphate ceramics like TCP seem to be inappropriate for osteoclast resorption because they produce a high calcium concentration in the osteoclast interface and in the environment...
- Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regenerationFangfang Sun
Department of Nanomedical Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Miryang 627 706, Republic of Korea
Acta Biomater 7:3813-28. 2011..Finally, we provide a summary and our own perspectives on this active area of research...
- Regenerative treatment of peri-implantitis using bone substitutes and membrane: a systematic reviewPhilipp Sahrmann
Clinic for Preventive Dentistry, Periodontology and Cariology, Center for Dental and Oral Medicine, University of Zurich, Plattenstrasse 11, Zurich, Switzerland
Clin Implant Dent Relat Res 13:46-57. 2011..This systematic review aimed to assess the available literature for regenerative treatment of peri-implantitis using bone graft substitutes and membranes...
- Biologically inspired rosette nanotubes and nanocrystalline hydroxyapatite hydrogel nanocomposites as improved bone substitutesLijie Zhang
Division of Engineering, Brown University, Providence, RI 02912, USA
Nanotechnology 20:175101. 2009..In summary, the presently observed excellent properties of the biomimetic nanocrystalline HA/HRN hydrogel composites make them promising candidates for further study for bone tissue engineering applications...
- Autogenous bone grafts and bone substitutes--tools and techniques: I. A 20,000-case experience in maxillofacial and craniofacial surgeryP Tessier
Miami Children s Hospital, Miami, FL 33155, USA
Plast Reconstr Surg 116:6S-24S; discussion 92S-94S. 2005Alloplastic bone substitutes can be used to alter facial contour. In contrast, autogenous bone grafts have a successful 80-year history of restoring facial contour as well as the basic functional support of the craniofacial skeleton...
- Bone substitutes and growth factors as an alternative/complement to autogenous bone for grafting in implant dentistryMats Hallman
Periodontol 2000 47:172-92. 2008
- Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigsSimon Storgård Jensen
Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Bern, Switzerland
Clin Oral Implants Res 17:237-43. 2006The purpose was to qualitatively and quantitatively compare the bone formation and graft resorption of two different bone substitutes used in both orthopedic and oral surgery, with autogenous bone as a positive control.
- A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterizationA M Ambrosio
Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Mater Res 58:295-301. 2001..Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications...
- Comparative performance of three ceramic bone graft substitutesKarin A Hing
IRC in Biomedical Materials, Queen Mary University of London, London, United Kingdom
Spine J 7:475-90. 2007..There is, however, a lack of comparative performance data regarding the relative efficacy of these materials when placed in an osseous defect site...
- Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect modelWilliam R Walsh
Surgical and Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, L1 Clinical Sciences Building, Sydney 2031, Australia
Biomaterials 29:266-71. 2008..Vitoss resorbed faster than the other materials and is likely to differences in particle geometry, pore structure and interconnectivity...
- Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutesYouzhuan Xie
Department of Orthopaedics, Ninth People s Hospital, Shanghai Second Medical University, 200011, Shanghai, China
Eur Spine J 15:1196-203. 2006Few histological studies on bone substitutes in human cervical spine are available and the biological processes of bone substitutes are not well documented...
- Comparative in vivo study of six hydroxyapatite-based bone graft substitutesPamela Habibovic
University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
J Orthop Res 26:1363-70. 2008....
- Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysisWilliam G De Long
Department of Orthopaedic Surgery, Temple University, One Greentree Centre, Suite 104, Marlton, NJ 08053, USA
J Bone Joint Surg Am 89:649-58. 2007
- Nanostructured biomaterials for tissue engineering boneThomas J Webster
Division of Engineering and Orthopaedics, Brown University, Providence, RI 02912, USA
Adv Biochem Eng Biotechnol 103:275-308. 2007..Such advances were previously unimaginable with conventional materials possessing large micron-sized particulates...
- Correlating and Quantifying Mechanically-induced Bone Cell MicrodamageMarnie M Saunders; Fiscal Year: 2012..these conditions, as well as improving fracture healing and distraction osteogenesis outcomes, developing bone substitutes for tissue engineering, and improving implant designs...
- Studies of Chondroyte MaturationCristina C Teixeira; Fiscal Year: 2010....
- Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tagHANNE GRON; Fiscal Year: 2010..The use of Affinergy's proprietary peptides therefore provides effective leverage toward the near doubling of the orthobiologics market. ..
- Functional Fluid Flow Regulated Bone RegenerationYi Xian Qin; Fiscal Year: 2013..Tissue engineering approaches show promise as bone substitutes, and have been particularly successful in vitro in a bioreactor environment...
- Enhanced coupling of bone regenerative peptides to hydroxyapatite-containing biomBonnie K Culpepper; Fiscal Year: 2012..The proposed research will not only facilitate the development of effective bone substitutes but will also have broad impact, given that the E7 domain is expected to increase anchoring of a wide variety ..
- Engineering of Vascularized BoneJeremy J Mao; Fiscal Year: 2012..Current bone substitutes such as hydroxyapatite and grafts are below the surgeon's expectations...
- Bone Tissue Engineerig: Effect of Dynamic PerfusionAaron Goldstein; Fiscal Year: 2009..defects, but limited tissue availability and concerns of donor-site complications drive a growing demand for bone substitutes for reconstructive procedures...
- Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental ApplicationsHANNE GRON; Fiscal Year: 2007..In this project, we are attempting to improve synthetic bone substitutes with Affinergy's linker peptides...
- MECHANICALLY GUIDED TISSUE REGENERATIONSteven Goldstein; Fiscal Year: 2002..and local delivery of biologic factors in stimulating the repair and incorporation of tissue engineered bone substitutes. The models in both a cranial-facial and long bone site utilize specifically designed external fixators which ..
- REGULATED OSTEOINDUCTIVE PLASMID GENE TRANSFER VIA GENEKEVIN RICE; Fiscal Year: 2002..While likely beyond the scope of the present application, a long term goal will be to measure the efficacy of rationally pre-designed GAM constructs in vivo using established bone defect animal models. ..
- OSTEOCLAST REGULATION & OSSEOINTEGRATION OF BIOIMPLANTSPeter Hauschka; Fiscal Year: 2002..Rigid, mineralized bone substitutes are clinically important to avoid patient morbidity in craniofacial and spinal surgery...
- Bioengineering Annulus Fibrosus using Silk ScaffoldRita Kandel; Fiscal Year: 2006..The viability and mechanical properties of the tissue will be evaluated. ..
- TANTALUM FOAMS FOR CANCELLOUS BONE IMPLANTSRichard Kaplan; Fiscal Year: 1992....
- Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental ApplicationsHANNE GRON; Fiscal Year: 2009..In this project, we are attempting to improve synthetic bone substitutes with the Affinergy linker peptides...
- Intl Symposium - Biphasic Calcium Phosphate BiomaterialsRacquel LeGeros; Fiscal Year: 2001....
- COMPOSITE MATERIALS FOR HARD TISSUE REPLACEMENTSILVIA LUEBBEN; Fiscal Year: 2000..During the last few years much research has been devoted to the development of bone substitutes that eventually degrade to allow re-growth of the natural bone...
- BIOMATERIAL APPLICATIONS OF COLLAGEN SPONGEMilos Chvapil; Fiscal Year: 1980..In three models of bone defect (humerus in rabbits, spine fusion in dogs and mastoid cavity obliteration in guinea pigs) CS promoted fibrotic replacement of the tissue defect. ..
- In vivo utilization of Runx2 isoforms during skeletal developmentJulie Liu; Fiscal Year: 2007..promoters and thus drive osteoblast growth and differentiation and 2) to employ this knowledge to engineer bone substitutes that promote faster healing by mimicking the natural processes of the body...
- Biodegradable Scaffolds for Periodontal Void-FillingDEBRA TRANTOLO; Fiscal Year: 2001..2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in the ever-growing market. ..
- Biodegradable Bone Graft ExtenderDEBRA TRANTOLO; Fiscal Year: 2001..If autogenous grafts could be easily extended via a resorbable osteoconductive material, market acceptance would follow. ..
- Biodegradable Bone Graft ExtenderDavid Hile; Fiscal Year: 2004..abstract_text> ..
- NANO-HYDROXYAPATITE IN BIOPOLYMERIC SCAFFOLDS FOR BONEDEBRA TRANTOLO; Fiscal Year: 2002..There are over 450,000 bone graft procedures annually in the U.S. (2.2 million worldwide) with a market potential of $400 to $600 million. New tissue engineered bone replacement materials would find a niche in this ever growing market. ..
- REGENERATION WITH PDGF TREATED OSTEOCONDUCTIVE MATERIALSSamuel Lynch; Fiscal Year: 2001..Certain Bone substitutes have also been shown to enhance periodontal regeneration in both animal models and in humans...
- Conducting Biomaterials for Nerve RegenerationSILVIA LUEBBEN; Fiscal Year: 2001..TDA's soluble conducting polymer could also have non-biomedical applications as an antistatic material, for EMI-shielding, in electronic components and radar-absorbing materials. ..
- A Novel Osteoinductive Molecule in Bone RegenerationChia Soo; Fiscal Year: 2005..Our long term goal is to develop an effective autograft bone substitute. ..
- Bioactive Resorbable Putty Graft and Formable PlatesMaurice Valen; Fiscal Year: 2001..We feel the development of these new bone substitutes and regenerative materials will result in numerous commercial products that are better than any currently ..
- THREE DIMENSIONAL SCAFFOLDS FOR BONE TISSUE ENGINEERINGJOSEPH STANCO; Fiscal Year: 2000..S. to promote growth of bone with bone grafts or bone substitutes. Currently available bone substitutes are far from ideal and have many associated problems...
- NANO-HYDROXYAPATITE SCAFFOLDS TO FILL PERIODONTAL VOIDSDEBRA TRANTOLO; Fiscal Year: 2001..2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in this ever-growing market. ..
- Composite HA-Alumina Implants with Biomimetic PropertiesEUGENIE EMORY; Fiscal Year: 2001..PROPOSED COMMERCIAL APPLICATIONS: Bone substitutes are necessary to help repair or replace damaged, diseased, or missing bone tissue...
- FABRICATION OF ORAL & MAXILLOFACIAL BIOCERAMIC STUCTURESEUGENIE EMORY; Fiscal Year: 2001..proposed commercial application: not available ..
- Helical Rosette Nanotubes for Treating Osteoporotic BoneThomas Webster; Fiscal Year: 2008..abstract_text> ..
- MINERALIZATION OF POLYMERIZED PHOSPHOLIPID ASSEMBLIESPHILLIP MESSERSMITH; Fiscal Year: 2001..medical and dental applications of this technology include th remineralization of incipient caries, treatment of hypersensitive dentin, and as a bone substitute material. ..
- Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth FactorArun Gosain; Fiscal Year: 2007..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
- A Unified Surgical Instrument System for Periodontal Minimally Invasive SurgerySTEPHEN HARREL; Fiscal Year: 2007..The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS. [unreadable] [unreadable] [unreadable]..
- The Role of VDR in PTH and Vitamin D3(D3) SynergyTara Aghaloo; Fiscal Year: 2008..These studies will help understand the mechanisms of PTH and D3 synergy through VDR and their effects on osteoblastic differentiation and function. [unreadable] [unreadable] [unreadable]..
- GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPYTimothy Damron; Fiscal Year: 2008..abstract_text> ..
- Staining Techniques for Micro-CT Imaging of MicrodamageRYAN ROEDER; Fiscal Year: 2004..4. Image the three-dimensional damage developed in cortical bone specimens following low cycle fatigue in four point bending. Differences in damage patterns due to pure bending and combined bending and shear loading will be identified. ..
- Novel Biodegradable Materials for Tissue EngineeringCato Laurencin; Fiscal Year: 2008..Specific Aim 3: To perform biological evaluation of novel blends of polyphosphazenes with PLAGA using in vivo animal models. ..
- Infusion of Particles at Implant interfecesStuart Goodman; Fiscal Year: 2006..abstract_text> ..
- Rabbit Model for In Vivo Monitoring of Bone StructureMichael Voor; Fiscal Year: 2003..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
- THE UBIQUITIN-PROTEOSOME PATHWAY AND BMP-2 EXPRESSIONGregory Mundy; Fiscal Year: 2008..abstract_text> ..
- Devices for Treating Inflammatory Bone Loss in an Oral EnvironmentDavid A Puleo; Fiscal Year: 2010..This project will develop multifunctional, unitary, controlled release devices that halt the detrimental processes and stimulate localized tissue repair in sites compromised by bacteria. ..
- Novel DNA Delivery via Surface Bound Calcium PhosphatesJian Tan; Fiscal Year: 2008..The technology developed in this proposal will have important impact on basic research, biotech industry and gene therapy based medicine. [unreadable] [unreadable] [unreadable]..
- 2005 Biomaterials Gordon ConferenceKEVIN HEALY; Fiscal Year: 2005..A number of leading scientists and engineers from companies working in the biomaterials and tissue engineering area will also be recruited to participate. ..
- Gli Control of PTH-rP and Osteolysis in Breast CancerGregory Mundy; Fiscal Year: 2009..We propose therefore that the Gli family of transcriptional regulators represents an important molecular pathway that regulates PTH-rP expression in breast cancer cells, and subsequent breast cancer-mediated osteolysis. ..
- Bisphosphonates and Oral Complications of Cancer Chemotherapy: A Pilot StudyRegina Landesberg; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- BIOMIMETIC HYDROGELS FOR BONE REGENERATIONKEVIN HEALY; Fiscal Year: 2004....
- Revision THA Impaction Grafts:Effects of Bone FusionAnneliese Heiner; Fiscal Year: 2003..Successful conclusion of the proposed research will provide biomechanical data that will assist in the optimization of the impaction grafting process, thus improving the clinical success rate of this evolving procedure. ..
- Fatigue Crack Morphology in Cemented HipsAmos Race; Fiscal Year: 2002....
- Gene Therapy for Musculoskeletal RepairCato Laurencin; Fiscal Year: 2004..abstract_text> ..
- Student Travel Support for Regenerate 2005Robert Guldberg; Fiscal Year: 2005..The second forum will be a Stem Cell Workshop focused on advances in stem cell research. ..
- PATIENT ORIENTED RESEARCH--ORAL AND MAXILLOFACIAL SURGERTHOMAS DODSON; Fiscal Year: 2004..This award leverages the PI's skills and talents by providing protected time to mentor additional trainees and to conduct high quality patient-oriented research. ..
- Maturational changes in superficial zone chondrocytesChisa Hidaka; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Effect of Femoral Stem Design om Cement Mantle FailureAmos Race; Fiscal Year: 2006..Should these aims be met, the proposed model will be of great use in pre-clinical testing of novel cemented stem designs. ..
- Nanopatterned Surfaces to Control Cell FateKEVIN HEALY; Fiscal Year: 2006..abstract_text> ..
- IVth Intl Conference on Cancer-Induced Bone DiseasesGregory Mundy; Fiscal Year: 2004..Attention will also be given to current diagnostic methods for patients with these skeletal complications of malignancy. ..
- Effects of the Mevalonate Pathway on Bone FormationGregory Mundy; Fiscal Year: 2007..unreadable] [unreadable]..
- Prospective evaluation of immediate temporized implantsMichael Block; Fiscal Year: 2007..Standardized hard and soft tissue data will be collected preextraction as baseline, and then prospectively for at least two years in this trial, to compare and contrast the methods. ..
- Vascularization and Bone RepairRobert Guldberg; Fiscal Year: 2007..Furthermore, the developed methodologies will have broad applicability to other research areas, including for example studies on fracture healing, skeletal development, vascular injury, and tumorigenesis. ..
- Polymer/Ceramic Composites for Tissue EngineeringCato Laurencin; Fiscal Year: 2009..Specific Aim 3: Evaluation of the biological performance of novel 3-D composite matrices using in vivo techniques. ..
- Novel Biodegradable Polymers for Tissue EngineeringCato Laurencin; Fiscal Year: 2004..It is anticipated that at the completion of this project, a viable alternative to existing bone repair materials may be established. ..