Genomes and Genes
Summary: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Publications323 found, 100 shown here
- The nature of small-airway obstruction in chronic obstructive pulmonary diseaseJames C Hogg
University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
N Engl J Med 350:2645-53. 2004..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
- Origin and physiological roles of inflammationRuslan Medzhitov
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
Nature 454:428-35. 2008..Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases...
- Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 8:349-61. 2008..These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence...
- Nonresolving inflammationCarl Nathan
Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA
Cell 140:871-82. 2010..This greatly complicates the development of anti-inflammatory therapies. The problem calls for conceptual, organizational, and statistical innovations...
- The inflammasome: an integrated viewOlaf Gross
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunol Rev 243:136-51. 2011....
- Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
- Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk predictionRené R S Packard
Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Clin Chem 54:24-38. 2008..This review retraces the biology of atherothrombosis and the evidence supporting the role of inflammatory biomarkers in predicting primary cardiovascular events in this biologic context...
- Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathwaysCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Immunol 25:101-37. 2007..Given the potent actions of lipoxins, resolvins, and protectins in models of human disease, deficiencies in resolution pathways may contribute to many diseases and offer exciting new potential for therapeutic control via resolution...
- Monocytes in atherosclerosis: subsets and functionsKevin J Woollard
Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
Nat Rev Cardiol 7:77-86. 2010....
- Immune and inflammatory mechanisms of atherosclerosis (*)Elena Galkina
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507 1696, USA
Annu Rev Immunol 27:165-97. 2009..Regulatory T cells and B1 cells secreting natural antibodies are atheroprotective. This review summarizes our current understanding of inflammatory and immune mechanisms in atherosclerosis...
- Ischemic acute renal failure: an inflammatory disease?Joseph V Bonventre
Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
Kidney Int 66:480-5. 2004..Understanding the inflammatory response prevalent in ischemic kidney injury will facilitate identification of molecular targets for therapeutic intervention...
- Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathwaysJi Nan Dai
Department of Anatomy, Kunming Medical University, Kunming, Yunnan, China
PLoS ONE 6:e21891. 2011..The current study investigates the potential mechanisms whereby gastrodin affects the expression of potentially pro-inflammatory proteins by cultured murine microglial BV-2 cells stimulated with lipopolysaccharide (LPS)...
- Inflammation 2010: new adventures of an old flameRuslan Medzhitov
Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Cell 140:771-6. 2010..Inflammation comes at the cost of a transient decline in tissue function, which can in turn contribute to the pathogenesis of diseases of altered homeostasis...
- Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitisAyan Ghoshal
National Brain Research Centre, Manesar, Haryana, India
Glia 55:483-96. 2007..It is likely that the increased microglial activation triggers bystander damage, as the animals eventually succumb to infection...
- The vagus nerve and the nicotinic anti-inflammatory pathwayLuis Ulloa
Center of Immunology and Inflammation, Institute for Medical Research, North Shore University Hospital, 350 Community Drive, New York 11030, USA
Nat Rev Drug Discov 4:673-84. 2005..Similar to the development of alpha- and beta-agonists for adrenoceptors, selective agonists for alpha7nAChR could represent a promising pharmacological strategy against infectious and inflammatory diseases...
- Oxidative stress and left ventricular remodelling after myocardial infarctionMasatsugu Hori
Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
Cardiovasc Res 81:457-64. 2009..Since the extent of LV remodelling is a major predictor of prognosis of the patients with MI, the therapeutic approach to attenuating LV remodelling is critically important...
- Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesionCarle Ryckman
Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
J Immunol 170:3233-42. 2003..These studies 1) show that S100A8, S100A9, and S100A8/A9 are potent stimulators of neutrophils and 2) strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites...
- Mediators of chronic obstructive pulmonary diseasePeter J Barnes
National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, United Kingdom
Pharmacol Rev 56:515-48. 2004..The identification of inflammatory mediators and understanding their interactions is important for the development of anti-inflammatory treatments for this important disease...
- IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytesKatia Boniface
Laboratoire Cytokines et Inflammation, UPRES EA 3806, Pole Biologie Sante, Universite de Poitiers, Poitiers, France
J Immunol 174:3695-702. 2005..Finally, we show that IL-22 strongly induces hyperplasia of reconstituted human epidermis. Taken together, these results suggest that IL-22 plays an important role in skin inflammatory processes and wound healing...
- The resolution of inflammationChristopher D Buckley
Rheumatology Research Group at the Centre for Translational Inflammation Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, B15 2WD, UK
Nat Rev Immunol 13:59-66. 2013....
- Inflammatory cytokines and postmyocardial infarction remodelingMin Nian
Heart and Stroke RL Centre of Excellence, NCSB11 1266, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
Circ Res 94:1543-53. 2004..Thus, the insightful modulation of cytokines through current and future therapies could promote improved healing and cardiac remodeling postmyocardial infarction...
- Toll-like receptor 4 is involved in brain damage and inflammation after experimental strokeJavier R Caso
Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
Circulation 115:1599-608. 2007..We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway...
- ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertensionSrinivas Sriramula
Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803, USA
Cardiovasc Res 92:401-8. 2011..In the present study, we hypothesized that ACE2 overexpression in the PVN will have beneficial effects in counteracting Ang II-induced hypertension...
- Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndromeMadhav Bhatia
Department of Pharmacology, National University of Singapore, Singapore
J Pathol 202:145-56. 2004..It is reasonable to speculate that elucidation of the key mediators in ARDS coupled with the discovery of specific inhibitors would make it possible to develop clinically effective anti-inflammatory therapy...
- Neuroendocrine regulation of immunityJeanette I Webster
Section on Neuroimmune Immunology and Behavior, National Institute of Mental Health, Bldg 36, Room 1A 23 MSC 4020, 36 Convent Drive, Bethesda, Maryland 20892 4020, USA
Annu Rev Immunol 20:125-63. 2002..Particular details are presented on the effects of interruptions of this regulatory loop at multiple levels in predisposition and expression of immune diseases and on mechanisms of glucocorticoid effects on immune cells and molecules...
- Molecular inflammation: underpinnings of aging and age-related diseasesHae Young Chung
Department of Pharmacy, Longevity Science and Technology Institutes, Research Institute for Drug Development, Pusan National University, Geumjeong Gu, Busan 609 735, South Korea
Ageing Res Rev 8:18-30. 2009....
- Modulation of immune response by head injuryMaria Cristina Morganti-Kossmann
Department of Trauma Surgery, The Alfred Hospital, Monash University, Commercial Road, Melbourne, VIC 3004, Australia
Injury 38:1392-400. 2007..This review article discusses the notion that the inflammatory response to TBI is no longer a peripherally mediated phenomenon, and that the CNS significantly influences the immunological sequence of events in the aftermath of injury...
- Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?Charles N Serhan
Director, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 8, Boston, MA 02115, USA
Am J Pathol 177:1576-91. 2010....
- Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markersF D'Aiuto
Department of Periodontology, Eastman Dental Institute and Hospital, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
J Dent Res 83:156-60. 2004..Periodontitis may add to the systemic inflammatory burden of affected individuals...
- Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremonyGuillaume Monneret
Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
Mol Med 14:64-78. 2008..This constitutes a prerequisite to a staging system for individualized treatment for these hitherto deadly syndromes...
- The biological functions of T helper 17 cell effector cytokines in inflammationWenjun Ouyang
Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
Immunity 28:454-67. 2008..The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity...
- Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actionsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 206:15-23. 2009..These findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MPhis in tissue homeostasis, inflammation resolution, wound healing, and host defense...
- The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysisJonas Hannestad
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Neuropsychopharmacology 36:2452-9. 2011....
- Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokinesA N Vgontzas
Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Clin Endocrinol Metab 89:2119-26. 2004..Given the potential association of these behavioral and physical alterations with health, well-being, and public safety, the idea that sleep or parts of it are optional should be regarded with caution...
- Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunityAtsushi Kato
Division of Allergy Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Curr Opin Immunol 19:711-20. 2007..Improved understanding of epithelial immune and inflammatory responses will hopefully suggest new strategies for therapeutic intervention...
- Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunityIlia J Elenkov
Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
Ann N Y Acad Sci 966:290-303. 2002....
- Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary diseaseS D Aaron
Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Am J Respir Crit Care Med 163:349-55. 2001....
- Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signalingMd A Nahid
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
J Immunol 186:1723-34. 2011..Our studies have thus demonstrated that miR-146a plays a crucial role for in vitro monocytic cell-based endotoxin-induced cross-tolerance...
- Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in miceNaveen Gupta
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 179:1855-63. 2007..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice...
- Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemiaRyan A Frieler
Department of Internal Medicine, Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Mich 48109, USA
Stroke 42:179-85. 2011..In the present study, we examined the contribution of myeloid cell MR during focal cerebral ischemia using myeloid-specific MR knockout mice...
- HMGB1: endogenous danger signalingJohn R Klune
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mol Med 14:476-84. 2008..The complex functions of HMGB1 as an archetypical alarmin are outlined here to review our current understanding of a molecule that holds the potential for treatment in many important human conditions...
- Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one yearPatrizia Ziccardi
Department of Geriatrics and Metabolic Diseases, Chair of Metabolic Diseases, Second University of Naples, Italy
Circulation 105:804-9. 2002..Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response...
- Myeloperoxidase serum levels predict risk in patients with acute coronary syndromesStephan Baldus
University of Hamburg, Department of Cardiology, Martinistrasse 52, 20246 Hamburg, Germany
Circulation 108:1440-5. 2003..However, whether MPO also provides prognostic information in patients with ACS remains unknown...
- Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statinsMatthew Spite
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circ Res 107:1170-84. 2010..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies...
- Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppressionGuangwen Ren
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
J Immunol 184:2321-8. 2010..Taken together, these findings reveal a novel function of adhesion molecules in immunoregulation by MSCs and provide new insights for the clinical studies of antiadhesion therapies in various immune disorders...
- Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammationRenata C O Zanardo
Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
FASEB J 20:2118-20. 2006..These results suggest that endogenous H2S is an important mediator of acute inflammation, acting at the leukocyte-endothelium interface. These findings have important implications for anti-inflammatory drug development...
- Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surfaceLihui Luo
Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
Invest Ophthalmol Vis Sci 45:4293-301. 2004....
- The cytokine network in chronic obstructive pulmonary diseasePeter J Barnes
National Heart and Lung Institute, Imperial College London, London, United Kingdom
Am J Respir Cell Mol Biol 41:631-8. 2009....
- Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expressionAmiram Ariel
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 7:1209-16. 2006..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
- Innate immunity and inflammation: a transcriptional paradigmJ Hawiger
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
Immunol Res 23:99-109. 2001..Thus, systemic inflammatory responses are critically dependent on the transcriptional activation ofcytokine genes that are controlled by NF-kappaB and other SRTFs...
- Critical role of TLR4 response in the activation of microglia induced by ethanolSara Fernandez-Lizarbe
Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia 46012, Spain
J Immunol 183:4733-44. 2009....
- Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPKKenrie P Y Hui
Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
J Immunol 182:1088-98. 2009....
- Specialized pro-resolving lipid mediators in the inflammatory response: An updateGerard Bannenberg
Department of Plant Molecular Genetics, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
Biochim Biophys Acta 1801:1260-73. 2010....
- Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profileJulian Maggini
Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
PLoS ONE 5:e9252. 2010....
- Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolutionKie Kasuga
Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 181:8677-87. 2008..Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution...
- The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal menChris J Malkin
Cardiology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom S10 2JF
J Clin Endocrinol Metab 89:3313-8. 2004....
- Adding fuel to fire: microRNAs as a new class of mediators of inflammationF J Sheedy
School of Biochemistry and Immunology, Trinity College Dublin, Ireland
Ann Rheum Dis 67:iii50-5. 2008..The potential of miRNAs for improving our understanding of the pathogenesis of diseases such as rheumatoid arthritis, and for developing potentially new treatments for these diseases, is substantial...
- Changes in bronchial inflammation during acute exacerbations of chronic bronchitisS Gompertz
Dept of Respiratory Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
Eur Respir J 17:1112-9. 2001..Purulent exacerbations are related to bacterial infection, and are associated with increased neutrophilic inflammation and increased leukotriene B4 concentrations...
- IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control studyDilyara G Yanbaeva
Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
BMC Med Genet 10:23. 2009..The aim of this study was to examine the association between haplotypes of CRP, IL6 and FGB genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition)...
- A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune responseMichael B Reed
Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
Nature 431:84-7. 2004..Furthermore, the overproduction of PGL by M. tuberculosis or the addition of purified PGL to monocyte-derived macrophages was found to inhibit the release of these pro-inflammatory mediators in a dose-dependent manner...
- Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary diseaseSanjay Sethi
Division of Pulmonary Critical Care and Sleep Medicine, and Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, NY, USA
Am J Respir Crit Care Med 173:991-8. 2006..This "colonization" of the tracheobronchial tree, currently believed to be innocuous, could serve as an inflammatory stimulus, independent of current tobacco smoke exposure...
- Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosisGeeta Ramesh
Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
Am J Pathol 173:1415-27. 2008..burgdorferi. These results provide proof of concept for our hypothesis that B. burgdorferi produces inflammatory mediators in the central nervous system, accompanied by glial and neuronal apoptosis...
- Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7H Yoshikawa
Department of Immunology and Medicine, Institute of Advanced Medical Science, St Marianna Graduate School of Medicine, Kawasaki, Japan
Clin Exp Immunol 146:116-23. 2006..Nicotine suppressed the phosphorylation of I-kappaB, and then inhibited the transcriptional activity of nuclear factor-kappaB. These immunosuppressive effects of nicotine may contribute to the regulation of some immune diseases...
- Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injuryMyung Gyu Kim
Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
Nephrol Dial Transplant 25:2908-21. 2010..The purpose of this study was to examine the role of kidney CD11c(+) F4/80(+) dendritic subset in the recovery phase of ischaemia/reperfusion injury (IRI)...
- Polyunsaturated fatty acids and inflammatory processes: New twists in an old talePhilip C Calder
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, UK
Biochimie 91:791-5. 2009..Indeed effects on transcription factors that regulate inflammatory gene expression (e.g. nuclear factor kappaB) seem to be important...
- Nitric oxide and superoxide in inflammation and immune regulationT J Guzik
Chair of Pharmacology, Jagiellonian University School of Medicine, Poland
J Physiol Pharmacol 54:469-87. 2003..We also discuss potential roles of nitric oxide as a mediator of allergic inflammation...
- Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophilsJ P Eiserich
Department of Internal Medicine, University of California, Davis 95616, USA
Nature 391:393-7. 1998..Our data reveal that NO2- may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo...
- Inflammation and atherosclerosisPeter Libby
Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 105:1135-43. 2002....
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationVeit Hornung
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:847-56. 2008..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal...
- HMGB1 develops enhanced proinflammatory activity by binding to cytokinesYonggang Sha
Department of Medicine, University of Alabama, 1530 3rd Avenue South, Birmingham, AL 35294, USA
J Immunol 180:2531-7. 2008..These results demonstrate that HMGB1 acquires proinflammatory activity through binding to proinflammatory mediators, such as IL-1beta...
- Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in agingM E Poynter
Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
J Biol Chem 273:32833-41. 1998..Our results suggest that PPARalpha and the genes under its control play a role in the evolution of oxidative stress excesses observed in aging...
- Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseasesPhilip C Calder
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
Mol Nutr Food Res 52:885-97. 2008..Clinical outcomes have been variably affected by fish oil, although some trials report improved gut histology, decreased disease activity, use of corticosteroids and relapse...
- Annexin A1 regulates intestinal mucosal injury, inflammation, and repairBrian A Babbin
Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA 30322, USA
J Immunol 181:5035-44. 2008..Together, these results support a role of endogenous AnxA1 in the protective and reparative properties of the intestinal mucosal epithelium...
- IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pain 135:232-9. 2008..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
- The inflammasome: a danger sensing complex triggering innate immunityVirginie Petrilli
Department of Biochemistry, University of Lausanne, Ch des Boveresses 155, CH 1066, Epalinges, Switzerland
Curr Opin Immunol 19:615-22. 2007..These and other issues related to the inflammasome are discussed in this review...
- Molecular mechanisms of hypolipidemic effects of curcuminJean Marc Zingg
Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Biofactors 39:101-21. 2013....
- High mobility group [corrected] box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathwayHua Sheng Ding
Institute of Cardiovascular Diseases, China Three Gorges University, Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, 443000 Yichang, Hubei Province, China
Gene 509:149-53. 2012..This recruitment mechanism is possibly due to its inflammatory and chemokine functions based on the TLR4-dependent pathway...
- Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged ratsRuth M Barrientos
Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
J Neurosci 32:14641-8. 2012..Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes...
- Midkine in inflammationLudwig T Weckbach
Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat, 80336 Munich, Germany
ScientificWorldJournal 11:2491-505. 2011..Here, we review the current understanding of the role of MK in different inflammatory disorders and summarize the knowledge of MK biology...
- Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serumL Senolt
Institute of Rheumatology, 1st Medical Faculty, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic, and University Hospital Giessen, Department of Internal Medicine and Rheumatology, Germany
Ann Rheum Dis 66:458-63. 2007..Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. In humans, proinflammatory properties of resistin are superior to its insulin resistance-inducing effects...
- Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-βAmanda J Edgley
Department of Medicine, St Vincent s Hospital, University of Melbourne, Victoria, Australia
Cardiovasc Ther 30:e30-40. 2012..This review focuses on the therapeutic targeting of TGF-β in the prevention of pathological fibrosis in the heart...
- Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery diseaseJ L Mehta
Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
J Am Coll Cardiol 31:1217-25. 1998..If patients with an infectious basis of atherosclerosis can be identified, a therapy directed at eradication of the offending organism may be appropriate...
- Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortalityMarcin F Osuchowski
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 177:1967-74. 2006..This multifaceted response questions the use of a simple proinflammatory cytokine measurement for classifying the inflammatory status during sepsis...
- Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult ratsSeung Won Park
Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
J Pharmacol Exp Ther 320:1002-12. 2007..Pretreatment with a PPARgamma antagonist, 2-chloro-5-nitro-N-phenyl-benzamide (GW9662), prevented the neuroprotection induced by pioglitazone...
- Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patientsZulfitri A Mat Daud
Department of Nutrition and Food Science, Wayne State University, Detroit, MI, USA
Vasc Health Risk Manag 8:187-95. 2012..Secondary end points included observation of nutritional and inflammatory status of hypoalbuminemic patients undergoing hemodialysis...
- Effective neuroprotection by ischemic postconditioning is associated with a decreased expression of RGMa and inflammation mediators in ischemic ratsYuhan Kong
Department of Neurology and Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Neurochem Res 38:815-25. 2013..The cerebral protective effect of IPC may be associated with the decreased expression of RGMa and inflammation mediators.
- Apolipoprotein E induces antiinflammatory phenotype in macrophagesDaniel Baitsch
Center for Laboratory Medicine, University Hospital Munster, and Leibniz Institute for Arteriosclerosis Research, University of Munster, Albert Schweizer Strasse 33, 48129 Munster, Germany
Arterioscler Thromb Vasc Biol 31:1160-8. 2011..Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages...
- Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trialAaron S Kelly
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA
Cardiovasc Diabetol 11:64. 2012..We compared the acute and chronic effects of the GLP-1 receptor agonist exenatide vs. metformin on endothelial function in patients with obesity and pre-diabetes...
- Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2L J H van Tits
Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Atherosclerosis 214:345-9. 2011..Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
- Inflammation and coagulation. An overviewJari Petaja
Director, Department of Pediatrics and Gynecology Helsinki University Central Hospital, Finland
Thromb Res 127:S34-7. 2011..Animal experiments with signaling selective APC-variants show promise in improving the therapeutic efficacy and safety of APC in sepsis...
- Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammationEric A Schwartz
Phoenix VA Health Care System, 650 E Indian School Rd, Phoenix, AZ 85012 1892, USA
Arterioscler Thromb Vasc Biol 30:802-8. 2010..The present study tests the novel hypothesis that metabolism of SFA cooperatively amplifies Toll-like receptor-4-mediated inflammation...
- Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endotheliumAyman Ibrahim
Appareil Digestif Environnement Nutrition ADEN EA 4311, Medicine, University of Rouen, I F R 23, Institute of Biomedical Research, 22 Boulevard Gambetta, 76183 Rouen Cedex, France
Clin Nutr 30:678-87. 2011..As long chain n-3 PUFA treatment led to a decreased expression of adhesion molecules in endothelial cells from other organs, we have now investigated their effect on intestinal endothelial cells in vitro and in colitic rats...
- Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in miceMatthew R Alexander
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
J Clin Invest 122:70-9. 2012....
- Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acidsMichael J Zhang
Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Annu Rev Nutr 32:203-27. 2012..In this review, we describe the endogenous biosynthesis and immunomodulatory actions of resolvins and highlight their emerging roles in health and disease...
- Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established diseaseKoichi Waseda
Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Am J Respir Cell Mol Biol 45:851-7. 2011..These data identify the importance of the LTB4-BLT1 pathway in the development of late-phase, allergen-induced airway responsiveness after secondary airway challenge in mice with established airway disease...
- Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-beingIlia J Elenkov
Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Via Fosso del Cavaliere 100, 00133 Rome, Italy
Neurochem Int 52:40-51. 2008..Better understanding of the neuroendocrine control of inflammation may provide critical insights into mechanisms underlying a variety of common human immune-related diseases...
- Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammationDarlene A Dartt
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
J Immunol 186:4455-66. 2011..Stimulated secretion is terminated by preventing the increase in [Ca(2+)](i) and activation of ERK1/2 by RvD1 and RvE1...
- Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokinesIrundika H K Dias
School of Life and Health Sciences, Aston University, Birmingham, UK
J Clin Periodontol 38:1-7. 2011..To determine the effect of periodontitis patients' plasma on the neutrophil oxidative burst and the role of albumin, immunoglobulins (Igs) and cytokines...
- Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degenerationBegoña Villar-Cheda
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Neurobiol Aging 33:204.e1-11. 2012..Furthermore, the results suggest that manipulation of the brain angiotensin system may constitute an effective neuroprotective strategy against aging-related risk of dopaminergic degeneration...
- Macrophage-mediated inflammation in metabolic diseaseAjay Chawla
Cardiovascular Research Institute, University of California San Francisco, California 94158 9001, USA
Nat Rev Immunol 11:738-49. 2011..In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease...
- Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafishZai Jun Zhang
Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, PR China
Int J Mol Med 27:195-203. 2011..The objective of this study was to provide a scientific rationale for the clinical use of quercetin, leading to its development as an effective therapeutic agent for the treatment of Parkinson's disease...
- LUNG IMMUNOPATHOLOGY TRAININGNicholas W Lukacs; Fiscal Year: 2013..Thus, this T32 has a proven record of training researchers and will continue to successfully train post-doctoral fellows in research related to lung diseases that affect large numbers of patients. ..
- Hormone-induced inflammation and prostate cancerShuk Mei Ho; Fiscal Year: 2009..expression of T+E2 induced oncogenes, 4) imbalances in cell proliferation and apoptosis, 5) production of inflammation mediators via COX and/or lypoxygenase (LOX) pathways...
- CELL INTERACTIONS IN ENDOMETRIOSISJOHN HASKILL; Fiscal Year: 1992..As a simplified in vitro model for E, we will examine the steady-state mRNA expression and production and inflammation mediators/growth factors and connective tissue components by interacting monocytes and stromal cells...
- AtherothrombosisPeter Libby; Fiscal Year: 2005..This effort will hasten the translation of research discoveries to promote health of the heart and blood vessels at home and abroad. ..
- High Dose Alpha Tocopherol and Carotid AtherosclerosisIshwarlal Jialal; Fiscal Year: 2004..This study has the additional novelty of correlating biomarkers of oxidative stress and inflammation with a cardiovascular endpoint and will establish whether high dose AT decreases atherosclerosis progression. ..
- CRP, Diabetes, AtherothrombosisIshwarlal Jialal; Fiscal Year: 2010..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
- REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTIONMarilyn Cipolla; Fiscal Year: 2003..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
- Cerebral Arteriole Function during Hyperglycemic StrokeMarilyn Cipolla; Fiscal Year: 2009....
- Epigenetic Regulation of MMP-13MARY GOLDRING; Fiscal Year: 2008..The proposed studies will advance considerably our understanding about the importance of DNA methylation in the pathology of OA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Leukocyte C2GIcNAcT-I in atherosclerosisYuqing Huo; Fiscal Year: 2009..These studies will have significant implications for the inhibition of leukocyte C2GlcNAcT-l in the prevention and treatment of atherosclerosis and its complications. ..
- Inflammation and Infection as Risk Factors in StrokeMitchell Elkind; Fiscal Year: 2006..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
- Levels of Inflammatory Markers in Treatment of StrokeMitchell Elkind; Fiscal Year: 2008..abstract_text> ..
- Inhibition of leukocyte C2GlcNAcT--l reduces thrombosisYuqing Huo; Fiscal Year: 2007..Inhibition of C2GIcNAcT-I may be a novel approach for preventive and therapeutic interventions in arterial thrombosis in atherosclerosis. ..
- MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIAGREGORY STAHL; Fiscal Year: 2007..abstract_text> ..
- IL-15Ra and NK Cell FunctionAveril Ma; Fiscal Year: 2008..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
- Stress, Heat-Shock Proteins, and Innate ImmunityMonika Fleshner; Fiscal Year: 2008..abstract_text> ..
- Mechanisms of acute bowel injury Role of NF-KBISABELLE DE PLAEN; Fiscal Year: 2008..This could prevent its progression toward irreversible intestinal damage and improve the survival of premature infants. [unreadable] [unreadable]..
- Gene Expression in Alzheimer's DiseaseWalter Lukiw; Fiscal Year: 2006..abstract_text> ..
- Role of PKR in Growth RegulationGlen Barber; Fiscal Year: 2008..We propose that these aims will lend insight into mechanisms of cell signaling, tumorigenesis and interferon-mediated actions in the cell. ..
- Functional synergism in prevention of hormone refractory CaP by phytochemicalsJoseph Wu; Fiscal Year: 2007..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. [unreadable] [unreadable] [unreadable]..
- Mast cells, antidepressants and chronic fatigue syndromeTheoharis Theoharides; Fiscal Year: 2007..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
- Cytokines and Mucosal Immune RegulationAveril Ma; Fiscal Year: 2006....
- Biophysiological Mechanisms of 'Heightened Speech'Katherine Verdolini; Fiscal Year: 2007..The primary dependent variable is quality of life in relation to voice, measured with the Voice Handicap Index. Secondary variables are aerodynamic, laryngeal, and vocal quality measures. [unreadable] [unreadable]..
- Mechanisms of Neutrophil-induced Liver ToxicityHartmut Jaeschke; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MOLECULAR IMMUNOLOGY OF MINOR HISTOCOMPATIBILITY ANTIGENSebastian Joyce; Fiscal Year: 2009..Additionally, the beneficial effects of graft-versus-leukemia, a by-product of GvHD, can be utilised as a therapy against cancers. ..
- Modest supplemental oxygen worsens lung injury in a murine model of sepsisNeil Aggarwal; Fiscal Year: 2008..This work has the potential to improve human outcomes and decrease burden on the health care system from this devastating illness. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Molecular Basis of iNKT Cell Ontogeny and FunctionSebastian Joyce; Fiscal Year: 2010..Additionally, this knowledge can lead to the development of therapeutics that either enhance (adjuvant effect, downregulate autoimmunity) or suppress (cerebral malaria, airway hypersensitivity) iNKT cell function. ..
- Mitochondrial Dysfunction and Drug HepatotoxicityHARTMUT W JAESCHKE; Fiscal Year: 2010..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
- Mechanisms of VSV-mediated OncolysisGlen N Barber; Fiscal Year: 2010..Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
- MECHANISMS OF EOSINOPHIL DEGRANULATION IN HUMAN DISEASEHirohito Kita; Fiscal Year: 2010..Relevance: Patients with asthma have persistent respiratory problems. This research will investigate how the interaction of immune cells and our environment cause and worsen the disease. ..
- Homeostasis of dendritic cells and GVHDMiriam Merad; Fiscal Year: 2010..These studies should provide valuable insights into LC regulation of skin immune responses and may lead to improved prevention or treatment of skin GVHD, a major medical problem in transplantation therapy of patients with malignancies. ..
- HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and TherapyShilpa J Buch; Fiscal Year: 2010..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..
- ETHANOL AND MAP KINASE CASCADESHIVENDRA SHUKLA; Fiscal Year: 2009..New knowledge gained from this project will facilitate development of therapeutic tools to prevent and control ethanol-induced cellular damage. ..
- Nitric oxide and mitochondrial biogenesis in sepsisClaude A Piantadosi; Fiscal Year: 2010..abstract_text> ..
- PHAGOCYTE RESOLVING METABOLISMCharles Serhan; Fiscal Year: 2009..abstract_text> ..
- Periodontitis, Anti-phospholipids, Dendritic Cells, and AtherosclerosisJohn Tew; Fiscal Year: 2009..A biological mechanism linking periodontitis and atherosclerosis would lend credibility to the epidemiological associations and help provide rationale for long-term longitudinal studies required to demonstrate causality. ..
- Cholestasis Prevention: Efficacy of IV Fish OilMark Puder; Fiscal Year: 2009..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..
- Uptake of apoptotic cellsPeter Henson; Fiscal Year: 2009..Approaches includeuse of knockout cells and animals, molecular modification, biochemistry and cell biology and an extensive collaborative network. ..
- Molecular Mechanisms Mediating NF-kB2/p100 ProcessingShao Cong Sun; Fiscal Year: 2007..abstract_text> ..
- Inflammatory Mechanisms of AtherosclerosisPeter Libby; Fiscal Year: 2006..5. We will explore a putative functional role of a novel prostaglandin E2 receptor EP4 interacting protein (EPRAP) in endogenous anti-inflammatory pathways. ..
- Hsp90 Mediates eNOS and Vascular FunctionKirkwood Pritchard; Fiscal Year: 2005..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
- MICROVASC OBSTRUCTION BY MRI AFTER CORONARY INTERVENTIONKatherine Wu; Fiscal Year: 2004..abstract_text> ..
- Cellular Activation Pathways in Rheumatoid ArthritisJoseph Holoshitz; Fiscal Year: 2004..The proposed studies will likely contribute significantly to understanding the pathogenesis of RA and, perhaps, other autoimmune diseases. ..
- TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAILDAVID BASILE; Fiscal Year: 2002..abstract_text> ..
- TEACHING NUTRITION TO PREVENT CARDIOVASCULAR DISEASESFrancine Welty; Fiscal Year: 2004..This career award will establish Dr. Walker as a leader in medical education in nutrition, his long-term career goal. ..
- Collectin-induced phagocytosis of apoptotic cellsPeter Henson; Fiscal Year: 2004..Finally, the role of collectins and calreticulin in removal of apoptotic cells and cell debris will be examined in the inflamed peritoneum and lung using inhibitors and knockout mice. ..
- Large Scale Images of Gene Transcription in MS and EAELawrence Steinman; Fiscal Year: 2004..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
- EXERCISE, STRESS AND IMMUNITY--PHYSIOLOGICAL MECHANISMSMonika Fleshner; Fiscal Year: 2004....
- INNATE IMMUNITY AND MYOCARDIAL INJURYGREGORY STAHL; Fiscal Year: 2003..abstract_text> ..
- Research Conference:Mutagenesis and CarcinogenesisLAWRENCE MARNETT; Fiscal Year: 2004..Leading scientists in the field will present and evaluate the latest research at the frontiers of mutagenesis and carcinogenesis. ..
- ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MSSubramaniam Sriram; Fiscal Year: 2002..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
- SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSISPaul Ridker; Fiscal Year: 2002....
- HDL Dysfunction and Vascular InflammationKirkwood A Pritchard; Fiscal Year: 2010..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
- IN VIVO TREATMENT OF EAE WITH ANTI I-A ANTIBODIESLawrence Steinman; Fiscal Year: 2001..Aim 5 is to assess the possibility of using DNA vaccination against TCR Vb for treatment of EAE. It is hoped that these studies will provide the basis for future clinical trials in MS patients. ..
- NIK KINASE AND T CELL COSTIMULATIONShao Cong Sun; Fiscal Year: 2003..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
- FGF-Silyl-Heparin Cerebral Aneurysm CoilsPAUL ZAMORA; Fiscal Year: 2002..The Phase I studies will develop the coated coils and perform initial animal evaluations. ..
- THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMENPaul Ridker; Fiscal Year: 2002....
- Native LDL, Cholesterol and Impaired VasodilationKirkwood Pritchard; Fiscal Year: 2006..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
- Kim-1 in Renal Epithelial Cell Motility and AdhesionBENJAMIN HUMPHREYS; Fiscal Year: 2005..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
- Latent Mobility Abnormalities and DisabilityJoe Verghese; Fiscal Year: 2006..unreadable] [unreadable]..
- Polarized DC as Melanoma Vaccine: Phase 1 EvaluationPawel Kalinski; Fiscal Year: 2006....
- PERSISTENT FETAL CELLS IN THE IMMUNOPATHOGENESIS OF SSCCarol Artlett; Fiscal Year: 2002..Obviously, the aims of this proposal cannot address the pathogenesis of SSc occurring in males, or in woman who have not had recognized pregnancies or male offspring. ..
- Regulatory CD4/CD8 T cells in autoimmune demyelinationVipin Kumar; Fiscal Year: 2006..perforin-/- mice. Knowledge of the immune principles involved here is important not only for understanding the biology of immune regulation but also in the design of TCR-based therapeutic approaches for autoimmune conditions in humans. ..
- Immune Regulation by A20Averil Ma; Fiscal Year: 2006..abstract_text> ..
- A Class II MHC-Associated Lymphocyte Activation DefectJoseph Holoshitz; Fiscal Year: 2006..These studies will examine a novel paradigm relevant to a physiologic regulatory mechanism in the immune system, whose perturbation may set the stage for immunopathology. ..
- REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTESMARY GOLDRING; Fiscal Year: 2001....
- Histone acetylation by ethanol:Mechanisms & consequenceSHIVENDRA SHUKLA; Fiscal Year: 2005..abstract_text> ..
- PAI-1 and The Vascular Toxicity of AldosteroneNancy Brown; Fiscal Year: 2005..This multi-disciplinary approach will generate new information regarding the role of aldosterone in vascular toxicity and, thus, improve our ability to prevent and treat cardiovascular disease. ..
- Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01W Michael Foster; Fiscal Year: 2010....
- RNA directed silencing of HIV and SIV receptorsMichael Murray; Fiscal Year: 2004..abstract_text> ..
- ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTIONChung Yang; Fiscal Year: 2007..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
- Granzyme a Pathway of CTL-Mediated Cell DeathJudy Lieberman; Fiscal Year: 2008..abstract_text> ..
- ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICSRICHARD ZAGER; Fiscal Year: 2001....
- MACROPHAGES, DENDRITIC CELLS AND PATHOGENSCarl Nathan; Fiscal Year: 2007..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..
- MYOCARDIAL INTEGRINS AND VENTRICULAR REMODELINGJOSEPH JANICKI; Fiscal Year: 2002....
- Endothelial reactivity and nitric oxide synthetase activity in the ALMS (AsprevaRobert Clancy; Fiscal Year: 2009..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
- REGULATION OF THE INNATE, IMMUNE RESPONSE BY IL-10Thomas Shanley; Fiscal Year: 2002..The information may identify a means to modulate pulmonary inflammation in patients and identify novel biologic effects of IL-10 on viral-mediated inflammatory responses. ..
- BEHAVIORAL AND IMMUNOLOGICAL FACTORS IN CORONARY DISEASEWillem Kop; Fiscal Year: 2005....
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- The Genetic Epidemiology of RA and SLELindsey Criswell; Fiscal Year: 2005..Criswell's ability to accomplish her goals as a patient-oriented clinical researcher and mentor through the provision of essential resources and relief of patient care and other activities. ..
- THE INFLAMMATORY RESPONSE OF THE PANCREATIC ACINAR CELLStephen Pandol; Fiscal Year: 2006..The results of the experiments described in the present application will allow us to propose how CCK, together with a cytokine modulating its effects, acts on the pancreatic acinar cell to cause experimental pancreatitis. ..
- AGE RELATED NEURODEGENERATIVE DISEASES IN MICRONESIADouglas Galasko; Fiscal Year: 2006..Subproject by Lee: 'PHF-tau in neurodegenerative diseases of Guam' will assess oxidative markers related to brain lesions in ALS, PDC and dementia. ..
- EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAINANNE FAGAN NIVEN; Fiscal Year: 2005..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
- Molecular and Cellular Analyses of Aquaporins in LungLANDON KING; Fiscal Year: 2005..These studies should provide insight into mechanisms regulating expression of AQP1 and AQP5, and establish a framework from which to better understand their role in the pathophysiology of the respiratory tract. ..