bone substitutes

Summary

Summary: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.

Top Publications

  1. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
  2. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
  3. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
  4. ncbi Third-generation biomedical materials
    Larry L Hench
    Department of Materials and the Tissue Engineering Centre, Imperial College of Science, Technology and Medicine, University of London, Prince Consort Road, London SW7 2BP, UK
    Science 295:1014-7. 2002
  5. ncbi A tissue engineering approach to bone repair in large animal models and in clinical practice
    Ranieri Cancedda
    Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genova, Italy
    Biomaterials 28:4240-50. 2007
  6. ncbi The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials
    Marco Esposito
    Oral and Maxillofacial Surgery, Cochrane Oral Health Group, School of Dentistry, The University of Manchester, United Kingdom
    Int J Oral Maxillofac Implants 21:696-710. 2006
  7. ncbi Non-mulberry silk gland fibroin protein 3-D scaffold for enhanced differentiation of human mesenchymal stem cells into osteocytes
    Biman B Mandal
    Department of Biotechnology, Indian Institute of Technology IIT, Kharagpur 721302, West Bengal, India
    Acta Biomater 5:2579-90. 2009
  8. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
  9. pmc Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics
    Florence Barrere
    Biomedical Technological Institute BMTI, University ofTwente, Enschede, The Netherlands
    Int J Nanomedicine 1:317-32. 2006
  10. ncbi Collagen-hydroxyapatite composites for hard tissue repair
    D A Wahl
    Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
    Eur Cell Mater 11:43-56. 2006

Detail Information

Publications310 found, 100 shown here

  1. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
    ....
  2. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
    ..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
  3. ncbi Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
    ..We present here an overview of bone grafts and graft substitutes available for clinical applications...
  4. ncbi Third-generation biomedical materials
    Larry L Hench
    Department of Materials and the Tissue Engineering Centre, Imperial College of Science, Technology and Medicine, University of London, Prince Consort Road, London SW7 2BP, UK
    Science 295:1014-7. 2002
    ....
  5. ncbi A tissue engineering approach to bone repair in large animal models and in clinical practice
    Ranieri Cancedda
    Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genova, Italy
    Biomaterials 28:4240-50. 2007
    ..In particular, the supply of oxygen and nutrients to the cells in the inner part of the implanted scaffolds remains a major concern, requiring additional investigations...
  6. ncbi The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials
    Marco Esposito
    Oral and Maxillofacial Surgery, Cochrane Oral Health Group, School of Dentistry, The University of Manchester, United Kingdom
    Int J Oral Maxillofac Implants 21:696-710. 2006
    ..Trials were divided into 3 categories: (1) major vertical or horizontal bone augmentation (or both); (2) implants placed in extraction sockets; (3) fenestrated implants...
  7. ncbi Non-mulberry silk gland fibroin protein 3-D scaffold for enhanced differentiation of human mesenchymal stem cells into osteocytes
    Biman B Mandal
    Department of Biotechnology, Indian Institute of Technology IIT, Kharagpur 721302, West Bengal, India
    Acta Biomater 5:2579-90. 2009
    ..The results suggest the suitability of non-mulberry silk-fibroin protein 3-D scaffolds as natural biomaterial for potential in vitro bone-tissue engineering applications...
  8. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
    ..MBCP implants with 565 microm pore diameter and 40% macroporosity represented the optimal association for homogeneous and abundant bone ingrowth...
  9. pmc Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics
    Florence Barrere
    Biomedical Technological Institute BMTI, University ofTwente, Enschede, The Netherlands
    Int J Nanomedicine 1:317-32. 2006
    ....
  10. ncbi Collagen-hydroxyapatite composites for hard tissue repair
    D A Wahl
    Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
    Eur Cell Mater 11:43-56. 2006
    ..Solid free form fabrication where a mould can be built up layer by layer, providing shape and internal vascularisation may provide an improved method of creating composite structures...
  11. ncbi Bone substitutes in the Netherlands - a systematic literature review
    Johan van der Stok
    Department of Surgery Traumatology, Erasmus MC, University Medical Centre Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Acta Biomater 7:739-50. 2011
    ..This has resulted in the development of alternative (synthetic) bone substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of ..
  12. ncbi Osteoinduction by biomaterials--physicochemical and structural influences
    Pamela Habibovic
    Department Bilthoven, Institute for Biomedical Technology, University of Twente, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
    J Biomed Mater Res A 77:747-62. 2006
    ....
  13. ncbi Synchrotron X-ray microtomography (on a micron scale) provides three-dimensional imaging representation of bone ingrowth in calcium phosphate biomaterials
    P Weiss
    Laboratoire de Recherche sur les Matériaux d Intérêt Biologique INSERM 99 03, Faculte de Chirurgie Dentaire, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 01, France
    Biomaterials 24:4591-601. 2003
    ..micron scale to compare three-dimensional (3D) bone ingrowth after implantation of various calcium phosphate bone substitutes in a rabbit model...
  14. ncbi Poly (D,L-lactide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation
    Jie Ren
    Institute of Nano and Bio Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, 200092, P R China
    J Mater Sci Mater Med 19:1075-82. 2008
    Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping...
  15. ncbi Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivo
    Frank M Klenke
    Department Clinical Research, Group for Bone Biology and Orthopedic Research, University of Berne, CH 3010 Berne, Switzerland
    J Biomed Mater Res A 85:777-86. 2008
    ..15 (+/-0.06) mm(3)]. Similar results were observed for the BIC. The data demonstrates pore size to be a critical parameter governing the dynamic processes of vascularization and osseointegration of bone substitutes.
  16. ncbi Allograft and alloplastic bone substitutes: a review of science and technology for the craniomaxillofacial surgeon
    Barry L Eppley
    Division of Plastic Surgery, Indiana School of Medicine, Indianapolis, Indiana, USA
    J Craniofac Surg 16:981-9. 2005
    ....
  17. ncbi Orthopaedic applications of bone graft & graft substitutes: a review
    S K Nandi
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India
    Indian J Med Res 132:15-30. 2010
    ..We review the currently available bone graft and graft substitutes for the novel therapeutic approaches in clinical setting of orthopaedic surgery...
  18. ncbi Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits
    Xin Xin Shao
    Department of Orthopaedic Surgery, National University of Singapore, 10 Lower Kent Ridge Road, Singapore 119260, Singapore
    Biomaterials 27:1071-80. 2006
    ....
  19. ncbi Static and dynamic cultivation of bone marrow stromal cells on biphasic calcium phosphate scaffolds derived from an indirect rapid prototyping technique
    M Schumacher
    Friedrich Baur Research Institute for Biomaterials, University of Bayreuth, 95440 Bayreuth, Germany
    J Mater Sci Mater Med 21:3039-48. 2010
    ..Therefore, scaffolds manufactured from BCP ceramic and seeded with BMSCs using a dynamic culture system are the method of choice for bone tissue engineering...
  20. ncbi The compatibility of ceramic bone graft substitutes as allograft extenders for use in impaction grafting of the femur
    A W Blom
    Department of Orthopaedic Surgery, Bristol Royal Infirmary, Bristol, England, UK
    J Bone Joint Surg Br 87:421-5. 2005
    ..There was no statistically significant difference between the four groups after 18 months of unrestricted functional loading for all outcome measures...
  21. ncbi Bone graft substitutes
    Reena A Bhatt
    Department of Plastic Surgery, Warren Alpert Medical School of Brown University, The Miriam and Rhode Island Hospitals, 235 Plain Street, Providence, RI 02903, USA
    Hand Clin 28:457-68. 2012
    ..Considerations in selecting bone grafts and substitutes include characteristic capabilities, availability, patient morbidity, immunogenicity, potential disease transmission, and cost variability...
  22. pmc Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: evaluation in vitro using osteoblast-like cells and in vivo in a bone defect
    Silvia Panseri
    Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy
    PLoS ONE 7:e38710. 2012
    ....
  23. ncbi Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?
    Tara L Aghaloo
    University of California at Los Angeles UCLA School of Dentistry, Los Angeles, California 90049 6603, USA
    Int J Oral Maxillofac Implants 22:49-70. 2007
    ..The aim of this systematic review was to identify the most successful technique(s) to provide the necessary alveolar bone to place a dental implant and support long-term survival...
  24. ncbi Demineralized bone matrix in bone repair: history and use
    ELLIOTT GRUSKIN
    Synthes USA, 1302 Wrights Lane East, West Chester, PA 19380, USA
    Adv Drug Deliv Rev 64:1063-77. 2012
    ....
  25. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008
    ..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone ..
  26. ncbi The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture
    Shinichi Maeno
    Department of Orthopaedic Surgery, Keio University Hospital, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    Biomaterials 26:4847-55. 2005
    ..Considering the viability of embedded cells, culturing scaffolds in media with Ca2+ concentrations around 5mM is useful for both HAp deposition and osteoblast behavior...
  27. ncbi Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
    Shahram Ghanaati
    Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Acta Biomater 6:4476-87. 2010
    ..The data from this study showed that all investigated β-TCP bone substitutes induced the formation of multinucleated giant cells...
  28. ncbi A novel calcium phosphate ceramic-magnetic nanoparticle composite as a potential bone substitute
    Yao Wu
    National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, People s Republic of China
    Biomed Mater 5:15001. 2010
    ..Accordingly, it might be expected that this CaP-MNP composite could become a potential bone substitute or bone tissue engineering scaffold...
  29. ncbi A novel route in bone tissue engineering: magnetic biomimetic scaffolds
    N Bock
    Istituto per lo Studio dei Materiali Nanostrutturati ISMN CNR, Via P Gobetti 101, Bologna 40129, Italy
    Acta Biomater 6:786-96. 2010
    ..Hence, this new type of scaffold is a valuable candidate for tissue engineering applications, featuring a novel magnetic guiding option...
  30. ncbi Tissue engineering of bone: material and matrix considerations
    Yusuf Khan
    University of Virginia School of Medicine, 400 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:36-42. 2008
    ....
  31. ncbi Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation
    V Maquet
    Centre for Education and Research on Macromolecules, University of Liege, Belgium
    Biomaterials 25:4185-94. 2004
    ..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
  32. ncbi 3D microenvironment as essential element for osteoinduction by biomaterials
    Pamela Habibovic
    Institute for Biomedical Technology, Twente University, Department Bilthoven, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
    Biomaterials 26:3565-75. 2005
    ....
  33. ncbi Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate
    Yoshitake Takahashi
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 26:4856-65. 2005
    ..These results suggest that the maintenance of the intrasponge space necessary for the osteoinduction is one factor contributing to the osteoinduction extent of BMP-2-incorporating sponges...
  34. ncbi The in-vitro bioactivity of mesoporous bioactive glasses
    Xiaoxia Yan
    Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China
    Biomaterials 27:3396-403. 2006
    ..According to our results, MBGs calcined at 973K may possess the best in vitro bioactivity. The influences of the composition and calcination temperature upon bioactivity are explained in terms of the unique structures of MBGs...
  35. ncbi Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates
    Anand S Badami
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0211, USA
    Biomaterials 27:596-606. 2006
    ..These studies show that topographical factors designed into biomaterial scaffolds can regulate spreading, orientation, and proliferation of osteoblastic cells...
  36. ncbi Ridge preservation with the use of Bio-Oss collagen: A 6-month study in the dog
    Mauricio G Araújo
    Department of Dentistry, State University of Maringa, Parana, Brazil
    Clin Oral Implants Res 20:433-40. 2009
    ..In previous short-term studies, it was observed that while the placement of biomaterial in alveolar sockets may promote bone formation and ridge preservation, the graft may in fact also delay healing...
  37. ncbi Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop
    Ulrich Kneser
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Erlangen, Germany
    Tissue Eng 12:1721-31. 2006
    ..Our aim was to induce axial vascularization in a processed bovine cancellous bone (PBCB) matrix using an arteriovenous (AV) loop (artery, vein graft, and vein)...
  38. ncbi A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation
    T Livingston Arinzeh
    Osiris Therapeutics, Inc, Baltimore, MD, USA
    Biomaterials 26:3631-8. 2005
    ..In vitro studies also demonstrated that 20/80 HA/TCP stimulated the osteogenic differentiation of hMSCs as determined by the expression of osteocalcin...
  39. ncbi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
    ..Research is on-going for the development of alternative bone substitutes of both biological and synthetic origin...
  40. ncbi Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Foundation, USA
    Biomaterials 26:1337-48. 2005
    ..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
  41. ncbi Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting
    Peter Heinl
    University of Erlangen Nuremberg, Department of Materials Science Institute of Science and Technology of Metals, Martensstrasse 5, 91058 Erlangen, Germany
    Acta Biomater 4:1536-44. 2008
    ..The modified bioactive surface is expected to enhance the fixation of the implant in the surrounding bone as well as to improve its long-term stability...
  42. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  43. ncbi The effect of biomimetic apatite structure on osteoblast viability, proliferation, and gene expression
    Yu Fen Chou
    Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
    Biomaterials 26:285-95. 2005
    ..The results of this study suggest differential cell responses to subtle changes in apatite microenvironment...
  44. ncbi Development of biomimetic nano-hydroxyapatite/poly(hexamethylene adipamide) composites
    Xuejiang Wang
    Institute of Materials Science and Technology, Sichuan University, 610064 Chengdu, China
    Biomaterials 23:4787-91. 2002
    ..Chemical binding between inorganic n-HA and polyamide was investigated and discussed. The mechanical properties of the composites were found to match well with those of natural bone...
  45. ncbi Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model
    Justus P Beier
    Department of Plastic and Hand Surgery, University Hospital of Erlangen, Erlangen, Germany
    J Tissue Eng Regen Med 4:216-23. 2010
    ....
  46. ncbi Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2009, USA
    Biomaterials 25:4749-57. 2004
    ..The results suggest that the newly developed NHAP/polymer composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering...
  47. ncbi Bone graft substitutes: past, present, future
    S N Parikh
    Department of Orthopaedics, Children s Hospital Medical Centre, University of Cincinnati, OH 45229, USA
    J Postgrad Med 48:142-8. 2002
    ..The main purpose of this article is to give the reader an idea about the existing market products and products likely to be available in near future...
  48. ncbi Osteoinduction of porous bioactive titanium metal
    Shunsuke Fujibayashi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 25:443-50. 2004
    ..This finding may elucidate the nature of osteoinduction, and lead to the advent of epochal osteoinductive biomaterials for tissue regeneration...
  49. ncbi Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles
    Damien Le Nihouannen
    INSERM EM9903, Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery of Nantes, Place Alexis Ricordeau, 44042 Nantes, France
    Bone 36:1086-93. 2005
    ..The different hypotheses explaining ectopic bone formation induced by MBCP granules are discussed. Synthetic bone substitutes with osteoinductive properties could be used in bone reconstructive surgery.
  50. ncbi Nanosized and nanocrystalline calcium orthophosphates
    Sergey V Dorozhkin
    Kudrinskaja sq 1 155, Moscow 123242, Russia
    Acta Biomater 6:715-34. 2010
    ..The review also provides possible directions for future research and development...
  51. ncbi In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model
    N Patel
    Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Cambridge, CB2 3QZ, UK
    J Mater Sci Mater Med 16:429-40. 2005
    ....
  52. ncbi Closure of rabbit calvarial critical-sized defects using protective composite allogeneic and alloplastic bone substitutes
    Albert J Haddad
    Orthobiologics Laboratory and Oral and Maxillofacial Surgery, University of Toronto, Toronto, Ontario, Canada
    J Craniofac Surg 17:926-34. 2006
    ..cranial vault defects in thirty New Zealand white rabbits using various allogeneic and alloplastic bone substitutes designed to provide mechanical protection to the brain as well as osteoinductivity...
  53. ncbi Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering
    Jessica M Williams
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
    Biomaterials 26:4817-27. 2005
    ....
  54. ncbi Bone formation and resorption of highly purified beta-tricalcium phosphate in the rat femoral condyle
    Naoki Kondo
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 1, Asahimachi Dori, Niigata 951 8510, Japan
    Biomaterials 26:5600-8. 2005
    ..beta-TCP has a good biocompatibility since both bioresorption and bone formation started at an early stage after implantation...
  55. ncbi Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts
    Yefang Zhou
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 119260, Singapore
    Biomaterials 28:814-24. 2007
    ....
  56. ncbi Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone
    E Garreta
    Barcelona Bioengineering Center, Institut Quimic de Sarria, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain
    Biomol Eng 24:75-80. 2007
    ..We have observed that the mESC can be induced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particles into the nanofiber scaffold...
  57. pmc Single-level cervical radiculopathy: clinical outcome and cost-effectiveness of four techniques of anterior cervical discectomy and fusion and disc arthroplasty
    Arup K Bhadra
    Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP, UK
    Eur Spine J 18:232-7. 2009
    ..Single-level cervical radiculopathy was treated with four different techniques. The clinical outcome and cost-effectiveness were compared in this study...
  58. ncbi A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pig
    Werner Gotz
    Dept of Orthodontics, Oral Biology Laboratory, University of Bonn, Dental Hospital, Bonn, Germany
    Folia Histochem Cytobiol 48:589-96. 2010
    ..The results of this preliminary study indicate that this biomaterial has osteoinductive potential and induces the formation of bone structures, mainly in subcutaneous adipose tissue in the pig...
  59. ncbi Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier
    Philip Kasten
    Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr 200A, 69118 Heidelberg, Germany
    Biomaterials 26:5879-89. 2005
    ..Ectopic bone formation in the novel biomaterial CDHA varied considerably with the cell pool and was at least equal to beta-TCP blocks...
  60. pmc Impaction bone grafting of the acetabulum at hip revision using a mix of bone chips and a biphasic porous ceramic bone graft substitute
    Ashley W Blom
    Department of Academic Orthopaedics, University of Bristol, BIRC Research Labs, Avon Orthopaedic Centre, Bristol
    Acta Orthop 80:150-4. 2009
    ..Previous in vitro and in vivo studies have yielded good results using mixtures of allograft and BoneSave, when compared with allograft alone. This study is the first reported human clinical trial of BoneSave in impaction grafting...
  61. pmc Reduced adhesion of macrophages on anodized titanium with select nanotube surface features
    Amancherla Rajyalakshmi
    Non Ferrous Materials Technology Development Centre, Hyderabad, India
    Int J Nanomedicine 6:1765-71. 2011
    ..This in vitro study thus demonstrated a reduced density of macrophages on anodized Ti, thereby providing further evidence of the greater efficacy of anodized Ti for orthopedic applications...
  62. ncbi Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite
    Michael Thorwarth
    Department of Oral and Maxillofacial Surgery Plastic Surgery, University of Jena, Erlanger Allee 101, D 07747 Jena, Germany
    J Oral Maxillofac Surg 63:1626-33. 2005
    ..The regenerative potentials of the tested materials were compared with each other...
  63. ncbi Histologic analysis of allograft mixed with hydroxyapatite-tricalcium phosphate used in revision femoral impaction bone grafting
    Takaaki Fujishiro
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Orthopedics 31:277. 2008
    ....
  64. ncbi Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using 3D-nano-CT
    Volker Alt
    Department of Trauma Surgery, Justus Liebig University Giessen, Germany
    Acta Biomater 7:3773-9. 2011
    ..8) but not with the dimension of the fracture zone (r=0.3). Nano-CT imaging is feasible for quantitative analysis of angiogenesis during bony integration of biomaterials and a promising tool in this context for the future...
  65. ncbi In vivo performance of bilayer hydroxyapatite scaffolds for bone tissue regeneration in the rabbit radius
    Teja Guda
    Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Fort Sam Houston, TX 78234, USA
    J Mater Sci Mater Med 22:647-56. 2011
    ....
  66. ncbi Impaction grafting of the acetabulum with a mixture of frozen, ground irradiated bone graft and porous synthetic bone substitute (Apapore 60)
    I McNamara
    Department of Orthopaedics, West Suffolk Hospital, Bury St Edmunds, UK
    J Bone Joint Surg Br 92:617-23. 2010
    ..Longer follow-up will be required to establish whether this technique is as effective as using fresh-frozen allograft...
  67. ncbi Characterization of a bovine collagen-hydroxyapatite composite scaffold for bone tissue engineering
    C V M Rodrigues
    Programa de Engenharia Metalurgica e de Materiais, COPPE, UFRJ, 21945 970 Rio de Janeiro, RJ, Brazil
    Biomaterials 24:4987-97. 2003
    ..The biocomposite studied has several characteristics considered as ideal for its use as a scaffold for osteoconduction and osteoinduction...
  68. ncbi Osteotomy of distal radius fracture malunion using a fast remodeling bone substitute consisting of calcium sulphate and calcium phosphate
    Antonio Abramo
    Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden
    J Biomed Mater Res B Appl Biomater 92:281-6. 2010
    ..A more rigid fixation may improve the radiographic outcome with this kind of bone substitute...
  69. ncbi Cost comparison of femoral head banking versus bone substitutes
    Hon Bong Leung
    Department of Orthopaedics and Traumatology, Queen Mary Hospital, Pokfulam, Hong Kong
    J Orthop Surg (Hong Kong) 18:50-4. 2010
    To compare the costs of femoral head banking versus bone substitutes.
  70. ncbi Bioresorbability, porosity and mechanical strength of bone substitutes: what is optimal for bone regeneration?
    Gerjon Hannink
    Orthopaedic Research Laboratory, Department of Orthopaedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Injury 42:S22-5. 2011
    ..It is known that intrinsic material properties of CaP bone substitutes have a profound effect on their mechanical and biological behaviour and associated biodegradation...
  71. ncbi Inorganic materials for bone repair or replacement applications
    Audrey Hertz
    University of Kent, Department of Biosciences, Canterbury, CT2 7NJ, UK
    Nanomedicine (Lond) 2:899-918. 2007
    ....
  72. ncbi Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction
    Stephan T Becker
    Department of Oral and Maxillofacial Surgery, Christian Albrechts University Kiel, Germany
    Oral Oncol 45:e181-8. 2009
    ..Further studies should explore if the stability of the individually designed blocks is sufficient to cultivate larger replacements without an external matrix for support...
  73. ncbi The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate cer
    Shahram Ghanaati
    Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Biomed Mater 7:015005. 2012
    ..Both of these factors are necessary for successful bone tissue regeneration...
  74. ncbi Effect of beta-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humans
    Christine Knabe
    Department of Experimental Dentistry, Campus Benjamin Franklin, Charite University Medical Center Berlin, Abmannshauser Strasse 4 6, D 14197 Berlin, Germany
    Biomaterials 29:2249-58. 2008
    ..Consequently, a greater porosity appears to be advantageous for enhancing bone formation and particle degradation...
  75. ncbi Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical properties
    M Schumacher
    Friedrich Baur Research Institute for Biomaterials, University of Bayreuth, 95440, Bayreuth, Germany
    J Mater Sci Mater Med 21:3119-27. 2010
    ..This strength level is within and above the range of human cancellous bone. Therefore, this technique is well suited to manufacture scaffolds for bone tissue engineering...
  76. ncbi Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering
    Moncy V Jose
    Department of Materials Science and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Biomater 5:305-15. 2009
    ..The mechanical behavior showed a sinusoidal trend with a slight decrease in modulus by week 1 due to the plasticizing effect of the medium followed by an increase due to shrinkage, and a subsequent drop by week 6 due to degradation...
  77. ncbi The efficacy of Biobon and Ostim within metaphyseal defects using the Göttinger Minipig
    Christian K G Spies
    Klinik für Orthopädie und Unfallchirurgie, Universitatsklinikum Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Arch Orthop Trauma Surg 129:979-88. 2009
    To compare bio, osteocompatibility, rate of resorption and remodeling dynamics of two clinically used bone substitutes.
  78. ncbi Nano-hydroxyapatite/poly(L-lactic acid) composite synthesized by a modified in situ precipitation: preparation and properties
    C Y Zhang
    Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, People s Republic of China
    J Mater Sci Mater Med 21:3077-83. 2010
    ..This supports the potential of these composites for applications in bone tissue engineering and load bearing bone defects repair...
  79. ncbi Bone graft substitutes: What are the options?
    Haralambos Dinopoulos
    Academic Department of Trauma and Orthopaedic Surgery, Clarendon Wing, Floor A, Great George Street, Leeds General Infirmary, LS1 3EX Leeds, UK
    Surgeon 10:230-9. 2012
    ..In this review, we summarise the available bone grafting materials, focussing mainly on the various bone substitutes and their characteristics, in an effort to specify the indications for their use.
  80. ncbi Selective bone cell adhesion on formulations containing carbon nanofibers
    Rachel L Price
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
    Biomaterials 24:1877-87. 2003
    ..Moreover, greater weight percentages of high surface energy carbon nanofibers in the PCU/CNF composite increased osteoblast adhesion while at the same time decreased fibroblast adhesion...
  81. ncbi The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue
    Takatoshi Okuda
    Department of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biomaterials 28:2612-21. 2007
    ..These results showed that the microstructure of beta-TCP affects the activity of bone cells and subsequent bone replacement...
  82. ncbi The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair
    Yang Cui
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, People s Republic of China
    Acta Biomater 5:2680-92. 2009
    ..All the data extrapolated that the composite with 10 and 20wt.% op-HA exhibited better comprehensive properties and were the optimal composites for bone repairing...
  83. ncbi Augmentation of bone defect healing using a new biocomposite scaffold: an in vivo study in sheep
    U van der Pol
    AO Research Institute, Clavadelerstrasse 8, Davos, Switzerland
    Acta Biomater 6:3755-62. 2010
    ....
  84. ncbi The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting
    J J Chris Arts
    Orthopaedic Research Laboratory, Department Orthopaedics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 27:1110-8. 2006
    ..In conclusion, Ostim HA-paste could be a valuable addition when TCP-HA ceramic granules are being used for acetabular bone impaction grafting procedures...
  85. ncbi Resorbability of bone substitute biomaterials by human osteoclasts
    Arndt F Schilling
    Department of Trauma, Hand, and Reconstructive Surgery, Center for Biomechanics, Hamburg University School of Medicine, Martinistrasse 52, Hamburg 20246, Germany
    Biomaterials 25:3963-72. 2004
    ..So far the only way to test this biological property of bone substitutes are animal experiments with all their limitations like ethics, costs and limited transferability to man...
  86. ncbi Immunoexpression of Cbfa-1/Runx2 and VEGF in sinus lift procedures using bone substitutes in rabbits
    Leandro Soeiro de Souza Nunes
    Department of Health Sciences, Discipline of Oral and Maxillofacial Surgery, School of Dentistry, Sagrado Coracao University, USC, Bauru, Sao Paulo, SP, Brazil
    Clin Oral Implants Res 21:584-90. 2010
    ..To analyze and compare the expression of core binding factor-1 (Cbfa-1)/Runx2 and vascular endothelium growth factor (VEGF) in sinus lift procedures using bovine hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP)...
  87. ncbi Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment
    Joerg Wiltfang
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 15:187-93. 2004
    ..An animal study was carried out to investigate the influence of platelet-rich plasma (PRP) on the regeneration of bony defects...
  88. ncbi Formation of osteoclast-like cells on HA and TCP ceramics
    R Detsch
    BioCer Entwicklungs GmbH, 95447 Bayreuth, Germany
    Acta Biomater 4:139-48. 2008
    ..On the other hand, highly soluble calcium phosphate ceramics like TCP seem to be inappropriate for osteoclast resorption because they produce a high calcium concentration in the osteoclast interface and in the environment...
  89. ncbi Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration
    Fangfang Sun
    Department of Nanomedical Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Miryang 627 706, Republic of Korea
    Acta Biomater 7:3813-28. 2011
    ..Finally, we provide a summary and our own perspectives on this active area of research...
  90. ncbi Regenerative treatment of peri-implantitis using bone substitutes and membrane: a systematic review
    Philipp Sahrmann
    Clinic for Preventive Dentistry, Periodontology and Cariology, Center for Dental and Oral Medicine, University of Zurich, Plattenstrasse 11, Zurich, Switzerland
    Clin Implant Dent Relat Res 13:46-57. 2011
    ..This systematic review aimed to assess the available literature for regenerative treatment of peri-implantitis using bone graft substitutes and membranes...
  91. ncbi Biologically inspired rosette nanotubes and nanocrystalline hydroxyapatite hydrogel nanocomposites as improved bone substitutes
    Lijie Zhang
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Nanotechnology 20:175101. 2009
    ..In summary, the presently observed excellent properties of the biomimetic nanocrystalline HA/HRN hydrogel composites make them promising candidates for further study for bone tissue engineering applications...
  92. ncbi Autogenous bone grafts and bone substitutes--tools and techniques: I. A 20,000-case experience in maxillofacial and craniofacial surgery
    P Tessier
    Miami Children s Hospital, Miami, FL 33155, USA
    Plast Reconstr Surg 116:6S-24S; discussion 92S-94S. 2005
    Alloplastic bone substitutes can be used to alter facial contour. In contrast, autogenous bone grafts have a successful 80-year history of restoring facial contour as well as the basic functional support of the craniofacial skeleton...
  93. doi Bone substitutes and growth factors as an alternative/complement to autogenous bone for grafting in implant dentistry
    Mats Hallman
    Periodontol 2000 47:172-92. 2008
  94. ncbi Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs
    Simon Storgård Jensen
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Bern, Switzerland
    Clin Oral Implants Res 17:237-43. 2006
    The purpose was to qualitatively and quantitatively compare the bone formation and graft resorption of two different bone substitutes used in both orthopedic and oral surgery, with autogenous bone as a positive control.
  95. ncbi A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization
    A M Ambrosio
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 58:295-301. 2001
    ..Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications...
  96. ncbi Comparative performance of three ceramic bone graft substitutes
    Karin A Hing
    IRC in Biomedical Materials, Queen Mary University of London, London, United Kingdom
    Spine J 7:475-90. 2007
    ..There is, however, a lack of comparative performance data regarding the relative efficacy of these materials when placed in an osseous defect site...
  97. ncbi Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model
    William R Walsh
    Surgical and Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, L1 Clinical Sciences Building, Sydney 2031, Australia
    Biomaterials 29:266-71. 2008
    ..Vitoss resorbed faster than the other materials and is likely to differences in particle geometry, pore structure and interconnectivity...
  98. pmc Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes
    Youzhuan Xie
    Department of Orthopaedics, Ninth People s Hospital, Shanghai Second Medical University, 200011, Shanghai, China
    Eur Spine J 15:1196-203. 2006
    Few histological studies on bone substitutes in human cervical spine are available and the biological processes of bone substitutes are not well documented...
  99. ncbi Comparative in vivo study of six hydroxyapatite-based bone graft substitutes
    Pamela Habibovic
    University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
    J Orthop Res 26:1363-70. 2008
    ....
  100. ncbi Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis
    William G De Long
    Department of Orthopaedic Surgery, Temple University, One Greentree Centre, Suite 104, Marlton, NJ 08053, USA
    J Bone Joint Surg Am 89:649-58. 2007
  101. ncbi Nanostructured biomaterials for tissue engineering bone
    Thomas J Webster
    Division of Engineering and Orthopaedics, Brown University, Providence, RI 02912, USA
    Adv Biochem Eng Biotechnol 103:275-308. 2007
    ..Such advances were previously unimaginable with conventional materials possessing large micron-sized particulates...

Research Grants63

  1. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
    ..these conditions, as well as improving fracture healing and distraction osteogenesis outcomes, developing bone substitutes for tissue engineering, and improving implant designs...
  2. Studies of Chondroyte Maturation
    Cristina C Teixeira; Fiscal Year: 2010
    ....
  3. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag
    HANNE GRON; Fiscal Year: 2010
    ..The use of Affinergy's proprietary peptides therefore provides effective leverage toward the near doubling of the orthobiologics market. ..
  4. Functional Fluid Flow Regulated Bone Regeneration
    Yi Xian Qin; Fiscal Year: 2013
    ..Tissue engineering approaches show promise as bone substitutes, and have been particularly successful in vitro in a bioreactor environment...
  5. Enhanced coupling of bone regenerative peptides to hydroxyapatite-containing biom
    Bonnie K Culpepper; Fiscal Year: 2012
    ..The proposed research will not only facilitate the development of effective bone substitutes but will also have broad impact, given that the E7 domain is expected to increase anchoring of a wide variety ..
  6. Engineering of Vascularized Bone
    Jeremy J Mao; Fiscal Year: 2012
    ..Current bone substitutes such as hydroxyapatite and grafts are below the surgeon's expectations...
  7. Bone Tissue Engineerig: Effect of Dynamic Perfusion
    Aaron Goldstein; Fiscal Year: 2009
    ..defects, but limited tissue availability and concerns of donor-site complications drive a growing demand for bone substitutes for reconstructive procedures...
  8. Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental Applications
    HANNE GRON; Fiscal Year: 2007
    ..In this project, we are attempting to improve synthetic bone substitutes with Affinergy's linker peptides...
  9. MECHANICALLY GUIDED TISSUE REGENERATION
    Steven Goldstein; Fiscal Year: 2002
    ..and local delivery of biologic factors in stimulating the repair and incorporation of tissue engineered bone substitutes. The models in both a cranial-facial and long bone site utilize specifically designed external fixators which ..
  10. REGULATED OSTEOINDUCTIVE PLASMID GENE TRANSFER VIA GENE
    KEVIN RICE; Fiscal Year: 2002
    ..While likely beyond the scope of the present application, a long term goal will be to measure the efficacy of rationally pre-designed GAM constructs in vivo using established bone defect animal models. ..
  11. OSTEOCLAST REGULATION & OSSEOINTEGRATION OF BIOIMPLANTS
    Peter Hauschka; Fiscal Year: 2002
    ..Rigid, mineralized bone substitutes are clinically important to avoid patient morbidity in craniofacial and spinal surgery...
  12. Bioengineering Annulus Fibrosus using Silk Scaffold
    Rita Kandel; Fiscal Year: 2006
    ..The viability and mechanical properties of the tissue will be evaluated. ..
  13. TANTALUM FOAMS FOR CANCELLOUS BONE IMPLANTS
    Richard Kaplan; Fiscal Year: 1992
    ....
  14. Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental Applications
    HANNE GRON; Fiscal Year: 2009
    ..In this project, we are attempting to improve synthetic bone substitutes with the Affinergy linker peptides...
  15. Intl Symposium - Biphasic Calcium Phosphate Biomaterials
    Racquel LeGeros; Fiscal Year: 2001
    ....
  16. COMPOSITE MATERIALS FOR HARD TISSUE REPLACEMENT
    SILVIA LUEBBEN; Fiscal Year: 2000
    ..During the last few years much research has been devoted to the development of bone substitutes that eventually degrade to allow re-growth of the natural bone...
  17. BIOMATERIAL APPLICATIONS OF COLLAGEN SPONGE
    Milos Chvapil; Fiscal Year: 1980
    ..In three models of bone defect (humerus in rabbits, spine fusion in dogs and mastoid cavity obliteration in guinea pigs) CS promoted fibrotic replacement of the tissue defect. ..
  18. In vivo utilization of Runx2 isoforms during skeletal development
    Julie Liu; Fiscal Year: 2007
    ..promoters and thus drive osteoblast growth and differentiation and 2) to employ this knowledge to engineer bone substitutes that promote faster healing by mimicking the natural processes of the body...
  19. Biodegradable Scaffolds for Periodontal Void-Filling
    DEBRA TRANTOLO; Fiscal Year: 2001
    ..2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in the ever-growing market. ..
  20. Biodegradable Bone Graft Extender
    DEBRA TRANTOLO; Fiscal Year: 2001
    ..If autogenous grafts could be easily extended via a resorbable osteoconductive material, market acceptance would follow. ..
  21. Biodegradable Bone Graft Extender
    David Hile; Fiscal Year: 2004
    ..abstract_text> ..
  22. NANO-HYDROXYAPATITE IN BIOPOLYMERIC SCAFFOLDS FOR BONE
    DEBRA TRANTOLO; Fiscal Year: 2002
    ..There are over 450,000 bone graft procedures annually in the U.S. (2.2 million worldwide) with a market potential of $400 to $600 million. New tissue engineered bone replacement materials would find a niche in this ever growing market. ..
  23. REGENERATION WITH PDGF TREATED OSTEOCONDUCTIVE MATERIALS
    Samuel Lynch; Fiscal Year: 2001
    ..Certain Bone substitutes have also been shown to enhance periodontal regeneration in both animal models and in humans...
  24. Conducting Biomaterials for Nerve Regeneration
    SILVIA LUEBBEN; Fiscal Year: 2001
    ..TDA's soluble conducting polymer could also have non-biomedical applications as an antistatic material, for EMI-shielding, in electronic components and radar-absorbing materials. ..
  25. A Novel Osteoinductive Molecule in Bone Regeneration
    Chia Soo; Fiscal Year: 2005
    ..Our long term goal is to develop an effective autograft bone substitute. ..
  26. Bioactive Resorbable Putty Graft and Formable Plates
    Maurice Valen; Fiscal Year: 2001
    ..We feel the development of these new bone substitutes and regenerative materials will result in numerous commercial products that are better than any currently ..
  27. THREE DIMENSIONAL SCAFFOLDS FOR BONE TISSUE ENGINEERING
    JOSEPH STANCO; Fiscal Year: 2000
    ..S. to promote growth of bone with bone grafts or bone substitutes. Currently available bone substitutes are far from ideal and have many associated problems...
  28. NANO-HYDROXYAPATITE SCAFFOLDS TO FILL PERIODONTAL VOIDS
    DEBRA TRANTOLO; Fiscal Year: 2001
    ..2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in this ever-growing market. ..
  29. Composite HA-Alumina Implants with Biomimetic Properties
    EUGENIE EMORY; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATIONS: Bone substitutes are necessary to help repair or replace damaged, diseased, or missing bone tissue...
  30. FABRICATION OF ORAL & MAXILLOFACIAL BIOCERAMIC STUCTURES
    EUGENIE EMORY; Fiscal Year: 2001
    ..proposed commercial application: not available ..
  31. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  32. MINERALIZATION OF POLYMERIZED PHOSPHOLIPID ASSEMBLIES
    PHILLIP MESSERSMITH; Fiscal Year: 2001
    ..medical and dental applications of this technology include th remineralization of incipient caries, treatment of hypersensitive dentin, and as a bone substitute material. ..
  33. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  34. A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery
    STEPHEN HARREL; Fiscal Year: 2007
    ..The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS. [unreadable] [unreadable] [unreadable]..
  35. The Role of VDR in PTH and Vitamin D3(D3) Synergy
    Tara Aghaloo; Fiscal Year: 2008
    ..These studies will help understand the mechanisms of PTH and D3 synergy through VDR and their effects on osteoblastic differentiation and function. [unreadable] [unreadable] [unreadable]..
  36. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  37. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
    ..4. Image the three-dimensional damage developed in cortical bone specimens following low cycle fatigue in four point bending. Differences in damage patterns due to pure bending and combined bending and shear loading will be identified. ..
  38. Novel Biodegradable Materials for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2008
    ..Specific Aim 3: To perform biological evaluation of novel blends of polyphosphazenes with PLAGA using in vivo animal models. ..
  39. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  40. Rabbit Model for In Vivo Monitoring of Bone Structure
    Michael Voor; Fiscal Year: 2003
    ..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
  41. THE UBIQUITIN-PROTEOSOME PATHWAY AND BMP-2 EXPRESSION
    Gregory Mundy; Fiscal Year: 2008
    ..abstract_text> ..
  42. Devices for Treating Inflammatory Bone Loss in an Oral Environment
    David A Puleo; Fiscal Year: 2010
    ..This project will develop multifunctional, unitary, controlled release devices that halt the detrimental processes and stimulate localized tissue repair in sites compromised by bacteria. ..
  43. Novel DNA Delivery via Surface Bound Calcium Phosphates
    Jian Tan; Fiscal Year: 2008
    ..The technology developed in this proposal will have important impact on basic research, biotech industry and gene therapy based medicine. [unreadable] [unreadable] [unreadable]..
  44. 2005 Biomaterials Gordon Conference
    KEVIN HEALY; Fiscal Year: 2005
    ..A number of leading scientists and engineers from companies working in the biomaterials and tissue engineering area will also be recruited to participate. ..
  45. Gli Control of PTH-rP and Osteolysis in Breast Cancer
    Gregory Mundy; Fiscal Year: 2009
    ..We propose therefore that the Gli family of transcriptional regulators represents an important molecular pathway that regulates PTH-rP expression in breast cancer cells, and subsequent breast cancer-mediated osteolysis. ..
  46. Bisphosphonates and Oral Complications of Cancer Chemotherapy: A Pilot Study
    Regina Landesberg; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. BIOMIMETIC HYDROGELS FOR BONE REGENERATION
    KEVIN HEALY; Fiscal Year: 2004
    ....
  48. Revision THA Impaction Grafts:Effects of Bone Fusion
    Anneliese Heiner; Fiscal Year: 2003
    ..Successful conclusion of the proposed research will provide biomechanical data that will assist in the optimization of the impaction grafting process, thus improving the clinical success rate of this evolving procedure. ..
  49. Fatigue Crack Morphology in Cemented Hips
    Amos Race; Fiscal Year: 2002
    ....
  50. Gene Therapy for Musculoskeletal Repair
    Cato Laurencin; Fiscal Year: 2004
    ..abstract_text> ..
  51. Student Travel Support for Regenerate 2005
    Robert Guldberg; Fiscal Year: 2005
    ..The second forum will be a Stem Cell Workshop focused on advances in stem cell research. ..
  52. PATIENT ORIENTED RESEARCH--ORAL AND MAXILLOFACIAL SURGER
    THOMAS DODSON; Fiscal Year: 2004
    ..This award leverages the PI's skills and talents by providing protected time to mentor additional trainees and to conduct high quality patient-oriented research. ..
  53. Maturational changes in superficial zone chondrocytes
    Chisa Hidaka; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Effect of Femoral Stem Design om Cement Mantle Failure
    Amos Race; Fiscal Year: 2006
    ..Should these aims be met, the proposed model will be of great use in pre-clinical testing of novel cemented stem designs. ..
  55. Nanopatterned Surfaces to Control Cell Fate
    KEVIN HEALY; Fiscal Year: 2006
    ..abstract_text> ..
  56. IVth Intl Conference on Cancer-Induced Bone Diseases
    Gregory Mundy; Fiscal Year: 2004
    ..Attention will also be given to current diagnostic methods for patients with these skeletal complications of malignancy. ..
  57. Effects of the Mevalonate Pathway on Bone Formation
    Gregory Mundy; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Prospective evaluation of immediate temporized implants
    Michael Block; Fiscal Year: 2007
    ..Standardized hard and soft tissue data will be collected preextraction as baseline, and then prospectively for at least two years in this trial, to compare and contrast the methods. ..
  59. Vascularization and Bone Repair
    Robert Guldberg; Fiscal Year: 2007
    ..Furthermore, the developed methodologies will have broad applicability to other research areas, including for example studies on fracture healing, skeletal development, vascular injury, and tumorigenesis. ..
  60. Polymer/Ceramic Composites for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2009
    ..Specific Aim 3: Evaluation of the biological performance of novel 3-D composite matrices using in vivo techniques. ..
  61. Novel Biodegradable Polymers for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2004
    ..It is anticipated that at the completion of this project, a viable alternative to existing bone repair materials may be established. ..