nerve growth factors

Summary

Summary: Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.

Top Publications

  1. pmc Neurotrophins: roles in neuronal development and function
    E J Huang
    Department of Pathology, University of California, San Francisco, California 94143, USA
    Annu Rev Neurosci 24:677-736. 2001
  2. pmc Neurotrophin-regulated signalling pathways
    Louis F Reichardt
    Neuroscience Program, Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, 1550 Fourth Street, Rock Hall 284a, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 361:1545-64. 2006
  3. ncbi Trk receptors: roles in neuronal signal transduction
    Eric J Huang
    Department of Pathology, University of California Veterans Administration Medical Center, San Francisco, California 94143, USA
    Annu Rev Biochem 72:609-42. 2003
  4. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
  5. ncbi Neurotrophins and their receptors: a convergence point for many signalling pathways
    Moses V Chao
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Neurosci 4:299-309. 2003
  6. ncbi Neurotrophin signal transduction in the nervous system
    D R Kaplan
    Brain Tumor Research Center, Montreal Neurological Institute, Montreal, H3A 2B4, Canada
    Curr Opin Neurobiol 10:381-91. 2000
  7. ncbi Neuropilin is a semaphorin III receptor
    A L Kolodkin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cell 90:753-62. 1997
  8. ncbi S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
  9. ncbi Neurotrophins: mediators and modulators of pain
    Sophie Pezet
    The London Pain Consortium, King s College London, The Wolfson Center for Age Related Diseases, SE1 1UL London, United Kingdom
    Annu Rev Neurosci 29:507-38. 2006
  10. pmc Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:447-56. 2009

Research Grants

  1. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
  2. Spatial Considerations in Neuronal Survival Signals
    Rosalind A Segal; Fiscal Year: 2013
  3. BIOLOGY OF ALZHEIMER AMYLOID IN NEURONS
    Gunnar K Gouras; Fiscal Year: 2010
  4. Effects of TrkB Activation on Abnormalities in Neocortical FS Interneurons
    DAVID ALLAN PRINCE; Fiscal Year: 2013
  5. The Role of Novel Angiogenic Signals in Post-Stroke Neurogenesis
    ANDREW JOHN BRUMM; Fiscal Year: 2013
  6. REORGANIZATION AFTER BRAIN INJURY
    JAIME VILLABLANCA; Fiscal Year: 1990
  7. ROLE OF INSULIN-LIKE GROWTH FACTORS IN THE PNS
    Eva Feldman; Fiscal Year: 1993
  8. TOTAL SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    JIN CHA; Fiscal Year: 2007
  9. NERVE GROWTH FACTOR ACTION ON ADULT CNS NEURONS IN VIVO
    SILVIO VARON; Fiscal Year: 1993
  10. CARDIOVASCULAR BIOLOGY AND ATHEROSCLEROSIS
    KATHERINE HAJJAR; Fiscal Year: 2009

Detail Information

Publications285 found, 100 shown here

  1. pmc Neurotrophins: roles in neuronal development and function
    E J Huang
    Department of Pathology, University of California, San Francisco, California 94143, USA
    Annu Rev Neurosci 24:677-736. 2001
    ..These proteins also regulate many aspects of neural function. In the mature nervous system, they control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival...
  2. pmc Neurotrophin-regulated signalling pathways
    Louis F Reichardt
    Neuroscience Program, Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, 1550 Fourth Street, Rock Hall 284a, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 361:1545-64. 2006
    ....
  3. ncbi Trk receptors: roles in neuronal signal transduction
    Eric J Huang
    Department of Pathology, University of California Veterans Administration Medical Center, San Francisco, California 94143, USA
    Annu Rev Biochem 72:609-42. 2003
    ..p75NTR also influences the conformations of Trk receptors; this modifies ligand-binding specificity and affinity with important developmental consequences...
  4. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    ..The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote survival...
  5. ncbi Neurotrophins and their receptors: a convergence point for many signalling pathways
    Moses V Chao
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Neurosci 4:299-309. 2003
  6. ncbi Neurotrophin signal transduction in the nervous system
    D R Kaplan
    Brain Tumor Research Center, Montreal Neurological Institute, Montreal, H3A 2B4, Canada
    Curr Opin Neurobiol 10:381-91. 2000
    ..In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals...
  7. ncbi Neuropilin is a semaphorin III receptor
    A L Kolodkin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cell 90:753-62. 1997
    ..We also describe the identification of neuropilin-2, a related neuropilin family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct, populations of neurons in the rat embryonic nervous system...
  8. ncbi S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
    ..Future studies using S100B transgenic and S100B null mice might shed more light on the functional role(s) of the protein...
  9. ncbi Neurotrophins: mediators and modulators of pain
    Sophie Pezet
    The London Pain Consortium, King s College London, The Wolfson Center for Age Related Diseases, SE1 1UL London, United Kingdom
    Annu Rev Neurosci 29:507-38. 2006
    ..The chapter reviews the evidence for these roles (and briefly the effects of other neurotrophins), the range of conditions under which they act, and their mechanism of action...
  10. pmc Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:447-56. 2009
    ..These findings suggest a pathway in the pathophysiology of glaucoma through loss of neurotrophic function and may eventually open the possibility of using ligands activating TrkB to prevent the progression of the disease...
  11. ncbi Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
    T Yamashita
    Department of Neurobiochemistry, Max Planck Institute of Neurobiology, Martinsried, Federal Republic of Germany
    Neuron 24:585-93. 1999
    ..In vivo, axonal outgrowth was retarded in mice carrying a mutation in the p75NTR gene. These results indicate that p75NTR modulates in a ligand-dependent fashion the activity of intracellular proteins known to regulate actin assembly...
  12. ncbi Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
    C Hock
    Department of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zürich 8, Switzerland
    Arch Neurol 57:846-51. 2000
    ....
  13. ncbi GDNF is a chemoattractant for enteric neural cells
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, 3010, Australia
    Dev Biol 229:503-16. 2001
    ..We conclude that GDNF may promote the migration of crest cells throughout the gastrointestinal tract, prevent them from straying out of the gut (into the mesentery and pharyngeal and pelvic tissues), and promote directed axon outgrowth...
  14. ncbi UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
    S S Chan
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Cell 87:187-95. 1996
    ..Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells...
  15. ncbi Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    M P Sanchez
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Nature 382:70-3. 1996
    ..However, ablation of the GDNF gene does not affect the differentiation and survival of dopaminergic neurons, at least during embryonic development...
  16. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ....
  17. ncbi Neurotrophins are required for nerve growth during development
    K L Tucker
    Department of Neurobiochemistry, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Nat Neurosci 4:29-37. 2001
    ....
  18. ncbi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
    ..We evaluate S100-B protein measurement as a screening tool in a large population of patients with minor head injury...
  19. ncbi Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    C Zuccato
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Science 293:493-8. 2001
    ..This leads to insufficient neurotrophic support for striatal neurons, which then die. Restoring wild-type huntingtin activity and increasing BDNF production may be therapeutic approaches for treating HD...
  20. pmc Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis
    Hua Yang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 51:28-34. 2010
    ..This study investigates whether constitutive overexpression of PEDF inhibits the growth and hepatic micrometastasis of ocular melanoma...
  21. ncbi Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss
    Monica Sabater
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, Instituto de Salud Carlos III, Girona, Spain
    J Clin Endocrinol Metab 95:4720-8. 2010
    ..We aimed to study circulating pigment epithelium-derived factor (PEDF) in vivo in association with insulin resistance and in vitro in human adipocytes...
  22. ncbi Neurotrophin signalling in health and disease
    Moses V Chao
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Clin Sci (Lond) 110:167-73. 2006
    ..In this review, we consider the signalling pathways activated by neurotrophins in both health and disease states...
  23. ncbi Trk receptors: mediators of neurotrophin action
    A Patapoutian
    Department of Cell Biology, The Scripps Research Institute and Genomics Institute, Novartis Research Foundation, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 11:272-80. 2001
    ..Three-dimensional structures of the Trk receptors, in one instance in association with a neurotrophin, have revealed the structural bases underlying specificity in neurotrophin signaling...
  24. ncbi Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis
    Lauren Crigler
    SL 99, Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Exp Neurol 198:54-64. 2006
    ..These subpopulations may represent more potent vectors for treating a variety of neurological disorders...
  25. pmc The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
    Janine M van Gils
    Marc and Ruti Bell Vascular Biology and Disease Program, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA
    Nat Immunol 13:136-43. 2012
    ..Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall. Our results establish a causative role for negative regulators of leukocyte migration in chronic inflammation...
  26. ncbi The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    T Serafini
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452
    Cell 78:409-24. 1994
    ..elegans. This homology suggests that growth cones in the vertebrate spinal cord and the nematode are responsive to similar molecular cues...
  27. ncbi Characterization of PEDF: a multi-functional serpin family protein
    S Filleur
    Department of Urology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6591, Lubbock, Texas 79430 6591, USA
    J Cell Biochem 106:769-75. 2009
    ....
  28. pmc Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
    Julien Fitamant
    Apoptosis, Cancer, and Development Laboratory Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Centre Leon Berard, Université de Lyon 69008 Lyon, France
    Proc Natl Acad Sci U S A 105:4850-5. 2008
    ....
  29. ncbi Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia
    Peter Rosenberger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen 72076, Germany
    Nat Immunol 10:195-202. 2009
    ..Our studies demonstrate that HIF-1alpha-dependent induction of netrin-1 attenuates hypoxia-elicited inflammation at mucosal surfaces...
  30. ncbi Adaptation in the chemotactic guidance of nerve growth cones
    Guo li Ming
    Division of Biology, University of California at San Diego, La Jolla, California 92093, USA
    Nature 417:411-8. 2002
    ..Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis...
  31. pmc Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo
    Riichiro Abe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Pathol 164:1225-32. 2004
    ..PEDF therefore might be a promising novel therapeutic agent for treatment of patients with melanoma...
  32. ncbi Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease
    Ponnalagu Murugeswari
    Department of Immunology, Dr G Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Tamilnadu, India
    Retina 28:817-24. 2008
    ....
  33. pmc Peripheral nerve regeneration and neurotrophic factors
    G Terenghi
    Blond McIndoe Centre, Queen Victoria Hospital, East Grinstead, Sussex, UK
    J Anat 194:1-14. 1999
    ..The studies reviewed in this article show the therapeutic potential of neurotrophic factors for the treatment of peripheral nerve injury and for neuropathies...
  34. ncbi Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    Sarah X Zhang
    Department of Medicine Endocrinology, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    FASEB J 20:323-5. 2006
    ..These findings suggest that PEDF is a novel endogenous anti-inflammatory factor in the eye. The decrease of ocular PEDF levels may contribute to inflammation and vascular leakage in DR...
  35. pmc Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase
    Melissa L Borg
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Diabetes 60:1458-66. 2011
    ..We used ATGL(-/-) mice to determine the role of PEDF in regulating lipid and glucose metabolism...
  36. ncbi Novel CDNF/MANF family of neurotrophic factors
    Päivi Lindholm
    Institute of Biotechnology, Viikinkaari 9, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Neurobiol 70:360-71. 2010
    ..Future studies will reveal the receptors and mode of action of these novel factors, which are potential therapeutic proteins for the treatment of PD...
  37. ncbi Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis
    O W Howell
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health Imperial College Faculty of Medicine, Charing Cross Hospital Campus, London, UK
    Brain 129:3173-85. 2006
    ....
  38. ncbi Neurotrophin signaling through the p75 neurotrophin receptor
    Philippe P Roux
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Que, Canada H3A 2B4
    Prog Neurobiol 67:203-33. 2002
    ....
  39. pmc Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression
    Charlotta Dagnell
    Department of Medicine Solna, Respiratory Medicine Unit, Karolinska Institutet Karolinska University Hospital Solna, Stockholm, Sweden
    Respir Res 11:156. 2010
    ..However, less is known about levels of BDNF and NT-3, and moreover, knowledge in the cellular sources of neurotrophins and the distribution of the corresponding neurotrophin receptors in airway tissue in sarcoidosis is lacking...
  40. ncbi Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    A Tomac
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Nature 373:335-9. 1995
    ..We conclude that intracerebral GDNF administration exerts both protective and reparative effects on the nigrostriatal dopamine system, which may have implications for the development of new treatment strategies for Parkinson's disease...
  41. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
    ..These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness...
  42. pmc Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation
    Joseph Tcherkezian
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 141:632-44. 2010
    ....
  43. pmc The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
    R Klein
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Cell 66:395-403. 1991
    ..Finally, 125I-NT-3 binds to NIH 3T3 cells expressing gp145trkB; binding can be competed by NT-3 and BDNF but not by NGF. These findings indicate that gp145trkB may function as a neurotrophic receptor for BDNF and NT-3...
  44. ncbi Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury
    Raghu Kempegowda Tadagavadi
    Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 185:3750-8. 2010
    ..Our studies demonstrate that netrin-1 acting through UNC5B receptor reduces renal ischemia-reperfusion injury and its associated renal inflammation...
  45. pmc Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation
    Kazuo Nakamura
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 170:2159-70. 2007
    ..Our present study suggests that substitution of PEDF may be a novel therapeutic strategy for restenosis after balloon angioplasty...
  46. ncbi Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    Elia J Duh
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Maumenee 809, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 43:821-9. 2002
    ....
  47. ncbi In vitro and in vivo biological activity of PEDF against a range of tumors
    Matthew L Broadhead
    University of Melbourne, St Vincent s Hospital, Department of Orthopaedics and Surgery, L3, Daly Wing, 35 Victoria Pde, Fitzroy 3065, Vic, Australia
    Expert Opin Ther Targets 13:1429-38. 2009
    ..These direct and indirect effects of PEDF have been examined in vitro and in vivo for a range of malignancies...
  48. pmc Anti-tumor effect of adenovirus-mediated gene transfer of pigment epithelium-derived factor on mouse B16-F10 melanoma
    Li Ping Yang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Clinical Medicine School, Sichuan University, Chengdu, Sichuan, PR China
    J Exp Clin Cancer Res 28:75. 2009
    ..As a potent inhibitor of tumor angiogenesis, pigment epithelium-derived factor (PEDF) has recently been studied and used as an anticancer agent in several tumor models...
  49. ncbi Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury
    T K Ali
    Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Diabetologia 54:657-68. 2011
    ..We sought to elucidate how oxidative stress impairs homeostasis of nerve growth factor (NGF) and its precursor, proform of NGF (proNGF), to cause neurovascular dysfunction in the eye of diabetic patients...
  50. pmc Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    M Hofer
    Max Planck Institute for Psychiatry, Department of Neurochemistry, Martinsried, FRG
    EMBO J 9:2459-64. 1990
    ..The BDNF mRNA was localized by in situ hybridization in hippocampal neurons (pyramidal and granule cells). These data suggest that BDNF may play an important role in the CNS for a wide variety of adult neurons...
  51. ncbi The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization
    Wei Fan
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane QLD 4059, Australia
    Differentiation 81:181-91. 2011
    ....
  52. pmc Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site
    Hua Liu
    Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287 8984, USA
    Proc Natl Acad Sci U S A 101:6605-10. 2004
    ..Furthermore, PEDF may represent a superior therapeutic approach to sepsis-associated hypotension, nephrotic syndrome, and other sight-threatening and life-threatening diseases resulting from excessive vascular permeability...
  53. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    ..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
  54. ncbi Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration
    Takayuki Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502
    J Neurosci 22:9228-36. 2002
    ..These observations suggest that microglia regulate the microglia-Müller glia-photoreceptor network that serves as a trophic factor-controlling system during retinal degeneration...
  55. pmc Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors
    Pouneh Kermani
    Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 115:653-63. 2005
    ....
  56. ncbi Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment
    Jessica E Malberg
    Wyeth Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 28:1562-71. 2003
    ..These findings demonstrate that exposure to IS, which results in a state of behavioral despair, decreases hippocampal cell proliferation and that this effect can be reversed by fluoxetine treatment...
  57. ncbi PEDF: anti-angiogenic guardian of ocular function
    Noel Bouck
    Dept of Microbiology Immunology and Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 310 East Superior Street, Chicago, IL 60611, USA
    Trends Mol Med 8:330-4. 2002
    ..The molecular basis for this delicate control of endothelial cells is beginning to be understood and strategies to test the ability of PEDF to ameliorate or prevent vessel damage in the eye are developing rapidly...
  58. ncbi Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer
    Stephanie Filleur
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 65:5144-52. 2005
    ..Our results map active regions for the two PEDF functions, signaling via distinct receptors, identify candidate peptides, and provide their mechanism of action for future development of PEDF-based tumor therapies...
  59. ncbi Molecular mechanisms of axon guidance
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 298:1959-64. 2002
    ..With such regulatory mechanisms in place, a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring...
  60. ncbi The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 89:581-92. 2004
    ..These data, coupled with our previous report that proNGF is the major form of NGF in the CNS, suggest that proNGF could be responsible for much of the biological activity normally attributed to mature NGF in vivo...
  61. ncbi The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
    D Soppet
    Molecular Embryology Section, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Cell 65:895-903. 1991
    ..Thus, the trk family of receptors are likely to be important signal transducers of NGF-related trophic signals in the formation and maintenance of neuronal circuits...
  62. ncbi Focus on Molecules: Pigment epithelium-derived factor (PEDF)
    S Patricia Becerra
    NIH NEI, 7 Memorial Drive, Room 304, Building 7, Bethesda, MD 20892, USA
    Exp Eye Res 82:739-40. 2006
  63. pmc The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase
    Fabien Llambi
    Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Lyon, France
    EMBO J 24:1192-201. 2005
    ..Thus, the pair netrin-1/UNC5H2 may regulate cell fate by controlling the proapoptotic kinase activity of DAP-kinase...
  64. ncbi Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model
    Kiryo Wakabayashi
    Department of Neurology, Shimane University School of Medicine, Izumo, Japan
    J Neurosci Res 88:1017-25. 2010
    ..Intravenously transplanted human MSCs induced functional improvement, reduced infarct volume, and neuroprotection in ischemic rats, possibly by providing IGF-1 and inducing VEGF, EGF, and bFGF neurotrophic factors in host brain...
  65. pmc Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells
    Fernanda I Staquicini
    David H Koch Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:2903-8. 2009
    ..Our findings present a unique molecular mechanism mediating astrocytic/neuronal crosstalk that regulates ongoing neurogenesis in the adult olfactory system...
  66. pmc Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B
    Esma Lejmi
    Institut National de la Sante et de la Recherche Medicale, Unité 689 Institut des Vaisseaux et du Sang, F 75010 Paris, France
    Proc Natl Acad Sci U S A 105:12491-6. 2008
    ..Moreover, Netrin-4 overexpression delayed tumor angiogenesis in a model of s.c. xenograft. We propose that Netrin-4 acts as an antiangiogenic factor through binding to neogenin and recruitment of Unc5B...
  67. ncbi Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation
    Shan Lu
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Toxicology 279:189-95. 2011
    ....
  68. ncbi Interference with netrin-1 and tumor cell death in non-small cell lung cancer
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    J Natl Cancer Inst 101:237-47. 2009
    ..The status of netrin-1 and its receptors in non-small cell lung cancer (NSCLC) was unknown...
  69. ncbi CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease
    Ronald J Mandel
    University of Florida, College of Medicine, Department of Neuroscience, PO Box 100244, Gainesville, FL 32610, USA
    Curr Opin Mol Ther 12:240-7. 2010
    ..CERE-110 has passed phase I clinical testing and a multicenter phase II clinical trial has commenced. CERE-110 is a promising candidate for the treatment of AD...
  70. ncbi S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
    ..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression...
  71. pmc Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis
    Bruno Larrivee
    Institut National de la Santé et de la Recherche Médicale U833, F 75005 Paris, France
    Genes Dev 21:2433-47. 2007
    ..These data show that UNC5B activation inhibits sprouting angiogenesis, thus identifying UNC5B as a potential anti-angiogenic target...
  72. ncbi BAX is required for neuronal death after trophic factor deprivation and during development
    T L Deckwerth
    Department of Molecular Biology and Pharmacology, Howard Hughes Medical Institute Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 17:401-11. 1996
    ..Bax-deficient superior cervical ganglia and facial nuclei possessed increased numbers of neurons. Our observations demonstrate that trophic factor deprivation-induced death of sympathetic and motor neurons depends on Bax...
  73. ncbi GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    L F Lin
    Synergen, Inc, Boulder, CO 80301
    Science 260:1130-2. 1993
    ..GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons...
  74. pmc A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions
    Hui Yuan Hou
    Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Mol Ther 18:1837-45. 2010
    ..These results suggest that MSCs contribute to CNV and could serve as delivery vehicles of antiangiogenic agents for the treatment of a range of CNV-associated diseases...
  75. ncbi The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome
    H Worthmann
    Department of Neurology, Medical School of Hannover, Hannover, Germany
    Cerebrovasc Dis 30:85-92. 2010
    ..The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage...
  76. ncbi Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia
    Luigi Notari
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 0607, USA
    Invest Ophthalmol Vis Sci 46:2736-47. 2005
    ..Because hypoxia and VEGF regulate matrix metalloproteinases (MMPs), their effects on PEDF proteolysis were explored...
  77. ncbi Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury
    Tae Y Yune
    Age Related and Brain Diseases Research Center, Kyung Hee University, Seoul 130 701, Korea
    J Neurosci 27:7751-61. 2007
    ..Finally, minocycline treatment inhibited oligodendrocyte death and improved functional recovery after SCI. These results suggest that minocycline may represent a potential therapeutic agent for acute SCI in humans...
  78. ncbi Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice
    Ryunosuke Hase
    Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Clin Cancer Res 11:8737-44. 2005
    ..The purpose of this study was to investigate whether PEDF gene is a potent tumor suppressor and a potential candidate for cancer gene therapy...
  79. pmc DSCAM functions as a netrin receptor in commissural axon pathfinding
    Guofa Liu
    Department of Neurology and Robert H Lurie Comprehensive Cancer Center, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:2951-6. 2009
    ..Our data suggest previously unexpected complexity in receptors that mediate vertebrate netrin signaling...
  80. pmc Netrin-1 inhibits leukocyte migration in vitro and in vivo
    Ngoc P Ly
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 1414, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 102:14729-34. 2005
    ..These data suggest that endothelial expression of netrin-1 may inhibit basal cell migration into tissues and that its down-regulation with the onset of sepsis/inflammation may facilitate leukocyte recruitment...
  81. ncbi The yin and yang of neurotrophin action
    Bai Lu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892 3714, USA
    Nat Rev Neurosci 6:603-14. 2005
    ..New insights into the 'yin and yang' of neurotrophin activity have profound implications for our understanding of the role of neurotrophins in a wide range of cellular processes...
  82. ncbi Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy
    Sarah X Zhang
    Department of Medicine, Department of Cell Biology, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK, USA
    J Mol Endocrinol 37:1-12. 2006
    ..The decrease in PEDF levels in the retina is at least partially responsible for the increase in VEGF expression and subsequent vascular leakage and neovascularization in diabetes...
  83. ncbi Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial
    Peter A Campochiaro
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Gene Ther 17:167-76. 2006
    ..11 in patients with neovascular AMD should be performed...
  84. ncbi S100B and NSE serum levels in obstructive sleep apnea syndrome
    Carla W Braga
    Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Sleep Med 7:431-5. 2006
    ..In the present work we measured the serum levels of S100B and NSE in order to evaluate the deleterious effects of OSAS to the brain...
  85. pmc Neurotrophic factors in Alzheimer's disease: role of axonal transport
    K Schindowski
    Institut National de la Santé et de la Research Médicale U837, Universite Lille 2, Lille Cedex, France
    Genes Brain Behav 7:43-56. 2008
    ....
  86. ncbi Towards non invasive nerve growth factor therapies for Alzheimer's disease
    Antonino Cattaneo
    European Brain Research Institute EBRI Rita Levi Montalcini Foundation, Rome, Italy
    J Alzheimers Dis 15:255-83. 2008
    ....
  87. ncbi Potential inflammatory biomarkers in Alzheimer's disease
    Robert E Mrak
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Alzheimers Dis 8:369-75. 2005
    ....
  88. pmc Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway
    Zhi Zheng
    Department of Ophthalmology, First People s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China
    Diabetes 58:954-64. 2009
    ....
  89. pmc Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease
    Scott D Olson
    Stem Cell Program and Institute for Regenerative Cures, University of California Davis Health Systems, 2921 Stockton Blvd, Room 1300, Sacramento, CA 95817, USA
    Mol Neurobiol 45:87-98. 2012
    ..The current data in support of applying MSC-based cellular therapies to the treatment of Huntington's disease is discussed...
  90. ncbi A spatio-temporal analysis of motoneuron survival, axonal regeneration and neurotrophic factor expression after lumbar ventral root avulsion and implantation
    R Eggers
    Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Exp Neurol 223:207-20. 2010
    ..These findings have important implications for future strategies to promote long-distance regeneration through distal, chronically denervated peripheral nerves...
  91. ncbi The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment
    Sabine Lindquist
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Mult Scler 17:851-66. 2011
    ..In multiple sclerosis inflammation is primarily injurious to the central nervous system, but its therapeutic suppression might inhibit repair-promoting factors...
  92. ncbi Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells
    S Famulla
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Int J Obes (Lond) 35:762-72. 2011
    ..The aim of this study was to investigate the regulation and autocrine function of PEDF in human adipocytes and to determine its paracrine effects on human skeletal muscle cells (hSkMC) and human smooth muscle cells (hSMC)...
  93. pmc Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
    K R Jones
    Howard Hughes Medical Institute University of California, San Francisco School of Medicine 94143
    Cell 76:989-99. 1994
    ..In contrast with mice lacking the BDNF receptor TrkB, motor neurons appear normal in the BDNF mutant...
  94. ncbi Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone
    Celia Andreu-Agullo
    Departamento de Biología Celular and CIBER en Enfermedades Neurodegenerativas, Universidad de Valencia, Burjassot, Spain
    Nat Neurosci 12:1514-23. 2009
    ..Our data provide a basis for stemness regulation in vascular niches and indicate that Notch and PEDF cooperate to regulate self-renewal...
  95. ncbi Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis
    Johan Undén
    Department of Anaesthesia and Intensive Care, Halmstad Regional Hospital, Halmstad, Sweden
    J Head Trauma Rehabil 25:228-40. 2010
    ..To determine whether low levels of S100B in serum can predict normal computed tomography (CT) findings after minor head injury (MHI) in adults...
  96. ncbi Pigment epithelium-derived factor inhibits glioma cell growth in vitro and in vivo
    Tao Zhang
    Center of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Central Urumqi Road, Shanghai 200040, China
    Life Sci 81:1256-63. 2007
    ..PEDF activation can be a novel approach for future therapeutic purposes against gliomas...
  97. ncbi Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma
    Kojiro Matsumoto
    First Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Japan
    Hepatology 40:252-9. 2004
    ..Reduction of serum PEDF concentration associated with the development of chronic liver diseases may contribute to the progression of HCC. In addition, gene therapy using PEDF may provide an efficient treatment for HCC...
  98. pmc S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    J Biol Chem 286:7214-26. 2011
    ..These results suggests that S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE-dependent regulation of several inflammation-related events including activation and migration of microglia...
  99. ncbi Pigment epithelium-derived factor inhibits advanced glycation end-products-induced cytotoxicity in retinal pericytes
    S Sheikpranbabu
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University Kalasalingam Academy of Research and Education, Krishnankoil 626126, Anand Nagar, Tamilnadu, India
    Diabetes Metab 37:505-11. 2011
    ..This study investigated the effects of pigment epithelium-derived factor (PEDF) on advanced glycation end-product (AGE)-induced cytotoxicity in porcine retinal pericytes and the signalling mechanism involved...
  100. ncbi Anti-chondrosarcoma effects of PEDF mediated via molecules important to apoptosis, cell cycling, adhesion and invasion
    Mei Lin Tan
    Department of Orthopaedics, St Vincent s Hospital Melbourne, Vic, Australia
    Biochem Biophys Res Commun 398:613-8. 2010
    ..These findings seminally indicate that PEDF may have potential as an anti-cancer agent against chondrosarcoma...
  101. ncbi Effects of head and extracranial injuries on serum protein S100B levels in trauma patients
    Olli Savola
    Department of Neurology, Oulu University Hospital, Oulu, Finland
    J Trauma 56:1229-34; discussion 1234. 2004
    ..Serum protein S100B determinations have been recently suggested as markers of traumatic brain injury. However, little is known about the effects of extracranial injuries on S100B levels in trauma patients...

Research Grants62

  1. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ....
  2. Spatial Considerations in Neuronal Survival Signals
    Rosalind A Segal; Fiscal Year: 2013
    ..In these studies, we will ask how levels of Bclw in axons are regulated by Nerve growth factors. Bclw has been shown to be protective against b-amyloid in Alzheimers'and to protect animals from ..
  3. BIOLOGY OF ALZHEIMER AMYLOID IN NEURONS
    Gunnar K Gouras; Fiscal Year: 2010
    ..important membrane receptors, and for their transport along axons of vital cargo proteins, including nerve growth factors and their receptors...
  4. Effects of TrkB Activation on Abnormalities in Neocortical FS Interneurons
    DAVID ALLAN PRINCE; Fiscal Year: 2013
    ....
  5. The Role of Novel Angiogenic Signals in Post-Stroke Neurogenesis
    ANDREW JOHN BRUMM; Fiscal Year: 2013
    ..As there are currently no treatments to promote post-stroke functional recovery, such signaling systems may be valuable targets for neural repair in human stroke. ..
  6. REORGANIZATION AFTER BRAIN INJURY
    JAIME VILLABLANCA; Fiscal Year: 1990
    ..and controlled behavioral studies are meager; (2) although neuronal-promoting roles of gangliosides and nerve growth factors are well established, proof of their efficacy to restore brain damage in a higher mammal, in vivo model is ..
  7. ROLE OF INSULIN-LIKE GROWTH FACTORS IN THE PNS
    Eva Feldman; Fiscal Year: 1993
    ..Our long term goal is to understand how the insulin-like growth factors regulate growth in the nervous system and to bridge the gap between receptor activation, signal induction and neurite outgrowth...
  8. TOTAL SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    JIN CHA; Fiscal Year: 2007
    ..binding; and erinacines (Xll and XlII), the cyathane-type diterpenoids that possess potent stimulating activity of nerve growth factors; and mitomycin alkaloids [e.g., mitomycin C (XlVc)] which are clinically important antitumor agents.
  9. NERVE GROWTH FACTOR ACTION ON ADULT CNS NEURONS IN VIVO
    SILVIO VARON; Fiscal Year: 1993
    ....
  10. CARDIOVASCULAR BIOLOGY AND ATHEROSCLEROSIS
    KATHERINE HAJJAR; Fiscal Year: 2009
    ..of platelet adhesion;nitric oxide biology;cellular transformation by viruses;relationship of nerve growth factors and neurotrophins to vascular cell proliferation and differentiation;the role of smooth muscle proteins in ..
  11. Cortical Catheters
    Martin Brady; Fiscal Year: 2004
    ..has been the delivery of neurotrophic factors into the affected regions and, specifically, the infusion of nerve growth factors into carefully targeted areas...
  12. CHARACTERIZATION OF CHOLINERGIC NEUROTROPHIC FACTOR
    BRADLEY WISE; Fiscal Year: 1991
    ..Potential interactions between the purified brain membrane-associated factor and other known neurotrophic factors, such as nerve growth factor, will be investigated...
  13. MECHANISMS OF CELLULAR RESPONSES TO NERVE GROWTH FACTOR
    Steven Green; Fiscal Year: 1990
    ..The identification, the function, and the role in NGF signal transduction of neuronal proteins possessing such activities will be explored in these studies...
  14. FIBROBLAST GROWTH FACTORS IN THE AGING BRAIN
    SETH FINKLESTEIN; Fiscal Year: 1993
    ..These studies will provide novel information concerning the role of FGFs in the aging brain, and may have important therapeutic implications for aging and AD...
  15. Transcriptional Elements Active in Developmental and Regenerative Axon Growth
    Ava Udvadia; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. FOURTH INTERNATIONAL SYMPOSIUM ON NEURAL TRANSPLANTATION
    JEFFREY ROSENSTEIN; Fiscal Year: 1992
    ..This would insure both timely and detailed dissemination of information to the neuroscience community. In addition, Travel Awards for students and postdoctorals with emphasis on underrepresented minorities will be available...
  17. NONVIRAL VECTORS FOR GENE TRANSFER IN THE AGED RAT BRAIN
    Keyi Yang; Fiscal Year: 1999
    Recent studies have shown that administration of exogenous nerve growth factors (NGF) can attenuate cholinergic neuronal deficits and improve spatial memory in aged rats...
  18. Erythropoietin therapy for Parkinson's disease
    Marie Csete; Fiscal Year: 2003
    ..However, recent evidence suggests that EPO is a more potent neurotrophic factor than the traditional nerve growth factors such as GDNF in a wide range of clinical situations...
  19. Neuronal Apoptosis Induced by DNA Damage
    Italo Mocchetti; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Neurotrophic factors and HIV-mediated neuronal injury
    Italo Mocchetti; Fiscal Year: 2008
    ....
  21. Neuronal transport of gp120
    Italo Mocchetti; Fiscal Year: 2005
    ..abstract_text> ..
  22. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
    ..Data from this proposal may help elucidate the therapeutic efficacy of antidepressants in affective disorders. [unreadable] [unreadable]..
  23. PTP identity and inhibition for nigrostriatal protection
    Theo Hagg; Fiscal Year: 2003
    ..These studies will increase our understanding of how dopaminergic neurons function, validate our new treatment approach and provide us with research tools to improve it for application to Parkinson's disease. ..
  24. Gene Expression Profile of Antidepressants
    Ronald Duman; Fiscal Year: 2003
    ..abstract_text> ..
  25. ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAIN
    Ronald Duman; Fiscal Year: 2004
    ..Finally, studies to identify the isoforms of cAMP phophodiesterase (PDE4) that catalyzes the breakdown of cAMP are proposed, including regulation of PDE4 isoforms by antidepressant treatment and development of PDE4 null mutant mice. ..
  26. Profiling Gene Expression in Major Depression
    Ronald Duman; Fiscal Year: 2008
    ..abstract_text> ..
  27. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTH
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003
    ..abstract_text> ..
  29. NEUROTROPHIN REGULATION IN THE SPINAL CORD
    Fernando Gomez Pinilla; Fiscal Year: 2003
    ..abstract_text> ..
  30. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  31. Production of dopamine neurons from human embryonic stem cells
    KAI SONNTAG; Fiscal Year: 2008
    ..The use of this new technology in cell replacement paradigms for PD could be a major step towards hESC-based therapies for chronic neurodegenerative disorders. ..
  32. TRAINING IN AGE-RELATED NEURODEGENERATIVE DISEASES
    Elliott Mufson; Fiscal Year: 2008
    ..Finally the program will provide a broad-base of knowledge on neurodegenerative disorders as well as other instruction important for enhancing the interpersonal and professional skills of our trainees. ..
  33. Brain Aging & Gene Expression Patterns Using Microarrays
    Carl Cotman; Fiscal Year: 2007
    ..Once an initial primary paper is published the overall data will be made available to the field via NACC for various investigators to analyze for the testing their own hypotheses. ..
  34. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2008
    ..abstract_text> ..
  35. Katzir Conference on Life and Death in the Nervous System
    Moses Chao; Fiscal Year: 2008
    ..The meetings have been a very effective means of stimulating new research and attracting new scientists to the field. [unreadable] [unreadable] [unreadable]..
  36. PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORS
    Fernando Gomez Pinilla; Fiscal Year: 2002
    ..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins. ..
  37. A Genetic Approach to Study the p75 Neurotrophin Receptor
    Wilma J Friedman; Fiscal Year: 2010
    ....
  38. MECHANISMS OF PATHOLOGICAL NEURITIC & SOMAL DEGENERATION
    Carl Cotman; Fiscal Year: 2002
    ..The studies proposed in this application will provide new and basic biological findings potentially relevant to a wide array of normal and pathological events involving synaptic remodeling and neurite degeneration. ..
  39. REGULATION OF MASTICATORY MUSCLE FIBER PHENOTYPE
    ARTHUR ENGLISH; Fiscal Year: 2002
    ..The new knowledge generated will impact significantly several areas of clinical dentistry. ..
  40. NEUROTROPHINS AND CARDIOGENESIS
    Barbara Hempstead; Fiscal Year: 2002
    ....
  41. AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS
    Y S Prakash; Fiscal Year: 2001
    ....
  42. IMPROVED CELL COUNTING USING THE OPTICAL DISECTOR
    CHRISTOPHER VON BARTHELD; Fiscal Year: 2004
    ....
  43. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  44. ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    Carl Cotman; Fiscal Year: 2004
    ..Data from the proposed experiments will provide an initial characterization of how a simple, widely practiced activity-exercise-regulates expression of BDNF, a molecule increasingly recognized for its critical role in brain function. ..
  45. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  46. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  47. APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    Carl Cotman; Fiscal Year: 2004
    ..Together, these experiments may provide support for a mechanism (s) accounting for some of the well-known changes in brain aging and AD, including reduced activity dependent plasticity, synaptic integrity and neuronal survival. ..
  48. Induction of immune tolerance to FasL-expressing ES cell
    Kai Christian Sonntag; Fiscal Year: 2005
    ..Results from this work will have implications for immunomodulation of ES cell grafts in both allogeneic and xenogeneic transplantation settings. ..
  49. Gordon Conference on Neurotrophic Factors (2003,2005)
    Barbara Hempstead; Fiscal Year: 2005
    ..Hempstead and Y.-A. Barde) to profile new and young investigators as speakers in this Conference and for them to have a leadership role at this meeting. ..
  50. ABeta Immunization in Aging
    Carl Cotman; Fiscal Year: 2005
    ..Overall, this project should provide unique insight into the efficacy of immunization with fibrillar Abeta and have direct implications for the design of human clinical trials. ..
  51. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. Neuronal mRNA transport & local translation analysis
    Jeffery Twiss; Fiscal Year: 2004
    ..g., spinal motor neurons) and whether we can utilize exogenous agents to increase local axonal protein synthesis for expediting axonal regeneration. ..
  53. CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    Carl Cotman; Fiscal Year: 2005
    ..Overall, this project should provide unique insight into the role of oxidative damage and subsequent molecular cascades on the progression of brain aging and cognitive decline. ..
  54. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  55. The ER Stress Response and ATF6 Activation in the Heart
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007
    ..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
  56. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  57. Proteoglycan degradation and functional recovery after peripheral nerve injury
    ARTHUR ENGLISH; Fiscal Year: 2007
    ..This proposal seeks to evaluate a technology for medical treatment of peripheral nerve injuries which, if successful, could have an important impact on a relatively large group of under-treated patients. [unreadable] [unreadable]..