biocompatible coated materials

Summary

Summary: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.

Top Publications

  1. ncbi Anode glow discharge plasma treatment enhances calcium phosphate adsorption onto titanium plates
    Y Shibata
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Dent Res 81:841-4. 2002
  2. ncbi Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth-First In Man) Registry
    Jiro Aoki
    Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 45:1574-9. 2005
  3. ncbi Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly(L-lysine)-grafted-poly(ethylene glycol) copolymers
    L G Harris
    AO Research Institute, Interface Biology, Clavadelerstrasse, CH7270 Davos Platz, Switzerland
    Biomaterials 25:4135-48. 2004
  4. ncbi Electronic manipulation of DNA, proteins, and nanoparticles for potential circuit assembly
    Lifeng Zheng
    Electrical Engineering and Computer Science, University of California, Irvine, CA 92697 2625, USA
    Biosens Bioelectron 20:606-19. 2004
  5. ncbi Nano-structured polymers enhance bladder smooth muscle cell function
    Anil Thapa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
    Biomaterials 24:2915-26. 2003
  6. ncbi Mechanism(s) of increased vascular cell adhesion on nanostructured poly(lactic-co-glycolic acid) films
    Derick C Miller
    Weldon School of Biomedical Engineering, Purdue University, 500 Central Drive, West Lafayette, IN 47907 2022, USA
    J Biomed Mater Res A 73:476-84. 2005
  7. ncbi Study of antirestenosis with the BiodivYsio dexamethasone-eluting stent (STRIDE): a first-in-human multicenter pilot trial
    Xiaoshun Liu
    Department of Cardiology, University Hospitals Leuven, Leuven, Belgium
    Catheter Cardiovasc Interv 60:172-8; discussion 179. 2003
  8. pmc Deposition of silver nanoparticles on titanium surface for antibacterial effect
    Liao Juan
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China
    Int J Nanomedicine 5:261-7. 2010
  9. ncbi Restenosis following implantation of bare metal coronary stents: pathophysiology and pathways involved in the vascular response to injury
    Neal A Scott
    Camino Cardiovascular Associates, 525 South Drive, Suite 107, Mountain View, CA 94040, USA
    Adv Drug Deliv Rev 58:358-76. 2006
  10. ncbi Biomimetic apatite formation on chemically treated titanium
    Lenka Jonásová
    Department of Materials Science III, University of Erlangen Nuremberg, Martensstrasse 5, Erlangen 91058, Germany
    Biomaterials 25:1187-94. 2004

Detail Information

Publications237 found, 100 shown here

  1. ncbi Anode glow discharge plasma treatment enhances calcium phosphate adsorption onto titanium plates
    Y Shibata
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Dent Res 81:841-4. 2002
    ..In addition, calcium phosphate was not nucleated on the specimen with GDP-. We conclude that GDP+ is more suitable for biomineralization on titanium...
  2. ncbi Endothelial progenitor cell capture by stents coated with antibody against CD34: the HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth-First In Man) Registry
    Jiro Aoki
    Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 45:1574-9. 2005
    ..This study was designed to evaluate whether rapid endothelialization of stainless steel stents with a functional endothelium prevents stent thrombosis and reduces the restenotic process...
  3. ncbi Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly(L-lysine)-grafted-poly(ethylene glycol) copolymers
    L G Harris
    AO Research Institute, Interface Biology, Clavadelerstrasse, CH7270 Davos Platz, Switzerland
    Biomaterials 25:4135-48. 2004
    ..aureus adhesion, resulting in a selective biointeraction pattern that may be useful for applications in the area of osteosynthesis, orthopaedic and dental implantology...
  4. ncbi Electronic manipulation of DNA, proteins, and nanoparticles for potential circuit assembly
    Lifeng Zheng
    Electrical Engineering and Computer Science, University of California, Irvine, CA 92697 2625, USA
    Biosens Bioelectron 20:606-19. 2004
    ..The technique of simultaneously measuring resistance while using dielectrophoresis to trap nanoscale objects should find broad applicability...
  5. ncbi Nano-structured polymers enhance bladder smooth muscle cell function
    Anil Thapa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
    Biomaterials 24:2915-26. 2003
    ..This claim is supported by the fact that cell number was enhanced on nano-structured compared to conventional PLGA and PU once chemistry changes were eliminated using casting techniques...
  6. ncbi Mechanism(s) of increased vascular cell adhesion on nanostructured poly(lactic-co-glycolic acid) films
    Derick C Miller
    Weldon School of Biomedical Engineering, Purdue University, 500 Central Drive, West Lafayette, IN 47907 2022, USA
    J Biomed Mater Res A 73:476-84. 2005
    ..In this manner, this study continues to provide evidence for the promise of nanostructured PLGA in vascular tissue engineering applications...
  7. ncbi Study of antirestenosis with the BiodivYsio dexamethasone-eluting stent (STRIDE): a first-in-human multicenter pilot trial
    Xiaoshun Liu
    Department of Cardiology, University Hospitals Leuven, Leuven, Belgium
    Catheter Cardiovasc Interv 60:172-8; discussion 179. 2003
    ..0.60 +/- 0.55 mm, P < 0.07, and 26.86 +/- 14 vs. 38.40 +/- 16%, P < 0.02). This study demonstrated the feasibility and safety of the implantation of a dexamethasone-eluting stent and its effect on in-stent neointimal hyperplasia...
  8. pmc Deposition of silver nanoparticles on titanium surface for antibacterial effect
    Liao Juan
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China
    Int J Nanomedicine 5:261-7. 2010
    ..These data suggest that silver nanoparticle-modified titanium is a promising material with an antibacterial property that may be used as an implantable biomaterial...
  9. ncbi Restenosis following implantation of bare metal coronary stents: pathophysiology and pathways involved in the vascular response to injury
    Neal A Scott
    Camino Cardiovascular Associates, 525 South Drive, Suite 107, Mountain View, CA 94040, USA
    Adv Drug Deliv Rev 58:358-76. 2006
    ..Although preliminary data suggest that the use of drug-eluting stents may be effective, only intracoronary radiation has shown consistent efficacy in randomized trials...
  10. ncbi Biomimetic apatite formation on chemically treated titanium
    Lenka Jonásová
    Department of Materials Science III, University of Erlangen Nuremberg, Martensstrasse 5, Erlangen 91058, Germany
    Biomaterials 25:1187-94. 2004
    ..The treatment of titanium by acid etching in HCl and subsequently in NaOH is a suitable method for providing the metal implant with bone-bonding ability...
  11. ncbi Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study
    J E Sousa
    Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil
    Circulation 103:192-5. 2001
    ..Restenosis remains an important limitation of interventional cardiology. Therefore, we aimed to determine the safety and efficacy of sirolimus (a cell-cycle inhibitor)-coated BX Velocity stents...
  12. ncbi Preparation and characterization of rapamycin-loaded PLGA coating stent
    C J Pan
    Key Lab for Advanced Technologies of Materials of Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China
    J Mater Sci Mater Med 18:2193-8. 2007
    ..Take into these results account, this novel rapamycin-eluting may be a good candidate to resolve in-stent restenosis...
  13. ncbi Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin
    T J Webster
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA
    Tissue Eng 7:291-301. 2001
    ..These events, namely, enhanced vitronectin adsorption, comformation, and bioactivity, may explain the increased osteoblast adhesion on nanophase alumina...
  14. ncbi Vascular response to sirolimus-eluting stents delivered with a nonaggressive implantation technique: comparison of intravascular ultrasound results from the multicenter, randomized E-SIRIUS, and SIRIUS trials
    Rainer Hoffmann
    Medical Clinic I, University Hospital Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 66:499-506. 2005
    ....
  15. ncbi Effect of sirolimus-eluting stent in diabetic patients with small coronary arteries (a SES-SMART substudy)
    Paolo Ortolani
    Institute of Cardiology, Policlinico S Orsola, University of Bologna, Bologna, Italy
    Am J Cardiol 96:1393-8. 2005
    ..In conclusion, in diabetics with small coronary arteries, SES implantation significantly reduces the incidence of the 8-month angiographic restenosis rate compared with BMSs...
  16. ncbi Early failure of precoated femoral components in primary total hip arthroplasty
    Alvin Ong
    Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Bone Joint Surg Am 84:786-92. 2002
    ..Reports differ as to whether this step has increased or decreased the rate of failure. This study was designed to evaluate this issue...
  17. ncbi Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies
    Raul Moreno
    Division of Interventional Cardiology, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain
    J Am Coll Cardiol 45:954-9. 2005
    ..We compared the risk of stent thrombosis (ST) after drug-eluting stents (DES) versus bare-metal stents (BMS), and tested the hypothesis that the risk of DES thrombosis is related to stent length...
  18. ncbi Paclitaxel coating reduces in-stent intimal hyperplasia in human coronary arteries: a serial volumetric intravascular ultrasound analysis from the Asian Paclitaxel-Eluting Stent Clinical Trial (ASPECT)
    Myeong Ki Hong
    Department of Medicine, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
    Circulation 107:517-20. 2003
    ..The aim of this study was to use serial volumetric intravascular ultrasound (IVUS) to evaluate the effect of a paclitaxel coating on in-stent intimal hyperplasia (IH)...
  19. ncbi Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes
    Seung Han Oh
    Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, Bldg EBU 2, RM, La Jolla, CA 92093, USA
    Biomaterials 26:4938-43. 2005
    ..Such TiO2 nanotube arrays and associated nanostructures can be useful as a well-adhered bioactive surface layer on Ti implant metals for orthopaedic and dental implants, as well as for photocatalysts and other sensor applications...
  20. ncbi Helical rosette nanotubes: a biomimetic coating for orthopedics?
    Ai Lin Chun
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 2022, USA
    Biomaterials 26:7304-9. 2005
    ....
  21. ncbi Role of stent design and coatings on restenosis and thrombosis
    Hidehiko Hara
    Minnesota Cardiovascular Research Institute, Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, 920 East 28th Street Suite 620, Minneapolis, MN, 55407, USA
    Adv Drug Deliv Rev 58:377-86. 2006
    ..This chapter describes stents which have subtle influences of modular design, metal coverage, strut thickness, strut shape, surface smoothness, and coating materials like an alloy composition...
  22. ncbi Covered versus uncovered wallstent for malignant extrahepatic biliary obstruction: a cohort comparative analysis
    Do Hyun Park
    Department of Internal Medicine, Soon Chun Hyang University Cheonan Hospital, Cheonan, Korea
    Clin Gastroenterol Hepatol 4:790-6. 2006
    ....
  23. ncbi Enhanced osteoblast adhesion on hydrothermally treated hydroxyapatite/titania/poly(lactide-co-glycolide) sol-gel titanium coatings
    Michiko Sato
    School of Materials Engineering, Purdue University, West Lafayette, IN 47907, USA
    Biomaterials 26:1349-57. 2005
    ....
  24. pmc Increased osteoblast cell density on nanostructured PLGA-coated nanostructured titanium for orthopedic applications
    Lester J Smith
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA
    Int J Nanomedicine 2:493-9. 2007
    ..This straight forward application of nano-topography on current bone implant materials represents a new direction in the design of enhanced biomaterials for the orthopedic industry...
  25. ncbi Peptide-immobilized nanoporous alumina membranes for enhanced osteoblast adhesion
    Erin E Leary Swan
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Biomaterials 26:1969-76. 2005
    ..Cell secreted matrix was absent on unmodified membranes for the same duration. Vitronectin-adsorbed surfaces did not show significant improvement in adhesion over unmodified membranes...
  26. ncbi Enhanced fibronectin adsorption on carbon nanotube/poly(carbonate) urethane: independent role of surface nano-roughness and associated surface energy
    Dongwoo Khang
    Division of Engineering, Brown University, 184 Hope Street, Providence, RI 02912, USA
    Biomaterials 28:4756-68. 2007
    ....
  27. ncbi Short term in vivo biocompatibility testing of biodegradable poly(D,L-lactide)--growth factor coating for orthopaedic implants
    Britt Wildemann
    Center for Musculoskeletal Surgery, Charite, University Medicine, Augustenburger Platz 1, Berlin D 13353, Germany
    Biomaterials 26:4035-40. 2005
    ..In conclusion, no indication of a foreign body reaction due to the use of the polylactide or the growth factors was found indicating a good short-term biocompatibility of this bioactive coating...
  28. ncbi Drug-eluting bioresorbable stents for various applications
    Meital Zilberman
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Annu Rev Biomed Eng 8:153-80. 2006
    ..Because a lot of research in this field has been done by us, examples for these functions are described based mainly on developments in our laboratories...
  29. ncbi Hydroxyapatite-coated tapered cementless femoral components in total hip arthroplasty
    Bryan Chambers
    Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Arthroplasty 22:71-4. 2007
    ..Although these advantages have not been shown to significantly increase long-term durability, there is sufficient data to support the routine use of HA-coated, tapered cementless femoral stems in THA...
  30. ncbi Early failure of hemispheric hydroxyapatite-coated acetabular cups
    Shin Yoon Kim
    Department of Orthopaedic Surgery, Kyungpook National University, School of Medicine, Daegu, Korea
    Clin Orthop Relat Res 446:233-8. 2006
    ..5%, respectively. Total hip arthroplasties using an hydroxyapatite-coated smooth hemispheric acetabular cup showed an unexpected high failure rate in terms of fixation, occurrence of osteolysis, and revision after midterm followup...
  31. ncbi In vivo effects of RGD-coated titanium implants inserted in two bone-gap models
    Brian Elmengaard
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, AKH, Norrebrogade 44, bygn 1a, DK 8000 Aarhus C, Denmark
    J Biomed Mater Res A 75:249-55. 2005
    ..RGD peptide coatings can potentially be used to enhance tissue integration in these challenging environments...
  32. ncbi Sirolimus-eluting versus paclitaxel-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: a combined RESEARCH and T-SEARCH long-term analysis
    Marco Valgimigli
    Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:507-14. 2006
    ....
  33. ncbi The use of a hydroxyapatite-coated primary stem in revision total hip arthroplasty
    Stephen J Kelly
    Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, University of Vermont, Burlington, Vermont 05405 0084, USA
    J Arthroplasty 21:64-71. 2006
    ..These results are superior to previous reports of primary cementless stems for revision THA. The use of a cementless nonmodular implant provides a viable option in some patients undergoing revision THA...
  34. ncbi Early failure of smooth hydroxyapatite-coated press-fit acetabular cup--7 years of follow-up
    Kin Wing Cheung
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Arthroplasty 20:627-31. 2005
    ..Radiolucent line was not an accurate sign for the detection of mechanical failure...
  35. ncbi Human osteoblast response to pulsed laser deposited calcium phosphate coatings
    A Bigi
    Department of Chemistry G Ciamician, University of Bologna, via Selmi, 2, Bologna 40126, Italy
    Biomaterials 26:2381-9. 2005
    ..Our data demonstrate that both calcium phosphate coatings favour osteoblasts proliferation, activation of their metabolism and differentiation...
  36. ncbi The effect of different titanium and hydroxyapatite-coated dental implant surfaces on phenotypic expression of human bone-derived cells
    Christine Knabe
    Department of Experimental Dentistry, University Hospital Benjamin Franklin, Free University of Berlin, Assmannshauser Str 4 6, 14197 Berlin, FRG
    J Biomed Mater Res A 71:98-107. 2004
    ..Furthermore, Ti-DPS surfaces induced greater osteoblast proliferation and differentiation than Ti-TPS...
  37. ncbi Protein resistance of titanium oxide surfaces modified by biologically inspired mPEG-DOPA
    Jeffrey L Dalsin
    Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Langmuir 21:640-6. 2005
    ....
  38. ncbi An in vitro analysis of a carotid artery stent with a protective porous membrane
    Stefan Muller-Hulsbeck
    Department of Radiology, University Hospital, Arnold Heller Strasse 9, 24105 Kiel, Germany
    J Vasc Interv Radiol 15:1295-305. 2004
    ..To prove the effectiveness of a new stent concept with integrated protection (MembraX [MX]) by comparing it with five cerebral protection devices designed for carotid angioplasty in an in vitro model...
  39. ncbi Grit-blasted and hydroxyapatite-coated total hip arthroplasty: an 11- to 14-year follow-up study
    Shumpei Miyakawa
    Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Science, The University of Tsukuba, 1 1 1 Tennodai, 305 8577, Tsukuba, Japan
    J Orthop Sci 9:462-7. 2004
    ..The suboptimal result of the hydroxyapatite-coated smooth cup indicates that porous coatings under the hydroxyapatite coating would be beneficial for hydroxyapatite-coated total hip implants, especially for the acetabular components...
  40. ncbi Controlled release of insulin from PLGA nanoparticles embedded within PVA hydrogels
    J Liu
    Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China
    J Mater Sci Mater Med 18:2205-10. 2007
    ....
  41. pmc Hip arthroplasty in patients younger than 30 years: excellent ten to 16-year follow-up results with a HA-coated stem
    H Wangen
    Department of Orthopaedics, Rikshospitalet Radiumhospitalet Medical Centre, 0027, Oslo, Norway
    Int Orthop 32:203-8. 2008
    ..In conclusion, we found mechanical failures at the acetabular side, but excellent results with a fully HA-coated femoral stem, with no revisions after ten to 16 years...
  42. ncbi Self-sterilization using silicone catheters coated with Ag and TiO2 nanocomposite thin film
    Yanyan Yao
    Department of Urology and Molecular Science, Graduate School of Medicine, Yokohama City University, 3 9 Fukuura, Yokohama 236 0004, Japan
    J Biomed Mater Res B Appl Biomater 85:453-60. 2008
    ..This type of catheter shows a great promise in lowering the incidence of catheter-related bacterial infections...
  43. ncbi Studies of photokilling of bacteria using titanium dioxide nanoparticles
    Yang Hwei Tsuang
    Department of Orthopedic Surgery, Taipei City Hospital, Taipei, Taiwan
    Artif Organs 32:167-74. 2008
    ..In the presence of UV light, the titanium dioxide nanoparticles can be applicable to medical facilities where the potential for infection should be controlled...
  44. ncbi Vancomycin derivative photopolymerized to titanium kills S. epidermidis
    McKinley C Lawson
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA
    Clin Orthop Relat Res 461:96-105. 2007
    ..This coating method allows a loading dose several thousand times larger than that achieved with monolayer vancomycin coupling approaches and holds promise for the treatment of orthopaedic infections...
  45. pmc Biocompatibility of nanoporous alumina membranes for immunoisolation
    Kristen E La Flamme
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Biomaterials 28:2638-45. 2007
    ..Further, in vivo work has demonstrated that implantation of these capsules into the peritoneal cavity of rats induces a transient inflammatory response, and that PEG is useful in minimizing the host response to the material...
  46. ncbi Modeling of degradation and drug release from a biodegradable stent coating
    Santosh Prabhu
    Cardiac Therapies, Abbott Vascular, Santa Clara, California 95054, USA
    J Biomed Mater Res A 80:732-41. 2007
    ..In addition, this modeling methodology has broader applications and can be used to develop mathematical models for predicting the degradation and drug release kinetics for other polymeric drug delivery systems...
  47. ncbi N-halamine biocidal coatings
    J Liang
    Department of Chemistry, Auburn University, Auburn, AL 36849, USA
    J Ind Microbiol Biotechnol 34:157-63. 2007
    ..Synthetic schemes and biocidal efficacy data are presented. The stabilities of the bound chlorine on the surfaces are also addressed. Substrates employed include sand, textiles, and paint. Potential uses for the technology are discussed...
  48. ncbi Locally delivered TGF-beta1 and IGF-1 enhance the fixation of titanium implants: a study in dogs
    Anders Lamberg
    Department of Orthopaedic Surgery, Aarhus University Hospital, Denmark
    Acta Orthop 77:799-805. 2006
    ..We examined the effect of locally delivered transforming growth factor-beta1 and insulin-like growth factor-1 in a biodegradable poly (D, L-lactide) coating...
  49. ncbi Hydroxyapatite-coated femoral components: 15-year minimum followup
    William N Capello
    Indiana University School of Medicine, Department of Orthopaedic Surgery, 541 Clinical Drive CL600, Indianapolis, IN 46202, USA
    Clin Orthop Relat Res 453:75-80. 2006
    ..6% at 15-year minimum followup. The data demonstrate excellent long-term survivorship of this hydroxyapatite-coated femoral component used in a relatively young patient group...
  50. ncbi Reduced burden of bacterial airway colonization with a novel silver-coated endotracheal tube in a randomized multiple-center feasibility study
    Jordi Rello
    Critical Care Department, Joan XXIII University Hospital, Tarragona, Spain
    Crit Care Med 34:2766-72. 2006
    ..To assess the feasibility and safety of the respiratory infection control (RIC) device, a silver-coated endotracheal tube, and its effect on bacterial burden in the airways...
  51. ncbi Cell fouling resistance of polymer brushes grafted from ti substrates by surface-initiated polymerization: effect of ethylene glycol side chain length
    Xiaowu Fan
    Department of Biomedical Engineering, Robert R McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Illinois 60208, USA
    Biomacromolecules 7:2443-8. 2006
    ....
  52. ncbi Porous-coated cups fixed with screws: a 12-year clinical and radiostereometric follow-up study of 50 hips
    Stephan M Rohrl
    Department of Orthopaedic Surgery, Flinders University and Flinders Medical Centre, Adelaide, Australia
    Acta Orthop 77:393-401. 2006
    ..We evaluated the clinical and radiographic results of 50 patients followed for 12 years...
  53. ncbi Sirolimus-eluting stent in chronic total occlusion: the SICTO study
    Chaim Lotan
    Hadassah Hebrew University Medical Centre, Jerusalem, Israel
    J Interv Cardiol 19:307-12. 2006
    ..The CYPHER sirolimus-eluting stent was safe and effective in the treatment of CTO compared to historical data with bare metal stents...
  54. ncbi Hydroxyapatite coating by sol-gel on Ti-6Al-4V alloy as drug carrier
    Eduardo Peón Avés
    Department of Ceramic and Composites, Centro de Biomateriales, Universidad de La Habana, Havana, Cuba
    J Mater Sci Mater Med 20:543-7. 2009
    ....
  55. ncbi Atomic force microscopy probing platelet activation behavior on titanium nitride nanocoatings for biomedical applications
    Varvara Karagkiozaki
    Department of Physics, Laboratory for Thin Films Nanosystems and Nanometrology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Nanomedicine 5:64-72. 2009
    ..It was found that the TiN(x) films stoichiometry and surface roughness affect the platelet response. The stoichiometric and smoother TiN films promote platelets adhesion and activation...
  56. ncbi Frequency of and risk factors for stent thrombosis after drug-eluting stent implantation during long-term follow-up
    Duk Woo Park
    Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Am J Cardiol 98:352-6. 2006
    ..6%, similar to that for bare metal stents. The predictors of stent thrombosis were premature antiplatelet therapy interruption, primary stenting in acute myocardial infarction, and total stent length...
  57. ncbi Effect of hydroxyapatite coating on risk of revision after primary total hip arthroplasty in younger patients: findings from the Danish Hip Arthroplasty Registry
    Aksel Paulsen
    Department of Orthopaedic Surgery, Odense University Hospital, University of Southern Denmark, Denmark
    Acta Orthop 78:622-8. 2007
    ..The effect of hydroxyapatite (HA) on implant survival in the medium and long term is uncertain. We studied the effect of HA coating of uncemented implants on the risk of cup and stem revision in primary total hip arthroplasty (THA)...
  58. ncbi Long-term results of HA coated threaded versus HA coated hemispheric press fit cups: 287 hips followed for 11 to 16 years
    Olav Reikeras
    Orthopaedic Department, Rikshospitalet University Clinic, 0027 Oslo, Norway
    Arch Orthop Trauma Surg 126:503-8. 2006
    ..In this paper, we report 11 to 16 years follow up results of HA coated threaded versus HA coated hemispherical press fit cups...
  59. ncbi Surface engineering approaches to micropattern surfaces for cell-based assays
    Didier Falconnet
    BioInterfaceGroup, Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Biomaterials 27:3044-63. 2006
    ....
  60. ncbi Influence of silicon concentration on the haemocompatibility of amorphous carbon
    Soon Eng Ong
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Biomaterials 28:4033-8. 2007
    ..Bonding structure and surface energy were determined to be factors contributing to the improved haemocompatibility...
  61. ncbi Plasma-mediated grafting of poly(ethylene glycol) on polyamide and polyester surfaces and evaluation of antifouling ability of modified substrates
    Baiyan Dong
    Center for Plasma Aided Manufacturing, 1410 Engineering Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    Langmuir 23:7306-13. 2007
    ..This plasma functionalization method provided an efficient way to graft PEG onto PA and PET surfaces. Because of the high reactivity of Si-Cl species, this method could potentially be applied to other polymeric materials...
  62. ncbi Risk of thrombosis with the use of sirolimus-eluting stents for percutaneous coronary intervention (from registry and clinical trial data)
    Anthony A Bavry
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 95:1469-72. 2005
    ..Compared with bare metal stents, sirolimus-eluting stents did not appear to increase the risk for thrombosis up to 13.5 months after coronary intervention (risk ratio 0.49, 95% confidence interval 0.22 to 1.12, p = 0.09)...
  63. ncbi High wear rates and extensive osteolysis in 3 types of uncemented total hip arthroplasty: a review of the PCA, the Harris Galante and the Profile/Tri-Lock Plus arthroplasties with a minimum of 12 years median follow-up in 96 hips
    Geir Hallan
    Department of Orthopaedic Surgery, Haukeland University Hospital Bergen Norway
    Acta Orthop 77:575-84. 2006
    ..High wear rates and femoral and acetabular osteolysis have been-and still are-the main problems in uncemented total hip replacement. We reviewed 96 consecutive cementless total hip replacements of 4 different designs...
  64. pmc Polymerizable vancomycin derivatives for bactericidal biomaterial surface modification: structure-function evaluation
    McKinley C Lawson
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA
    Biomacromolecules 10:2221-34. 2009
    ..In particular, the vancomycin-PEG-acrylate derivatives demonstrated a 7-8 log reduction in bacterial colony forming units (CFU) with respect to nonfunctionalized control surfaces...
  65. ncbi Polyelectrolyte multilayer films with pegylated polypeptides as a new type of anti-microbial protection for biomaterials
    F Boulmedais
    Institut Charles Sadron, UPR 22 CNRS, 6 rue Boussingault, 67083 Strasbourg Cedex, France
    Biomaterials 25:2003-11. 2004
    ..This kind of anti-adhesive films represents a new and very simple method to coat any type of biomaterials for protection against bacterial adhesion and therefore limiting its pathological consequences...
  66. ncbi Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions
    Antonio Colombo
    Ospedale San Raffaele, Milano, Italy
    Circulation 108:788-94. 2003
    ..Early clinical studies demonstrated the feasibility of local paclitaxel delivery in reducing restenosis after treatment of de novo coronary lesions in small patient populations...
  67. ncbi Survival and polyethylene wear of porous-coated acetabular components in patients less than fifty years old: results at nine to fourteen years
    James D Crowther
    Department of Orthpaedics, University of North Carolina, Chapel Hill 27599, USA
    J Bone Joint Surg Am 84:729-35. 2002
    ..In this report, we present the results associated with the use of an uncemented acetabular component in young patients who were evaluated at a minimum of nine years postoperatively...
  68. ncbi The impact of heparin-coated cardiopulmonary bypass circuits on pulmonary function and the release of inflammatory mediators
    R de Vroege
    Departments of Extracorporeal Circulation, Room 6A 149, Vrije Universiteit Medisch Centrum, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Anesth Analg 98:1586-94, table of contents. 2004
    ..The correlation with sPLA(2), leukocyte activation, and postoperative leukocyte count suggests reduced activation of pulmonary capillary endothelial cells...
  69. ncbi Reduction in neointimal formation with a stent coated with multiple layers of releasable heparin in porcine coronary arteries
    Yasuharu Matsumoto
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Cardiovasc Pharmacol 39:513-22. 2002
    ..8 +/- 1.0) than at the control stent site (19.1 +/- 1.7) (p < 0.01). These results suggest that the stent coated with releasable heparin is beneficial in reducing neointimal formation and subsequent in-stent restenosis...
  70. ncbi Silver-coated endotracheal tubes associated with reduced bacterial burden in the lungs of mechanically ventilated dogs
    Merle E Olson
    Department of Microbiology and Infectious Diseases, Animal Resources Center, The University of Calgary, Alberta, Canada
    Chest 121:863-70. 2002
    ..To evaluate the influence of silver-coated endotracheal tubes on the lung bacterial burden of mechanically ventilated dogs...
  71. ncbi Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity
    M Bosetti
    Department of Medical Sciences, Human Anatomy, University of Eastern Piemonte, Novara, Italy
    Biomaterials 23:887-92. 2002
    ..Based on these and the previous bacterial studies it seems like the toxicity towards bacteria was quite a bit greater than that towards the human cells...
  72. ncbi Cementless Spotorno tapered titanium stems: excellent 10-15-year survival in 141 young patients
    Peter R Aldinger
    Stiftung Orthopädische Universitätsklinik Heidelberg, Schlierbacher Landstrasse 200a, DE 69118 Heidelberg, Germany
    Acta Orthop Scand 74:253-8. 2003
    ..However, the high rate of cup loosening and the low Harris hip scores are a concern in this subgroup of young patients...
  73. ncbi Effects of solution pH and electrical parameters on hydroxyapatite coatings deposited by a plasma-assisted electrophoresis technique
    X Nie
    Research Centre in Surface Engineering, University of Hull, Hull, HU6 7RX, UK
    J Biomed Mater Res 57:612-8. 2001
    ..Such a nanophase TiO2 layer (if used as a coating alone) may also provide a further improvement in osteoinductive properties, compared to a conventional TiO2 coating on the Ti alloy substrate...
  74. ncbi Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model
    H Suhara
    Department of Surgery, Osaka University Graduate School of Medicine, Japan
    Ann Thorac Surg 71:1603-8. 2001
    ..Thus, PMEA coating may be a suitable means for improving the biocompatibility of CPB circuits...
  75. ncbi Hydroxyapatite-coated acetabular components. Histological and histomorphometric analysis of six cups retrieved at autopsy between three and seven years after successful implantation
    A Tonino
    Department of Orthopaedics, De Wever Hospital, Heerlen, The Netherlands
    J Bone Joint Surg Am 83:817-25. 2001
    ....
  76. ncbi Malignant biliary obstruction: treatment with ePTFE-FEP- covered endoprostheses initial technical and clinical experiences in a multicenter trial
    Maria Schoder
    Department of Angiography and Interventional Radiology, University of Vienna Medical School, Waehringerguertel 18 20, A 1090 Vienna, Austria
    Radiology 225:35-42. 2002
    ..To determine and present the initial technical and clinical results of using an expanded polytetrafluoroethylene-fluorinated ethylene propylene (ePTFE-FEP)-covered biliary endoprosthesis to treat malignant biliary obstruction...
  77. ncbi The odyssey of porous-coated fixation
    Charles A Engh
    Anderson Orthopedic Research Institute, Alexandria, Virginia 22307, USA
    J Arthroplasty 17:102-7. 2002
    ..Because of the relatively easy, reproducible surgical technique associated with extensively porous-coated stems and the perception of marginally better outcome, we prefer to use extensively porous-coated stems for all primary THAs...
  78. ncbi Influence of surface modifications to titanium on antibacterial activity in vitro
    M Yoshinari
    Department of Dental Materials Science and Oral Health Science Center, Tokyo Dental College, Chiba, Japan
    Biomaterials 22:2043-8. 2001
    ..These findings indicate that surface modification by means of a dry process is useful in providing antibacterial activity of oral bacteria to titanium implants exposed to the oral cavity...
  79. ncbi Biocompatilibity-related surface characteristics of oxidized NiTi
    Anatoli Danilov
    Department of Medical Technology, University of Oulu, PO Box 5000, Oulu, Finland
    J Biomed Mater Res A 82:810-9. 2007
    ..The comparative oxidation of pure titanium and NiTi showed that the effect of Ni on the EWF value of NiTi surface oxide is negligible...
  80. ncbi Degradation characteristics of hydroxyapatite coatings on orthopaedic TiAlV in simulated physiological media investigated by electrochemical impedance spectroscopy
    Ricardo M Souto
    Department of Physical Chemistry, University of La Laguna, Campus de Anchieta, E 38071 Tenerife, Canary Islands, La Laguna, Spain
    Biomaterials 24:4213-21. 2003
    ..The blocking effect due to salt precipitation inside the pores produces an enhancement of the resistance values, thus effectively diminishing the metal ion release in the system...
  81. ncbi Processing-microstructure-property relations in HVOF sprayed calcium phosphate based bioceramic coatings
    K A Khor
    School of Mechanical and Production Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Biomaterials 24:2233-43. 2003
    ..The relationship among the processing, microstructure, and mechanical properties of the HVOF sprayed bioceramic coatings was summarily examined...
  82. ncbi Improved bone ingrowth and fixation with a thin calcium phosphate coating intended for complete resorption
    O Reigstad
    Orthopaedic Department, Rikshospitalet National Hospital, 0027 Oslo, Norway
    J Biomed Mater Res B Appl Biomater 83:9-15. 2007
    ..This unloaded short-term study has shown promising results for the easily applicable and resorbable coat (Bonit) compared to uncoated titanium-alloy implants...
  83. ncbi Biological responses in osteoblast-like cell line according to thin layer hydroxyapatite coatings on anodized titanium
    S H Sohn
    Department of Biochemistry, College of Medcine, Korea University, Seongbuk gu, Seoul, Korea
    J Oral Rehabil 33:898-911. 2006
    ..The attachment and expression of key osteogenic regulatory genes were enhanced by the surface morphology of the dental materials used...
  84. ncbi Properties and immersion behavior of magnetron-sputtered multi-layered hydroxyapatite/titanium composite coatings
    Shinn Jyh Ding
    Institute of Dental Materials, Chung Shan Medical University, Taichung, 402, Taiwan ROC
    Biomaterials 24:4233-8. 2003
    ..The adhesion strength higher than 60MPa did not change much even after 14 weeks of immersion. The multi-layered composite coatings had the advantages of high and non-declining adhesion strength and high resistance to SBF attack...
  85. ncbi Quantification of fibrinogen adsorption onto 316L stainless steel
    Robert T T Gettens
    Department of Biomedical and Chemical Engineering, Syracuse University, Link Hall 121, Syracuse, New York 13244, USA
    J Biomed Mater Res A 81:465-73. 2007
    ..Complete area coverage was never obtained. That is, after adsorption for over 5 time constants (5tau), voids in the structure were always observed...
  86. ncbi Biocompatibility of electrophoretical deposition of nanostructured hydroxyapatite coating on roughen titanium surface: in vitro evaluation using mesenchymal stem cells
    F Chen
    State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, Xiamen University, Xiamen 361005, China
    J Biomed Mater Res B Appl Biomater 82:183-91. 2007
    ..Proliferation of the MSCs on the nano-HAp coating was higher than its micron counterpart in XTT assay. These properties show potential for the orthopaedic and dental applications...
  87. ncbi Evaluation of corrosion on plasma sprayed and anodized titanium implants, both with and without bone cement
    L Reclaru
    Groupe PX, PX Tech, Bldv des Eplature 46, La Chaux de Fonds 2304, Switzerland
    Biomaterials 24:3027-38. 2003
    ..We cannot deduce from our results, however, whether the polymer itself possesses corrosive properties. Long-term experiments will be necessary to study the degradation behavior of the polymer cement...
  88. ncbi The effects of conductivity and electrochemical doping on the reduction of methemoglobin immobilized in nanoparticulate TiO2 films
    Elizabeth V Milsom
    Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Bioelectrochemistry 70:221-7. 2007
    ..TiO(2) can be temporarily switched from a non-conducting (irreversible electron transfer) into a conducting (reversible electron transfer) state...
  89. ncbi Preparation and osteocompatibility of hydroxyapatite coated on titanium from the reaction of sputtered CaO and vaporized P2O5
    K Ozeki
    Applied Systems Engineering, Graduate School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama, 350 0394, Japan
    Biomed Mater Eng 13:83-90. 2003
    ....
  90. ncbi In vitro corrosion behavior of bioceramic, metallic, and bioceramic-metallic coated stainless steel dental implants
    M H Fathi
    Department of Materials Engineering, Isfahan University of Technology, 84154, Isfahan, Iran
    Dent Mater 19:188-98. 2003
    ..The aim of this work was to evaluate the corrosion behavior and thus the biocompatibility of the uncoated and coated stainless steels and compare the effect of type of coatings on corrosion behavior...
  91. ncbi Effects of ion beam-assisted deposition of hydroxyapatite on the osseointegration of endosseous implants in rabbit tibiae
    Y C Jung
    Department of Dentistry, St Vincent's Hospital, School of Medicine, The Catholic University of Korea, Seoul
    Int J Oral Maxillofac Implants 16:809-18. 2001
    ..05)...
  92. ncbi Deposition of nano-hydroxyapatite particles utilising direct and transitional electrohydrodynamic processes
    Z Ahmad
    Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK
    J Mater Sci Mater Med 19:3093-104. 2008
    ..The results indicate the robustness of the electrohydrodynamic route in the nano-materials processing arena, with emphasis on biomedical materials...
  93. ncbi Hydroxyapatite coatings produced on commercially pure titanium by micro-arc oxidation
    Yong Huang
    College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People s Republic of China
    Biomed Mater 2:196-201. 2007
    ..The favorable osteoblast cell affinity gives HA film good biocompatibility. HA coatings are expected to have significant uses for medical applications such as dental implants and artificial bone joints...
  94. ncbi Hydroxyapatite coating on Ti6Al4V alloy by a sol-gel method
    Diangang Wang
    School of Materials Science and Engineering, Shandong University, Jinan, 250061, P R China
    J Mater Sci Mater Med 19:2281-6. 2008
    ....
  95. ncbi Electrohydrodynamic coating of metal with nano-sized hydroxyapatite
    Xiang Li
    Department of Mechanical Engineering, University College London, London, UK
    Biomed Mater Eng 17:335-46. 2007
    ..Therefore, we have uncovered a new procedure by which nano-biomaterials can be deposited on real orthopedic substrates to prepare bioactive thin coatings in a simple and easy manner...
  96. ncbi Development of nano-hydroxyapatite coating by electrohydrodynamic atomization spraying
    Xiang Li
    Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK
    J Mater Sci Mater Med 19:1545-51. 2008
    ..3 kV and 5.2 kV, a uniform nHA coating was obtained. This is a crucial step forward in obtaining advanced nano-hydroxyapatite coatings of high quality for biomedical applications by using EHDA spraying...
  97. ncbi [Bioactive films for biomaterial coating and intended for tissue engineering: new original methods?]
    P Schaaf
    Institut Charles Sadron, ULP CNRS UPR22, 6, rue Boussingault, 67083 Strasbourg, France
    Pathol Biol (Paris) 50:189-93. 2002
    ..Combined with a high affinity for calcium or phosphate complexing properties such functionalized architectures could constitute an original way to favour osseointegration...
  98. ncbi Thin films of SiO2 and hydroxyapatite on titanium deposited by spray pyrolysis
    V Jokanovic
    Institute of Nuclear Sciences Vinca Laboratory for Radiation Chemistry and Physics, P O Box 522, Belgrade 11001, Republic of Serbia
    J Mater Sci Mater Med 19:1871-9. 2008
    ..A hydroxyapatite film was prepared on the so-obtained SiO2 thin film by spray pyrolysis deposition and its morphology and phase composition were investigated...
  99. ncbi Preparation and characteristics of nano-grained calcium phosphate coatings on titanium from ultrasonated bath at acidic pH
    R Narayanan
    Department of Dental Biomaterials, College of Dentistry, Institute for Biomaterials Research and Development, KNU School of Dentistry BK21, Kyungpook National University, Daegu, Korea
    J Biomed Mater Res B Appl Biomater 85:231-9. 2008
    ..Heat-treatment of the coatings for 2 h at 500 degrees C completely eliminated the dicalcium phosphate phase and resulted in mono hydroxyapatite phase containing grains in the size range of 20-30 nm...
  100. ncbi Preparation of an electrodeposited hydroxyapatite coating on titanium substrate suitable for in-vivo applications
    Suping Huang
    State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan 410083, PR China
    J Mater Sci Mater Med 19:437-42. 2008
    ..05), which demonstrated that HA-coated Ti has a good biocompatibility...
  101. ncbi Nucleation and growth of apatite on chemically treated titanium alloy: an electrochemical impedance spectroscopy study
    C X Wang
    School of Mechanical and Production Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore
    Biomaterials 24:3069-77. 2003
    ..It was found that EIS is a useful method for investigating the nucleation and growth of bone-like apatite on Ti6Al4V pretreated with NaOH solution...

Research Grants62

  1. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  2. PACING, SENSING AND DEFIBRILLATION ELECTRODE COATINGS
    Stuart Cogan; Fiscal Year: 2006
    ..The in vivo studies will be done with collaborators at the University of Alabama. [unreadable] [unreadable]..
  3. Electrodeposited Noble Metal Oxide Nerve Electrodes
    Stuart Cogan; Fiscal Year: 2006
    ..abstract_text> ..
  4. Conductive Polymer Recording and Stimulation Electrodes
    Stuart Cogan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  5. MODEL FOR ELECTRODE TESTING AND REDUCED ANIMAL USE
    Stuart Cogan; Fiscal Year: 2003
    ..The validity of the inanimate and living models will be evaluated by comparison of electrode function in the in vitro models with that observed under identical test protocols in the chronic cat cortex. ..
  6. Functionalized Coatings for Enhanced Neural Interfaces
    Stuart Cogan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
  8. Biomimetic Scaffolds for Abdominal Wall Repair
    Anshu Mathur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. Targeted Delivery of Anthrax Inhibitors
    Marina Backer; Fiscal Year: 2007
    ..In Phase II we will develop LFn-liposomes with combination of LF and EF inhibitors, validate these liposomes in animal models of anthrax infection, and pre-clinical steps required for IND filing. [unreadable] [unreadable] [unreadable]..
  10. Ultrasound Monitoring of Rat Metastatic Uveal Melanoma
    RODNEY BRAUN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  12. Detection of Topoisomerase II Mediated DNA Damage in Stroke
    VLADIMIR DIDENKO; Fiscal Year: 2007
    ..It will also have a broad applicability in all fields of biomedicine where detection of early apoptosis is important. [unreadable] [unreadable] [unreadable]..
  13. Glial Biology Gordon Research Conference
    Vladimir Parpura; Fiscal Year: 2007
    ..This Glial Biology Conference provides an international forum for emerging, innovative research related to glia functions and cell-cell interactions in health and disease. ..
  14. Development of Magnetic Sensors for MRI Cancer Imaging
    J Perez; Fiscal Year: 2007
    ..The proposed research will be conducted in a multidisciplinary environment and the integrated training and research program will enable the candidate to establish himself as an independent cancer researcher. [unreadable] [unreadable]..
  15. Multiaxial Single-Cell Biomechanics for Mechanotransduction
    SEAN KOHLES; Fiscal Year: 2007
    ..contribute to the understanding of pathologic cell states and therapeutic approaches for load-bearing tissues, and guide the design of engineered biomaterials which control cellular function [unreadable] [unreadable] [unreadable]..
  16. Semi-artificial nanomachines for detection of DNA damage and apoptosis
    VLADIMIR DIDENKO; Fiscal Year: 2008
    ..abstract_text> ..
  17. Cellular MRI in Glioma and Radiation Necrosis
    Ali Syed Arbab; Fiscal Year: 2010
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..
  18. Real-time MRI-guided RF Ablation of Cardiac TachyArrhythmias
    Orhan Unal; Fiscal Year: 2010
    ..Successful completion of this project is expected to improve safety, simplicity, and efficacy catheter ablation procedure to treat AF. ..
  19. Semiconductor Nanosensors for Label-Free Detection of Antigens and Cellular Immun
    Mark Reed; Fiscal Year: 2010
    ..These nanosensors can replace current technology with a powerful solid-state device useful for rapid diagnosis in clinical settings. ..
  20. BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBES
    James F Rusling; Fiscal Year: 2010
    ..In addition to achieving our specific aims, this project should provide fundamental guidance for fabrication of sensitive microarray devices for a wide variety of biomedical applications. ..
  21. Orchestrating Bone Regeneration on Multiple Scales
    Peter X Ma; Fiscal Year: 2010
    ..SA 3. Confirm that the multi-scaled and factor-releasing scaffolds (selected from Aims 1&2) afford a superior environment for vascularized bone regeneration in a rat critical defect model. ..
  22. Towards the development of a "living" cochlear implant
    Xuejun Wen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. IMPROVING THE DETECTION LIMIT OF POTENTIOMETRIC SENSORS
    Joseph Wang; Fiscal Year: 2008
    ..The perturbance of such fluxes by surface binding events will be used to explore novel approaches to biosensing at liquid-polymer interfaces. ..
  24. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2008
    ..This magnetic labeling technique will also help investigators to track the injected CTL in the body as well as in the targeted areas by magnetic resonance imaging (MRI). [unreadable] [unreadable] [unreadable]..
  25. Nano Fibers for ADME/Toxicology
    Peter Ma; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Targeting GRP78/BIP As An Adjunct Therapy For EGFR-positive Breast Cancer
    Marina Backer; Fiscal Year: 2008
    ..We expect that this data establish feasibility of clinical development for EGF-SLiP. [unreadable] [unreadable] [unreadable]..
  27. Engineered neuronal networks for drug screening
    Peter Molnar; Fiscal Year: 2008
    ..abstract_text> ..
  28. Pathogenesis of Experimental Necrotizing Enterocolitis
    Henri Ford; Fiscal Year: 2006
    ..III) To determine the effects of scavengers of NO or inhibitors of NO production on the development of experimental rodent NEC. ..
  29. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  30. Composition/Functional Elasticity of Engineered Tissues
    SEAN KOHLES; Fiscal Year: 2003
    ..The results will be used to predict the time-dependent performance of cell-polymer constructs, and to gain insight into the mechanisms of scaffold degradation and ECM synthesis...
  31. Physical Regulation of Skeletal Repair Workshop
    Roy Aaron; Fiscal Year: 2003
    ..Finally, how repairing skeletal tissues organize physical information to augment the repair process, and what translational opportunities exist, will be considered. ..
  32. STRUCTURES OF ACETYLCHOLINE RECEPTORS
    Arthur Karlin; Fiscal Year: 2003
    ..The Cys will be substituted for residues known to contribute to the binding of ACh. ..
  33. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  34. Biomimetic Nano Scaffolds
    Peter Ma; Fiscal Year: 2004
    ..This knowledge will enable us to develop a predictable biomimetic scaffold for in vivo application and will be the basis for our planned R01 investigation. ..
  35. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2004
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. ..
  36. Osteoblast response to strain at implant-tissue interfac
    Joel Bumgardner; Fiscal Year: 2003
    ..Furthermore, it may also be useful in identifying loading parameters that promote osteointegration. ..
  37. EXERCISE AND CARDIOVASCULAR DISEASE
    William Weintraub; Fiscal Year: 2003
    ..Not only existing markers of oxidative stress, but also novel surrogate markers, such as, plasma soluble VCAM-l, myeloperoxidase, and autoantbodies to oxidatively modified proteins will be measured. ..
  38. Coating Reduces Encrustation on Urethral Stent
    Shih Horng Su; Fiscal Year: 2004
    ..Ureteral stents equipped with the anti-encrustation coating will be compared to many similar products on the market in the aspect of encrustation severity. The data will guide future optimization. ..
  39. Analysis & Control of Non-Synaptic Epileptiform Activity
    Dominique Durand; Fiscal Year: 2004
    ..The results of our studies should provide valuable insight into mechanisms underlying epileptogenesis as well as new tools for the control and suppression of epileptic seizures. ..
  40. Effect of defined surfaces on cardiac myocyte physiology
    Peter Molnar; Fiscal Year: 2004
    ..Results obtained in this study would have a high impact on the progress of the emerging new cardiac tissue engineering methods. ..
  41. SELECTINS ROLE IN VASCULAR INJURY IN GENE-TARGETED
    Ian Sarembock; Fiscal Year: 2004
    ..In addition, these studies will open new avenues to potential therapeutic strategies to limit neointimal growth after vascular injury. ..
  42. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....
  43. ROLES OF NITRIC OXIDE AND OXYGEN IN OCULAR MELANOMA
    RODNEY BRAUN; Fiscal Year: 2002
    ....
  44. Optimization of Cure Efficiency in Polymeric Biomaterial
    Lawrence Musanje; Fiscal Year: 2006
    ..A light emitting diode (LED) whose emission adequately overlaps the absorption spectrum of photosensitizer will be chosen. ..
  45. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  46. Novel Biomaterials Guiding Supercrestal Bone Growth
    Mei Wei; Fiscal Year: 2008
    ..This will also improve the reliability of the surgery and reduce the risk, pain and disruption associated with bone augmentation [unreadable] [unreadable] [unreadable]..
  47. Calcium-dependent glutamate release from astrocytes
    Vladimir Parpura; Fiscal Year: 2008
    ..Since astrocytes modulate synaptic transmission by releasing glutamate, this new insight into glial action has potential to change the way we think about central nervous system functions and dysfunctions [unreadable] [unreadable]..
  48. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  49. Estrogen: Chrodroprotective or Destructive?
    Sally Frenkel; Fiscal Year: 2002
    ..The inconclusive and contradictory data from human and animal studies render the proposed studies highly significant. ..
  50. FUNDAMENTALS OF SURGICAL RESEARCH COURSE
    Henri Ford; Fiscal Year: 2008
    ..Therefore, promoting, educating and training the young surgical investigator in the responsible conduct of research is an essential component of the Fundamentals of Surgical Research Course. ..
  51. Quantifying Axon Growth in Complex Environments
    Diane Hoffman Kim; Fiscal Year: 2010
    ..The proposed research seeks to solve this problem by quantifying how guidance cues, both individually and in combination, promote axon growth in an inhibitory environment such as a nerve injury site. ..
  52. Biomechanics on Neutrophil Rolling on the Endothelium
    Jin Yu Shao; Fiscal Year: 2006
    ..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
  53. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. [unreadable] [unreadable]..
  54. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  55. Antiatherogenic Properties of tert-Butylhydroquinone
    William Stone; Fiscal Year: 2004
    ..Commercial development should be accelerated since NIH has already conducted extensive toxicological studies with TBHQ. ..
  56. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008
    ..abstract_text> ..
  57. ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEA
    Dominique Durand; Fiscal Year: 2004
    ..It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA. ..
  58. Free radicals detection in aging brain by fullerenes
    VLADIMIR DIDENKO; Fiscal Year: 2003
    ..At a later stage free radicals will be monitored using magnetic resonance tracer and MRI detection. ..
  59. Mesoporus Diamondlike Carbon Medical Device Membrane
    Roger Narayan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. MULTIPHOTON BIOMEDICAL NANOFABRICATION
    Paul Campagnola; Fiscal Year: 2001
    ..3) To fabricate dimensionally complex channels and structures for applications to microfluidics. 4) To fabricate composites and biomaterials for tissue engineering. ..
  61. Tissue protein imaging via second harmonic generaton
    Paul Campagnola; Fiscal Year: 2006
    ..iii) Determine ideal optical parameters for SHG imaging of tissues in vivo. ..
  62. MULTIPHOTON BIOMEDICAL NANOFABRICATION
    Paul Campagnola; Fiscal Year: 2003
    ..3) To fabricate dimensionally complex channels and structures for applications to microfluidics. 4) To fabricate composites and biomaterials for tissue engineering. ..