Summary: Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.

Top Publications

  1. ncbi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
  2. ncbi Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  3. pmc Inflammation and cancer
    Lisa M Coussens
    Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
    Nature 420:860-7. 2002
  4. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
  5. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
  6. ncbi The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  7. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
  8. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
  9. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
  10. pmc Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    Chia Lin Tsou
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
    J Clin Invest 117:902-9. 2007

Detail Information

Publications373 found, 100 shown here

  1. ncbi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    ..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
  2. ncbi Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  3. pmc Inflammation and cancer
    Lisa M Coussens
    Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
    Nature 420:860-7. 2002
    ..tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis...
  4. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
    ..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
  5. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
  6. ncbi The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  7. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
    ..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
  8. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  9. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
  10. pmc Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    Chia Lin Tsou
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
    J Clin Invest 117:902-9. 2007
    ..These findings provide evidence that CCR2 and MCP-3/MCP-1 are critical for monocyte mobilization and suggest new roles for monocyte chemoattractants in leukocyte homeostasis...
  11. pmc Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids
    Valerie Wittamer
    Institut de Recherche en Biologie Humaine et Moléculaire, ULB Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    J Exp Med 198:977-85. 2003
    ..Therefore, chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs...
  12. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  13. pmc Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
    Keisuke Nagao
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Nat Immunol 13:744-52. 2012
    ..Pre-LCs failed to enter hairless skin in mice or humans, which establishes hair follicles as portals for LCs...
  14. ncbi Chemokines: multiple levels of leukocyte migration control
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Trends Immunol 25:75-84. 2004
    The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to leukocyte traffic...
  15. pmc Role of chemokines in tumor growth
    Dayanidhi Raman
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Lett 256:137-65. 2007
    b>Chemokines play a paramount role in the tumor progression. Chronic inflammation promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and cytokines...
  16. pmc Chemokines and chemokine receptors: new insights into cancer-related inflammation
    Gwendal Lazennec
    INSERM, U844, Site Saint Eloi Bâtiment INM 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F 34090, France
    Trends Mol Med 16:133-44. 2010
    b>Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation...
  17. pmc Chemokines in health and disease
    Dayanidhi Raman
    Department of Cancer Biology, Vanderbilt University, School of Medicine, USA
    Exp Cell Res 317:575-89. 2011
    b>Chemokines and their receptors play a key role in development and homeostasis as well as in the pathogenesis of tumors and autoimmune diseases...
  18. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
    ..and detrimental role in vivo after I/R injury, as reflected by a reduction in the amount of local cytokines and chemokines, leukocytes, and the level of renal injury and dysfunction in TLR2-/- mice compared with controls...
  19. ncbi Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
    Kerry B Goralski
    Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 282:28175-88. 2007
    ..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
  20. ncbi A question of self-preservation: immunopathology in influenza virus infection
    Nicole L La Gruta
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 85:85-92. 2007
  21. ncbi Immunology of tuberculosis
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Immunol 19:93-129. 2001
    ..the induction, specificity, and effector functions of CD4(+) and CD8(+) T cells, and the roles of cytokines and chemokines in the induction and effector functions of the immune response...
  22. ncbi Chemokines and disease
    C Gerard
    Department of Pediatrics, Perlmutter Laboratory, Children s Hospital, Boston, MA, USA
    Nat Immunol 2:108-15. 2001
    ..Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed...
  23. ncbi Functional classification of interferon-stimulated genes identified using microarrays
    M J de Veer
    Department of Cancer Biology, Lerner Research Institute, Cleveland, Ohio, USA
    J Leukoc Biol 69:912-20. 2001
  24. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
    ..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
  25. ncbi Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion
    Yukihiko Suzuki
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, Aomori, 036 8562, Japan
    Jpn J Ophthalmol 55:256-63. 2011
    The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO)...
  26. ncbi Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells
    Antal Rot
    Novartis Institute for Biomedical Research, Vienna, A 1235 Austria
    Annu Rev Immunol 22:891-928. 2004
    b>Chemokines compose a sophisticated communication system used by all our cell types, including immune cells...
  27. ncbi The role of chemokine receptors in primary, effector, and memory immune responses
    F Sallusto
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Annu Rev Immunol 18:593-620. 2000
    ..There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic ..
  28. ncbi Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis
    Heidi Kokkonen
    Umea University Hospital, Umea, Sweden
    Arthritis Rheum 62:383-91. 2010
    To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA).
  29. ncbi Chemokine receptors and their role in inflammation and infectious diseases
    C Murdoch
    Division of Child Health, University of Sheffield, Sheffield Children s Hospital, Sheffield, United Kingdom
    Blood 95:3032-43. 2000
    b>Chemokines are small peptides that are potent activators and chemoattractants for leukocyte subpopulations and some nonhemopoietic cells...
  30. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
    ..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
  31. ncbi Chemokines in cutaneous wound healing
    R Gillitzer
    Department of Dermatology, University of Wurzburg Medical School, Germany
    J Leukoc Biol 69:513-21. 2001
    ..Recent data demonstrate that recruitment of leukocyte subtypes is tightly regulated by chemokines. Moreover, the presence of chemokine receptors on resident cells (e.g...
  32. ncbi Lymphocyte traffic control by chemokines
    B Moser
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    Nat Immunol 2:123-8. 2001
    ..discovery that peripheral blood T cells need to be activated before they can migrate in response to inflammatory chemokines. These chemokines do not act on the bulk of resting T cells that are in circulation...
  33. pmc Role of cytokines and chemokines in non-alcoholic fatty liver disease
    Vincent Braunersreuther
    Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Geneva University Hospital, 1211 Geneva, Switzerland
    World J Gastroenterol 18:727-35. 2012
    ..Among several mediators, cytokines and chemokines might play a pivotal active role in NAFLD and are considered as potential therapeutic targets...
  34. pmc Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
    O Meucci
    Department of Pharmacological and Physiological Sciences, University of Chicago, 947 E 58th Street MC 0926, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 95:14500-5. 1998
    ..Fura-2-based Ca imaging showed that numerous chemokines, including SDF-1alpha, RANTES, and fractalkine, affect neuronal Ca signaling, suggesting that hippocampal ..
  35. ncbi Chemerin is a novel adipokine associated with obesity and metabolic syndrome
    Kiymet Bozaoglu
    Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
    Endocrinology 148:4687-94. 2007
    ..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
  36. pmc Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks
    Bridgette D Semple
    National Trauma Research Institute, Alfred Health, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:459-73. 2010
    b>Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of particular interest in the context of the unique immune responses elicited in the central nervous system (CNS)...
  37. ncbi Structure, function, and inhibition of chemokines
    Elias J Fernandez
    Department of Pharmacology, Yale University, New Haven, Connecticut 06520 8066, USA
    Annu Rev Pharmacol Toxicol 42:469-99. 2002
    b>Chemokines are the largest family of cytokines in human immunophysiology...
  38. ncbi Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury
    Jenna M Ziebell
    National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, VIC 3181, Australia
    Neurotherapeutics 7:22-30. 2010
    ..This review addresses the role of several cytokines and chemokines following focal and diffuse TBI, as well as the controversies around the use of therapeutic anti-inflammatory ..
  39. ncbi Chemokines and their receptors: drug targets in immunity and inflammation
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Annu Rev Pharmacol Toxicol 48:171-97. 2008
    ..Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics...
  40. ncbi Chemokines in liver inflammation and fibrosis
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, RWTH Aachen, Germany
    Semin Liver Dis 30:215-25. 2010
    b>Chemokines are a class of small chemotactic molecules with cytokine-like functions, which are well known to orchestrate inflammatory responses within different organs. Overall, more than 50 ligands and 19 receptors belong to the network...
  41. ncbi Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases
    Laetitia Cartier
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Brain Res Rev 48:16-42. 2005
    b>Chemokines were originally described as chemotactic cytokines involved in leukocyte trafficking. Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes...
  42. ncbi The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities
    Adriana López Ponte
    Laboratoire d Hématopoïèse, Institut National de la Santé et de la Recherche Médicale ER15, IFR135 Université François Rebelais, Tours, France
    Stem Cells 25:1737-45. 2007
    ..1beta (IL1beta) and tumor necrosis factor alpha (TNFalpha), in response to 16 growth factors (GFs) and chemokines. We show that BM MSCs migrate in response to many chemotactic factors...
  43. pmc Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis
    Pradeep Tyagi
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Urol 187:2243-8. 2012
    Based on basic research findings an increase in chemokines and cytokines (CXCL-1 and 10, nerve growth factor and interleukin-6) is considered responsible for inflammation and afferent sensitization...
  44. pmc Monocyte-endothelial cell interactions in the development of atherosclerosis
    Javier Mestas
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 18:228-32. 2008
    ..lesion-prone sites in the arterial tree results in the up-regulation of cell adhesion molecules and chemokines, which mediate the recruitment of circulating monocytes...
  45. ncbi Orchestrating the orchestrators: chemokines in control of T cell traffic
    Shannon K Bromley
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:970-80. 2008
    The understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors have been identified...
  46. ncbi TREMs in the immune system and beyond
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 3:445-53. 2003
    ..TREM1 triggers phagocyte secretion of pro-inflammatory chemokines and cytokines, amplifying the inflammation that is induced by bacteria and fungi...
  47. ncbi Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking
    Maria Jesus Sanz
    Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    Eur J Immunol 42:278-83. 2012
    b>Chemokines are proinflammatory mediators that regulate leukocyte trafficking at different steps of the leukocyte recruitment cascade...
  48. ncbi Chemokines in CNS injury and repair
    Anne Jaerve
    Molecular Neurobiology Laboratory, Department of Neurology, Medical Faculty Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Cell Tissue Res 349:229-48. 2012
    ..Cell activation and infiltration to the injury site is orchestrated by changes in the expression of chemokines, the chemoattractive cytokines...
  49. ncbi The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008
    ..leukocyte infiltration; the expression of cytokines such as tumor necrosis factor (TNF) or interleukin (IL)-1; chemokines such as CCL2 and CXCL8; active tissue remodelling and neo-angiogenesis...
  50. ncbi Experimental stroke induces massive, rapid activation of the peripheral immune system
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:654-65. 2006
    ..We quantified mRNA and protein levels for cytokines, chemokines, and chemokine receptors (CCR) in brain, spinal cord, peripheral lymphoid organs (spleen, lymph node, blood, and ..
  51. pmc Rapid expression of chemokines and proinflammatory cytokines in newly hatched chickens infected with Salmonella enterica serovar typhimurium
    G S K Withanage
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Infect Immun 72:2152-9. 2004
    ..the spleens of the infected birds show little or no change in the expression levels of these cytokines and chemokines. Increased expression of the proinflammatory cytokines and chemokines (up to several hundred-fold) correlated ..
  52. ncbi Molecular pathways linking inflammation and cancer
    A Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Mol Med 10:369-73. 2010
    ..Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  53. ncbi Chemokines in liver inflammation and fibrosis
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Italy
    Front Biosci 7:d1899-914. 2002
    b>Chemokines may be involved in the tissue response to injury regulating the influx of leukocytes, and modulating a number of other critical biologic actions, including angiogenesis, neoplastic growth, myo-fibroblast activation, and the ..
  54. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ..We show that the functional responses of freshly isolated human and murine neutrophils to CXCR2 chemokines are significantly attenuated by SDF-1alpha, acting via CXCR4...
  55. ncbi Chemokine: receptor structure, interactions, and antagonism
    Samantha J Allen
    Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, California 92093, USA
    Annu Rev Immunol 25:787-820. 2007
    b>Chemokines are critical mediators of cell migration during routine immune surveillance, inflammation, and development...
  56. ncbi Cancer and the chemokine network
    Fran Balkwill
    Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s Medical School, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Cancer 4:540-50. 2004
  57. ncbi Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system
    William Rostene
    Institut de la Vision UMRS INSERM UPMC 968, Paris, France
    J Neurochem 118:680-94. 2011
    Recent observations suggest that besides their role in the immune system, chemokines have important functions in the brain...
  58. ncbi Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    M Romano
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Immunity 6:315-25. 1997 a reduced migratory capacity of IL-6-/- leukocytes and was associated with a reduced in situ production of chemokines. These observations led to a reexamination of the interaction of IL-6 with endothelial cells (EC)...
  59. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  60. pmc Chemokines and the pathophysiology of neuropathic pain
    Fletcher A White
    Department of Cell Biology, Loyola University Chicago, Maywood, IL 60626, USA
    Proc Natl Acad Sci U S A 104:20151-8. 2007
    b>Chemokines and chemokine receptors are widely expressed by cells of the immune and nervous systems. This review focuses on our current knowledge concerning the role of chemokines in the pathophysiology of chronic pain syndromes...
  61. pmc Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology
    Richard M Ransohoff
    Neuroinflammation Research Center Lerner Research Institute and Mellen Center for MS Treatment and Research Neurological Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 31:711-21. 2009
    There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology...
  62. ncbi Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    Tsvee Lapidot
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Exp Hematol 30:973-81. 2002
    ..experimental animal models and samples from clinical mobilization protocols demonstrate major involvement of chemokines such as stromal derived factor-1 (SDF-1) and IL-8, as well as proteolytic enzymes such as elastase, cathepsin G, ..
  63. ncbi Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, King Abdulaziz University Hospital, Airport Road, PO Box 245, Riyadh 11411, Saudi Arabia
    Eur Cytokine Netw 17:155-65. 2006
    To determine levels of the chemokines CCL1/I-309, CCL2/MCP-1, CCL3/MIP-1alpha, CCL4/MIP-1beta, CCL7/MCP-3, CCL8/MCP-2, CXCL5/ENA-78, CXCL6/GCP-2, CXCL10/IP-10, and CXCL11/I-TAC in the vitreous humor and serum, from patients with ..
  64. ncbi Characterization of chemokines and their receptors in the central nervous system: physiopathological implications
    Adriana Bajetto
    Service of Pharmacology and Neuroscience Institute for Cancer Research, Genoa, Italy
    J Neurochem 82:1311-29. 2002
    b>Chemokines represent key factors in the outburst of the immune response, by activating and directing the leukocyte traffic, both in lymphopoiesis and in immune surveillance...
  65. pmc Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    Mika Shimonaka
    Bayer Chair, Dept of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 161:417-27. 2003
    b>Chemokines arrest circulating lymphocytes within the vasculature through the rapid up-regulation of leukocyte integrin adhesive activity, promoting subsequent lymphocyte transmigration...
  66. pmc The chemokine and chemokine receptor superfamilies and their molecular evolution
    Albert Zlotnik
    Neurocrine Biosciences, Inc, Department of Molecular Medicine, 12790 El Camino Real, San Diego, CA 92130, USA
    Genome Biol 7:243. 2006
    ..This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human.
  67. ncbi Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines
    Laura Pelosi
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Via A Scarpa, 14 Rome 00161, Italy
    FASEB J 21:1393-402. 2007
    ..such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and modulated the expression of CC chemokines involved in the recruitment of monocytes/macrophages...
  68. pmc The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques
    Yichuan Wang
    California National Primate Research Center, University of California Davis, Davis, California 95616, USA
    J Virol 79:14355-70. 2005
    ..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
  69. pmc CCR6 as a mediator of immunity in the lung and gut
    Toshihiro Ito
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Exp Cell Res 317:613-9. 2011
    b>Chemokines are key mediators of leukocyte recruitment during pathogenic insult and also play a prominent role in homeostasis...
  70. pmc Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population
    Kiymet Bozaoglu
    Metabolic Research Unit, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3218, Australia
    J Clin Endocrinol Metab 94:3085-8. 2009
    ..Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in a small sample of subjects from Mauritius...
  71. pmc Natural hemozoin stimulates syncytiotrophoblast to secrete chemokines and recruit peripheral blood mononuclear cells
    N W Lucchi
    Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    Placenta 32:579-85. 2011
  72. ncbi The role of chemokines in neutrophil biology
    Yoshiro Kobayashi
    Division of Molecular Medicine, Dept of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan
    Front Biosci 13:2400-7. 2008
    ..Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment...
  73. ncbi Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    Y Pan
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Nature 387:611-7. 1997
    b>Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation...
  74. ncbi Immunologic messenger molecules: cytokines, interferons, and chemokines
    Scott P Commins
    University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:S53-72. 2010
    Cytokines and chemokines are secreted proteins involved in numerous aspects of cell growth, differentiation, and activation...
  75. ncbi Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
    Benjamin Bondue
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Cytokine Growth Factor Rev 22:331-8. 2011
    ..Both chemerin and ChemR23 are also expressed by adipocytes, and the emerging role of chemerin as an adipokine regulating lipid and carbohydrate metabolism is an area of intense research...
  76. ncbi Chemokines in pathology and medicine
    M Baggiolini
    Theodor Kocher Institute, University of Bern, and Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Intern Med 250:91-104. 2001
    About 50 human chemokines and nearly 20 receptors have been identified and characterized in little more than a decade since the discovery of interleukin 8 (IL-8), the first chemotactic cytokine...
  77. ncbi Chemokines: attractive mediators of the immune response
    Mark M Wong
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Semin Immunol 15:5-14. 2003
    ..b>Chemokines are critical in this response since they are both chemotactic and immunoregulatory molecules...
  78. ncbi Closed head injury--an inflammatory disease?
    Oliver I Schmidt
    Department of Trauma and Reconstructive Surgery, Charité University Medical School Berlin, Campus Benjamin Franklin, Germany
    Brain Res Brain Res Rev 48:388-99. 2005
    ..the so far known mechanisms of posttraumatic neuroinflammation after CHI, based on data from clinical and experimental studies, with a special focus on the role of pro-inflammatory cytokines, chemokines, and the complement system.
  79. pmc Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis
    Jaap G Neels
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 284:20692-8. 2009
    ..These studies suggest that KC and its receptor CXCR2 are potential targets for the development of new therapeutic approaches for treatment of obesity-related insulin resistance, type II diabetes, and related cardiovascular diseases...
  80. ncbi Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice
    Niels R Veillard
    Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circ Res 94:253-61. 2004
    ..Recruitment of leukocytes within the vascular wall, controlled by chemokines, is an essential process in the development of this common disease...
  81. ncbi Chemokines in atherosclerosis: an update
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Germany
    Arterioscler Thromb Vasc Biol 28:1897-908. 2008
    The fundamental importance of chemokines for atherogenesis, progression, and destabilization of atherosclerotic plaques is now widely appreciated, but the degree of complexity, specificity, and cooperativity harnessed by these signal ..
  82. ncbi Repair after myocardial infarction, between fantasy and reality: the role of chemokines
    Elisa A Liehn
    Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Aachen, Germany
    J Am Coll Cardiol 58:2357-62. 2011
    ..This review highlights the cellular and molecular processes after myocardial injury and focuses on chemokines, the main modulators of the inflammatory and reparatory events, as the most valuable drug targets.
  83. pmc TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
    J Clin Immunol 31:89-98. 2011
    ..We present the first comprehensive analysis of 24 cytokines, chemokines, and hematopoietic growth factors production by purified human peripheral blood B cells (CD19+), and naive (CD19+..
  84. pmc Effect of anticoagulants on multiplexed measurement of cytokine/chemokines in healthy subjects
    Angelique Biancotto
    Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, MD 28092, USA
    Cytokine 60:438-46. 2012
  85. ncbi The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways
    Hejiang Zhou
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Biomaterials 33:6933-42. 2012
    ..stimulates the secretion of Th1/Th2 cytokines including IL-1α, IL-6, IL-10, TNF-α and GM-CSF as well as chemokines such as MCP-1, MIP-1α, MIP-1β and RANTES, probably by activating TLR-mediated and NF-κB-dependent ..
  86. ncbi Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure
    Pedro E Marques
    Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Hepatology 56:1971-82. 2012
    ..We have previously demonstrated that an intravascular gradient of chemokines and mitochondria-derived formyl peptides collaborate to guide neutrophils to sites of liver necrosis by CXC ..
  87. ncbi Intestinal epithelial cells as a source of inflammatory cytokines and chemokines
    Andrew W Stadnyk
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia
    Can J Gastroenterol 16:241-6. 2002 has the interest in enterocyte production of cytokines with chemoattractant properties for leukocytes - the chemokines. Neutrophils are a prominent feature of the cellular infiltrate in various inflammatory diseases, and early ..
  88. ncbi TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection
    Daniel R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Sydney, New South Wales, Australia
    J Immunol 168:4620-7. 2002
    ..smegmatis was TNF independent, but TNF was required for the early expression of mRNA encoding C-C and C-X-C chemokines and the initial recruitment of CD11b(+) macrophages and CD4(+) T cells to the liver during the second week of ..
  89. pmc Role of chemokines in regulation of immunity against leishmaniasis
    Steve Oghumu
    Department of Pathology, The Ohio State University Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA
    Exp Parasitol 126:389-96. 2010
    ..immunity to Leishmania depends on recruitment of appropriate immune effector cells to the site of infection and chemokines play a crucial role in the process...
  90. pmc Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 207:763-76. 2010
    ..The release of these beta-chemokines explains both the specificity for R5 HIV-1 and the activity of these mAbs in PBMC cultures containing both ..
  91. ncbi Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
    Ana P Campanelli
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Hum Immunol 71:1220-7. 2010
    ..Therefore, different chemokines may affect the predominance of cell infiltration in distinct clinical manifestations...
  92. pmc The blood-brain barrier, chemokines and multiple sclerosis
    David W Holman
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochim Biophys Acta 1812:220-30. 2011
    ..An important step in this cascade is the presence of chemokines on the vascular endothelial cell surface...
  93. pmc Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:1209-16. 2006
    ..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
  94. ncbi Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University Heidelberg, Germany
    Clin Cancer Res 17:678-89. 2011
    ..The contribution of intratumoral cytokines and chemokines in shaping the composition of the inflammatory lymphocytic infiltrate is also unclear.
  95. ncbi Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules
    João B Calixto
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina UFSC, Florianopolis, SC, Brazil
    Planta Med 70:93-103. 2004
    ..PK:protein kinase PMA/TPA:phorbol myristate acetate RANTES:regulated upon activation normal T-cell expressed and secreted TGF-beta:transforming growth factor-beta TNFalpha:tumour necrosis factor VCAM-1:vascular cell adhesion molecule-1..
  96. ncbi The biology of chemokines and their receptors
    D Rossi
    PharMingen Inc, San Diego, California 92121 1111, USA
    Annu Rev Immunol 18:217-42. 2000
    ..of bioinformatics and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors...
  97. ncbi Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis
    Jaspreet Kaur
    Endocrinology and Metabolism Research Group, University of Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
    Biochem Biophys Res Commun 391:1762-8. 2010
    ..01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity...
  98. ncbi Chemokines in the vascular inflammatory response of atherosclerosis
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 86:192-201. 2010
    ..In addition, the progression of atherosclerosis is determined by a disturbed equilibrium of immune responses. Chemokines and their receptors are instrumental in orchestrating the influx of leucocytes to the vascular wall, but also ..
  99. pmc Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines
    Basam Z Barkho
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Stem Cells 26:3139-49. 2008
    ..Here we demonstrate that in response to two injury-induced chemokines, stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor, aNPCs differentiated into ..
  100. pmc Chemokines regulate the migration of neural progenitors to sites of neuroinflammation
    Abdelhak Belmadani
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurosci 26:3182-91. 2006
    ..slice cultures, grafted neural progenitor cells (NPs) migrate toward areas of neuroinflammation and that chemokines are a major regulator of this process...
  101. ncbi Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
    Markus Krumbholz
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Brain 129:200-11. 2006
    ..This study focused on the chemokines CXCL12 (SDF-1) and CXCL13 (BCA-1), both of which regulate B cell migration in lymphoid tissues...

Research Grants77

  1. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013 alpha-1 microglobulin, a marker of tubular injury, and urinary excretion of inflammatory cytokines and C-C chemokines, i.e. markers of renal inflammation...
  2. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..undergoing multiple and differential phosphorylation and dephosphorylation reactions in response to antigen and chemokines. These modifications likely define ezrin's ability to provide a tethering or signaling function depending ..
  3. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..approaches can induce T cell tolerance, they do not impact on the generation of proinflammatory cytokines and chemokines that are induced by conditioning therapy and critical to the development of GVHD...
  4. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..Several serum chemokines correlating with the IFN gene expression signature have been identified...
  5. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..CpG motifs that activate TLR9 and MyD88-dependent signaling pathways resulting in robust production of cyto- and chemokines, which induce strong priming effects and stimulate acquired virus- specific immune responses...
  6. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Our analysis of EC responses to DV infection revealed the high level induction of chemokines that direct immune cell recruitment and activation...
  7. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..Changes in leukocyte recruitment to the nervous system are reflected by specific changes in select chemokines including CXCL1, CXCL10 and CCL2 in the infected tissue...
  8. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..b>Chemokines function through at least three distinct types of interactions: dimerization, extracellular matrix ..
  9. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..In addition to IFN, PDC produce chemokines and tumor necrosis factor-a upon HSV stimulation...
  10. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..This dampens the immune response by reducing the production of pro-inflammatory cytokines and chemokines. IL-10 can also directly protect neurons from apoptosis in models of glutamate excitotoxicity and other stress ..
  11. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..immature MFs and DCs to mature MFs and DCs as well as an array of monocyte/macrophage- and DC-recruiting chemokines. We also found that the direct inhibition of CTB invasion by macrophages was enhanced by conditioned media from ..
  12. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..obesity is associated with chronic inflammation-characterized by increased production and secretion of cytokines/chemokines by adipose tissue (AT) and liver-and with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) ..
  13. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011 alpha-1 microglobulin, a marker of tubular injury, and urinary excretion of inflammatory cytokines and C-C chemokines, i.e. markers of renal inflammation...
  14. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..hours following chlamydial infection was observed as well as a decrease in the production of several important chemokines and cytokines, indicating that substance P may play a role in both the innate and adaptive immune responses in ..
  15. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..of NF-:B mediated transcription, which plays a central role in the expression of inflammatory cytokines, chemokines, adhesion molecules and inflammatory mediators, including matrix metalloproteases...
  16. The Role of Adipocyte-Induced Inflammation in Prostate Tumor Progression
    AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012 the CTSK-expressing bone marrow adipocytes and the adipocyte- driven inflammation involving CXCL1 and CXCL2 chemokines. The project is composed of three specific aims...
  17. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..memory and cognition by a unique combination of mechanisms, comprising the induction of neuroprotective ?-chemokines and neurotrophic NGF. The long-term objectives are to find new potential treatments for HIV-associated dementia...
  18. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013 CaMKK2 null mice that is lethal for WT mice results in a profound decrease in proinflammatory cytokines and chemokines in serum, reduced liver damage and well as markedly prolonged survival...
  19. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..CSF concentrations of tumor necrosis factor-alpha and interleukin-6 and their soluble receptors as well as chemokines such as monocyte chemoattractant protein-1...
  20. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..Pilot data indicate that chemokines which signal DC recruitment are expressed in lower levels in diabetic than control mice early in TB...
  21. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..Several studies in Parp1 KO mice have shown a decreased expression of host inflammatory mediators, cytokines, chemokines, adhesion molecules as well as reduced immune tissue infiltration in various model of inflammation including, ..
  22. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..In both cases, unique chemokines (chemotactic cytokines) produced by the lymphatic endothelium play central roles in driving the respective ..
  23. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..and measure markers of oxidative stress, inflammatory cells in bronchoalveolar lavage and lungs, cytokines and chemokines, and airway hyper- reactivity...
  24. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012 induce ORMDL3 expression in Eos, in Aim 2 we will evaluate regulation of ORMDL3 expression by cytokines and chemokines present at sites of inflammation such as IL-5, GMCSF, IL-13, IL-17, IL-23 and C5a in addition to IL-3 and ..
  25. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2012
    ..Extensive population studies have demonstrated that polymorphisms in host genomes encoding chemokines and their receptors are associated with altered rates of HIV-1 infection and disease progression...
  26. Immune Regulation of Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2012
    ..In situ hybridization combined with confocal microscopy in Aim 1 will determine the spatial relationship between chemokines, viral antigen, ASC localization and the microvasculature...
  27. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..analysis, we showed that the pro- inflammatory cytokine, IL-1[unreadable], as well as the Ccl2, Ccl3, and Ccl7 chemokines, are increased to a greater extent in the brain of the HIV-1Tg rat compared to the F344 control rat...
  28. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..Specific Aim 2 will examine CCR5 involvement in MWCNT granulomas by quantifying CCR5 receptor and chemokines in bronchoalveolar lavage (BAL) derived alveolar macrophages, BAL fluids, and in granulomatous foci isolated by ..
    Devendra K Agrawal; Fiscal Year: 2013
    ..myocardium, and functions as both endocrine organ and inflammatory tissue, secreting hormones, cytokines and chemokines. Since atherosclerotic lesions result from inflammation and extracellular matrix formation that are exaggerated ..
  30. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..Elevated serum concentrations of tumor necrosis factor (TNF) and TNF-inducible proinflammatory cytokines/chemokines, such as IL-8 and IL-18 have been reported in patients with alcoholic hepatitis and/or cirrhosis, and levels ..
    Yoshio Yamaoka; Fiscal Year: 2013
    ..Here, we propose to determine how OipA and the cag PAI induce CXC chemokines using isolated gastric epithelial cells...
  32. ETS-1 and Vascular and Renal Injury in Salt Sensitive Hypertension
    Edgar A Jaimes; Fiscal Year: 2013
    ..been identified as a critical molecule that regulates the vascular expression of a variety of growth factors, chemokines and adhesion molecules...
  33. Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1
    ROBERT MATTHEW TIGHE; Fiscal Year: 2013
    ..CXCR3 is the receptor for the IFNg-inducible chemokines CXCL9 (Mig), CXCL10 (IP-10) and CXCL11 (ITAC)...
  34. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..Upon signaling by chemokines such as MCP1 leukocytes are drawn toward endothelial cells...
  35. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Ig-Fc and the second ecto domain of the CCR5 receptor, hR-421 binds and neutralizes all 3 CCR5-binding ligands (chemokines MIP-?, MIP-?, RANTES) and prevents their binding and activation of CCR1, CCR3, and CCR5...
  36. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..Aim 2: To determine the mechanism of pancreatic production of cytokines, chemokines, and reactive oxygen species in the early stage of ligation-induced acute pancreatitis...
  37. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..cytokine and plays an important role in the pathogenesis of EAE by upregulating the expression of cytokines and chemokines. EAE is markedly suppressed in mice lacking IL-17 or IL-17 receptor...
  38. Immune Mechanisms That Control Ectromelia Virus Infection
    Luis J Sigal; Fiscal Year: 2013
    ..In Aim 2 we will determine the chemokines and chemokine receptors expressed at the site of ECTV infection in resistant or susceptible mice, and the ..
  39. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..survival and repair, and are also responsible for the production of pro-inflammatory molecules (cytokines, chemokines, growth factors, NO etc) growth-inhibitory molecules detrimental to functional recovery...
  40. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..The hypothesis is that oxidants formed from smoke interact the tissues in the airway to cause the release of chemokines the latter activate PMNs by ligation of L-selectin...
  41. Novel Functions of S1P in Neuroinflammation
    TOMASZ K KORDULA; Fiscal Year: 2013
    ..Although IL-1 induces expression of many cytokines via the activation of nuclear factor ?B, induction of several chemokines important for MS and EAE, such as RANTES and IP-10, requires the activation of an additional transcription ..
  42. Counter-Regulation of TLR-Driven Mucosal Inflammation
    Erik P Lillehoj; Fiscal Year: 2010
    ..and flagellin (TLR5) activate signaling pathways leading to the production of proinflammatory cytokines and chemokines and the recruitment of immune effecter cells leading to clearance of the invading microbe...
  43. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..profiles in this cohort of 40 controls and 137 UC patients were defined, there were 13 tissue cytokines and chemokines that were significantly elevated in the UC versus control patients, but out of a panel of 42 analytes, there ..
  44. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    ..However, the standard method for measuring plasma or serum levels of cytokines, chemokines or other biomarkers is to measure them one at a time using Enzyme-Linked Immunosorbent Assay (ELISA)...
  45. Bordetella Cyclase Toxin:Effect on Leukocytes and Respiratory Epithelial Cells
    Erik L Hewlett; Fiscal Year: 2013
    ..of reactive-oxygen species, NET formation and bacterial killing by PMN;and (1C) the production of cytokines/chemokines by PMN in response to B. pertussis and other stimuli...
  46. Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
    Alison Morris; Fiscal Year: 2013
    ..leads to systemic inflammation that has deleterious end-organ effects and will measure peripheral cytokines and chemokines. We will then determine if MT is associated with worse cardiac and pulmonary function and will model association ..
  47. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..Pro-inflammatorycytokines such as tumor necrosisfactor-alpha (TNF) and interleukin-18 (IL-18), and chemokines such as interleukin-8 (IL-8) have been postulated to play a role in mediating manyof the systemic manifestations ..
  48. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..regulating preferential vASC migration into the CNS;3) determine the relative role of CNS localized Ag versus chemokines in regulating ASC retention and 4) demonstrate that BAFF is the major survival factor for ASC within the CNS...
  49. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013
    ..Inhibition of NIK reduces the expression of an array of chemokines with relevance in asthma...
  50. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..Markedly diminished expression of T- and B-cell chemokines (CCL19, 21, CXCL13) and LN stromal cells depletion;4...
  51. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..MCP-1 is a small, secreted protein in the family of C-C chemokines. In the liver, Kupffer cells, hepatic stellate cells, and sinusoidal endothelial cells produce MCP-1, which ..
  52. Developing Novel Serological Biomarkers for Autoimmune Liver Diseases
    Xuhang Li; Fiscal Year: 2013
    ..Cytokines/chemokines, known to play essential roles in the pathogenesis of AILDs, are another potential source of AILD biomarkers...
  53. Characterizaton of Motility Factor Receptor
    Avraham Raz; Fiscal Year: 2012
    ..AMF/PGI contains the CXXC thioredoxin-box motif which resembles the CC and CXC motifs of chemokines and its signaling pathway involves cytoskeletal rearrangement and morphological alteration...
    Stephen W Chensue; Fiscal Year: 2013
    ..We have examined the role of chemoattractant proteins in these responses with the objective to identify critical chemokines and chemokine receptors required for effective and appropriate responses to these pathogens...
  55. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..arthritis (RA) is a chronic inflammatory joint disorder in which activated synovial fibroblasts produce chemokines that facilitate the invasion of the articular cartilage and underlying bone by the release of matrix-degrading ..
    Thomas M Moran; Fiscal Year: 2010
    ..At this point, a sudden rapid generation of chemokines and cytokines that we refer to as the inflammatory burst occurs in the lungs...
  57. Epigenetics of the Aging Astrocyte: Implications for Stroke
    Farida Sohrabji; Fiscal Year: 2013
    ..including a reduced ability to sequester glutamate, decreased growth factor release, increased release of chemokines and increased ability to recruit leukocytes...
  58. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2013
    ..activity of PGP may be due to a marked structural relatedness to a receptor binding domain of ELR+ CXC chemokines such as IL-8 which contain this collagen sequence or a close analog...
  59. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2012
    ..Microglia are an important source of inflammatory mediators, including cytokines, chemokines, and reactive oxygen species, all of which contribute to brain damage...
  60. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010
    ..TNF-alpha-induced production of monocyte chemoattractant protein -1 (MCP-1) and interleukin-8 (IL-8), two chemokines that are the key factors in the firm adhesion of monocytes to activated endothelial cells, (3) TNF-alpha ..
  61. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..Upon stimulation, iNKT cells produce large amounts of T helper 1 (Th1), Th2 cytokines and chemokines in a rapid burst which has a broad immunological influence, including protection against autoimmune diseases, ..
    INDER MOHAN VERMA; Fiscal Year: 2013
    ..are an important modulator of inflammation through their capacity to secrete a variety of proinflammatory chemokines and cytokines...
  63. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..but not non-infected RBC activate BBB endothelium: increase ICAM-1 expression on HBMEC, release cytokines &chemokines and decrease barrier integrity...
    Lili Feng; Fiscal Year: 2000
    ..Recent advances in molecular cloning of cellular chemoattractants called chemokines have opened a new avenue to determine the means by which the body controls the influx of cells...
  65. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2006
    ..Several studies have shown the ability of cytokines and chemokines to facilitate the release of ET-1...
    Philip Osdoby; Fiscal Year: 2002
    ..We have shown that osteoclasts produce small proinflammatory molecules known as chemokines, such as IL-8 and GRO alpha and that such molecules can act to modulate osteoclast precursor recruitment, ..
  67. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..encephalitis, and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and cytokines in the brain...
  68. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..e. CC chemokines MIP-1a, MIP-1[unreadable], and RANTES by the cells...
    Sem H Phan; Fiscal Year: 2010
    ..Tissue recruitment of eosinophils is found to be dependent on interleukin-5 (IL-5) and several CC type chemokines, especially eotaxin...
    James Lillard; Fiscal Year: 2002
    ..b>Chemokines are a family of proteins that are resistant to inactivation by pH or proteolysis as well as affect the ..
    Michael Coffey; Fiscal Year: 2000
    ..The objective of this proposal is to examine the role C-C chemokines play in the regulation of HIV replication in AM...
  72. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..Leukocyte adhesion to endothelium is mediated through both chemokines and adhesion molecules on ECs, and the expression of these molecules is critically up- regulated by nuclear ..
    JACQUELYN MAHER; Fiscal Year: 2000
    ..The main focus of the research will be on C-X-C chemokines. C-X-C chemokines are potent neutrophil chemoattractants and activators; when produced in the liver in vivo, ..
  74. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    ..The chemokines Interleukin-8 (IL8) and Growth-Regulated Oncogene alpha (GROalpha) control much of the normal function of ..
    Linda Bradley; Fiscal Year: 2001
    ..b>Chemokines regulate adhesion of cells to vascular endothelium and, via chemoattractant effects, govern cellular recruitment ..
  76. Hydrogen Deuterium Exchange Mapping of Chemokine Receptor Complex Interfaces
    Tracy Handel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chemokines are critical mediators of cell migration during immune surveillance, lymphocyte development, and inflammation...
    M Zink; Fiscal Year: 2003
    ..interactions that result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...