inflammation mediators

Summary

Summary: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

Top Publications

  1. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  2. ncbi Origin and physiological roles of inflammation
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 454:428-35. 2008
  3. pmc Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:349-61. 2008
  4. ncbi Nonresolving inflammation
    Carl Nathan
    Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA
    Cell 140:871-82. 2010
  5. ncbi The inflammasome: an integrated view
    Olaf Gross
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 243:136-51. 2011
  6. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
  7. ncbi Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction
    René R S Packard
    Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Clin Chem 54:24-38. 2008
  8. ncbi Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:101-37. 2007
  9. pmc Monocytes in atherosclerosis: subsets and functions
    Kevin J Woollard
    Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
    Nat Rev Cardiol 7:77-86. 2010
  10. pmc Immune and inflammatory mechanisms of atherosclerosis (*)
    Elena Galkina
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507 1696, USA
    Annu Rev Immunol 27:165-97. 2009

Research Grants

  1. LUNG IMMUNOPATHOLOGY TRAINING
    Nicholas W Lukacs; Fiscal Year: 2013
  2. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2009
  3. CELL INTERACTIONS IN ENDOMETRIOSIS
    JOHN HASKILL; Fiscal Year: 1992
  4. Atherothrombosis
    Peter Libby; Fiscal Year: 2005
  5. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
  6. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
  7. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
  8. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
  9. Epigenetic Regulation of MMP-13
    MARY GOLDRING; Fiscal Year: 2008
  10. Leukocyte C2GIcNAcT-I in atherosclerosis
    Yuqing Huo; Fiscal Year: 2009

Detail Information

Publications323 found, 100 shown here

  1. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  2. ncbi Origin and physiological roles of inflammation
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 454:428-35. 2008
    ..Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases...
  3. pmc Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:349-61. 2008
    ..These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence...
  4. ncbi Nonresolving inflammation
    Carl Nathan
    Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA
    Cell 140:871-82. 2010
    ..This greatly complicates the development of anti-inflammatory therapies. The problem calls for conceptual, organizational, and statistical innovations...
  5. ncbi The inflammasome: an integrated view
    Olaf Gross
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 243:136-51. 2011
    ....
  6. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
    ..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
  7. ncbi Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction
    René R S Packard
    Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Clin Chem 54:24-38. 2008
    ..This review retraces the biology of atherothrombosis and the evidence supporting the role of inflammatory biomarkers in predicting primary cardiovascular events in this biologic context...
  8. ncbi Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:101-37. 2007
    ..Given the potent actions of lipoxins, resolvins, and protectins in models of human disease, deficiencies in resolution pathways may contribute to many diseases and offer exciting new potential for therapeutic control via resolution...
  9. pmc Monocytes in atherosclerosis: subsets and functions
    Kevin J Woollard
    Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
    Nat Rev Cardiol 7:77-86. 2010
    ....
  10. pmc Immune and inflammatory mechanisms of atherosclerosis (*)
    Elena Galkina
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507 1696, USA
    Annu Rev Immunol 27:165-97. 2009
    ..Regulatory T cells and B1 cells secreting natural antibodies are atheroprotective. This review summarizes our current understanding of inflammatory and immune mechanisms in atherosclerosis...
  11. ncbi Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
    ..Understanding the inflammatory response prevalent in ischemic kidney injury will facilitate identification of molecular targets for therapeutic intervention...
  12. pmc Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways
    Ji Nan Dai
    Department of Anatomy, Kunming Medical University, Kunming, Yunnan, China
    PLoS ONE 6:e21891. 2011
    ..The current study investigates the potential mechanisms whereby gastrodin affects the expression of potentially pro-inflammatory proteins by cultured murine microglial BV-2 cells stimulated with lipopolysaccharide (LPS)...
  13. ncbi Inflammation 2010: new adventures of an old flame
    Ruslan Medzhitov
    Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 140:771-6. 2010
    ..Inflammation comes at the cost of a transient decline in tissue function, which can in turn contribute to the pathogenesis of diseases of altered homeostasis...
  14. ncbi Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis
    Ayan Ghoshal
    National Brain Research Centre, Manesar, Haryana, India
    Glia 55:483-96. 2007
    ..It is likely that the increased microglial activation triggers bystander damage, as the animals eventually succumb to infection...
  15. ncbi The vagus nerve and the nicotinic anti-inflammatory pathway
    Luis Ulloa
    Center of Immunology and Inflammation, Institute for Medical Research, North Shore University Hospital, 350 Community Drive, New York 11030, USA
    Nat Rev Drug Discov 4:673-84. 2005
    ..Similar to the development of alpha- and beta-agonists for adrenoceptors, selective agonists for alpha7nAChR could represent a promising pharmacological strategy against infectious and inflammatory diseases...
  16. ncbi Oxidative stress and left ventricular remodelling after myocardial infarction
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cardiovasc Res 81:457-64. 2009
    ..Since the extent of LV remodelling is a major predictor of prognosis of the patients with MI, the therapeutic approach to attenuating LV remodelling is critically important...
  17. ncbi Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    Carle Ryckman
    Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
    J Immunol 170:3233-42. 2003
    ..These studies 1) show that S100A8, S100A9, and S100A8/A9 are potent stimulators of neutrophils and 2) strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites...
  18. ncbi Mediators of chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, United Kingdom
    Pharmacol Rev 56:515-48. 2004
    ..The identification of inflammatory mediators and understanding their interactions is important for the development of anti-inflammatory treatments for this important disease...
  19. ncbi IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    Katia Boniface
    Laboratoire Cytokines et Inflammation, UPRES EA 3806, Pole Biologie Sante, Universite de Poitiers, Poitiers, France
    J Immunol 174:3695-702. 2005
    ..Finally, we show that IL-22 strongly induces hyperplasia of reconstituted human epidermis. Taken together, these results suggest that IL-22 plays an important role in skin inflammatory processes and wound healing...
  20. ncbi The resolution of inflammation
    Christopher D Buckley
    Rheumatology Research Group at the Centre for Translational Inflammation Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, B15 2WD, UK
    Nat Rev Immunol 13:59-66. 2013
    ....
  21. ncbi Inflammatory cytokines and postmyocardial infarction remodeling
    Min Nian
    Heart and Stroke RL Centre of Excellence, NCSB11 1266, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
    Circ Res 94:1543-53. 2004
    ..Thus, the insightful modulation of cytokines through current and future therapies could promote improved healing and cardiac remodeling postmyocardial infarction...
  22. ncbi Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    Javier R Caso
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
    Circulation 115:1599-608. 2007
    ..We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway...
  23. pmc ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension
    Srinivas Sriramula
    Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Cardiovasc Res 92:401-8. 2011
    ..In the present study, we hypothesized that ACE2 overexpression in the PVN will have beneficial effects in counteracting Ang II-induced hypertension...
  24. ncbi Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Singapore
    J Pathol 202:145-56. 2004
    ..It is reasonable to speculate that elucidation of the key mediators in ARDS coupled with the discovery of specific inhibitors would make it possible to develop clinically effective anti-inflammatory therapy...
  25. ncbi Neuroendocrine regulation of immunity
    Jeanette I Webster
    Section on Neuroimmune Immunology and Behavior, National Institute of Mental Health, Bldg 36, Room 1A 23 MSC 4020, 36 Convent Drive, Bethesda, Maryland 20892 4020, USA
    Annu Rev Immunol 20:125-63. 2002
    ..Particular details are presented on the effects of interruptions of this regulatory loop at multiple levels in predisposition and expression of immune diseases and on mechanisms of glucocorticoid effects on immune cells and molecules...
  26. pmc Molecular inflammation: underpinnings of aging and age-related diseases
    Hae Young Chung
    Department of Pharmacy, Longevity Science and Technology Institutes, Research Institute for Drug Development, Pusan National University, Geumjeong Gu, Busan 609 735, South Korea
    Ageing Res Rev 8:18-30. 2009
    ....
  27. ncbi Modulation of immune response by head injury
    Maria Cristina Morganti-Kossmann
    Department of Trauma Surgery, The Alfred Hospital, Monash University, Commercial Road, Melbourne, VIC 3004, Australia
    Injury 38:1392-400. 2007
    ..This review article discusses the notion that the inflammatory response to TBI is no longer a peripherally mediated phenomenon, and that the CNS significantly influences the immunological sequence of events in the aftermath of injury...
  28. pmc Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?
    Charles N Serhan
    Director, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 8, Boston, MA 02115, USA
    Am J Pathol 177:1576-91. 2010
    ....
  29. ncbi Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers
    F D'Aiuto
    Department of Periodontology, Eastman Dental Institute and Hospital, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Dent Res 83:156-60. 2004
    ..Periodontitis may add to the systemic inflammatory burden of affected individuals...
  30. pmc Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
    Mol Med 14:64-78. 2008
    ..This constitutes a prerequisite to a staging system for individualized treatment for these hitherto deadly syndromes...
  31. pmc The biological functions of T helper 17 cell effector cytokines in inflammation
    Wenjun Ouyang
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Immunity 28:454-67. 2008
    ..The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity...
  32. pmc Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:15-23. 2009
    ..These findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MPhis in tissue homeostasis, inflammation resolution, wound healing, and host defense...
  33. pmc The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis
    Jonas Hannestad
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 36:2452-9. 2011
    ....
  34. ncbi Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
    A N Vgontzas
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:2119-26. 2004
    ..Given the potential association of these behavioral and physical alterations with health, well-being, and public safety, the idea that sleep or parts of it are optional should be regarded with caution...
  35. pmc Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity
    Atsushi Kato
    Division of Allergy Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Immunol 19:711-20. 2007
    ..Improved understanding of epithelial immune and inflammatory responses will hopefully suggest new strategies for therapeutic intervention...
  36. ncbi Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity
    Ilia J Elenkov
    Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 966:290-303. 2002
    ....
  37. ncbi Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease
    S D Aaron
    Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Am J Respir Crit Care Med 163:349-55. 2001
    ....
  38. pmc Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1723-34. 2011
    ..Our studies have thus demonstrated that miR-146a plays a crucial role for in vitro monocytic cell-based endotoxin-induced cross-tolerance...
  39. ncbi Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
    Naveen Gupta
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:1855-63. 2007
    ..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice...
  40. pmc Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia
    Ryan A Frieler
    Department of Internal Medicine, Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Mich 48109, USA
    Stroke 42:179-85. 2011
    ..In the present study, we examined the contribution of myeloid cell MR during focal cerebral ischemia using myeloid-specific MR knockout mice...
  41. pmc HMGB1: endogenous danger signaling
    John R Klune
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mol Med 14:476-84. 2008
    ..The complex functions of HMGB1 as an archetypical alarmin are outlined here to review our current understanding of a molecule that holds the potential for treatment in many important human conditions...
  42. ncbi Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    Patrizia Ziccardi
    Department of Geriatrics and Metabolic Diseases, Chair of Metabolic Diseases, Second University of Naples, Italy
    Circulation 105:804-9. 2002
    ..Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response...
  43. ncbi Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Stephan Baldus
    University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:1440-5. 2003
    ..However, whether MPO also provides prognostic information in patients with ACS remains unknown...
  44. pmc Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:1170-84. 2010
    ..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies...
  45. pmc Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    Guangwen Ren
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
    J Immunol 184:2321-8. 2010
    ..Taken together, these findings reveal a novel function of adhesion molecules in immunoregulation by MSCs and provide new insights for the clinical studies of antiadhesion therapies in various immune disorders...
  46. ncbi Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation
    Renata C O Zanardo
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    FASEB J 20:2118-20. 2006
    ..These results suggest that endogenous H2S is an important mediator of acute inflammation, acting at the leukocyte-endothelium interface. These findings have important implications for anti-inflammatory drug development...
  47. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
    ....
  48. ncbi The cytokine network in chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 41:631-8. 2009
    ....
  49. pmc Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:1209-16. 2006
    ..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
  50. ncbi Innate immunity and inflammation: a transcriptional paradigm
    J Hawiger
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Immunol Res 23:99-109. 2001
    ..Thus, systemic inflammatory responses are critically dependent on the transcriptional activation ofcytokine genes that are controlled by NF-kappaB and other SRTFs...
  51. ncbi Critical role of TLR4 response in the activation of microglia induced by ethanol
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia 46012, Spain
    J Immunol 183:4733-44. 2009
    ....
  52. ncbi Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK
    Kenrie P Y Hui
    Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Immunol 182:1088-98. 2009
    ....
  53. pmc Specialized pro-resolving lipid mediators in the inflammatory response: An update
    Gerard Bannenberg
    Department of Plant Molecular Genetics, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
    Biochim Biophys Acta 1801:1260-73. 2010
    ....
  54. pmc Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile
    Julian Maggini
    Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    PLoS ONE 5:e9252. 2010
    ....
  55. pmc Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution
    Kie Kasuga
    Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 181:8677-87. 2008
    ..Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution...
  56. ncbi The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
    Chris J Malkin
    Cardiology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom S10 2JF
    J Clin Endocrinol Metab 89:3313-8. 2004
    ....
  57. ncbi Adding fuel to fire: microRNAs as a new class of mediators of inflammation
    F J Sheedy
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Ann Rheum Dis 67:iii50-5. 2008
    ..The potential of miRNAs for improving our understanding of the pathogenesis of diseases such as rheumatoid arthritis, and for developing potentially new treatments for these diseases, is substantial...
  58. ncbi Changes in bronchial inflammation during acute exacerbations of chronic bronchitis
    S Gompertz
    Dept of Respiratory Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Eur Respir J 17:1112-9. 2001
    ..Purulent exacerbations are related to bacterial infection, and are associated with increased neutrophilic inflammation and increased leukotriene B4 concentrations...
  59. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
    ..The aim of this study was to examine the association between haplotypes of CRP, IL6 and FGB genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition)...
  60. ncbi A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    Michael B Reed
    Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Nature 431:84-7. 2004
    ..Furthermore, the overproduction of PGL by M. tuberculosis or the addition of purified PGL to monocyte-derived macrophages was found to inhibit the release of these pro-inflammatory mediators in a dose-dependent manner...
  61. pmc Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary Critical Care and Sleep Medicine, and Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, NY, USA
    Am J Respir Crit Care Med 173:991-8. 2006
    ..This "colonization" of the tracheobronchial tree, currently believed to be innocuous, could serve as an inflammatory stimulus, independent of current tobacco smoke exposure...
  62. pmc Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    Am J Pathol 173:1415-27. 2008
    ..burgdorferi. These results provide proof of concept for our hypothesis that B. burgdorferi produces inflammatory mediators in the central nervous system, accompanied by glial and neuronal apoptosis...
  63. pmc Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7
    H Yoshikawa
    Department of Immunology and Medicine, Institute of Advanced Medical Science, St Marianna Graduate School of Medicine, Kawasaki, Japan
    Clin Exp Immunol 146:116-23. 2006
    ..Nicotine suppressed the phosphorylation of I-kappaB, and then inhibited the transcriptional activity of nuclear factor-kappaB. These immunosuppressive effects of nicotine may contribute to the regulation of some immune diseases...
  64. ncbi Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury
    Myung Gyu Kim
    Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
    Nephrol Dial Transplant 25:2908-21. 2010
    ..The purpose of this study was to examine the role of kidney CD11c(+) F4/80(+) dendritic subset in the recovery phase of ischaemia/reperfusion injury (IRI)...
  65. ncbi Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale
    Philip C Calder
    Institute of Human Nutrition, University of Southampton, Southampton General Hospital, UK
    Biochimie 91:791-5. 2009
    ..Indeed effects on transcription factors that regulate inflammatory gene expression (e.g. nuclear factor kappaB) seem to be important...
  66. ncbi Nitric oxide and superoxide in inflammation and immune regulation
    T J Guzik
    Chair of Pharmacology, Jagiellonian University School of Medicine, Poland
    J Physiol Pharmacol 54:469-87. 2003
    ..We also discuss potential roles of nitric oxide as a mediator of allergic inflammation...
  67. ncbi Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    J P Eiserich
    Department of Internal Medicine, University of California, Davis 95616, USA
    Nature 391:393-7. 1998
    ..Our data reveal that NO2- may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo...
  68. ncbi Inflammation and atherosclerosis
    Peter Libby
    Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 105:1135-43. 2002
    ....
  69. pmc Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    Veit Hornung
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:847-56. 2008
    ..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal...
  70. ncbi HMGB1 develops enhanced proinflammatory activity by binding to cytokines
    Yonggang Sha
    Department of Medicine, University of Alabama, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    J Immunol 180:2531-7. 2008
    ..These results demonstrate that HMGB1 acquires proinflammatory activity through binding to proinflammatory mediators, such as IL-1beta...
  71. ncbi Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    M E Poynter
    Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 273:32833-41. 1998
    ..Our results suggest that PPARalpha and the genes under its control play a role in the evolution of oxidative stress excesses observed in aging...
  72. ncbi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
    ..Clinical outcomes have been variably affected by fish oil, although some trials report improved gut histology, decreased disease activity, use of corticosteroids and relapse...
  73. pmc Annexin A1 regulates intestinal mucosal injury, inflammation, and repair
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Immunol 181:5035-44. 2008
    ..Together, these results support a role of endogenous AnxA1 in the protective and reparative properties of the intestinal mucosal epithelium...
  74. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  75. ncbi The inflammasome: a danger sensing complex triggering innate immunity
    Virginie Petrilli
    Department of Biochemistry, University of Lausanne, Ch des Boveresses 155, CH 1066, Epalinges, Switzerland
    Curr Opin Immunol 19:615-22. 2007
    ..These and other issues related to the inflammasome are discussed in this review...
  76. ncbi Molecular mechanisms of hypolipidemic effects of curcumin
    Jean Marc Zingg
    Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Biofactors 39:101-21. 2013
    ....
  77. ncbi High mobility group [corrected] box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway
    Hua Sheng Ding
    Institute of Cardiovascular Diseases, China Three Gorges University, Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, 443000 Yichang, Hubei Province, China
    Gene 509:149-53. 2012
    ..This recruitment mechanism is possibly due to its inflammatory and chemokine functions based on the TLR4-dependent pathway...
  78. pmc Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats
    Ruth M Barrientos
    Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:14641-8. 2012
    ..Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes...
  79. pmc Midkine in inflammation
    Ludwig T Weckbach
    Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, 80336 Munich, Germany
    ScientificWorldJournal 11:2491-505. 2011
    ..Here, we review the current understanding of the role of MK in different inflammatory disorders and summarize the knowledge of MK biology...
  80. pmc Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
    L Senolt
    Institute of Rheumatology, 1st Medical Faculty, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic, and University Hospital Giessen, Department of Internal Medicine and Rheumatology, Germany
    Ann Rheum Dis 66:458-63. 2007
    ..Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects...
  81. ncbi Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-β
    Amanda J Edgley
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Victoria, Australia
    Cardiovasc Ther 30:e30-40. 2012
    ..This review focuses on the therapeutic targeting of TGF-β in the prevention of pathological fibrosis in the heart...
  82. ncbi Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease
    J L Mehta
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    J Am Coll Cardiol 31:1217-25. 1998
    ..If patients with an infectious basis of atherosclerosis can be identified, a therapy directed at eradication of the offending organism may be appropriate...
  83. ncbi Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
    Marcin F Osuchowski
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 177:1967-74. 2006
    ..This multifaceted response questions the use of a simple proinflammatory cytokine measurement for classifying the inflammatory status during sepsis...
  84. ncbi Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats
    Seung Won Park
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Pharmacol Exp Ther 320:1002-12. 2007
    ..Pretreatment with a PPARgamma antagonist, 2-chloro-5-nitro-N-phenyl-benzamide (GW9662), prevented the neuroprotection induced by pioglitazone...
  85. pmc Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients
    Zulfitri A Mat Daud
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI, USA
    Vasc Health Risk Manag 8:187-95. 2012
    ..Secondary end points included observation of nutritional and inflammatory status of hypoalbuminemic patients undergoing hemodialysis...
  86. ncbi Effective neuroprotection by ischemic postconditioning is associated with a decreased expression of RGMa and inflammation mediators in ischemic rats
    Yuhan Kong
    Department of Neurology and Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Neurochem Res 38:815-25. 2013
    ..The cerebral protective effect of IPC may be associated with the decreased expression of RGMa and inflammation mediators.
  87. pmc Apolipoprotein E induces antiinflammatory phenotype in macrophages
    Daniel Baitsch
    Center for Laboratory Medicine, University Hospital Munster, and Leibniz Institute for Arteriosclerosis Research, University of Munster, Albert Schweizer Strasse 33, 48129 Munster, Germany
    Arterioscler Thromb Vasc Biol 31:1160-8. 2011
    ..Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages...
  88. pmc Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA
    Cardiovasc Diabetol 11:64. 2012
    ..We compared the acute and chronic effects of the GLP-1 receptor agonist exenatide vs. metformin on endothelial function in patients with obesity and pre-diabetes...
  89. ncbi Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2
    L J H van Tits
    Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 214:345-9. 2011
    ..Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
  90. ncbi Inflammation and coagulation. An overview
    Jari Petaja
    Director, Department of Pediatrics and Gynecology Helsinki University Central Hospital, Finland
    Thromb Res 127:S34-7. 2011
    ..Animal experiments with signaling selective APC-variants show promise in improving the therapeutic efficacy and safety of APC in sepsis...
  91. ncbi Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation
    Eric A Schwartz
    Phoenix VA Health Care System, 650 E Indian School Rd, Phoenix, AZ 85012 1892, USA
    Arterioscler Thromb Vasc Biol 30:802-8. 2010
    ..The present study tests the novel hypothesis that metabolism of SFA cooperatively amplifies Toll-like receptor-4-mediated inflammation...
  92. ncbi Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium
    Ayman Ibrahim
    Appareil Digestif Environnement Nutrition ADEN EA 4311, Medicine, University of Rouen, I F R 23, Institute of Biomedical Research, 22 Boulevard Gambetta, 76183 Rouen Cedex, France
    Clin Nutr 30:678-87. 2011
    ..As long chain n-3 PUFA treatment led to a decreased expression of adhesion molecules in endothelial cells from other organs, we have now investigated their effect on intestinal endothelial cells in vitro and in colitic rats...
  93. pmc Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice
    Matthew R Alexander
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 122:70-9. 2012
    ....
  94. ncbi Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids
    Michael J Zhang
    Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Annu Rev Nutr 32:203-27. 2012
    ..In this review, we describe the endogenous biosynthesis and immunomodulatory actions of resolvins and highlight their emerging roles in health and disease...
  95. pmc Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease
    Koichi Waseda
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Am J Respir Cell Mol Biol 45:851-7. 2011
    ..These data identify the importance of the LTB4-BLT1 pathway in the development of late-phase, allergen-induced airway responsiveness after secondary airway challenge in mice with established airway disease...
  96. ncbi Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being
    Ilia J Elenkov
    Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Via Fosso del Cavaliere 100, 00133 Rome, Italy
    Neurochem Int 52:40-51. 2008
    ..Better understanding of the neuroendocrine control of inflammation may provide critical insights into mechanisms underlying a variety of common human immune-related diseases...
  97. pmc Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation
    Darlene A Dartt
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:4455-66. 2011
    ..Stimulated secretion is terminated by preventing the increase in [Ca(2+)](i) and activation of ERK1/2 by RvD1 and RvE1...
  98. ncbi Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines
    Irundika H K Dias
    School of Life and Health Sciences, Aston University, Birmingham, UK
    J Clin Periodontol 38:1-7. 2011
    ..To determine the effect of periodontitis patients' plasma on the neutrophil oxidative burst and the role of albumin, immunoglobulins (Igs) and cytokines...
  99. ncbi Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration
    Begoña Villar-Cheda
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neurobiol Aging 33:204.e1-11. 2012
    ..Furthermore, the results suggest that manipulation of the brain angiotensin system may constitute an effective neuroprotective strategy against aging-related risk of dopaminergic degeneration...
  100. pmc Macrophage-mediated inflammation in metabolic disease
    Ajay Chawla
    Cardiovascular Research Institute, University of California San Francisco, California 94158 9001, USA
    Nat Rev Immunol 11:738-49. 2011
    ..In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease...
  101. ncbi Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish
    Zai Jun Zhang
    Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, PR China
    Int J Mol Med 27:195-203. 2011
    ..The objective of this study was to provide a scientific rationale for the clinical use of quercetin, leading to its development as an effective therapeutic agent for the treatment of Parkinson's disease...

Research Grants84

  1. LUNG IMMUNOPATHOLOGY TRAINING
    Nicholas W Lukacs; Fiscal Year: 2013
    ..Thus, this T32 has a proven record of training researchers and will continue to successfully train post-doctoral fellows in research related to lung diseases that affect large numbers of patients. ..
  2. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2009
    ..expression of T+E2 induced oncogenes, 4) imbalances in cell proliferation and apoptosis, 5) production of inflammation mediators via COX and/or lypoxygenase (LOX) pathways...
  3. CELL INTERACTIONS IN ENDOMETRIOSIS
    JOHN HASKILL; Fiscal Year: 1992
    ..As a simplified in vitro model for E, we will examine the steady-state mRNA expression and production and inflammation mediators/growth factors and connective tissue components by interacting monocytes and stromal cells...
  4. Atherothrombosis
    Peter Libby; Fiscal Year: 2005
    ..This effort will hasten the translation of research discoveries to promote health of the heart and blood vessels at home and abroad. ..
  5. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
    ..This study has the additional novelty of correlating biomarkers of oxidative stress and inflammation with a cardiovascular endpoint and will establish whether high dose AT decreases atherosclerosis progression. ..
  6. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
  7. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  8. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  9. Epigenetic Regulation of MMP-13
    MARY GOLDRING; Fiscal Year: 2008
    ..The proposed studies will advance considerably our understanding about the importance of DNA methylation in the pathology of OA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  10. Leukocyte C2GIcNAcT-I in atherosclerosis
    Yuqing Huo; Fiscal Year: 2009
    ..These studies will have significant implications for the inhibition of leukocyte C2GlcNAcT-l in the prevention and treatment of atherosclerosis and its complications. ..
  11. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  12. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  13. Inhibition of leukocyte C2GlcNAcT--l reduces thrombosis
    Yuqing Huo; Fiscal Year: 2007
    ..Inhibition of C2GIcNAcT-I may be a novel approach for preventive and therapeutic interventions in arterial thrombosis in atherosclerosis. ..
  14. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2007
    ..abstract_text> ..
  15. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2008
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  16. Stress, Heat-Shock Proteins, and Innate Immunity
    Monika Fleshner; Fiscal Year: 2008
    ..abstract_text> ..
  17. Mechanisms of acute bowel injury Role of NF-KB
    ISABELLE DE PLAEN; Fiscal Year: 2008
    ..This could prevent its progression toward irreversible intestinal damage and improve the survival of premature infants. [unreadable] [unreadable]..
  18. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  19. Role of PKR in Growth Regulation
    Glen Barber; Fiscal Year: 2008
    ..We propose that these aims will lend insight into mechanisms of cell signaling, tumorigenesis and interferon-mediated actions in the cell. ..
  20. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2007
    ..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. [unreadable] [unreadable] [unreadable]..
  21. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  22. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2006
    ....
  23. Biophysiological Mechanisms of 'Heightened Speech'
    Katherine Verdolini; Fiscal Year: 2007
    ..The primary dependent variable is quality of life in relation to voice, measured with the Voice Handicap Index. Secondary variables are aerodynamic, laryngeal, and vocal quality measures. [unreadable] [unreadable]..
  24. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. MOLECULAR IMMUNOLOGY OF MINOR HISTOCOMPATIBILITY ANTIGEN
    Sebastian Joyce; Fiscal Year: 2009
    ..Additionally, the beneficial effects of graft-versus-leukemia, a by-product of GvHD, can be utilised as a therapy against cancers. ..
  26. Modest supplemental oxygen worsens lung injury in a murine model of sepsis
    Neil Aggarwal; Fiscal Year: 2008
    ..This work has the potential to improve human outcomes and decrease burden on the health care system from this devastating illness. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  27. Molecular Basis of iNKT Cell Ontogeny and Function
    Sebastian Joyce; Fiscal Year: 2010
    ..Additionally, this knowledge can lead to the development of therapeutics that either enhance (adjuvant effect, downregulate autoimmunity) or suppress (cerebral malaria, airway hypersensitivity) iNKT cell function. ..
  28. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
  29. Mechanisms of VSV-mediated Oncolysis
    Glen N Barber; Fiscal Year: 2010
    ..Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
  30. MECHANISMS OF EOSINOPHIL DEGRANULATION IN HUMAN DISEASE
    Hirohito Kita; Fiscal Year: 2010
    ..Relevance: Patients with asthma have persistent respiratory problems. This research will investigate how the interaction of immune cells and our environment cause and worsen the disease. ..
  31. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2010
    ..These studies should provide valuable insights into LC regulation of skin immune responses and may lead to improved prevention or treatment of skin GVHD, a major medical problem in transplantation therapy of patients with malignancies. ..
  32. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..
  33. ETHANOL AND MAP KINASE CASCADE
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..New knowledge gained from this project will facilitate development of therapeutic tools to prevent and control ethanol-induced cellular damage. ..
  34. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  35. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  36. Periodontitis, Anti-phospholipids, Dendritic Cells, and Atherosclerosis
    John Tew; Fiscal Year: 2009
    ..A biological mechanism linking periodontitis and atherosclerosis would lend credibility to the epidemiological associations and help provide rationale for long-term longitudinal studies required to demonstrate causality. ..
  37. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..
  38. Uptake of apoptotic cells
    Peter Henson; Fiscal Year: 2009
    ..Approaches includeuse of knockout cells and animals, molecular modification, biochemistry and cell biology and an extensive collaborative network. ..
  39. Molecular Mechanisms Mediating NF-kB2/p100 Processing
    Shao Cong Sun; Fiscal Year: 2007
    ..abstract_text> ..
  40. Inflammatory Mechanisms of Atherosclerosis
    Peter Libby; Fiscal Year: 2006
    ..5. We will explore a putative functional role of a novel prostaglandin E2 receptor EP4 interacting protein (EPRAP) in endogenous anti-inflammatory pathways. ..
  41. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2005
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  42. MICROVASC OBSTRUCTION BY MRI AFTER CORONARY INTERVENTION
    Katherine Wu; Fiscal Year: 2004
    ..abstract_text> ..
  43. Cellular Activation Pathways in Rheumatoid Arthritis
    Joseph Holoshitz; Fiscal Year: 2004
    ..The proposed studies will likely contribute significantly to understanding the pathogenesis of RA and, perhaps, other autoimmune diseases. ..
  44. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  45. TEACHING NUTRITION TO PREVENT CARDIOVASCULAR DISEASES
    Francine Welty; Fiscal Year: 2004
    ..This career award will establish Dr. Walker as a leader in medical education in nutrition, his long-term career goal. ..
  46. Collectin-induced phagocytosis of apoptotic cells
    Peter Henson; Fiscal Year: 2004
    ..Finally, the role of collectins and calreticulin in removal of apoptotic cells and cell debris will be examined in the inflamed peritoneum and lung using inhibitors and knockout mice. ..
  47. Large Scale Images of Gene Transcription in MS and EAE
    Lawrence Steinman; Fiscal Year: 2004
    ..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
  48. EXERCISE, STRESS AND IMMUNITY--PHYSIOLOGICAL MECHANISMS
    Monika Fleshner; Fiscal Year: 2004
    ....
  49. INNATE IMMUNITY AND MYOCARDIAL INJURY
    GREGORY STAHL; Fiscal Year: 2003
    ..abstract_text> ..
  50. Research Conference:Mutagenesis and Carcinogenesis
    LAWRENCE MARNETT; Fiscal Year: 2004
    ..Leading scientists in the field will present and evaluate the latest research at the frontiers of mutagenesis and carcinogenesis. ..
  51. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2002
    ..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
  52. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS
    Paul Ridker; Fiscal Year: 2002
    ....
  53. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  54. IN VIVO TREATMENT OF EAE WITH ANTI I-A ANTIBODIES
    Lawrence Steinman; Fiscal Year: 2001
    ..Aim 5 is to assess the possibility of using DNA vaccination against TCR Vb for treatment of EAE. It is hoped that these studies will provide the basis for future clinical trials in MS patients. ..
  55. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 2003
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  56. FGF-Silyl-Heparin Cerebral Aneurysm Coils
    PAUL ZAMORA; Fiscal Year: 2002
    ..The Phase I studies will develop the coated coils and perform initial animal evaluations. ..
  57. THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMEN
    Paul Ridker; Fiscal Year: 2002
    ....
  58. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  59. Kim-1 in Renal Epithelial Cell Motility and Adhesion
    BENJAMIN HUMPHREYS; Fiscal Year: 2005
    ..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
  60. Latent Mobility Abnormalities and Disability
    Joe Verghese; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  61. Polarized DC as Melanoma Vaccine: Phase 1 Evaluation
    Pawel Kalinski; Fiscal Year: 2006
    ....
  62. PERSISTENT FETAL CELLS IN THE IMMUNOPATHOGENESIS OF SSC
    Carol Artlett; Fiscal Year: 2002
    ..Obviously, the aims of this proposal cannot address the pathogenesis of SSc occurring in males, or in woman who have not had recognized pregnancies or male offspring. ..
  63. Regulatory CD4/CD8 T cells in autoimmune demyelination
    Vipin Kumar; Fiscal Year: 2006
    ..perforin-/- mice. Knowledge of the immune principles involved here is important not only for understanding the biology of immune regulation but also in the design of TCR-based therapeutic approaches for autoimmune conditions in humans. ..
  64. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2006
    ..abstract_text> ..
  65. A Class II MHC-Associated Lymphocyte Activation Defect
    Joseph Holoshitz; Fiscal Year: 2006
    ..These studies will examine a novel paradigm relevant to a physiologic regulatory mechanism in the immune system, whose perturbation may set the stage for immunopathology. ..
  66. REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTES
    MARY GOLDRING; Fiscal Year: 2001
    ....
  67. Histone acetylation by ethanol:Mechanisms & consequence
    SHIVENDRA SHUKLA; Fiscal Year: 2005
    ..abstract_text> ..
  68. PAI-1 and The Vascular Toxicity of Aldosterone
    Nancy Brown; Fiscal Year: 2005
    ..This multi-disciplinary approach will generate new information regarding the role of aldosterone in vascular toxicity and, thus, improve our ability to prevent and treat cardiovascular disease. ..
  69. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ....
  70. RNA directed silencing of HIV and SIV receptors
    Michael Murray; Fiscal Year: 2004
    ..abstract_text> ..
  71. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  72. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2008
    ..abstract_text> ..
  73. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  74. MACROPHAGES, DENDRITIC CELLS AND PATHOGENS
    Carl Nathan; Fiscal Year: 2007
    ..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..
  75. MYOCARDIAL INTEGRINS AND VENTRICULAR REMODELING
    JOSEPH JANICKI; Fiscal Year: 2002
    ....
  76. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
  77. REGULATION OF THE INNATE, IMMUNE RESPONSE BY IL-10
    Thomas Shanley; Fiscal Year: 2002
    ..The information may identify a means to modulate pulmonary inflammation in patients and identify novel biologic effects of IL-10 on viral-mediated inflammatory responses. ..
  78. BEHAVIORAL AND IMMUNOLOGICAL FACTORS IN CORONARY DISEASE
    Willem Kop; Fiscal Year: 2005
    ....
  79. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  80. The Genetic Epidemiology of RA and SLE
    Lindsey Criswell; Fiscal Year: 2005
    ..Criswell's ability to accomplish her goals as a patient-oriented clinical researcher and mentor through the provision of essential resources and relief of patient care and other activities. ..
  81. THE INFLAMMATORY RESPONSE OF THE PANCREATIC ACINAR CELL
    Stephen Pandol; Fiscal Year: 2006
    ..The results of the experiments described in the present application will allow us to propose how CCK, together with a cytokine modulating its effects, acts on the pancreatic acinar cell to cause experimental pancreatitis. ..
  82. AGE RELATED NEURODEGENERATIVE DISEASES IN MICRONESIA
    Douglas Galasko; Fiscal Year: 2006
    ..Subproject by Lee: 'PHF-tau in neurodegenerative diseases of Guam' will assess oxidative markers related to brain lesions in ALS, PDC and dementia. ..
  83. EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAIN
    ANNE FAGAN NIVEN; Fiscal Year: 2005
    ..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
  84. Molecular and Cellular Analyses of Aquaporins in Lung
    LANDON KING; Fiscal Year: 2005
    ..These studies should provide insight into mechanisms regulating expression of AQP1 and AQP5, and establish a framework from which to better understand their role in the pathophysiology of the respiratory tract. ..