Genomes and Genes
Summary: A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.
Publications330 found, 100 shown here
- Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscleF Gomez-Pinilla
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
Eur J Neurosci 13:1078-84. 2001..These results show that neuromuscular activity has specific effects on the BDNF and NT-3 systems, and that repetitive exercise affects the magnitude and stability of these responses...
- Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult ratsLiudmila N Novikova
Department of Integrative Medical Biology, Section of Anatomy, Umea University, SE 901 87 Umea, Sweden
J Comp Neurol 452:255-63. 2002....
- Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injuryKook In Park
Department of Pediatrics, and the Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea
Exp Neurol 199:179-90. 2006....
- Severe sensory and sympathetic deficits in mice lacking neurotrophin-3I Farinas
Department of Physiology, University of California School of Medicine, San Francisco 94143 0724
Nature 369:658-61. 1994..16). In particular, neurotrophin-3 is essential for survival of sympathetic and sensory neurons that later become dependent on nerve growth factor or brain-derived neurotrophic factor...
- NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursorsN Francis
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
Dev Biol 210:411-27. 1999..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor...
- Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesisL Tessarollo
Neural Development Group, ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 94:14776-81. 1997..The similarities in cardiac defects observed in the trkC and NT-3 null mutant mice indicate that the trkC receptor mediates most NT-3 effects on the cardiac neural crest...
- Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neuronsJacob Tauris
Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
Eur J Neurosci 33:622-31. 2011..However, our results suggest that proNT3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex...
- Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervationK M Albers
Department of Pathology, University of Kentucky Medical Center, Lexington 40536, USA
J Cell Biol 134:487-97. 1996..These results indicate that in vivo overexpression of NT-3 by the epidermis enhances the number of sensory and sympathetic neurons and the development of selected sensory endings of the skin...
- Neurotrophins and trk-receptors in adult rat spinal motoneurons: differences related to cell size but not to 'slow/fast' specializationS Copray
Department of Medical Physiology, University of Groningen, The Netherlands
Neurosci Lett 289:217-20. 2000..slow' categories of motoneurons...
- The effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cellsXiaoguang Li
Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069, China
Biomaterials 30:4978-85. 2009..These results may provide an experimental basis for the maximum replacement of dead neurons by neural stem cell transplant after spinal cord injury (SCI)...
- Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitroL N Pettingill
The Bionic Ear Institute, 384 Albert Street, East Melbourne, Australia 3002
Neuroscience 152:821-8. 2008..which were genetically modified to over-express the neurotrophins brain-derived neurotrophic factor (BDNF) or neurotrophin 3 (Ntf3, formerly NT-3) could support SGN survival in an in vitro model of deafness...
- Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3James M Massey
School of Medicine, University of Louisville, Louisville, KY 40292, USA
Exp Neurol 209:426-45. 2008..These results demonstrate both an additional challenge and potential treatment strategy for successful functional pathway reconstruction after SCI...
- Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized catsVanessa S Boyce
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Neurophysiol 98:1988-96. 2007..Finally, the results show that transplants beneficial in rodents are applicable to larger mammals...
- Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampusM Torasdotter
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden
Behav Brain Res 93:83-90. 1998....
- Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitroQiong Wang
Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA
J Neurosci 31:7938-49. 2011....
- Functional regeneration of sensory axons into the adult spinal cordM S Ramer
Neuroscience Research Centre, Guy s, King s and St Thomas School of Biomedical Sciences, London, UK
Nature 403:312-6. 2000..Neurotrophic factor treatment may thus serve as a viable treatment in promoting recovery from root avulsion injuries. I..
- Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injuryJ S Guo
Division of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou 510080, P R China
Spinal Cord 45:15-24. 2007..An animal model of transected spinal cord injury (SCI) was used to test the hypothesis that cografted neural stem cells (NSCs) and NT-3-SCs promote morphologic and functional recoveries of injured spinal cord...
- Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5X Liu
Department of Pathology and Molecular Medicine, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
Dev Dyn 218:94-101. 2000..Our results suggest that neurotrophins are essential for the survival of most peripheral sensory neurons and affect the survival of a small portion of motor neurons during embryogenesis...
- Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's diseaseSusanne A Wolf
Max Delbruck Center for Molecular Medicine, Berlin Buch, Charite University Medicine, Berlin, Germany
Biol Psychiatry 60:1314-23. 2006..Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD)...
- Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neuronsA Chalazonitis
Department of Anatomy and Cell Biology, Columbia University, New York, New York 10032, USA
J Neurosci 21:5620-36. 2001..A neuropoietic cytokine (CNTF) interacted with NT-3 in vitro, and if applied sequentially, compensated for NT-3 withdrawal. These observations indicate that NT-3 is required for the normal development of the ENS...
- Nerve growth factor and asthmaCaroline Olgart Hoglund
Institut National de la Santé et de la Recherche Médicale Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, B P 24, 67 401 Illkirch Cedex, France
Pulm Pharmacol Ther 15:51-60. 2002
- Neurotrophin 3 promotes purification and proliferation of olfactory ensheathing cells from human noseJohn I Bianco
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Nathan, Queensland 4111, Australia
Glia 45:111-23. 2004..on three neurotrophic factors, namely nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT3)...
- Dependence of developing group Ia afferents on neurotrophin-3J Kucera
Department of Neurology, Boston University Medical Center, Massachusetts 02118 2394, USA
J Comp Neurol 363:307-20. 1995..Thus, developing Ia neurons may be dependent on NT-3 intrinsic to the DRGs before they reach a stage of potential dependence on NT-3 retrogradely derived from skeletal muscles or spinal motor neurons...
- Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivoAnna Stenqvist
Unit of Molecular Neurobiology, MBB, Karolinska Institutet, Stockholm, Sweden
EMBO Rep 6:973-8. 2005..However, several in vitro and in vivo studies of null mutant mice have suggested that neurotrophin 3 (NT 3) also signals through the non-preferred TrkB receptor...
- Enhancing proprioceptive input to motoneurons differentially affects expression of neurotrophin 3 and brain-derived neurotrophic factor in rat hoffmann-reflex circuitryOlga Gajewska-Wozniak
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland
PLoS ONE 8:e65937. 2013The importance of neurotrophin 3 (NT-3) for motor control prompted us to ask the question whether direct electrical stimulation of low-threshold muscle afferents, strengthening the proprioceptive signaling, could effectively increase the ..
- A role for NT-3 in the hyperinnervation of neonatally wounded skinSimon Beggs
Programme in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
Pain 153:2133-9. 2012..We conclude that upregulation of NT-3 in neonatally wounded skin is a critical factor mediating the sensory nerve sprouting that underlies hypersensitivity and pain following skin injury...
- Glutamate stimulates neurotrophin expression in cultured Müller cellsSara Taylor
Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Brain Res Mol Brain Res 111:189-97. 2003..Moreover, the increased secretion of neurotrophic factors and upregulation of L-glutamate/L-aspartate transporter (GLAST) expression in Müller cells may protect retinal neurons from glutamate toxicity...
- The neurotrophin receptor p75NTR as a positive modulator of myelinationJose M Cosgaya
Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Building, Stanford, CA 94305, USA
Science 298:1245-8. 2002..Thus p75NTR and TrkC receptors have opposite effects on myelination...
- Complementary roles of BDNF and NT-3 in vestibular and auditory developmentP Ernfors
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
Neuron 14:1153-64. 1995..These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems...
- Neuroprotection of neurotrophin-3 against focal cerebral ischemia/reperfusion injury is regulated by hypoxia-responsive element in ratsJ Zhang
Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, PR China
Neuroscience 222:1-9. 2012..To avoid unexpected side effects, 5HRE-controlled gene expression might be a useful tool for gene therapy of ischemic disorders in the central nervous system...
- NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cordE J Bradbury
Neuroscience Research Centre, Guys, Kings and St Thomas School of Biomedical Sciences, Division of Physiology, Lambeth Palace Road, London E1 4NS, UK
Eur J Neurosci 11:3873-83. 1999....
- Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron developmentW M ElShamy
Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Doktorsringen 12A, Karolinska Institute, 171 77 Stockholm, Sweden
J Neurosci 17:8667-75. 1997....
- Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditionsM Torasdotter
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Sweden
Neurosci Lett 218:107-10. 1996..These results indicate a possible role for NT-3 in synaptic plasticity...
- The effect of the dosage of NT-3/chitosan carriers on the proliferation and differentiation of neural stem cellsZhaoyang Yang
The School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
Biomaterials 31:4846-54. 2010....
- The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protectionAndrew K Wise
The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, Victoria 3002, Australia
Hear Res 278:69-76. 2011..Clinically, there remains a window of opportunity in which NT gene therapy can provide ongoing trophic support for SGNs...
- Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread painNeena K Sharma
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Mail Stop 2002, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Phys Ther 90:714-25. 2010..However, the molecular basis for the positive actions of exercise remains poorly understood. Recent studies suggest that neurotrophin-3 (NT-3) may act in an analgesic fashion in various pain states...
- Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injuryHannah M Tuinstra
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 3120, USA
Biomaterials 33:1618-26. 2012..Combining gene delivery with biomaterials to provide physical guidance and create a permissive environment can provide a platform to enhance axonal growth and promote regeneration...
- trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3F Lamballe
Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
Cell 66:967-79. 1991..These results indicate that gp145trkC may play an important role in mediating the neurotrophic effects of NT-3...
- Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomyLu Ting Kuo
Department of Molecular Neuroscience, Division of Neuropathology, Institute of Neurology, London WC1N 3BG, UK
J Comp Neurol 482:320-32. 2005..Our results suggest that the presence of nestin in DRG neurons after nerve injury is due to recent differentiation and that exogenous NT-3 may prevent neuron loss by stimulating this process, rather than preventing neuron death...
- Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neuronsMitchell Kundel
Department of Cell Biology, Yale University, New Haven, Connecticut 06520 8103, USA
J Neurosci 29:13630-9. 2009..Together, these results suggest that CPEB1 regulates beta-catenin synthesis in neurons and may contribute to neuronal morphogenesis...
- Immune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injuryQin Chen
Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA
Exp Neurol 209:497-509. 2008..These observations demonstrate that processes associated with immune-mediated wound healing play a role in NT-3-induced neuroplasticity after injury...
- Neurotrophins promote regeneration of sensory axons in the adult rat spinal cordM Oudega
The Miami Project to Cure Paralysis, University of Miami School of Medicine, PO Box 016960, R 48, Miami, FL 33136, USA
Brain Res 818:431-8. 1999..These findings suggest that injured ascending sensory axons are responsive to all three neurotrophins and confirm our previous findings that neurotrophic factors can promote regeneration in the adult central nervous system...
- p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophinsA M Davies
School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
Neuron 11:565-74. 1993..These findings indicate that p75 enhances the sensitivity of NGF-dependent cutaneous sensory neurons to NGF and may explain, at least in part, the cutaneous sensory abnormalities of mice homozygous for the p75 mutation...
- Complementary actions of BDNF and neurotrophin-3 on the firing patterns and synaptic composition of motoneuronsMaría A Davis-López de Carrizosa
Departamento de Fisiologia y Zoologia, Facultad de Biologia, Universidad de Sevilla, Sevilla, Spain
J Neurosci 29:575-87. 2009..These trophic actions could be responsible, in part, for synaptic rearrangements that alter circuit stability and synaptic balance during plastic events of the brain...
- Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic miceD J Liebl
Developmental Biology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9133, USA
J Neurosci 17:9113-21. 1997..We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes...
- Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychosesN Durany
Laboratory for Neurochemistry, University of Wurzburg, Wurzburg, Germany
Schizophr Res 52:79-86. 2001....
- Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervationM S Airaksinen
Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg Martinsried, Republic of Germany
Neuron 16:287-95. 1996..Thus, NT-3 is essential for the maintenance of specific cutaneous afferents known to subserve fine tactile discrimination in humans...
- NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patientsZ Sahenk
Department of Neurology, Ohio State University, Columbus, OH, USA
Neurology 65:681-9. 2005..Neurotrophin-3 (NT-3), an important component of the Schwann cell (SC) autocrine survival loop, could correct these deficiencies...
- Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult ratsJeffrey C Petruska
Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, NY 11794, USA
Eur J Neurosci 32:997-1005. 2010..This approach to neurotrophin delivery could be useful in modifying spinal function after injury...
- Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitroI Gavazzi
Department of Developmental Neurobiology, King s College London, Guy s Campus, UK
Eur J Neurosci 11:3405-14. 1999..BDNF exerted an inhibitory effect on growth, and both BDNF and NT-3 could partially block some of the growth-promoting effects of NGF on specific neuronal subpopulations...
- Localization of TrkC to Schwann cells and effects of neurotrophin-3 signaling at neuromuscular synapsesDarren M Hess
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6074, USA
J Comp Neurol 501:465-82. 2007..Together, these results demonstrate that NT3 expression is developmentally regulated in skeletal muscle and may modulate the number of Schwann cells at neuromuscular synapses...
- Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb functionB Blits
Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Neuroscience 118:271-81. 2003..Our results suggest that AAV vector-mediated overexpression of BDNF and NT-3 in the cord caudal to a Schwann cell bridge modified the local lumbar axonal circuitry, which was beneficial for locomotor function...
- Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivoI Farinas
Department of Physiology, University of California, San Francisco 94143, USA
Neuron 21:325-34. 1998..Results also indicate that survival of cells expressing both receptors can be maintained by activation of either one alone. NT-3 can thus activate more than one Trk receptor in vivo, which when coexpressed are functionally redundant...
- Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashionB Fritzsch
Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
J Neurosci 17:6213-25. 1997Essential functions of neurotrophin 3 (NT-3) in regulating afferent and efferent innervation of the cochlea have been characterized by comparison of normal and NT-3 mutant mice...
- Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNSV Lessmann
Department of Molecular Neurobiochemistry, Ruhr Universitat Bochum, Germany
Gen Pharmacol 31:667-74. 1998..Thus, neurotrophins might operate as locally released feedback modulators of synaptic transmission, and this could be a cellular correlate for certain aspects of information processing in the mammalian brain...
- An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injuryJ Piantino
Department of Neurosurgery, Children s Hospital, Boston, MA 02115, USA
Exp Neurol 201:359-67. 2006..These studies demonstrate the effectiveness of hydrogel technology as a clinically feasible delivery system to promote regeneration and enhance functional outcome after spinal cord injury...
- Co-transplantation of neural stem cells and NT-3-overexpressing Schwann cells in transected spinal cordXuebao Zhang
Department of Histology and Embryology, Institute of Spinal Cord Injury, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
J Neurotrauma 24:1863-77. 2007..However, this pre-differentiation of NSCs in vitro only mildly improved neuronal differentiation of NSCs in vivo...
- Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cordAndres Hurtado
The Miami Project to Cure Paralysis, University of Miami School of Medicine, P O Box 016960, R 48, Miami, FL 33136, USA
Biomaterials 27:430-42. 2006..For the development of SC-seeded macroporous scaffolds that effectively promote axonal regeneration in the injured spinal cord, the survival and/or total number of SCs in the scaffold needs to be improved...
- Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injuryPhilip J Johnson
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
Biotechnol Bioeng 104:1207-14. 2009..These results demonstrate that the controlled release of NT-3 from fibrin scaffolds can enhance neural fiber sprouting even when treatment is delayed 2 weeks following injury...
- Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglionHelge Rask-Andersen
Department of Otosurgery, Uppsala University Hospital, S 751 85 Uppsala, Sweden
Hear Res 203:180-91. 2005..Transplantation of progenitor cells together with established means to induce neural differentiation and fiber growth may facilitate strategies for better repair and treatment of auditory neuronal damage...
- Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cordZhe Ying
Department of Physiological Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
Brain Res 987:93-9. 2003....
- SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in ratsTracy M Clement
Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA
Biol Reprod 85:277-84. 2011b>Neurotrophin 3 (Ntf3) is expressed in Sertoli cells and acts as a chemo-attractant for cell migration from the mesonephros into the developing testis, a process critical to the early morphological events of testis cord formation...
- Hypothermia-induced neurite outgrowth is mediated by tumor necrosis factor-alphaKatharina R L Schmitt
Clinic for Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum, Berlin, Germany
Brain Pathol 20:771-9. 2010..These data suggest that hypothermia not only exerts protective effects in the CNS but may also support neurite outgrowth as a potential mechanism of regeneration...
- Local and target-derived actions of neurotrophins during peripheral nervous system developmentP Ernfors
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Cell Mol Life Sci 58:1036-44. 2001....
- Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cordQin Chen
Center for Cell and Gene Therapy and Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA
J Neurotrauma 23:1254-60. 2006..Since the processes of WD would have resolved within 4 months after injury, these data demonstrate that products of WD are a potential source of the co-inducing signals that support neuroplasticity in the presence of NT-3...
- Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3Andrew K Wise
The Bionic Ear Institute, East Melbourne 3002, Australia
J Comp Neurol 487:147-65. 2005..These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf...
- Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cellsH E Gruber
Department of Orthopaedic Surgery, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
Biotech Histochem 87:506-11. 2012..IL-1ß exposure in three-dimensional culture significantly increased expression of neurotrophin 3, brain-derived neurotrophic factor, and neuropilin 2 compared to controls...
- Reduction of NT-3 or TrkC results in fewer putative vagal mechanoreceptors in the mouse esophagusMarion Raab
Department of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
Auton Neurosci 108:22-31. 2003..This concurs with their proposed function as vagal mechanosensors crucial for reflex peristalsis...
- Tool-use learning selectively induces expression of brain-derived neurotrophic factor, its receptor trkB, and neurotrophin 3 in the intraparietal multisensorycortex of monkeysHidetoshi Ishibashi
Section of Cognitive Neurobiology, Department of Maxillofacial Biology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8549, Tokyo, Japan
Brain Res Cogn Brain Res 14:3-9. 2002..These results suggest that these factors are involved in the reorganization of the somatosensory and visual signals in the anterior bank of the intraparietal sulcus when monkeys are learning the use of the tool...
- A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3Tan Li
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
Toxicol Sci 134:111-24. 2013..6-OH-PBDE-47 also inhibited the proneuronal differentiation effect of neurotrophin 3 (NT3) and NT3 activation of ERK5...
- Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in miceAsaka Saito
Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Environ Toxicol 26:224-32. 2011..These findings demonstrate that FA has more potent irritancy against skin than toluene or xylene and suggest that the Th2 response, neurotrophins and TRPV-1 play important roles in FA-induced skin inflammation...
- NT-3 expression in spared DRG and the associated spinal laminae as well as its anterograde transport in sensory neurons following removal of adjacent DRG in catsTing Hua Wang
Institute of Neurological Disease, West China Hospital, Sichuan University, Chendu 610041, China
Neurochem Res 33:1-7. 2008..The above results indicate that DRG may be a source of neurotrophic factors such as NT-3 to the spinal cord, and may contribute to plasticity in the spinal cord after injury...
- Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophilsO Noga
Allergy and Asthma Clinic, Charite, Campus Virchow, Humboldt University, Berlin, Germany
Clin Exp Allergy 32:1348-54. 2002..Recent studies have shown that nerve growth factor (NGF) can act on several immune cells as well as residential cells. But little is known about their role in modulating eosinophil function via activation of high-affinity receptors...
- Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathwaysFanie Barnabe-Heider
Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
J Neurosci 23:5149-60. 2003..Thus, neurotrophins made by cortical progenitor cells themselves signal through the TrkB and TrkC receptors to mediate cortical progenitor cell survival and neurogenesis via two distinct downstream signaling pathways...
- Pro-inflammatory cytokines upregulate the skin immunoreactivity for NGF, NT-3, NT-4 and their receptor, p75NTR in vivo: a preliminary reportHolger Bläsing
Department of Dermatology, University Hospital Eppendorf, Hamburg University, Martinistrasse 52, 20246, Hamburg, Germany
Arch Dermatol Res 296:580-4. 2005..This raises the question to which extent several of the recognized cutaneous effects of IFNgamma, IL-1beta and TNF-alpha are mediated indirectly via modulating the expression of selected NTs and/or NTRs...
- Expression and function of neurotrophins and their receptors in cultured human keratinocytesA Marconi
Institute of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
J Invest Dermatol 121:1515-21. 2003..Finally, neurotrophins other than nerve growth factor fail to protect human keratinocytes from ultraviolet B-induced apoptosis. This work delineates a functional neurotrophin network, which may contribute to epidermal homeostasis...
- Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathwayJunji Yamauchi
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
Proc Natl Acad Sci U S A 100:14421-6. 2003..Here we show that migration of Schwann cells, isolated from sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-derived neurotrophic factor...
- Postnatal regulation of limb proprioception by muscle-derived neurotrophin-3M D Taylor
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Comp Neurol 432:244-58. 2001..However, our results also show that NT-3 may be therapeutic for proprioceptive axons immediately after nerve injury by delaying axon degeneration...
- Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochleaRachael T Richardson
The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
Hear Res 198:25-35. 2004..NT-3 microspheres remained in the cochlea for at least 28 days, suggesting a low clearance rate within cochlear tissues...
- Secretion of intrinsic cues controls repulsion of nociceptive neuronsSonia Montazeri
Neuroscience Research Center, Charite, Central Campus, Department of Molecular Neurobiology, Hufelandweg 14, 10177 Berlin, Germany
Mol Cell Neurosci 24:595-602. 2003..Our data provide evidence that the segmented pattern of skin nociceptive sensory maps is supported by unknown intrinsic cues released from the sensory axons themselves...
- Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axonsR O'CONNOR
Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143, USA
Neuron 24:165-78. 1999....
- Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptorsSabrina L McIlwrath
Department of Neurobiology, School of Medicine, University of Pittsburgh, 3500 Terrace St, Pittsburgh, PA 15261, USA
Eur J Neurosci 26:1801-12. 2007..These results indicate that cutaneous NT3 overexpression alters the response properties of specific cutaneous sensory neurons, and that these changes may be due to the modulation of putative mechanosensitive ion channels...
- Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formationNoriyoshi Usui
Department of Physiological Sciences, School of Life Science, The GraduateUniversity for Advanced Studies SOKENDAI, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
Development 139:1125-32. 2012..5. To understand the motoneuron-derived factor that regulates sensory neuron development, we focused on neurotrophin 3 (Ntf3; NT-3), because Ntf3 and its receptors (Trk) are strongly expressed in motoneurons and sensory neurons, ..
- Neurotrophin-3 promotes the differentiation of muscle spindle afferents in the absence of peripheral targetsR A Oakley
Department of Neurobiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 17:4262-74. 1997..Together, our results indicate that NT3 signaling is both necessary and sufficient for the development of the proprioceptive phenotype, even in the absence of other signals from limb muscle...
- Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tractEdward A Fox
Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
Cell Tissue Res 340:267-86. 2010....
- Decreased NT-3 plasma levels and platelet serotonin content in patients with hypochondriasisNatascia Brondino
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
J Psychosom Res 65:435-9. 2008..Although NTs have been associated to a variety of mental disorders, the potential role of NT alterations in hypochondriasis (HC) has never been investigated...
- Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCIJenny Fortun
The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA
J Neurotrauma 26:941-53. 2009..Muscle injections of AAV5-neurotrophin 3 (NT3) resulted in a significant increase in the levels of NT3 in the cervical enlargement, compared to those ..
- Prenatal exposure to elevated NT3 disrupts synaptic selectivity in the spinal cordZhi Wang
Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Neurosci 27:3686-94. 2007..These results indicate that prenatal exposure to elevated levels of NT3 disrupts the normal mechanisms responsible for synaptic selectivity in the stretch reflex circuit...
- Peripheral projections of rat primary sensory neurons immunoreactive for neurotrophin 3X F Zhou
Centre for Neuroscience, Flinders University of South Australia, Adelaide, Australia
J Comp Neurol 363:69-77. 1995..We have recently reported that a subpopulation of large diameter sensory neurons of the rat contain neurotrophin 3-like immunoreactivity (NT3-ir)...
- Development and specification of muscle sensory neuronsH H Chen
Department of Neurobiology, School of Medicine, University of Pittsburgh, Bioscience Tower W1452, 3500 Terrace Street, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Neurobiol 9:405-9. 1999..The explosion of new information on neurotrophins, however, has revealed that neurotrophin 3 (NT3) is critically involved in several aspects of this development, including the initial differentiation, ..
- Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous systemT Ringstedt
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Development 124:2603-13. 1997..These findings suggest novel roles for NT3 in differentiation of proprioceptive neurons, target invasion and formation of Ia projections which are independent from its effects on neuronal survival...
- Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptorsC S von Bartheld
Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
J Neurosci 16:2995-3008. 1996....
- Herbal formula SYJN increases neurotrophin-3 and nerve growth factor expression in brain regions of rats exposed to chronic unpredictable stressQing Qiu Mao
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
J Ethnopharmacol 131:182-6. 2010..The present study aimed to investigate whether neurotrophin-3 (NT-3) and nerve growth factor (NGF) are involved in the antidepressant-like action of SYJN by using the same depressive model in rats...
- Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injuryP Lu
Department of Neurosciences, University of California at San Diego, La Jolla 92093 0626, USA
Exp Neurol 181:115-29. 2003..Thus, stem cells can promote host neural repair in part by secreting growth factors, and their regeneration-promoting activities can be modified by gene delivery...
- Direct and indirect effects of neuropeptide Y and neurotrophin 3 on myelination in the neonatal brainsRyuju Hashimoto
Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
Brain Res 1373:55-66. 2011..In cultured oligodendroglioma-derived B12 cells, NPY didn't influence the MBP-mRNA expression, while neurotrophin 3 (NT3) increased MBP mRNA via receptor-type tyrosine kinase type C (Trk C)...
- Expression of neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral folliclesGalia Oron
Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Fertil Steril 95:2056-62. 2011To investigate the expression of neurotrophin 3 (NT3) and its receptor tropomyosin-related kinase C (TrkC) in human preantral follicles. Neurotrophins appear to play important roles in preantral follicles...
- Differential regulation of axon outgrowth and reinnervation by neurotrophin-3 and neurotrophin-4 in the hippocampal formationDaniel Hechler
Institute for Cell Biology and Neurobiology, Center for Anatomy, Charite, Universitatsmedizin, Berlin, Germany
Exp Brain Res 205:215-21. 2010..These results suggest that endogenous and exogenous NT-3 and NT-4 differentially influence neurite growth depending on the presence or absence of target tissue...
- Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neuronsRungtip Soiampornkul
Neuro Behavioral Biology Center, Institute of Science and Technology for Development, Mahidol University, Salaya Campus Nakorn Pathom, Thailand
Brain Res 1188:189-97. 2008....
- Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneuronsVictor L Arvanian
Dept of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Bldg Rm 550, Stony Brook, NY 11794 5230, USA
J Neurophysiol 92:2394-404. 2004..This approach might be useful for enhancing the function of fibers surviving in the damaged spinal cord...
- Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal ratVictor L Arvanian
Department of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Building, Stony Brook, NY 11794 5230, USA
Exp Neurol 197:347-52. 2006....
- Combined treatment with neurotrophin-3 and LSD facilitates behavioral recovery from double-hemisection spinal injury in neonatal ratsVictor L Arvanian
Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794 5230, USA
J Neurotrauma 23:66-74. 2006..Rearing frequency reached sham control levels by P40. Our results suggest this combination treatment may be a promising new strategy for facilitating recovery from moderate spinal cord injury...
- Analysis of Kinesins Mediating Neurotrophin TransportRafal Butowt; Fiscal Year: 2006..abstract_text> ..
- NIH Director's Pioneer AwardERICH JARVIS; Fiscal Year: 2009..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
- Repair of Airway Epithelium Following Chlorine Lung InjuryGary W Hoyle; Fiscal Year: 2011..multiple neurotrophin ligands, including nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin 3. The hypothesis to be tested in the proposed studies is that NGFR controls the proliferation, survival, and ..
- DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATESNed H Kalin; Fiscal Year: 2013..Relevant to this, we have amassed evidence that activity of the neurotrophin 3 (NTF3)/neurotrophic tyrosine kinase receptor type 3 (NTRK3) neuroplasticity system in the CeA is inversely ..
- Cellular therapy for the inner earAlbert S Edge; Fiscal Year: 2013..abstract_text> ..
- Bioengineered scaffolds for peripheral nerve repairRavi V Bellamkonda; Fiscal Year: 2010..include biochemical cues, such as growth stimulatory extracellular matrix (laminin-1) and trophic protein (Neurotrophin 3, NT-3)...
- Intracellular Target of Sphingosine-1-PhosphateGRAHAM M STRUB; Fiscal Year: 2010..Deciphering the mechanism of action of this sphingolipid metabolite could provide clues for the prevention and treatment of devastating human neurodegenerative diseases. ..
- NT-3 gene therapy to improve peripheral nerve function induced by genetic defectZarife Sahenk; Fiscal Year: 2012DESCRIPTION (provided by applicant): The premise for this proposal is that AAV1 mediated gene delivery of neurotrophin 3 (NT-3) will provide clinical improvement in the most common inherited neuropathy, Charcot-Marie-Tooth neuropathy ..
- Mechanism of Neurotrophin Latency Response in a HSV1 Vestibular Neuritis ModelPAMELA CAROL ROEHM; Fiscal Year: 2013....
- Neurotrophin Specificity and Function in the Taste SystemChristopher Nosrat; Fiscal Year: 2009..We have shown that two members of the neurotrophin family, Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) play important roles in the innervation of the developing tongue...
- miR-200c Mediates Suppression of Anoikis Resistance by Targeting an Autocrine SigERIN NICOLE HOWE; Fiscal Year: 2012..Furthermore, neurotrophin 3 (NTF3), a ligand for TrkB has 2 predicted miR-200c binding sites in the 3'UTR...
- Neurotrophic Mechanisms in Retinal Ganglion Cell MaturationXiaorong Liu; Fiscal Year: 2011..the investigators will focus on the roles of two neurotrophins, Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3)...
- A Rational Approach to Stimulating Peripheral Nerve Regeneration Across CriticallRavi V Bellamkonda; Fiscal Year: 2013..abstract_text> ..
- SELECTIVE ADDUCTOR RECOVERY AFTER LARYNGEAL NERVE INJURYRandal C Paniello; Fiscal Year: 2013..One factor, neurotrophin 3 (NT-3), is known to favor regeneration of fast-twitch fibers such as those found in the adductor muscles of ..
- Neurotrophin mechanisms in neural development and diseaseRejji Kuruvilla; Fiscal Year: 2013....
- Roles of BDNF in Striatal Neurons and Relevance to Huntington's DiseaseBaoji Xu; Fiscal Year: 2013..Results from this proposed research will provide insights into the regulation of striatal development and the pathogenesis of HD. ..
- GENE TRANSFER FOR PREVENTION OF DIABETIC NEUROPATHYDavid J Fink; Fiscal Year: 2012..These studies are designed to develop novel agents that could be used to treat the disease effectively. ..
- Roles of BDNF in Striatal Neurons and Relevance to Huntington's DiseaseBaoji Xu; Fiscal Year: 2010..Results from this proposed research will provide insights into the regulation of striatal development and the mechanism underlying selective degeneration of HD. ..
- Electrophysiological reporter for monitoring gene manipulationsJeffrey C Petruska; Fiscal Year: 2012....
- Regulation of neurotrophin expression in the peripheryLORI ISAACSON; Fiscal Year: 2009....
- Preclinical Development of an NT3-expressing HSV VectorDavid J Fink; Fiscal Year: 2013..abstract_text> ..
- MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNSDominique Toran Allerand; Fiscal Year: 2000....
- THYROID HORMONE ACTION IN NEUROGENESISRichard Maas; Fiscal Year: 2001..These studies will provide new insights into the role of TH in brain development, which may have clinical importance in cretinism and infantile hypothyroidism. ..
- Neuronal subsets in the geniculate ganglionAlbert Farbman; Fiscal Year: 2005..We shall use in vitro and in vivo methods to relate changes in trk expression during development to other major developmental events. ..
- NEUROTROPHINS IN NEURONAL SURVIVAL AND DIFFERENTIATIONXin Liu; Fiscal Year: 2004..In vitro experiments suggest that neurotrophins modulate CNS neuronal survival and differentiation. Our neurotrophin knockout mice allow us to determine the roles of the various neurotrophins in vivo. ..
- GROWTH FACTORS IN MAMMALIAN EYE DEVELOPMENTJeffrey Bennett; Fiscal Year: 2002..These studies should provide novel insight into the molecular genetics of eye development, potentially broaden our understanding of degenerative eye disorders and open new avenues for their treatment with growth factors. ..
- Neurotrophic factors and excitabilityGrant Nicol; Fiscal Year: 2007..A fundamental understanding of such events could lead to better designed compounds and therapies to facilitate the treatment of chronic inflammatory conditions. [unreadable] [unreadable]..
- Ischemic Paraplegia: Modulation by Stem Cell ImplantMartin Marsala; Fiscal Year: 2005....
- NEURONAL SURVIVAL AND DIFFERENTIATION IN RETINAL EXPLANTDennis Rickman; Fiscal Year: 2002..All understanding of the role of neurotrophins, and their mechanism of action, will provide insights into the potential therapeutic uses of neurotrophins in the treatment of retinal degenerative diseases. ..
- Effects of Chondroitinase and Training in Acute SCIAnindita Ganguly; Fiscal Year: 2005..by increases in the levels of expression of neurotrophins such as brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) and neurotrophin 4 (NT-4)...
- PRENATAL INFECTION, BRAIN DEVELOPMENT AND SCHIZOPHRENIAJohn Gilmore; Fiscal Year: 2003....
- Neurotrophin regulation of peripheral neuronsLORI ISAACSON; Fiscal Year: 2002..These results will provide information regarding the regulatory influences of neurotrophins and will provide support for a role for glial cells in neurotrophin regulation. ..
- NEUROTROPHIN-3 IN SENSORY RECEPTOR ORGAN DEVELOPMENTROBIN KRIMM; Fiscal Year: 2000..g., diabetic neuropathies. ..
- GENE DELIVERY FOR SPIRAL CORD INJURY REPAIRH Shine; Fiscal Year: 2004..Genes for neurotrophin 3 (NT-3), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF)..
- Neurotrophins and Cocaine-Induced Neuronal PlasticityGuohua Yue; Fiscal Year: 2006..abstract_text> ..
- EX VIVO SCHWANN CELL GENE THERAPY FOR CNS REPAIRMark Tuszynski; Fiscal Year: 2000..3) Determine whether primary Schwann cells genetically modified to express and secrete augmented amounts of human NGF will rescue degenerating host cholinergic neurons in the brain. ..
- REGULATION OF POSTNATAL CORTICAL MULTIPOTENT PROGENITORSMARK MEHLER; Fiscal Year: 2002....
- MOLECULAR CONTROL OF THE GROWTH OF THE MEDULLOBLASTOMAScott Pomeroy; Fiscal Year: 2000..By testing whether Shh/Ptc and NT-3/TrkC collaborate to regulate the growth of the tumors, these experiments ultimately aim to define critical determinants of medulloblastoma growth, which have until now been poorly understood. ..
- THERAPY OF SPINAL CORD INJURY WITH NEUROTROPHIC FACTORSDeborah Hall; Fiscal Year: 1999..abstract_text> ..
- CONTROL OF NT-3 EXPRESSION IN HIPPOCAMPUSALISON VIGERS; Fiscal Year: 1999....
- Novel Ex Vivo Gene Therapy for Spinal Cord InjuryAlpa Trivedi; Fiscal Year: 2002..We will test the system in a primate model, and develop human cells towards beginning Phase I clinical trials. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- HYPOTHALAMIC RECONSTRUCTION USING NEURAL PRECURSOR CELLSWILLIAM SCHWARTZ; Fiscal Year: 2003....
- Egr genes in sympathetic nervous system developmentLaurie Eldredge; Fiscal Year: 2006..unreadable] [unreadable]..
- CONDITIONAL MUTAGENESIS IN ADDICTION CIRCUITRYSchahram Akbarian; Fiscal Year: 2004..abstract_text> ..
- TRAFFICKING OF NEUROTROPHIC FACTORSCHRISTOPHER VON BARTHELD; Fiscal Year: 2000..Neurotrophins are important regulators during the development of the visual system as well as potential therapeutic agents in degenerative retinal disease and after optic nerve injury. ..
- CNS NORADRENERGIC NEURONS--TROPHIC FACTORSANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 1999....
- AMELIORATION OF FETAL ALCOHOL EFFECTSJOHN HANNIGAN; Fiscal Year: 2004..The results could have direct implications for the development of effective and appropriate treatments for FAS/ARNDs in children. ..
- A Protein-Polymer Approach to Neural Tissue RegenerationKim Janda; Fiscal Year: 2005..We envisage that the initial studies described herein will serve as the foundation for further studies in our laboratory in the design and chemical synthesis of biomimetic tissue regeneration matrices. ..
- Role of sphingosine-1-phosphate in oligodendrocytesHARSIMRAN SAINI; Fiscal Year: 2005..A better understanding of the signaling pathways involved in OLG development will offer new avenues for the treatment of demyelinating conditions such as multiple sclerosis ..
- NEUROTROPHIN CONTROL OF REM SLEEPJack Yamuy; Fiscal Year: 2004..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
- Regulatory Molecules in Enteric Nervous SystemALCMENE CHALAZONITIS; Fiscal Year: 2006....
- MECHANISMS OF SYMPATHETIC NEURON SPECIFICATIONMaya Sieber Blum; Fiscal Year: 2004..Both types of drug easily cross the placenta and can cause autonomic disturbances in infants born to mothers who have been treated with the antidepressant, or who have used cocaine during pregnancy. ..
- Behavior of Stem Cells in the Lesioned Aging HippocampusAshok Shetty; Fiscal Year: 2006..abstract_text> ..
- Repair of Chronially Injured Hippocampus by GraftsAshok Shetty; Fiscal Year: 2006..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
- Replacing an Animal Resource Facility Cage Washer.Kristen Drescher; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
- STEM CELL FACTOR ACTION IN NEURAL CREST DEVELOPMENTMaya Sieber Blum; Fiscal Year: 2003..However, the newly detected additional roles of SCF in maintaining stem cells, up-regulating neurotrophin receptors and promoting sensory neurogenesis suggest additional defects in human piebaldism that remain to be elucidated. ..
- IMPROVED CELL COUNTING USING THE OPTICAL DISECTORCHRISTOPHER VON BARTHELD; Fiscal Year: 2004....
- INVERSE METASTATIC MODALITIES BY HEPARANASESDario Marchetti; Fiscal Year: 2005..They will provide a framework for the development of polysaccharide-based anti-cancer molecules as important prognostic tools and diagnostic screens for metastatic detection, diagnosis and treatment. ..
- Genetic remodeling of Vagal Afferent OrganizationEdward Fox; Fiscal Year: 2009..Moreover, it will form an essential foundation for further research on the development of, and the structural and functional organization of, the diverse systems that form the vagal sensorium. ..
- Novel Ex Vivo Gene Therapy for Spinal Cord InjuryAlpa Trivedi; Fiscal Year: 2004..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
- BEHAVIORALLY INDUCED NEUROCHEMICAL PLASTICITYChristine Gall; Fiscal Year: 2001..The proposed work will provide a first test for their presence in regions engaged learning behaviors. ..
- Eph/ephrin Signaling in Taste Nerve DevelopmentMICHAEL ROCHLIN; Fiscal Year: 2006..We will place beads soaked in diffusible (Fc) constructs of these molecules near the ganglion to test their impact on nerve divergence. [unreadable] [unreadable] [unreadable]..
- Calcitriol and Methamphetamine NeurotoxicityWayne Cass; Fiscal Year: 2008..Furthermore, if calcitriol is effective, it could have therapeutic applications in other disease processes where there is a loss of monoamine neurons, such as in Parkinson's disease. [unreadable] [unreadable] [unreadable]..
- A Novel Gene Network Controlling Mammalian PubertySergio Ojeda; Fiscal Year: 2006..Although siRNAs are widely used to perturb gene expression in mammalian cells, the methodology to achieve long-term silencing effects in vivo is still in its infancy. [unreadable] [unreadable]..