platelet derived growth factor

Summary

Summary: Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.

Top Publications

  1. pmc Role of platelet-derived growth factors in physiology and medicine
    Johanna Andrae
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Genes Dev 22:1276-312. 2008
  2. ncbi Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
    Alan H Shih
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 64:4783-9. 2004
  3. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006
  4. pmc Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis
    M Pinzani
    Istituto di Medicina Interna Centro Interuniversitario di Fisiopatologia Epatica, Universita di Firenze, Italy
    Am J Pathol 148:785-800. 1996
  5. pmc Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity
    S Maudsley
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 20:8352-63. 2000
  6. ncbi Roles of PDGF in animal development
    Renée V Hoch
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 130:4769-84. 2003
  7. pmc PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    C Dai
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 15:1913-25. 2001
  8. ncbi Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma
    Max L Tejada
    Department of Molecular Oncology, Pathology, Genentech, Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 12:2676-88. 2006
  9. doi Platelet derived growth factor BB is a ligand for dermatan sulfate chain(s) of small matrix proteoglycans from normal and fibrosis affected fascia
    Ewa M Kozma
    Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Jednosci 8, 41 200 Sosnowiec, Poland
    Biochimie 91:1394-404. 2009
  10. doi Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
    Tadahiko Kubo
    Orthopedic Surgery Service, Memorial Sloan Kettering Cancer Center, Weil Medical College of Cornell University, New York, New York, USA
    Cancer 112:2119-29. 2008

Research Grants

  1. ENEIQUE A MESRI; Fiscal Year: 2016
  2. SATDARSHAN SINGH MONGA; Fiscal Year: 2016
  3. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
  4. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
  5. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
  6. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
  7. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
  8. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
  9. Wei Ding; Fiscal Year: 2015
  10. Latha Paka; Fiscal Year: 2014

Detail Information

Publications423 found, 100 shown here

  1. pmc Role of platelet-derived growth factors in physiology and medicine
    Johanna Andrae
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Genes Dev 22:1276-312. 2008
    ....
  2. ncbi Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
    Alan H Shih
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 64:4783-9. 2004
    ..Our data show that PDGFR signaling quantitatively regulates tumor grade and is required to sustain high-grade oligodendrogliomas...
  3. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006
    ..These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation...
  4. pmc Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis
    M Pinzani
    Istituto di Medicina Interna Centro Interuniversitario di Fisiopatologia Epatica, Universita di Firenze, Italy
    Am J Pathol 148:785-800. 1996
    ....
  5. pmc Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity
    S Maudsley
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 20:8352-63. 2000
    ....
  6. ncbi Roles of PDGF in animal development
    Renée V Hoch
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 130:4769-84. 2003
    ..elegans, Drosophila, Xenopus, zebrafish and mouse. Early data from these different systems suggest that some functions of PDGFs have been evolutionarily conserved...
  7. pmc PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    C Dai
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 15:1913-25. 2001
    ..Loss of Ink4a-Arf is not required for PDGF-induced glioma formation but promotes tumor progression toward a more malignant phenotype...
  8. ncbi Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma
    Max L Tejada
    Department of Molecular Oncology, Pathology, Genentech, Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 12:2676-88. 2006
    ..We propose that therapies targeting this stromal cell type may be effective in treating certain types of solid tumors...
  9. doi Platelet derived growth factor BB is a ligand for dermatan sulfate chain(s) of small matrix proteoglycans from normal and fibrosis affected fascia
    Ewa M Kozma
    Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Jednosci 8, 41 200 Sosnowiec, Poland
    Biochimie 91:1394-404. 2009
    Structural requirements of the short isoform of platelet derived growth factor BB (PDGF-BB) to bind dermatan sulfate (DS)/chondroitin sulfate (CS) are unknown...
  10. doi Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
    Tadahiko Kubo
    Orthopedic Surgery Service, Memorial Sloan Kettering Cancer Center, Weil Medical College of Cornell University, New York, New York, USA
    Cancer 112:2119-29. 2008
    ....
  11. pmc Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments
    Ian C Schneider
    Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
    Biophys J 86:599-608. 2004
    ..18 +/- 0.54 min(-1). In addition, we report that 3' PI turnover is not affected by PDGF receptor signaling in our cells, allowing us to focus our attention on the regulation of 3' PI production as this system is studied further...
  12. ncbi Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle
    L Karlsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:2611-21. 1999
    ..Such embryos fail to form pre-papilla aggregates of postmitotic PDGF-Ralpha-positive cells, suggesting that shh has a critical role in the assembly of the dermal papilla...
  13. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
    ....
  14. ncbi Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
    Barry L Eppley
    Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Plast Reconstr Surg 114:1502-8. 2004
    ..Sufficient concentrates and release of these growth factors through autologous platelet gels may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications...
  15. ncbi Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
    Marcela Assanah
    Department of Pathology, Columbia University, New York, New York 10032, USA
    J Neurosci 26:6781-90. 2006
    ....
  16. pmc Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation
    M M Kessels
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3202, USA
    Mol Biol Cell 11:393-412. 2000
    ..mAbp1 is a newly identified cytoskeletal protein in mice and may serve as a signal-responsive link between the dynamic cortical actin cytoskeleton and regions of membrane dynamics...
  17. ncbi The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    T F Franke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell 81:727-36. 1995
    ..These results identify Akt as a novel target of PI 3-kinase and suggest that the Akt PH domain may be a mediator of PI 3-kinase signaling...
  18. ncbi NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    J A Romashkova
    Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 27599 7280, USA
    Nature 401:86-90. 1999
    ..These findings establish a role for NF-kappaB in growth factor signalling and define an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-kappaB pathway, thus linking anti-apoptotic signalling with transcription machinery...
  19. ncbi A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated...
  20. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..Subsequent angiogenic sprouting and vessel enlargement involves PDGF-B-dependent vSMC/PC progenitor co-migration and proliferation, and/or PDGF-B-independent new induction of vSMC/PC, depending on tissue context...
  21. pmc A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells
    Eugene W Krueger
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Biol Cell 14:1085-96. 2003
    ....
  22. ncbi The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor
    W Yan
    Department of Stomatology, University of California, San Francisco 94143, USA
    J Biol Chem 276:31349-56. 2001
    ..These findings indicate that NIK acts downstream of platelet-derived growth factor receptors to phosphorylate and activate NHE1 divergently of its activation of JNK...
  23. ncbi Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development
    P Lindahl
    Department of Medical Biochemistry and Microbiology, University of Goteborg, Sweden
    Development 124:3943-53. 1997
    ..We also propose that postnatal alveogenesis failure in PDGF-A(-/-) mice is due to a prenatal block in the distal spreading of PDGF-Ralpha+ cells along the tubular lung epithelium during the canalicular stage of lung development...
  24. ncbi PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
    Erica L Jackson
    Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 51:187-99. 2006
    ..Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation...
  25. ncbi Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    T F Franke
    ABL Basic Research Program, National Cancer Institute Frederick Cancer Research Facility and Development Center NCI FCRFDC, Frederick, MD 21702, USA
    Science 275:665-8. 1997
    ..Thus, Akt is apparently regulated by the direct interaction of PtdIns-3,4-P2 with the Akt PH domain...
  26. doi PDGF receptor beta is a potent regulator of mesenchymal stromal cell function
    Ayano Tokunaga
    Department of Pathology, University of Toyama, Toyama, Japan
    J Bone Miner Res 23:1519-28. 2008
    ..The effects of PDGFRalpha on the osteogenic differentiation were very subtle. PDGFRbeta could represent an important target for guided tissue regeneration or tissue engineering of bone...
  27. ncbi PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts
    Linda Schneider
    Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, The August Krogh Building, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Curr Biol 15:1861-6. 2005
    ..We propose that ciliary PDGFRalphaalpha signaling is linked to tissue homeostasis and to mitogenic signaling pathways...
  28. ncbi Mechanism of action and in vivo role of platelet-derived growth factor
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden
    Physiol Rev 79:1283-316. 1999
    ..This review discusses structural and functional properties of PDGF and PDGF receptors, the mechanism whereby PDGF exerts its cellular effects, and the role of PDGF in normal and diseased tissues...
  29. pmc Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice
    L Gnessi
    Department of Medical Pathophysiology, University of Rome La Sapienza, 00161 Roma, Italy
    J Cell Biol 149:1019-26. 2000
    ..The Leydig cell loss and the spermatogenic impairment in the mutant mice are reminiscent of cases of testicular failure in man...
  30. pmc Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma
    Jean S Campbell
    Department of Pathology, University of Washington, Seattle, WA 98115, USA
    Proc Natl Acad Sci U S A 102:3389-94. 2005
    ..Moreover, PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis...
  31. pmc Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2209, USA
    J Control Release 112:103-10. 2006
    ..The successful generation of 3-D nano-fibrous scaffold incorporating controlled-release factors indicates significant potential for more complex tissue regeneration...
  32. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
    ..This study investigated if angiogenesis or growth factors or their receptors are associated with HIF-1alpha in invasive breast cancer...
  33. ncbi PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cancer Cell 6:333-45. 2004
    ..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis...
  34. ncbi Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease...
  35. ncbi Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
    Cancer Res 67:11377-85. 2007
    ..e., MMP-9 and VEGF), resulting in the inhibition of invasion and angiogenesis...
  36. pmc Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins
    M L Vignais
    Cold Spring Harbor Laboratory, New York 11724, USA
    Mol Cell Biol 16:1759-69. 1996
    ..These results suggests that the mechanism of JAK activation and JAK function in signaling differs between receptor tyrosine kinases and interferon receptors...
  37. ncbi PDGF and cardiovascular disease
    Elaine W Raines
    Department of Pathology, Harborview Medical Center, University of Washington, Box 359675, 325 9th Avenue, Seattle, WA 98104, USA
    Cytokine Growth Factor Rev 15:237-54. 2004
    ..Other activities of PDGF identified in vivo suggest additional functions for PDGF in the pathogenesis of cardiovascular disease...
  38. pmc Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells
    Carolyn V Ustach
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 E Canfield, Detroit, Michigan 48201, USA
    Mol Cell Biol 25:6279-88. 2005
    ..This evidence provides a direct link between uPA- and PDGF D-mediated cell signaling, which may contribute to the progression of prostate cancer...
  39. pmc Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 21:6387-94. 2001
    ..In conclusion, our data demonstrate that the PDGFbetaR and the EGFR form PDGFbetaR-EGFR heterodimers basally, and we suggest that heterodimers represent a novel signaling complex which plays an important role in PDGF signal transduction...
  40. ncbi Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis
    Jean S Campbell
    Department of Pathology, University of Washington School of Medicine, Box 357705, Seattle, WA 98195, USA
    Differentiation 75:843-52. 2007
    ..Our findings suggest that imatinib may be efficacious in the treatment of hepatocarcinogenesis, particularly when neovascularization is present...
  41. pmc miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Stem Cells 27:1712-21. 2009
    ....
  42. ncbi Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis
    Weisheng V Chen
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Genet 36:304-12. 2004
    ..The same platform can be used to search for genes of specific biological relevance in a broad array of experimental settings, providing a fast track from gene identification to functional validation...
  43. doi PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and o
    Felicia Ng
    Genome and Gene Expression Analysis Group, Bioinformatics Institute, Agency for Science Technology and Research A STAR, Singapore
    Blood 112:295-307. 2008
    ..Thus, this study illustrates it is possible to predict signaling pathways active in cellular differentiation and growth using microarray data and experimentally verify these predictions...
  44. ncbi Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: regulation of c-fos AND p27(kip1) gene expression
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Biol Chem 276:35636-43. 2001
    ....
  45. ncbi Regulation of PDGF and its receptors in fibrotic diseases
    James C Bonner
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cytokine Growth Factor Rev 15:255-73. 2004
    ..This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin...
  46. ncbi Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571
    Eric C McGary
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Clin Cancer Res 8:3584-91. 2002
    ..It has been reported previously that STI571 has specific activity in inhibiting select tyrosine kinase receptors, including PDGF and c-Kit. Osteosarcomas express low levels of c-Kit but abundant levels of PDGF receptor (PDGFR)...
  47. ncbi Platelet gel for healing cutaneous chronic wounds
    Giovanni Crovetti
    Servizio di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliera Ospedale di Circolo di Busto Arsizio Ple Solaro 3, 21052 Busto Arsizio, Varese, Italy
    Transfus Apher Sci 30:145-51. 2004
    ..wound healing platelets play an essential role since they are rich of alpha-granules growth factors (platelet derived growth factor--PDGF; transforming growth factor-beta--TGF-beta; vascular endothelial growth factor--VEGF)...
  48. pmc Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins
    B P Liu
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Mol Cell Biol 20:7160-9. 2000
    ..Expression of a carboxy-terminal fragment of Vav2 decreased the elevation of Rac1 activity induced by epidermal growth factor, consistent with Vav2 mediating activation of Rac1 downstream from growth factor receptors...
  49. pmc Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass
    Orion D Weiner
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue C 1, 502, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:196-202. 2002
    ..Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils...
  50. ncbi Growth factors in the treatment of diabetic foot ulcers
    S P Bennett
    Unit of Cell and Molecular Biology, The Dental School, University of Dundee, Dundee, UK
    Br J Surg 90:133-46. 2003
    ..These wounds may benefit from molecular manipulation of growth factors to enhance the microcirculation...
  51. doi Platelet derived growth factor-AB enhances knee meniscal cell activity in vitro
    Nezar S Tumia
    Department of Orthopaedic Surgery, Queen Elizabeth Hospital, Gateshead, NE 9 6SX, UK
    Knee 16:73-6. 2009
    ..In this study we investigated the potential for platelet derived growth factor-AB (PDGF-AB) to promote meniscal tissue regeneration in the inner (avascular), middle, and outer (..
  52. ncbi Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
    Alexander Beeser
    Tumor Cell Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 280:36609-15. 2005
    ..These findings suggest that Paks are required for the phosphorylation of c-Raf at Ser(338) in response to either growth factor, but that the mechanisms by which EGF and PDGF activate c-Raf are fundamentally different...
  53. ncbi Platelet-derived growth factor receptor signals
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    J Biol Chem 269:32023-6. 1994
  54. doi Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells
    Dong Woo Kang
    Department of Molecular Biology, College of Natural Science, Pusan National University, 30 Jangjeon dong, Busan, Republic of Korea
    Cancer Lett 294:125-33. 2010
    ..Here we investigate that platelet derived growth factor (PDGF) increases PLD1 but not PLD2 expression via Ras-ERK/PI3K-NFkappaB signaling cascade in SK-BR3 ..
  55. pmc Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis
    M Kolb
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 107:1529-36. 2001
    ..IL-1beta should be considered a valid target for therapeutic intervention in diseases associated with fibrosis and tissue remodeling...
  56. pmc MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation
    Yunhui Cheng
    Department of Anesthesiology, New Jersey Medical School, UMDNJ, 185 South Orange Ave, MSB E548, Newark, NJ 07101, USA
    Circ Res 105:158-66. 2009
    ..These novel findings may have extensive implications for the diagnosis and therapy of a variety of proliferative vascular diseases...
  57. ncbi PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor
    E Bergsten
    Ludwig Institute for Cancer Research, Stockholm Branch, PO Box 240, S 171 77 Stockholm, Sweden
    Nat Cell Biol 3:512-6. 2001
    ..PDGF-DD is the first known PDGFR-beta-specific ligand, and its unique receptor specificity indicates that it may be important for development and pathophysiology in several organs...
  58. pmc Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
    Amir Abdollahi
    Department of Radiation Oncology, German Cancer Research Center, Heidelberg 69120, Germany
    J Exp Med 201:925-35. 2005
    ..This study points the way to a potential new approach for treating idiopathic or therapy-related forms of lung fibrosis...
  59. ncbi Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
    P Rodriguez-Viciana
    Imperial Cancer Research Fund, London, United Kingdom
    Cell 89:457-67. 1997
    ..The ability of activated Ras to stimulate PI 3-kinase in addition to Raf is therefore important in Ras transformation of mammalian cells and essential in Ras-induced cytoskeletal reorganization...
  60. ncbi Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers
    D J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Diabetes Care 24:483-8. 2001
    ....
  61. ncbi Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathy
    Keisuke Mori
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Invest Ophthalmol Vis Sci 43:2001-6. 2002
    ..This study was undertaken to determine whether higher levels of endogenously produced PDGF-A in the retinas of mice result in retinal detachment...
  62. ncbi SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma
    Anders Kallin
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Experimental Medicine Unit, Brussels, Belgium
    J Lipid Res 48:1628-36. 2007
    ..In conclusion, our data suggest that SREBP-1 regulates the expression of stress response and signaling genes, which could contribute to the metabolic response to insulin and growth factors in various tissues...
  63. ncbi LRP: role in vascular wall integrity and protection from atherosclerosis
    Philippe Boucher
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 300:329-32. 2003
    ..Thus, LRP1 has a pivotal role in protecting vascular wall integrity and preventing atherosclerosis by controlling PDGFR activation...
  64. ncbi Inhibitor of apoptosis protein survivin regulates vascular injury
    Olivier P Blanc-Brude
    Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 8:987-94. 2002
    ..These data identify survivin as a critical regulator of SMC apoptosis after acute vascular injury. Disrupting the survivin pathway may provide a novel therapy to limit pathological vessel-wall remodeling...
  65. ncbi Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase
    Y S Bae
    Center for Cell Signaling Research, Division of Molecular Life Sciences, and Department of Biological Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 275:10527-31. 2000
    ..These results suggest that a product of PI3K is required for PDGF-induced production of H(2)O(2) in nonphagocytic cells, and that Rac1 mediates signaling between the PI3K product and the putative NADPH oxidase...
  66. ncbi Platelet-derived growth factor receptors: a therapeutic target in solid tumors
    D George
    Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Semin Oncol 28:27-33. 2001
    ....
  67. ncbi Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model
    Göran Hesselager
    Department of Genetics and Pathology, Rudbeck Laboratory, University Hospital, SE 75185 Uppsala, Sweden
    Cancer Res 63:4305-9. 2003
    ....
  68. pmc PDGF receptors are activated in human epiretinal membranes
    Jing Cui
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Exp Eye Res 88:438-44. 2009
    ..These findings identify PDGF-A, -AB and C as the best therapeutic targets within the PDGF family...
  69. ncbi Interaction of the Nck adapter protein with p21-activated kinase (PAK1)
    G M Bokoch
    Department of Immunology and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:25746-9. 1996
    ..The interaction of active PAK1 with Nck leads to the phosphorylation of Nck at multiple sites. Association of Nck with PAK1 may serve to link this important regulatory kinase to cell activation by growth factor receptors...
  70. pmc Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
    Ian C Schneider
    Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
    J Cell Biol 171:883-92. 2005
    ....
  71. pmc Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor
    G W Hoyle
    Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Department of Medicine, Tulane University, New Orleans, Louisiana, USA
    Am J Pathol 154:1763-75. 1999
    ..Results of these studies indicated that overexpression of PDGF-B induced distinct abnormalities in the developing and adult lung and led to a complex phenotype that encompassed aspects of both emphysema and fibrotic lung disease...
  72. ncbi A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair
    M B Schmidt
    Schmidt Technical Consulting, LLC, 7 Amberg Drive, Pomfret Center, CT 06259, USA
    Osteoarthritis Cartilage 14:403-12. 2006
    ..Two growth factors that have been studied in cartilage repair are insulin-like growth factor (IGF) and platelet derived growth factor (PDGF). IGF plays a key role in cartilage homeostasis, balancing proteoglycan synthesis and breakdown...
  73. ncbi Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes
    Frederic Dandre
    Cardiovascular Research Center, University of Virginia, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Am J Physiol Heart Circ Physiol 286:H2042-51. 2004
    ..Taken together, results of these experiments provide novel insights regarding possible mechanisms whereby PDGF-BB and Ets-1 may contribute to SMC phenotypic switching associated with vascular injury...
  74. ncbi Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
    T Matsui
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Science 243:800-4. 1989
    ..The existence of genes encoding two PDGF receptors that interact in a distinct manner with three different PDGF isoforms likely confers considerable regulatory flexibility in the functional responses to PDGF...
  75. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
    ..We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney...
  76. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
  77. ncbi A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration
    Marianne F James
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Cell Sci 117:2951-61. 2004
    ..Thus, the interaction of betaPDGFR with NHERF may provide an essential link between the cell membrane and the cortical actin cytoskeleton independent of receptor activity...
  78. ncbi New members of the platelet-derived growth factor family of mitogens
    Carl Henrik Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, SE 751 24, Sweden
    Arch Biochem Biophys 398:284-90. 2002
  79. ncbi Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers
    David L Steed
    Department of Surgery, University of Pittsburgh, UPMC Presbyterian Hospital, Pittsburgh, PA 15213, USA
    Plast Reconstr Surg 117:143S-149S; discussion 150S-151S. 2006
    ..Diabetic foot ulcer is a major health care problem that leads to amputation...
  80. doi Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas
    Oren J Becher
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Res 68:2241-9. 2008
    ..Lastly, we observe that SHH is similarly expressed in human gliomas and note that an intact tumor microenvironment or neurosphere conditions in vitro are required for Gli activity...
  81. pmc Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
    T Bowman
    Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Proc Natl Acad Sci U S A 98:7319-24. 2001
    ..These findings, combined together, delineate the signaling pathway, PDGF --> Src --> Stat3 --> Myc, that is important in normal PDGF-induced mitogenesis and subverted in Src transformation...
  82. ncbi PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    X Li
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Nat Cell Biol 2:302-9. 2000
    ....
  83. ncbi PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
    H Bostrom
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Cell 85:863-73. 1996
    ..The two PDGF null phenotypes also reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis...
  84. ncbi PDGF signaling in cells and mice
    Michelle Tallquist
    Deptartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cytokine Growth Factor Rev 15:205-13. 2004
    ..More recently, PDGF signaling has also been investigated in mice. This review outlines the advances in these two systems, and highlights some of the directions for future investigation...
  85. ncbi Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells
    Huey Ming Lo
    School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan
    Biochem Pharmacol 74:54-63. 2007
    ..The results presented here may help us to better understand the beneficial effects of lycopene in CVD prevention...
  86. ncbi Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation
    Irina Kratchmarova
    Center for Experimental Bioinformatics CEBI, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Science 308:1472-7. 2005
    ..Thus, quantitative proteomics can directly compare entire signaling networks and discover critical differences capable of changing cell fate...
  87. ncbi Polymeric system for dual growth factor delivery
    T P Richardson
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Nat Biotechnol 19:1029-34. 2001
    ..This is the first report of a vehicle capable of delivery of multiple angiogenic factors with distinct kinetics, and these results clearly indicate the importance of multiple growth factor action in tissue regeneration and engineering...
  88. ncbi Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage
    J B Grinspan
    Department of Neurology Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurobiol 43:1-17. 2000
    ..These data suggest that as cells progress through the oligodendrocyte lineage, they show developmentally restricted responses to the BMPs...
  89. ncbi Weekly dosing with the platelet-derived growth factor receptor tyrosine kinase inhibitor SU9518 significantly inhibits arterial stenosis
    Y Yamasaki
    Taiho Pharmaceutical Co, Ltd, Hanno Research Center, Saitama, Japan
    Circ Res 88:630-6. 2001
    ..32 versus 1.34+/-0.45 [P<0.01], respectively). These studies provide the rationale to evaluate PDGF receptor tyrosine kinase inhibitors, including inhibitors related to the indolinone, SU9518, for the treatment of arterial restenosis...
  90. pmc Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Stem Cells 26:1425-35. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  91. ncbi The gene expression profile of PDGF-treated neural stem cells corresponds to partially differentiated neurons and glia
    Jean Baptiste Demoulin
    MEXP Unit, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Growth Factors 24:184-96. 2006
    ..Finally, the transcriptional signature of stem cells grown with FGF-2 included a large number of genes over-expressed in gliomas and a core set of conserved genes periodically expressed during the eukaryote cell cycle...
  92. ncbi Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    Ralf Erber
    Department of Neurosurgery, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    FASEB J 18:338-40. 2004
    ....
  93. pmc Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    Gabriele Bergers
    Department of Neurological Surgery, University of California, San Francisco Comprehensive Cancer Center, San Francisco, San Francisco, California 94115, USA
    J Clin Invest 111:1287-95. 2003
    ..Thus, combinatorial targeting of receptor tyrosine kinases shows promise for treating multiple stages in tumorigenesis, most notably the often-intractable late-stage solid tumor...
  94. ncbi PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse
    R L Brown
    Shriners Burns Institute, Cincinnati, Ohio 45229
    J Surg Res 56:562-70. 1994
    ..The PDGF-BB/TGF-alpha combination accelerated healing in the diabetic animals to a rate that was closer to that seen in nondiabetic mice.(ABSTRACT TRUNCATED AT 250 WORDS)..
  95. ncbi Transcription of the platelet-derived growth factor A-chain gene
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0084, USA
    Cytokine Growth Factor Rev 14:427-46. 2003
    ....
  96. ncbi Platelet derived growth factor (PDGF)-induced reactive oxygen species in the lens epithelial cells: the redox signaling
    Kate Chao Wei Chen
    Department of Biochemistry, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Exp Eye Res 78:1057-67. 2004
    ..It is proposed that the physiological function of ROS, the redox signaling, is present in the HLE cells and may play an important role in the development and maintenance of the lens...
  97. ncbi PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine
    S Banai
    Heiden Department of Cardiology, Bikur Cholim Hospital, Jerusalem, Israel
    Circulation 97:1960-9. 1998
    ....
  98. pmc c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis
    Olivia Furstoss
    CNRS UPR 1086 CRBM, 1919 Route de Mende, F 34293 Montpellier, France
    EMBO J 21:514-24. 2002
    ....
  99. pmc Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)
    Yuhui Liu
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    EMBO J 26:4683-93. 2007
    ..These genetic results suggest that p21 acts through the cyclin D1-cdk4 complex to support tumor growth, and establish the utility of using a somatic cell modeling system for defining the contribution proteins make to tumor development...
  100. ncbi Gene expression of profibrotic mediators in bronchiolitis obliterans syndrome after lung transplantation
    M Bergmann
    Department of Internal Medicine, University of Kiel, Germany
    Scand Cardiovasc J 32:97-103. 1998
    ..The data were consistent with the hypothesis based mainly on in vitro findings that PDGF and TGF-beta contribute to the development of BOS...
  101. ncbi Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta)
    Yoshiharu Takayama
    Departments of Molecular Genetics and Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 280:18504-10. 2005
    ..Thus, LRP1 modulates PDGF signaling by controlling ubiquitination and endocytosis of the PDGFRbeta...

Research Grants76

  1. ENEIQUE A MESRI; Fiscal Year: 2016
    ..NAC inibited VEGF, c-myc and viral gene expression in the mECK36 tumors through a mechanism involving platelet derived growth factor (PDGF) receptor and ligand downregulation...
  2. SATDARSHAN SINGH MONGA; Fiscal Year: 2016
    ..present grant is focused on understanding the role of a lesser known molecule in hepatocyte biology, platelet derived growth factor receptor-alpha (PDGFR[unreadable]) based on some intriguing observations made over last several years...
  3. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..Increased expression of both platelet derived growth factor (PDGF) and its receptors (PDGFR1 and PDGFR2) have been demonstrated in skin of scleroderma patients...
  4. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ....
  5. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..This work should hold important benefits for treating congenital craniofacial defects. ..
  6. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..abstract_text> ..
  7. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..This alarming observation raises the possibility that carbon nanotubes could pose a serious threat to human health and the environment. ..
  8. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..In addition, the results will fundamentally advance the field of cardio-pulmonary vascular research in general. ..
  9. Wei Ding; Fiscal Year: 2015
    ..Our data indicates that platelet derived growth factor (PDGF) secreted by CLL B-cells modulates stromal cell proliferation and subsequent vascular ..
  10. Latha Paka; Fiscal Year: 2014
    ..Increased expression of both platelet derived growth factor (PDGF) and its receptors (PDGFR? and PDGFR?) have been demonstrated in skin of scleroderma patients...
  11. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ..Vascular endothelial growth factor, platelet derived growth factor, connective tissue growth factor, and transforming growth factor beta are among hundreds of ..
  12. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..Washburn Therapeutics Inc. is developing a novel gel that inhibits the fundamental biochemical factors that sustain non-healing wounds and promotes healing. ..
  13. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..This study will investigate the function of recently discovered sulfatase enzymes that enhance growth of liver cancers, with the goal of developing effective treatments for this devastating disease. ..
  14. Lakshman Segar; Fiscal Year: 2015
    ..Strategies to inhibit PDGF receptor signaling may prevent dysregulated glucose metabolism and insulin signaling to improve vascular function in nondiabetic and diabetic patients. ..
  15. ELUCIDATING THE FUNCTION OF MATRIPTASE-ACTIVATED PDGF D IN BONE METASTATIC PROSTA
    ABDO JAMAL NAJY; Fiscal Year: 2012
    ..Concomitantly, we envision our salient contributions leading to the development of novel and targeted therapeutics for prostate cancer in addition to improving the efficacy of existing treatment modalities. ..
  16. Ovarian hormone suppression and regulation of adipogenesis in women
    Wendy M Kohrt; Fiscal Year: 2012
    ..Thus, identifying strategies that effectively prevent an increase in adipogenesis during ovarian hormone withdrawal would be of high clinical importance. ..
  17. Golam Mohi; Fiscal Year: 2016
    ..The results of these studies may identify new therapeutic targets for MPDs. Moreover, our inducible JAK2V617F knock-in mouse will provide a unique and reproducible animal model to test novel therapies for JAK2V617F-associated MPDs. ..
  18. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
  19. Oxidant signaling for airway remodeling and inflammation
    YUICHIRO JUSTIN SUZUKI; Fiscal Year: 2012
    ..In addition, the results will fundamentally advance the field of lung cell biology. (End of Abstract) ..
  20. ERIKA HEIDI NOSS; Fiscal Year: 2016
    ....
  21. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
    ..These abundant glial cells express the alpha receptor for platelet derived growth factor (PDGF1R), and the chondroitin sulfate proteoglycan NG2, and have been termed "NG2+ glial cells (NG2 ..
  22. PDGFR and KDR Inhibitors for Liver Fibrosis
    Bert Oehlen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Small molecule dual inhibitors of the PDGFR and KDR receptors are potential therapeutics for fibrotic disease in the liver, as well as other major organs. ..
  23. Transcriptional Regulation of PDGF Receptor Alpha
    Jane Reusch; Fiscal Year: 2009
    ..Determine how PDGFRa expression is affected by changing concentrations and activation states of CREB and C/EBPdelta. 3. To determine whether PPARa mediated suppression of PDGFRa gene expression works through CREB and C/EBPs. ..
  24. Hyeong Reh Choi Kim; Fiscal Year: 2016
    ....
  25. Micromagnetic Aptamer PCR System for Ultrasensitive Multiplexed Protein Detection
    HYONGSOK TOM SOH; Fiscal Year: 2010
    ..As a model system we will demonstrate simultaneous detection of three cancer markers, platelet derived growth factor (PDGF), hepatocyte growth factor (HGF), and thyroid transcription factor (TTF1), at femtomolar ..
  26. CHRISTOPHER KANE BREUER; Fiscal Year: 2016
    ..Subsequently, these macrophages recruit smooth muscle cells from the adjacent vessel wall through a platelet derived growth factor (PDGF)-dependent mechanism and endothelial cells via a vascular endothelial growth factor (VEGF)-..
  27. Kathy K Griendling; Fiscal Year: 2014
    ..Understanding the mechanisms underlying migration may lead to the development of new therapeutic strategies that can be carefully and specifically targeted to the critically important events in disease initiation. ..
  28. JONATHAN A SOBOLOFF; Fiscal Year: 2015
    ..Considered in combination, these investigations will provide the framework for a new understanding of how Ca2+ signals in cells are modulated over extended time periods via crosstalk between autocrine, paracrine and endocrine factors. ..
  29. Morphogenesis of the pulmonary artery smooth muscle layer
    Daniel Greif; Fiscal Year: 2012
    ..b>Platelet derived growth factor (PDGF)-induced signaling has been implicated in the pathogenesis of pulmonary artery hypertension and ..
  30. Rosalyn M Adam; Fiscal Year: 2016
    ..We anticipate this analysis will shed new light on fundamental mechanisms underlying bladder muscle physiology and may also provide insight into new treatment strategies. ..
  31. Goutam Ghosh Choudhury; Fiscal Year: 2016
    ....
  32. Akiko Hata; Fiscal Year: 2016
    ..Aberrant expression and activation of the platelet derived growth factor (PDGF) signaling pathway are identified in the medial layer of the remodeled pulmonary arteries (PAs) ..
  33. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..abstract_text> ..
  34. Regulation of glioblastoma migration by PTEN PDZ-binding domain
    Andrew M Chan; Fiscal Year: 2010
    ..The long-term goal is to use this mouse model as a drug discovery tool to identify compounds that can block the spread of human glioblastoma. ..
  35. Analysis of PDFR alpha signaling in cardiac fibroblast development and function
    Christopher L Smith; Fiscal Year: 2012
    ..b>Platelet derived growth factor receptors (PDGFR) are receptor tyrosine kinases that provide signals important for fibroblast ..
  36. Bone marrow-derived fibroblasts in skin wound healing
    Omaida C Velazquez; Fiscal Year: 2010
    ..abstract_text> ..
  37. Methionine Adenosyltransferase as a Therapeutic Target for Liver Fibrosis
    Komal Ramani; Fiscal Year: 2013
    ..My long term plan is to establish myself as an independent Investigator in the field of human liver fibrosis and cirrhosis. ..
  38. A PDGFR inhibitor for the treatment of pulmonary arterial hypertension
    Lawrence S Zisman; Fiscal Year: 2010
    ..The purpose of this proposal is to develop a novel highly selective platelet derived growth factor receptor (PDGFR) inhibitor for PAH that will be delivered by inhalation...
  39. Gregory J Gores; Fiscal Year: 2016
    ..We have also generated striking preliminary data demonstrating that myofibroblast- derived platelet derived growth factor-BB (PDGF-BB) augments hedgehog signaling in CCA cells...
  40. Role of Acetaldehyde on PDGF-BB-induced HSC Migration and Proliferation.
    Raj M Lakshman; Fiscal Year: 2011
    ..Our long term goal is to unravel key molecular events triggered by acetaldehyde that could lead to therapeutic intervention and thus, to prevention and/or amelioration of alcohol-induced liver fibrosis and cirrhosis. ..
  41. Harish Vasudevan; Fiscal Year: 2015
    ..The cranial neural crest, an essential contributor to the facial skeleton, requires platelet derived growth factor (PDGF) signaling...
  42. Methionine Adenosyltransferase as a Therapeutic Target for Liver Fibrosis
    Komal Ramani; Fiscal Year: 2010
    ....
  43. Amorphous computation with transcription logic gates
    Andrew D Ellington; Fiscal Year: 2013
    ..The results of these inquiries should help understand development, including how development sometimes goes awry during disease formation, and may assist with building nanoscale devices for therapy and diagnostics. ..
  44. Characterizing the mechanisms of PDGFRalpha regulation in upper lip development
    Fenglei He; Fiscal Year: 2013
    ..Mutations of Platelet Derived Growth Factor Receptor [unreadable] (PDGFR[unreadable]) signaling have been tightly linked to cleft lip/palate in ..
  45. Sang Don Koh; Fiscal Year: 2016
    ..This information will open up important novel areas of investigation in urodynamics physiology and expand new venue of treatment of bladder over activity. ..
  46. Platlelet Derive Growth Factor Receptor-Alpha (PDGFRa) in Liver Development
    Prince K Awuah; Fiscal Year: 2012
    ..We have identified peak expression of Platelet derived growth factor receptor-a (PDGFRa) during early stages of liver development at embryonic days 11 (E11) to E14...
  47. Vascular abnormalities in patients receiving a dialysis access.
    Michael Allon; Fiscal Year: 2013
    ....
  48. Daniel A Lawrence; Fiscal Year: 2016
    ..In recent studies we demonstrated that tPA within the brain activates latent platelet derived growth factor CC (PDGF- CC), which in turn increases BBB dysfunction in stroke, and that blocking this pathway ..
  49. Wei Zhang; Fiscal Year: 2014
    ..This in-depth understanding will provide insight in the development of targeted therapeutics for high-grade gliomas. ..
  50. Johann K Eberhart; Fiscal Year: 2016
    ....
  51. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..This proposal will also determine whether PDGF inhibition could provide important adjuvant therapy for the treatment of severe asthmatics by limiting structural changes that result from activity of this pathway. ..
  52. ALISA ANNE MUELLER; Fiscal Year: 2015
    ..Our investigation will both allow for the production of new experimental tools to study this population and lend insight into therapeutic strategies to prevent age-related fibrosis. ..
  53. Therapeutic Targets in Alveolar Rhabdomyosarcoma
    Charles Keller; Fiscal Year: 2012
    ..This study of platelet-derived growth factors in cancer progression establishes proof-of- principal for a systematic, rational genetic approach to molecular therapeutics in childhood alveolar rhabdomyosarcomas and other tumors. ..
  54. Shilpa J Buch; Fiscal Year: 2016
    ....
  55. Ryan M Schweller; Fiscal Year: 2015
    ....
  56. Biomimetic Scaffold Delivering Osteogenic Molecules for Alveolar Bone Engineering
    Min Lee; Fiscal Year: 2013
    ..The results from this proposal will be critical towards clinical translation of Nell-1 mediated therapeutics to augment alveolar bone regeneration while minimizing potential adverse effects of current osteoinductive therapeutics. ..
  57. Luguang Luo; Fiscal Year: 2015
    ..Our long term goal is to identify the mechanism(s) by which encapsulated islets plus BM cells sustain islet function in vivo and prevent islet rejection in the absence of generalized immunosuppression for translation to the clinic. ..
  58. Gene/environment interactions underlying Fetal Alcohol Spectrum Disorder.
    Neil McCarthy; Fiscal Year: 2012
    ..By screening available zebrafish craniofacial mutants, platelet derived growth factor receptor a (pdgfra) and fibroblast growth factor 8a (fgf82) were identified as ethanol sensitive loci...
  59. Tohru Fukai; Fiscal Year: 2016
    ..These studies will provide new insight into copper transporters as potential therapeutic targets for cardiovascular diseases such as atherosclerosis. ..
  60. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Wei Zhang; Fiscal Year: 2009
    ..abstract_text> ..
  61. Lawrence S Zisman; Fiscal Year: 2016
    ..is to develop a new treatment for pulmonary arterial hypertension (PAH) consisting of the inhaled platelet derived growth factor receptor (PDGFR) inhibitor PK10453...
  62. Genetic Modulation of Vascular Smooth Muscle Phenotype and Intimal Hyperplasia
    Sara J Runge; Fiscal Year: 2012
    ....
  63. Human Choriogonadotropin Signaling in Cell Proliferation
    MICHAEL HUDECKI; Fiscal Year: 2003
    ..abstract_text> ..
  64. Growth factor delivery patch for wound healing
    Fen Zhang; Fiscal Year: 2005
    ..Despite the recent introduction of advanced therapeutic products such as recombinant platelet derived growth factor, and artificial skin products, the healing of chronic wounds is extremely slow and often times ..
  65. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..These studies will identify important signaling mechanisms involved in glomerular pathology and help to establish effective therapeutic modalities for treatment of proliferative forms of GN. ..
  66. SIGNAL TRANSDUCTION BY TEL/TYROSINE KINASE FUSIONS
    David Sternberg; Fiscal Year: 2003
    ..The candidate's career goals and research career development plan are detailed in Section II of this proposal. ..
  67. Analysis of the Novel Kinase ROR2: A New Molecular Target in Renal Cell Carcinoma
    Tricia M Wright; Fiscal Year: 2010
    ..The long term goal of this study is not only to analyze the importance of ROR2 in RCC but also to use the gained knowledge of ROR2 function in the hopes of finding inhibitors that can be used clinically for treating RCC. ..
  68. Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic
    Paul Hamilton; Fiscal Year: 2006
    ..b>Platelet Derived Growth Factor (PDGF) is a potent chemotactic, mitogen, and differentiation factor that promotes soft tissue ..
  69. MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    Daniel Donoghue; Fiscal Year: 2001
    ..These experiments may thus be expected to increase our understanding of the molecular mechanisms employed by the HPVs to deregulate the control of cellular proliferation. ..
  70. Acquired Resistance to VEGF blockade in Wilms tumor
    Jessica Kandel; Fiscal Year: 2007
    ..The resulting preclinical data may provide a rational basis for use of anti-angiogenic therapies in Wilms tumor, and assist in circumventing their limitations. ..