nerve growth factor

Summary

Summary: NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.

Top Publications

  1. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
  2. ncbi Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment epithelial cells
    Guo Fan Cao
    The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 414:499-505. 2011
  3. ncbi JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis
    Girish V Putcha
    Department of Neurology and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 38:899-914. 2003
  4. ncbi Signaling pathways for PC12 cell differentiation: making the right connections
    D Vaudry
    Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA
    Science 296:1648-9. 2002
  5. pmc NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    Xuming Zhang
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    EMBO J 24:4211-23. 2005
  6. pmc Nerve growth factor promotes cardiac repair following myocardial infarction
    Marco Meloni
    Experimental Cardiovascular Medicine Division, Bristol Heart Institute, Bristol, United Kingdom
    Circ Res 106:1275-84. 2010
  7. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
  8. pmc Nerve growth factor links oral cancer progression, pain, and cachexia
    Yi Ye
    Bluestone Center for Clinical Research, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010, USA
    Mol Cancer Ther 10:1667-76. 2011
  9. ncbi Sortilin is essential for proNGF-induced neuronal cell death
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    Nature 427:843-8. 2004
  10. ncbi A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling
    Rejji Kuruvilla
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 118:243-55. 2004

Detail Information

Publications320 found, 100 shown here

  1. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    ..Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly ..
  2. ncbi Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment epithelial cells
    Guo Fan Cao
    The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 414:499-505. 2011
    ..Oxidative stress plays an important role in this progress. Nerve growth factor (NGF) is important for the survival and maintenance of sympathetic and sensory neurons and NGF eye drops ..
  3. ncbi JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis
    Girish V Putcha
    Department of Neurology and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 38:899-914. 2003
    ..Thus, JNKs regulate the proapoptotic activity of BIM(EL) during TFD, both transcriptionally and posttranslationally...
  4. ncbi Signaling pathways for PC12 cell differentiation: making the right connections
    D Vaudry
    Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA
    Science 296:1648-9. 2002
    ..Two growth hormones, epidermal growth factor (EGF) and nerve growth factor (NGF), use the same pathway to cause PC12 proliferation and differentiation, respectively...
  5. pmc NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    Xuming Zhang
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    EMBO J 24:4211-23. 2005
    ..Phosphorylation of TRPV1 at a single tyrosine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most of the rapid sensitizing actions of NGF...
  6. pmc Nerve growth factor promotes cardiac repair following myocardial infarction
    Marco Meloni
    Experimental Cardiovascular Medicine Division, Bristol Heart Institute, Bristol, United Kingdom
    Circ Res 106:1275-84. 2010
    b>Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival, which are both desirable for postinfarction myocardial healing. Nonetheless, the NGF potential for cardiac repair has never been investigated.
  7. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    ....
  8. pmc Nerve growth factor links oral cancer progression, pain, and cachexia
    Yi Ye
    Bluestone Center for Clinical Research, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010, USA
    Mol Cancer Ther 10:1667-76. 2011
    ..Because nerve growth factor (NGF) plays a cardinal role in inflammation and pain, and because it interacts with multiple ..
  9. ncbi Sortilin is essential for proNGF-induced neuronal cell death
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    Nature 427:843-8. 2004
    ..Sortilin is expressed during embryogenesis in areas where nerve growth factor (NGF) and its precursor, proNGF, have well-characterized effects...
  10. ncbi A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling
    Rejji Kuruvilla
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 118:243-55. 2004
    ....
  11. ncbi Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha
    Klaus F Wagner
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Respir Cell Mol Biol 31:276-82. 2004
    ..These results indicate a role for HIMF in lung development, possibly under the control of HIF-2, and suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation...
  12. ncbi Nerve growth factor signaling, neuroprotection, and neural repair
    M V Sofroniew
    Department of Neurobiology and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    Annu Rev Neurosci 24:1217-81. 2001
    b>Nerve growth factor (NGF) was discovered 50 years ago as a molecule that promoted the survival and differentiation of sensory and sympathetic neurons...
  13. ncbi Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 TD, United Kingdom
    J Neurosci 21:8722-33. 2001
    ..The nerve growth factor (NGF) dependence of the inflammation-induced changes was examined by injecting a synthetic NGF sequestering ..
  14. ncbi Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
    J Whitfield
    Eisai London Research Laboratories, Bernard Katz Building, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 29:629-43. 2001
    Sympathetic neurons require nerve growth factor for survival and die by apoptosis in its absence. Key steps in the death pathway include c-Jun activation, mitochondrial cytochrome c release, and caspase activation...
  15. pmc Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses
    Maria Ascano
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 29:11674-85. 2009
    ..Anterograde TrkA delivery and exocytosis into axon growth cones is enhanced by nerve growth factor (NGF), acting locally on distal axons...
  16. pmc Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf
    Kartik Sunagar
    CIMAR CIIMAR, Centro Interdisciplinar de Investigacao Marinha e Ambiental, Universidade do Porto, Porto, Portugal Departamento de Biologia, Faculdade de Ciencias, Universidade do Porto, Porto, Portugal
    PLoS ONE 8:e81827. 2013
    ....
  17. pmc Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice
    Simona Capsoni
    European Brain Research Institute, Rome, Italy
    PLoS ONE 7:e37555. 2012
    b>Nerve Growth Factor (NGF) is being considered as a therapeutic candidate for Alzheimer's disease (AD) treatment but the clinical application is hindered by its potent pro-nociceptive activity...
  18. ncbi A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model
    S Capsoni
    Scuola Normale Superiore, Pisa, Italy
    CNS Neurol Disord Drug Targets 10:635-47. 2011
    The neurotrophin Nerve Growth Factor (NGF) is essential for the maintenance and differentiation of basal forebrain cholinergic neurons...
  19. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    The cardiac sympathetic nerve plays an important role in regulating cardiac function, and nerve growth factor (NGF) contributes to its development and maintenance...
  20. ncbi Nerve growth factor and tyrosine kinase A receptor in oral squamous cell carcinoma: is there an association with perineural invasion?
    Antonia Kolokythas
    Department of Oral and Maxillofacial Surgery, University of Illinois at Chicago College of Dentistry, Chicago, IL, USA
    J Oral Maxillofac Surg 68:1290-5. 2010
    ..PNI is associated with locoregional recurrence and decreased survival of patients with head and neck SCC. Nerve growth factor (NGF) has been shown to be involved in PNI in several malignancies, including breast, prostate, and ..
  21. ncbi Identification of new Nerve Growth Factor-responsive immediate-early genes
    T F Dijkmans
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, PO Box 9502, 2300 RA, Leiden, The Netherlands
    Brain Res 1249:19-33. 2009
    Stimulation of the PC12 pheochromocytoma cell line with the prototypical neurotrophin Nerve Growth Factor (NGF) induces a cellular response of neuronal differentiation and is therefore a widely used model to gain molecular insight into ..
  22. ncbi Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells
    Hyun Kim
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 279:33538-46. 2004
    ..These endothelial cells also express p75NTR and respond to its preferred ligand, pro-nerve growth factor (pro-NGF), by undergoing apoptosis...
  23. pmc CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells
    Jianbo Yue
    Department of Physiology, The University of Hong Kong, Hong Kong
    J Biol Chem 284:29335-42. 2009
    ..Inhibition of the pathway, on the other hand, accelerated nerve growth factor (NGF)-induced neuronal differentiation in PC12 cells...
  24. ncbi Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures
    Kaberi P Das
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 26:397-406. 2004
    ..PC12 cells, which differentiate upon nerve growth factor (NGF) stimulation, were used as the in vitro model...
  25. ncbi Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiología Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 89:464-73. 2004
    ..in the ventral spinal cord of transgenic ALS-mutant G93A superoxide dismutase (SOD) mice expressed nerve growth factor (NGF) in regions where degenerating motor neurons expressed p75 neurotrophin receptor (p75(NTR)) and were ..
  26. ncbi The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
    Soline Estrach
    CRBM CNRS, UPR 1086 CNRS, 1919 Route de Mende, 34293 5, Montpellier Cedex, France
    Curr Biol 12:307-12. 2002
    ..outgrowth is mediated by the GEFD1-dependent activation of RhoG, previously shown to be part of the NGF (nerve growth factor) pathway...
  27. ncbi Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain
    Masamichi Shinoda
    Department of Physiology, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Neurosci 31:7145-55. 2011
    ..Here, we investigated the functional significance of interaction of nerve growth factor (NGF) and transient receptor potential vanilloid 1 (TRPV1) in relation to heat hyperalgesia in the whisker ..
  28. pmc NGF-promoted axon growth and target innervation requires GITRL-GITR signaling
    Gerard W O'Keeffe
    School of Biosciences, Biomedical Building, Museum Avenue, Cardiff, CF10 3US, UK
    Nat Neurosci 11:135-42. 2008
    b>Nerve growth factor (NGF) has an important role in regulating sympathetic neuron survival and target field innervation during development...
  29. ncbi Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration
    Takayuki Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502
    J Neurosci 22:9228-36. 2002
    ..microglia invade the degenerating photoreceptor layer and alter expression of neurotrophic factors such as nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), and glial cell line-derived neurotrophic factor (GDNF)...
  30. pmc Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival
    Anthony W Harrington
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 146:421-34. 2011
    ..Differential control of this process explains how NGF but not NT3 supports retrograde survival of sympathetic neurons...
  31. ncbi Ionically cross-linked chitosan microspheres for controlled release of bioactive nerve growth factor
    Wen Zeng
    Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Chang le Road No 145, Xi an 710032, Shaanxi, China
    Int J Pharm 421:283-90. 2011
    ..The present study aims to investigate the feasibility of the controlled release of bioactive nerve growth factor (NGF) with ionically cross-linked chitosan microspheres (NGF-CMSs)...
  32. ncbi NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals
    Jean Dominique Delcroix
    Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
    Neuron 39:69-84. 2003
    ..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies...
  33. ncbi Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder
    Shiu Dong Chung
    Department of Urology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Neurourol Urodyn 30:417-20. 2011
    ..An elevation of C-reactive protein (CRP) has been associated with chronic inflammation and lower urinary tract symptoms. This study aims to elucidate the association between CRP and OAB or IC/BPS...
  34. pmc Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors
    Raheleh Masoudi
    Department of Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 284:18424-33. 2009
    b>Nerve growth factor (NGF) is produced as a precursor called pro-nerve growth factor (proNGF), which is secreted by many tissues and is the predominant form of NGF in the central nervous system...
  35. ncbi Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice
    Simona Capsoni
    Lay Line Genomics S p A, Rome, Italy
    J Alzheimers Dis 16:371-88. 2009
    b>Nerve growth factor (NGF) has a great potential for the treatment of Alzheimer's disease...
  36. pmc Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ
    Y H Zhang
    Dept of Pharmacology and Toxicology, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    J Neurophysiol 107:315-35. 2012
    Our previous work showed that nerve growth factor (NGF) increased the excitability of small-diameter capsaicin-sensitive sensory neurons by activating the p75 neurotrophin receptor and releasing sphingolipid-derived second messengers...
  37. pmc NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection
    Sreekumar Othumpangat
    Department of Pediatrics and Pediatric Research Institute, West Virginia University School of Medicine, Morgantown, West Virginia, United States of America
    PLoS ONE 4:e6444. 2009
    ....
  38. ncbi Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems
    Marco Fiore
    Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy
    Rev Neurosci 20:133-45. 2009
    b>Nerve growth factor (NGF) is a signaling molecule, originally discovered for its role on differentiation and survival of peripheral sensory and sympathetic neurons...
  39. ncbi Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells
    Jinyoung Hur
    Graduate School of East West Medical Science, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 27:1257-60. 2004
    ..astrocyte induced the neurite outgrowth of PC12 cells, and that the effect was reversed by addition of nerve growth factor (NGF)-antibody and GF109203X, an inhibitor of protein kinase (PKC)...
  40. pmc Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth
    Shahrzad Shirazi Fard
    Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 5:e9647. 2010
    b>Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases...
  41. ncbi 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
    Jillanne Brown
    School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Neurosci Lett 343:139-43. 2003
    ..The receptor for this seco-steroid is expressed in both neurons and glial cells, it induces nerve growth factor (NGF) and it is a potent inhibitor of mitosis and promoter of differentiation in numerous cells...
  42. ncbi The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 89:581-92. 2004
    b>Nerve growth factor (NGF) promotes neuronal survival and differentiation and stimulates neurite outgrowth. NGF is synthesized as a precursor, proNGF, which undergoes post-translational processing to generate mature beta-NGF...
  43. ncbi Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor
    Qing Xue
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0427, USA
    J Neurochem 101:212-22. 2007
    ..Although both promoter regions directed transcriptional activity in nerve growth factor (NGF) treated rat sensory neurons, the upstream Core promoter was the most active in cultures enriched in ..
  44. pmc Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
    Alexander T Stein
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 128:509-22. 2006
    ..of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by proalgesic agents such as nerve growth factor (NGF)...
  45. ncbi Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
    Grant D Nicol
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Interv 7:26-41. 2007
    b>Nerve Growth Factor (NGF) is produced by and affects a number of immune and inflammatory cells...
  46. pmc NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes
    Jonah R Chan
    Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building D235, CA 94305, USA
    Neuron 43:183-91. 2004
    ..Here we identify the neurotrophin nerve growth factor (NGF) as a potent regulator of the axonal signals that control myelination of TrkA-expressing dorsal root ..
  47. ncbi Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs
    Shengmei Zhou
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, USA
    Circ Res 95:76-83. 2004
    ..However, the mechanisms responsible for nerve sprouting after MI are unclear. The expression of nerve growth factor (NGF), growth associated protein 43 (GAP43), and other nerve markers were studied at the infarcted site, ..
  48. ncbi Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
    Karun K Singh
    Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8
    Nat Neurosci 11:649-58. 2008
    ..These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration...
  49. ncbi A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
    Cholinergic neuron loss is a cardinal feature of Alzheimer disease. Nerve growth factor (NGF) stimulates cholinergic function, improves memory and prevents cholinergic degeneration in animal models of injury, amyloid overexpression and ..
  50. ncbi Heterogeneous requirement of NGF for sympathetic target innervation in vivo
    Natalia O Glebova
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:743-51. 2004
    The neurotrophin nerve growth factor (NGF) plays a crucial role in the development of the sympathetic nervous system...
  51. pmc APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction
    Dan C Lin
    Cancer Research Program, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Ontario, Canada
    Mol Cell Biol 26:8928-41. 2006
    ..Reduction of APPL1 or GIPC1 protein levels suppressed nerve growth factor (NGF)-dependent MEK, extracellular signal-regulated kinase, and Akt activation and neurite outgrowth in ..
  52. pmc Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis
    David A Walsh
    Arthritis Research UK Pain Centre, Division of Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, UK
    Rheumatology (Oxford) 49:1852-61. 2010
    ..CD3 (lymphocytes), proliferating cell nuclear antigen, vascular endothelial, platelet-derived and nerve growth factor (NGF). Results...
  53. ncbi An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    C D Pozniak
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    Science 289:304-6. 2000
    ..as a truncated isoform whose levels are dramatically decreased when sympathetic neurons apoptose after nerve growth factor (NGF) withdrawal...
  54. ncbi Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors
    Tom Wehrman
    Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, The Stem Cell Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 53:25-38. 2007
    b>Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a "high-affinity" NGF binding site through formation of a ternary TrkA/NGF/p75 complex...
  55. ncbi Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis
    G V Putcha
    Departments of Neurology and Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 29:615-28. 2001
    Sympathetic neuronal death induced by nerve growth factor (NGF) deprivation requires the macromolecular synthesis-dependent translocation of BAX from the cytosol to mitochondria and its subsequent integration into the mitochondrial outer ..
  56. pmc Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
    Jennifer K Bonnington
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 551:433-46. 2003
    b>Nerve growth factor (NGF) causes a rapid sensitisation of nociceptive sensory neurones to painful thermal stimuli owing to an action on the heat and capsaicin receptor TRPV1 (formerly known as VR1)...
  57. pmc Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration
    Simona Capsoni
    European Brain Research Institute, 00143 Rome, Italy
    Proc Natl Acad Sci U S A 107:12299-304. 2010
    ..Thus, we demonstrate that inhibiting TrkA signaling activates Abeta accumulation and that different streams of AD neurodegeneration are related in complex ways to TrkA versus p75NTR signaling...
  58. ncbi Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo
    Giuseppina Cantarella
    Department of Experimental and Clinical Pharmacology, University of Catania School of Medicine, I 95125 Catania, Italy
    FASEB J 16:1307-9. 2002
    b>Nerve growth factor (NGF) has important functions during embryonic development and on various tissues and organs under normal and pathological conditions during the extrauterine life...
  59. pmc APP is phosphorylated by TrkA and regulates NGF/TrkA signaling
    Carmela Matrone
    Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, 00143 Rome, Italy
    J Neurosci 31:11756-61. 2011
    ..This evidence suggests that these two membrane protein's functions are strictly interconnected and that the NGF/TrkA signaling pathway is involved in AD pathogenesis and can be used as a therapeutic target...
  60. ncbi Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
    T D Patel
    University of North Carolina Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA
    Neuron 25:345-57. 2000
    ..in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA...
  61. ncbi Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    J Mol Neurosci 40:230-5. 2010
    Basal forebrain cholinergic neurons are highly dependent on nerve growth factor (NGF) supply for the maintenance of their cholinergic phenotype as well as their cholinergic synaptic integrity...
  62. ncbi ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
    T Harada
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
    Nat Cell Biol 3:453-9. 2001
    ..Our results thus define an essential signalling pathway, downstream of ERK/MAPK, that leads to neuronal differentiation...
  63. ncbi Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain
    Antonino Cattaneo
    European Brain Research Institute, Roma, Italy
    Curr Opin Mol Ther 12:94-106. 2010
    ..b>Nerve growth factor (NGF) is involved in pain transduction mechanisms, playing a key role as a master switch in many chronic ..
  64. ncbi NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway
    C L Howe
    Department of Neurology, Stanford University Medical Center, 1201 Welch Road, MSLS P211, Stanford, CA 94305, USA
    Neuron 32:801-14. 2001
    The target-derived neurotrophic factor "nerve growth factor" (NGF) signals through TrkA to promote the survival, differentiation, and maintenance of neurons. How the NGF signal in axon terminals is conveyed to the cell body is unknown...
  65. ncbi Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder
    Hsin Tzu Liu
    Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    BJU Int 103:1668-72. 2009
    To determine urinary nerve growth factor (NGF) levels in patients with overactive bladder (OAB) and after treatment with antimuscarinics.
  66. pmc Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
    N G Seidah
    J A DeSève Laboratories of Biochemical and Molecular Neuroendocrinology, Clinical Research Institute of Montreal, University of Montreal, Canada
    Biochem J 314:951-60. 1996
    In order to define the enzymes responsible for the maturation of the precursor of nerve growth factor (proNGF), its biosynthesis and intracellular processing by the pro-protein convertases furin, PC1, PC2, PACE4, PC5 and the PC5 isoform ..
  67. ncbi Caveolin-1 inhibits TrkA-induced cell death by influencing on TrkA modification associated with tyrosine-490 phosphorylation
    Eun Joo Jung
    Department of Biochemistry, Gyeongsang National University, School of Medicine, Jinju, South Korea
    Biochem Biophys Res Commun 402:736-41. 2010
    ..Our results suggest that caveolin-1 could suppress TrkA-mediated pleiotypic effects by altering TrkA modification via functional interaction...
  68. ncbi Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins
    I Ivankovic-Dikic
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S 75124, Sweden
    Nat Cell Biol 2:574-81. 2000
    ..Thus, Pyk2/FAK have important functions in signal integration proximal to integrin/growth-factor receptor complexes in neurons...
  69. pmc Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease
    Hsin Tzu Liu
    Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualin, Taiwan
    PLoS ONE 7:e44687. 2012
    Interstitial cystitis/bladder pain syndrome (IC/BPS) is considered a bladder disorder due to localized chronic inflammation. This study investigated the nerve growth factor (NGF) levels in serum and urine in patients with IC/BPS.
  70. ncbi Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3
    Seong Ho Koh
    Department of General Toxicology, National Institute of Toxicological Research, KFDA, Seoul, South Korea
    Brain Res Mol Brain Res 118:72-81. 2003
    ..oxidative-stress-induced injury were studied using H2O2-treated PC12 cells, which were differentiated by nerve growth factor (NGF)...
  71. ncbi Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice
    G Graiani
    Department of Pathology, University of Parma, Italy
    Diabetologia 47:1047-54. 2004
    The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair...
  72. pmc Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein
    Yohann Demont
    INSERM U908 Growth Factor Signaling in Breast Cancer, University of Lille, Villeneuve d Ascq 59655, France
    J Biol Chem 287:1923-31. 2012
    The precursor of nerve growth factor (proNGF) has been described as a biologically active polypeptide able to induce apoptosis in neuronal cells, via the neurotrophin receptor p75(NTR) and the sortilin receptor...
  73. pmc Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats
    Wohaib Hasan
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas 66160, USA
    Brain Res 1124:142-54. 2006
    ..Aberrant sympathetic sprouting is associated with elevated nerve growth factor (NGF) in many contexts, including ventricular hyperinnervation...
  74. ncbi Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities
    Gry Houeland
    Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, 00143 Rome, Italy
    J Neurosci 30:13089-94. 2010
    ..states that AD-related loss of cholinergic signaling and altered APP processing are due to alterations in nerve growth factor (NGF) trophic support...
  75. pmc ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex
    Mary Louise Rogers
    Department of Human Physiology, School of Medicine, Flinders University, GPO Box 2100 Adelaide 5001, Australia
    J Neuroimmunol 226:93-103. 2010
    ..This was reduced by blocking sortilin with neurotensin. We conclude that proNGF induced apoptosis of NK cells may have important implications for limiting the innate immune response...
  76. ncbi Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy
    Kensuke Kimura
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Circ Res 100:1755-64. 2007
    ..growth factors such as endothelin-1, angiotensin II, and leukemia inhibitory factor, little is known about nerve growth factor expression and its effect on the cardiac sympathetic nerves...
  77. pmc The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    Mol Biol Cell 17:607-22. 2006
    ..PIPP therefore inhibits PI3-kinase-dependent neurite elongation in PC12 cells, via regulation of the spatial distribution of phospho-Ser473-Akt and phospho-Ser9-GSK-3beta signaling...
  78. ncbi Cardiac NGF and GDNF expression during Trypanosoma cruzi infection in rats
    Patrícia Massara Martinelli
    Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901, Belo Horizonte, MG, Brazil
    Auton Neurosci 130:32-40. 2006
    ..The present work shows the cardiac levels of glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF), and their cellular sources during T. cruzi infection in rats...
  79. ncbi Cistanches Herba enhances learning and memory by inducing nerve growth factor
    Jin Gyu Choi
    Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East West Pharmaceutical Research Institute, Kyung Hee University, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    Behav Brain Res 216:652-8. 2011
    b>Nerve growth factor (NGF) has potent biological activities such as preventing neuronal death, promoting neurite outgrowth, supporting synapse formation, and enhancing memory function...
  80. pmc Effect of cavtratin, a caveolin-1 scaffolding domain peptide, on oligodendroglial signaling cascades
    Matthias Schmitz
    Max Planck Institute of Experimental Medicine, RU Neural Regeneration, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Cell Mol Neurobiol 31:991-7. 2011
    ..Previous reports of our lab indicated a co-localization of caveolin and the high affinity nerve growth factor (NGF) receptor tyrosine kinase A (TrkA)...
  81. ncbi Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells
    Y Sakai
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan
    Biochem Biophys Res Commun 285:656-61. 2001
    ....
  82. pmc Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons
    Sharon J Yu
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Mol Pain 8:48. 2012
    ..The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated...
  83. ncbi Blockage of nerve growth factor modulates T cell responses and inhibits allergic inflammation in a mouse model of asthma
    Yan Shi
    Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 130021 Changchun, China
    Inflamm Res 61:1369-78. 2012
    Blockage of nerve growth factor (NGF) by anti-NGF antibodies can inhibit allergic airway hyper-responsiveness in mice. This study was aimed at determining the mechanisms underlying the action of anti-NGF in vivo.
  84. pmc Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor
    Sandra M Morillo
    Department of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Proc Natl Acad Sci U S A 107:109-14. 2010
    ..Thus, a developmental program leading to somatic tetraploidy in specific retinal neurons exists in vertebrates. This program might occur in other vertebrate neurons during normal or pathological situations...
  85. pmc Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways
    Rodrigue Romon
    INSERM U908, F 59650 Villeneuve d Ascq, France
    Mol Cancer 9:157. 2010
    ..The objective of the present study was to determine the involvement of nerve growth factor (NGF) in breast cancer angiogenesis and the underlying molecular mechanisms.
  86. ncbi Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor
    J V Priestley
    Department of Neuroscience, Bart and The London, School of Medicine and Dentistry, Queen Mary University of London, England
    Can J Physiol Pharmacol 80:495-505. 2002
    ..can be regulated by glial cell line derived neurotrophic factor (GDNF) and those in populations 2 and 3 by nerve growth factor (NGF)...
  87. pmc The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome
    Wen Wu Li
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Pain 144:303-13. 2009
    ..Our data also highlight the importance of the keratinocyte as the primary source of post-traumatic IL-1beta over-expression...
  88. pmc Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 29:14790-802. 2009
    ..Together, these results raise the intriguing possibility that dysregulation of proneurotrophin processing/release by innervated targets can be deleterious to the neurons projecting to these sites...
  89. ncbi Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats
    L Manni
    Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy
    Diabetologia 54:1900-8. 2011
    Diabetes is considered the leading cause of neuropathies in developed countries. Dysfunction of nerve growth factor (NGF) production and/or utilisation may lead to the establishment of diabetic neuropathies...
  90. pmc p190RhoGAP and Rap-dependent RhoGAP (ARAP3) inactivate RhoA in response to nerve growth factor leading to neurite outgrowth from PC12 cells
    Chan Young Jeon
    Department of Biochemistry, Hallym University College of Medicine, Chuncheon 200 702, Korea
    Exp Mol Med 42:335-44. 2010
    Rat pheochromocytoma (PC12) cells have been used to investigate neurite outgrowth. Nerve growth factor (NGF) has been well known to induce neurite outgrowth from PC12 cells...
  91. ncbi Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy
    R A Kirkland
    Department of Neurological Surgery, University of Wisconsin Medical School, 4640 MSC, 1300 University Avenue, Madison 53706, USA
    Neuroscience 115:587-602. 2002
    ..Here we show that the cardiolipin content of nerve growth factor (NGF)-deprived rat sympathetic neurons undergoing apoptotic death in cell culture decreased before ..
  92. ncbi Cooperative modulation of neuritogenesis by PC12 cells by topography and nerve growth factor
    John D Foley
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Biomaterials 26:3639-44. 2005
    ..To test this, we cultured PC12 cells with a range of nerve growth factor (NGF) concentrations on surfaces with ridge widths ranging from 70 to 1900 nm...
  93. pmc MicroRNA-221 modulates RSV replication in human bronchial epithelium by targeting NGF expression
    Sreekumar Othumpangat
    Department of Pediatrics and Pediatric Research Institute, West Virginia University School of Medicine, Morgantown, West Virginia, United States of America
    PLoS ONE 7:e30030. 2012
    ..respiratory syncytial virus (RSV) is associated with aberrant expression of the prototypical neurotrophin nerve growth factor (NGF) and its cognate receptors in human bronchial epithelium...
  94. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..Local DRG perfusion with TTX also reduced levels of nerve growth factor (NGF) in the SNL model on day 3 (when activated glia are an important source of NGF), without affecting the ..
  95. pmc p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation
    Joe P S Makkerh
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada
    EMBO Rep 6:936-41. 2005
    ..Coexpression of p75 NTR attenuated ubiquitination of TrkA and TrkB and delayed nerve growth factor-induced TrkA receptor internalization and receptor degradation...
  96. ncbi The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..Here, we report that p62 functions to facilitate K63-polyubiquitination of TRAF6 and thereby mediates nerve growth factor-induced activation of the NF-kappaB pathway...
  97. ncbi Gender-dependent association of a functional NGF polymorphism with anxiety-related personality traits
    U E Lang
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 41:196-9. 2008
    b>Nerve growth factor (NGF) has been shown to be involved in anxiety behaviour and the expression of conditioned fear in mice.
  98. ncbi Nerve growth factor and wound healing
    Keiko Kawamoto
    Laboratory of Clinical Immunology, Department of Veterinary Clinic, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Prog Brain Res 146:369-84. 2004
    ..Besides many biological activities on both neuronal and nonneuronal cells, nerve growth factor (NGF) has been proposed as an important component of wound healing and tissue repair process in vivo and in ..
  99. pmc Nerve growth factor gene therapy using adeno-associated viral vectors prevents cardiomyopathy in type 1 diabetic mice
    Marco Meloni
    Laboratory of Vascular Pathology and Regeneration, Regenerative Medicine Section, School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 61:229-40. 2012
    Diabetes is a cause of cardiac dysfunction, reduced myocardial perfusion, and ultimately heart failure. Nerve growth factor (NGF) exerts protective effects on the cardiovascular system...
  100. ncbi Developmental Vitamin D3 deficiency alters the adult rat brain
    F Feron
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
    Brain Res Bull 65:141-8. 2005
    ..Brains from these animals also had reduced expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor...
  101. pmc Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell dif
    Steven Mullenbrock
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:45131-45. 2011
    ..Interestingly, Fra1 as well as two other NGF-induced AP-1 targets (HB-EGF and miR-21) function in positive feedback loops that may contribute to sustained AP-1 activity...

Research Grants72

  1. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..The main objective of this study is to provide the direct and indirect evidences for the role of nerve growth factor (NGF) and its receptor system (NGF-R) in the pathogenesis of psoriasis and psoriatic arthritis (PsA)...
  2. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..The therapeutic benefits of nitro-fatty acids (FA-NO2) and brain-derived neurotrophic factor- and nerve growth factor-antibodies (BDNF-AB and NGF-AB) will be tested...
  3. Growth Hormone Regulation of SH2B1
    Christin Carter-Su; Fiscal Year: 2013
    ..g., leptin, insulin, nerve growth factor) that utilize SH2B1 as a signaling protein...
  4. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..IFN? also induces the expression of nerve growth factor (NGF) and has pronounced anti-inflammatory effects...
  5. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..b>Nerve Growth Factor (NGF) was discovered by Rita Levi-Montalcini and Stanley Cohen in the late 1950's...
  6. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..One type of cell involved in the repair of airway epithelium is the basal cell. The low-affinity nerve growth factor receptor (NGFR) has been identified as a marker for basal cells, as well as for epithelial stem cells in ..
  7. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..will test hypotheses regarding the roles of adrenal and gonadal signaling pathways regulating brain-derived nerve growth factor (BDNF;associated with MOD) and its interactions with gamma aminobutyric acid (GABA)-ergic, glutamate (GLU)-..
  8. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
    ..techniques to examine densities of cell type-specific antibodies directed at the proliferating low-affinity nerve growth factor receptor (p75NGFR), postmitotic immature neurons (growth- associated protein 43 [GAP43]), and olfactory ..
  9. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ..of NTF and NTF receptors and measure serum levels of three NTF: brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) in the large, middle-aged to elderly, community-based, ..
  10. Induction of Nerve Growth Factor by Nicotine Leads to Airway Dysfunction
    CHERRY P WONGTRAKOOL; Fiscal Year: 2013
    ..In this proposal, we hypothesize that chronic nicotine exposure promotes AHR by inducing nerve growth factor (NGF) secretion in lung fibroblasts through 17 nAChR dependent signaling...
  11. Growth Hormone Regulation of SH2-B1
    Christin Carter Su; Fiscal Year: 2009
    ..g. leptin, insulin, nerve growth factor) that also utilize SH2B1 as a signaling protein...
  12. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ..of keratinocyte inflammasomes is required for the production of IL-12, downstream mediators such as nerve growth factor (NGF), and ultimately the development of CRPS-like features in our rodent model...
  13. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    ..In the current proposal, we propose to use this approach for silencing nerve growth factor (NGF) gene locally in the bladder...
  14. Varicella-zoster Virus: Tegument Proteins in Pathogenesis
    Ann Arvin; Fiscal Year: 2012
    ..infected DRG will examine heat, chemical agents, histone deacetylase inhibitors, interference with nerve growth factor signaling and other triggers known to enhance herpes simplex virus reactivation. The work proposed for Yr...
  15. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..kinase (cPLA2/ERK1/2) signaling to release DHA for the synthesis of NPD1, which stimulates nerve growth factor (NGF) expression that, in turn, modulates corneal nerve regeneration...
  16. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..how are two receptors sorted from one another into specific signaling endosomes? The two receptors for nerve growth factor (NGF), TrkA and p75NTR, are rapidly sorted upon ligand binding to distinct endosomes...
  17. Neurotrophins and Post-infarct Plasicity in Cardiac Sympathetic Neurons
    Beth A Habecker; Fiscal Year: 2013
    ..The neurotrophins Nerve Growth Factor (NGF) and Brain Derived-Neurotrophic Factor (BDNF) are elevated in heart following infarction...
  18. NGF Receptor Regulates Prostate Growth
    Daniel Djakiew; Fiscal Year: 2009
    ..One such receptor is the p75NTR, a cell surface protein that binds the neurotrophins (e.g. nerve growth factor)...
  19. Exogenous growth factors for reversal of age-related laryngeal muscle denervation
    Joseph Stemple; Fiscal Year: 2011
    ..Specific Aim I will examine whether systemic administration of the exogenous neurotrophins brain-derived nerve growth factor (BDNF) and neurotrophin-4 (NT-4) changes determinants of NMJ assembly in the aging PCA and TA...
  20. Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem Cells
    Jeffrey L Spees; Fiscal Year: 2012
    ..conditioned by mixed MSCs or by standardized MSCs isolated by magnetic sorting for the p75 low affinity nerve growth factor receptor (p75LNGFR;p75MSCs) can support the growth and survival of adult cardiac stem/progenitor cells ..
  21. Cystitis-Induced Plasticity of Micturitin Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2013
    ..in visceral sensation may be mediated, in part, by inflammatory changes in the urinary bladder including nerve growth factor (NGF)...
  22. Survival and growth-promotion mechanisms of the GDNF family ligands (GFLs)
    BRIAN ANTHONY PIERCHALA; Fiscal Year: 2012
    ..b>Nerve growth factor (NGF), a member of the neurotrophin family of growth factors, regulates the trophic status of sympathetic ..
  23. Perinatal choline therapy in a mouse model of Down Syndrome &Alzheimer's Disease
    Barbara J Strupp; Fiscal Year: 2012
    ..the hypothesis that improved cognitive functioning in Ts65Dn and 2N mice is mediated by alterations in the nerve growth factor (NGF) family of neurotrophins and its cognate receptors in CBF target regions (frontal cortex and ..
  24. Bioengineered scaffolds for peripheral nerve repair
    Ravi V Bellamkonda; Fiscal Year: 2010
    ..3D hydrogel based scaffolds with either isotropically or anisotropically distributed ECM (laminin-1) or nerve growth factor (NGF) to bridge gaps longer than 15mm in rats...
  25. Molecular mechanisms of perineural invasion in pancreatic cancer
    Haiyong Han; Fiscal Year: 2010
    ..Recent reports indicate that expression of nerve growth factor (NGF) and its receptors correlate with perineural invasion and pain in human pancreatic cancer...
  26. Intracellular Target of Sphingosine-1-Phosphate
    GRAHAM M STRUB; Fiscal Year: 2010
    ..of SIP in neurons by sphingosine kinases (SphKs) is stimulated by a variety of agonists, including nerve growth factor (NGF) and neurotrophin-3 (NT- 3), and many of its functions are mediated by its cell surface receptors (..
  27. Small RNA regulation of BDNF expression in schizophrenia
    Schahram Akbarian; Fiscal Year: 2012
    ..We will study a subset of microRNAs that might regulate a nerve growth factor protein, in postmortem brain of subjects diagnosed with schizophrenia and controls, these studies might ..
  28. The Exercise Pressor Reflex in Cardiomyopathy
    Mary G Garry; Fiscal Year: 2013
    ..To support this hypothesis, we have determined that the levels of nerve growth factor (NGF), which are essential to the maintenance of a majority of group IV afferent neurons is significantly ..
  29. Regulation of Cellular Signaling Pathways by POSH
    CHARLES KENNETH KASSENBROCK; Fiscal Year: 2012
    ..levels has been reported to reduce apoptosis in neurons and neuronally differentiated PC12 cells following nerve growth factor withdrawal, as well as in a rodent model of stroke...
  30. Mechanisms/Treatments of Lower Urinary Tract Dysfunction After Spinal Cord Injury
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..be tested include botulinum neurotoxin serotype A, |33-adrenergic receptor agonists, PDE-5 inhibitrors, and nerve growth factor and brain-derived neurotrophic factor antibodies...
  31. A Phase 2 Trial of AAV-NGF Gene Delivery in Alzheimer's Disease
    Paul S Aisen; Fiscal Year: 2012
    b>Nerve Growth Factor (NGF) potently prevents the death and augments the functional state of cholinergic neurons of the basal forebrain, a cell population that undergoes extensive degeneration in Alzheimer disease (AD)...
  32. Structural and Functional Specificity of Rab GTPases
    Guangpu Li; Fiscal Year: 2013
    ..the need for regulation of specialized cell differentiation processes in higher eukaryotes, such as nerve growth factor (NGF)-mediated neuronal differentiation and survival, will be investigated...
  33. Longitudinal Population-Based Study of Vulvodynia
    Barbara D Reed; Fiscal Year: 2012
    ..been found to be associated with chronic pain syndromes in general [Catechol-O-Methyltransferase (COMT) and Nerve Growth Factor receptors (NGF-r)], and vulvodynia in particular [Interleukin-1 receptor antagonist (IL1RN) and ..
  34. Investigation of MeCP2 Function in Rett Syndrome
    N Carolyn Schanen; Fiscal Year: 2010
    ..We will also characterize the role of nerve growth factor and target innervation in regulation of Mecp2 expression and function in sympathetic neurons and determine ..
  35. MECHANISMS OF NERVE GROWTH CONE TURNING AND BRANCHING
    Paul C Letourneau; Fiscal Year: 2013
    The experiments in this proposal investigate how two guidance cues, nerve growth factor (NGF) and Semaphorin3A (Sema3A), regulate the migration of the growing tips (growth cones) of sensory (DRG) axons...
  36. In vivo feasibility of a peripheral nerve imaging agent
    Stephen B Kahl; Fiscal Year: 2013
    ..nerve imaging agent or "nerve paint" comprised of a NearInfrared (NIR) dye conjugated to recombinant human Nerve Growth Factor (rhNGF) (rhNGF-NIR). The goal of this proposal is to show that rhNGF-NIR can be visualized...
  37. METASTATIC PROSTATE CANCER-INDUCED BONE PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2013
    ..While these prostate cancer cells do not express nerve growth factor (NGF), preliminary data suggest their associated stromal cells release NGF that induces dramatic sprouting ..
  38. Mechanism of Neurotrophin Latency Response in a HSV1 Vestibular Neuritis Model
    PAMELA CAROL ROEHM; Fiscal Year: 2013
    ..In cultured cervical sympathetic ganglia, nerve growth factor (NGF) is necessary for maintenance of the latent state, and withdrawal of NGF from cell culture media ..
  39. Acute and Chronic Afferent Engagement: Sympathetic and End Organ Responses
    Lawrence I Sinoway; Fiscal Year: 2013
    ..Dr. Li will also examine the role nerve growth factor (NGF) plays in this response. In Project 3, Dr...
  40. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
    ..Previous research indicates that inflammatory mediators, particularly nerve growth factor (NGF), released from inflamed tissues play an important role in sensitization of afferent nerves and ..
  41. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    ..cell death occurs when neurons fail to receive adequate survival signals from trophic factors such as nerve growth factor (NGF)...
  42. Discovering a Novel Immunophilin to Lower the Toxicity of Cancer Therapeutics
    Mitchell W Mutz; Fiscal Year: 2012
    ..in understanding the mechanistic underpinnings of peripheral neuropathies including CIPN and the role of nerve growth factor (NGF)...
  43. Nerve Growth Factor Signaling in Painful Diabetic Neuropathy
    Hsinlin Thomas Cheng; Fiscal Year: 2013
    ..These signs of DNP correspond with nerve growth factor (NGF) up-regulation, tropomysin-related kinase (Trk) A receptor activation, subsequent p38 kinase ..
  44. Prolyl Hydroxylation and Neuronal Cell Death
    Robert S Freeman; Fiscal Year: 2012
    ..die because they fail to receive adequate supplies of target-derived, survival promoting factors such as nerve growth factor (NGF)...
  45. Developmental plasticity of micturation reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2012
    ..a multidisciplinary experimental approach involving a rat model as well as a novel, chronic overexpressing nerve growth factor (NGF) mouse line (UPII-NGFv2)...
  46. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2013
    ..abnormally susceptible to neurogenic inflammation through mechanisms involving the increased expression of nerve growth factor (NGF) and its trkA and p75 receptors, and we have confirmed overexpression of neurotrophic factors [NGF and ..
  47. Corneal Confocal Microscopy: a non-invasive surrogate for diabetic neuropathy
    RAYAZ AHMED MALIK; Fiscal Year: 2012
    ..Finally, we will explore the role of tear nerve growth factor expression in relation to corneal nerve morphology to provide insights into the pathogenesis of corneal and ..
  48. Imaging NGF signal transduction in live neurons
    Bianxiao Cui; Fiscal Year: 2010
    Our broad objective is to understand the mechanisms by which the nerve growth factor (NGF) signal is propagated from the axon terminal to the cell body...
  49. Receptor tyrosine kinase signaling and influenza viral RNA synthesis
    Yuying Liang; Fiscal Year: 2013
    ..We have preliminary data to suggest that host nerve growth factor (NGF) receptor TrkA signaling plays important roles in the influenza viral replication at the step of viral ..
  50. Neurotrophins in Pancreas Development
    Rejji Kuruvilla; Fiscal Year: 2012
    ..In the pancreas, in vitro studies have shown that the neurotrophin, Nerve Growth Factor, (NGF) regulates survival and function of insulin-producing [unreadable]-cells...
  51. Molecular mechanisms of diabetic retinopathy
    Azza B el-Remessy; Fiscal Year: 2013
    ..For this proposal, our objective is to understand how disruption of nerve growth factor (NGF) homeostasis in diabetes can lead to accumulation of its precursor proNGF and upregulation of the ..
  52. The role of Trib3 in neuronal apoptosis caused by NGF deprivation
    NEELA NONE ZAREEN; Fiscal Year: 2011
    b>Nerve growth factor (NGF) is required for maturation of sympathetic and sensory neurons of the peripheral nervous system (PNS)...
  53. Uncovering polyadenylation pathways in neuronal signaling
    Samie R Jaffrey; Fiscal Year: 2013
    ..the specific aims of this proposal are: (1) To profile polyadenylation events that mediate the effects of nerve growth factor (NGF) and Semaphorin 3A (Sema3A)...
  54. The role of the von-Hippel Lindau protein in developmental cell death in neurons
    KATHLEEN M MCAVOY; Fiscal Year: 2011
    ..Lee et al. (2005) showed that suppression of the VHL protein (pVHL) confers a survival advantage to nerve growth factor (NGF)-deprived sympathetic- neuron-like pheochromocytoma cells (PCI 2 cells)...
  55. P75NTR Small Molecule Ligands for Down Syndrome Therapy
    Frank M Longo; Fiscal Year: 2013
    ..An alteration most notably associated with DS is reduction of nerve growth factor, which binds to p75NTR expressed by basal forebrain cholinergic neurons (BFCN), the degeneration of which ..
  56. Neurotrophin Signaling and Regulation of Gene Expression
    David D Ginty; Fiscal Year: 2010
    ..b>Nerve growth factor (NGF) is the prototypical target derived neurotrophic growth factor...
  57. Neurotrophin mechanisms in neural development and disease
    Rejji Kuruvilla; Fiscal Year: 2013
    ..We previously reported that two different neurotrophins, Nerve Growth Factor (NGF) and Neurotrophin-3 (NT-3), employ the same TrkA receptor to promote sequential stages of axonal ..
  58. Neurotrophin signals controlling development of the peripheral nervous system
    David D Ginty; Fiscal Year: 2013
    ..experiments address mechanisms and functions of the prototypical target-derived neurotrophic growth factor, nerve growth factor (NGF), and its receptor TrkA...
  59. Delta-Opioid Receptor Trafficking and Pain Inhibition
    Zhizhong Z Pan; Fiscal Year: 2012
    ..In our preliminary studies exploring the issue recently, we have discovered that nerve growth factor (NGF), a neurotrophin with diverse functions in neuronal growth and differentiation, can trigger and ..
  60. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
    ..for driving neuropathic pain include TrkA-positive nociceptors that have received excessive amounts of nerve growth factor (NGF);and that this excessive NGF can be derived either from collateral sprouting of uninjured nociceptors ..
  61. cAMP signaling in melanoma pathogenesis: Evidence for multiple microdomains playi
    Jonathan Hale Zippin; Fiscal Year: 2013
    ..In the past, I have used these reagents to establish the role of sAC in nerve growth factor-induced Rap activation in PC-12 cells, netrin-induced growth cone chemotaxis in primary neurons, and ..
  62. Investigating the feasibility of a novel brain delivery stystem based on STrAPs
    PANKAJ SAKHARAM KARANDE; Fiscal Year: 2013
    ..2, we propose to test STrAPs for their ability to deliver model drugs (dextrans) and a representative drug (nerve growth factor, NGF) across an in vitro model of the human BBB...
  63. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ..This projection system is one of the few to express nerve growth factor (NGF). Both NGF and acetylcholine are essential for maintaining neuronal plasticity...
  64. Human Choriogonadotropin Signaling in Cell Proliferation
    MICHAEL HUDECKI; Fiscal Year: 2003
    ..Structurally, hCG is similar in some respects to tumor growth factor (TGF)-Beta, nerve growth factor (NGF) and platelet-derived growth factor (PDGF)-Beta...
  65. RETROVIRAL GENE TRANSFER INTO PRIMARY ASTROCYTE
    MARION SHORT; Fiscal Year: 1992
    ..In this model, genes for B-nerve growth factor (B-NGF) and B-galactosidase (B-gal) will be transferred into cultured neonatal rat, type 1 astrocytes...
  66. DEXAMETHASONE/NGF REGULATE CASEIN KINASE IN PC12 CELLS
    Robert Van Buskirk; Fiscal Year: 1990
    b>Nerve growth factor has been shown to be crucial for the differentiation of several neural lines including sympathetic neurons, adrenal chromaffin cells and the rat pheochromocytoma cell line, PC12...
  67. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
    ..We recently showed that there is little mature nerve growth factor (NGF) and that high molecular weight (MW) NGF species are predominant in peripheral neurons and target ..
  68. MOLECULAR BASIS OF NERVE GROWTH FACTOR
    Jeffrey Milbrandt; Fiscal Year: 1993
    b>Nerve growth factor (NGF) is an important modulator of neuronal development and survival...
  69. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
    ..g., nerve growth factor (NGF); brain derived neurotrophic factor (BDNF); neurotrophin-3 (NT-3)] collaborate in the differentiation ..
  70. NEUROPLASTICITY OF THE AGING BLADDER
    Toby Chai; Fiscal Year: 2000
    ..In these conditions, symptoms may arise from altered innervation of the bladder in response to changes in nerve growth factor (NGF) production...
  71. Cholinergic and cognitive decline in response to TrkA knockdown using RNAi
    Vinay Parikh; Fiscal Year: 2009
    ..Disruption of nerve growth factor (NGF) signaling via tyrosine kinase receptor (TrkA) receptors has been hypothesized to result in the ..
  72. Role of poly(ADP-ribosyl)ation in diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2004
    ..The RATIONALE is based on the: 1) key role of oxidative stress in nerve blood flow (NBF), conduction and nerve growth factor (NGF) deficits of PDN; 2) key role of poly(ADP-ribosyl)ation in free radical damage in numerous pathologies ..