biocompatible materials

Summary

Summary: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.

Top Publications

  1. ncbi Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    M P Lutolf
    Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 23:47-55. 2005
  2. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
  3. pmc Foreign body reaction to biomaterials
    James M Anderson
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, United States
    Semin Immunol 20:86-100. 2008
  4. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
  5. ncbi In vitro toxicity evaluation of graphene oxide on A549 cells
    Yanli Chang
    Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
    Toxicol Lett 200:201-10. 2011
  6. ncbi Osteoblast adhesion on biomaterials
    K Anselme
    Institut de Recherche sur les Maladies du Squelette, Institut Calot, Berck sur Mer, France
    Biomaterials 21:667-81. 2000
  7. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005
  8. pmc Designing materials to direct stem-cell fate
    Matthias P Lutolf
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nature 462:433-41. 2009
  9. ncbi The design of scaffolds for use in tissue engineering. Part I. Traditional factors
    S Yang
    Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore
    Tissue Eng 7:679-89. 2001
  10. ncbi Synthetic biodegradable polymers as orthopedic devices
    J C Middleton
    Birmingham Polymers, Inc, AL 35211, USA
    Biomaterials 21:2335-46. 2000

Detail Information

Publications325 found, 100 shown here

  1. ncbi Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    M P Lutolf
    Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 23:47-55. 2005
    ....
  2. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
    ..In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies...
  3. pmc Foreign body reaction to biomaterials
    James M Anderson
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, United States
    Semin Immunol 20:86-100. 2008
    ....
  4. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
    ..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
  5. ncbi In vitro toxicity evaluation of graphene oxide on A549 cells
    Yanli Chang
    Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
    Toxicol Lett 200:201-10. 2011
    ..These effects are dose and size related, and should be considered in the development of bio-applications of GO. Overall, GO is a pretty safe material at cellular level, which is confirmed by the favorable cell growth on GO film...
  6. ncbi Osteoblast adhesion on biomaterials
    K Anselme
    Institut de Recherche sur les Maladies du Squelette, Institut Calot, Berck sur Mer, France
    Biomaterials 21:667-81. 2000
    ....
  7. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005
    ..Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration...
  8. pmc Designing materials to direct stem-cell fate
    Matthias P Lutolf
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nature 462:433-41. 2009
    ..Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration...
  9. ncbi The design of scaffolds for use in tissue engineering. Part I. Traditional factors
    S Yang
    Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore
    Tissue Eng 7:679-89. 2001
    ..Advantages and limitations of these traditional methods are also discussed...
  10. ncbi Synthetic biodegradable polymers as orthopedic devices
    J C Middleton
    Birmingham Polymers, Inc, AL 35211, USA
    Biomaterials 21:2335-46. 2000
    ..An overview of biocompatibility and approved devices of particular interest in orthopedics are also covered...
  11. ncbi Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Huanan Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
    Biomaterials 28:3338-48. 2007
    ..All these results indicate that the scaffolds fulfill the basic requirements of bone tissue engineering scaffold, and have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery...
  12. ncbi Designing materials for biology and medicine
    Robert Langer
    Department of Chemical Engineering, Massachusetts Institute of Technology, Building E25 342, Cambridge, Massachusetts 02139, USA
    Nature 428:487-92. 2004
    ..These include synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies...
  13. ncbi Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds
    E Sachlos
    Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
    Eur Cell Mater 5:29-39; discussion 39-40. 2003
    ..The vascular system allows for the supply of nutrients and oxygen throughout the scaffold. The future of tissue engineering scaffolds is intertwined with SFF technologies...
  14. ncbi Tissue engineering--current challenges and expanding opportunities
    Linda G Griffith
    Department of Chemical Engineering, Division of Bioengineering and Environmental Health, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 295:1009-14. 2002
    ....
  15. ncbi Third-generation biomedical materials
    Larry L Hench
    Department of Materials and the Tissue Engineering Centre, Imperial College of Science, Technology and Medicine, University of London, Prince Consort Road, London SW7 2BP, UK
    Science 295:1014-7. 2002
    ....
  16. ncbi On the mechanisms of biocompatibility
    David F Williams
    University of Liverpool, UK
    Biomaterials 29:2941-53. 2008
    ..It is believed that once the need for this change is recognised, so our understanding of the mechanisms of biocompatibility will markedly improve...
  17. pmc Inspiration and application in the evolution of biomaterials
    Nathaniel Huebsch
    School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, 319 Pierce Hall, Cambridge, Massachusetts 02138, USA
    Nature 462:426-32. 2009
    ..In the future, biomaterials will assume an even greater role in medicine and will find use in a wide variety of non-medical applications through biologically inspired design and incorporation of dynamic behaviour...
  18. ncbi Freezing as a path to build complex composites
    Sylvain Deville
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 311:515-8. 2006
    ....
  19. pmc Relationships among cell attachment, spreading, cytoskeletal organization, and migration rate for anchorage-dependent cells on model surfaces
    K Webb
    W. M. Keck Center for Tissue Engineering, Center for Biopolymers at Interfaces, Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    J Biomed Mater Res 49:362-8. 2000
    ....
  20. ncbi Electrospun nanofibrous structure: a novel scaffold for tissue engineering
    Wan Ju Li
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 60:613-21. 2002
    ..This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth...
  21. ncbi Collagen--biomaterial for drug delivery
    W Friess
    University of Erlangen, Germany
    Eur J Pharm Biopharm 45:113-36. 1998
    ..However, the scientific information about manipulating release properties or mechanistic studies is not as abundant as for some synthetic polymers...
  22. ncbi Silk-based biomaterials
    Gregory H Altman
    Department of Chemical and Biological Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 24:401-16. 2003
    ..With the diversity of silk-like fibrous proteins from spiders and insects, a range of native or bioengineered variants can be expected for application to a diverse set of clinical needs...
  23. ncbi A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics
    Alexander Hoppe
    Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
    Biomaterials 32:2757-74. 2011
    ..Cells investigated in the reviewed articles include human osteoblastic and osteoclastic cells as well as endothelial cells and stem cells...
  24. ncbi Rapid prototyping in tissue engineering: challenges and potential
    Wai Yee Yeong
    Rapid Prototyping Research Laboratory, Design Research Centre, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore 639798
    Trends Biotechnol 22:643-52. 2004
    ..The potential and challenges of scaffold-based technology are discussed from the perspective of RP technology...
  25. ncbi Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation
    X M Mo
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore
    Biomaterials 25:1883-90. 2004
    ..The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds...
  26. ncbi Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells
    S P Bruder
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    J Orthop Res 16:155-62. 1998
    ..These studies demonstrate that human mesenchymal stem cells can regenerate bone in a clinically significant osseous defect and may therefore provide an alternative to autogenous bone grafts...
  27. ncbi The effect of pore size on cell adhesion in collagen-GAG scaffolds
    F J O'Brien
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 8 135, Cambridge, MA 02139, USA
    Biomaterials 26:433-41. 2005
    ..9-150.5 microm) of pore sizes for MC3T3 cells...
  28. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
    ....
  29. ncbi Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo
    Thomas J Webster
    Department of Biomedical Engineering, Purdue University, 1296Patter Building, West Lafayette, IN 47905, USA
    Biomaterials 25:4731-9. 2004
    ....
  30. ncbi A multiparametric assay to compare the cytotoxicity of endodontic sealers with primary human osteoblasts
    M Z Scelza
    Laboratory of Experimental Cell Culture, Department of Endodontics, Fluminense Federal University UFF, Niteroi, RJ Brazil
    Int Endod J 45:12-8. 2012
    ....
  31. ncbi Complexity in biomaterials for tissue engineering
    Elsie S Place
    Department of Materials, Imperial College London, London SW7 2AZ, UK
    Nat Mater 8:457-70. 2009
    ..In the future these exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering...
  32. pmc Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
    Benjamin G Keselowsky
    Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 102:5953-7. 2005
    ....
  33. ncbi Magnesium hydroxide temporarily enhancing osteoblast activity and decreasing the osteoclast number in peri-implant bone remodelling
    C Janning
    Laboratory for Biomechanics and Biomaterials, Department of Orthopaedic Surgery, Hannover Medical School, Anna von Borries Strasse 1 7, 30625 Hannover, Germany
    Acta Biomater 6:1861-8. 2010
    ..Further studies have to evaluate if the enhanced bone growth is mainly due to the local magnesium ion concentration or the local alkalosis accompanying the Mg(OH)(2) dissolution...
  34. ncbi The application of polyhydroxyalkanoates as tissue engineering materials
    Guo Qiang Chen
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biomaterials 26:6565-78. 2005
    ..This paper reviews what have been achieved in the PHA tissue engineering area and concluded that the PHA prospective will look very bright in the near future...
  35. pmc Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation
    Joshua R Mauney
    Department of Urology, Urological Diseases Research Center, Children s Hospital Boston, Boston, MA 02115, USA
    Biomaterials 32:808-18. 2011
    ..These results provide evidence for the utility of gel spun silk-based matrices for functional bladder tissue engineering applications...
  36. ncbi Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2
    J Patterson
    Institute for Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Biomaterials 31:7836-45. 2010
    ..These faster degrading gels should provide matrices that are easier for cells to remodel and lead to increased cellular infiltration and potentially more robust healing in vivo...
  37. pmc Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells
    Ying Mei
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Mater 9:768-78. 2010
    ..The structure-function methodology employed herein provides a general framework for the combinatorial development of synthetic substrates for stem cell culture...
  38. pmc Biomimetic materials for tissue engineering
    Peter X Ma
    Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109 1078, USA
    Adv Drug Deliv Rev 60:184-98. 2008
    ..The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration...
  39. ncbi Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells
    Tapas R Nayak
    Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Singapore 117543
    ACS Nano 5:4670-8. 2011
    ..The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene's potential for stem cell research...
  40. ncbi Mediation of biomaterial-cell interactions by adsorbed proteins: a review
    Cameron J Wilson
    Tissue BioRegeneration Domain, Institute of Health and Biomedical Innovation, School of Engineering Systems, Queensland University of Technology, Brisbane, Queensland, Australia
    Tissue Eng 11:1-18. 2005
    ..Hence, one of the key issues yet to be resolved is that of the interface composition actually encountered by osteoblasts within the sequence of inflammation and bone regeneration...
  41. ncbi Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects
    Yuki Usui
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto Nagano 390 8621, Japan
    Small 4:240-6. 2008
    ..These findings should encourage development of clinical treatment modalities involving CNTs...
  42. ncbi Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs
    K F Leong
    School of Mechanical and Production Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Biomaterials 24:2363-78. 2003
    ..The advantages and limitations of the SFF techniques are compared. Related research carried out worldwide by different institutions, including the authors' research are discussed...
  43. ncbi Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization
    Haiying Yu
    Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
    Biomaterials 30:508-17. 2009
    ..These findings suggest that hybrid grafts have great potential for clinical use to treat large bone defects...
  44. pmc Nanopattern-induced changes in morphology and motility of smooth muscle cells
    Evelyn K F Yim
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Biomaterials 26:5405-13. 2005
    ..It is proposed that this nanoimprinting technology will provide a valuable platform for studies in cell-substrate interactions and for development of medical devices with nanoscale features...
  45. ncbi Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering
    Lie Ma
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
    Biomaterials 24:4833-41. 2003
    ..25% GA-treated scaffold is a long-term process. All these results suggest that collagen/chitosan scaffold cross-linked by GA is a potential candidate for dermal equivalent with enhanced biostability and good biocompatibility...
  46. ncbi Electrospinning of polymeric nanofibers for tissue engineering applications: a review
    Quynh P Pham
    Department of Bioengineering, Rice University, Houston, Texas 77251 1892, USA
    Tissue Eng 12:1197-211. 2006
    ....
  47. ncbi Collagen tissue engineering: development of novel biomaterials and applications
    Lian Cen
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    Pediatr Res 63:492-6. 2008
    ..The field of tissue engineering will ultimately be advanced by increasing control of collagen in native tissue and by continual manipulation of biomaterials...
  48. ncbi Extracellular matrix bioscaffolds for orthopaedic applications. A comparative histologic study
    Jolene E Valentin
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    J Bone Joint Surg Am 88:2673-86. 2006
    ..The purpose of the present study was to evaluate the host-tissue morphologic response to five commercially available extracellular matrix-derived biologic scaffolds used for orthopaedic soft-tissue repair in a rodent model...
  49. ncbi Morphologic study of small intestinal submucosa as a body wall repair device
    Stephen Badylak
    Department of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Surg Res 103:190-202. 2002
    ..Quantitative characterization of the host tissue response to this xenogeneic scaffold material has been lacking...
  50. ncbi Cell type-specific response to growth on soft materials
    Penelope C Georges
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Appl Physiol 98:1547-53. 2005
    ..We will attempt to link the mechanoresponse to real pathological states and speculate on the possible biological significance of mechanosensing...
  51. ncbi Preparation and characterization of cationic PLGA nanospheres as DNA carriers
    M N V Ravi Kumar
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, D 66123, Saarbrucken, Germany
    Biomaterials 25:1771-7. 2004
    ..These cationic PLGA nanospheres could serve as potential alternatives of the existing negatively charged nanoparticles...
  52. ncbi Polyetheretherketone as a biomaterial for spinal applications
    Jeffrey M Toth
    Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Box 26099, Milwaukee, WI 53226 0099, USA
    Biomaterials 27:324-34. 2006
    ..Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer's increased radiolucency and decreased stiffness...
  53. ncbi Extracellular matrix as a biological scaffold material: Structure and function
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Acta Biomater 5:1-13. 2009
    ....
  54. ncbi Advancing dental implant surface technology--from micron- to nanotopography
    Gustavo Mendonça
    Universidade Catolica de Brasilia, Pos Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av W5 Norte 70 790 160 Brasília, DF, Brazil
    Biomaterials 29:3822-35. 2008
    ..Nanoscale modification of titanium endosseous implant surfaces can alter cellular and tissue responses that may benefit osseointegration and dental implant therapy...
  55. ncbi Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes
    Sebastian Bauer
    Department of Materials Science, WW4 LKO, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Acta Biomater 4:1576-82. 2008
    ..Adsorption of extracellular matrix proteins as fibronectin, type I collagen and laminin, as well as bovine serum albumin, on the coated and uncoated surfaces showed a strong influence on wetting behavior and dependence on tube diameter...
  56. ncbi Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2
    Gabriel Colon
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907 2022, USA
    J Biomed Mater Res A 78:595-604. 2006
    ..In this manner, this study suggests that nanophase ZnO and TiO(2) may reduce S. epidermidis adhesion and increase osteoblast functions necessary to promote the efficacy of orthopedic implants...
  57. pmc Biomaterials in orthopaedics
    M Navarro
    Biomaterials, Implants and Tissue Engineering, Institute for Bioengineering of Catalonia IBEC, CIBER BBN, 08028 Barcelona, Spain
    J R Soc Interface 5:1137-58. 2008
    ..In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field...
  58. ncbi Carbon nanotube applications for tissue engineering
    Benjamin S Harrison
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 28:344-53. 2007
    ..Overall, carbon nanotubes may play an integral role as unique biomaterial for creating and monitoring engineered tissue...
  59. ncbi Biomimetism and bioinspiration as tools for the design of innovative materials and systems
    Clement Sanchez
    Laboratoire de Chimie de la Matiere Condensee, Universite Pierre and Marie Curie, Ecole Pratique des Hautes Etudes, Centre National de la Recherche Scientifique, 4 place Jussieu, Tour 54, 5eme etage, 75005 Paris, France
    Nat Mater 4:277-88. 2005
    ..Elucidating the basic components and building principles selected by evolution to propose more reliable, efficient and environment-respecting materials requires a multidisciplinary approach...
  60. ncbi Macro/microporous silk fibroin scaffolds with potential for articular cartilage and meniscus tissue engineering applications
    Le Ping Yan
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Taipas, Guimaraes, Portugal
    Acta Biomater 8:289-301. 2012
    ..Based on these results, the scaffolds developed in this study are proposed to be suitable for use in meniscus and cartilage tissue-engineered scaffolding...
  61. pmc Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Int J Nanomedicine 7:1101-14. 2012
    ..Porous membranes with a CS content of 0.112 ± 0.003 nmol per 10 mg scaffold may hold potential for use in corneal stromal tissue engineering...
  62. ncbi Synthesis, structure and properties of poly(L-lactide-co-ε-caprolactone) statistical copolymers
    Jorge Fernandez
    University of the Basque Country UPV EHU, Department of Mining Metallurgy Engineering and Materials Science, School of Engineering, Alameda de Urquijo s n 48013 Bilbao, Spain
    J Mech Behav Biomed Mater 9:100-12. 2012
    ..In addition, thermogravimetric analysis demonstrated that PLCLs are more stable to thermal degradation than PLLA and they undergo a more complex degradation mechanism than those of the corresponding homopolymers...
  63. pmc In vitro and in vivo evaluations of nano-hydroxyapatite/polyamide 66/glass fibre (n-HA/PA66/GF) as a novel bioactive bone screw
    Bao Su
    Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    PLoS ONE 8:e68342. 2013
    ..As shown by their good cytocompatibility, excellent biomechanical strength and fast formation and ingrowth of new bone, n-HA/PA66/GF screws are thus suitable for orthopaedic clinical applications. ..
  64. ncbi Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissue engineering
    Caixia Xu
    School of Materials Science and Engineering, South China University of Technology, Ministry of Education, Guangzhou, Guangdong 510640, PR China
    Biomaterials 32:1051-8. 2011
    ..The BG-COL-PS scaffolds fulfill the basic requirements of bone tissue engineering scaffold and have the potential to be applied in orthopedic and reconstructive surgery...
  65. ncbi Interfacing live cells with nanocarbon substrates
    Shuchi Agarwal
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457
    Langmuir 26:2244-7. 2010
    ..These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates...
  66. ncbi The interaction of cells and bacteria with surfaces structured at the nanometre scale
    K Anselme
    Institut de Sciences des Materiaux de Mulhouse, CNRS LRC, Universite de Haute Alsace, Mulhouse, France
    Acta Biomater 6:3824-46. 2010
    ....
  67. pmc Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?
    James C Iatridis
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1188, New York, NY 10029 6574, USA
    Spine J 13:243-62. 2013
    ..Degeneration and injuries of the intervertebral disc (IVD) result in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be optimized based on the biomechanical and biological requirements of the IVD...
  68. ncbi Fabrication of novel biomaterials through molecular self-assembly
    Shuguang Zhang
    Center for Biomedical Engineering NE47 379, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 4307, USA
    Nat Biotechnol 21:1171-8. 2003
    ....
  69. ncbi Biomedical applications of collagen
    C H Lee
    Department of Pharmaceutics, College of Pharmacy, The University of Missouri Kansas City, 5005 Rockhill Rd, Katz Bdg 108, Kansas City, MO 64110, USA
    Int J Pharm 221:1-22. 2001
    ..The advantages and disadvantages of each system are also discussed...
  70. ncbi Rheological characterization of hyaluronic acid derivatives as injectable materials toward nucleus pulposus regeneration
    Antonio Gloria
    Institute of Composite and Biomedical Materials, National Research Council, P le Tecchio 80, 80125, Naples, Italy
    J Biomater Appl 26:745-59. 2012
    ..Both HA derivatives showed a 'gel-like' rheological behavior similar to the native NP tissue and this behavior was not altered by injection...
  71. ncbi Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution
    E J Chong
    Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Acta Biomater 3:321-30. 2007
    ....
  72. ncbi In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering
    Linbo Wu
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No 220, Handan Road, Shanghai 200433, China
    Biomaterials 25:5821-30. 2004
    ....
  73. ncbi The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction
    Emil Ruvinov
    Avram and Stella Goldstein Goren Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biomaterials 32:565-78. 2011
    ..It showed a marked therapeutic efficacy at various tissue levels, as well as potential to induce endogenous regeneration of cardiac muscle...
  74. pmc Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells
    Markus D Schofer
    Department of Orthopedics, University Hospital of Marburg, Baldingerstraße, 35043 Marburg, Germany
    J Mater Sci Mater Med 22:1753-62. 2011
    ..Therefore these different strategies can be combined in order to enhance the osteoblast differentiation of hMSC on PLLA based nanofiber scaffold. By doing this, different signal transduction pathways seem to be up regulated...
  75. ncbi Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds
    Jiangning Chen
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China
    Biomaterials 32:4793-805. 2011
    ....
  76. ncbi Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin
    Ung Jin Kim
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:2775-85. 2005
    ..Importantly, this process offers an entirely new window of materials properties when compared with traditional silk fibroin-based materials...
  77. ncbi Carbon nanotubes: biomaterial applications
    Naoto Saito
    Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Matsumoto, Nagano, 390 8621, Japan
    Chem Soc Rev 38:1897-903. 2009
    ..Future perspectives in this rapidly developing field will also be discussed...
  78. pmc The role of engineered tendon matrix in the stemness of tendon stem cells in vitro and the promotion of tendon-like tissue formation in vivo
    Jianying Zhang
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 32:6972-81. 2011
    ..Together, the findings of this study indicate that ETM may be used to effectively expand TSCs in vitro and with TSCs, to enhance repair of injured tendons in vivo...
  79. ncbi Tradeoffs amongst fatigue, wear, and oxidation resistance of cross-linked ultra-high molecular weight polyethylene
    Sara A Atwood
    Department of Mechanical Engineering, University of California, Berkeley, 2121 Etcheverry Hall, Berkeley, CA 94720, USA
    J Mech Behav Biomed Mater 4:1033-45. 2011
    ..The tradeoff we have shown in fatigue, wear, and oxidation performance is critical to the material's long-term success in total joint replacements...
  80. ncbi Biologically responsive polymeric nanoparticles for drug delivery
    Yolonda L Colson
    Division of Thoracic Surgery, Department of Surgery, Brigham and Women s Hospital, Boston MA 02215, USA
    Adv Mater 24:3878-86. 2012
    ....
  81. ncbi Scaffold: a novel carrier for cell and drug delivery
    Tarun Garg
    Department of Pharmaceutics, ISF College of Pharmacy, Moga Punjab, India 09501223252 M
    Crit Rev Ther Drug Carrier Syst 29:1-63. 2012
    ..The present review gives a detailed account of the need for the development of scaffolds along with the materials used and techniques adopted to manufacture scaffolds for tissue engineering and for prolonged drug delivery...
  82. ncbi Potential of nanofiber matrix as tissue-engineering scaffolds
    Zuwei Ma
    Nanoscience and Nanotechnology Initiative, Division of Bioengineering, National University of Singapore, Singapore
    Tissue Eng 11:101-9. 2005
    ..Owing to their high surface area, functionalized polymer nanofibers will find broad applications as drug delivery carriers, biosensors, and molecular filtration membranes in future...
  83. ncbi Fibrin conduit supplemented with human mesenchymal stem cells and immunosuppressive treatment enhances regeneration after peripheral nerve injury
    Aleksandra M McGrath
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Neurosci Lett 516:171-6. 2012
    ..Moreover, addition of cyclosporine A to the conduits with transplanted MSC significantly reduced the ED1 macrophage reaction...
  84. ncbi Bone-implant interface strength and osseointegration: Biodegradable magnesium alloy versus standard titanium control
    Christoph Castellani
    Department of Paediatric and Adolescent Surgery, Medical University of Graz, Austria
    Acta Biomater 7:432-40. 2011
    ..These results suggest that the investigated biodegradable magnesium alloy not only achieves enhanced bone response but also excellent interfacial strength and thus fulfils two critical requirements for bone implant applications...
  85. pmc Nanotechnological strategies for engineering complex tissues
    Tal Dvir
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Nanotechnol 6:13-22. 2011
    ..We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering...
  86. ncbi Biodegradable collagen patch with covalently immobilized VEGF for myocardial repair
    Yasuo Miyagi
    Department of Surgery and Division of Cardiovascular Surgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
    Biomaterials 32:1280-90. 2011
    ..05) than control, and thickness correlated positively with neovascularization (r = 0.67, p = 0.023). Importantly, angiogenesis in VEGF scaffolds contributed to improved cell survival and tissue formation...
  87. ncbi In vitro and in vivo degradability and cytocompatibility of poly(l-lactic acid) scaffold fabricated by a gelatin particle leaching method
    Yihong Gong
    Department of Polymer Science and Engineering, Zhejiang University, Key Laboratory of Macromolecule Synthesis and Functionalization, Ministry of Education, Hangzhou 310027, China
    Acta Biomater 3:531-40. 2007
    ..The regions occupied initially by PLLA scaffold were filled later by collagen type II secreted by the chondrocytes, but with no evident basophilic proteoglycan...
  88. ncbi Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques
    Satoru Kidoaki
    Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka City, Fukuoka 812 8582, Japan
    Biomaterials 26:37-46. 2005
    ....
  89. ncbi Recent developments in ring opening polymerization of lactones for biomedical applications
    Ann Christine Albertsson
    Department of Fibre and Polymer Technology, The Royal Institute of Technology, S 10044 Stockholm, Sweden
    Biomacromolecules 4:1466-86. 2003
    ..The effect of structure on properties and degradation has been discussed. The applications of these polymers in the biomedical field are described in detail...
  90. ncbi Chitosan/poly(epsilon-caprolactone) blend scaffolds for cartilage repair
    Sara C Neves
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Department of Polymer Engineering, University of Minho, Avepark, Zona Industrial da Gandra, S Cláudio do Barco 4806 909, Caldas das Taipas, Guimaraes, Portugal
    Biomaterials 32:1068-79. 2011
    ..In contrast to 100CHT scaffolds, ECM was homogenously deposited on the 75CHT and 50CHT scaffolds. Although mechanical properties of the 50CHT scaffold were better, the 75CHT scaffold facilitated better neo-cartilage formation...
  91. ncbi Gas foamed open porous biodegradable polymeric microspheres
    Taek Kyoung Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Biomaterials 27:152-9. 2006
    ..These porous scaffold microspheres could be potentially utilized for cultivating cells in a suspension manner and for delivering the seeded cells to the tissue defect site in an injectable manner...
  92. ncbi Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle
    C D Hoemann
    Biomedical and Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 13:318-29. 2005
    ..To regenerate damaged cartilage, cell-assisted repair is thus viewed as a promising therapy, despite being limited by the lack of a suitable technique to deliver and retain chondrogenic cells at the defect site...
  93. ncbi Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
    Shahram Ghanaati
    Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Acta Biomater 6:4476-87. 2010
    ..This study demonstrates that variations in the physical properties of a bone substitute material clearly influence the (extent of the) inflammatory reaction and its consequences...
  94. ncbi Chitosan-gelatin scaffolds for tissue engineering: physico-chemical properties and biological response of buffalo embryonic stem cells and transfectant of GFP-buffalo embryonic stem cells
    W W Thein-Han
    Biomaterials and Biomedical Engineering Research Laboratory, Center for Structural and Functional Materials, University of Louisiana at Lafayette, PO Box 44130, Lafayette, LA 70504 4130, USA
    Acta Biomater 5:3453-66. 2009
    ..Chitosan-gelatin scaffolds were cytocompatible with respect to buffalo ES cells. The study underscores for the first time that chitosan-gelatin scaffolds are promising candidates for ES-cell-based tissue engineering...
  95. ncbi In vitro reaction of endothelial cells to polymer demixed nanotopography
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Biomaterials 23:2945-54. 2002
    ..Of the nanotopographies, the 13 nm islands were seen to give the largest response, with highly spread cell morphologies containing well-defined cytoskeleton...
  96. ncbi Microfluidic assisted synthesis of multi-functional polycaprolactone microcapsules: incorporation of CdTe quantum dots, Fe3O4 superparamagnetic nanoparticles and tamoxifen anticancer drugs
    C H Yang
    Dept of Biological Science and Technology, I Shou University, Taiwan
    Lab Chip 9:961-5. 2009
    ..The result showed superparamagnetic and fluorescent properties, and was used as a controlled drug release vehicle. The composite magnetic and fluorescent PCL microcapsules are potential candidates for a smart drug delivery system...
  97. ncbi Tissue engineering: advances in in vitro cartilage generation
    Makarand V Risbud
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Trends Biotechnol 20:351-6. 2002
    ..The ability to manipulate and reconstitute tissue structure and function in vitro has tremendous clinical implications and is likely to have a key role in cell and gene therapies in coming years...
  98. ncbi Axonal regeneration into Schwann cell grafts within resorbable poly(alpha-hydroxyacid) guidance channels in the adult rat spinal cord
    M Oudega
    The Miami Project to Cure Paralysis, School of Medicine, University of Miami, FL 33136, USA
    Biomaterials 22:1125-36. 2001
    ..Future research should explore the use of polymers that better retain the appropriate mechanical, geometrical and permeability properties over time...
  99. ncbi Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds
    Lorenz Meinel
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, E25 330, 45 Carleton Street, Cambridge, Massachusetts 02139, USA
    J Biomed Mater Res A 71:25-34. 2004
    ....
  100. ncbi First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo
    Goki Matsumura
    Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666 Japan
    Circulation 108:1729-34. 2003
    ..Materials commonly used to repair complex cardiac defects lack growth potential and have other unwanted side effects. We designed and tested a bone marrow cell (BMC)-seeded biodegradable scaffold that avoids these problems...
  101. pmc In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions
    Yoon Yeo
    Department of Chemical Engineering and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Surg 245:819-24. 2007
    ....

Research Grants65

  1. New Reactions for Direct, Native Peptide Ligations
    JEFFREY WILLIAM BODE; Fiscal Year: 2010
    ..It will significantly impact the synthesis of complex biomolecules including proteins, glycoproteins, peptidomimetics, and biocompatible materials.
  2. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..This combination produces acids that penetrate and dissolves the tooth surfaces. GIC's are biocompatible materials having low technique sensitivity and release fluoride (F) which creates internal remineralization of a ..
  3. Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve
    Ivan Vesely; Fiscal Year: 2010
    ..fabricate 24 valves with the mating surfaces between the docking station and the leaflet set made from biocompatible materials, such as steel treated with a number of anti-adhesion coatings shown to repel tissue overgrowth in the ..
  4. Rectal Medication Administration Device for Palliative Care
    BRADFORD MACY; Fiscal Year: 2013
    ..The Phase I program will produce an RMAD with a safe retention balloon made of demonstrated biocompatible materials and processes, and will incorporate human factors design philosophy to ensure patient comfort, ease of ..
  5. Wireless Multi-Modal Brain Monitoring
    BRUCE LANNING; Fiscal Year: 2010
    ..Epilepsy Program and Ad-Tech Medical Instruments Corporation will bring their unique expertise in biocompatible materials and sensors, nanoscale electronics, neurosurgery, neuroscience, and manufacturing, marketing and ..
  6. 3-D Computer Modeling for Optimizing Body Image following Breast Reconstruction
    Mia K Markey; Fiscal Year: 2013
    ..physics and parameterized using experimental measurements of the material properties of human tissues and biocompatible materials used in some reconstructive surgeries...
  7. Injectable, biocompatible poly (vinyl alcohol) hydrogels for tissue bulking
    Gavin Braithwaite; Fiscal Year: 2009
    ..The existing principle technology is a novel method that uses existing biocompatible materials to form a hydrogel from an injectable liquid without a chemical reaction thus making the formulation ..
  8. Artificial Cornea Using New Biomaterials
    MAX MAGINNESS; Fiscal Year: 2009
    ..Use of well proven biocompatible materials (silicones) with appropriate optical and mechanical properties for the entire artificial cornea device ..
  9. ADVANCED MICROFABRICATION TECHNOLOGY
    Larry Walker; Fiscal Year: 2012
    ..develop the tools, protocols and facilities needed to produce multielectrode arrays (MEAs) out of known biocompatible materials for eventual use in humans...
  10. Dental Cast Titanium-Ceramic Bonding
    Zhuo Cai; Fiscal Year: 2003
    ..the search for economical alternatives to expensive noble metal alloys, and 2) the increased demand for biocompatible materials. Since titanium offers both low unit cost and biocompatibility, its use in prosthodontics has been ..
  11. Characterizing TiO2 as an Anti-Inflammatory Biomaterial
    John Frangos; Fiscal Year: 2005
    ..Our long-term goal is to extend this knowledge to develop new biocompatible materials with superior mechanical and material properties than titanium.
  12. The Exploration of New Bio-Relevant Materials Using Surface-Initiated ROMP of Low
    Wei Chen; Fiscal Year: 2007
    ..Of the few existing biocompatible materials, poly(ethylene glycol) (PEG) and phosphorylcholine-containing molecules are the most well-recognized and ..
  13. NEW BIOPOLYMERS FOR MEDICAL APPLICATIONS
    Simon Williams; Fiscal Year: 1993
    ..Specifically, in the biomedical area these novel biocompatible materials may be useful in applications such as: surgical aids as anti-adhesion agents; controlled drug delivery ..
  14. Graphene-FeCo Nanocrystals for Highly Sensitive MRI, Cancer Imaging and Therapy
    Hongjie Dai; Fiscal Year: 2009
    ..Innovations of the application include new nanotechnology approach to biocompatible materials with advanced properties and new grapheme functionalization methods for dense and branched PEGylation and ..
  15. NOVEL DEVICE FOR FABRICATION OF ARTIFICIAL MEMBRANES
    FATEMEH MOJTABAI; Fiscal Year: 1990
    ..useful diagnostics technology for a variety of biomedical applications such as: studying cell-cell recognition events, direct binding assays, fabrication of biocompatible materials, affinity chromatography and bio-specific sensors.
  16. PROTEIN BEHAVIOR AT SILICONE--A SINGLE MOLECULE STUDY
    Viola Vogel; Fiscal Year: 2002
    ..abstract_text> ..
  17. PROTEIN BEHAVIOR AT SILICONE--A SINGLE MOLECULE STUDY
    Viola Vogel; Fiscal Year: 2001
    ..abstract_text> ..
  18. Stereoselective Polymerization of Vinylethers
    ADRIEN LAVOIE; Fiscal Year: 2002
    ..could lead to fantastic new opportunities in the fields of tissue engineering and the development of biocompatible materials. This proposal outlines three general novel strategies aimed toward the stereospecific polymerization of ..
  19. Non-Covalent Modification of Collagen Scaffolds
    Michael Yu; Fiscal Year: 2006
    ..abstract_text> ..
  20. MICRORIBBON CABLE FOR IMPLANTABLE MICROELECTRONICS
    Brian Farrell; Fiscal Year: 2000
    ..ribbon cables and discrete connectors with an integrated rigid flex circuit made out of a class of biocompatible materials known as liquid crystal polymers (LCP) with a unique combination of properties...
  21. Actuable Scaffolds for Smooth Muscle Engineering
    Brian Cox; Fiscal Year: 2007
    ..The long-term objective of this exploratory project is to develop actuable scaffold structures using biocompatible materials, which, under remotely generated magnetic fields, can undergo controlled deformation...
  22. Microribbon Cable/Connector for Implantable Electronics
    Brian Farrell; Fiscal Year: 2003
    ..ribbon cables and discrete connectors with an integrated rigid flex circuit made out of a class of biocompatible materials known as liquid crystal polymers (LCP) with a unique combination of properties...
  23. BIODEGRADABLE HYDROPHILIC POLYACETALS
    MIKHAIL PAPISOV; Fiscal Year: 2001
    ..In this study, we utilize a novel, "biomimetic" approach to developing biocompatible materials. The underlying mechanistic hypothesis of this work suggests that minimally bioreactive biodegradable ..
  24. CHRONIC TRANSCRANIAL ELECTRICAL CONNECTOR
    BRIAN HATT; Fiscal Year: 2000
    ..Phase II will make minor design changes to the package and convert the metal flanges and braze to biocompatible materials such as titanium and gold braze...
  25. New Materials for Tissue Engineering and Drug Delivery
    TARA MEYER; Fiscal Year: 2003
    ..3) To synthesize biocompatible materials with mechanical and biodegradable properties that make them suitable use as components of microchip-based ..
  26. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  27. Chondrogenesis in Enzymatically Degradable Hydrogels
    JASON BURDICK; Fiscal Year: 2008
    ..analyze critical issues of the photopolymerized constructs necessary for clinical application of these techniques. ..
  28. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  29. Correcting dysregulated peripheral tolerance in NOD mice
    Ronald Gill; Fiscal Year: 2004
    ..abstract_text> ..
  30. GENERATING OF ALLOREACTIVE CD4+T TRANSGENIC MICE
    Ronald Gill; Fiscal Year: 2002
    ..They would allow critical evaluation of the hypothesis that: Both islet allograft immunity and tolerance are dependent on CD4 T cells that recognize graft antigen through indirect host MHC-restricted antigen presentation. ..
  31. Sequential Release of Growth Factors for Bone Formation
    Jonathan Leach; Fiscal Year: 2004
    ..Vascularization and bone formation will be compared to several control groups. ..
  32. ROBUST PROTEIN FROM MUSSEL BYSSUS
    JOHN WAITE; Fiscal Year: 2003
    ..The outcome of these should be of particular relevance to the design of scaffolding biomaterials with a wide range of mechanical properties. ..
  33. MICROCHIP DRUG DELIVERY SYSTEM
    Robert Langer; Fiscal Year: 2003
    ..abstract_text> ..
  34. Modulation of T Cell Function by Patterning of Costimulatory Ligands
    Lance Kam; Fiscal Year: 2008
    ..Successful completion of these studies will lead to a better understanding of immune system function and can lead to improved devices and methods for tailoring immune responses. [unreadable] [unreadable] [unreadable]..
  35. Vascularization of engineered cardiac tissue
    Robert Langer; Fiscal Year: 2008
    ..The vascularized constructs will be implanted and examined for integration with the host vasculature. We hypothesize that the vessel network created in vitro will promote the vascularization of the tissue in vivo. ..
  36. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..Based on in vivo animal data criteria will be studied. Based on in vivo animal data criteria will be established for the design of an oral hCT and CKI delivery system for the treatment of postmenopausal osteoporosis. ..
  37. LIPOPROTEINS MODULATE THE HEPATIC RESPONSE TO ENDOTOXIN
    Hobart Harris; Fiscal Year: 2008
    ..abstract_text> ..
  38. ANGIOGENESIS INHIBITORS FROM SHARK CARTILAGE
    Robert Langer; Fiscal Year: 2003
    ..After screening in the in vitro assays mentioned above, potential anti-angiogenic activity from shark cartilage will be assayed in vivo using the chick chonoallantoic assay and the rabbit corneal pocket assay. ..
  39. Single-Molecule Immunoassay and DNA Screening
    Edward Yeung; Fiscal Year: 2005
    ..The first two goals will be the focus of the R21 Phase and the last two goals will be the focus of the R33 Phase of this application. ..
  40. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..The concept of double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drugs for the treatment of ovarian cancer. ..
  41. SURFACE INFLUENCES ON CELL SIGNALING AND PROLIFERATION
    David Grainger; Fiscal Year: 2002
    ....
  42. INTRACELLULAR TRAFFICKING OF TROPOELASTIN
    Frederick Grinnell; Fiscal Year: 2002
    ....
  43. MOLECULAR BASIS OF HEPATIC HYPERMETABOLISM IN BURNS
    Martin Yarmush; Fiscal Year: 2001
    ..abstract_text> ..
  44. PH SENSITIVE COMPLEX HYDROGEL FOR PROTEIN DRUG RELEASE
    NIKOLAOS PEPPAS; Fiscal Year: 2001
    ..Finally, the insulin delivery efficacy of these novel devices will be tested using in vivo experiments. ..
  45. CONTROLLED RELEASE OF MACROMOLECULES
    Robert Langer; Fiscal Year: 2001
    ..The long-term objectives of this research are to develop robust DNA stabilization methods to meet the pharmaceutical requirements for controlled release gene delivery systems. ..
  46. EPITHELIALIZATION OF TISSUE ENGINEERED CORNEAS
    JEAN JACOB; Fiscal Year: 2003
    ..The results of these studies will provide insight into the processes involved in the success or failure of corneal augmentation and replacement by artificial implants. ..
  47. TARGETING TO LYMPHOCYTES MEDIATED BY SYNTHETIC EPITOPES
    Jindrich Kopecek; Fiscal Year: 2004
    ..The results of the proposed studies will provide a new method to treat human lymphomas. ..
  48. Biomimetic Blades: Mincing with Less Mineral
    JOHN WAITE; Fiscal Year: 2005
    ..The chief health benefits of this research will be insights about lightweight replacement materials with superior hardness and abrasion resistance. ..
  49. Nanomachines for RNA Synthesis and DNA Repair (RMI)
    Gang Bao; Fiscal Year: 2004
    ..The detailed plan for the GNC will be developed from results of this workshop and also through further preliminary studies that couple nanotechnology tools and models with the selected biological phenomena. ..
  50. Nanostructured, Liquid Crystalline Dental Restoratives
    Scott Schricker; Fiscal Year: 2004
    ..Conventional evaluations for clinical performance such as flexural strength, compressive strength, shrinkage and wear will be performed. This application represents a new methodology in the design of dental restoratives. ..
  51. Mussel-Inspired Protective Coatings
    JOHN WAITE; Fiscal Year: 2006
    ..All films will be evaluated by macro- and nanomechanical tests, and their resistance to a diverse range of biochemical, thermal, and mechanical insults will be examined. ..
  52. HEPATIC TISSUE ENGINEERING
    Martin Yarmush; Fiscal Year: 2006
    ..The proposed studies will also provide basic tools useful in the development of other engineered tissues and organs. ..
  53. Real Time Functional Genomics of Metabolism/Cell Arrays
    Martin Yarmush; Fiscal Year: 2004
    ..In summary, the proposed work seeks to provide fundamental research and a base of personnel equipped to solve problems in fields such as metabolic engineering where complex biological phenomena are under investigation. ..
  54. Neuronal Biointerface: Micropatterned Lipid Bilayers
    Lance Kam; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  55. Cardioprotective Repair through Cardiopoiesis
    Andre Terzic; Fiscal Year: 2010
    ..abstract_text> ..
  56. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  57. Conference Support: The 13th International Drug Delivery Symposium
    David Grainger; Fiscal Year: 2007
    ..Support is requested both for selected speaker participation costs and 3 junior scientist poster travel awards. [unreadable] [unreadable] [unreadable]..
  58. CONTROLLED RELEASE OF MACROMOLECULES
    Robert Langer; Fiscal Year: 2007
    ..Our best performing polymer-DNA formulations, identified in aims one and two, wilt be assayed in vivo in mice for 1) delivery efficiency, 2) specificity and biodistribution, and 3) complement activation and initial safety profile. ..
  59. Capillary Electrophoresis Profiling of Tears in Dry Eye
    JEAN JACOB; Fiscal Year: 2006
    ....
  60. AVS Biomaterials Interface Division Technical Program Support
    David Grainger; Fiscal Year: 2006
    ..A number of relevant leading scientists and engineers from companies working in these technology areas are also recruited to participate using the new "Commercial Challenge" podium opportunity. [unreadable] [unreadable] [unreadable]..
  61. In vivo gene detection for cancer analysis
    Gang Bao; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  62. Training in Stem Cell Research
    Martin Yarmush; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  63. Improved Measurements of Vocal Fold-Related Tissues
    Sarah Klemuk; Fiscal Year: 2006
    ..Surface roughness of plate and substrate surfaces will be quantified using SEM technology and Scanning Probe Microscopy. [unreadable] [unreadable]..
  64. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..An attempt will be made to elucidate the mechanism of contraction blocking during healing of injured nerves, and to find out an association, if any, with induced regeneration. ..
  65. LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICES
    Ioannis Yannas; Fiscal Year: 2002
    ..These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration. ..