interleukin 8

Summary

Summary: A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. IL-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4.

Top Publications

  1. ncbi Interleukin-8 as a macrophage-derived mediator of angiogenesis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611
    Science 258:1798-801. 1992
  2. doi The interleukin-8 pathway in cancer
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 14:6735-41. 2008
  3. ncbi Multiple control of interleukin-8 gene expression
    Elke Hoffmann
    Institute of Pharmacology, Medical School Hannover, Germany
    J Leukoc Biol 72:847-55. 2002
  4. doi Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    Thomas Kuilman
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cell 133:1019-31. 2008
  5. doi Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, Northern Ireland BT9 7BL, United Kingdom
    Mol Cancer Ther 7:2649-61. 2008
  6. ncbi Regulation of interleukin-8 gene expression
    K A Roebuck
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Interferon Cytokine Res 19:429-38. 1999
  7. ncbi Interleukin-8 and human cancer biology
    K Xie
    Department of Gastrointestinal Medical Oncology and Cancer Biology, M D Anderson Cancer Center, The University of Texas, Box 78, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cytokine Growth Factor Rev 12:375-91. 2001
  8. ncbi Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
    Jeremy J W Chen
    Institute of Biomedical Sciences and Molecular Biology, National Chung Hsing University, Taichung, Taiwan 402, Republic of China
    Clin Cancer Res 9:729-37. 2003
  9. ncbi p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment
    Simona Saccani
    Institute for Research in Biomedicine, Via Vela 6, CH 6501, Bellinzona, Switzerland
    Nat Immunol 3:69-75. 2002
  10. ncbi Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection
    Yoshio Yamaoka
    Department of Medicine, Veterans Affairs Medicial Center and Baylor College of Medicine, Houston, TX 77030, USA
    Gastroenterology 126:1030-43. 2004

Research Grants

  1. BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILS
    Mimi Takami; Fiscal Year: 2003
  2. Emilio B Gonzalez; Fiscal Year: 2014
  3. Jonathan Savitz; Fiscal Year: 2016
  4. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
  5. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
  6. Georgios I Papachristou; Fiscal Year: 2014
  7. Toby C Lewis; Fiscal Year: 2014
  8. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
  9. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
  10. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010

Detail Information

Publications409 found, 100 shown here

  1. ncbi Interleukin-8 as a macrophage-derived mediator of angiogenesis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611
    Science 258:1798-801. 1992
    ..These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair...
  2. doi The interleukin-8 pathway in cancer
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 14:6735-41. 2008
    ..Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention in targeting the tumor microenvironment...
  3. ncbi Multiple control of interleukin-8 gene expression
    Elke Hoffmann
    Institute of Pharmacology, Medical School Hannover, Germany
    J Leukoc Biol 72:847-55. 2002
    ..In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury...
  4. doi Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    Thomas Kuilman
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cell 133:1019-31. 2008
    ..We propose a model in which the context-dependent cytostatic and promitogenic functions of specific interleukins contribute to connect senescence with an inflammatory phenotype and cancer...
  5. doi Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, Northern Ireland BT9 7BL, United Kingdom
    Mol Cancer Ther 7:2649-61. 2008
    ..Therefore, targeted inhibition of IL-8 signaling or c-FLIP expression in prostate cancer may be an attractive therapeutic strategy to sensitize this stage of disease to chemotherapy...
  6. ncbi Regulation of interleukin-8 gene expression
    K A Roebuck
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Interferon Cytokine Res 19:429-38. 1999
    ..This review discusses the regulatory role these higher-order synergistic interactions play in IL-8 transcription and in generation of the stimulus-specific and cell type-specific patterns of IL-8 expression...
  7. ncbi Interleukin-8 and human cancer biology
    K Xie
    Department of Gastrointestinal Medical Oncology and Cancer Biology, M D Anderson Cancer Center, The University of Texas, Box 78, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cytokine Growth Factor Rev 12:375-91. 2001
    ..In this review, the role and regulation of IL-8 expression in the growth and metastasis of human cancer with a focus on human pancreatic adenocarcinoma will be discussed...
  8. ncbi Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
    Jeremy J W Chen
    Institute of Biomedical Sciences and Molecular Biology, National Chung Hsing University, Taichung, Taiwan 402, Republic of China
    Clin Cancer Res 9:729-37. 2003
    ....
  9. ncbi p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment
    Simona Saccani
    Institute for Research in Biomedicine, Via Vela 6, CH 6501, Bellinzona, Switzerland
    Nat Immunol 3:69-75. 2002
    ..These results show that p38 plays an additional role in the induction of the inflammatory and immune response: the regulation of NF-kappa B recruitment to selected chromatin targets...
  10. ncbi Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection
    Yoshio Yamaoka
    Department of Medicine, Veterans Affairs Medicial Center and Baylor College of Medicine, Houston, TX 77030, USA
    Gastroenterology 126:1030-43. 2004
    ..Gastric mucosal interleukin (IL)-8 levels are related to the presence of both the cag pathogenicity island (PAI) and OipA. We investigated the regions of the IL-8 promoter and the upstream signaling involved in IL-8 gene transcription...
  11. ncbi Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation
    F Luppi
    Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Lung Cancer 56:25-33. 2007
    ..These results suggest that IL-8 increases cell proliferation in NSCLC cell lines via transactivation of the EGFR and that this mechanism involves metalloproteinase activity...
  12. pmc CFTR is a negative regulator of NFkappaB mediated innate immune response
    Neeraj Vij
    Department of Pediatric Respiratory Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4664. 2009
    ..The mechanism(s) by which CFTR mediates inflammatory signaling is under debate...
  13. pmc Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
    Nuria de la Iglesia
    Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5870-8. 2008
    ..We also identify the chemokine interleukin 8 (IL8) as a novel target gene of STAT3 in human glioblastoma cells...
  14. pmc Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    S J Polyak
    Department of Laboratory Medicine, Virology Division, University of Washington, 325 9th Ave, Seattle, WA 98104 2499, USA
    J Virol 75:6095-106. 2001
    ..However, NS5A expression in human cells induced interleukin 8 (IL-8) mRNA and protein, and this effect correlated with inhibition of the antiviral effects of IFN in an in ..
  15. ncbi Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
    Se Ran Yang
    Dept of Environmental Medicine, Lung Biology and Disease Program, Univ of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L46-57. 2006
    ..Moreover, cigarette smoke-mediated proinflammatory events are regulated by the redox status of the cells...
  16. ncbi Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia
    Giuseppe Penna
    BioXell, Milan, Italy
    Eur Urol 51:524-33; discussion 533. 2007
    ....
  17. doi Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection
    Kenneth Liu
    Departments of Pharmacology and Medicine, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Biol Chem 283:9977-85. 2008
    ..These results suggest that targeting EGFR may provide a selective therapy that dampens neutrophil-driven inflammation without compromising essential antiviral pathways mediated by pathogen recognition receptors such as TLR3...
  18. doi Interleukin 8 and cardiovascular disease
    Stavros Apostolakis
    Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, 71409 Heraklion, Crete, Greece
    Cardiovasc Res 84:353-60. 2009
    ..In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed...
  19. ncbi The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes
    C G Larsen
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21701
    Science 243:1464-6. 1989
    ..Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes...
  20. pmc Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45
    M Aihara
    Microbiological Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Infect Immun 65:3218-24. 1997
    ..pylori. Collectively, these results suggest that H. pylori induced the activation of NF-kappaB as well as AP-1, leading to IL-8 gene transcription...
  21. pmc The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha
    K S Khabar
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia 11211, USA
    J Exp Med 186:1077-85. 1997
    ..Understanding pathways that antagonize IFN action may lead to novel approaches to potentiate endogenous and therapeutic IFN...
  22. ncbi Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2
    Jan Heidemann
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Biol Chem 278:8508-15. 2003
    ..The chemokine interleukin 8 (IL-8; CXCL8) exerts potent angiogenic properties on endothelial cells through interaction with its cognate ..
  23. ncbi IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR
    Esther A Suswam
    Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA
    Int J Cancer 113:911-9. 2005
    ..the destabilizing factor KSRP. In conclusion, IL-1beta is a potent cytokine stimulus for IL-8 RNA stabilization in breast cancer cells, possibly by enhanced binding of cytoplasmic HuR to the 3'UTR...
  24. ncbi Interleukin-8
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 33:S466-7. 2005
  25. pmc Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 118:202-15. 2006
    ..infantis or L. salivarius, these commensal bacteria exert immunomodulatory effects on intestinal immune cells that mediate host responses to flagellin and enteric pathogens...
  26. ncbi Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 177:148-55. 2008
    ..Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma...
  27. doi Lack of association of a functional polymorphism in the interleukin 8 gene with susceptibility to periodontitis
    Yeon J Kim
    Department of Oral Diagnosis and Surgery, UNESP Sao Paulo State University, Araraquara, Sao Paulo, Brazil
    DNA Cell Biol 28:185-90. 2009
    ..These findings were replicated in the multivariate analysis. The SNP (rs4073) in the IL8 gene is not associated with susceptibility to periodontitis in Brazilian individuals, even after controlling for covariates...
  28. pmc Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Int J Chron Obstruct Pulmon Dis 4:79-86. 2009
    ..Assessment of airway inflammation in the clinical course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) may advance our understanding of the pathogenesis and treatment...
  29. ncbi Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa
    Motonori Fukakusa
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 115:280-6. 2005
    ..Inhaled corticosteroids have been shown to decrease the number of eosinophils and to downregulate T H 2 cytokines but to increase neutrophils. The effect of corticosteroids on chemokine expression in asthma has not yet been investigated...
  30. pmc Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture
    J V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire, USA
    Mucosal Immunol 1:317-25. 2008
    ..Further, it suggests that with E(2) regulation, epithelial cells that line the uterine cavity have evolved immunologically to be sensitive to viral and bacterial infections as well as the constraints of procreation...
  31. ncbi Interleukin 8 and vascular endothelial growth factor -- prognostic factors in human gastric carcinomas?
    S Kido
    First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Eur J Cancer 37:1482-7. 2001
    ..05) than those of patients with tumours displaying low IL-8 and VEGF expression. The results suggest that IL-8 and VEGF may be independent and important prognostic factors in human gastric carcinomas...
  32. ncbi Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
    Yoshio Yamaoka
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:414-24. 2002
    ..The aim was to determine which H. pylori virulence factor(s) was the most important predictor of severity of gastric inflammation or clinical outcome...
  33. ncbi Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB
    Badar M Mian
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:3167-75. 2003
    We previously demonstrated that overexpression of interleukin 8 (IL-8) in human transitional cell carcinoma (TCC) resulted in increased tumorigenicity and metastasis...
  34. pmc The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population
    M Ohyauchi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Gut 54:330-5. 2005
    ..Helicobacter pylori infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process...
  35. ncbi Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550 Japan
    Cancer Epidemiol Biomarkers Prev 14:2487-93. 2005
    ..In conclusion, we showed that the IL-8 -251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer...
  36. pmc Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
    William M Merritt
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:359-72. 2008
    ..Interleukin-8 (IL-8) is a proangiogenic cytokine that is overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 in ovarian carcinoma using human samples and orthotopic mouse models...
  37. pmc High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells
    Thierry Pauloin
    Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    Mol Vis 15:577-83. 2009
    ..The aim of this study was to investigate high molecular weight hyaluronan (HMW-HA) protection on human corneal epithelial (HCE) cells against ultraviolet B (UVB) radiation-induced toxic effects...
  38. ncbi Demonstration of interleukin 8 and autoantibodies to interleukin 8 in the serum of patients with systemic sclerosis and related disorders
    S Reitamo
    Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Arch Dermatol 129:189-93. 1993
    BACKGROUND AND DESIGN--Interleukin 8 (IL-8), a chemotactic cytokine produced by various cell types, displays structural homology to the connective tissue-activating peptide III...
  39. pmc NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    Sabine Brandt
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Proc Natl Acad Sci U S A 102:9300-5. 2005
    ..Thus, CagA is a multifunctional protein capable of effecting both actin remodeling and potentiation of chemokine release...
  40. ncbi Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
    J R White
    Department of Molecular Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 273:10095-8. 1998
    ..This selective antagonist will be a useful tool compound to define the role of CXCR2 in inflammatory diseases where neutrophils play a major role...
  41. pmc Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy
    S J Polyak
    Department of Laboratory Medicine, Virology Division, University of Washington, 325 9th Ave, Seattle, WA 98104 2499, USA
    J Virol 75:6209-11. 2001
    ..This study suggests that HCV-induced changes in levels of chemokine and cytokine expression may be involved in HCV antiviral resistance, persistence, and pathogenesis...
  42. ncbi Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine
    Tor C Savidge
    Developmental Gastroenterology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, USA
    Gastroenterology 125:413-20. 2003
    ..However, toxin A-negative/toxin B-positive strains of C. difficile recently were isolated from patients with antibiotic-associated diarrhea and colitis, indicating that toxin B also may be pathogenic in humans...
  43. ncbi Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase
    Ian R Witherden
    Lung Cell Biology, National Heart and Lung Institute, Imperial College of Science, London, United Kingdom
    Am J Respir Cell Mol Biol 30:500-9. 2004
    ..We hypothesize that reduced ATII cell-derived chemokine levels compromise alveolar repair, contributing to cigarette smoke-induced alveolar damage and emphysema...
  44. pmc Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines
    Taly Weiss
    Department of Cell Biology and Histology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Antimicrob Agents Chemother 48:1974-82. 2004
    ..Its anti-inflammatory properties should be further assessed in clinical settings...
  45. ncbi Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease
    Satoshi Fuke
    First Department of Medicine, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo, Japan, 060 8638
    Am J Respir Cell Mol Biol 31:405-12. 2004
    ....
  46. ncbi Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
    Ina H Benoy
    Translational Cancer Research Group Antwerp, University of Antwerp, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 10:7157-62. 2004
    ..The predictive value of serum IL-8 for the presence of occult metastatic tumor cells in bone marrow aspirates was evaluated in patients with operable and metastatic breast cancer...
  47. ncbi The role of interleukin-8 in cancer cells and microenvironment interaction
    Ang Yuan
    Department of Clinical Research and Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan 100, ROC
    Front Biosci 10:853-65. 2005
    ....
  48. ncbi The role of interleukin-17 during acute rejection after lung transplantation
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit, and Lung Transplantation Unit, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 27:779-87. 2006
    ..These findings suggest that interleukin-17 is important in the pathophysiology of acute lung rejection...
  49. ncbi Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression
    Michael Kline
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Leuk Res 31:591-8. 2007
    ..We conclude that stromal cell IL-8 production parallels MM disease activity, is IL-1beta induced, and correlates with bone marrow angiogenesis...
  50. ncbi TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway
    Mohammad Jamaluddin
    Department of Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1060, USA
    Cell Signal 19:1419-33. 2007
    ..These studies provide insight into a novel antioxidant-sensitive pathway that can be targeted to inhibit NF-kappaB-mediated inflammation...
  51. ncbi G protein-coupled signal transduction pathways for interleukin-8
    D Wu
    Division of Biology, California Institute of Technology, Pasadena 91125
    Science 261:101-3. 1993
    ..These findings suggest that IL-8 acts through signal-transducing pathways that are limited to specific heterotrimeric G proteins and effectors. These may provide suitable targets for the development of anti-inflammatory agents...
  52. ncbi IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
    J Lee
    Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
    J Biol Chem 276:1660-4. 2001
    ..IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8...
  53. ncbi IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuries
    H Kushi
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
    Acta Neurochir Suppl 86:347-50. 2003
    ..The fact that CSF IL-8 was 1000 times that in the peripheral blood at the time of admission, and decreased thereafter, indicates that IL-8 is a key mediator of neuroinflammation...
  54. ncbi Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-kappaB-independent pathway
    Mahmood Akhtar
    Intestinal Disease Research Programme, McMaster University, HSC 3N5C, 1200 Main St West, Hamilton, Ontario, Canada L8N 3Z5
    FASEB J 17:1319-21. 2003
    ..coli DNA exposure. Thus model gut epithelia express TLR-9 mRNA and, while maintaining their barrier function, can respond to E. coli DNA by increased IL-8 production...
  55. pmc Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway
    David Maldonado-Pérez
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh EH16 4TJ, UK
    Biochim Biophys Acta 1793:1315-24. 2009
    ..Our findings show that in endometrial cells PROK1 can activate the calcineurin/NFAT pathway to induce IL-8 expression and that this is negatively modulated by the induction of expression of RCAN1-4...
  56. ncbi Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    M T Abreu
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, 8631 West 3rd Street, Los Angeles, CA 90048, USA
    J Immunol 167:1609-16. 2001
    ..We conclude that IEC limit dysregulated LPS signaling by down-regulating expression of MD-2 and TLR4. The remainder of the intracellular LPS signaling pathway is functionally intact...
  57. pmc Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition
    Andrea Gojova
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, Davis, California, USA
    Environ Health Perspect 115:403-9. 2007
    ..Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothelium...
  58. pmc Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
    Dai Shida
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0614, USA
    Cancer Res 68:6569-77. 2008
    ....
  59. pmc Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8
    A Walz
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 174:1355-62. 1991
    ..Cross-desensitization experiments indicate that ENA-78 acts through the same type of receptors as IL-8, NAP-2, and GRO alpha...
  60. ncbi The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor
    S K Ahuja
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:20545-50. 1996
    ..These findings have important implications for developing novel neutrophil-specific anti-inflammatory drugs directed against the CXC chemokine signaling system...
  61. ncbi A promoter recruitment mechanism for tumor necrosis factor-alpha-induced interleukin-8 transcription in type II pulmonary epithelial cells. Dependence on nuclear abundance of Rel A, NF-kappaB1, and c-Rel transcription factors
    A R Brasier
    Department of Medicine and Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Biol Chem 273:3551-61. 1998
    ....
  62. ncbi Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation
    S Hashimoto
    First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Respir Crit Care Med 161:280-5. 2000
    ..the present study, we therefore examined the role of p38 mitogen-activated protein (MAP) kinase in DEP-induced interleukin 8 (IL-8) and RANTES production by human bronchial epithelial cells (BECs) in order to clarify the intracellular ..
  63. ncbi Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)
    T C Dawson
    Department of Pathology, University of North Carolina, Chapel Hill, NC, USA
    Blood 96:1681-4. 2000
    ..These results suggest that DARC modulates the intensity of inflammatory reactions as a sink for chemokines. (Blood. 2000;96:1681-1684)..
  64. pmc The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
    R M Nissen
    Departments of Cellular and Molecular Pharmacology, and Biochemistry and Biophysics, PIBS Biochemistry and Molecular Biology Program, University of California, San Francisco, San Francisco, California 94143 0450, USA
    Genes Dev 14:2314-29. 2000
    ..Remarkably, GR did not inhibit PIC assembly under repressing conditions, but rather interfered with phosphorylation of serine 2 of the pol II CTD...
  65. ncbi Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia
    J Musial
    Department of Medicine, Jagiellonian University School of Medicine, Skawinska 8, 31 066, Krakow, Poland
    Int J Cardiol 77:247-53. 2001
    ..The aim of the study was to assess the influence of simvastatin and aspirin on serum levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in hypercholesterolemic subjects...
  66. ncbi IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    Aihua Li
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 170:3369-76. 2003
    ..Our data suggest that IL-8 directly enhanced endothelial cell proliferation, survival, and MMP expression in CXCR1- and CXCR2-expressing endothelial cells and regulated angiogenesis...
  67. ncbi In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
    Jean Christophe Bambou
    INSERM, EMI 0212, 156 rue de Vaugirard, 75015 Paris, France
    J Biol Chem 279:42984-92. 2004
    ..These findings provide strong evidence that flagellin released by flagellated commensal bacteria in the intestinal lumen can induce a pro-inflammatory response in enterocytes in vivo...
  68. ncbi Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation
    Kirsten Peters
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    J Mater Sci Mater Med 15:321-5. 2004
    ..If a pro-inflammatory stimulation of endothelial cells occurs in vivo, a chronic inflammation could be a possible consequence...
  69. pmc Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls
    K E Lyke
    Center for Vaccine Development, The University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 72:5630-7. 2004
    ..Hyperparasitemia was associated with significantly lower levels of IL-6 (336.6 versus 602.1; P = 0.002). These results illustrate the complex relationships between inflammatory cytokines and disease in P. falciparum malaria...
  70. ncbi Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract
    J V Fahey
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Reprod 20:1439-46. 2005
    ..Mucosal epithelial cells are capable of producing these factors that communicate with cells of the innate and adaptive immune systems...
  71. ncbi Differences in airway cytokine profile in severe asthma compared to moderate asthma
    Joanne Shannon
    Montreal Chest Institute, Respiratory Division of McGill University Health Centre, Montreal, QC, Canada
    Chest 133:420-6. 2008
    ....
  72. ncbi Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors
    Tohru Kikuchi
    Department of Respiratory Oncology and Molecular Medicine, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Antimicrob Chemother 49:745-55. 2002
    ..In addition to treatment of airway diseases, the anti-inflammatory effect of macrolides may be beneficial for the treatment of other inflammatory diseases such as chronic gastritis caused by H. pylori...
  73. ncbi Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis
    Paul Proost
    Laboratory of Molecular Immunology, Rega Institute, K U Leuven, Leuven, Belgium
    Eur J Immunol 33:3146-53. 2003
    ....
  74. ncbi Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes
    Christina C Hessle
    Department of Clinical Bacteriology, Goteborg University, Guldhedsgatan 10, SE 413 46 Goteborg, Sweden
    Cytokine 30:311-8. 2005
    ..The different cytokine profiles evoked by Gram-positive and Gram-negative bacteria might optimize clearance of bacteria that differ in cell wall structure...
  75. pmc Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
    Ruth E MacRedmond
    Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Respir Res 8:84. 2007
    ..Modulation of TLR4 in respiratory epithelium may have important implications for airway inflammation and infection in response to inhaled pathogens...
  76. ncbi Three-dimensional structure of interleukin 8 in solution
    G M Clore
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Biochemistry 29:1689-96. 1990
    The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-dynamical simulated annealing calculations...
  77. pmc Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Immunol 180:5017-27. 2008
    ..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
  78. pmc Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation
    E F Foxman
    Laboratory of Immunology and Vascular Biology, Stanford University Medical School, Stanford, California 94305, USA
    J Cell Biol 147:577-88. 1999
    ....
  79. ncbi Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Lett 241:221-7. 2006
    ....
  80. ncbi Interleukin-8 in the human endometrium
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 83:1783-7. 1998
    ..We speculate that IL-8 may modulate the timely recruitment of neutrophils and lymphocytes into the endometrium...
  81. pmc Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells
    T S Steiner
    Division of Geographic and International Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    J Clin Invest 105:1769-77. 2000
    ..Furthermore, they open new approaches for diagnosis and vaccine development. This novel pathogenic mechanism of EAEC extends an emerging paradigm of bacterial flagella as inflammatory stimuli...
  82. pmc Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration
    G Godaly
    Department of Medical Microbiology, Lund University, Sweden
    Infect Immun 65:3451-6. 1997
    ..These results demonstrate that IL-8 plays a key role in E. coli- or IL-1alpha-induced transuroepithelial migration and suggest that epithelial cell-produced IL-8 interacts with IL-8RA on the neutrophil surface...
  83. ncbi Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis
    Yi Ren
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong Medical Centre, Hong Kong SAR, China
    Clin Cancer Res 9:5996-6001. 2003
    ..In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate its correlation with clinicopathological features and prognosis...
  84. ncbi Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor
    Bernd Schmeck
    Department of Internal Medicine Infectious Diseases, Charite, University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Biol Chem 279:53241-7. 2004
    ..Thus, p38 MAPK contributes to pneumococci-induced chemokine transcription by modulating p65 NF-kappaB-mediated transactivation...
  85. ncbi Concentrations of macrophage inflammatory proteins MIP-1alpha and MIP-1beta and interleukin 8 (il-8) in lyme borreliosis
    S Grygorczuk
    Dept of Infectious Diseases and Neuroinfections, Medical University of Białystok, ul Zurawia 14, P 15 540 Białystok, Poland
    Infection 32:350-5. 2004
    ..Our aim was to confirm that the synthesis of chemokines is increased in Lyme borreliosis and that they may account for leukocyte migration, thus being involved in inflammatory response...
  86. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ....
  87. pmc Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells
    Mark M Perry
    Biopharmaceutics Research Group, Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Immunol 180:5689-98. 2008
    ..Overall, these studies indicate that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response...
  88. doi Immune mediators in idiopathic nephrotic syndrome: evidence for a relation between interleukin 8 and proteinuria
    Marcelo F O Souto
    Departamento de Pediatria, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130 100, Brazil
    Pediatr Res 64:637-42. 2008
    ..Our findings suggest that IL-8/CXCL8 and TGF-beta1 are involved in the pathogenesis of INS: IL-8/CXCL8 associated with local changes in glomerular permeability and TGF-beta1 could be related to worse response to corticosteroids...
  89. ncbi Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8
    P G Gibson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Chest 119:1329-36. 2001
    ..To identify the characteristics of airway inflammation in persistent asthma and to examine the role of neutrophilic inflammation in noneosinophilic persistent asthma...
  90. ncbi Elevation of cytokine levels in cachectic patients with prostate carcinoma
    Jesco Pfitzenmaier
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    Cancer 97:1211-6. 2003
    ..The objective of the current study was to determine whether cachexia associated with advanced CaP is accompanied by increased serum levels of TNFalpha, IL-1beta, IL-6, and IL-8...
  91. pmc TLR2-mediated cell stimulation in bacterial vaginosis
    Debra Mares
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Reprod Immunol 77:91-9. 2008
    ..Thus, these studies show that soluble factor(s) present in the lower genital tract of women with BV activate cells via TLR2, identifying a pathway through which BV may mediate adverse effects...
  92. ncbi Ultraviolet-B irradiation enhances melanoma cell motility via induction of autocrine interleukin 8 secretion
    Carl Gebhardt
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    Exp Dermatol 16:636-43. 2007
    ..As interleukin 8 (IL-8) is known to be up-regulated by different cell types after UV-B irradiation, we investigated IL-8 ..
  93. ncbi Mode of action of long-term low-dose macrolide therapy for chronic sinusitis in the light of neutrophil recruitment
    Hideaki Suzuki
    Department of Otolaryngology, Sendai National Hospital, Sendai, Japan
    Curr Drug Targets Inflamm Allergy 1:117-26. 2002
    ..In addition, the possible risk of this therapy such as the occurrence of resistant strains have to be carefully surveyed hereafter...
  94. doi Reduction in Staphylococcus aureus growth and exotoxin production and in vaginal interleukin 8 levels due to glycerol monolaurate in tampons
    Kristi L Strandberg
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Infect Dis 49:1711-7. 2009
    ..The purpose of this study was to determine whether GML, as a tampon fiber finish, inhibits production of exotoxins and the cytokine interleukin 8 (IL-8) during normal tampon use.
  95. ncbi Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8
    N Mukaida
    Division of Cancer Treatment, National Cancer Institute, Frederick Cancer Research Facility, MD 21701 1013
    J Immunol 143:1366-71. 1989
    ....
  96. ncbi Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials
    A Li
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198-7660, USA
    Clin Cancer Res 7:3298-304. 2001
    PURPOSE: In the present study, we examined the expression of a multifunctional cytokine, interleukin 8 (IL-8), and its receptors, CXCR1 and CXCR2, in human colon carcinoma cells with different metastatic potentials and determined their ..
  97. pmc Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms
    Matthias Selbach
    Abteilung Molekulare Biologie, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Infect Immun 70:665-71. 2002
    ..The function of VirD4 as a possible adapter protein which guides CagA into the type IV secretion channel is presented in a model...
  98. ncbi Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    Michael Yeh
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 279:30175-81. 2004
    ..induce endothelial cells to synthesize chemotactic factors, such as interleukin 8 (IL-8)...
  99. ncbi Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line
    Hu Shan Cui
    Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Ophthalmic Res 38:149-57. 2006
    ..of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (..
  100. ncbi Chemokine induction by the adipocyte-derived cytokine adiponectin
    Brad H Rovin
    The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Clin Immunol 120:99-105. 2006
    ..We conclude that adiponectin may have pro- and anti-inflammatory effects, and its exact role in specific inflammatory diseases remains to be worked out...
  101. pmc Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8
    Cheng Dong
    Mol Cell Biomech 2:145-59. 2005
    ....

Research Grants64

  1. BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILS
    Mimi Takami; Fiscal Year: 2003
    ..And, as a biological model, we will explore the way in which exposure to Helicobacter pylori, may impact these signals and affect neutrophil adhesion and migration on epithelial surfaces. ..
  2. Emilio B Gonzalez; Fiscal Year: 2014
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  3. Jonathan Savitz; Fiscal Year: 2016
    ....
  4. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ....
  5. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..disease severity and duration of disease recovery focusing on innate immune responsiveness (immunoparalysis), Interleukin 8 (a predictor of outcome for sepsis and acute lung injury), Vitamin D, and SP-A and SP-D (important for lung ..
  6. Georgios I Papachristou; Fiscal Year: 2014
    ..e. tumor necrosis factor-a inhibitors. ..
  7. Toby C Lewis; Fiscal Year: 2014
    ..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
  8. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..abstract_text> ..
  9. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
    ..This DBM-led partnership seeks to lead a new renaissance in complementary and alternative medicine (CAM) research for new global anti-inflammatory drugs with this long-term and closely held scientific and commercial vision. ..
  10. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010
    ..The elucidation of the molecular mechanism(s) of action of genistein will provide clinically related strategies in protecting against atherosclerotic vascular disease. ..
  11. IL8-induced Post-transcriptional Regulation of the MUC5AC mucin gene
    Mary C Rose; Fiscal Year: 2010
    ..This will be fundamental for formulating therapeutic interventions for lung diseases that manifest with mucin overproduction. ..
  12. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors. ..
  13. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2012
    ....
  14. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2013
    ....
  15. William H St Clair; Fiscal Year: 2015
    ..levels;2) suppression of RelB in androgen independent-aggressive prostate cancer cells results in reduction of interleukin 8 (IL8) levels in tumor cells and reduced tumor growth in vivo;3) overexpression of RelB in androgen responsive ..
  16. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..The results of this research will potentially lead us to develop novel, natural, and cost-effective agents to prevent and treat atherosclerosis caused by diabetes, a chronic disease that affects over 23 million Americans. ..
  17. Non-invasive Assessment of Tissue Engineered Human Oral Mucosa
    Mary Ann Mycek; Fiscal Year: 2012
    ..hBD-1), (an innate antimicrobial), and pro-angiogenic cytokines vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8)...
  18. Nader Shaikh; Fiscal Year: 2015
    ..C-reactive protein, polymorphonuclear cell count, erythrocyte sedimentation rate, interleukin 6, interleukin 8, macrophage migration inhibitory factor, interleukin 12, transforming growth factor 21) to develop a ..
  19. Jamie L Renbarger; Fiscal Year: 2016
    ..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
  20. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. ..
  21. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  22. Weibel - Palade Bodies - Sentinels of Acute Ischemia
    Michael S Goligorsky; Fiscal Year: 2013
    ....
  23. The role of polyamine oxidase in antitumor drug response
    Robert A Casero; Fiscal Year: 2013
    ..abstract_text> ..
  24. Bruce P Barrett; Fiscal Year: 2016
    ..Generalized estimating equations, random-effects pattern-mixture models, and hierarchical linear models will be used to assess longitudinal effects, interactions, and covariate mediation. ..
  25. Interleukin-8 Regulation by Proteasome and Nuclear IkB in Cancer and Inflammation
    Ivana Vancurova; Fiscal Year: 2013
    ..In addition, this project will enhance the research environment at St. John's University by providing motivated underprivileged students with numerous opportunities to learn the fundamentals of biomedical research. ..
  26. Imad Shureiqi; Fiscal Year: 2014
    ..Confirmation of the tested hypothesis could lead to developing PPAR-d-targeted therapy to inhibit tumorigenesis. ..
  27. Stanley J Opella; Fiscal Year: 2014
    ..D. MRT has the technology for the expression, purification, and refolding of biologically active GPCRs developed originally by Hans Kiefer, Ph.D., at M-Fold Biotech and he remains involved in the research. ..
  28. Binh An Diep; Fiscal Year: 2014
    ..To test this hypothesis, we will determine whether blocking interleukin 8, the principal chemokine that recruits PMNs into the lung, attenuates PVL-induced acute lung injury and lung ..
  29. Characterization of Anthrax Lethal Toxin
    JEREMY S MOGRIDGE; Fiscal Year: 2010
    ..A better understanding of how the toxin works will help doctors treat patients with anthrax and help researchers discover new drug treatments. ..
  30. Yiu Fai Chen; Fiscal Year: 2016
    ..In addition, it is expected that the results wll fundamentally advance the field of cell-based therapy by providing a noninvasive and cost effective treatment modality. ..
  31. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
    ....
  32. Molecular Markers of Risk, Phenotype, and Outcomes in ARDS
    Ednan K Bajwa; Fiscal Year: 2012
    ..Identifying patients at highest risk of developing ARDS or having adverse outcomes is critical to improving understanding of this disease and developing effective treatments. ..
  33. Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis
    JENNIFER LYNN JOHNS; Fiscal Year: 2011
    ..Five years of mentored support is requested. ..
  34. Nicholas F Larusso; Fiscal Year: 2016
    ....
  35. JENNIFER LYNN JOHNS; Fiscal Year: 2015
    ..Five years of mentored support is requested. ..
  36. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona-Santos; Fiscal Year: 2011
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  37. The Role of DEK in the Development of Arthritis
    Nirit Mor Vaknin; Fiscal Year: 2011
    ..These insights are very important to our ability to develop a new strategy to the diagnosis/treatment of JIA, and to improve the present and future health of children with arthritis and related diseases. ..
  38. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  39. Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    David Rowley; Fiscal Year: 2009
    ..The long-range goal of this work is to develop a novel therapeutic strategy that targets components of the IL-8 / CXCR2 regulatory pathway for the treatment of BPH. ..
  40. Alison K Criss; Fiscal Year: 2016
    ..Taken together, the results from this application will reveal the diverse approaches used by Gc to survive in the presence of antimicrobial PMNs, which ensures the continued persistence of gonorrhea within the human population. ..
  41. Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    David R Rowley; Fiscal Year: 2013
    ..This project will provide data on key mechanisms and pathways using several model systems. These mechanisms and pathways may evolve as therapeutic targets. ..
  42. Bryan R Haugen; Fiscal Year: 2015
    ..define the NFkB-dependent secretome in advanced thyroid cancer, (3) Genetic and functional manipulation of interleukin 8, identified as an important NFkB-dependent secreted protein in thyroid cancer, and other identified NFkB ..
  43. Characterization of Innate immune receptors
    Detlef Schuppan; Fiscal Year: 2009
    ..in human dendritic but also intestinal epithelial cells, as assessed by release of the inflammatory mediators interleukin 8 and MCP-1. Based on these data we plan to: 1...
  44. STAT3 REGULATION OF GLIOBLASTOMA PATHOGENESIS
    Azad Bonni; Fiscal Year: 2013
    ..The proposed studies should also lay the foundation for potential identification of novel therapeutic strategies in patient-tailored treatment of glioblastoma. ..
  45. EMINA HUI NA HUANG; Fiscal Year: 2014
    ..abstract_text> ..
  46. Fernando D Martinez; Fiscal Year: 2015
    ..abstract_text> ..
  47. LOUIS JUSTINE VUGA; Fiscal Year: 2014
    ....
  48. MECHANISM OF ACTION OF TUMOR SUPPRESSOR Tid1
    Jiing Dwan Lee; Fiscal Year: 2010
    ....
  49. X-RAYS INDUCE EXOCYTOSIS OF ENDOTHELIAL P-SELECTIN
    Dennis Hallahan; Fiscal Year: 2002
    ..We will study the roles of calcium and calmodulin in the activation of motor proteins that are required for microtubule- dependent translocation of WPB to the cell membrane. ..
  50. Development of therapeutic monoclonal antibody to the bioactive lipid lysophospha
    Rosalia Matteo; Fiscal Year: 2009
    ..Discovering the major determinants in cancer progression for the development of more efficacious therapies is therefore extremely important to society. ..
  51. EMINA HUI NA HUANG; Fiscal Year: 2016
    ..The proposed research is significant as it will greatly expand our understanding of how IL8 contributes to colitis-associated cancer. ..
  52. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    ..These proposed studies will provide important and novel information regarding the cellular and molecular mechanisms that chemokines use to induce, maintain, and suppress mucosal inflammation and angiogenesis. ..
  53. James L M Ferrara; Fiscal Year: 2014
    ..This algorithm will include both responses to treatment on day 28 after initiation of treatment as well as mortality at day 180 from the initiation of treatment. ..
  54. BYSTANDER EFFECTS OF LOW DOSE ALPHA PARTICLES
    Bruce Lehnert; Fiscal Year: 2001
    ..abstract_text> ..
  55. REGULATION OF HUMAN INTERLEUKIN-8 RECEPTORS
    MICHELER RICHARDSON; Fiscal Year: 2000
    ..These studies will also identify specific targets for the development of therapeutic drugs for the modulation of inflammation. ..
  56. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    ..The proposed study fulfills the scope of the NIAID small research grants program as a small, self-contained research project requiring minimal funding for a limited time. ..
  57. Ventilator-Induced Lung Injury in Children
    Sabrina Heidemann; Fiscal Year: 2004
    ..The results of this study may serve as the basis for a multicenter clinical trial. ..
  58. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2005
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  59. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2004
    ..abstract_text> ..
  60. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2004
    ..A mechanistic understanding of the molecular interplay between IL-8, GRO-alpha, and their receptors could lead to the development of new approaches to the treatment of HIV-infected patients. ..
  61. PROSTAGLANDIN THERAPY FOR ALCOHOLIC HEPATITIS
    Daniell Hill; Fiscal Year: 2004
    ..abstract_text> ..
  62. Biobehavioral-Cytokine Interactions in Ovarian Cancer
    Susan Lutgendorf; Fiscal Year: 2007
    ..Findings will have implications for innovative behavioral and pharmacological intervention strategies for ovarian cancer patients. ..
  63. SURFACTANT PROTEINS AND LUNG INFLAMMATION
    Kelly Greene; Fiscal Year: 2000
    ..These studies combine clinically oriented studies in patients with ARDS with basic studies of new mechanisms by which surfactant proteins may modulate inflammation in the lung. ..