somatomedins

Summary

Summary: Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.

Top Publications

  1. ncbi Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors
    Kurt Zimmermann
    Bristol Myers Squibb Co, 5 Research Parkway, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 18:4075-80. 2008
  2. pmc Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
  3. ncbi Insulin and insulin-like growth factor signalling in neoplasia
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 8:915-28. 2008
  4. ncbi The somatomedin hypothesis: 2001
    D Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Rev 22:53-74. 2001
  5. ncbi The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways
    S A Coolican
    Biology Department, Syracuse University, Syracuse, New York 13244, USA
    J Biol Chem 272:6653-62. 1997
  6. ncbi Cellular actions of the insulin-like growth factor binding proteins
    Sue M Firth
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Endocr Rev 23:824-54. 2002
  7. pmc Defining the pathway to insulin-like growth factor system targeting in cancer
    Steven A Rosenzweig
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics and Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, PO Box 250505, Charleston, SC 29425 5050, USA
    Biochem Pharmacol 80:1115-24. 2010
  8. ncbi Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls
    Maria E Street
    Department of Pediatrics, University of Parma, Italy
    Eur J Endocrinol 155:567-74. 2006
  9. ncbi Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma
    P Cohen
    Department of Pediatrics, Stanford University Medical Center, California 94305
    J Clin Endocrinol Metab 75:1046-53. 1992
  10. ncbi The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003

Detail Information

Publications233 found, 100 shown here

  1. ncbi Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors
    Kurt Zimmermann
    Bristol Myers Squibb Co, 5 Research Parkway, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 18:4075-80. 2008
    ..The use of malonate as methyl anion synthon via S(N)Ar reaction and double decarboxylation under mild conditions is demonstrated...
  2. pmc Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
    ..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation...
  3. ncbi Insulin and insulin-like growth factor signalling in neoplasia
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 8:915-28. 2008
    ..Recent results are encouraging and have justified the expansion of many translational research programmes...
  4. ncbi The somatomedin hypothesis: 2001
    D Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Rev 22:53-74. 2001
    ..Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined...
  5. ncbi The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways
    S A Coolican
    Biology Department, Syracuse University, Syracuse, New York 13244, USA
    J Biol Chem 272:6653-62. 1997
    ..Thus, it appears that signaling from the IGF-I receptor utilizes two distinct pathways leading either to proliferation or differentiation...
  6. ncbi Cellular actions of the insulin-like growth factor binding proteins
    Sue M Firth
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Endocr Rev 23:824-54. 2002
    ..Because IGFBPs regulate cell functions by diverse mechanisms, manipulation of IGFBP-regulated pathways is speculated to offer therapeutic opportunities in cancer and other diseases...
  7. pmc Defining the pathway to insulin-like growth factor system targeting in cancer
    Steven A Rosenzweig
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics and Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, PO Box 250505, Charleston, SC 29425 5050, USA
    Biochem Pharmacol 80:1115-24. 2010
    ..In this commentary, we highlight some of the significant aspects of and prospects for targeting the IGF-1R and describe what the future may hold...
  8. ncbi Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls
    Maria E Street
    Department of Pediatrics, University of Parma, Italy
    Eur J Endocrinol 155:567-74. 2006
    ..It is unknown whether these occur in the placenta. The aim of this study was to assess whether interleukin-6 (IL-6) modulated the IGF system...
  9. ncbi Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma
    P Cohen
    Department of Pediatrics, Stanford University Medical Center, California 94305
    J Clin Endocrinol Metab 75:1046-53. 1992
    ..We speculate that PSA may serve to modulate IGF function within the reproductive system or in prostate cancer by altering IGF-IGFBP-3 interactions...
  10. ncbi The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ....
  11. ncbi Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro
    Toan Thang Phan
    National Burns Centre, Singapore General Hospital, Singapore 169608
    Am J Physiol Cell Physiol 284:C860-9. 2003
    ....
  12. ncbi The insulin-like growth factor system in cancer prevention: potential of dietary intervention strategies
    Dorien W Voskuil
    Division of Experimental Therapy, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:195-203. 2005
    ..On the short term, more research initiatives aimed at the effects of specific food components or dietary strategies on the IGF system both in animal models and in humans are warranted...
  13. ncbi Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions
    Cunming Duan
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 142:44-52. 2005
    ..In this article, we provide a brief overview of our current understanding of the IGF signaling system with particular reference to IGFBPs...
  14. ncbi Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
    Peter E Clayton
    Manchester Academic Health Sciences Centre, University of Manchester, Paediatric Endocrinology, Royal Manchester Children s Hospital, Oxford Road, Manchester, UK
    Nat Rev Endocrinol 7:11-24. 2011
    ..Nevertheless, long-term surveillance for cancer incidence in all populations exposed to increased levels of GH is vitally important...
  15. ncbi Interaction of IGF signaling and the androgen receptor in prostate cancer progression
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Cell Biochem 99:392-401. 2006
    ..Since fully humanized antibodies targeting the IGF-IR are now in clinical trials, the current review is intended to reveal the mechanisms of potential therapeutic effects of these antibodies on AI prostate cancers...
  16. ncbi IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis
    Stephen B Wheatcroft
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Trends Endocrinol Metab 20:153-62. 2009
    ..Here, we review the evolving roles of IGFBP-1 and IGFBP-2 in metabolic homeostasis, summarize their effects on IGF bioactivity and explore putative mechanisms by which they might exert IGF-independent cellular actions...
  17. ncbi Growth hormone and insulin-like growth factors in fish: where we are and where to go
    Manfred Reinecke
    Division of Neuroendocrinology, Institute of Anatomy, University of Zurich, CH 8057 Zurich, Switzerland
    Gen Comp Endocrinol 142:20-4. 2005
    ....
  18. ncbi JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    Meng C Wang
    Department of Biomedical Genetics, The Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, New York 14642, USA
    Cell 121:115-25. 2005
    ..The convergence of JNK signaling and IIS on Foxo provides a model to explain the effects of stress and nutrition on longevity...
  19. ncbi Insulin/IGF-like signalling, the central nervous system and aging
    Susan Broughton
    UCL Institute of Healthy Aging, GEE Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK
    Biochem J 418:1-12. 2009
    ..Tissue-specific manipulation of IIS and the cellular defence mechanisms that it regulates will better define the ways in which IIS affects neuronal and whole-organism function during aging...
  20. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
  21. ncbi Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    Sakiko Honjoh
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Nature 457:726-30. 2009
    ..These findings identify the essential role of signalling by RHEB-1 in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway...
  22. pmc Development temperature has persistent effects on muscle growth responses in gilthead sea bream
    Daniel García de la serrana
    Physiological and Evolutionary Genomics Laboratory, Scottish Oceans Institute, School of Biology, University of St Andrews, St Andrews, Scotland, UK
    PLoS ONE 7:e51884. 2012
    ..It was concluded that myogenesis and gene expression patterns during growth are not fixed, but can be modified by temperature during the early stages of the life cycle...
  23. pmc Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon
    Neil I Bower
    Scottish Oceans Institute, School of Biology, University of St Andrews, St Andrews, United Kingdom
    PLoS ONE 5:e11100. 2010
    ..A model depicting the transcriptional regulation of the IGF pathway in Atlantic salmon muscle following feeding is proposed...
  24. ncbi Insulin-like growth factors and neoplasia
    Michael N Pollak
    Department of Oncology, McGill University and Lady Davis Research Institute, 3999 Rue Côte Sainte Catherine, Montreal, Quebec H3T 1E2, Canada
    Nat Rev Cancer 4:505-18. 2004
  25. ncbi Associations of adiposity from childhood into adulthood with insulin resistance and the insulin-like growth factor system: 65-year follow-up of the Boyd Orr Cohort
    Richard M Martin
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, United Kingdom
    J Clin Endocrinol Metab 91:3287-95. 2006
    ..One metabolic pathway through which adiposity influences disease risk may be via alterations in insulin and IGF metabolism...
  26. pmc Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer
    Robert G Maki
    Memorial Sloan Kettering Cancer Center, New York, NY 10065 6007, USA
    J Clin Oncol 28:4985-95. 2010
    ..Greater success with these agents clinically is expected when combining the agents with inhibitors of other cell signaling pathways in which cross-resistance has been observed...
  27. ncbi Specifying the cellular responses to IGF signals: roles of IGF-binding proteins
    C Duan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109 1048, USA
    J Endocrinol 175:41-54. 2002
    ..A conceptual model of the molecular mechanisms by which IGFBPs act to determine the specific physiological outcomes of IGF stimulation is proposed and discussed...
  28. ncbi The IGF system
    Marta Annunziata
    Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, Turin, Italy
    Acta Diabetol 48:1-9. 2011
    ..The present review summarizes the main aspects of the IGF system biology and the interactions among IGF-I, insulin, insulin analogs and their receptors...
  29. ncbi A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    T M DeChiara
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Nature 345:78-80. 1990
    ..The effect of the mutation was exerted during the embryonic period. These results provide the first direct evidence for a physiological role of IGF-II in embryonic growth...
  30. pmc Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence
    Jianfeng Zhou
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e3926. 2008
    ..Elevated expression of IGFBP-2 is often associated with progression of many types of cancers...
  31. ncbi The insulin-like growth factor system and sarcomas
    Bart Rikhof
    Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, The Netherlands
    J Pathol 217:469-82. 2009
    ..Moreover, the occasional occurrence of paraneoplastic hypoglycaemia as a result of the secretion of incompletely processed forms of pro-IGF-II by sarcomas is discussed...
  32. pmc A Drosophila insulin-like peptide promotes growth during nonfeeding states
    Maija Slaidina
    Institute for Developmental Biology and Cancer, University of Nice Sophia Antipolis Centre National de la Recherche Scientifique, Parc Valrose, 06108 Nice, France
    Dev Cell 17:874-84. 2009
    ..This study reveals a specific class of ILPs induced upon metabolic stress that promotes growth in conditions of nutritional deprivation or following developmentally induced cessation of feeding...
  33. ncbi IGF system in cancer: from bench to clinic
    Jorge Chaves
    Yale University School of Medicine, USA
    Anticancer Drugs 22:206-12. 2011
    ..The researchers review the IGFs pathway and its implications in cancer development and treatment...
  34. pmc Targeting insulin-like growth factor axis in hepatocellular carcinoma
    Jennifer Wu
    Division of Hematology and Medical Oncology, NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    J Hematol Oncol 4:30. 2011
    ..IGF axis is increasingly recognized as one of the most relevant pathways in HCC and agents targeting this axis can potentially play an important role in the treatment of HCC...
  35. ncbi Associations of childhood and adulthood height and the components of height with insulin-like growth factor levels in adulthood: a 65-year follow-up of the Boyd Orr cohort
    Isabelle Bray
    Defence Analytical Services Agency Health, Spur 7, Beckford Block, Ensleigh, Bath BA1 5AB, United Kingdom
    J Clin Endocrinol Metab 91:1382-9. 2006
    ..Taller individuals with longer legs have a higher risk of cancer but a lower risk of coronary heart disease...
  36. ncbi Alcohol-induced disruption of endocrine signaling
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 31:1269-85. 2007
    ..Lang; (5) The role of reduced plasma estradiol and impaired estrogen signaling in alcohol-induced bone loss, by Martin J. Ronis; and (6) Short-term influence of alcohol on appetite-regulating hormones in man, by Jan Calissendorff...
  37. pmc The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    Tomoatsu Ikeya
    UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
    Proc Biol Sci 276:3799-807. 2009
    ..This effect of Wolbachia infection on IIS could have an evolutionary explanation, and has some implications for studies of IIS in Drosophila and other organisms that harbour endosymbionts...
  38. ncbi Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome?
    Wenjing Ruan
    Department of Pathology, School of Medicine, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, Zhejiang, China
    Acta Diabetol 47:5-14. 2010
    ..These exciting findings bring us new insight into the elucidation of the metabolic syndrome, which may have important clinical implications...
  39. ncbi Insulin like growth factor regulation of body mass in breastfed and milk formula fed infants. Data from the E.U. Childhood Obesity Programme
    P Socha
    Children Memorial, Health Institute, Warszawa, Poland
    Adv Exp Med Biol 569:159-63. 2005
  40. ncbi Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada
    Biol Reprod 76:571-8. 2007
    ..Igfbp5 gene was induced during postpartum involution. Our results suggest the importance of the IGF system in phenotypic and functional changes of myometrial SMCs throughout gestation in preparation for labor...
  41. ncbi Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain
    A Hoeflich
    Institute of Molecular Animal Breeding, Gene Center, Ludwig Maximilian University, Munich, Germany
    Endocrinology 140:5488-96. 1999
    ..05) lower in male transgenic than in control mice. Our data suggest that IGFBP-2 represents a negative regulator of postnatal growth in mice, potentially by reducing the bioavailability of IGF-I...
  42. ncbi Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human
    S Shimasaki
    Department of Molecular Endocrinology, Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037
    J Biol Chem 266:10646-53. 1991
    ....
  43. ncbi IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
    S Mohan
    Musculoskeletal Diseases Center, Jerry L Pettis VA Medical Center and Departments of Medicine, Biochemistry and Physiology, Loma Linda University, 11201 Benton Street, Loma Linda, California 92357, USA
    J Endocrinol 175:19-31. 2002
    ..One mechanism to account for such complexity with a relatively small number of genes is strikingly illustrated by the multifunctional IGFBP class of proteins...
  44. ncbi A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
    Naoki Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Cell 17:885-91. 2009
    ..These data indicate that DILP6 is a functional, as well as a structural, counterpart of vertebrate IGFs. Our data provide in vivo evidence for a role of ILPs in determining adult body size through the regulation of postfeeding growth...
  45. ncbi Regulation of embryo survival in cattle
    W W Thatcher
    Department of Animal Sciences, University of Florida, PO Box 110910, Gainesville, FL 32611 0910, USA
    Reprod Suppl 61:253-66. 2003
    ..1 mg deslorelin implant failed to reduce late embryonic losses when inserted on day 27 of pregnancy...
  46. ncbi Do height-related variations in insulin-like growth factors underlie the associations of stature with adult chronic disease?
    D Gunnell
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    J Clin Endocrinol Metab 89:213-8. 2004
    ..The associations of anthropometry with IGFBP-2 merit additional investigation...
  47. ncbi The consequences of insulin-like growth factors/receptors dysfunction in lung cancer
    Jasminka Pavelic
    Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, P Box 180, HR 10002 Zagreb, Croatia
    Am J Respir Cell Mol Biol 32:65-71. 2005
    ..The opposite was observed when the cells were treated with alphaIR3, which inhibits the activity of IGF-1 receptors. Our findings suggest that disruption of the IGF/IGF receptors axis is involved in lung cancer formation...
  48. ncbi IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
    Weidong Zhu
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Nature 454:345-9. 2008
    ..IGFBP-4 is therefore an inhibitor of the canonical Wnt signalling required for cardiogenesis and provides a molecular link between IGF signalling and Wnt signalling...
  49. ncbi The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    J Endocrinol 170:63-70. 2001
    ..This review provides an overview on the current knowledge of ALS protein and gene structure, organisation and regulation by hormones, and insights from novel animal models such as the ALS knockout mice...
  50. ncbi Signaling and function of insulin-like peptides in insects
    Qi Wu
    Department of Cellular Biology, University of Georgia, Athens
    Annu Rev Entomol 51:1-24. 2006
    ....
  51. ncbi Phosphorylation and regulation of Raf by Akt (protein kinase B)
    S Zimmermann
    Institute of Medical Virology, University of Zurich, Gloriastrasse 30 32, CH 8028 Zurich, Switzerland
    Science 286:1741-4. 1999
    ..These observations provide a molecular basis for cross talk between two signaling pathways at the level of Raf and Akt...
  52. ncbi The IGF axis and placental function. a mini review
    Karen Forbes
    Maternal and Foetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    Horm Res 69:129-37. 2008
    ....
  53. ncbi Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 10:89-109. 2006
    ....
  54. pmc Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily
    H S Kim
    Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Proc Natl Acad Sci U S A 94:12981-6. 1997
    ..These genes, along with those encoding the high-affinity IGFBPs 1-6, together constitute an IGFBP superfamily whose products function in IGF-dependent or IGF-independent modes to regulate normal and neoplastic cell growth...
  55. ncbi The insulin-like growth factors and feto-placental growth
    Abigail L Fowden
    Department of Physiology, University of Cambridge, CB2 3EG Cambridge, UK
    Placenta 24:803-12. 2003
    ..The Igf2gene appears to provide the constitutive drive for intrauterine growth via its placental effects and direct paracrine actions on fetal tissue while the Igf1gene regulates fetal growth in relation to the nutrient supply...
  56. ncbi Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction
    Sarah K Broughton
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Neurochem 100:628-38. 2007
    ....
  57. ncbi The insulin-like growth factor system: IGFs, IGF-binding proteins and IGFBP-proteases
    A Lelbach
    2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Acta Physiol Hung 92:97-107. 2005
    ..Besides their broad-spectrum physiological and pathophysiological functions, recent evidence suggests even a link between IGFs and different malignancies...
  58. ncbi Fetal programming of the growth hormone-insulin-like growth factor axis
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, Southampton University, South Academic Block Level D MP811, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:392-7. 2002
    ..Finally, there are data from both animals and humans suggesting that programming of the GH-IGF axis might exist...
  59. ncbi Fetal origins of adult disease: a paediatric perspective
    Harriet L Miles
    Liggins Institute, University of Auckland, Private Bag 92019, New Zealand
    Rev Endocr Metab Disord 6:261-8. 2005
    ..Future research in this field is likely to focus on the mechanisms through which environmental changes lead to these programmed effects...
  60. ncbi Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions
    L Jerome
    Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec, Canada H2W 1S6
    Endocr Relat Cancer 10:561-78. 2003
    ..A more comprehensive understanding of the interplay between cellular targets of the IGF system and antineoplastic agents will facilitate the development of novel strategies for the prevention and treatment of cancer...
  61. ncbi Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term
    Amanda N Sferruzzi-Perri
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia 5005
    Am J Physiol Endocrinol Metab 292:E668-76. 2007
    ..This was consistent with the previously observed increase in fetal growth and survival following IGF treatment...
  62. ncbi Silencing of endogenous IGFBP-5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma cells
    B Tanno
    ENEA Research Center Casaccia, Biotechnology Unit, Section of Toxicology and Biomedical Sciences, Via Angullarese, 301, 00060 S Maria di Galeria, Rome, Italy
    Cell Death Differ 12:213-23. 2005
    ..Together, these data demonstrate the importance of IGFBP-5 for NB cell functions and suggest that IGFBP-5 might serve as a novel therapeutic target in NB...
  63. ncbi Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
    A V Lee
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7884, USA
    Mol Endocrinol 13:787-96. 1999
    ..Taken together, these data not only reinforce the concept of cross-talk between IGF- and ER-signaling pathways, but indicate that IGF molecules may be critical regulators of estrogen-mediated growth and breast cancer pathogenesis...
  64. pmc Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis
    Mari Anne Rowlands
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Int J Cancer 124:2416-29. 2009
    ..Associations between IGFBP-3 and prostate cancer were inconsistent, and there was little evidence for a role of IGF-II, IGFBP-1 or IGFBP-2 in prostate cancer risk...
  65. ncbi IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo
    Gyanendra Tripathi
    Laboratory of Molecular Signalling, The Babraham Institute, Cambridge CB22 3AT, UK
    FASEB J 23:2616-26. 2009
    ..This study is also the first to suggest significant IGF-independent actions for IGFBP-5 during development...
  66. ncbi An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori
    Naoki Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    FEBS J 276:1221-32. 2009
    ..Our results also suggest that the known effects of ecdysteroid on insect adult development may be in part mediated by IGF-like peptides...
  67. pmc Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts
    J S Flier
    Proc Natl Acad Sci U S A 83:664-8. 1986
    ..By using this antibody, it is shown directly that insulin can act through the IGF-I receptor to stimulate DNA synthesis but can also activate this effect through the insulin receptor itself...
  68. pmc Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions
    W Kalus
    Max Planck Institute for Biochemistry, D 82152 Martinsried
    EMBO J 17:6558-72. 1998
    ..Compared with the full-length IGFBP-5, the smaller N-terminal fragments were less efficient inhibitors of the IGF-I receptor binding of IGFs...
  69. ncbi Endocrine regulation of aging and reproduction in Drosophila
    Janne M Toivonen
    Institute of Healthy Aging, UCL Research Department of Genetics, Environment and Evolution, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Mol Cell Endocrinol 299:39-50. 2009
    ..Here we shall review how major hormonal pathways in the fruit fly Drosophila melanogaster interact to influence reproductive capacity and aging...
  70. ncbi Insulin-like growth factor system regulates oligodendroglial cell behavior: therapeutic potential in CNS
    Daniel Chesik
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Mol Neurosci 35:81-90. 2008
    ..In the present review, we address these issues and consider current therapeutic prospects of oligodendrocyte-targeted IGF-based therapies...
  71. ncbi Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells
    I H L Hamelers
    Utrecht Graduate School of Developmental Biology, Department of Physiological Chemistry, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
    Endocr Relat Cancer 10:331-45. 2003
    ..Here, we review recent, often contradictory, reports describing the effects of E2 and IGFs on the proliferation of breast tumor cells, with special emphasis on the synergistic effects of the two hormones...
  72. pmc Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration
    Suzanne M de la Monte
    Department of Medicine and Pathology, Rhode Island Hospital and Warren Alpert School of Medicine at Brown University, Providence, Rhode Island 02903, USA
    Alcohol Clin Exp Res 32:1630-44. 2008
    ....
  73. ncbi Ethanol inhibits insulin expression and actions in the developing brain
    S M de la Monte
    Department of Pathology and Medicine, Pierre Galletti Research Building, Rhode Island Hospital, Providence, USA
    Cell Mol Life Sci 62:1131-45. 2005
    ..The results demonstrate that ethanol inhibits insulin-mediated actions in the developing brain by reducing local insulin production and insulin RTK activation, leading to inhibition of glucose transport and ATP production...
  74. ncbi Effects of genetic selection for milk yield on somatotropin, insulin-like growth factor-I, and placental lactogen in Holstein cows
    W J Weber
    Department of Animal Science, University of Minnesota, St Paul 55108 6118, USA
    J Dairy Sci 90:3314-25. 2007
    ..Results also indicate a positive relationship between PL and IGF-I and support the concept that PL plays a role in the regulation of serum IGF-I during gestation...
  75. ncbi Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling
    Susanne Buch
    Institute of Genetics, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Cell Metab 7:321-32. 2008
    ..tobi is thus a target of the insulin- and glucagon-like signaling system that responds oppositely to dietary protein and sugar...
  76. ncbi Detection of insulin-like growth factor binding proteins (IGFBPs) by ligand blotting in breast cancer tissues
    S E McGuire
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7884
    Cancer Lett 77:25-32. 1994
    ..IGFBP-4 was also inversely correlated with S-phase fraction. Thus, IGFBP expression correlates with other parameters of breast cancer biology and may play a role in regulating tumor growth...
  77. ncbi Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 280:16942-8. 2005
    ..This unique nongenotropic nuclear pathway supports an emerging role for IGFBP-3 as a novel, multicompartmental signaling molecule involved in induction of apoptosis in malignant cells...
  78. pmc Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
    James Beattie
    Hannah Research Institute, Ayr KA6 5HL, Scotland, UK
    Biochem J 395:1-19. 2006
    ..We also examine the regulation of IGFBP-5 expression and comment on its potential role in tumour biology, with special reference to work with breast cancer cells...
  79. ncbi Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5
    S V Allander
    Department of Clinical Genetics, Karolinska Institute, Stockholm, Sweden
    J Biol Chem 269:10891-8. 1994
    ....
  80. ncbi Switching to fast growth: the insulin-like growth factor (IGF) system in skeletal muscle of Atlantic salmon
    Neil I Bower
    Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Fife KY16 8LB, UK
    J Exp Biol 211:3859-70. 2008
    ..Together, these data show that switching to fast growth in Atlantic salmon skeletal muscle involves the local upregulation of IGF-I, IGFBP-5.2 and IGFBP-4, with downregulation of IGFBP-2.1...
  81. ncbi Effect of temperature on gene expression of the Gh/Igf system during embryonic development in rainbow trout (Oncorhynchus mykiss)
    Jean Charles Gabillard
    Equipe Croissance et Qualité de la Chair des Poissons, Station de Recherche Commune en Ichtyophysiologie, Biodiversité et Environnement SCRIBE INRA Campus Beaulieu, 35042 Rennes Cedex France
    J Exp Zool A Comp Exp Biol 298:134-42. 2003
    ..Before hatching, IGF-2 and both IGF receptors, but not IGF-1 mRNA, were specifically up-regulated by high temperatures and could be related to the enhancement of embryonic growth rate...
  82. ncbi Effect of refeeding on IGFI, IGFII, IGF receptors, FGF2, FGF6, and myostatin mRNA expression in rainbow trout myotomal muscle
    F Chauvigne
    Lab de Physiologie des Poissons, Scribe INRA, Campus de Beaulieu, 35042 Rennes Cedex, France
    Gen Comp Endocrinol 132:209-15. 2003
    ..In conclusion, among the potential growth factors we examined in this study, IGFI and FGF2 were identified as candidate genes whose expression may contribute to muscle compensatory growth induced by refeeding...
  83. ncbi The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule
    Yuichi Kamikubo
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:3297-306. 2006
    ..2004) Biochemistry 43, 6519] and that it binds specifically to mAb 153 via an interface that includes the three aromatic side chains previously implicated in binding to PAI-1...
  84. ncbi What is the role of circulating IGF-I?
    D Le Roith
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1758, USA
    Trends Endocrinol Metab 12:48-52. 2001
    ..Results gleaned from a mouse model created by tissue-specific gene deletion of liver IGF-I has enabled investigators to re-evaluate the original 'somatomedin hypothesis'...
  85. ncbi Comparative biology of the IGF system in endometrium, decidua, and placenta, and clinical implications for foetal growth and implantation disorders
    N R Nayak
    Department of Gynecology and Obstetrics, Center for Research on Women s Health and Reproductive Medicine, Stanford University Medical Center, Stanford, CA 94305 5317, USA
    Placenta 24:281-96. 2003
    ....
  86. ncbi The effect of maternal undernutrition on the placental growth trajectory and the uterine insulin-like growth factor axis in the pregnant ewe
    J C Osgerby
    Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, United Kingdom
    J Endocrinol 182:89-103. 2004
    ..Altered IGFBP expression may play a role in determining placental size in relation to nutritional status, but is unlikely to be the only mediator...
  87. ncbi The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers
    Louis D Payet
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:2382-9. 2004
    ..Our data suggest that pregnancy-proteolyzed IGFBP-3, despite forming normal ternary complexes, is less effective than intact IGFBP-3 in retarding IGF egress from the circulation...
  88. pmc Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival
    Peter J Schlueter
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 305:377-87. 2007
    ..Collectively, these data suggest a novel role for IGF signaling in early germline development, potentially via cross-talk with chemokine signaling pathways...
  89. pmc The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cell Cycle 7:2949-55. 2008
    ..We also discuss how the IGF pathway may provide additional molecular targets for the treatment of GISTs that respond poorly to IM therapy...
  90. ncbi Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells
    C M Perks
    Division of Surgery, Department of Hospital Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    J Cell Biochem 75:652-64. 1999
    ..05) reduced by IGFBP-5, whereas IGFBP-3 had no effect. These data provide evidence to suggest that individual IGFBPs have specific IGF-independent effects and act differentially on apoptotic signalling pathways...
  91. ncbi Role of the insulin-like growth factor family in cancer development and progression
    H Yu
    Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    J Natl Cancer Inst 92:1472-89. 2000
    ....
  92. ncbi Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women
    Erin J Aiello
    Center for Health Studies, Group Health Cooperative, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 14:1411-7. 2005
    ..Therefore, we evaluated the relationship of endogenous sex hormones, insulin-like growth factor (IGF), and lipids with mammographic density in 88 overweight, postmenopausal women not taking hormone therapy...
  93. ncbi Insulin and its receptor: structure, function and evolution
    Pierre De Meyts
    Receptor Biology Laboratory, Hagedorn Research Institute, Niels Steensens Vej 6, DK 2820 Gentofte, Denmark
    Bioessays 26:1351-62. 2004
    ....
  94. ncbi Kinetic analysis of the interaction between vitronectin and the urokinase receptor
    Yuushi Okumura
    Department of Cell Biology, Division of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:9395-404. 2002
    ..Inhibition of uPAR binding to VN by mAb 8E6 probably results from steric hindrance...
  95. pmc A deletion mutant of vitronectin lacking the somatomedin B domain exhibits residual plasminogen activator inhibitor-1-binding activity
    Christine R Schar
    Department of Biochemistry, Cellular, and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    J Biol Chem 283:10297-309. 2008
    ..These results support a model for the assembly of higher order PAI-1-vitronectin complexes via two distinct binding sites in both proteins...
  96. ncbi Discovery of a gonad-specific IGF subtype in teleost
    De Shou Wang
    Key Laboratory of Eco environments in Three Gorges Reservoir Region Ministry of Education, Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
    Biochem Biophys Res Commun 367:336-41. 2008
    ..These findings highlight the importance of this novel IGF in teleost gonadal development and reproduction...
  97. ncbi Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy
    M L Davenport
    Department of Pediatrics, Schools of Medicine, University of North Carolina, Chapel Hill 27599
    Endocrinology 127:1278-86. 1990
    ..The faster serum elimination half-life may result from diminished IGFBP-3, leading to greater IGF-I availability to tissues in pregnancy...
  98. pmc Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris
    Magnus Kjaergaard
    Finsen Laboratory, Rigshospitalet section 3735, Copenhagen Biocenter, DK 2200 Copenhagen N, Denmark
    Protein Sci 16:1934-45. 2007
    ..The NMR structure was determined for free SMB produced by Pichia and is largely consistent with that solved by X-ray crystallography for SMB in complex with PAI-1...
  99. ncbi Insulin-like growth factor signaling in fish
    Antony W Wood
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan Ann Arbor, Ann Arbor, Michigan 48109, USA
    Int Rev Cytol 243:215-85. 2005
    ..This review is intended as a summary of our understanding of IGF signaling, as revealed through research into the expression, function, and evolution of IGF ligands, receptors, and binding proteins in fish...
  100. ncbi Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows
    S Llewellyn
    Reproduction, Genes and Development Group, Royal Veterinary College, Hawshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Reproduction 133:627-39. 2007
    ....
  101. ncbi Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model
    Ariel C Cohen
    Department of Medicine, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 31:1558-73. 2007
    ....

Research Grants62

  1. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
  2. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..Knowledge gained from this study may also have application to other diseases across the age spectrum that are associated with bone loss and involve alterations in bone marrow composition. ..
  3. Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort Study
    Karen Bonuck; Fiscal Year: 2009
    ..If SDB has a significant temporal association with GF in our longitudinal, multivariable analysis, there are strong clinical practice implications for the screening, referral, and treatment of children with GF. ..
  4. Impact of exercise on ovarian cancer prognosis
    Melinda L Irwin; Fiscal Year: 2013
    ..abstract_text> ..
  5. Raf Kinase Inhibitory Protein (RKIP): A New Hepatocellular Carcinoma Tumor Suppre
    John M Sedivy; Fiscal Year: 2010
    ..The objective of this proposal is to develop mouse models of hepatocellular carcinoma in which this hypothesis can be directly tested. ..
  6. Rapamycin-induced Selective Apoptosis in Malignant Cells
    Peter J Houghton; Fiscal Year: 2012
    ..The studies have the potential to radically alter outcome for these children, and reduce the debilitating sequellae of high dose radiation and chemotherapy. ..
  7. Epidemiology and Incidence of Barrett's Esophagus
    DOUGLAS ALLEN CORLEY; Fiscal Year: 2010
    ..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
  8. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
    ..The results will advance the breast cancer field by characterizing the biological mechanism by which the metabolism of dietary omega-3 fatty acids is regulated by insulin-like growth factors to promote the growth of breast cancer. ..
  9. The Fetal and Childhood Environment, Oxidative Balance, Inflammation and Asthma
    Emily Oken; Fiscal Year: 2013
    ....
  10. Regulation of Retinal Cell Death in Diabetes
    Thomas W Gardner; Fiscal Year: 2013
    ..We will also determine the impact of insulin receptor/Akt signaling on retinal neuron survival and vision in diabetes using novel genetically modified mice. ..
  11. 2009 Insulin-like Growth Factors in Physiology and Disease Gordon Conference
    PETER S ROTWEIN; Fiscal Year: 2013
    ..abstract_text> ..
  12. Pre- and peri-natal predictors of childhood obesity
    Matthew W Gillman; Fiscal Year: 2013
    ..The results of this research will lead to new scientific knowledge about the drivers of growth and adiposity in childhood and may very well lead to new avenues for prevention of obesity, diabetes, and cardiovascular disease. ..
  13. DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
    Meir Stampfer; Fiscal Year: 2013
    ..abstract_text> ..
  14. Training in the Molecular Basis of Skin/Mucosa Parthobiology
    Molly F Kulesz-Martin; Fiscal Year: 2013
    ..5 million people in the US annually, ..
  15. INSULIN-LIKE GROWTH FACTORS AND MUSCLE DIFFERENTIATION
    PETER S ROTWEIN; Fiscal Year: 2012
    ..Major goals will be to define the mechanisms of action of this chromosomal response element. ..
  16. Role of STARD6 in ovarian steroidogenesis
    HOLLY ANNE LAVOIE; Fiscal Year: 2013
    ..Successful completion of this project will provide new insight into cholesterol trafficking for ovarian steroidogenesis and will serve as a basis for future studies of disorders of aberrant steroidogenesis by the ovary. ..
  17. TROPHIC MANIPULATIONS OF THE OCULOMOTOR SYSTEM
    Christopher S von Bartheld; Fiscal Year: 2010
    ....
  18. Regulation of insulin-like growth factors by the ER chaperone GRP94
    Yair Argon; Fiscal Year: 2013
    ..Together, these results will lead to a new understanding of how GRP94 chaperones client proteins. ..
  19. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    Stuart J Frank; Fiscal Year: 2013
    ..These insights have potential relevance to the endocrinology of growth and the behavior of human cancers. ..
  20. Intestinal Adaptation-Role of Hormones and Growth Factors
    Pauline K Lund; Fiscal Year: 2013
    ..Our findings will advance mechanistic understanding of the roles of IGF1R and IR in intestinal growth, stem cells and spontaneous or obesity-associated CRC ..
  21. Regulation of Lysolipid Signaling by Autotaxin-Integrin Interactions on Platelets
    ZACHARY FULKERSON; Fiscal Year: 2013
    ..It is therefore important to study further mechanisms by which platelets are regulated so that safer and more effective therapeutics might be developed. ..
  22. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  23. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..abstract_text> ..
  24. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ....
  25. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..abstract_text> ..
  26. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ....
  27. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..abstract_text> ..
  28. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    ..These antagonists could be used to block relaxin action during preterm labor as well as provide a tool for further research on the role of LGR7 and LGR8 in reproductive tract physiology. ..
  29. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2001
    ..B) Prostatic cancer cells treated with either control vehicle, testosterone, DHT, testosterone plus 5alpha-reductase inhibitors, and DHT plus 50:-reductase inhibitors. ..
  30. HORMONAL CONTROL OF GROWTH
    CHARLES NICOLL; Fiscal Year: 1992
    ..The possibility that hormones and GFs in milk support growth of suckling rat pups will also be studied...
  31. IGF Signalling, Apoptosis and Adenoma Risk
    PAULINE LUND; Fiscal Year: 2006
    ..LOI for IGF-II and IGF-II expression will be tested for associations with adenoma or apoptosis and for interactions with IRS-1 genotype or expression levels in predicting adenoma risk or apoptosis. ..
  32. RECEPTOR MECHANISMS OF IGF-II ACTION IN THE OVARY
    Leonid Poretsky; Fiscal Year: 1999
    ..This work may ultimately lead to the therapeutic use of IGF-II, its agonists or antagonists in anovulatory states or in other ovarian abnormalities. ..
  33. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  34. NEGATIVE REGULATION OF IGFBP-4 EXPRESSION IN BONE CELLS
    Xuezhong Qin; Fiscal Year: 1999
    ....
  35. Insulin-like Growth Factors & Esophageal Adenocarcinoma
    Thomas Vaughan; Fiscal Year: 2003
    ..abstract_text> ..
  36. IGF binding protein-3 in beta cell apoptosis
    ROBERT FERRY JR; Fiscal Year: 2005
    ....
  37. IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATION
    Stephen Rosenthal; Fiscal Year: 2002
    ....
  38. NUTRITION, INSULIN-LIKE GROWTH FACTORS AND FETAL GROWTH
    Marsha Davenport; Fiscal Year: 1990
    ..My studies will provide new information on regulation of somatomedins in the fetus and the role of the Sm/IGFs in fetal growth...
  39. MYOBLAST GROWTH AND DIFFERENTIATION DURING MUSCLE AGING
    Charlotte Peterson; Fiscal Year: 2000
    ..The feasibility of using IGFs as therapeutic agents to maintain muscle mass in the elderly can then be evaluated. ..
  40. INSULIN-LIKE GROWTH FACTOR SYSTEM IN OVIDUCT
    Linda Giudice; Fiscal Year: 1992
    ..In situ hybridization and immunohistochemical studies in whole tissue will confirm mRNA expression and protein synthesis, respectively, of the IGFs, their binding proteins and receptors, as well as define their cells of origin...
  41. Exercise effects on oxidative damage among women
    Cornelia Ulrich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. ROLE OF INSULIN-LIKE GROWTH FACTORS IN THE PNS
    Eva Feldman; Fiscal Year: 1993
    ..Our long term goal is to understand how the insulin-like growth factors regulate growth in the nervous system and to bridge the gap between receptor activation, signal induction and neurite outgrowth...
  43. IGFS AS REGULATORS OF ENDOCRINE CELL GROWTH & FUNCTION
    MITCHELL RABKIN; Fiscal Year: 1990
    ....
  44. CALORIC RESTRICTION IN TUMOR PROMOTION: MECHANISMS
    David Kritchevsky; Fiscal Year: 1991
    ..These studies will identify factors controlling mammary tumor growth during the promotion stage and may have significance for understanding basic biological control mechanisms through which diet can influence susceptibility to cancer...
  45. ESTROGEN AND INSULIN LIKE GROWTH FACTORS IN BREAST CANCE
    Herbert Yu; Fiscal Year: 2000
    ..We will also be able to further confirm our findings by expanding the study to the whole study population if the results are promising. ..
  46. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  47. BIOBEHAVIORAL FACTORS INFLUENCING WEIGHT IN ADOLESCENTS
    C Taylor; Fiscal Year: 1990
    ....
  48. HORMONAL EFFECTS ON GROWTH AND MATURATION
    MELVIN GRUMBACH; Fiscal Year: 1991
    ....
  49. INSULIN-LIKE GROWTH FACTORS IN THYROID PHYSIOLOGY
    Laura Bachrach; Fiscal Year: 1992
    ..Tissues from normal and experimentally-induced rats as well as human pathological thyroid specimens will be used to quantitate IGF binding, peptide concentration, and mRNA...
  50. IMPAIRED SOMATOMEDIN RESPONSIVENESS AND GROWTH FAILURE
    Stephen Rosenthal; Fiscal Year: 1990
    ..involved in the regulation of growth hormone (GH) and the GH-dependent insulin-like growth factors (IGFs) or somatomedins (Sm)...
  51. GROWTH FACTORS AND THEIR INHIBITORS IN RENAL FAILURE
    KENNETH GABBAY; Fiscal Year: 2000
    ..Understanding how IGFBP-3 and proteases interact to release IGFs may suggest new ways to liberate IGFs from IGFBP-3 in order to promote anabolic effects in a clinical setting. ..
  52. INSULIN AND HGH: SECRETION AND METABOLIC ACTIONS
    THOMAS MERIMEE; Fiscal Year: 1991
    ..To the Senior Investigator's knowledge there is no single laboratory in the United States with comparable capacity and a record that demonstrates this capacity...
  53. COMPARATIVE STUDIES OF SOMATOMEDIN AND INSULIN RECEPTORS
    Ron Rosenfeld; Fiscal Year: 1991
    The somatomedins are GH-dependent, insulin-like peptides with metabolic and mitogenic actions for a widely variety of cell lines...
  54. BIOLOGICAL ACTIVITY OF IGF AND FGF IN THE HUMAN PROSTATE
    SIMON HAYWARD; Fiscal Year: 2001
    ..Proteins will be localized by immunocytochemistry. The biological effects of the growth factors will be examined in vitro, using application of exogenous growth factors and blockade of their production and action. ..
  55. IGF AXIS ABNORMALITIES IN BPH
    Pinchas Cohen; Fiscal Year: 1999
    ..If successful , our findings may provide new targets for drug development and other novel therapeutic interventions or diagnostic strategies for use in men with BPH. ..
  56. PLASMA SOMATOMEDIN METABOLISM AND ACTIONS
    Raymond Hintz; Fiscal Year: 1991
    ..The long term objectives are to the clarify the hormonal control of the synthesis of the somatomedins, their prohormones and binding proteins, and to clarify the role of the somatomedins, their prohormones and ..
  57. ROLE OF INSULIN AND IGF IN OVARIAN FUNCTION
    Leonid Poretsky; Fiscal Year: 1992
    ..Better insights into these entities will hopefully lead to the development of more successful therapeutic regimens...
  58. IGFBP 4 PROTEASE AND HUMAN OSTEOBLASTS
    Xuezhong Qin; Fiscal Year: 2002
    ..Moreover, PR IGFBP-4 analog (if more potent than WT IGFBP-4) may have therapeutic potential in the treatment of IGF dependent cancers. ..
  59. Effect of exercise and weight loss on adipose tissue biology
    Anne McTiernan; Fiscal Year: 2009
    ..This information will allow us to develop better lifestyle recommendations on how to reduce cancer risk. ..
  60. INSULIN-LIKE GROWTH FACTOR II BIOLOGIC ACTIONS
    SAMUEL CASELLA; Fiscal Year: 1990
    The somatomedins/insulin-like growth factors (Sm/IGF) are a group of biologically active peptides that may be important in fetal development...
  61. AGING AND SOMATOMEDINS
    JAMES FLORINI; Fiscal Year: 1990
    ..deleterious effects of aging on several muscles and connective tissues result from decreases in levels of the somatomedins (SMs), a recently recognized family of insulin-like growth factors (IGF-I and IGF-II) that play a major ..
  62. SOMATOMEDIN C NOVEL REGULATOR OF GRANULOSA CELL FUNCTION
    Eli Adashi; Fiscal Year: 1990
    ....