pheromones

Summary

Summary: Chemical substances, excreted by an organism into the environment, that elicit behavioral or physiological responses from other organisms of the same species. Perception of these chemical signals may be olfactory or by contact.

Top Publications

  1. ncbi Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons
    Pingxi Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75335, USA
    Neuron 45:193-200. 2005
  2. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
  3. ncbi Soluble proteins in insect chemical communication
    P Pelosi
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa Italy, Agrarie via S Michele, 4, 56124, Pisa, Italy
    Cell Mol Life Sci 63:1658-76. 2006
  4. pmc Signal transduction cascades regulating fungal development and virulence
    K B Lengeler
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Microbiol Mol Biol Rev 64:746-85. 2000
  5. ncbi Sensing odorants and pheromones with chemosensory receptors
    Kazushige Touhara
    Department of Integrated Biosciences, The University of Tokyo, Chiba, 277 8562 Japan
    Annu Rev Physiol 71:307-32. 2009
  6. pmc Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development
    Jennifer C Chang
    Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 7:e1002190. 2011
  7. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
  8. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
  9. pmc Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
    Liming Wang
    Division of Biology 216 76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 463:227-31. 2010
  10. ncbi The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
    Sachiko Haga
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Nature 466:118-22. 2010

Research Grants

  1. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
  2. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
  3. Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory N
    Albert Folch; Fiscal Year: 2012
  4. TERPENE CONDENSATION REACTIONS
    CHARLES POULTER; Fiscal Year: 2009
  5. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
  6. Genes Influencing Social Behaviors
    DONALD WELLS PFAFF; Fiscal Year: 2010
  7. TERPENE CONDENSATION REACTIONS
    CHARLES DALE POULTER; Fiscal Year: 2013
  8. Transduction mechanisms and CNS targets of GC-D neurons
    Steven D Munger; Fiscal Year: 2013
  9. GENETIC ANALYSIS OF OLFACTION
    Dean P Smith; Fiscal Year: 2013
  10. Cell-cell signaling, gene expression, and horizontal gene transfer in Bacillus
    Alan D Grossman; Fiscal Year: 2013

Detail Information

Publications312 found, 100 shown here

  1. ncbi Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons
    Pingxi Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75335, USA
    Neuron 45:193-200. 2005
    ..These studies directly link pheromone-induced behavior with OBP-dependent activation of a subset of olfactory neurons...
  2. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
    Insects, like many other animals, use sex pheromones to coordinate their reproductive behaviours. Volatile pheromones are detected by odorant receptors expressed in olfactory receptor neurons (ORNs)...
  3. ncbi Soluble proteins in insect chemical communication
    P Pelosi
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa Italy, Agrarie via S Michele, 4, 56124, Pisa, Italy
    Cell Mol Life Sci 63:1658-76. 2006
    ..Finally, we discuss current ideas and models of the role of such proteins in insect chemoreception...
  4. pmc Signal transduction cascades regulating fungal development and virulence
    K B Lengeler
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Microbiol Mol Biol Rev 64:746-85. 2000
    ..cerevisiae can serve as a paradigm for signaling in other organisms and also how studies in other fungi provide insights into conserved signaling pathways that operate in many divergent organisms...
  5. ncbi Sensing odorants and pheromones with chemosensory receptors
    Kazushige Touhara
    Department of Integrated Biosciences, The University of Tokyo, Chiba, 277 8562 Japan
    Annu Rev Physiol 71:307-32. 2009
    ..molecules derived from food or the environment that signal the presence of food, fire, or predators, and (b) pheromones, molecules released from individuals of the same species that convey social or sexual cues...
  6. pmc Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development
    Jennifer C Chang
    Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 7:e1002190. 2011
    ..We found that Rgg2 and Rgg3 together tightly regulate two linked genes encoding new peptide pheromones. Rgg2 activates transcription of and is required for full induction of the pheromone genes, while Rgg3 plays an ..
  7. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ..that SNMP is required for responses of OR67d to cVA when ectopically expressed in OSNs not normally activated by pheromones. Because mammalian CD36 binds fatty acids, we suggest that SNMP acts in concert with odorant receptors to ..
  8. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
    Mice use pheromones, compounds emitted and detected by members of the same species, as cues to regulate social behaviours such as pup suckling, aggression and mating...
  9. pmc Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
    Liming Wang
    Division of Biology 216 76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 463:227-31. 2010
    Aggression is regulated by pheromones in many animal species. However, in no system have aggression pheromones, their cognate receptors and corresponding sensory neurons been identified...
  10. ncbi The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor
    Sachiko Haga
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Nature 466:118-22. 2010
    Various social behaviours in mice are regulated by chemical signals called pheromones that act through the vomeronasal system...
  11. ncbi Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
    ..Therefore, the pheromone-binding protein is an inactive, extracellular ligand converted by pheromone molecules into an activator of pheromone-sensitive neurons and reveals a distinct paradigm for detection of odorants...
  12. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
    ..We propose a model describing how these receptors might be used by a male to distinguish suitable from unsuitable mating partners through a simple logic...
  13. pmc A receptor and binding protein interplay in the detection of a distinct pheromone component in the silkmoth Antheraea polyphemus
    Maike Forstner
    University of Hohenheim, Institute of Physiology, Stuttgart, Germany
    Int J Biol Sci 5:745-57. 2009
    Male moths respond to conspecific female-released pheromones with remarkable sensitivity and specificity, due to highly specialized chemosensory neurons in their antennae...
  14. ncbi Optimal traffic organization in ants under crowded conditions
    Audrey Dussutour
    Centre de Recherches sur la Cognition Animale, UMR CNRS 5169, Universite Paul Sabatier, 118 route de Narbonne, F 31062 Toulouse Cedex 4, France
    Nature 428:70-3. 2004
    ..The balancing mechanism between cohesive and dispersive forces appears to be generic in natural, urban and transportation systems...
  15. pmc Homothallic and heterothallic mating in the opportunistic pathogen Candida albicans
    Kevin Alby
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Nature 460:890-3. 2009
    ..C. albicans Deltabar1 a cells were shown to secrete both a and alpha mating pheromones; alpha-pheromone activated self-mating in these cells in a process dependent on Ste2, the receptor for alpha-..
  16. pmc Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range
    Ty M Thomson
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:20265-70. 2011
    ..Additional analysis and experiment suggest that scaffold abundance sets a tradeoff between maximum system output and system dynamic range, a prediction supported by recent experiments...
  17. ncbi Insect pheromones--an overview of biosynthesis and endocrine regulation
    J A Tillman
    Department of Biochemistry 330, University of Nevada, Reno 89557 0014, USA
    Insect Biochem Mol Biol 29:481-514. 1999
    ..Coleopteran sex and aggregation pheromones also arise from modifications of fatty acid biosynthesis or other biosynthetic pathways, such as the isoprenoid ..
  18. pmc Fungal mating pheromones: choreographing the dating game
    Stephen K Jones
    Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, United States
    Fungal Genet Biol 48:668-76. 2011
    b>Pheromones are ubiquitous from bacteria to mammals - a testament to their importance in regulating inter-cellular communication...
  19. ncbi Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
    Fuqiang Xu
    Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA
    J Comp Neurol 489:491-500. 2005
    ..that the main olfactory system processes common odors and the accessory olfactory system is specifically for pheromones. The potential for these two systems to respond simultaneously to the same stimuli has not been fully explored ..
  20. ncbi From pheromones to behavior
    Roberto Tirindelli
    Department of Neuroscience, University of Parma, Parma and International School for Advanced Studies, Scuola Internazionale Superiore di Studi Avanzati and Italian Institute of Technology, SISSA Unit, Trieste 34014, Italy
    Physiol Rev 89:921-56. 2009
    In recent years, considerable progress has been achieved in the comprehension of the profound effects of pheromones on reproductive physiology and behavior...
  21. ncbi Cuticular hydrocarbons: their evolution and roles in Drosophila pheromonal communication
    Jean François Ferveur
    Unité de Recherche 5548 Associée au Centre National de la Recherche Scientifique, Faculte des Sciences, Universite de Bourgogne, 6 Bd Gabriel, 21000, Dijon, France
    Behav Genet 35:279-95. 2005
    ....
  22. ncbi Sexual reproduction between partners of the same mating type in Cryptococcus neoformans
    Xiaorong Lin
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 434:1017-21. 2005
    ....
  23. pmc Hierarchical chemosensory regulation of male-male social interactions in Drosophila
    Liming Wang
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:757-62. 2011
    b>Pheromones regulate male social behaviors in Drosophila, but the identities and behavioral role(s) of these chemosensory signals, and how they interact, are incompletely understood...
  24. pmc Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes
    Patrick T McGrath
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, New York 10065, USA
    Nature 477:321-5. 2011
    ..Chemical communication through pheromones that accumulate during high-density growth causes young nematode larvae to enter the long-lived but non-..
  25. ncbi Candidate pheromone receptors provide the basis for the response of distinct antennal neurons to pheromonal compounds
    Ewald Grosse-Wilde
    University of Hohenheim, Institute of Physiology 230, Garbenstrasse 30, 70599 Stuttgart, Germany
    Eur J Neurosci 25:2364-73. 2007
    ..The data provide further evidence that a combination of a distinct receptor type and binding protein underlie the specific response observed in the detection of a pheromone component in vivo...
  26. pmc An Expressed Sequence Tag collection from the male antennae of the Noctuid moth Spodoptera littoralis: a resource for olfactory and pheromone detection research
    Fabrice Legeai
    1IRISA, Equipe Symbiose, Campus Universitaire de Beaulieu, 35042 Rennes Cedex, France
    BMC Genomics 12:86. 2011
    ..Here, we describe an Expressed Sequence Tag (EST) project to characterize the antennal transcriptome of the noctuid pest model, Spodoptera littoralis, and to identify candidate genes involved in odour/pheromone detection...
  27. pmc Sensation in a single neuron pair represses male behavior in hermaphrodites
    Jamie Q White
    Department of Biology and Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 0840, USA
    Neuron 75:593-600. 2012
    b>Pheromones elicit innate sex-specific mating behaviors in many species. We demonstrate that in C. elegans, male-specific sexual attraction behavior is programmed in both sexes but repressed in hermaphrodites...
  28. ncbi Cdc42 explores the cell periphery for mate selection in fission yeast
    Felipe O Bendezú
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland
    Curr Biol 23:42-7. 2013
    ..Thus, Cdc42 exploration serves to orient growth for partner selection. This process may also promote genetic diversification...
  29. ncbi The role of multiple pheromones in food recruitment by ants
    A Dussutour
    School of Biological Sciences and Centre for Mathematical Biology, The University of Sydney, Sydney, NSW 2006, Australia
    J Exp Biol 212:2337-48. 2009
    ..We further investigate experimentally the role of these pheromones under both static and dynamic conditions and develop a mathematical model based on the hypothesis that ..
  30. pmc Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system
    Takao Nakagawa
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065, USA
    Curr Opin Neurobiol 19:284-92. 2009
    ..Here we consider all the evidence and offer a consensus model for a noncanonical mechanism of olfactory signal transduction in insects...
  31. ncbi A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila
    Tal Soo Ha
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:8727-33. 2006
    Insect pheromones elicit stereotypic behaviors that are critical for survival and reproduction...
  32. pmc Generalization of courtship learning in Drosophila is mediated by cis-vaccenyl acetate
    Aki Ejima
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS008, Waltham, MA 02454, USA
    Curr Biol 17:599-605. 2007
    ..These findings suggest that transfer of cVA to females during mating may be part of the male's strategy to suppress reproduction by competing males...
  33. pmc Drosophila cuticular hydrocarbons revisited: mating status alters cuticular profiles
    Claude Everaerts
    Centre des Sciences du Gout et de l Alimentation, UMR 6265 CNRS, UMR 1324 INRA, Universite de Bourgogne, Agrosup, Dijon, France
    PLoS ONE 5:e9607. 2010
    Most living organisms use pheromones for inter-individual communication...
  34. ncbi Small-molecule pheromones that control dauer development in Caenorhabditis elegans
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Chem Biol 3:420-2. 2007
    ..The identification of dauer pheromone components 1 and 2 will facilitate the identification of target receptors and downstream signaling proteins...
  35. ncbi Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway
    Albrecht Gruhler
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Campusvej 55, DK 5230 Odense M, Denmark
    Mol Cell Proteomics 4:310-27. 2005
    ....
  36. ncbi Functional and expression pattern analysis of chemosensory proteins expressed in antennae and pheromonal gland of Mamestra brassicae
    E Jacquin-Joly
    INRA, Unité de Phytopharmacie et des Médiateurs Chimiques, Bat A, Route de Saint Cyr, F 78026 Versailles Cedex, France
    Chem Senses 26:833-44. 2001
    ..This suggests that the M. brassicae CSP could be involved in transport of hydrophobic molecules through different aqueous media, such as the sensillar lymph, as well as the pheromonal gland cytosol...
  37. ncbi The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
    Roby P Bhattacharyya
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Science 311:822-6. 2006
    ..Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-output properties...
  38. ncbi Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone
    Pan Young Jeong
    Department of Biochemistry and Yonsei Proteome Research Center, Seoul 120 749, Korea
    Nature 433:541-5. 2005
    b>Pheromones are cell type-specific signals used for communication between individuals of the same species...
  39. ncbi Pheromone communication in the honeybee (Apis mellifera L.)
    Keith N Slessor
    Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
    J Chem Ecol 31:2731-45. 2005
    ..Here, we discuss this rapidly evolving field for honeybees, the only social insect for which any primer pheromones have been identified...
  40. pmc Pheromone anosmia in a scarab beetle induced by in vivo inhibition of a pheromone-degrading enzyme
    Martine Maïbèche-Coisne
    Maeda Duffey Lab, Department of Entomology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11459-64. 2004
    ..diversa, which became insensitive to physiological concentrations of pheromones for a few minutes...
  41. ncbi Interactions of insect pheromones and plant semiochemicals
    Gadi V P Reddy
    Agricultural Experiment Station, College of Natural and Applied Sciences, University of Guam, Mangilao, Guam 96923, USA
    Trends Plant Sci 9:253-61. 2004
  42. pmc SNMP is a signaling component required for pheromone sensitivity in Drosophila
    Xin Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 105:10996-1001. 2008
    ..Therefore, pheromone perception in Drosophila should serve as an excellent model to elucidate the role of CD36 members in transmembrane signaling...
  43. ncbi 'Infotaxis' as a strategy for searching without gradients
    Massimo Vergassola
    CNRS URA 2171, Institut Pasteur, In Silico Genetics, 75724 Paris Cedex 15, France
    Nature 445:406-9. 2007
    ..The proposed search algorithm is relevant to the design of olfactory robots, but the general idea of infotaxis can be applied more broadly in the context of searching with sparse information...
  44. ncbi Mammary odor cues and pheromones: mammalian infant-directed communication about maternal state, mammae, and milk
    Benoist Schaal
    Research Group in Developmental Ethology and Cognitive Psychology, Center for Taste and Smell Science, CNRS, Dijon, France
    Vitam Horm 83:83-136. 2010
    ..But the ways by which these chemical cues are produced and assembled on the mammae are both diverse between species and complex within species, offering an outstanding opportunity for comparative analyses in chemical communication...
  45. pmc The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs
    Fabio Papes
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 141:692-703. 2010
    ..ligands belonging to the major urinary protein (Mup) family, homologs of aggression-promoting mouse pheromones. We show that recombinant Mup proteins are sufficient to activate sensory neurons and initiate defensive ..
  46. ncbi Specialized cells tag sexual and species identity in Drosophila melanogaster
    Jean Christophe Billeter
    Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada
    Nature 461:987-91. 2009
    ..7,11-HD), showing that female aphrodisiac compounds can attenuate the effects of male aversive pheromones. 7,11-HD also was shown to have a crucial role in heterospecific encounters...
  47. pmc Biosynthesis of the Caenorhabditis elegans dauer pheromone
    Rebecca A Butcher
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:1875-9. 2009
    ..Thus, daf-22 and dhs-28 are required for the biosynthesis of the short-chain fatty acid-derived side chains of the dauer pheromone and link dauer pheromone production to metabolic state...
  48. ncbi Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans
    Kyuhyung Kim
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Science 326:994-8. 2009
    Intraspecific chemical communication is mediated by signals called pheromones. Caenorhabditis elegans secretes a mixture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate dauer larval stage ..
  49. ncbi Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects
    R G Vogt
    Yale University School of Medicine, Section of Molecular Neurobiology, New Haven, Connecticut 06510
    J Neurobiol 22:74-84. 1991
    ..The association of different insect OBP subfamilies with distinct classes of olfactory neurons having different odorant specificities suggests that OBPs can act as selective signal filters, peripheral to the actual receptor proteins...
  50. ncbi Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
    M Kleerebezem
    Department of Biophysical Chemistry, NIZO, Ede, The Netherlands
    Mol Microbiol 24:895-904. 1997
    ..Moreover, genetic linkage of the common elements involved results in autoregulation of peptide-pheromone production...
  51. ncbi Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci
    B Fleuchot
    INRA, UMR1319 MICALIS, F 78352 Jouy en Josas, France
    Mol Microbiol 80:1102-19. 2011
    ....
  52. ncbi Social context influences chemical communication in D. melanogaster males
    Clement Kent
    Department of Biology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada
    Curr Biol 18:1384-9. 2008
    ..An exchange of cues that resembles a dialogue between males and females is enacted by pheromones, chemical signals that pass between individual flies to alter physiology and behavior...
  53. pmc Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target
    Søren Kjaerulff
    Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, DK 1353 Copenhagen K, Denmark
    Mol Cell Biol 25:2045-59. 2005
    ....
  54. ncbi Scent wars: the chemobiology of competitive signalling in mice
    Jane L Hurst
    Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston CH64 7TE
    Bioessays 26:1288-98. 2004
    ....
  55. pmc The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
    S M O'Rourke
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 0448, USA
    Genes Dev 12:2874-86. 1998
    ..Finally, we have found that pseudohyphal growth exhibited by wild-type (HOG1) strains depends on SHO1, suggesting that Sho1p may be a receptor that feeds into the pseudohyphal growth pathway...
  56. ncbi Molecular detection of pheromone signals in mammals: from genes to behaviour
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 4:551-62. 2003
  57. pmc Brain response to putative pheromones in lesbian women
    Hans Berglund
    Department of Medicine, and Stockholm Brain Institute, Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8269-74. 2006
    ..AND) and the estrogen-like steroid estra-1,3,5(10),16-tetraen-3-ol (EST) are candidate compounds for human pheromones. In previous positron emission tomography studies, we found that smelling AND and EST activated regions ..
  58. ncbi The secret codes of mammalian scents
    David M Ferrero
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Wiley Interdiscip Rev Syst Biol Med 2:23-33. 2010
    ..Among these social odors are pheromones, chemicals that trigger innate behaviors and physiological responses...
  59. pmc Role of the Enterococcus faecalis GelE protease in determination of cellular chain length, supernatant pheromone levels, and degradation of fibrin and misfolded surface proteins
    Christopher M Waters
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 185:3613-23. 2003
    ..These new functions attributed to GelE suggest that it acts to increase the dissemination of E. faecalis in high-density environments...
  60. pmc Identification and characterization of a Candida albicans mating pheromone
    Richard J Bennett
    Department of Microbiology and Immunology, University of California San Francisco, 600 16th Street, Suite N372, San Francisco, CA 94143, USA
    Mol Cell Biol 23:8189-201. 2003
    ..albicans in a mouse model of disseminated candidiasis. This observation suggests that aspects of cell-cell communication in mating may have been evolutionarily adopted for host-pathogen interactions in C. albicans...
  61. ncbi Perception of odor blending mixtures in the newborn rabbit
    Gérard Coureaud
    Centre Européen des Sciences du Goût, Equipe d Ethologie et de Psychobiologie Sensorielle, UMR 5170 CNRS UB INRA, Dijon 21000, France
    Physiol Behav 95:194-9. 2008
    ..4). Therefore, both elemental and configural processing of the mixture seem to be displayed by rabbit pups, suggesting that neonatal perception of a simple odor mixture may involve more than the perception of its constituents...
  62. ncbi Ligand-interaction kinetics of the pheromone- binding protein from the gypsy moth, L. dispar: insights into the mechanism of binding and release
    Yongmei Gong
    Department of Chemistry, Simon Fraser University, Burnaby, BC V5A1S6, Canada
    Chem Biol 16:162-72. 2009
    ..This experimentally derived model sheds light on the potential biological function and mechanism of PBPs as ligand scavengers...
  63. ncbi The 'male effect' in sheep and goats--revisiting the dogmas
    J Alberto Delgadillo
    Centro de Investigación en Reproducción Caprina, Universidad Autonoma Agraria Antonio Narro, Periférico Raúl López Sánchez y Carretera a Santa Fe, Coahuila, Mexico
    Behav Brain Res 200:304-14. 2009
    ..We can now ask new questions regarding the application of the male effect in industry and develop research so we can fully understand this biological phenomenon...
  64. ncbi Semiochemicals used in host location by the coffee berry borer, Hypothenemus hampei
    Esayas Mendesil
    Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    J Chem Ecol 35:944-50. 2009
    ..Attraction to the synthetic blend was comparable to that for the natural sample. The significance of the study is discussed in terms of semiochemical based pest management methods of the coffee berry borer...
  65. ncbi Sxa2 is a serine carboxypeptidase that degrades extracellular P-factor in the fission yeast Schizosaccharomyces pombe
    G Ladds
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Mol Microbiol 36:377-90. 2000
    Stimulating the fission yeast Schizosaccharomyces pombe with mating pheromones brings about responses that lead to cell conjugation...
  66. ncbi Genetic analysis of brain circuits underlying pheromone signaling
    C Dulac
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Genet 40:449-67. 2006
    ..We will review and discuss the specific contribution of each of the two chemosensory systems that ensure specific behavioral responses to conspecific animals...
  67. ncbi Angiosperm bark volatiles disrupt response of Douglas-fir beetle, Dendroctonus pseudotsugae, to attractant-baited traps
    D P Huber
    Centre for Environmental Biology, Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6
    J Chem Ecol 27:217-33. 2001
    ..Nonhost angiosperm bark volatiles may have practical utility on their own or in combination with the antiaggregation pheromone 3-methylcyclohex-3-en-1-one (MCH) to protect single trees, logs, or stands from attack by the DFB...
  68. pmc Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport
    H Liu
    Section of Biochemistry, Cornell University, Ithaca, New York 14853
    J Cell Biol 118:285-99. 1992
    ..We conclude that tropomyosin, and by inference actin cables, may facilitate directed vesicular transport of components to the correct location on the cell surface...
  69. ncbi Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements
    T Aono
    Department of Biology, Faculty of Science, Osaka City University, Japan
    Yeast 10:757-70. 1994
    ..Point mutations in the TR-box motif abolished the expression of mat1-Pm/lacZ. Almost no expression of mat1-Pm was detected in a ste11 deletion mutant, whereas overproduction of Ste11 greatly increased the expression...
  70. pmc MAP kinase pathways in the yeast Saccharomyces cerevisiae
    M C Gustin
    Department of Biochemistry and Cell Biology Rice University, Houston, Texas 77251 1892, USA
    Microbiol Mol Biol Rev 62:1264-300. 1998
    ..This review is therefore an attempt to present the current knowledge of MAPK pathways in yeast and some directions for future research in this area...
  71. ncbi Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins
    Graham Ladds
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Mol Microbiol 47:781-92. 2003
    ..This is the first time that human GPCRs have been coupled to the signalling pathway in Sz. pombe, and the strains described in this study will complement the other systems available for studying this important family of receptors...
  72. pmc Analysis of Cryptococcus neoformans sexual development reveals rewiring of the pheromone-response network by a change in transcription factor identity
    Emilia K Kruzel
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 191:435-49. 2012
    ..gene regulatory components during eukaryotic evolution...
  73. ncbi Manipulation of parasitoids for aphid pest management: progress and prospects
    Wilf Powell
    IACR Rothamsted, Harpenden, Hertfordshire AL5 2JQ, UK
    Pest Manag Sci 59:149-55. 2003
    ..Female parasitoids respond both to aphid sex pheromones acting as kairomones, and to aphid-induced plant volatiles, acting as synomones...
  74. pmc Cdc42p and Fus2p act together late in yeast cell fusion
    Casey A Ydenberg
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:1208-18. 2012
    ..Thus, in addition to signaling and morphogenetic roles in mating, Cdc42p plays a role late in cell fusion via activation of Fus2p...
  75. pmc Positive roles for negative regulators in the mating response of yeast
    John R Houser
    Department of Physics, University of North Carolina, Chapel Hill, NC 27599 7260, USA
    Mol Syst Biol 8:586. 2012
    ..This mechanism allows the transcriptional response to act on a shorter time scale than upstream pathway activity...
  76. ncbi Attraction of Drosophila melanogaster males to food-related and fly odours
    Sebastien Lebreton
    Swedish University of Agricultural Sciences, Department of Plant Protection Biology, Chemical Ecology Group, Alnarp, Sweden
    J Insect Physiol 58:125-9. 2012
    ..Our findings demonstrate the essential role of food odours and pheromones for mate location in D. melanogaster.
  77. pmc Roles for receptors, pheromones, G proteins, and mating type genes during sexual reproduction in Neurospora crassa
    Hyojeong Kim
    Department of Plant Pathology and Microbiology, Program in Biochemistry and Molecular Biology, University of California, Riverside, California 92521, USA
    Genetics 190:1389-404. 2012
    ..between the PRE-2 pheromone receptor and its ligand, CCG-4, and the general requirements for receptors, pheromones, G proteins, and mating type genes during fusion of opposite mating-type cells and sexual sporulation in the ..
  78. ncbi The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe
    G Ladds
    School of Biochemistry, University of Birmingham, UK
    Mol Microbiol 20:35-42. 1996
    ..occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a ..
  79. pmc Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast
    Rita Gelin-Licht
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Cell Rep 1:483-94. 2012
    ..This is, to our knowledge, the first demonstration of ligand-activated RNA targeting in the development of a simple eukaryote...
  80. ncbi Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography
    Z Bocskei
    Department of Biochemistry and Molecular Biology, University of Leeds, UK
    Nature 360:186-8. 1992
    ..sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine...
  81. ncbi Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila
    Weiwei Liu
    Beijing Normal University College of Life Sciences, Beijing, China
    Nat Neurosci 14:896-902. 2011
    ....
  82. pmc Genetics of a pheromonal difference affecting sexual isolation between Drosophila mauritiana and D. sechellia
    J A Coyne
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genetics 145:1015-30. 1997
    ....
  83. pmc Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway
    P M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester Foundation Campus, Shrewsbury, Massachusetts 01545, USA
    Genes Dev 12:2684-97. 1998
    ..Moreover, our results suggest that this event promotes kinase cascade activation by delivering the Ste5-associated kinases to the cell surface kinase Ste20, whose function may depend on Cdc42 and Cdc24...
  84. ncbi Molecular mechanisms underlying the mitosis-meiosis decision
    Yuriko Harigaya
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Chromosome Res 15:523-37. 2007
    ....
  85. ncbi Why does Candida albicans switch?
    David R Soll
    Department of Biology, The University of Iowa, Iowa City, IA 52242, USA
    FEMS Yeast Res 9:973-89. 2009
    ..The discovery that mating-competent opaque cells signaled mating-incompetent white cells, through the release of pheromones, to become adhesive and form biofilms provided a clue to this fundamental question...
  86. pmc A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila
    Thomas Chertemps
    Universite Pierre et Marie Curie, UMR, Physiologie de l Insecte, Signalisation et Communication, Paris, France
    BMC Biol 10:56. 2012
    ..As Est-6 is also known to hydrolyze cVA in vitro and is expressed in the main olfactory organ, the antenna, we tested here its role in olfaction as a putative odorant-degrading enzyme...
  87. ncbi Causes and consequences of variability in peptide mating pheromones of ascomycete fungi
    Simon H Martin
    Department of Genetics, Forestry and Agricultural Biotechnology Institute, University of Pretoria, South Africa
    Mol Biol Evol 28:1987-2003. 2011
    ..Ascomycetes produce two classes of mating type-specific peptide pheromones. These are required for recognition between the mating types of heterothallic species...
  88. pmc Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24
    Z S Zhao
    Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
    Mol Cell Biol 15:5246-57. 1995
    ..The two-hybrid system revealed that Ste4p interacts with Cdc24p. We propose that Cdc42p plays a pivotal role both in polarization of the cytoskeleton and in pheromone signalling...
  89. ncbi Courtship, aggression and avoidance: pheromones, receptors and neurons for social behaviors in Drosophila
    Anupama Dahanukar
    Department of Entomology, University of California, Riverside, CA, USA
    Fly (Austin) 5:58-63. 2011
    ..seen important advances in the identification of chemoreceptors and sensory neurons that are involved in sensing pheromones. Here we present a brief review of the current understanding of the peripheral chemosensory systems that are ..
  90. pmc In search of the chemical basis for MHC odourtypes
    Jae Kwak
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Proc Biol Sci 277:2417-25. 2010
    ..Furthermore, there is a need to consider a 'combinatorial odour recognition' code whereby patterns of volatile metabolites (the basis for odours) specify MHC odourtypes...
  91. pmc Self-organized lane formation and optimized traffic flow in army ants
    I D Couzin
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Biol Sci 270:139-46. 2003
    ..The model explores the influences of turning rates and local perception on traffic flow. The behaviour of real army ants is such that they occupy the specific region of parameter space in which lanes form and traffic flow is maximized...
  92. ncbi Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast
    Takaharu G Yamamoto
    Cell Biology Group and CREST Research Project, Kansai Advanced Research Center, National Institute of Information and Communication Technology, 588 2 Iwaoka cho, Iwaoka, Nishi ku, Kobe 651 2492, Japan
    J Cell Sci 117:3875-86. 2004
    ..In contrast, in meiosis induced by inactivation of Pat1, sister chromatids segregate precociously during the first meiotic division. Thus, these results suggest that activation of Spk1 drives meiosis in S. pombe...
  93. ncbi Path efficiency of ant foraging trails in an artificial network
    Karla Vittori
    Department of Electrical Engineering, University of Sao Paulo, Av Trabalhador Saocarlense, 400 Centro 13566 590, Sao Carlos, SP, Brazil
    J Theor Biol 239:507-15. 2006
    ..A sensitivity study of the model suggests that the bias observed in the choice of the ants at asymmetrical bifurcations is a key behavior to reproduce the collective choice observed in the experiments...
  94. ncbi Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae
    G Xu
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Mol Microbiol 20:773-83. 1996
    ..These data show that a new component, Ste50p, determines the extent and the duration of signal transduction by acting between the G protein and the MAP kinase complex in S. cerevisiae...
  95. pmc Identification of bacteria and bacteria-associated chemical cues that mediate oviposition site preferences by Aedes aegypti
    Loganathan Ponnusamy
    Department of Entomology and W M Keck Center for Behavioral Biology, Box 7613, North Carolina State University, Raleigh, NC 27695 7613, USA
    Proc Natl Acad Sci U S A 105:9262-7. 2008
    ..aegypti, and the kairomones will likely enhance the efficacy of surveillance and control programs for this disease vector of substantial global public health importance...
  96. ncbi Male axillary extracts contain pheromones that affect pulsatile secretion of luteinizing hormone and mood in women recipients
    George Preti
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 68:2107-13. 2003
    ..These effects are thought to arise from exposure to primer pheromones that are produced in the underarm...
  97. pmc Basidiomycete mating type genes and pheromone signaling
    Marjatta Raudaskoski
    Friedrich Schiller University, Institute of Microbiology, Microbial Phytopathology, Neugasse 25, Jena, Germany
    Eukaryot Cell 9:847-59. 2010
    ..Additionally, the pheromone-dependent signaling through monomeric, small GTPases potentially involved in creating the polarized cytoskeleton for reciprocal nuclear exchange and migration during mating is predicted...
  98. pmc Scent marking behavior as an odorant communication in mice
    Hiroyuki Arakawa
    Pacific Bioscience Research Center, University of Hawaii at Manoa, 1993 East West Road, Honolulu, HI 96822, USA
    Neurosci Biobehav Rev 32:1236-48. 2008
    ....
  99. ncbi Discrimination of alarm pheromone (E)-beta-farnesene by aphid odorant-binding proteins
    Huili Qiao
    Department of Agricultural Chemistry and Biotechnologies, University of Pisa via S Michele, Italy
    Insect Biochem Mol Biol 39:414-9. 2009
    ..We suggest that OBP3 could mediate response of aphids to the alarm pheromone...
  100. pmc Opaque cells signal white cells to form biofilms in Candida albicans
    Karla J Daniels
    Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
    EMBO J 25:2240-52. 2006
    ..These results reveal a novel form of communication between switch phenotypes, analogous to the inductive events during embryogenesis in higher eukaryotes...
  101. ncbi Representation of primary plant odorants in the antennal lobe of the moth Heliothis virescens using calcium imaging
    H T Skiri
    Norwegian University of Science and Technology, Department of Biology, Neuroscience Unit, Olav Kyrres gate 3, NO 7489 Trondheim, Norway
    Chem Senses 29:253-67. 2004
    ..Stronger activation in the AL due to increased odour concentration was expressed as increased response strength within the odorant-specific glomeruli as well as recruitment of less sensitive glomeruli...

Research Grants63

  1. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
    ..pathways through which such signals access reproductive circuits has impeded our understanding of how human "pheromones" may affect behavior...
  2. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..Traditionally, the vomeronasal epithelium was thought to detect pheromones - chemicals released by a conspecific that elicit a physiological or behavioral response in the recipient - ..
  3. Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory N
    Albert Folch; Fiscal Year: 2012
    ..the dynamics and the specificity of the responses of OSNs to a large variety of odorants, complex odors, and pheromones. Pheromones are volatile organic compounds that elicit or modulate innate behaviors such as mating, rearing of ..
  4. TERPENE CONDENSATION REACTIONS
    CHARLES POULTER; Fiscal Year: 2009
    ..in membranes, as lipophilic moieties that anchor cofactors and proteins to membranes, in vision, as mating pheromones, and as defensive agents, to name a few...
  5. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pheromones stimulate some olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE), but the transduction mechanism is poorly understood...
  6. Genes Influencing Social Behaviors
    DONALD WELLS PFAFF; Fiscal Year: 2010
    ..nuclei are involved in fear;the central nucleus in anxiety;and the mediocortical region in signaling by pheromones. All of these functions could influence the three behaviors measured in this project...
  7. TERPENE CONDENSATION REACTIONS
    CHARLES DALE POULTER; Fiscal Year: 2013
    ..in membranes, as lipophilic moieties that anchor cofactors and proteins to membranes, in vision, as mating pheromones, and as defensive agents, to name a few...
  8. Transduction mechanisms and CNS targets of GC-D neurons
    Steven D Munger; Fiscal Year: 2013
    ..For example, semiochemicals (chemosensory stimuli that communicate information between organisms;e.g., pheromones or social cues) can promote mating or aggression behaviors or can contribute to transmission of food preferences ..
  9. GENETIC ANALYSIS OF OLFACTION
    Dean P Smith; Fiscal Year: 2013
    ..Many insect behaviors, including mating, are triggered by perception of pheromones. Understanding how pheromones are detected at the molecular level will provide new targets to manipulate ..
  10. Cell-cell signaling, gene expression, and horizontal gene transfer in Bacillus
    Alan D Grossman; Fiscal Year: 2013
    ..Signaling processes are often mediated by diffusible factors (e.g., hormones, pheromones, neurotransmitters) that are produced by some cells and sensed by others...
  11. From Pheromone Receptors to Social Behaviors
    HUBERT O AMREIN; Fiscal Year: 2012
    ..As a general strategy, we will utilize Drosophila melanogaster as a model system to elucidate the roles of pheromones and their receptors in social behaviors, such as courtship, mating, aggression etc...
  12. Phenotypic Plasticity and Inter-Species Communication in Candida Albicans
    STEPHEN KNOX JONES; Fiscal Year: 2013
    ..albicans strains I have constructed that secrete pheromones native to these other species in place of its own...
  13. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2013
    ..Aim 2 focuses on the functions of MAT, including roles of pheromones and Ste3 receptor homologs in virulence via processes similar to quorum sensing...
  14. TRP Channels, From Sensory Signaling to Human Disease
    Craig Montell; Fiscal Year: 2009
    ..tastants, mechanical stimuli, and environmental chemicals, changes in temperature and in some animals, light and pheromones. Defects in TRP channels underlie many diseases, including the childhood neurodegenerative disorder, MLIV...
  15. Oral streptococcal-enterococcal peptide-mediated intercellular communication
    M Margaret Vickerman; Fiscal Year: 2012
    ..E. faecalis secretes multiple hepta- and octameric peptide pheromones that induce a mating response in enterococci harboring specific families of conjugative plasmids...
  16. Genetic Mapping of Functional Vomeronasal Circuits
    CONGRONG RON YU; Fiscal Year: 2013
    ..These behaviors are robust and stereotyped, but their expression critically depends on the proper response to pheromones. The vomeronasal circuit connects directly to the endocrine systems and influences their output...
  17. REGULATION OF CAMP TRANSIENTS IN NEURONS
    Daniel R Storm; Fiscal Year: 2013
    ..provided by applicant): Mammals have the capacity to discriminate between an immense variety of odorants and pheromones. Pheromones are airborne chemical signals that are released by an individual into that affect the physiology and ..
  18. Pheromone Signaling, Sex, and Virulence in Candida albicans
    RICHARD JOHN BENNETT; Fiscal Year: 2013
    ..Preliminary experiments suggest that sexual pheromones act to reduce the cellular integrity of responding cells...
  19. Sensory processing of social and defensive chemosignals
    Catherine G Dulac; Fiscal Year: 2013
    ..in many species, the signals essential for guiding social interactions rely on the emission and detection of pheromones. Rodents strongly rely on the vomeronasal system to detect these cues and guide genetically pre-programmed ..
  20. First Transcriptome to the Tick Olfactory System
    RICHARD MICHAEL ROE; Fiscal Year: 2012
    ..Dr. Sonenshine, a co-PI on this proposal, has also conducted much of the pioneering work on tick pheromones and their role in adult reproduction in Dv...
  21. Mechanisms of pheromone signal transduction in C. elegans
    DANNA MINDY ZEIGER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pheromones act as both short-term olfactory cues that signal danger or the presence of mates, as well as long-term cues, which mediate changes in development and physiology via modulation of the ..
  22. Identification of the ligands and sensory neurons that mediate pheromone behavior
    LISA T STOWERS; Fiscal Year: 2013
    ..to chemically tag, enrich, and profile small molecules of any physicochemical class to identify the specific pheromones that encode a single defined behavior...
  23. Neural Mechanisms of Olfactory Pattern Recognition
    Timothy E Holy; Fiscal Year: 2013
    ..The accessory olfactory system (AOS) is at least partially specialized to detect cues, often called pheromones, which regulate social behavior among members of the same species...
  24. Molecular genetics of contact chemosensation
    Craig Montell; Fiscal Year: 2013
    ..Contact chemosensation allows flies to distinguish sweet from bitter molecules, as well as nonvolatile pheromones. Insect gustatory organs express a diversity of candidate molecular detectors...
  25. Pheromones and Titan Cell Production in Cryptococcus neoformans
    Kirsten Nielsen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pheromones and pheromone receptors have long been known to affect virulence of the opportunistic pathogen Cryptococcus neoformans, yet it is still entirely unclear how the biological ramifications of ..
  26. The Ninth International Congress of Neuroethology Proposal
    George D Pollak; Fiscal Year: 2010
    ..networks for olfactory behavior, acoustic communication, molecular evolution of vision, behaviors guided by pheromones, among others...
  27. Molecular mechanisms and genetic architecture of sexual attractiveness.
    DANIEL EDWARD PROMISLOW; Fiscal Year: 2013
    ..establish that: (i) both aging and the insulin signaling pathway modulate the production of specific chemical pheromones in Drosophila (a.ka...
  28. Intraspecific chemosignals in the main olfactory system
    Weihong Lin; Fiscal Year: 2012
    ..Potential channel M5 (TRPM5), is present in a subset of mouse mature OSNs involved in olfactory signaling of pheromones and urinary components...
  29. YEAST PHEROMONE SIGNAL TRANSDUCTION
    Peter M Pryciak; Fiscal Year: 2013
    ..Response to mating pheromones in yeast involves the dynamic assembly of plasma membrane-localized signaling complexes, which include proteins ..
  30. GABAergic Involvement in Caenorhabditis elegans Social Behavior
    JOSHUA SOLOMON GREENE; Fiscal Year: 2013
    ..We found roaming and dwelling is also influenced by C. elegans density pheromones called ascarosides...
  31. Neural circuits mediating food, pherome, and repulsive odor behaviors
    CHRISTOPHER JOHN POTTER; Fiscal Year: 2013
    ..cortex (lateral horn) is divided into two broad domains, one representing food odors and one representing pheromones. Therefore, this olfactory region, which to the naked eye looks homogenous, might be organized into olfactory ..
  32. The Molecular Basis of Pheromone-induced Behaviors in Drosophila
    Dean P Smith; Fiscal Year: 2013
    ..Volatile pheromones trigger or modulate social behaviors including mating...
  33. Genetic control of a sexually dimorphic neural circuit
    KELLI A FAGAN; Fiscal Year: 2013
    ..To this end, we are studying a sexually dimorphic response to ascaroside sex pheromones in C. elegans. Ascarosides elicit attraction in males but not in hermaphrodites...
  34. Mechanistic Dissection of Pheromone-Dependent Regulation of Group A Streptococcal
    Michael J Federle; Fiscal Year: 2013
    ..Our preliminary results demonstrate that Rgg paralogs found in GAS are indeed responsive to small peptide pheromones, providing a convincing precedent for our hypothesis and are the first examples that Rgg proteins are quorum ..
  35. Molecular Characterization of Insect Pheromone Chemosensory Mutants in Nematodes
    Ray L Hong; Fiscal Year: 2012
    ..elegans, but may be more closely modeled by the arthropod associated P. pacificus that senses insect host pheromones. This proposal outlines the first olfaction behavioral screen in P...
  36. Gustatory Coding in Drosophila Legs
    FREDERICK LING; Fiscal Year: 2011
    ..In addition, the legs have also been suggested to detect pheromones and to play key roles in mating behavior...
  37. Dynamics and Bifurcations of Population Structures Induced by Cell Cycle Feedback
    ERIK MIKLOS BOCZKO; Fiscal Year: 2012
    ..when cells in one part of the cell cycle (G0,G1,S,G2,M) communicate with cells in another via metabolites and/or pheromones, with the consequence that the later population experiences advances and/or delays in their growth rate...
  38. Ligand selectivity of vomeronasal receptors
    Hiroaki Matsunami; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Vomeronasal receptors are thought to play an important role in detecting pheromones, although it is unclear which receptors are activated by which pheromones...
  39. 2nd ASM Conference on Cell-Cell Communication
    Bonnie Bassler; Fiscal Year: 2004
    Only a few years ago, the exchange of chemical signals, or pheromones, between bacteria was considered the exception rather than the rule...
  40. Parasite/Host Interactions and the Neurobiology of Fear
    Robert Sapolsky; Fiscal Year: 2006
    ..parasite blunts the innate aversion of rats for the urine of cats, producing instead an attraction towards cat pheromones. This appears to be a rather specific effect (rather than merely being secondary to damage to the olfactory ..
  41. Analysis of Circuitry in the Accessory Olfactory Bulb System
    Ken Hovis; Fiscal Year: 2009
    ..with its simple circuitry and direct effect on the behavioral, hormonal and metabolic state associated with pheromones. In addition, it provides us with a simple system in which to study the organization and integration of input ..
  42. PHEROMONES, BEHAVIOR AND THE REGULATION OF FERTILITY
    Martha McClintock; Fiscal Year: 2001
    ..Among rats, the social signals that regulate the timing of the ovarian cycle are pheromones from different phases of the ovarian cycle. These pheromones can either advance or delay ovulation...
  43. Peptide Pheromones in Enterococcal Plasmid Maintenance
    BETTINA BUTTARO; Fiscal Year: 2006
    ..abstract_text> ..
  44. G PROTEINS AND SIGNAL TRANSDUCTION IN NEUROSPORA CRASSA
    KATHERINE BORKOVICH; Fiscal Year: 2006
    ..b>Pheromones, cAMP and other molecules will be tested as ligands...
  45. Comparative Behavioral Metabolomics in Nematodes
    Arthur S Edison; Fiscal Year: 2012
    ..elegans pheromones. In the activity-guided identification, worm conditioned water will be fractionated and bioassayed for both ..
  46. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 2005
    ..On the other, it mediates the detection of pheromones, chemicals released from animals that stimulate neuroendocrine alterations and stereotyped behaviors in members ..
  47. A link between mating pheromone sensing and virulence of Cryptococcus neoformans
    Kirsten Nielsen; Fiscal Year: 2009
    ..Because C. neoformans cells sense and respond to cells of the opposite mating partner using pheromones, in preliminary experiments we disrupted pheromone sensing in both a and a cells and discovered that a cells are ..
  48. ASM Conference on Cell-Cell Communication in Bacteria
    STEPHEN WINANS; Fiscal Year: 2001
    Only a few years ago, the exchange of chemical signals, or pheromones, between bacteria was considered the exception rather than the rule...
  49. NEURAL INTEGRATION AND LUTEINIZING HORMONE SECRETION
    ARTHUR COQUELIN; Fiscal Year: 1990
    ..For example, species specific odors (pheromones) disseminated by females are detected by the vomer nasal system and enhance luteinizing hormone (LH) and ..
  50. BIOCHEMICAL ANALYSIS OF THE YEAST A-FACTOR RECEPTOR
    GEORGE SPRAGUE; Fiscal Year: 1991
    Interaction between peptide pheromones and cell surface receptors controls cell division and other physiological events during mating in the yeast Saccharomyces cerevisiae...
  51. SEX PHEROMONE INDUCED PLASMID TRANSFER
    DON CLEWELL; Fiscal Year: 2002
    ..Conjugative plasmids encoding a mating response to peptide sex pheromones are ubiquitous in E...
  52. PHEROMONE REGULATION OF MATURATION IN A MODEL SYSTEM
    Gene Robinson; Fiscal Year: 1999
    ..Primer pheromones that inhibit endocrine-mediated behavioral development will be identified; few such primer pheromones, from any ..
  53. MAINTENANCE OF ENTEROCOCCUS FAECALIS PLASMID PAD1
    KEITH WEAVER; Fiscal Year: 1992
    ..These plasmids respond to specific peptide sex pheromones produced by potential recipients by directing the synthesis of an adhesive substance which facilitates the ..
  54. CHARACTERIZATION OF SEXUAL PHEROMONES IN APLYSIA
    SHERRY PAINTER; Fiscal Year: 1993
    ..These studies will demonstrate whether the atrial gland is a physiological source of sexual pheromones, and whether the pheromonal factors are products of the ELH-related genes expressed in the atrial gland...
  55. IDENTIFICATION OF PHEROMONES REGULATING REPRODUCTION
    Alan Singer; Fiscal Year: 1991
    ..nature of compounds that regulate reproduction in mammals via chemosensory mechanisms, with an emphasis on pheromones that are detected by non-olfactory nasal chemoreceptors...
  56. PHEROMONES, BEHAVIOR AND THE REGULATION OF FERTILITY
    Martha McClintock; Fiscal Year: 1990
    ..These odors are pheromones and may result in the synchronization or suppression of estrus within the social group, two different strategies ..
  57. MOLECULAR STUDIES OF A MAMMALIAN PHEROMONE
    L Rasmussen; Fiscal Year: 2000
    ..from the Investigator's Abstract): This research aims to delineate the molecular mechanisms through which sexual pheromones initiate chemosignalling and thereby influence physiology and behavior...
  58. Ascaroside signaling and aging in Caenorhabditis elegans
    FRANK CLEMENS SCHROEDER; Fiscal Year: 2010
    ..have recently been shown to induce development arrest (dauer formation) and, furthermore to act as sex pheromones. Our preliminary results show that ascarosides not only act as dauer or mating signals, but also strongly ..
  59. OLFACTORY CONTROL OF A SIMPLE MOTOR SYSTEM
    JOHN HILDEBRAND; Fiscal Year: 1992
    ..For example, the sex pheromones released by a receptive female trigger a characteristic flight response in a male, by which he orients and moves ..
  60. ENCODING OF BIOLOGICALLY RELEVANT ODOR SIGNALS
    John Caprio; Fiscal Year: 2005
    ..and goldfishes because these are the only vertebrates for which both feeding- related odorants and sex-signaling pheromones are chemically well- defined...
  61. 3RD INTERNATIONAL CONFERENCE ON STREPTOCOCCAL GENETICS
    Gary Dunny; Fiscal Year: 1990
    ..studies have progressed, they have revealed the presence of unique biological phenomena such as bacterial sex pheromones and conjugative transposons...
  62. SEXUAL DIFFERENTIATION OF MOUSE VOMERONASAL FUNCTION
    James Cherry; Fiscal Year: 2004
    The vomeronasal organ (VNO) projection pathway mediates many of the effects of pheromones on essential psychosexual and neuroendocrine functions in a variety of vertebrate species...
  63. NEW CATALYSTS FOR ASYMMETRIC DIELS-ALDER REACTIONS
    Peter Mackenzie; Fiscal Year: 1991
    ..is therefore frequently essential in the synthesis of a number of important pharmaceuticals, food additives and pheromones. Catalytic asymmetric DielsAlder reactions represent an almost uniquely attractive means of achieving such ..