misoprostol

Summary

Summary: A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.

Top Publications

  1. pmc Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial
    N Mobeen
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan Gynuity Health Projects, New York, NY, USA
    BJOG 118:353-61. 2011
  2. ncbi Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial
    Richard J Derman
    University of Missouri Kansas City School of Medicine, MO, USA
    Lancet 368:1248-53. 2006
  3. pmc Misoprostol for postpartum hemorrhage prevention at home birth: an integrative review of global implementation experience to date
    Jeffrey Michael Smith
    JHPIEGO, 1776 Massachusetts Ave, NW 300, Washington, DC 20036, USA
    BMC Pregnancy Childbirth 13:44. 2013
  4. ncbi Comparison of misoprostol and manual vacuum aspiration for the treatment of incomplete abortion
    C Bique
    José Macamo Hospital, Maputo, Mozambique
    Int J Gynaecol Obstet 98:222-6. 2007
  5. pmc Rethinking WHO guidance: review of evidence for misoprostol use in the prevention of postpartum haemorrhage
    Christina S Chu
    School of Social and Political Science, University of Edinburgh, Edinburgh EH8 9LD, UK
    J R Soc Med 105:336-47. 2012
  6. ncbi Introducing misoprostol for the treatment of incomplete abortion in Nigeria
    Talemoh Dah
    Ipas, Chapel Hill, NC 27516, USA
    Afr J Reprod Health 15:42-50. 2011
  7. ncbi Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects
    O S Tang
    Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong SAR, China
    Int J Gynaecol Obstet 99:S160-7. 2007
  8. ncbi Is misoprostol a safe, effective and acceptable alternative to manual vacuum aspiration for postabortion care? Results from a randomised trial in Burkina Faso, West Africa
    B Dao
    Centre Hospitalier National Souro Sanou, Bobo Dioulasso, Burkina Faso
    BJOG 114:1368-75. 2007
  9. ncbi Misoprostol use in developing countries: results from a multicountry study
    J Sherris
    PATH, Seattle, WA, USA
    Int J Gynaecol Obstet 88:76-81. 2005
  10. ncbi Community-based distribution of misoprostol for treatment or prevention of postpartum hemorrhage: cost-effectiveness, mortality, and morbidity reduction analysis
    Tori Sutherland
    Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, USA
    Int J Gynaecol Obstet 108:289-94. 2010

Detail Information

Publications310 found, 100 shown here

  1. pmc Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial
    N Mobeen
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan Gynuity Health Projects, New York, NY, USA
    BJOG 118:353-61. 2011
    to determine if misoprostol is safe and efficacious in preventing postpartum haemorrhage (PPH) when administered by trained traditional birth attendants (TBA) at home deliveries.
  2. ncbi Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial
    Richard J Derman
    University of Missouri Kansas City School of Medicine, MO, USA
    Lancet 368:1248-53. 2006
    ..We aimed to investigate whether oral misoprostol, a potential alternative to oxytocin, could prevent postpartum haemorrhage in a community home-birth setting.
  3. pmc Misoprostol for postpartum hemorrhage prevention at home birth: an integrative review of global implementation experience to date
    Jeffrey Michael Smith
    JHPIEGO, 1776 Massachusetts Ave, NW 300, Washington, DC 20036, USA
    BMC Pregnancy Childbirth 13:44. 2013
    ..guidelines for the prevention and management of postpartum hemorrhage (PPH) recommend oral administration of misoprostol by community health workers (CHWs)...
  4. ncbi Comparison of misoprostol and manual vacuum aspiration for the treatment of incomplete abortion
    C Bique
    José Macamo Hospital, Maputo, Mozambique
    Int J Gynaecol Obstet 98:222-6. 2007
    To compare the safety, efficacy, and acceptability of misoprostol versus manual vacuum aspiration (MVA) for treatment of incomplete abortion in Maputo, Mozambique.
  5. pmc Rethinking WHO guidance: review of evidence for misoprostol use in the prevention of postpartum haemorrhage
    Christina S Chu
    School of Social and Political Science, University of Edinburgh, Edinburgh EH8 9LD, UK
    J R Soc Med 105:336-47. 2012
    This article describes and critically appraises clinical trials assessing misoprostol effectiveness in preventing primary postpartum haemorrhage (PPH) in home and community settings in low- and middle-income countries...
  6. ncbi Introducing misoprostol for the treatment of incomplete abortion in Nigeria
    Talemoh Dah
    Ipas, Chapel Hill, NC 27516, USA
    Afr J Reprod Health 15:42-50. 2011
    Despite legal restriction, induced abortions and resulting complications are common in Nigeria. Misoprostol administration for incomplete abortion was introduced in 3 Nigerian hospitals...
  7. ncbi Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects
    O S Tang
    Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong SAR, China
    Int J Gynaecol Obstet 99:S160-7. 2007
    b>Misoprostol, a synthetic prostaglandin E1 analogue, is commonly used for medical abortion, cervical priming, the management of miscarriage, induction of labor and the management of postpartum hemorrhage...
  8. ncbi Is misoprostol a safe, effective and acceptable alternative to manual vacuum aspiration for postabortion care? Results from a randomised trial in Burkina Faso, West Africa
    B Dao
    Centre Hospitalier National Souro Sanou, Bobo Dioulasso, Burkina Faso
    BJOG 114:1368-75. 2007
    Previous research has demonstrated the effectiveness of misoprostol for treatment of incomplete abortion; however, few studies have systematically compared misoprostol's effectiveness with that of standard surgical care...
  9. ncbi Misoprostol use in developing countries: results from a multicountry study
    J Sherris
    PATH, Seattle, WA, USA
    Int J Gynaecol Obstet 88:76-81. 2005
    To identify information and service delivery needs for obstetric/gynecologic uses of misoprostol in developing countries.
  10. ncbi Community-based distribution of misoprostol for treatment or prevention of postpartum hemorrhage: cost-effectiveness, mortality, and morbidity reduction analysis
    Tori Sutherland
    Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, USA
    Int J Gynaecol Obstet 108:289-94. 2010
    To compare the cost-effectiveness of community-based distribution of misoprostol for prevention with misoprostol for treatment of postpartum hemorrhage (PPH).
  11. pmc Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: a systematic review
    Thoai D Ngo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, England, UK
    Bull World Health Organ 89:360-70. 2011
    ..To compare medical abortion practised at home and in clinics in terms of effectiveness, safety and acceptability...
  12. pmc Where there are (few) skilled birth attendants
    Ndola Prata
    Bixby Center for Population, Health and Sustainability, University of California Berkeley, 229 University Hall, Berkeley, CA 94720 6390, USA
    J Health Popul Nutr 29:81-91. 2011
    ..Training community-based birth attendants in primary and secondary prevention technologies (e.g. misoprostol, family planning, measurement of blood loss, and postpartum care) will increase the chance that women in the ..
  13. ncbi A randomized trial of misoprostol compared with manual vacuum aspiration for incomplete abortion
    Andrew Weeks
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women s Hospital, Liverpool, England, UK
    Obstet Gynecol 106:540-7. 2005
    To compare the safety, efficacy, and acceptability of misoprostol and manual vacuum aspiration for the treatment of incomplete abortion in a hospital setting in Kampala, Uganda.
  14. pmc Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health centre in Guinea-Bissau: randomised double blind clinical trial
    Lars Høj
    Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus N, Denmark
    BMJ 331:723. 2005
    To evaluate whether routine administration of sublingual misoprostol 600 microg after delivery reduces postpartum haemorrhage.
  15. ncbi Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole
    David Y Graham
    Veterans Affairs Medical Center 111D, 2002 Holcombe Blvd, Room 3A 320, Houston, TX 77030 4211, USA
    Arch Intern Med 162:169-75. 2002
    ....
  16. ncbi Estimation of potential effects of improved community-based drug provision, to augment health-facility strengthening, on maternal mortality due to post-partum haemorrhage and sepsis in sub-Saharan Africa: an equity-effectiveness model
    Christina Pagel
    Clinical Operational Research Unit, Department of Mathematics, University College London, London, UK
    Lancet 374:1441-8. 2009
    ....
  17. ncbi Prevention of postpartum hemorrhage: options for home births in rural Ethiopia
    N Prata
    Bixby Center for Population, Health and Sustainability, University of California, Berkeley, School o Public Health, 229 University Hall, Berkeley, CA 94720, USA
    Afr J Reprod Health 13:87-95. 2009
    ..sought to determine the safety and feasibility of home-based prophylaxis of postpartum hemorrhage (PPH) with misoprostol, including assessment of the need for referrals and additional interventions...
  18. ncbi Expectant, medical or surgical treatment for spontaneous abortion in first trimester of pregnancy: a cost analysis
    Joyce H S You
    Centre for Pharmacoeconomics Research, School of Pharmacy, Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT
    Hum Reprod 20:2873-8. 2005
    b>Misoprostol and expectant care have been shown to be acceptable alternatives to routine surgical evacuation for treatment of spontaneous abortion in the first trimester of pregnancy...
  19. ncbi A randomized controlled trial comparing medical and expectant management of first trimester miscarriage
    J S Bagratee
    Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal, Durban, South
    Hum Reprod 19:266-71. 2004
    We aimed to determine whether outpatient treatment of miscarriage with vaginal misoprostol is more effective than expectant management in reducing the need for surgical evacuation of retained products of conception (ERPC).
  20. ncbi Vaginal misoprostol prior to insertion of an intrauterine device: an RCT
    Kirsten Dijkhuizen
    Department of Gynaecology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Reprod 26:323-9. 2011
    b>Misoprostol is an agent that may ripen the cervix in nonpregnant women...
  21. ncbi Expanding uterotonic protection following childbirth through community-based distribution of misoprostol: operations research study in Nepal
    Swaraj Rajbhandari
    Options Cambodia
    Int J Gynaecol Obstet 108:282-8. 2010
    To determine feasibility of community-based distribution of misoprostol for preventing postpartum hemorrhage (PPH) to pregnant woman through community volunteers working under government health services.
  22. ncbi Sublingual misoprostol versus intramuscular oxytocin for prevention of postpartum hemorrhage in low-risk women
    Picklu Chaudhuri
    Department of Obstetrics and Gynecology, Chittaranjan Sevasadan College of Obstetrics and Gynecology and Child Health, Kolkata, India
    Int J Gynaecol Obstet 116:138-42. 2012
    To compare sublingual misoprostol with intramuscular oxytocin for prevention of postpartum hemorrhage (PPH) in low-risk vaginal birth.
  23. ncbi Training traditional birth attendants to use misoprostol and an absorbent delivery mat in home births
    Ndola Prata
    Bixby Center for Population, Health and Sustainability, School of Public Health, University of California at Berkeley, 17 University Hall, UC Berkeley, Berkeley, CA 94720 7360, USA
    Soc Sci Med 75:2021-7. 2012
    ..In the absence of skilled birth attendants, training TBAs in the use of misoprostol and an absorbent delivery mat to measure postpartum blood loss may strengthen the ability of TBAs to manage PPH...
  24. ncbi Misoprostol versus oxytocin for the reduction of postpartum blood loss
    T F Baskett
    Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, Nova Scotia, Canada
    Int J Gynaecol Obstet 97:2-5. 2007
    To compare the effect of 400 mug of oral misoprostol with 5 U of intravenous oxytocin in the reduction of postpartum blood loss and prevention of postpartum hemorrhage.
  25. pmc Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol
    Kang Nyeong Lee
    Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:1074-80. 2011
    ..This study was conducted to compare the efficacy and safety of DA-9601 with misoprostol for preventing NSAID-associated gastroduodenal injury...
  26. ncbi Misoprostol: first-line therapy for incomplete miscarriage in the developing world
    K Gemzell-Danielsson
    Department of Woman and Child Health, Division for Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden
    BJOG 114:1337-9. 2007
  27. pmc Helping rural women in Pakistan to prevent postpartum hemorrhage: a quasi experimental study
    Ali Mohammad Mir
    Population Council, Islamabad, Pakistan
    BMC Pregnancy Childbirth 12:120. 2012
    ..The objectives of the study were to document the feasibility of distribution of misoprostol tablets by community-based providers mainly traditional birth attendants and acceptability and use of ..
  28. ncbi Misoprostol for preventing and treating postpartum hemorrhage in the community: a closer look at the evidence
    Olufemi T Oladapo
    Maternal and Fetal Health Research Unit, Department of Obstetrics and Gynecology, Olabisi Onabanjo University Teaching Hospital, P M B 2001, Sagamu, Ogun State, Nigeria
    Int J Gynaecol Obstet 119:105-10. 2012
    The lack of clear interpretation of clinical and operational evidence on misoprostol use for postpartum hemorrhage (PPH) in the community may jeopardize the realization of its full potential for improving women's survival...
  29. pmc Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy
    Hidetoshi Taniguchi
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurosci Lett 504:185-90. 2011
    ..of EP1 signaling with the selective antagonist SC-51089 or co-activation of EP2-4 receptors with the agonist misoprostol significantly reduced HIE cerebral injury 24 h after injury...
  30. ncbi Pharmacy provision of medical abortifacients in a Latin American city
    Diana Lara
    Population Council, Regional Office for Latin America and the Caribbean, Mexico City 04000, Mexico
    Contraception 74:394-9. 2006
    ..Nonetheless, previous research suggest that women frequently use misoprostol to self-induce abortion. In many settings, women obtain the medication from a pharmacy...
  31. ncbi The effect of misoprostol on postpartum contractions: a randomised comparison of three sublingual doses
    A Elati
    School of Women s and Children s Health, Liverpool Women s Hospital, University of Liverpool, UK
    BJOG 118:466-73. 2011
    To compare the postpartum uterine activity and side effects of various doses of sublingual misoprostol and intramuscular oxytocin.
  32. pmc Sublingual misoprostol versus standard surgical care for treatment of incomplete abortion in five sub-Saharan African countries
    Tara Shochet
    Gynuity Health Projects, 15 E, 26th St, Suite 801, New York, NY 10010, USA
    BMC Pregnancy Childbirth 12:127. 2012
    ..Standard post-abortion care has involved surgical intervention but can be hard to access in these areas. Misoprostol provides an alternative to surgical intervention that could increase access to abortion care...
  33. ncbi Results and lessons learned from a small medical abortion clinical study in Turkey
    Ayse Akin
    Haceteppe University Medical School, Department of Public Health, Ankara, Turkey
    Contraception 70:401-6. 2004
    ..All eligible consenting women were given 200 mg oral mifepristone at the clinic followed by 400 microg oral misoprostol 2 days later either at home or at the clinic. The overall success rate of 84...
  34. ncbi A randomized controlled trial of 400-μg sublingual misoprostol versus manual vacuum aspiration for the treatment of incomplete abortion in two Egyptian hospitals
    Rasha Dabash
    Gynuity Health Projects, New York, USA
    Int J Gynaecol Obstet 111:131-5. 2010
    To compare the safety, efficacy, and acceptability of 400-μg sublingual misoprostol with that of manual vacuum aspiration (MVA) in 2 Egyptian hospitals.
  35. ncbi Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells
    Javaneh Tamiji
    School of Kinesiology and Health Science, York University, Toronto, Canada
    Biochem Biophys Res Commun 398:450-6. 2010
    ..The prenatal exposure to the drug misoprostol, a prostaglandin type E analogue, has also been linked to a number of neurodevelopmental defects...
  36. ncbi Misoprostol for treatment of incomplete abortion at the regional hospital level: results from Tanzania
    B Shwekerela
    Kagera Regional Hospital, Bukoba, Tanzania
    BJOG 114:1363-7. 2007
    To investigate the safety, efficacy, and acceptability of misoprostol versus manual vacuum aspiration (MVA) for treatment of incomplete abortion.
  37. ncbi Evacuation interval after vaginal misoprostol for preabortion cervical priming: a randomized trial
    K Singh
    Department of Obstetrics and Gynaecology, National University Hospital, Singapore
    Obstet Gynecol 94:431-4. 1999
    To determine the optimal interval for evacuation after preabortion cervical priming with vaginal misoprostol.
  38. ncbi How often and under which circumstances do Mexican pharmacy vendors recommend misoprostol to induce an abortion?
    Diana Lara
    Ibis Reproductive Health, Oakland, CA, USA
    Int Perspect Sex Reprod Health 37:75-83. 2011
    b>Misoprostol was used by women across Mexico to induce abortion even before 2007, when first-trimester abortion was legalized in Mexico City...
  39. ncbi A prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages
    Oi Shan Tang
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Hum Reprod 18:176-81. 2003
    A randomized controlled trial comparing sublingual with vaginal administration of misoprostol for medical management of silent miscarriages.
  40. ncbi Comparison between the sublingual and oral route of misoprostol for pre-abortion cervical priming in first trimester abortions
    Pikee Saxena
    Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
    Hum Reprod 19:77-80. 2004
    b>Misoprostol has been used for achieving cervical priming before suction evacuation (SE) by the oral or vaginal route, although both routes have their shortcomings...
  41. ncbi Cervical dilation in second-trimester abortion
    Jennifer L Hayes
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburg, PA 15213, USA
    Clin Obstet Gynecol 52:171-8. 2009
    ..prepared with osmotic dilators such as laminaria, Lamicel, or Dilapan-S, or with pharmacologic agents such as misoprostol. Dilapan-S and Lamicel achieve their maximum dilation faster than laminaria, making same-day procedures ..
  42. ncbi Pilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation: efficacy and acceptability
    Oi Shan Tang
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Hum Reprod 17:654-8. 2002
    A sublingual misoprostol-alone regimen was used in 50 women requesting medical abortion at up to 12 weeks gestation. The efficacy and acceptability of this regimen were studied.
  43. ncbi Double-blind, randomized, placebo-controlled study on the effect of misoprostol on ease of consecutive insertion of the levonorgestrel-releasing intrauterine system
    Oskari Heikinheimo
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Contraception 81:481-6. 2010
    b>Misoprostol has been studied intensively to produce cervical dilatation. To date, no studies have evaluated the effectiveness, safety or acceptability of this treatment for repeat intrauterine device insertions.
  44. ncbi Oral misoprostol for prevention of postpartum hemorrhage by paramedical workers in India
    N Chandhiok
    Division of Reproductive Health and Nutrition, Indian Council of Medical Research, Ansari Nagar, New Delhi
    Int J Gynaecol Obstet 92:170-5. 2006
    To study whether paramedical workers from rural primary health centers in India are able to administer oral misoprostol and actively manage the third stage of labor to prevent postpartum hemorrhage (PPH).
  45. ncbi Mifepristone-misoprostol abortion: a trial in rural and urban Maharashtra, India
    Kurus Coyaji
    K E M Hospital, Pune, India
    Contraception 66:33-40. 2002
    ..abortion in developing countries, we investigated the safety, efficacy, and acceptability of mifepristone-misoprostol abortion in the outpatient family planning departments of two urban hospitals and one rural hospital in India...
  46. ncbi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial
    Beverly Winikoff
    Gynuity Health Projects, New York, NY, USA
    Lancet 375:210-6. 2010
    ..b>Misoprostol, an effective uterotonic agent with several advantages for resource-poor settings, has been investigated as an ..
  47. ncbi Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women receiving prophylactic oxytocin: a double-blind, randomised, non-inferiority trial
    Jennifer Blum
    Gynuity Health Projects, New York, NY 10010, USA
    Lancet 375:217-23. 2010
    ..b>Misoprostol, a potential alternative, is increasingly used ad hoc for treatment of post-partum haemorrhage; however, ..
  48. ncbi Community-based availability of misoprostol: is it safe?
    Ndola Prata
    School of Public Health, University of California, Berkeley, University Hall, Berkeley, CA 94720 7360, USA
    Afr J Reprod Health 13:117-28. 2009
    This paper evaluates the safety and acceptability of long-term community-based use of misoprostol for management of postpartum hemorrhage (PPH) in home-births, by comparing deliveries with and without misoprostol use in communities of ..
  49. ncbi Autism and Möbius sequence: an exploratory study of children in northeastern Brazil
    José Marcelino Bandim
    Departamento de Neuropsiquiatria, Universidade Federal de Pernambuco, Recife, PE, Brasil
    Arq Neuropsiquiatr 61:181-5. 2003
    ..Among five children with autism, three (60%) had positive history of misoprostol exposure during the first trimester of pregnancy and from two cases autistic-like, one (50%) had positive ..
  50. ncbi Effects of misoprostol on uterine contractility following different routes of administration
    A Aronsson
    Department of Woman and Child Health, Division for Obstetrics and Gynaecology, Karolinska Institute Hospital, S 171 76 Stockholm, Sweden
    Hum Reprod 19:81-4. 2004
    The effect of misoprostol administered by different routes on pregnant uterine contractility was investigated.
  51. ncbi Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Gastroenterol Hepatol 6:1279-82. 2008
    With capsule endoscopy, the ulcerogenic effect of low-dose enteric-coated aspirin on the small bowel and the therapeutic effect of misoprostol on intestinal injury were evaluated.
  52. ncbi Misoprostol and declining abortion-related morbidity in Santo Domingo, Dominican Republic: a temporal association
    Suellen Miller
    Women s Global Health Imperative, Department of Obstetrics and Gynecology, University of California, San Francisco, California 94105 3444, USA
    BJOG 112:1291-6. 2005
    To validate anecdotal reports that abortion-related complications decreased in the Dominican Republic after the introduction of misoprostol into the country.
  53. ncbi Assessing the global availability of misoprostol
    Maria M Fernandez
    Product Promotion and Distribution Unit, Ipas, Chapel Hill, North Carolina, USA
    Int J Gynaecol Obstet 105:180-6. 2009
    To assess the worldwide availability of misoprostol. Documenting the extent of misoprostol use in obstetrics-gynecology is difficult because the drug typically is unregistered for such indications.
  54. ncbi Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor
    Rehan Uddin Khan
    Division of Maternal and Fetal Medicine, Imperial College School of Medicine, London, United Kingdom
    Obstet Gynecol 101:968-74. 2003
    To characterize the pharmacokinetics and adverse-effect profile of rectally administered misoprostol.
  55. ncbi Misoprostol administered by epithelial routes: Drug absorption and uterine response
    Karen R Meckstroth
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA
    Obstet Gynecol 108:582-90. 2006
    To quantify and compare serum levels and uterine effects following vaginal (dry), vaginal (moistened), buccal, and rectal misoprostol administration.
  56. ncbi The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy
    Annette Aronsson
    Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Institute, S 171 76 Stockholm, Sweden
    Contraception 72:33-9. 2005
    The objective of the present study was to investigate the effect of vaginally and orally administered misoprostol on the local cervical inflammatory response.
  57. ncbi Two routes of administration for misoprostol in the treatment of incomplete abortion: a randomized clinical trial
    Ayisha Diop
    Gynuity Health Projects, New York, NY 10010, USA
    Contraception 79:456-62. 2009
    This study was conducted to compare the safety, effectiveness and acceptability of 400 mcg sublingual misoprostol and 600 mcg oral misoprostol for treatment of incomplete abortion.
  58. ncbi Home self-administration of vaginal misoprostol for medical abortion at 50-63 days compared with gestation of below 50 days
    H Kopp Kallner
    Division of Obstetrics and Gynaecology, Department of Women s and Children s Health, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Hum Reprod 25:1153-7. 2010
    Home use of misoprostol for termination of pregnancy is still controversial in many countries. Acceptability of home use of misoprostol has been investigated in pregnancies below 49 days gestation...
  59. ncbi Misoprostol dose and route after mifepristone for early medical abortion: a randomised controlled noninferiority trial
    H von Hertzen
    Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    BJOG 117:1186-96. 2010
    To compare 400 and 800 microg sublingual or vaginal misoprostol 24 hours after 200 mg mifepristone for noninferiority regarding efficacy in achieving complete abortion for pregnancy termination up to 63 days of gestation.
  60. ncbi A comparison of tamoxifen and misoprostol to misoprostol alone for early pregnancy termination
    J K Jain
    Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Contraception 60:353-6. 1999
    A study was undertaken to determine whether the combination of oral tamoxifen and moistened misoprostol administered vaginally was superior to that of placebo and moistened misoprostol administered vaginally for elective termination of ..
  61. ncbi Prevention of postpartum hemorrhage with misoprostol
    Z Alfirevic
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
    Int J Gynaecol Obstet 99:S198-201. 2007
    As a stable, orally active and cheap uterotonic, misoprostol would appear ideally suited to the prevention of postpartum hemorrhage (PPH) in the developing world...
  62. ncbi Acceptability and feasibility of early pregnancy termination by mifepristone-misoprostol. Results of a large multicenter trial in the United States. Mifepristone Clinical Trials Group
    B Winikoff
    Population Council, New York, NY, USA
    Arch Fam Med 7:360-6. 1998
    To evaluate whether the regimen of oral mifepristone and misoprostol for medical abortion is acceptable to women and providers, in the United States, including physicians, nurses, and counselors, and whether proposed modifications of ..
  63. ncbi Assessment of pain after elective abortion relating to the use of misoprostol for dilatation of the cervix
    Alexandra Gagné
    Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Quebec, Quebec QC
    J Obstet Gynaecol Can 32:244-53. 2010
    Our objective was to compare the use of misoprostol to that of laminaria tents for dilatation of the cervix before a surgical elective abortion (EAB) during the first trimester, with regard to the pain caused (1) during insertion, for ..
  64. pmc A cost-effectiveness analysis of surgical versus medical management of early pregnancy loss
    Mary Rausch
    North Shore University Hospital, Manhasset, New York, USA
    Fertil Steril 97:355-60. 2012
    ..To determine the cost-effectiveness of medical and surgical management of early pregnancy loss...
  65. ncbi Economic evaluation of misoprostol in the treatment of early pregnancy failure compared to curettage after an expectant management
    G C M Graziosi
    Department of Obstetrics and Gynaecology, St Antonius Hospital, Koekoekslaan 1, Nieuwegein, The Netherlands
    Hum Reprod 20:1067-71. 2005
    ..Direct and indirect costs of a strategy starting with misoprostol in treatment of early pregnancy failure as compared to curettage is therefore performed.
  66. ncbi Introduction of misoprostol for prevention of postpartum hemorrhage at the community level in Senegal
    Mohamed Diadhiou
    Centre de Formation et de Recherche en Santé de la Reproduction, Maternité Hôpital Aristide Le Dantec, Dakar, Senegal
    Int J Gynaecol Obstet 115:251-5. 2011
    To demonstrate that training ensures correct administration of oral misoprostol by auxiliary midwives for prevention of postpartum hemorrhage (PPH) among women giving birth at the community level in Senegal.
  67. ncbi Sublingual misoprostol versus oxytocin infusion to reduce blood loss at cesarean section
    N Vimala
    Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi
    Int J Gynaecol Obstet 92:106-10. 2006
    To compare the effectiveness of sublingual misoprostol administered immediately after delivery of the neonate at cesarean section, with intravenous oxytocin infusion in prevention of uterine atony and thereby reducing blood loss at ..
  68. ncbi Termination of second-trimester pregnancy by mifepristone combined with misoprostol versus intra-amniotic injection of ethacridine lactate (Rivanol®): a systematic review of Chinese trials
    Shu Ping Hou
    Department of Gynecology and Obstetrics, The Sixth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China
    Contraception 84:214-23. 2011
    Mifepristone combined with misoprostol for second-trimester abortion (MM) and intra-amniotic injection of ethacridine lactate (EL; Rivanol®) are the common methods for termination of second-trimester pregnancy in China...
  69. ncbi A comparison of medical management with misoprostol and surgical management for early pregnancy failure
    Jun Zhang
    Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    N Engl J Med 353:761-9. 2005
    b>Misoprostol is increasingly used to treat women who have a failed pregnancy in the first trimester. We assessed the efficacy, safety, and acceptability of this treatment in a large, randomized trial.
  70. ncbi Systematic review of randomized controlled trials of misoprostol to prevent postpartum hemorrhage
    J Villar
    United Nations Development Programme United Nations Population Fund World Health Organization World Bank Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Geneva, Switzerland
    Obstet Gynecol 100:1301-12. 2002
    To assess the effects of prophylactic misoprostol use in the third stage of labor compared with injectable uterotonics or placebo or no treatment.
  71. ncbi Treating miscarriages: a randomised study of cost-effectiveness in medical or surgical choice
    M Niinimaki
    Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
    BJOG 116:984-90. 2009
    ..The aim was to carry out a cost effectiveness analysis (CEA) of medical and surgical treatment of miscarriage using quantitative and qualitative indicators...
  72. ncbi Randomised trial of intravaginal misoprostol and intracervical Foley catheter for cervical ripening and induction of labour
    A T Owolabi
    Department of Obstetrics, Gynaecology and Perinatology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
    J Obstet Gynaecol 25:565-8. 2005
    ..The purpose of this study was to compare the safety and efficacy of intravaginal misoprostol and an intracervical Foley's balloon catheter for preinduction cervical ripening and labour induction...
  73. ncbi A randomized study comparing rectally administered misoprostol versus Syntometrine combined with an oxytocin infusion for the cessation of primary post partum hemorrhage
    A U Lokugamage
    Department of Obstetrics and Gynaecology, Royal Free and University College London School, Gower Street Campus, 86 96 Chenies Mews, London WC1E 6HX, UK
    Acta Obstet Gynecol Scand 80:835-9. 2001
    ..Hemorrhage can occur despite active management of the third stage of labor. Presently, misoprostol (Cytotec, Searle Pharmaceuticals) is the only thermostable uterotonic agent potentially available which would ..
  74. ncbi Postpartum misoprostol for preventing maternal mortality and morbidity
    G Justus Hofmeyr
    Department of Obstetrics and Gynaecology, East London Hospital Complex, University of the Witwatersrand, University of FortHare, Eastern Cape Department of Health, East London, South
    Cochrane Database Syst Rev 7:CD008982. 2013
    The primary objective of postpartum haemorrhage (PPH) prevention and treatment is to reduce maternal deaths. Misoprostol has the major public health advantage over injectable medication that it can more easily be distributed at community ..
  75. ncbi Increasing women's choices in medical abortion: a study of misoprostol 400 microg swallowed immediately or held sublingually following 200 mg mifepristone
    Ayse Akin
    Hacettepe University School of Medicine, Ankara, Turkey
    Eur J Contracept Reprod Health Care 14:169-75. 2009
    To assess the efficacy and acceptability of two misoprostol regimens (400 microg oral or sublingual) following mifepristone for medical abortion.
  76. ncbi Effects of prophylactic misoprostol administration prior to intrauterine device insertion in nulliparous women
    Alison B Edelman
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
    Contraception 84:234-9. 2011
    This study was conducted to examine the effects of prophylactic misoprostol prior to intrauterine device (IUD) placement in nulliparous women.
  77. ncbi Evaluation of the introduction of a new treatment for the termination of pregnancy in The Netherlands
    Joseph F G M Brouns
    Department of Obstetrics and Gynecology, Zaans Medical Center, Zaandam, The Netherlands
    Acta Obstet Gynecol Scand 89:1210-3. 2010
    ..Suboptimal treatment regimens will frustrate patients and doctors and deprive future patients from the most efficacious and patient friendly treatment regimes available...
  78. ncbi Monitoring medical abortion using mifepristone/misoprostol combination with ultrasonogram and serum human chorionic gonadotropin
    Szu Yuan Chou
    Department of Obstetrics and Gynecology, Taipei Medical University Wan Fang Medical Center, Taipei, Taiwan
    Taiwan J Obstet Gynecol 45:48-52. 2006
    The oral mifepristone/misoprostol combination (MMC) is safe for medical abortion in early pregnancy...
  79. ncbi A randomized controlled trial of different buccal misoprostol doses in mifepristone medical abortion
    Erica Chong
    Gynuity Health Projects, New York, NY 10010, USA
    Contraception 86:251-6. 2012
    An 800-mcg dose of buccal misoprostol following mifepristone has been shown to be highly effective in terminating pregnancies through 63 days since the last menstrual period (LMP) (B. Winikoff, I.G. Dzuba, M.D. Creinin, et al...
  80. ncbi Management of early pregnancy loss
    G C M Graziosi
    Department of Obstetrics and Gynecology, St Antonius Hospital, Nieuwegein, The Netherlands
    Int J Gynaecol Obstet 86:337-46. 2004
    ..In order to assess the available evidence on the management of early pregnancy loss, we performed a meta-analysis on the subject...
  81. pmc High fever following postpartum administration of sublingual misoprostol
    J Durocher
    Gynuity Health Projects, New York, NY, USA
    BJOG 117:845-52. 2010
    To explore what triggers an elevated body temperature of > or =40.0 degrees C in some women given misoprostol, a prostaglandin E1 analogue, for postpartum haemorrhage (PPH).
  82. pmc Endometrial thickness after misoprostol use for early pregnancy failure
    M D Creinin
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Womens Research Institute, Pittsburgh, PA, USA
    Int J Gynaecol Obstet 86:22-6. 2004
    To assess if there was any potential relationship between endometrial thickness and final treatment outcome in women successfully treated with misoprostol for a first trimester anembryonic gestation, embryonic demise or fetal demise.
  83. ncbi Early termination of pregnancy by single-dose 800 microg misoprostol compared with surgical evacuation
    Sudha Prasad
    Department of Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, India
    Fertil Steril 91:28-31. 2009
    To assess the efficacy, safety, and acceptability of early termination of pregnancy by vaginal administration of a single dose of misoprostol.
  84. ncbi Misoprostol versus curettage in women with early pregnancy failure after initial expectant management: a randomized trial
    G C M Graziosi
    Department of Obstetrics and Gynaecology, St Antonius Hospital, Koekoekslaan 1, Nieuwegein, The Netherlands
    Hum Reprod 19:1894-9. 2004
    Little is known about the effectiveness of misoprostol treatment in women with early pregnancy failure who have been managed expectantly. We therefore performed a randomized trial on this subject.
  85. ncbi Two distinct oral routes of misoprostol in mifepristone medical abortion: a randomized controlled trial
    Beverly Winikoff
    Gynuity Health Projects, New York, New York 10010, USA
    Obstet Gynecol 112:1303-10. 2008
    To study the efficacy, safety, and acceptability of oral immediately swallowed and buccal misoprostol 800 mcg after mifepristone 200 mg for terminating pregnancy through 63 days since the last menstrual period (LMP).
  86. ncbi Misoprostol versus cervagem for the induction of labour to terminate pregnancy in the second and third trimester: a systematic review
    Jodie M Dodd
    Maternal Fetal Medicine Specialist, Department of Obstetrics and Gynaecology, The University of Adelaide, 72 King William Road, North Adelaide 5006, Australia
    Eur J Obstet Gynecol Reprod Biol 125:3-8. 2006
    to compare the benefits and harms of misoprostol to induce labour in the second and third trimester of pregnancy with cervagem.
  87. ncbi Acceptability of home-use of misoprostol in medical abortion
    Christian Fiala
    Division for Obstetrics and Gynaecology, Department of Woman and Child Health, Karolinska Hospital Institute, S 171 76 Stockholm, Sweden
    Contraception 70:387-92. 2004
    Home-use of misoprostol would reduce the number of visits and improve access to medical abortion. We evaluated acceptance of home-use of misoprostol among women and their partners.
  88. ncbi Rectal versus oral misoprostol for active management of third stage of labor: a randomized controlled trial
    H A Mansouri
    King Abdulaziz University Hospital, Jeddah, Saudi Arabia
    Arch Gynecol Obstet 283:935-9. 2011
    To test that rectal misoprostol is effective for active management of third stage of labor, and probably with less side effects than oral misoprostol.
  89. ncbi Mifepristone and misoprostol administered simultaneously versus 24 hours apart for abortion: a randomized controlled trial
    Mitchell D Creinin
    Department of Obstetrics, Gynecology and Reproductive Sciences and Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3180, USA
    Obstet Gynecol 109:885-94. 2007
    Mifepristone and oral misoprostol are typically used for medical abortion in women up to 49 days of gestation, with a 36- to 48-hour interval between the medications...
  90. ncbi Prostaglandin analogue misoprostol attenuates neurotoxin 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells
    Eun Joo Choi
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Brain Res Bull 77:293-300. 2008
    ..The present study assessed the preventive effect of a prostaglandin E(1) analogue misoprostol against the toxicity of parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) with respect to the ..
  91. ncbi Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected
    Marilyn T Miller
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Birth Defects Res A Clin Mol Teratol 85:667-76. 2009
    ..American children who were born after an unsuccessful attempt to induce abortion with the prostaglandin drug misoprostol (Cytotec). Aberrant tearing also occurs in some individuals with Möbius syndrome...
  92. ncbi Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration
    Franco Ghezzo
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, I 10043 Orbassano TO, Italy
    Int J Oncol 26:697-702. 2005
    ..Although misoprostol is a prostaglandin analogous its concomitant administration did not compromise the salicylate anti-tumour effect...
  93. ncbi Comparison of sublingual misoprostol, intravenous oxytocin, and intravenous methylergometrine in active management of the third stage of labor
    Gunjan Singh
    Department of Obstetrics and Gynecology, University College of Medical Sciences, Guru Teg Bahadur Hospital, New Delhi, India
    Int J Gynaecol Obstet 107:130-4. 2009
    To compare the efficacy and adverse effects of sublingual misoprostol, intravenous oxytocin, and intravenous methylergometrine in active management of the third stage of labor (AMTSL).
  94. ncbi Treatment of incomplete abortion and miscarriage with misoprostol
    J Blum
    Gynuity Health Projects, New York, NY 10010, USA
    Int J Gynaecol Obstet 99:S186-9. 2007
    A literature review was conducted to determine whether misoprostol is an effective treatment for incomplete abortion and, if so, to recommend an appropriate regimen...
  95. ncbi Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery
    Yap Seng Chong
    Department of Obstetrics and Gynaecology, National University of Singapore, Singapore, Singapore
    Eur J Obstet Gynecol Reprod Biol 113:191-8. 2004
    To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes.
  96. ncbi A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misoprostol for medical abortions of less than 9 weeks gestation
    Oi Shan Tang
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Hum Reprod 18:2315-8. 2003
    A combination of mifepristone and misoprostol provides an effective method of medical abortion for early pregnancy...
  97. ncbi Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: A randomized trial
    E A Schaff
    Reproductive Health Program, Department of Family Medicine, University of Rochester School of Medicine, 1000 South Ave, Box 101, Rochester, NY 14620, USA
    JAMA 284:1948-53. 2000
    The conventional timing of misoprostol administration after mifepristone for medical abortion is 2 days, but more flexible intervals, which may make the regimen more convenient, have not been studied.
  98. pmc Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483
    E Totsuka
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, PA 15213 2582, USA
    J Am Coll Surg 187:276-86. 1998
    ..This study investigated whether misoprostol, prostaglandin E1 analogue, and OP-41483, prostaglandin I2 analogue, which have fewer adverse effects with a ..
  99. ncbi Intravaginal misoprostol versus Foley catheter for labour induction: a meta-analysis
    N S Fox
    Maternal Fetal Medicine Associates, PLLC, New York, USA
    BJOG 118:647-54. 2011
    There are a number of agents used for cervical ripening prior to the induction of labour. Two commonly used agents are intravaginal misoprostol and a transcervical Foley catheter.
  100. ncbi Endometrial thickness and serum beta-hCG as predictors of the effectiveness of oral misoprostol in early pregnancy failure
    Sahar M Y El-Baradie
    Department of Obstetrics and Gynecology, Al Fayom University, Egypt
    J Obstet Gynaecol Can 30:877-81. 2008
    To evaluate ultrasonographic measurement of endometrial thickness and serum levels of chorionic gonadotropin (beta-hCG) as predictors of failure to abort completely in patients designated for uterine evacuation using oral misoprostol.
  101. ncbi Early medical abortion using low-dose mifepristone followed by buccal misoprostol: a large Australian observational study
    Philip Goldstone
    Marie Stopes International Australia, Melbourne, Vic, Australia
    Med J Aust 197:282-6. 2012
    To describe the use of mifepristone in combination with buccal misoprostol in women undergoing an early medical abortion (EMA) in Australia.

Research Grants33

  1. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..Evaluate the effects of combined consumption of a commercially- available adenyl cyclase agonist (Misoprostol - increases cAMP production) and a phosphodiesterase inhibitor (Pentoxyfilline - decreases cAMP breakdown) in ..
  2. Role of misoprostol in Clostridium sordellii endometritis in a rodent model
    David M Aronoff; Fiscal Year: 2012
    ..DESCRIPTION (provided by applicant): The combination oral regimen of mifepristone (MFP;also known as RU-486) and misoprostol was FDA approved in 2000 to induce abortion medically...
  3. Comparative Effectiveness of Pregnancy Failure Management Regimens (Pre-Fai-R)
    Courtney A Schreiber; Fiscal Year: 2013
    ..management of early pregnancy failure has led to the wide-spread use of prostaglandin analogues, specifically misoprostol, for uterine evacuation...
  4. GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISM
    Patricia Rodier; Fiscal Year: 2007
    ..people exposed in utero to three teratogens known to be associated with autism: thalidomide, valproic acid, and misoprostol. The investigators propose to determine whether the members of these populations who meet diagnostic criteria ..
  5. PROSTAGLANDIN THERAPY FOR ALCOHOLIC HEPATITIS
    Daniell Hill; Fiscal Year: 2004
    ..The "anticytokine" therapy to be studied in this proposal is the prostaglandin E1 analogue misoprostol. We postulated that misoprostol will both inhibit cytokine production and improve gut permeability...
  6. INTRAVAGINAL CONTROLLED DELIVERY OF MISOPROSTOL
    SHALABY SHALABY; Fiscal Year: 1999
    ..Recently, misoprostol has received considerable interest because of its superior clinical efficacy, ease of administration, and cost...
  7. MUCOSAL IMMUNITY AND ORAL TOLERANCE--INNATE IMMUNITY
    Carol Tacket; Fiscal Year: 2001
    ..tolerance, volunteers will be randomized to receive either placebo, rofecoxib, a selective cox-2 inhibitor, or misoprostol, a long-acting prostaglandin E1 analog during oral immunization...
  8. BIOBEHAVIORAL INTERVENTIONS FOR ORAL PAIN AND MUCOSITIS
    Deborah McGuire; Fiscal Year: 2001
    ..care The primary aim of this project is to test whether a comprehensive biobehavioral intervention combining misoprostol (a prostaglandin E1 analogue) with psychoeducation that systematically includes family caregivers will reduce ..
  9. Obesity, Oral Contraception and Ovarian Suppression
    Carolyn Westhoff; Fiscal Year: 2007
    ..This study will have very good power to detect clinically important differences. Results could directly and immediately affect contraceptive practice. ..
  10. RCT of a Novel Oral Contraceptive Initiation Method
    Carolyn Westhoff; Fiscal Year: 2004
    ..We will also assess dual method use for STD prevention in the study to adoption of and adherence to oral contraceptives. We will also assess dual method use for STD prevention in the study population. ..
  11. Oral contraceptives and cytochrome p450 inducers
    Anne Davis; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. ORAL CONTRACEPTIVES FOR DYSMENORRHEA IN ADOLESCENT GIRLS
    Anne Davis; Fiscal Year: 2002
    ..Given their efficacy in pregnancy prevention, safety, and non-contraceptive health benefits, COC may be an ideal therapy for primary dysmenorrhea in adolescent girls. ..
  13. Contraceptive efficacy and body weight: Does obesity affect the risk of failure?
    Alison Edelman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. CARTILAGE CELL AND MATRIX RESPONSE TO JOINT LOADING
    Peter Torzilli; Fiscal Year: 2008
    ..If, as we believe, two distinct initiation mechanisms exist, then this would significantly alter how we study each disease process and how we will need to treat them to prevent the progression of the disease. [unreadable] [unreadable]..
  15. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..of growth plate function by fractionation and the radioprotectants amifostine [WR-2721], pentoxifylline, misoprostol, selenium, and IL-1a...
  16. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  17. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  18. Improving Contraceptive Effectiveness in Obese Women
    Alison B Edelman; Fiscal Year: 2010
    ..abstract_text> ..
  19. ESTIMATING EFFICACY OF A MEDICAL INTERVENTION
    James Trussell; Fiscal Year: 2001
    ....
  20. Sleep Fragmentation Effects on Murine CII-Induced AR
    Arnold Postlethwaite; Fiscal Year: 2003
    ..Results of the study will provide a basis for submitting an R01 grant to explore mechanisms by which partial sleep deprivation in DBA/1 lac mice alter the immune response to antigen and arthritis development. ..
  21. SCOR on the Pathogenesis of Scleroderma
    Arnold Postlethwaite; Fiscal Year: 2005
    ..abstract_text> ..
  22. CII ORAL TOLERANCE INDUCTION IN RA PATIENTS OFF NSAIDS
    Arnold Postlethwaite; Fiscal Year: 2001
    ..In summary, by withdrawing NSAIDs, which interfere with oral tolerance induction, from RA patients we believe this study will fully explore the therapeutic potential of oral CII tolerance induction in RA. ..
  23. PDE3 Inhibitors: Selective Blockers of Oocyte Maturation
    Jeffrey Jensen; Fiscal Year: 2007
    ..This approach is expected to provide a foundation for future Phase 1 trials of PDE3 inhibitors in humans. ..
  24. Cartilage Degeneration Following Joint Trauma
    Peter Torzilli; Fiscal Year: 2003
    ....
  25. Pathogenic Mechanisms of Fibrosis:Common Ground
    Arnold Postlethwaite; Fiscal Year: 2004
    ..Young investigator travel awards are being provided to encourage involvement of trainees and other young investigators. ..
  26. DEFORMATION-DEPENDENT ENZYME CLEAVAGE OF COLLAGEN
    Peter Torzilli; Fiscal Year: 2005
    ..The findings from this study could fundamentally change our concepts of matrix enzyme function and the design of intervention approaches to include the effect the mechanical environment has on the ECM. ..
  27. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  28. Rheumatic Disease Research Core Center
    Arnold Postlethwaite; Fiscal Year: 2006
    ..Strong institutional support for rheumatology, superior physical resources, and a favorable intellectual environment combine to make this an opportune time to establish an RDCC at this institution. ..
  29. RESEARCH TRAINING IN CONNECTIVE TISSUE DISEASES
    Arnold Postlethwaite; Fiscal Year: 2008
    ..The trainees will be qualified persons with MD or PhD degrees. We have requested three trainee positions be supported each year of the training grant period (5 years). ..
  30. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  31. Blood Donation and HIV Prevention in China
    Vincanne Adams; Fiscal Year: 2006
    ..Data collection will occur in Shanghai; overall project oversight and data analysis will occur in San Francisco, CA. [unreadable] [unreadable]..
  32. Age, Disruption, and Life Reorganization after Hurricane Katrina
    Vincanne Adams; Fiscal Year: 2010
    ..Examining the process of unwanted change in later life can provide many insights about how people deal with change, the ways they adjust and accommodate it in daily life, and the effects of unwanted change on health and well-being. ..