brain derived neurotrophic factor

Summary

Summary: A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

Top Publications

  1. ncbi Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    Nadia M Tsankova
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:519-25. 2006
  2. ncbi Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    Yukihiko Shirayama
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3251-61. 2002
  3. ncbi The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
  4. ncbi Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
  5. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
  6. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
  7. ncbi Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
  8. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
  9. ncbi ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
  10. ncbi Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    C Zuccato
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Science 293:493-8. 2001

Research Grants

  1. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
  2. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
  3. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
  4. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
  5. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
  6. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
  7. Signaling Mechanisms in Alcohol Drinking Behaviors
    Subhash C Pandey; Fiscal Year: 2013
  8. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
  9. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
  10. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013

Detail Information

Publications393 found, 100 shown here

  1. ncbi Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    Nadia M Tsankova
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:519-25. 2006
    ..These experiments underscore an important role for histone remodeling in the pathophysiology and treatment of depression and highlight the therapeutic potential for histone methylation and deacetylation inhibitors in depression...
  2. ncbi Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    Yukihiko Shirayama
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3251-61. 2002
    ..Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance. The results provide further support for the hypothesis that BDNF contributes to the therapeutic action of antidepressant treatment...
  3. ncbi The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  4. ncbi Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
    ....
  5. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  6. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    ..inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective ..
  7. ncbi Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
    ..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression...
  8. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  9. ncbi ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
    ..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins...
  10. ncbi Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    C Zuccato
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Science 293:493-8. 2001
    ..This leads to insufficient neurotrophic support for striatal neurons, which then die. Restoring wild-type huntingtin activity and increasing BDNF production may be therapeutic approaches for treating HD...
  11. ncbi Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
    Laurent R Gauthier
    Unité Mixte de Recherche 146, Centre National de la Recherche Scientifique, Institut Curie, Building 110, Centre Universitaire, 91405 Orsay Cedex, France
    Cell 118:127-38. 2004
    ..Our findings indicate that a key role of huntingtin is to promote BDNF transport and suggest that loss of this function might contribute to pathogenesis...
  12. ncbi New insights into BDNF function in depression and anxiety
    Keri Martinowich
    Mood and Anxiety Program, National Institute of Mental Health, Building 35, Room 1C1004, 35 Convent Drive, MSC 3714, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 10:1089-93. 2007
    ..Opposing influences of mBDNF and proBDNF on long-term potentiation and long-term depression might contribute to the dichotomy of BDNF actions on behaviors mediated by the brain stress and reward systems...
  13. ncbi Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Nat Genet 35:76-83. 2003
    ..These data identify a new mechanism by which mutation of huntingtin causes loss of transcription of neuronal genes...
  14. ncbi Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
    S L Patterson
    Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Neuron 16:1137-45. 1996
    ..Thus, BDNF has an acute role in hippocampal synaptic function...
  15. pmc BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
    Yuan Lu
    Gene, Cognition and Psychosis Program GCAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neurobiol Learn Mem 89:312-23. 2008
    ..Finally, specific roles of BDNF in the acquisition, retention or extinction of LTM remain to be established...
  16. ncbi Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    Jaewon Lee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 82:1367-75. 2002
    ....
  17. pmc Mouse and rat BDNF gene structure and expression revisited
    Tamara Aid
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    J Neurosci Res 85:525-35. 2007
    ..Finally, we confirm that mouse and rat BDNF gene loci do not encode antisense mRNA transcripts, suggesting that mechanisms of regulation for rodent and human BDNF genes differ substantially...
  18. ncbi Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication
    B Chen
    Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada
    Biol Psychiatry 50:260-5. 2001
    ..CONCLUSIONS: These findings are consistent with recent studies measuring CREB levels in this same subject sample, and support current animal and cellular models of antidepressant function...
  19. pmc BDNF regulates eating behavior and locomotor activity in mice
    S G Kernie
    Center for Developmental Biology, U T Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75235 9133, USA
    EMBO J 19:1290-300. 2000
    ..Thus, we identify a novel non-neurotrophic function for neurotrophins and indicate a role in behavior that is remarkably sensitive to alterations in BDNF activity...
  20. ncbi Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo
    Elhoucine Messaoudi
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 27:10445-55. 2007
    ..Furthermore, Arc synthesis is required for both the induction and consolidation of LTP elicited by local BDNF infusion, thus identifying Arc as a key molecular effector of BDNF in synaptic plasticity...
  21. pmc Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
    M Korte
    Max Planck Institut fur Psychiatrie, Munich Martinsried, Germany
    Proc Natl Acad Sci U S A 92:8856-60. 1995
    ..These results suggest that BDNF might have a functional role in the expression of LTP in the hippocampus...
  22. ncbi Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
    Helen Scharfman
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, NY State Department of Health, Rte 9W, West Haverstraw, NY 10993 1195, USA
    Exp Neurol 192:348-56. 2005
    ....
  23. ncbi Is it time to reassess the BDNF hypothesis of depression?
    J O Groves
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 12:1079-88. 2007
    ....
  24. ncbi Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery
    Y Li
    Department of Neurology, Henry Ford Health Sciences Center, Detroit 48202, USA
    Neurology 59:514-23. 2002
    ..To test the effect of i.v.-injected human bone marrow stromal cells (hMSC) on neurologic functional deficits after stroke in rats...
  25. ncbi BDNF is upregulated by postnatal development and visual experience: quantitative and immunohistochemical analyses of BDNF in the rat retina
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, and Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Invest Ophthalmol Vis Sci 44:3211-8. 2003
    ..This study sought to elucidate changes in the levels and distribution of brain-derived neurotrophic factor (BDNF) in the retina throughout aging and depending on visual experience...
  26. ncbi Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
    Newton H Woo
    Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 8:1069-77. 2005
    ....
  27. pmc Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters
    Priit Pruunsild
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia
    Genomics 90:397-406. 2007
    ..We show that BDNF and antiBDNF transcripts form dsRNA duplexes in the brain in vivo, suggesting an important role for antiBDNF in regulating BDNF expression in human...
  28. ncbi Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    Sirith Douma
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Nature 430:1034-9. 2004
    ....
  29. ncbi DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    Keri Martinowich
    Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Science 302:890-3. 2003
    ..Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity...
  30. ncbi Brain-derived neurotrophic factor/TrkB signaling in memory processes
    Kiyofumi Yamada
    Laboratory of Experimental Therapeutics, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 0934, Japan
    J Pharmacol Sci 91:267-70. 2003
    ..A Src-family tyrosine kinase, Fyn plays a role in this interaction by linking TrkB with NR2B. These findings suggest that BDNF/TrkB signaling in the hippocampus plays a crucial role in learning and memory...
  31. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ....
  32. ncbi Multiple promoters direct tissue-specific expression of the rat BDNF gene
    T Timmusk
    Department of Medical Chemistry II, Karolinska Institute, Stockholm, Sweden
    Neuron 10:475-89. 1993
    ..Combined, the data demonstrate that alternative usage of four promoters within the BDNF gene and differential splicing control tissue-specific and seizure-induced expression of BDNF mRNA...
  33. ncbi Acceleration of visual system development by environmental enrichment
    Laura Cancedda
    Scuola Normale Superiore, Laboratorio di Neurobiologia, 56100 Pisa, Italy
    J Neurosci 24:4840-8. 2004
    ..Thus, rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development as ascertained at behavioral, electrophysiological, and molecular level...
  34. ncbi Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I
    Akiko Tabuchi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, Japan
    J Biol Chem 277:35920-31. 2002
    ..These findings support that not only CREB but also USF1/USF2 contributes to Ca(2+) signal-mediated activation of BDNF-PI through the recognition of an overlapping CRE and USF-binding element...
  35. ncbi Mechanism of TrkB-mediated hippocampal long-term potentiation
    Liliana Minichiello
    European Molecular Biology Laboratory, Via Ramarini 32, 00016, Monterotondo, Italy
    Neuron 36:121-37. 2002
    ..Our results provide genetic evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV and CREB...
  36. ncbi Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 61:187-97. 2007
    ....
  37. pmc The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
    R Klein
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Cell 66:395-403. 1991
    ..Finally, 125I-NT-3 binds to NIH 3T3 cells expressing gp145trkB; binding can be competed by NT-3 and BDNF but not by NGF. These findings indicate that gp145trkB may function as a neurotrophic receptor for BDNF and NT-3...
  38. ncbi Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia
    Rachel Groth
    Department of Biology, Macalester College, 1600 Grand Ave, Saint Paul, MN 55105, USA
    Pain 100:171-81. 2002
    ....
  39. ncbi Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
    W R Schäbitz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 31:2212-7. 2000
    ..In this experiment we studied the effect of intravenous BDNF delivered after focal cerebral ischemia on neurological outcome, infarct size, and expression of proapoptotic and antiapoptotic proteins Bax and Bcl-2, respectively...
  40. pmc BDNF is essential to promote persistence of long-term memory storage
    Pedro Bekinschtein
    Instituto de Biología Celular y Neurociencias and Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 105:2711-6. 2008
    ..Thus, BDNF is not only necessary, but sufficient to induce a late postacquisition phase in the hippocampus essential for persistence of LTM storage...
  41. pmc Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    M Hofer
    Max Planck Institute for Psychiatry, Department of Neurochemistry, Martinsried, FRG
    EMBO J 9:2459-64. 1990
    ..The BDNF mRNA was localized by in situ hybridization in hippocampal neurons (pyramidal and granule cells). These data suggest that BDNF may play an important role in the CNS for a wide variety of adult neurons...
  42. ncbi Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    M Rios
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Mol Endocrinol 15:1748-57. 2001
    ..Our results demonstrate that brain derived neurotrophic factor has an essential maintenance function in the regulation of anxiety-related behavior and in food ..
  43. pmc Brain-derived neurotrophic factor
    Devin K Binder
    Department of Neurological Surgery, M779 Moffitt Hospital, Box 0112, University of California, San Francisco, CA 94143 0112, USA
    Growth Factors 22:123-31. 2004
    ....
  44. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
  45. pmc Neuronal release of proBDNF
    Jianmin Yang
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
    Nat Neurosci 12:113-5. 2009
    ..Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB...
  46. ncbi Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    Mikko Sairanen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 25:1089-94. 2005
    ..These data suggest that antidepressants increase turnover of hippocampal neurons rather than neurogenesis per se and that BDNF signaling is required for the long-term survival of newborn neurons in mouse hippocampus...
  47. ncbi Synapsins as mediators of BDNF-enhanced neurotransmitter release
    J N Jovanovic
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Nat Neurosci 3:323-9. 2000
    ..These results indicate a causal link of synapsin phosphorylation via BDNF, TrkB receptors and MAP kinase with downstream facilitation of neurotransmitter release...
  48. pmc Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
    K R Jones
    Howard Hughes Medical Institute University of California, San Francisco School of Medicine 94143
    Cell 76:989-99. 1994
    ..In contrast with mice lacking the BDNF receptor TrkB, motor neurons appear normal in the BDNF mutant...
  49. ncbi Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  50. ncbi Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
    Tomoya Matsumoto
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Nat Neurosci 11:131-3. 2008
    ..Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input...
  51. ncbi Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
    Andrew D Strand
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 27:11758-68. 2007
    ..Based on these findings, we present a testable model of HD pathogenesis that, unlike most models, begins to account for regional specificity in human HD and the absence of such specificity in genetic mouse models of HD...
  52. pmc Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction
    Liqi Tong
    University of California Irvine, Institute for Brain Aging and Dementia, Irvine, CA 92697 4540, USA
    Neurobiol Aging 29:1380-93. 2008
    ..These results suggest that IL-1 beta places neurons at risk by interfering with BDNF signaling involving a ceramide-associated mechanism...
  53. ncbi Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: effects of brain-derived neurotrophic factor and fibroblast growth factor
    Josef M Miller
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci Res 85:1959-69. 2007
    ..Neurotrophic factor treatment therefore has the potential to improve the benefits of cochlear implants by maintaining a larger excitable population of neurons and inducing neural regrowth...
  54. ncbi Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor
    N Tartaglia
    Unit on Synapse Development and Plasticity, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:37585-93. 2001
    ..However, BDNF did not activate PKA, and application of a PKA activator did not mimic the BDNF effect. Taken together, these results suggest a novel, protein synthesis-dependent form of BDNF modulation that requires cAMP gating...
  55. ncbi p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells
    Kaylene M Young
    Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
    J Neurosci 27:5146-55. 2007
    ....
  56. ncbi Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expression
    Vanja Duric
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Pain 7:544-55. 2006
    ....
  57. ncbi Effects of brain-derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development
    S Djalali
    AG Functional Cell Biology Centre for Anatomy, Charité Hochschulmedizin Berlin, Phillippstrasse 12, 10115 Berlin, Germany
    J Neurochem 92:616-27. 2005
    ..Therefore BDNF might indirectly influence the development of the serotonergic system by stimulating the expression of S100beta in astrocytes and the production MBP in oligodendrocytes...
  58. ncbi Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    Xiaomei Sun
    Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, PR China
    Int J Dev Neurosci 26:363-70. 2008
    ....
  59. pmc CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Clin Pathol 129:526-9. 2008
    ..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...
  60. ncbi Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model
    Xiao Ping He
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 43:31-42. 2004
    ..Its requirement for epileptogenesis in kindling implicates TrkB and downstream signaling pathways as attractive molecular targets for drugs for preventing epilepsy...
  61. ncbi Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model
    Keith R G Martin
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 44:4357-65. 2003
    ....
  62. ncbi Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia
    C S Weickert
    Clinical Brain Disorders Branch, NIMH, IRP, NIH, Bethesda, MD 20892 1385, USA
    Mol Psychiatry 8:592-610. 2003
    ..Our study demonstrates a reduction in BDNF production and availability in the DLPFC of schizophrenics, and suggests that intrinsic cortical neurons, afferent neurons, and target neurons may receive less trophic support in this disorder...
  63. ncbi Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
    S Arancibia
    Univ Montpellier 2, Montpellier, F 34095, France
    Neurobiol Dis 31:316-26. 2008
    ..We conclude that BDNF possesses neuroprotective properties against toxic effects of Abeta peptides...
  64. ncbi Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
    Josep M Canals
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    J Neurosci 24:7727-39. 2004
    ..Hence, administration of exogenous BDNF may delay or stop illness progression...
  65. ncbi Epithelial overexpression of BDNF or NT4 disrupts targeting of taste neurons that innervate the anterior tongue
    R F Krimm
    Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    Dev Biol 232:508-21. 2001
    ....
  66. ncbi Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats
    M L Ko
    Department of Physiology, National Taiwan University, Section 1, Jen-Ai Road, 10018, Taipei, Taiwan
    Neurosci Lett 305:139-42. 2001
    ..These findings demonstrated that BDNF has partial neuroprotection on RGCs in whole retina and enhances RGC survival in moderately chronic hypertensive eyes...
  67. pmc Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions
    M Lommatzsch
    Department of Laboratory Medicine, Charite, Humboldt University, Berlin, Germany
    Am J Pathol 155:1183-93. 1999
    ..The abundance of BDNF protein in certain internal organs suggests that this neurotrophin may regulate the function of adult visceral sensory and motor neurons...
  68. ncbi Molecular cloning and expression of brain-derived neurotrophic factor
    J Leibrock
    Max Planck Institute for Psychiatry, Department of Neurochemistry, Planegg Martinsried, FRG
    Nature 341:149-52. 1989
    ..These results establish that these two neurotrophic factors are related both functionally and structurally...
  69. ncbi Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment
    R Hellweg
    Central Institute of Mental Health, Mannheim, Germany
    Pharmacopsychiatry 41:66-71. 2008
    ..Recent research suggests that serum BDNF concentration is reduced in depression and that successful antidepressant treatment leads to an increase in serum BDNF concentration...
  70. ncbi Association between BDNF Val66Met polymorphism and age at onset in Huntington disease
    J Alberch
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Neurology 65:964-5. 2005
  71. ncbi Variant BDNF (Val66Met) impact on brain structure and function
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USA
    Cogn Affect Behav Neurosci 6:79-85. 2006
    ..We review the recent literature linking this BDNF polymorphism to cognitive impairment in the context of in vitro and transgenic animal studies that have established BDNF's central role in neuronal functioning in the adult brain...
  72. ncbi The trophic role of oligodendrocytes in the basal forebrain
    Xudong Dai
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 23:5846-53. 2003
    ..Our studies support a novel role for OLGs in providing local trophic support for neurons in the CNS...
  73. ncbi A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
    Giles S H Yeo
    University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    Nat Neurosci 7:1187-9. 2004
    ..The associated impairment in memory, learning and nociception seen in the proband reflects the crucial role of TrkB in the human nervous system...
  74. ncbi Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women
    James Currie
    School of Life Sciences, Oxford Brookes University, United Kingdom
    Neurosci Lett 451:152-5. 2009
    ..This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF...
  75. ncbi Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation
    Hironobu Fujimura
    Otsuka Maryland Research Institute, LLC, Rockville 20850, USA
    Thromb Haemost 87:728-34. 2002
    ..Platelets appear to bind, store and release BDNF upon activation at the site of traumatic injury to facilitate the repair of peripheral nerves or other tissues that contain TrkB...
  76. ncbi Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress
    Li Song
    Department of Pharmacology, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Pharmacol Biochem Behav 83:186-93. 2006
    ..These two models also increased the plasma corticosterone concentration and decreased the brain derived neurotrophic factor (BDNF) and cAMP-response element-biding protein (CREB) messenger ribonucleic acid (mRNA) levels in ..
  77. ncbi Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo
    Ying Gao
    Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuron 44:609-21. 2004
    ..These results indicate that CREB plays a central role in overcoming myelin inhibitors and so encourages regeneration in vivo...
  78. ncbi Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus
    Pedro Bekinschtein
    Instituto de Biologia Celular y Neurociencias, UBA, Buenos Aires C1121ABG, Argentina
    Neuron 53:261-77. 2007
    ..We propose that memory formation and memory persistence share some of the same molecular mechanisms and that recurrent rounds of consolidation-like events take place in the hippocampus for maintenance of the memory trace...
  79. ncbi The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival
    Melissa M Grant
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Proteomics 5:534-40. 2005
    ..g. acyl CoA oxidase 3) and induced brain derived neurotrophic factor (BDNF) expression...
  80. ncbi Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    M Hetman
    Toxicology Program, Department of Environmental Health, the Graduate Program in Neurobiology and Behavior, The Graduate Program in Molecular and Cell Biology, University of Washington, Seattle, Washington 98195 7234, USA
    J Biol Chem 274:22569-80. 1999
    ..Furthermore, the relative contribution of the ERK and PI 3-kinase pathways to neuronal survival may depend on the type of cellular injury...
  81. ncbi Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone
    M J Schaaf
    Leiden Amsterdam Center for Drug Research, Division of Medical Pharmacology, Sylvius Laboratories, P O Box 9503, 2300 RA, Leiden, The Netherlands
    Brain Res 813:112-20. 1998
    ..In conclusion, we have found a transient, dose-dependent decrease in BDNF mRNA and protein in the hippocampus, which may underly changes in neuronal plasticity in the hippocampus after short-term changes in corticosterone concentrations...
  82. ncbi Functional regeneration of sensory axons into the adult spinal cord
    M S Ramer
    Neuroscience Research Centre, Guy s, King s and St Thomas School of Biomedical Sciences, London, UK
    Nature 403:312-6. 2000
    ..Neurotrophic factor treatment may thus serve as a viable treatment in promoting recovery from root avulsion injuries. I..
  83. ncbi The p75 neurotrophin receptor and neuronal apoptosis
    G L Barrett
    Department of Physiology, University of Melbourne, Parkville, Australia
    Prog Neurobiol 61:205-29. 2000
    ..Another major challenge is to develop a model that reconciles the different facets of p75, such as its ability in some situations to assist TrkA to rescue NGF-dependent neurons, but to stimulate apoptosis in others...
  84. ncbi Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease
    Bernadeta Michalski
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    Brain Res Mol Brain Res 111:148-54. 2003
    ..Although the biological activity of proBDNF is unknown, reduced proBDNF may have functional consequences for the selective neuronal degeneration in Alzheimer's disease brain...
  85. ncbi BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs
    Sandra M Garraway
    Department of Neurobiology and Behaviour, State University of New York, Stony Brook NY 11794 5230, USA
    Eur J Neurosci 18:2467-76. 2003
    ..This action of BDNF may contribute to central sensitization and exaggerated pain states...
  86. ncbi Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning
    Lisa M Rattiner
    Emory University School of Medicine, Center for Behavioral Neuroscience, Yerkes Research Center, Atlanta, Georgia 30329, USA
    J Neurosci 24:4796-806. 2004
    ..T1 lentivirus blocked fear acquisition without disrupting baseline startle or expression of fear. These data suggest that BDNF signaling through TrkB receptors in the amygdala is required for the acquisition of conditioned fear...
  87. ncbi A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:1604-11. 2004
    ..These data suggest that BDNF-mediated neuroadaptations in mesolimbic areas are involved in the persistent cocaine seeking induced by exposure to drug cues after withdrawal...
  88. pmc Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat
    L Delafoy
    Pfizer Global Research and Development, Fresnes Laboratories, France
    Gut 55:940-5. 2006
    ..Based on data on brain derived neurotrophic factor (BDNF) and calcitonin gene related peptide (CGRP) in pain, the aims of the present study were: (1) ..
  89. ncbi Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites
    Jessica A Gorski
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 23:6856-65. 2003
    ..This is consistent with a role for BDNF in stabilizing the "survival" of circuitry during the phase of activity-dependent reorganization of cortical connectivity...
  90. ncbi Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury
    Kumi Nagamoto-Combs
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    J Neurotrauma 24:1719-42. 2007
    ..These results demonstrate that microglia/macrophage undergo prolonged activation after TBI in the non-human primate brain and express BDNF and its receptors, suggesting their tropic/trophic roles in the long-term recovery processes...
  91. ncbi Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus
    Masataka Suwa
    Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
    Metabolism 55:852-7. 2006
    ..In addition, the BDNF is related to the total and abdominal subcutaneous fat mass and energy metabolism in the newly diagnosed female patients with type 2 diabetes mellitus...
  92. pmc Role of the brain-derived neurotrophic factor at glutamatergic synapses
    A L Carvalho
    Center for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal
    Br J Pharmacol 153:S310-24. 2008
    ..This review focuses on recent advances in the understanding of the regulation of the glutamatergic synapse by BDNF, and its implications in synaptic plasticity...
  93. ncbi The impact of age, weight and gender on BDNF levels in human platelets and plasma
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Neurobiol Aging 26:115-23. 2005
    ..In addition, platelet BDNF levels changed during the menstrual cycle. In conclusion, we demonstrate that parameters such as age or gender have a specific impact on stored and circulating BDNF levels in peripheral blood...
  94. ncbi The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression
    C Montag
    Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany
    Psychol Med 39:1831-9. 2009
    ..Given that stress-induced atrophy of the hippocampus is associated with the pathogenesis of affective disorders, the functional BDNF Val66Met polymorphism could be an incremental risk factor...
  95. ncbi Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo
    Karin Wibrand
    Department of Biomedicine and Bergen Mental Health Research Center, Section for Physiology, University of Bergen, Jonas Liens vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 23:1501-11. 2006
    ..These results provide novel insight into gene expression responses underlying BDNF-induced synaptic consolidation in the adult brain in vivo...
  96. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003
    ..These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T...
  97. pmc The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB
    B Xu
    Howard Hughes Medical Institute, Program in Neuroscience and Department of Physiology, University of California, San Francisco, California 94143, USA
    J Neurosci 20:6888-97. 2000
    ..Thus, BDNF appears to act through TrkB presynaptically, but not postsynaptically, to modulate LTP...
  98. ncbi STAT3 as a downstream mediator of Trk signaling and functions
    Yu Pong Ng
    Department of Biochemistry, Biotechnology Research Institute, and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    J Biol Chem 281:15636-44. 2006
    ..Together, our findings have identified STAT3 as an essential component of neurotrophin signaling and functions...
  99. pmc Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo
    Laura Carim-Todd
    Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Neurosci 29:678-85. 2009
    ..Our results suggest that, at the physiological level, TrkB.T1 receptors are important regulators of TrkB.FL signaling in vivo. Moreover, TrkB.T1 selectively affects dendrite complexity of certain neuronal populations...
  100. pmc P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation
    Tuan Trang
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Neurosci 29:3518-28. 2009
    ....
  101. ncbi BDNF as a pain modulator
    Adalberto Merighi
    Dipartimento di Morfofisiologia Veterinaria, University of Turin, Turin, Italy
    Prog Neurobiol 85:297-317. 2008
    ..Recent studies have unraveled some of the neuronal circuitries and mechanisms involved, highlighting the key role of synaptic glomeruli in lamina II as the main sites for such a modulation...

Research Grants71

  1. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..Hypothesis: FA-NO2 are radioprotective by desensitizing TRPA1 and TRPV1 channels and BDNF-AB and NGF-AB are therapeutic by inhibiting nerve growth and sensitization in bladder and spinal cord. ..
  2. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..Our basic research studies could have treatment implications for patients with either MDD and/or PTSD. ..
  3. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ....
  4. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ....
  5. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..the stable downregulation of genes protective against the reinforcing effects of ethanol, such as brain derived neurotrophic factor (BDNF), may result in increased alcohol consumption...
  6. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..By establishing the role of neurotrophins in airway narrowing with or without inflammation, the proposed studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  7. Signaling Mechanisms in Alcohol Drinking Behaviors
    Subhash C Pandey; Fiscal Year: 2013
    ....
  8. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
    ..COR is hypothesized to involve increases in brain derived neurotrophic factor (BDNF) in mesocorticolimbic dopamine neurons such as prefrontal cortex (PFC) and basolateral ..
  9. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ....
  10. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..The objective of this renewal application is to characterize the role of the neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the ..
  11. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..To this end, we propose investigating a promising pharmacological approach that persistently increases respiratory motoneuron function, thereby improving breathing after spinal cord injury. ..
  12. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..This research proposal supports training necessary for the applicant's career goal to become a dentist-scientist studying translational research in regenerative dentistry. ..
  13. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..S. civilians could be adversely affected by highly toxic chemicals released intentionally in terrorist attacks or unintentionally in industrial accidents or natural disasters. ..
  14. NEWBORN IRON DEFICIENCY
    Michael K Georgieff; Fiscal Year: 2013
    ..regulation of growth factors mediating hippocampal plasticity and function in adulthood including Brain Derived Neurotrophic Factor (BDNF) and its downstream effectors...
  15. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..We found that exogenous application of brain derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) delivered from biodegradable ..
  16. Developmental Regulation of Brain and Behavior
    JULI S WADE; Fiscal Year: 2011
    ..protein 1 (SCAMP1), sorting nexin 2 (SNX2), and tyrosine kinase B (the high affinity receptor for brain derived neurotrophic factor, BDNF)...
  17. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ....
  18. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..Neurotrophic factors such as ciliary neurotrophic factor (CNTF) and brain derived neurotrophic factor (BDNF) have been shown to prevent photoreceptor death in animal models of RP13-17, but such ..
  19. Human VGF Polymorphisms and Depression
    Stephen R Salton; Fiscal Year: 2010
    ....
  20. Transcranial Magnetic Stimulation in Pregnant Women with Depressive Disorder
    Deborah Kim; Fiscal Year: 2013
    ..may be effective for the treatment of depression during pregnancy, we will measure maternal serum brain derived neurotrophic factor (BDNF) and correlate it with levels of estradiol, progesterone, allopregnanolone, oxytocin and ..
  21. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ..to genotype a comprehensive panel of NTF and NTF receptors and measure serum levels of three NTF: brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) in the large, ..
  22. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    ....
  23. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Brain derived neurotrophic factor (BDNF) is importantly involved in anxiety, depression and cognitive function...
  24. Role of AIE in Epigenetic and Behavioral Changes at Adulthood
    Subhash C Pandey; Fiscal Year: 2013
    ..The proposed research will help to identify novel epigenetic and molecular targets that can be used to develop future pharmacotherapies to treat adults comorbid with alcoholism and anxiety, due to exposure to alcohol during adolescence. ..
  25. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ....
  26. Mechanisms and Therapeutics for Rett Syndrome
    Mriganka Sur; Fiscal Year: 2013
    ..Since IGF1 is FDA-approved for clinical use in children with growth failure, this study represents a valid approach for a therapeutic intervention on RTT patients. ..
  27. Epigenetic Modifications of BDNF and trkB Genes Underlie Pain Plasticity
    John David Sweatt; Fiscal Year: 2013
    ..The results from the proposed studies may help us to understand treatment-related pain in more detail, and may provide new molecular targets for analgesic therapy. ..
  28. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..We have recently identified a number of high-potency small mimetic molecules of brain derived neurotrophic factor. These compounds readily crossed the blood brain barrier and into the cochlea...
  29. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..By linking antidepressant treatment, sustained sleep, and adult neurogenesis, proposed work could provide a specific neurochemical rationale for development of treatment protocols which include management of sleep disorders. ..
  30. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..The objective of this renewal application is to characterize the role of the neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the ..
  31. Experience-Dependent Redeployment of MeCP2 Across the Mouse Genome
    Qiang Chang; Fiscal Year: 2011
    ..Furthermore, because of the considerable overlap in clinical features between RTT and autistic spectrum disorders, the lessons learned studying RTT might also benefit the general understanding of autism. ..
  32. Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
    Robert S Schwartz; Fiscal Year: 2010
    ..This study will assess novel metabolic treatments for patients with both MCI and MS, with the aim of delaying the progression of these patients to dementia. ..
  33. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    ..The results obtained could have important implications for understanding treatment non-response in some women. ..
  34. Neuronal survival, HIV-1 and Astrocyte TIMP-1
    Anuja Ghorpade; Fiscal Year: 2013
    ..In these assays, TIMP-1 had equivalent neuroprotective effects as brain derived neurotrophic factor (BDNF)...
  35. Effects of Non-Exercise Activity on Cognitive Function in the Elderly
    Teresa J Buracchio; Fiscal Year: 2011
    ..This will reduce the burden on the VA healthcare system and caregivers as well improve quality of life for both patients and their caregivers. ) ..
  36. Ontogenic factors in adolescent-emergent depression and decision-making
    SHANNON LEIGH GOURLEY; Fiscal Year: 2013
    ....
  37. Matrix and trophic coupling in the neurovascular unit
    Eng H Lo; Fiscal Year: 2011
    ..g. brain derived neurotrophic factor, BDNF) that provide trophic support for neuronal health...
  38. Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
    Karin Schon; Fiscal Year: 2011
    ..This set of studies aims to examine the relationship between aging, exercise, and the brain in healthy young and older individuals. ..
  39. Breathing disorders in a mouse model of Rett syndrome
    Chun Jiang; Fiscal Year: 2013
    ....
  40. Neurotrophins and Post-infarct Plasicity in Cardiac Sympathetic Neurons
    Beth A Habecker; Fiscal Year: 2013
    ..This research plan will advance our understanding of the molecular basis for pathological changes in the cardiac sympathetic innervation after infarction, and may facilitate targeted development of novel therapeutics. ..
  41. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..Recently, several lines of evidence from our laboratory and others suggest that brain derived neurotrophic factor (BDNF) plays an important role in energy balance...
  42. VGF function in depression and antidepressant treatment
    Stephen R Salton; Fiscal Year: 2013
    ....
  43. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..Immunocytochemistry for vascular endothelial growth factor (VEGF), its receptor VEGFR-2, brain derived neurotrophic factor (BDNF), its receptor TrkB will be used to identify their expression in HF cells...
  44. TrkB Agonist(s), a Potential Therapy for Autism Spectrum Disorders
    Yi Eve Sun; Fiscal Year: 2010
    ..In addition, altered regulation of brain derived neurotrophic factor (BDNF) has also been found in autistic patients. In RTT mouse models (i.e...
  45. Mechanisms of Valproic Acid-Induced Neurodevelopmental and Behavioral Defects
    Elizabeth M Powell; Fiscal Year: 2013
    ....
  46. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..Activation and inhibition of key players in these pathways, as well as downstream activation of brain derived neurotrophic factor (BDNF) will be tested for their involvement in protecting the striatum and hippocampus from the ..
  47. Mechanisms Underlying Sex-Specific Effects of Creatine Supplementation on Depress
    PATRICIA JOAN ALLEN; Fiscal Year: 2011
    ..This research is highly relevant to public health interests, as creatine is among the most extensively used nutritional supplements to date and the potential for creatine to alter mood may directly impact management of depression. ..
  48. Non-viral gene delivery to neural progenitor cells in the SVZ
    Suzie H Pun; Fiscal Year: 2012
    ..The developed technology would have broad significance as vehicles to deliver therapeutic genes for CNS disorders. ..
  49. Modulating cancer progression by adipogenic human adenovirus type 36
    Lei Cao; Fiscal Year: 2013
    ....
  50. Regulation of BDNF Expression by Calcium-stimulated Protein Kinases
    Hongbing Wang; Fiscal Year: 2010
    ....
  51. Homeostatic Regulation of Presynaptic Function by Dendritic mTORC1
    FREDRICK EARL HENRY; Fiscal Year: 2013
    ....
  52. Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
    Karin Schon; Fiscal Year: 2013
    ..Regular moderate intensity aerobic exercise may have neuroprotective effects throughout the lifespan. ..
  53. Epigenetic modulation of antidepressant efficacy
    Claudia Schmauss; Fiscal Year: 2013
    ..They also examine the role of 5-HT1A and 5-HT2 receptors as well as the role of brain derived neurotrophic factor-mediated trkB-signaling in mediating this effect...
  54. Real-time imaging of tPA fluorescent hybrids in hippocampal neurons
    Janis E Lochner; Fiscal Year: 2011
    ..synaptic plasticity by promoting the cleavage of another secreted neuromodulatory protein, brain derived neurotrophic factor (BDNF)...
  55. In Vivo Efficacy of New Neuroprotective Drugs
    DAVID R SCHUBERT; Fiscal Year: 2010
    ..These compounds have an activity similar to brain derived neurotrophic factor and prevent nerve cell death associated with trophic factor withdrawal, excitotoxicity, glucose ..
  56. BDNF and Spine-Realted Disorders of Memory and Cognition
    Christine M Gall; Fiscal Year: 2013
    ..In all, the proposed studies are expected to test for the presence of a final, common defect in memory disorders and to thoroughly evaluate a clinically relevant strategy for normalizing synaptic plasticity and behavior. ..
  57. Control of Dendritic and Synaptic Development by Extracellular Cues
    GARY ALLEN WAYMAN; Fiscal Year: 2013
    ..The levels of neurotrophic factors like Brain Derived Neurotrophic Factor (BDNF), which stimulates dendritic growth, are decreased in both humans suffering from MDD and in ..
  58. Mechanisms of BDNF and Glucocorticoid Action
    Michael J Garabedian; Fiscal Year: 2013
    ..of glucocorticoids upon neuronal circuits are also strongly influenced by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). However, the molecular mechanism of this regulation has not been explored...
  59. Increased vulnerability of BDNF deficient mice to mild stress
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ..Thus, stress-related psychiatric disorders, such as major depression, may result from a subtle atrophy or diminished function of BDNF- responsive neurons in the brain. ..
  60. In Vivo Function of Neuronal Activity-Induced MeCP2 phosphorylation
    Qiang Chang; Fiscal Year: 2013
    ..Furthermore, because the considerable overlap in clinical features between RTT and autistic spectrum disorders, the lessons learned studying RTT might also benefit the general understanding of autism. ..
  61. GABA(A) Receptor Subunit Regulation in Epileptogenesis
    Shelley J Russek; Fiscal Year: 2013
    ..JAK)/Signal Transducer and Activator of Transcription (STAT) signaling cascade, via actions of brain derived neurotrophic factor (BDNF)...
  62. Role of Sim1 in Hyperphagic Obesity
    Bassil M Kublaoui; Fiscal Year: 2010
    ..receptor-/- (mc4r-/-) mice and Agouti Yellow mice (Ay) but also in mice deficient in bdnf (brain derived neurotrophic factor) and its receptor...
  63. REGULATION OF SODIUM CHANNEL EXPRESSION
    ROBERT MAUE; Fiscal Year: 2000
    ....
  64. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
    ..In addition to NGF and NT-3, both brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) reportedly have regulatory roles in peripheral neurons, yet a ..
  65. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
    ..g., nerve growth factor (NGF); brain derived neurotrophic factor (BDNF); neurotrophin-3 (NT-3)] collaborate in the differentiation and survival of CNS target neurons...
  66. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
    ..These studies will provide new insights into the role of TH in brain development, which may have clinical importance in cretinism and infantile hypothyroidism. ..
  67. Estrogen Signaling and Synaptogenesis in Hippocampus: The Role of BDNF
    Joanna Spencer; Fiscal Year: 2009
    ..The findings will reveal possible mechanisms by which natural and pharmacological ovarian hormones modulate brain function, influencing susceptibility to psychiatric disorders and dementia across the menstrual cycle and lifespan. ..
  68. NEUROTROPHIN ROLE IN OXIDATIVE HOMEOSTASIS AFTER STROKE
    JOSE PEREZ POLO; Fiscal Year: 1999
    ..These studies will provide insights into the mechanism of stroke pathophysiology and suggest new therapeutic approaches. ..
  69. Investigating the Role of Muscle-derived BDNF in Neuromuscular Disease Pathology
    ERICH NORSE OTTEM; Fiscal Year: 2011
    ..This project will act as a foundation for research in this unexplored area and enhance biomedical science research opportunities for undergraduate and graduate students at Northern Michigan University. ! ..
  70. Effects of SLC6A4, BDNF and Ecstasy Use on Brain Structure in Young Adults
    Krista Lisdahl Medina; Fiscal Year: 2010
    ..This information will help tailor drug prevention and biologically based intervention programs. ..
  71. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot S Damaser; Fiscal Year: 2010
    ....