neurotrophin 3

Summary

Summary: A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.

Top Publications

  1. ncbi Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
    F Gomez-Pinilla
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
    Eur J Neurosci 13:1078-84. 2001
  2. ncbi Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats
    Liudmila N Novikova
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, SE 901 87 Umea, Sweden
    J Comp Neurol 452:255-63. 2002
  3. ncbi Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury
    Kook In Park
    Department of Pediatrics, and the Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea
    Exp Neurol 199:179-90. 2006
  4. ncbi Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
    I Farinas
    Department of Physiology, University of California School of Medicine, San Francisco 94143 0724
    Nature 369:658-61. 1994
  5. ncbi NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
    N Francis
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    Dev Biol 210:411-27. 1999
  6. pmc Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
    L Tessarollo
    Neural Development Group, ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 94:14776-81. 1997
  7. pmc Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons
    Jacob Tauris
    Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Eur J Neurosci 33:622-31. 2011
  8. pmc Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation
    K M Albers
    Department of Pathology, University of Kentucky Medical Center, Lexington 40536, USA
    J Cell Biol 134:487-97. 1996
  9. ncbi Neurotrophins and trk-receptors in adult rat spinal motoneurons: differences related to cell size but not to 'slow/fast' specialization
    S Copray
    Department of Medical Physiology, University of Groningen, The Netherlands
    Neurosci Lett 289:217-20. 2000
  10. ncbi The effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cells
    Xiaoguang Li
    Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069, China
    Biomaterials 30:4978-85. 2009

Detail Information

Publications330 found, 100 shown here

  1. ncbi Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
    F Gomez-Pinilla
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
    Eur J Neurosci 13:1078-84. 2001
    ..These results show that neuromuscular activity has specific effects on the BDNF and NT-3 systems, and that repetitive exercise affects the magnitude and stability of these responses...
  2. ncbi Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats
    Liudmila N Novikova
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, SE 901 87 Umea, Sweden
    J Comp Neurol 452:255-63. 2002
    ....
  3. ncbi Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury
    Kook In Park
    Department of Pediatrics, and the Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea
    Exp Neurol 199:179-90. 2006
    ....
  4. ncbi Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
    I Farinas
    Department of Physiology, University of California School of Medicine, San Francisco 94143 0724
    Nature 369:658-61. 1994
    ..16). In particular, neurotrophin-3 is essential for survival of sympathetic and sensory neurons that later become dependent on nerve growth factor or brain-derived neurotrophic factor...
  5. ncbi NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
    N Francis
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    Dev Biol 210:411-27. 1999
    ..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor...
  6. pmc Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
    L Tessarollo
    Neural Development Group, ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 94:14776-81. 1997
    ..The similarities in cardiac defects observed in the trkC and NT-3 null mutant mice indicate that the trkC receptor mediates most NT-3 effects on the cardiac neural crest...
  7. pmc Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons
    Jacob Tauris
    Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Eur J Neurosci 33:622-31. 2011
    ..However, our results suggest that proNT3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex...
  8. pmc Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation
    K M Albers
    Department of Pathology, University of Kentucky Medical Center, Lexington 40536, USA
    J Cell Biol 134:487-97. 1996
    ..These results indicate that in vivo overexpression of NT-3 by the epidermis enhances the number of sensory and sympathetic neurons and the development of selected sensory endings of the skin...
  9. ncbi Neurotrophins and trk-receptors in adult rat spinal motoneurons: differences related to cell size but not to 'slow/fast' specialization
    S Copray
    Department of Medical Physiology, University of Groningen, The Netherlands
    Neurosci Lett 289:217-20. 2000
    ..slow' categories of motoneurons...
  10. ncbi The effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cells
    Xiaoguang Li
    Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069, China
    Biomaterials 30:4978-85. 2009
    ..These results may provide an experimental basis for the maximum replacement of dead neurons by neural stem cell transplant after spinal cord injury (SCI)...
  11. pmc Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro
    L N Pettingill
    The Bionic Ear Institute, 384 Albert Street, East Melbourne, Australia 3002
    Neuroscience 152:821-8. 2008
    ..which were genetically modified to over-express the neurotrophins brain-derived neurotrophic factor (BDNF) or neurotrophin 3 (Ntf3, formerly NT-3) could support SGN survival in an in vitro model of deafness...
  12. pmc Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3
    James M Massey
    School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 209:426-45. 2008
    ..These results demonstrate both an additional challenge and potential treatment strategy for successful functional pathway reconstruction after SCI...
  13. ncbi Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats
    Vanessa S Boyce
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 98:1988-96. 2007
    ..Finally, the results show that transplants beneficial in rodents are applicable to larger mammals...
  14. ncbi Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus
    M Torasdotter
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden
    Behav Brain Res 93:83-90. 1998
    ....
  15. pmc Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro
    Qiong Wang
    Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 31:7938-49. 2011
    ....
  16. ncbi Functional regeneration of sensory axons into the adult spinal cord
    M S Ramer
    Neuroscience Research Centre, Guy s, King s and St Thomas School of Biomedical Sciences, London, UK
    Nature 403:312-6. 2000
    ..Neurotrophic factor treatment may thus serve as a viable treatment in promoting recovery from root avulsion injuries. I..
  17. ncbi Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury
    J S Guo
    Division of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou 510080, P R China
    Spinal Cord 45:15-24. 2007
    ..An animal model of transected spinal cord injury (SCI) was used to test the hypothesis that cografted neural stem cells (NSCs) and NT-3-SCs promote morphologic and functional recoveries of injured spinal cord...
  18. ncbi Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5
    X Liu
    Department of Pathology and Molecular Medicine, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    Dev Dyn 218:94-101. 2000
    ..Our results suggest that neurotrophins are essential for the survival of most peripheral sensory neurons and affect the survival of a small portion of motor neurons during embryogenesis...
  19. ncbi Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease
    Susanne A Wolf
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Charite University Medicine, Berlin, Germany
    Biol Psychiatry 60:1314-23. 2006
    ..Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD)...
  20. ncbi Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons
    A Chalazonitis
    Department of Anatomy and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 21:5620-36. 2001
    ..A neuropoietic cytokine (CNTF) interacted with NT-3 in vitro, and if applied sequentially, compensated for NT-3 withdrawal. These observations indicate that NT-3 is required for the normal development of the ENS...
  21. ncbi Nerve growth factor and asthma
    Caroline Olgart Hoglund
    Institut National de la Santé et de la Recherche Médicale Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, B P 24, 67 401 Illkirch Cedex, France
    Pulm Pharmacol Ther 15:51-60. 2002
  22. ncbi Neurotrophin 3 promotes purification and proliferation of olfactory ensheathing cells from human nose
    John I Bianco
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Nathan, Queensland 4111, Australia
    Glia 45:111-23. 2004
    ..on three neurotrophic factors, namely nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT3)...
  23. ncbi Dependence of developing group Ia afferents on neurotrophin-3
    J Kucera
    Department of Neurology, Boston University Medical Center, Massachusetts 02118 2394, USA
    J Comp Neurol 363:307-20. 1995
    ..Thus, developing Ia neurons may be dependent on NT-3 intrinsic to the DRGs before they reach a stage of potential dependence on NT-3 retrogradely derived from skeletal muscles or spinal motor neurons...
  24. pmc Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo
    Anna Stenqvist
    Unit of Molecular Neurobiology, MBB, Karolinska Institutet, Stockholm, Sweden
    EMBO Rep 6:973-8. 2005
    ..However, several in vitro and in vivo studies of null mutant mice have suggested that neurotrophin 3 (NT 3) also signals through the non-preferred TrkB receptor...
  25. pmc Enhancing proprioceptive input to motoneurons differentially affects expression of neurotrophin 3 and brain-derived neurotrophic factor in rat hoffmann-reflex circuitry
    Olga Gajewska-Wozniak
    Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland
    PLoS ONE 8:e65937. 2013
    The importance of neurotrophin 3 (NT-3) for motor control prompted us to ask the question whether direct electrical stimulation of low-threshold muscle afferents, strengthening the proprioceptive signaling, could effectively increase the ..
  26. pmc A role for NT-3 in the hyperinnervation of neonatally wounded skin
    Simon Beggs
    Programme in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
    Pain 153:2133-9. 2012
    ..We conclude that upregulation of NT-3 in neonatally wounded skin is a critical factor mediating the sensory nerve sprouting that underlies hypersensitivity and pain following skin injury...
  27. ncbi Glutamate stimulates neurotrophin expression in cultured Müller cells
    Sara Taylor
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res Mol Brain Res 111:189-97. 2003
    ..Moreover, the increased secretion of neurotrophic factors and upregulation of L-glutamate/L-aspartate transporter (GLAST) expression in Müller cells may protect retinal neurons from glutamate toxicity...
  28. ncbi The neurotrophin receptor p75NTR as a positive modulator of myelination
    Jose M Cosgaya
    Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Building, Stanford, CA 94305, USA
    Science 298:1245-8. 2002
    ..Thus p75NTR and TrkC receptors have opposite effects on myelination...
  29. ncbi Complementary roles of BDNF and NT-3 in vestibular and auditory development
    P Ernfors
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Neuron 14:1153-64. 1995
    ..These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems...
  30. ncbi Neuroprotection of neurotrophin-3 against focal cerebral ischemia/reperfusion injury is regulated by hypoxia-responsive element in rats
    J Zhang
    Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, PR China
    Neuroscience 222:1-9. 2012
    ..To avoid unexpected side effects, 5HRE-controlled gene expression might be a useful tool for gene therapy of ischemic disorders in the central nervous system...
  31. ncbi NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord
    E J Bradbury
    Neuroscience Research Centre, Guys, Kings and St Thomas School of Biomedical Sciences, Division of Physiology, Lambeth Palace Road, London E1 4NS, UK
    Eur J Neurosci 11:3873-83. 1999
    ....
  32. ncbi Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Doktorsringen 12A, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurosci 17:8667-75. 1997
    ....
  33. ncbi Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions
    M Torasdotter
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden
    Neurosci Lett 218:107-10. 1996
    ..These results indicate a possible role for NT-3 in synaptic plasticity...
  34. ncbi The effect of the dosage of NT-3/chitosan carriers on the proliferation and differentiation of neural stem cells
    Zhaoyang Yang
    The School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
    Biomaterials 31:4846-54. 2010
    ....
  35. pmc The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection
    Andrew K Wise
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, Victoria 3002, Australia
    Hear Res 278:69-76. 2011
    ..Clinically, there remains a window of opportunity in which NT gene therapy can provide ongoing trophic support for SGNs...
  36. pmc Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain
    Neena K Sharma
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Mail Stop 2002, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Phys Ther 90:714-25. 2010
    ..However, the molecular basis for the positive actions of exercise remains poorly understood. Recent studies suggest that neurotrophin-3 (NT-3) may act in an analgesic fashion in various pain states...
  37. pmc Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury
    Hannah M Tuinstra
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 3120, USA
    Biomaterials 33:1618-26. 2012
    ..Combining gene delivery with biomaterials to provide physical guidance and create a permissive environment can provide a platform to enhance axonal growth and promote regeneration...
  38. ncbi trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
    F Lamballe
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Cell 66:967-79. 1991
    ..These results indicate that gp145trkC may play an important role in mediating the neurotrophic effects of NT-3...
  39. ncbi Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy
    Lu Ting Kuo
    Department of Molecular Neuroscience, Division of Neuropathology, Institute of Neurology, London WC1N 3BG, UK
    J Comp Neurol 482:320-32. 2005
    ..Our results suggest that the presence of nestin in DRG neurons after nerve injury is due to recent differentiation and that exogenous NT-3 may prevent neuron loss by stimulating this process, rather than preventing neuron death...
  40. pmc Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neurons
    Mitchell Kundel
    Department of Cell Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    J Neurosci 29:13630-9. 2009
    ..Together, these results suggest that CPEB1 regulates beta-catenin synthesis in neurons and may contribute to neuronal morphogenesis...
  41. pmc Immune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injury
    Qin Chen
    Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Neurol 209:497-509. 2008
    ..These observations demonstrate that processes associated with immune-mediated wound healing play a role in NT-3-induced neuroplasticity after injury...
  42. ncbi Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord
    M Oudega
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, PO Box 016960, R 48, Miami, FL 33136, USA
    Brain Res 818:431-8. 1999
    ..These findings suggest that injured ascending sensory axons are responsive to all three neurotrophins and confirm our previous findings that neurotrophic factors can promote regeneration in the adult central nervous system...
  43. ncbi p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
    A M Davies
    School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
    Neuron 11:565-74. 1993
    ..These findings indicate that p75 enhances the sensitivity of NGF-dependent cutaneous sensory neurons to NGF and may explain, at least in part, the cutaneous sensory abnormalities of mice homozygous for the p75 mutation...
  44. ncbi Complementary actions of BDNF and neurotrophin-3 on the firing patterns and synaptic composition of motoneurons
    María A Davis-López de Carrizosa
    Departamento de Fisiologia y Zoologia, Facultad de Biologia, Universidad de Sevilla, Sevilla, Spain
    J Neurosci 29:575-87. 2009
    ..These trophic actions could be responsible, in part, for synaptic rearrangements that alter circuit stability and synaptic balance during plastic events of the brain...
  45. ncbi Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice
    D J Liebl
    Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
    J Neurosci 17:9113-21. 1997
    ..We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes...
  46. ncbi Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses
    N Durany
    Laboratory for Neurochemistry, University of Wurzburg, Wurzburg, Germany
    Schizophr Res 52:79-86. 2001
    ....
  47. ncbi Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation
    M S Airaksinen
    Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg Martinsried, Republic of Germany
    Neuron 16:287-95. 1996
    ..Thus, NT-3 is essential for the maintenance of specific cutaneous afferents known to subserve fine tactile discrimination in humans...
  48. ncbi NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients
    Z Sahenk
    Department of Neurology, Ohio State University, Columbus, OH, USA
    Neurology 65:681-9. 2005
    ..Neurotrophin-3 (NT-3), an important component of the Schwann cell (SC) autocrine survival loop, could correct these deficiencies...
  49. pmc Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats
    Jeffrey C Petruska
    Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, NY 11794, USA
    Eur J Neurosci 32:997-1005. 2010
    ..This approach to neurotrophin delivery could be useful in modifying spinal function after injury...
  50. ncbi Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro
    I Gavazzi
    Department of Developmental Neurobiology, King s College London, Guy s Campus, UK
    Eur J Neurosci 11:3405-14. 1999
    ..BDNF exerted an inhibitory effect on growth, and both BDNF and NT-3 could partially block some of the growth-promoting effects of NGF on specific neuronal subpopulations...
  51. ncbi Localization of TrkC to Schwann cells and effects of neurotrophin-3 signaling at neuromuscular synapses
    Darren M Hess
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6074, USA
    J Comp Neurol 501:465-82. 2007
    ..Together, these results demonstrate that NT3 expression is developmentally regulated in skeletal muscle and may modulate the number of Schwann cells at neuromuscular synapses...
  52. ncbi Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function
    B Blits
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroscience 118:271-81. 2003
    ..Our results suggest that AAV vector-mediated overexpression of BDNF and NT-3 in the cord caudal to a Schwann cell bridge modified the local lumbar axonal circuitry, which was beneficial for locomotor function...
  53. pmc Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo
    I Farinas
    Department of Physiology, University of California, San Francisco 94143, USA
    Neuron 21:325-34. 1998
    ..Results also indicate that survival of cells expressing both receptors can be maintained by activation of either one alone. NT-3 can thus activate more than one Trk receptor in vivo, which when coexpressed are functionally redundant...
  54. pmc Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurosci 17:6213-25. 1997
    Essential functions of neurotrophin 3 (NT-3) in regulating afferent and efferent innervation of the cochlea have been characterized by comparison of normal and NT-3 mutant mice...
  55. ncbi Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS
    V Lessmann
    Department of Molecular Neurobiochemistry, Ruhr Universitat Bochum, Germany
    Gen Pharmacol 31:667-74. 1998
    ..Thus, neurotrophins might operate as locally released feedback modulators of synaptic transmission, and this could be a cellular correlate for certain aspects of information processing in the mammalian brain...
  56. ncbi An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury
    J Piantino
    Department of Neurosurgery, Children s Hospital, Boston, MA 02115, USA
    Exp Neurol 201:359-67. 2006
    ..These studies demonstrate the effectiveness of hydrogel technology as a clinically feasible delivery system to promote regeneration and enhance functional outcome after spinal cord injury...
  57. ncbi Co-transplantation of neural stem cells and NT-3-overexpressing Schwann cells in transected spinal cord
    Xuebao Zhang
    Department of Histology and Embryology, Institute of Spinal Cord Injury, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    J Neurotrauma 24:1863-77. 2007
    ..However, this pre-differentiation of NSCs in vitro only mildly improved neuronal differentiation of NSCs in vivo...
  58. ncbi Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord
    Andres Hurtado
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, P O Box 016960, R 48, Miami, FL 33136, USA
    Biomaterials 27:430-42. 2006
    ..For the development of SC-seeded macroporous scaffolds that effectively promote axonal regeneration in the injured spinal cord, the survival and/or total number of SCs in the scaffold needs to be improved...
  59. pmc Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury
    Philip J Johnson
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Biotechnol Bioeng 104:1207-14. 2009
    ..These results demonstrate that the controlled release of NT-3 from fibrin scaffolds can enhance neural fiber sprouting even when treatment is delayed 2 weeks following injury...
  60. ncbi Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion
    Helge Rask-Andersen
    Department of Otosurgery, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Hear Res 203:180-91. 2005
    ..Transplantation of progenitor cells together with established means to induce neural differentiation and fiber growth may facilitate strategies for better repair and treatment of auditory neuronal damage...
  61. ncbi Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord
    Zhe Ying
    Department of Physiological Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
    Brain Res 987:93-9. 2003
    ....
  62. pmc SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in rats
    Tracy M Clement
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA
    Biol Reprod 85:277-84. 2011
    b>Neurotrophin 3 (Ntf3) is expressed in Sertoli cells and acts as a chemo-attractant for cell migration from the mesonephros into the developing testis, a process critical to the early morphological events of testis cord formation...
  63. ncbi Hypothermia-induced neurite outgrowth is mediated by tumor necrosis factor-alpha
    Katharina R L Schmitt
    Clinic for Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum, Berlin, Germany
    Brain Pathol 20:771-9. 2010
    ..These data suggest that hypothermia not only exerts protective effects in the CNS but may also support neurite outgrowth as a potential mechanism of regeneration...
  64. ncbi Local and target-derived actions of neurotrophins during peripheral nervous system development
    P Ernfors
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Cell Mol Life Sci 58:1036-44. 2001
    ....
  65. ncbi Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord
    Qin Chen
    Center for Cell and Gene Therapy and Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurotrauma 23:1254-60. 2006
    ..Since the processes of WD would have resolved within 4 months after injury, these data demonstrate that products of WD are a potential source of the co-inducing signals that support neuroplasticity in the presence of NT-3...
  66. ncbi Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3
    Andrew K Wise
    The Bionic Ear Institute, East Melbourne 3002, Australia
    J Comp Neurol 487:147-65. 2005
    ..These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf...
  67. ncbi Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells
    H E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
    Biotech Histochem 87:506-11. 2012
    ..IL-1ß exposure in three-dimensional culture significantly increased expression of neurotrophin 3, brain-derived neurotrophic factor, and neuropilin 2 compared to controls...
  68. ncbi Reduction of NT-3 or TrkC results in fewer putative vagal mechanoreceptors in the mouse esophagus
    Marion Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Auton Neurosci 108:22-31. 2003
    ..This concurs with their proposed function as vagal mechanosensors crucial for reflex peristalsis...
  69. ncbi Tool-use learning selectively induces expression of brain-derived neurotrophic factor, its receptor trkB, and neurotrophin 3 in the intraparietal multisensorycortex of monkeys
    Hidetoshi Ishibashi
    Section of Cognitive Neurobiology, Department of Maxillofacial Biology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8549, Tokyo, Japan
    Brain Res Cogn Brain Res 14:3-9. 2002
    ..These results suggest that these factors are involved in the reorganization of the somatosensory and visual signals in the anterior bank of the intraparietal sulcus when monkeys are learning the use of the tool...
  70. pmc A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3
    Tan Li
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Toxicol Sci 134:111-24. 2013
    ..6-OH-PBDE-47 also inhibited the proneuronal differentiation effect of neurotrophin 3 (NT3) and NT3 activation of ERK5...
  71. ncbi Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice
    Asaka Saito
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
    Environ Toxicol 26:224-32. 2011
    ..These findings demonstrate that FA has more potent irritancy against skin than toluene or xylene and suggest that the Th2 response, neurotrophins and TRPV-1 play important roles in FA-induced skin inflammation...
  72. ncbi NT-3 expression in spared DRG and the associated spinal laminae as well as its anterograde transport in sensory neurons following removal of adjacent DRG in cats
    Ting Hua Wang
    Institute of Neurological Disease, West China Hospital, Sichuan University, Chendu 610041, China
    Neurochem Res 33:1-7. 2008
    ..The above results indicate that DRG may be a source of neurotrophic factors such as NT-3 to the spinal cord, and may contribute to plasticity in the spinal cord after injury...
  73. ncbi Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils
    O Noga
    Allergy and Asthma Clinic, Charite, Campus Virchow, Humboldt University, Berlin, Germany
    Clin Exp Allergy 32:1348-54. 2002
    ..Recent studies have shown that nerve growth factor (NGF) can act on several immune cells as well as residential cells. But little is known about their role in modulating eosinophil function via activation of high-affinity receptors...
  74. ncbi Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
    Fanie Barnabe-Heider
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Neurosci 23:5149-60. 2003
    ..Thus, neurotrophins made by cortical progenitor cells themselves signal through the TrkB and TrkC receptors to mediate cortical progenitor cell survival and neurogenesis via two distinct downstream signaling pathways...
  75. ncbi Pro-inflammatory cytokines upregulate the skin immunoreactivity for NGF, NT-3, NT-4 and their receptor, p75NTR in vivo: a preliminary report
    Holger Bläsing
    Department of Dermatology, University Hospital Eppendorf, Hamburg University, Martinistrasse 52, 20246, Hamburg, Germany
    Arch Dermatol Res 296:580-4. 2005
    ..This raises the question to which extent several of the recognized cutaneous effects of IFNgamma, IL-1beta and TNF-alpha are mediated indirectly via modulating the expression of selected NTs and/or NTRs...
  76. ncbi Expression and function of neurotrophins and their receptors in cultured human keratinocytes
    A Marconi
    Institute of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    J Invest Dermatol 121:1515-21. 2003
    ..Finally, neurotrophins other than nerve growth factor fail to protect human keratinocytes from ultraviolet B-induced apoptosis. This work delineates a functional neurotrophin network, which may contribute to epidermal homeostasis...
  77. pmc Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway
    Junji Yamauchi
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
    Proc Natl Acad Sci U S A 100:14421-6. 2003
    ..Here we show that migration of Schwann cells, isolated from sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-derived neurotrophic factor...
  78. ncbi Postnatal regulation of limb proprioception by muscle-derived neurotrophin-3
    M D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Comp Neurol 432:244-58. 2001
    ..However, our results also show that NT-3 may be therapeutic for proprioceptive axons immediately after nerve injury by delaying axon degeneration...
  79. ncbi Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
    Hear Res 198:25-35. 2004
    ..NT-3 microspheres remained in the cochlea for at least 28 days, suggesting a low clearance rate within cochlear tissues...
  80. ncbi Secretion of intrinsic cues controls repulsion of nociceptive neurons
    Sonia Montazeri
    Neuroscience Research Center, Charite, Central Campus, Department of Molecular Neurobiology, Hufelandweg 14, 10177 Berlin, Germany
    Mol Cell Neurosci 24:595-602. 2003
    ..Our data provide evidence that the segmented pattern of skin nociceptive sensory maps is supported by unknown intrinsic cues released from the sensory axons themselves...
  81. ncbi Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons
    R O'CONNOR
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143, USA
    Neuron 24:165-78. 1999
    ....
  82. ncbi Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors
    Sabrina L McIlwrath
    Department of Neurobiology, School of Medicine, University of Pittsburgh, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Eur J Neurosci 26:1801-12. 2007
    ..These results indicate that cutaneous NT3 overexpression alters the response properties of specific cutaneous sensory neurons, and that these changes may be due to the modulation of putative mechanosensitive ion channels...
  83. ncbi Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation
    Noriyoshi Usui
    Department of Physiological Sciences, School of Life Science, The GraduateUniversity for Advanced Studies SOKENDAI, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Development 139:1125-32. 2012
    ..5. To understand the motoneuron-derived factor that regulates sensory neuron development, we focused on neurotrophin 3 (Ntf3; NT-3), because Ntf3 and its receptors (Trk) are strongly expressed in motoneurons and sensory neurons, ..
  84. pmc Neurotrophin-3 promotes the differentiation of muscle spindle afferents in the absence of peripheral targets
    R A Oakley
    Department of Neurobiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 17:4262-74. 1997
    ..Together, our results indicate that NT3 signaling is both necessary and sufficient for the development of the proprioceptive phenotype, even in the absence of other signals from limb muscle...
  85. pmc Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract
    Edward A Fox
    Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
    Cell Tissue Res 340:267-86. 2010
    ....
  86. ncbi Decreased NT-3 plasma levels and platelet serotonin content in patients with hypochondriasis
    Natascia Brondino
    Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
    J Psychosom Res 65:435-9. 2008
    ..Although NTs have been associated to a variety of mental disorders, the potential role of NT alterations in hypochondriasis (HC) has never been investigated...
  87. ncbi Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI
    Jenny Fortun
    The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 26:941-53. 2009
    ..Muscle injections of AAV5-neurotrophin 3 (NT3) resulted in a significant increase in the levels of NT3 in the cervical enlargement, compared to those ..
  88. pmc Prenatal exposure to elevated NT3 disrupts synaptic selectivity in the spinal cord
    Zhi Wang
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurosci 27:3686-94. 2007
    ..These results indicate that prenatal exposure to elevated levels of NT3 disrupts the normal mechanisms responsible for synaptic selectivity in the stretch reflex circuit...
  89. ncbi Peripheral projections of rat primary sensory neurons immunoreactive for neurotrophin 3
    X F Zhou
    Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia
    J Comp Neurol 363:69-77. 1995
    ..We have recently reported that a subpopulation of large diameter sensory neurons of the rat contain neurotrophin 3-like immunoreactivity (NT3-ir)...
  90. ncbi Development and specification of muscle sensory neurons
    H H Chen
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Bioscience Tower W1452, 3500 Terrace Street, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Neurobiol 9:405-9. 1999
    ..The explosion of new information on neurotrophins, however, has revealed that neurotrophin 3 (NT3) is critically involved in several aspects of this development, including the initial differentiation, ..
  91. ncbi Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system
    T Ringstedt
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Development 124:2603-13. 1997
    ..These findings suggest novel roles for NT3 in differentiation of proprioceptive neurons, target invasion and formation of Ia projections which are independent from its effects on neuronal survival...
  92. pmc Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors
    C S von Bartheld
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 16:2995-3008. 1996
    ....
  93. ncbi Herbal formula SYJN increases neurotrophin-3 and nerve growth factor expression in brain regions of rats exposed to chronic unpredictable stress
    Qing Qiu Mao
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    J Ethnopharmacol 131:182-6. 2010
    ..The present study aimed to investigate whether neurotrophin-3 (NT-3) and nerve growth factor (NGF) are involved in the antidepressant-like action of SYJN by using the same depressive model in rats...
  94. ncbi Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury
    P Lu
    Department of Neurosciences, University of California at San Diego, La Jolla 92093 0626, USA
    Exp Neurol 181:115-29. 2003
    ..Thus, stem cells can promote host neural repair in part by secreting growth factors, and their regeneration-promoting activities can be modified by gene delivery...
  95. ncbi Direct and indirect effects of neuropeptide Y and neurotrophin 3 on myelination in the neonatal brains
    Ryuju Hashimoto
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Brain Res 1373:55-66. 2011
    ..In cultured oligodendroglioma-derived B12 cells, NPY didn't influence the MBP-mRNA expression, while neurotrophin 3 (NT3) increased MBP mRNA via receptor-type tyrosine kinase type C (Trk C)...
  96. ncbi Expression of neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral follicles
    Galia Oron
    Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Fertil Steril 95:2056-62. 2011
    To investigate the expression of neurotrophin 3 (NT3) and its receptor tropomyosin-related kinase C (TrkC) in human preantral follicles. Neurotrophins appear to play important roles in preantral follicles...
  97. ncbi Differential regulation of axon outgrowth and reinnervation by neurotrophin-3 and neurotrophin-4 in the hippocampal formation
    Daniel Hechler
    Institute for Cell Biology and Neurobiology, Center for Anatomy, Charite, Universitatsmedizin, Berlin, Germany
    Exp Brain Res 205:215-21. 2010
    ..These results suggest that endogenous and exogenous NT-3 and NT-4 differentially influence neurite growth depending on the presence or absence of target tissue...
  98. pmc Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons
    Rungtip Soiampornkul
    Neuro Behavioral Biology Center, Institute of Science and Technology for Development, Mahidol University, Salaya Campus Nakorn Pathom, Thailand
    Brain Res 1188:189-97. 2008
    ....
  99. ncbi Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons
    Victor L Arvanian
    Dept of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Bldg Rm 550, Stony Brook, NY 11794 5230, USA
    J Neurophysiol 92:2394-404. 2004
    ..This approach might be useful for enhancing the function of fibers surviving in the damaged spinal cord...
  100. ncbi Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat
    Victor L Arvanian
    Department of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Building, Stony Brook, NY 11794 5230, USA
    Exp Neurol 197:347-52. 2006
    ....
  101. ncbi Combined treatment with neurotrophin-3 and LSD facilitates behavioral recovery from double-hemisection spinal injury in neonatal rats
    Victor L Arvanian
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794 5230, USA
    J Neurotrauma 23:66-74. 2006
    ..Rearing frequency reached sham control levels by P40. Our results suggest this combination treatment may be a promising new strategy for facilitating recovery from moderate spinal cord injury...

Research Grants65

  1. Analysis of Kinesins Mediating Neurotrophin Transport
    Rafal Butowt; Fiscal Year: 2006
    ..abstract_text> ..
  2. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  3. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..multiple neurotrophin ligands, including nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin 3. The hypothesis to be tested in the proposed studies is that NGFR controls the proliferation, survival, and ..
  4. DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATES
    Ned H Kalin; Fiscal Year: 2013
    ..Relevant to this, we have amassed evidence that activity of the neurotrophin 3 (NTF3)/neurotrophic tyrosine kinase receptor type 3 (NTRK3) neuroplasticity system in the CeA is inversely ..
  5. Cellular therapy for the inner ear
    Albert S Edge; Fiscal Year: 2013
    ..abstract_text> ..
  6. Bioengineered scaffolds for peripheral nerve repair
    Ravi V Bellamkonda; Fiscal Year: 2010
    ..include biochemical cues, such as growth stimulatory extracellular matrix (laminin-1) and trophic protein (Neurotrophin 3, NT-3)...
  7. Intracellular Target of Sphingosine-1-Phosphate
    GRAHAM M STRUB; Fiscal Year: 2010
    ..Deciphering the mechanism of action of this sphingolipid metabolite could provide clues for the prevention and treatment of devastating human neurodegenerative diseases. ..
  8. NT-3 gene therapy to improve peripheral nerve function induced by genetic defect
    Zarife Sahenk; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The premise for this proposal is that AAV1 mediated gene delivery of neurotrophin 3 (NT-3) will provide clinical improvement in the most common inherited neuropathy, Charcot-Marie-Tooth neuropathy ..
  9. Mechanism of Neurotrophin Latency Response in a HSV1 Vestibular Neuritis Model
    PAMELA CAROL ROEHM; Fiscal Year: 2013
    ....
  10. Neurotrophin Specificity and Function in the Taste System
    Christopher Nosrat; Fiscal Year: 2009
    ..We have shown that two members of the neurotrophin family, Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) play important roles in the innervation of the developing tongue...
  11. miR-200c Mediates Suppression of Anoikis Resistance by Targeting an Autocrine Sig
    ERIN NICOLE HOWE; Fiscal Year: 2012
    ..Furthermore, neurotrophin 3 (NTF3), a ligand for TrkB has 2 predicted miR-200c binding sites in the 3'UTR...
  12. Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    Xiaorong Liu; Fiscal Year: 2011
    ..the investigators will focus on the roles of two neurotrophins, Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3)...
  13. A Rational Approach to Stimulating Peripheral Nerve Regeneration Across Criticall
    Ravi V Bellamkonda; Fiscal Year: 2013
    ..abstract_text> ..
  14. SELECTIVE ADDUCTOR RECOVERY AFTER LARYNGEAL NERVE INJURY
    Randal C Paniello; Fiscal Year: 2013
    ..One factor, neurotrophin 3 (NT-3), is known to favor regeneration of fast-twitch fibers such as those found in the adductor muscles of ..
  15. Neurotrophin mechanisms in neural development and disease
    Rejji Kuruvilla; Fiscal Year: 2013
    ....
  16. Roles of BDNF in Striatal Neurons and Relevance to Huntington's Disease
    Baoji Xu; Fiscal Year: 2013
    ..Results from this proposed research will provide insights into the regulation of striatal development and the pathogenesis of HD. ..
  17. GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHY
    David J Fink; Fiscal Year: 2012
    ..These studies are designed to develop novel agents that could be used to treat the disease effectively. ..
  18. Roles of BDNF in Striatal Neurons and Relevance to Huntington's Disease
    Baoji Xu; Fiscal Year: 2010
    ..Results from this proposed research will provide insights into the regulation of striatal development and the mechanism underlying selective degeneration of HD. ..
  19. Electrophysiological reporter for monitoring gene manipulations
    Jeffrey C Petruska; Fiscal Year: 2012
    ....
  20. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
    ....
  21. Preclinical Development of an NT3-expressing HSV Vector
    David J Fink; Fiscal Year: 2013
    ..abstract_text> ..
  22. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
    ....
  23. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
    ..These studies will provide new insights into the role of TH in brain development, which may have clinical importance in cretinism and infantile hypothyroidism. ..
  24. Neuronal subsets in the geniculate ganglion
    Albert Farbman; Fiscal Year: 2005
    ..We shall use in vitro and in vivo methods to relate changes in trk expression during development to other major developmental events. ..
  25. NEUROTROPHINS IN NEURONAL SURVIVAL AND DIFFERENTIATION
    Xin Liu; Fiscal Year: 2004
    ..In vitro experiments suggest that neurotrophins modulate CNS neuronal survival and differentiation. Our neurotrophin knockout mice allow us to determine the roles of the various neurotrophins in vivo. ..
  26. GROWTH FACTORS IN MAMMALIAN EYE DEVELOPMENT
    Jeffrey Bennett; Fiscal Year: 2002
    ..These studies should provide novel insight into the molecular genetics of eye development, potentially broaden our understanding of degenerative eye disorders and open new avenues for their treatment with growth factors. ..
  27. Neurotrophic factors and excitability
    Grant Nicol; Fiscal Year: 2007
    ..A fundamental understanding of such events could lead to better designed compounds and therapies to facilitate the treatment of chronic inflammatory conditions. [unreadable] [unreadable]..
  28. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....
  29. NEURONAL SURVIVAL AND DIFFERENTIATION IN RETINAL EXPLANT
    Dennis Rickman; Fiscal Year: 2002
    ..All understanding of the role of neurotrophins, and their mechanism of action, will provide insights into the potential therapeutic uses of neurotrophins in the treatment of retinal degenerative diseases. ..
  30. Effects of Chondroitinase and Training in Acute SCI
    Anindita Ganguly; Fiscal Year: 2005
    ..by increases in the levels of expression of neurotrophins such as brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) and neurotrophin 4 (NT-4)...
  31. PRENATAL INFECTION, BRAIN DEVELOPMENT AND SCHIZOPHRENIA
    John Gilmore; Fiscal Year: 2003
    ....
  32. Neurotrophin regulation of peripheral neurons
    LORI ISAACSON; Fiscal Year: 2002
    ..These results will provide information regarding the regulatory influences of neurotrophins and will provide support for a role for glial cells in neurotrophin regulation. ..
  33. NEUROTROPHIN-3 IN SENSORY RECEPTOR ORGAN DEVELOPMENT
    ROBIN KRIMM; Fiscal Year: 2000
    ..g., diabetic neuropathies. ..
  34. GENE DELIVERY FOR SPIRAL CORD INJURY REPAIR
    H Shine; Fiscal Year: 2004
    ..Genes for neurotrophin 3 (NT-3), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF)..
  35. Neurotrophins and Cocaine-Induced Neuronal Plasticity
    Guohua Yue; Fiscal Year: 2006
    ..abstract_text> ..
  36. EX VIVO SCHWANN CELL GENE THERAPY FOR CNS REPAIR
    Mark Tuszynski; Fiscal Year: 2000
    ..3) Determine whether primary Schwann cells genetically modified to express and secrete augmented amounts of human NGF will rescue degenerating host cholinergic neurons in the brain. ..
  37. REGULATION OF POSTNATAL CORTICAL MULTIPOTENT PROGENITORS
    MARK MEHLER; Fiscal Year: 2002
    ....
  38. MOLECULAR CONTROL OF THE GROWTH OF THE MEDULLOBLASTOMA
    Scott Pomeroy; Fiscal Year: 2000
    ..By testing whether Shh/Ptc and NT-3/TrkC collaborate to regulate the growth of the tumors, these experiments ultimately aim to define critical determinants of medulloblastoma growth, which have until now been poorly understood. ..
  39. THERAPY OF SPINAL CORD INJURY WITH NEUROTROPHIC FACTORS
    Deborah Hall; Fiscal Year: 1999
    ..abstract_text> ..
  40. CONTROL OF NT-3 EXPRESSION IN HIPPOCAMPUS
    ALISON VIGERS; Fiscal Year: 1999
    ....
  41. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2002
    ..We will test the system in a primate model, and develop human cells towards beginning Phase I clinical trials. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  42. HYPOTHALAMIC RECONSTRUCTION USING NEURAL PRECURSOR CELLS
    WILLIAM SCHWARTZ; Fiscal Year: 2003
    ....
  43. Egr genes in sympathetic nervous system development
    Laurie Eldredge; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. CONDITIONAL MUTAGENESIS IN ADDICTION CIRCUITRY
    Schahram Akbarian; Fiscal Year: 2004
    ..abstract_text> ..
  45. TRAFFICKING OF NEUROTROPHIC FACTORS
    CHRISTOPHER VON BARTHELD; Fiscal Year: 2000
    ..Neurotrophins are important regulators during the development of the visual system as well as potential therapeutic agents in degenerative retinal disease and after optic nerve injury. ..
  46. CNS NORADRENERGIC NEURONS--TROPHIC FACTORS
    ANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 1999
    ....
  47. AMELIORATION OF FETAL ALCOHOL EFFECTS
    JOHN HANNIGAN; Fiscal Year: 2004
    ..The results could have direct implications for the development of effective and appropriate treatments for FAS/ARNDs in children. ..
  48. A Protein-Polymer Approach to Neural Tissue Regeneration
    Kim Janda; Fiscal Year: 2005
    ..We envisage that the initial studies described herein will serve as the foundation for further studies in our laboratory in the design and chemical synthesis of biomimetic tissue regeneration matrices. ..
  49. Role of sphingosine-1-phosphate in oligodendrocytes
    HARSIMRAN SAINI; Fiscal Year: 2005
    ..A better understanding of the signaling pathways involved in OLG development will offer new avenues for the treatment of demyelinating conditions such as multiple sclerosis ..
  50. NEUROTROPHIN CONTROL OF REM SLEEP
    Jack Yamuy; Fiscal Year: 2004
    ..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
  51. Regulatory Molecules in Enteric Nervous System
    ALCMENE CHALAZONITIS; Fiscal Year: 2006
    ....
  52. MECHANISMS OF SYMPATHETIC NEURON SPECIFICATION
    Maya Sieber Blum; Fiscal Year: 2004
    ..Both types of drug easily cross the placenta and can cause autonomic disturbances in infants born to mothers who have been treated with the antidepressant, or who have used cocaine during pregnancy. ..
  53. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  54. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  55. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004
    ..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
  57. STEM CELL FACTOR ACTION IN NEURAL CREST DEVELOPMENT
    Maya Sieber Blum; Fiscal Year: 2003
    ..However, the newly detected additional roles of SCF in maintaining stem cells, up-regulating neurotrophin receptors and promoting sensory neurogenesis suggest additional defects in human piebaldism that remain to be elucidated. ..
  58. IMPROVED CELL COUNTING USING THE OPTICAL DISECTOR
    CHRISTOPHER VON BARTHELD; Fiscal Year: 2004
    ....
  59. INVERSE METASTATIC MODALITIES BY HEPARANASES
    Dario Marchetti; Fiscal Year: 2005
    ..They will provide a framework for the development of polysaccharide-based anti-cancer molecules as important prognostic tools and diagnostic screens for metastatic detection, diagnosis and treatment. ..
  60. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
    ..Moreover, it will form an essential foundation for further research on the development of, and the structural and functional organization of, the diverse systems that form the vagal sensorium. ..
  61. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
  62. BEHAVIORALLY INDUCED NEUROCHEMICAL PLASTICITY
    Christine Gall; Fiscal Year: 2001
    ..The proposed work will provide a first test for their presence in regions engaged learning behaviors. ..
  63. Eph/ephrin Signaling in Taste Nerve Development
    MICHAEL ROCHLIN; Fiscal Year: 2006
    ..We will place beads soaked in diffusible (Fc) constructs of these molecules near the ganglion to test their impact on nerve divergence. [unreadable] [unreadable] [unreadable]..
  64. Calcitriol and Methamphetamine Neurotoxicity
    Wayne Cass; Fiscal Year: 2008
    ..Furthermore, if calcitriol is effective, it could have therapeutic applications in other disease processes where there is a loss of monoamine neurons, such as in Parkinson's disease. [unreadable] [unreadable] [unreadable]..
  65. A Novel Gene Network Controlling Mammalian Puberty
    Sergio Ojeda; Fiscal Year: 2006
    ..Although siRNAs are widely used to perturb gene expression in mammalian cells, the methodology to achieve long-term silencing effects in vivo is still in its infancy. [unreadable] [unreadable]..