vitamins

Summary

Summary: A general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. They may be water-soluble or fat-soluble. (Dorland, 28th ed)

Top Publications

  1. ncbi A single dose of vitamin D enhances immunity to mycobacteria
    Adrian R Martineau
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
    Am J Respir Crit Care Med 176:208-13. 2007
  2. ncbi The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins
    Jorn Kalinowski
    Institut für Genomforschung, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    J Biotechnol 104:5-25. 2003
  3. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
  4. pmc Vitamin effects on the immune system: vitamins A and D take centre stage
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 8:685-98. 2008
  5. ncbi Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000
    Kathy Radimer
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Am J Epidemiol 160:339-49. 2004
  6. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
  7. ncbi Risk assessment for vitamin D
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC 20036 5114, USA
    Am J Clin Nutr 85:6-18. 2007
  8. ncbi Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial
    R Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    J Intern Med 264:599-609. 2008
  9. pmc Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 308:1751-60. 2012
  10. ncbi Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities
    Sibel Ulker
    Department of Medicine, Institute of Clinical Science Block B, Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Hypertension 41:534-9. 2003

Detail Information

Publications356 found, 100 shown here

  1. ncbi A single dose of vitamin D enhances immunity to mycobacteria
    Adrian R Martineau
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
    Am J Respir Crit Care Med 176:208-13. 2007
    ..Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed...
  2. ncbi The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins
    Jorn Kalinowski
    Institut für Genomforschung, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    J Biotechnol 104:5-25. 2003
    ..As an example for biotechnological application the complete genome sequence was used to reconstruct the metabolic flow of carbon into a number of industrially important products derived from the amino acid L-aspartate...
  3. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  4. pmc Vitamin effects on the immune system: vitamins A and D take centre stage
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 8:685-98. 2008
    b>Vitamins are essential constituents of our diet that have long been known to influence the immune system...
  5. ncbi Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000
    Kathy Radimer
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Am J Epidemiol 160:339-49. 2004
    ..Vitamin C, vitamin E, B-complex vitamins, calcium, and calcium-containing antacids were taken by more than 5% of adults...
  6. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
    Randomized trials have largely failed to support an effect of antioxidant vitamins on the risk of cardiovascular disease (CVD)...
  7. ncbi Risk assessment for vitamin D
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC 20036 5114, USA
    Am J Clin Nutr 85:6-18. 2007
    ..Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL...
  8. ncbi Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial
    R Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    J Intern Med 264:599-609. 2008
    ....
  9. pmc Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 308:1751-60. 2012
    ..Observational studies have shown inconsistent associations between regular multivitamin use and CVD, with no long-term clinical trials of multivitamin use...
  10. ncbi Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities
    Sibel Ulker
    Department of Medicine, Institute of Clinical Science Block B, Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Hypertension 41:534-9. 2003
    Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress...
  11. ncbi Vitamin D(3) is more potent than vitamin D(2) in humans
    Robert P Heaney
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E447-52. 2011
    Current unitage for the calciferols suggests that equimolar quantities of vitamins D(2) (D2) and D(3) (D3) are biologically equivalent. Published studies yield mixed results.
  12. ncbi Can oxidative damage be treated nutritionally?
    Mette M Berger
    Surgical ICU, Soins Intensifs Chirurgicaux et Centre des Brûlés, CHUV BH08 660, CH 1011 Lausanne, Switzerland
    Clin Nutr 24:172-83. 2005
    ..The beneficial effects have been attributed to the reduction of oxidative damage caused by the normal or excessive free radical production. The papers aims at collecting evidence of successful supplementation strategies...
  13. ncbi Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 179:2060-3. 2007
    ..These data demonstrate that cathelicidin is required for the 1,25D(3)-triggered antimicrobial activity against intracellular M. tuberculosis...
  14. ncbi Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials
    Philippe Autier
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Arch Intern Med 167:1730-7. 2007
    ..We examined the risk of dying from any cause in subjects who participated in randomized trials testing the impact of vitamin D supplementation (ergocalciferol [vitamin D(2)] or cholecalciferol [vitamin D(3)]) on any health condition...
  15. ncbi Contribution of selected vitamins and trace elements to immune function
    Eva S Wintergerst
    Bayer Consumer Care Ltd, Basel, Switzerland
    Ann Nutr Metab 51:301-23. 2007
    Adequate intakes of vitamins and trace elements are required for the immune system to function efficiently...
  16. pmc A novel class of modular transporters for vitamins in prokaryotes
    Dmitry A Rodionov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 191:42-51. 2009
    ..The shared use of energy-coupling modules was experimentally confirmed for folate, thiamine, and riboflavin transporters. We propose the name energy-coupling factor transporters for the new class of membrane transporters...
  17. pmc Vitamin D and risk of cognitive decline in elderly persons
    David J Llewellyn
    Public Health and Epidemiology Group, Peninsula Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, England
    Arch Intern Med 170:1135-41. 2010
    ..To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia...
  18. pmc Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism
    Rebecca J Schmidt
    Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, USA
    Epidemiology 22:476-85. 2011
    ..Causes of autism are unknown. Associations with maternal nutritional factors and their interactions with gene variants have not been reported...
  19. pmc Antioxidant vitamins and their use in preventing cardiovascular disease
    Dan Farbstein
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Molecules 15:8098-110. 2010
    ..the discovery that oxidative stress plays a pivotal role in the development and progression of atherosclerosis, vitamins C and E, along with other antioxidants, were studied as potential therapies for the disease...
  20. ncbi Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Copenhagen, Denmark
    Lancet 364:1219-28. 2004
    ..Oxidative stress can cause cancer. Our aim was to establish whether antioxidant supplements reduce the incidence of gastrointestinal cancer and mortality...
  21. ncbi Multivitamin-multimineral supplements: who uses them?
    Cheryl L Rock
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0901, USA
    Am J Clin Nutr 85:277S-279S. 2007
    ..Thus, MVMM use contributes a considerable proportion of nutrient intakes in the United States and may contribute to risk of excessive intakes...
  22. ncbi Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial
    Christian Wejse
    Infectious Disease Research Unit, Aarhus University Hospital, Skejby, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Am J Respir Crit Care Med 179:843-50. 2009
    ..Vitamin D has been shown to be involved in the host immune response toward Mycobacterium tuberculosis...
  23. ncbi Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses
    Silvia Maggini
    Bayer Consumer Care Ltd, Peter Merian Strasse 84, P O Box, 4002 Basel, Switzerland
    Br J Nutr 98:S29-35. 2007
    ..This paper summarises the roles of selected vitamins and trace elements in immune function...
  24. pmc Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial
    You Lin Qiao
    Cancer Institute, Chinese Academy of Medical Sciences, Beijing, Peoples Republic of China
    J Natl Cancer Inst 101:507-18. 2009
    ..Here, we present 10-year follow-up after the end of active intervention...
  25. ncbi Role of lipids, lipoproteins and vitamins in women with breast cancer
    G Ray
    Department of Biosciences, Jamia Millia Islamia, 110025, New Delhi, India
    Clin Biochem 34:71-6. 2001
    ..Lipids, lipoproteins and antioxidative vitamins have been associated with the risk of breast cancer...
  26. ncbi Dietary assessment methods for micronutrient intake: a systematic review on vitamins
    Patricia Henríquez-Sánchez
    Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
    Br J Nutr 102:S10-37. 2009
    ..of the present study was to define how to identify dietary intake validation studies in adults pertaining to vitamins. After establishing a search strategy, we conducted a MEDLINE and EMBASE literature review...
  27. ncbi Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial
    David Osrin
    International Perinatal Care Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Lancet 365:955-62. 2005
    ..We tested the hypotheses that antenatal multiple micronutrient supplementation would increase infant birthweight and gestational duration...
  28. pmc Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) study
    Jessie A Satia
    Departments of Nutrition and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Epidemiol 169:815-28. 2009
    ..retinol, vitamin A, lutein, and lycopene with lung cancer risk among participants, aged 50-76 years, in the VITamins And Lifestyle (VITAL) cohort Study in Washington State...
  29. pmc Algae need their vitamins
    Martin T Croft
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Eukaryot Cell 5:1175-83. 2006
  30. ncbi Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis
    Rajiv Chowdhury
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Epidemiol 27:581-91. 2012
    ..Conversely, higher circulating calcium concentration is associated with an increased risk of cerebrovascular disease...
  31. pmc Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer
    Srilatha Swami
    Department of Medicine Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Endocrinology 153:2576-87. 2012
    ..These preclinical data demonstrate the potential utility of dietary vitamin D(3) supplementation in cancer prevention and therapy...
  32. ncbi The effects of multivitamins on cognitive performance: a systematic review and meta-analysis
    Natalie A Grima
    Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia
    J Alzheimers Dis 29:561-9. 2012
    ..In conclusion, multivitamins were found to enhance immediate free recall memory but no other cognitive domains...
  33. ncbi Dietary intakes of antioxidant vitamins and mortality from cardiovascular disease: the Japan Collaborative Cohort Study (JACC) study
    Yoshimi Kubota
    Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka fu 565 0871, Japan
    Stroke 42:1665-72. 2011
    ..We investigated the relation of dietary vitamins A, E, and C intake with mortality from cardiovascular disease for Japanese men and women.
  34. ncbi The effect of supplemental vitamins and minerals on the development of prostate cancer: a systematic review and meta-analysis
    Julie Stratton
    Primary Healthcare Research Unit, Agnes Cowan Hostel, St John s Newfoundland, A1B 3V6, Canada
    Fam Pract 28:243-52. 2011
    Vitamin supplementation is used for many purposes with mainly alleged benefits. One of these is the use of various vitamins for the prevention of prostate cancer.
  35. ncbi Antioxidant vitamins in atherosclerosis--animal experiments and clinical studies
    Seckin Ozkanlar
    Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey
    Adv Clin Exp Med 21:115-23. 2012
    ..Prolonged use of vitamins in the diet has not yet been recommended in human beings...
  36. pmc Gamma-carboxylation of osteocalcin and insulin resistance in older men and women
    M Kyla Shea
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 90:1230-5. 2009
    ..In vitro and animal studies indicate that high uncarboxylated osteocalcin is associated with reduced insulin resistance. However, associations between osteocalcin and measures of insulin resistance in humans are less clear...
  37. pmc Vitamin C: update on physiology and pharmacology
    J Mandl
    Department of Medical Chemistry, Molecular Biology and Patobiochemistry, Semmelweis University Budapest, Budapest, Hungary
    Br J Pharmacol 157:1097-110. 2009
    ..The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for ascorbate in the treatment of various diseases...
  38. ncbi High-dose oral vitamin D3 supplementation in the elderly
    C J Bacon
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Osteoporos Int 20:1407-15. 2009
    ..With baseline 25OHD > 50 nmol/L, vitamin D supplementation does not reduce PTH levels...
  39. ncbi Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes mellitus
    Monica A L Gabbay
    Diabetes Center of Endocrinology Division, Department ofMedicine, Sao Paulo Federal University, Sao Paulo, SP, Brazil
    Arch Pediatr Adolesc Med 166:601-7. 2012
    ....
  40. ncbi Socioeconomic differences among Australian adults in consumption of fruit and vegetables and intakes of vitamins A, C and folate
    K Giskes
    Centre for Public Health Research, School of Public Health, Queensland University of Technology, Queensland, Australia
    J Hum Nutr Diet 15:375-85; discussion 387-90. 2002
    ....
  41. ncbi Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E
    Fu Yu
    School of Life Sciences, Lanzhou University, Lanzhou 730000, People s Republic of China
    Exp Toxicol Pathol 59:415-23. 2008
    ..effects of organophosphorus insecticide chlorpyrifos on mouse retina in vivo and protection of combination of vitamins C and E were reported...
  42. pmc Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy
    Takahiro Kataoka
    Graduate School of Health Sciences, Okayama University, 5 1 Shikata cho 2 chome, Kita ku, Okayama Shi, Okayama 700 8558, Japan
    J Radiat Res 53:830-9. 2012
    ..It has also been reported that antioxidant vitamins can inhibit CCl(4)-induced hepatopathy...
  43. ncbi Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients
    Maria Martinesi
    Department of Biochemical Sciences, University of Florence, Florence, Italy
    Inflamm Bowel Dis 14:597-604. 2008
    ..Our aim was to verify whether 2 vitamin D derivatives, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and EB 1089, could induce cell apoptosis and affect cell-cell interaction by regulating adhesion molecule levels...
  44. ncbi Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery
    Alison R Scaife
    Department of Environmental and Occupational Medicine, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Nutr 95:771-8. 2006
    The aim of the present study was to test the hypothesis that maternal intake of antioxidant vitamins is associated with maternal and cord plasma levels at delivery...
  45. pmc Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial
    Christine Stabell Benn
    Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark
    BMJ 340:c1101. 2010
    ..To investigate the effect of vitamin A supplementation and BCG vaccination at birth in low birthweight neonates...
  46. ncbi Vitamins and cardiovascular disease
    S Honarbakhsh
    Department of Clinical Pharmacology, Faculty of Medicine, NHLI, ICL, St Mary s Hospital, London W2 1NY, UK
    Br J Nutr 101:1113-31. 2009
    ..A beneficial role for vitamins in CVD has long been explored but the data are still inconsistent...
  47. ncbi A safe strategy for addition of vitamins and minerals to foods
    S E Rasmussen
    Danish Institute for Food and Veterinary Research, 19 Mørkhøj Bygade, 2860, Søborg, Denmark
    Eur J Nutr 45:123-35. 2006
    Addition of vitamins and minerals to foods must be done without health risk to any consumer group...
  48. ncbi Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case-control study and randomised clinical trial
    Marie Kjærgaard
    Medical Clinic, University Hospital of North Norway N 9038 Tromsø, Norway
    Br J Psychiatry 201:360-8. 2012
    ..To compare depressive symptoms in participants with low and high serum 25-hydroxyvitamin D (25(OH)D) levels and to examine whether supplementation with vitamin D(3) would improve symptoms in those with low serum 25(OH)D levels...
  49. ncbi Antioxidant vitamins and cardiovascular disease
    Jorge M Nunez-Cordoba
    Department of Preventive Medicine and Public Health, Medical School, University of Navarra Clinic, Irunlarrea 1, 31008 Pamplona, Spain
    Curr Top Med Chem 11:1861-9. 2011
    ..The present manuscript gives a brief overview of the relationship between natural antioxidants (specially vitamin C, vitamin E and beta-carotene) intake and the risk of CVD...
  50. ncbi Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
    Haruhiko Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, and Department of Gastroenterology and Hepatology, Kanto Central Hospital, Tokyo, Japan
    Hepatology 54:532-40. 2011
    ..150 (95% confidence interval: 0.843-1.570, one-sided; P=0.811) between the placebo and combined active-drug groups, and the study was discontinued in March 2007...
  51. ncbi The survival advantage for haemodialysis patients taking vitamin D is questioned: findings from the Dialysis Outcomes and Practice Patterns Study
    Francesca Tentori
    Department of Internal Medicine, Arbor Research Collaborative for Health, University of Michigan Health System, Ann Arbor, MI 48103, USA
    Nephrol Dial Transplant 24:963-72. 2009
    ....
  52. ncbi Clinical pharmacology and therapeutic use of antioxidant vitamins
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, Santiago, Chile
    Fundam Clin Pharmacol 21:111-27. 2007
    ..Therefore, supplements of vitamins C and E were applied through protocols aimed to prevent diseases such as atherosclerosis, preeclampsia or ..
  53. ncbi Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials
    Leanne Harling
    Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary s Hospital, London W2 1NY, UK
    Heart 97:1636-42. 2011
    ..This study aims to provide a quantitative summary of the current evidence surrounding antioxidant vitamins and POAF prevention.
  54. ncbi The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension and cardiovascular disease
    Mark C Houston
    Hypertension Institute, 4230 Harding Road, Suite 400, Nashville, TN 37205, USA
    Ther Adv Cardiovasc Dis 4:165-83. 2010
    ..Optimal nutrition, nutraceuticals, vitamins, antioxidants, minerals, weight loss, exercise, smoking cessation and moderate restriction of alcohol and ..
  55. pmc Vitamin and mineral supplement use by children and adolescents in the 1999-2004 National Health and Nutrition Examination Survey: relationship with nutrition, food security, physical activity, and health care access
    Ulfat Shaikh
    University of California Davis School of Medicine, 2516 Stockton Blvd, Sacramento, CA 95817, USA
    Arch Pediatr Adolesc Med 163:150-7. 2009
    ..To determine if vitamin and mineral supplement use among children and adolescents in the United States is associated with nutrition, food security, physical activity, and health care access...
  56. pmc Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis
    Agustin Conde-Agudelo
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 204:503.e1-12. 2011
    To determine whether supplementation with vitamins C and E during pregnancy reduces the risk of preeclampsia and other adverse maternal and perinatal outcomes.
  57. ncbi Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide
    Mahdi Goudarzvand
    Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Cell Mol Neurobiol 30:289-99. 2010
    ..Antioxidant vitamins D and E are suggested for patients suffering from neurodegenerative diseases like MS, while their mechanisms of ..
  58. ncbi Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Ophthalmol 122:883-92. 2004
    To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM).
  59. ncbi Vitamin D: a pleiotropic hormone
    Annemieke Verstuyf
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 78:140-5. 2010
    ....
  60. ncbi Oral calcitriol for reduction of proteinuria in patients with IgA nephropathy: a randomized controlled trial
    Li Jun Liu
    Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, PR China
    Am J Kidney Dis 59:67-74. 2012
    ..Vitamin D has shown efficacy in the reduction of proteinuria in patients with chronic kidney disease. This study aimed to determine the effect of calcitriol on urinary protein excretion in patients with immunoglobulin A (IgA) nephropathy...
  61. ncbi Putting cardiovascular disease and vitamin D insufficiency into perspective
    Armin Zittermann
    Department of Cardio Thoracic Surgery, Heart Center North Rhine Westfalia, Ruhr University of Bochum, Bad Oeynhausen, Germany
    Br J Nutr 94:483-92. 2005
    ..However, more controlled clinical trials are needed to investigate whether optimal oral vitamin D supplementation is able to reduce CVD morbidity and mortality...
  62. pmc Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
    Shaista Naqvi
    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain
    Proc Natl Acad Sci U S A 106:7762-7. 2009
    ..way to increase the vitamin content of staple crops, but thus far it has only been possible to enhance individual vitamins. We created elite inbred South African transgenic corn plants in which the levels of 3 vitamins were increased ..
  63. ncbi Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis
    Rebecca Gilbert
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Cancer Causes Control 22:319-40. 2011
    ..We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D) concentrations) with prostate cancer...
  64. ncbi Dietary supplements in a national survey: Prevalence of use and reports of adverse events
    Babgaleh B Timbo
    Epidemiology Team, Office of Scientific Analysis and Support, College Park, MD 20740, USA
    J Am Diet Assoc 106:1966-74. 2006
    ..To examine information collected from the 2002 Health and Diet Survey regarding the use dietary supplements and self-reported health problems that the survey participants believed were related to dietary supplements...
  65. ncbi Vitamins and minerals: a model for safe addition to foods
    Albert Flynn
    University College Cork, Department of Food and Nutritional Sciences, Cork, Ireland
    Eur J Nutr 42:118-30. 2003
    Significant subgroups in most European populations have intakes below nationally recommended levels for several vitamins, minerals and trace elements, placing individuals at risk of suboptimal intake of important vitamins and minerals...
  66. pmc CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant
    Matthew G McDonald
    Department of Medicinal Chemistry, University of Washington, Seattle, 98195, USA
    Mol Pharmacol 75:1337-46. 2009
    ..Therefore, patients with the rs2108622 polymorphism are likely to have elevated hepatic levels of VK1, necessitating a higher warfarin dose to elicit the same anticoagulant response...
  67. ncbi Meta-analysis: vitamin D compounds in chronic kidney disease
    Suetonia C Palmer
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Ann Intern Med 147:840-53. 2007
    ..Vitamin D compounds are widely used to prevent and treat secondary hyperparathyroidism...
  68. ncbi Antifatigue effects of coenzyme Q10 during physical fatigue
    Kei Mizuno
    Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nutrition 24:293-9. 2008
    ..This study examined the effects of coenzyme Q10 administration on physical fatigue...
  69. ncbi Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  70. ncbi Innate immunity to mycobacteria: vitamin D and autophagy
    Eun Kyeong Jo
    Department of Microbiology, Chungnam National University School of Medicine, Jungku, Daejeon, Korea
    Cell Microbiol 12:1026-35. 2010
    ..Integrated dialog between autophagy and innate immunity may contribute to adequate host immune defences against mycobacterial infection...
  71. ncbi Vitamins and perinatal outcomes among HIV-negative women in Tanzania
    Wafaie W Fawzi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 356:1423-31. 2007
    ..Prematurity and low birth weight are associated with high perinatal and infant mortality, especially in developing countries. Maternal micronutrient deficiencies may contribute to these adverse outcomes...
  72. ncbi Vitamin D for cancer prevention: global perspective
    Cedric F Garland
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA
    Ann Epidemiol 19:468-83. 2009
    ..Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers...
  73. ncbi Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa)
    Anne Lise Brantsaeter
    Division of Environmental Medicine, Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Ann Nutr Metab 51:146-54. 2007
    ..The aim of the present study was to investigate the relation between reported use and biomarkers in supplement and non-supplement users and to validate self-reported intake of dietary supplements in mid pregnancy...
  74. ncbi Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review
    Christine M Velicer
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    J Clin Oncol 26:665-73. 2008
    ....
  75. ncbi Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
    Sarah Cockayne
    York Trials Unit, Department of Health Sciences, University of York, York YO10 5DD, England
    Arch Intern Med 166:1256-61. 2006
    ..Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture...
  76. ncbi Nutritional consequences of adjustable gastric banding and gastric bypass: a 1-year prospective study
    Muriel Coupaye
    Explorations Fonctionnelles, Centre de Référence de l Obésité, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92700, Colombes, France
    Obes Surg 19:56-65. 2009
    ..However, no study has compared the prevalence of nutritional deficiencies after these two bariatric procedures. WE PROSPECTIVELY COMPARED: To prospectively compare the prevalence of nutritional deficiencies after AGB and GBP...
  77. ncbi Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Arhus C, Denmark
    Annu Rev Nutr 21:407-28. 2001
    ..Here we summarize and discuss the structural, genetic, and functional aspects of megalin and cubilin, with emphasis on their function as receptors for uptake of protein-associated vitamins, lipids, and hormones.
  78. ncbi Elucidating biosynthetic pathways for vitamins and cofactors
    Michael E Webb
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Nat Prod Rep 24:988-1008. 2007
    The elucidation of the pathways to the water-soluble vitamins and cofactors has provided many biochemical and chemical challenges...
  79. ncbi The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial
    D Carroll
    School of Sport and Exercise Sciences, University of Birmingham, UK
    Psychopharmacology (Berl) 150:220-5. 2000
    ..Vitamin and mineral supplements may be associated with improved psychological status...
  80. ncbi Serum vitamins and heavy metals in blood and urine, and the correlations among them in Parkinson's disease patients in China
    Tetsuhito Fukushima
    Department of Hygiene and Preventive Medicine, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Neuroepidemiology 36:240-4. 2011
    Some heavy metals are suspected to be pathogenic and some vitamins protective against Parkinson's disease (PD), and the interaction between heavy metals and vitamins could be associated with the pathophysiology of PD.
  81. pmc Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production
    Peter Belenky
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 6:e19710. 2011
    ..Here we show that both nicotinamide riboside and nicotinic acid are not only vitamins but are also exported metabolites...
  82. ncbi Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children
    Isabelle Aeberli
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 84:748-55. 2006
    ..Dietary factors, such as fatty acids and antioxidants, potentially modulate the association between adiposity and subclinical inflammation, but few data are available in children...
  83. ncbi A randomized trial of multivitamin supplements and HIV disease progression and mortality
    Wafaie W Fawzi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:23-32. 2004
    ..Results from observational studies suggest that micronutrient status is a determinant of the progression of human immunodeficiency virus (HIV) disease...
  84. pmc Long-term use of supplemental vitamins and minerals does not reduce the risk of urothelial cell carcinoma of the bladder in the VITamins And Lifestyle study
    James M Hotaling
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98103, USA
    J Urol 185:1210-5. 2011
    ..We used the prospective VITamins And Lifestyle cohort to examine the association of all commonly taken vitamin and mineral supplements as well as ..
  85. ncbi Sequential determination of fat- and water-soluble vitamins in Rhodiola imbricata root from trans-Himalaya with rapid resolution liquid chromatography/tandem mass spectrometry
    Amol B Tayade
    Defence Institute of High Altitude Research, Defence Research and Development Organisation, Leh Ladakh, Jammu and Kashmir 194101, India
    Anal Chim Acta 789:65-73. 2013
    A rapid method was developed to determine both types of vitamins in Rhodiola imbricata root for the accurate quantification of free vitamin forms...
  86. ncbi Vitamins and cognition: what is the evidence?
    David O Kennedy
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, UK
    Drugs 71:1957-71. 2011
    ..Several indirect strands of evidence suggest that increasing levels of vitamins may improve brain function...
  87. ncbi High-dose supplements of vitamins C and E, low-dose multivitamins, and the risk of age-related cataract: a population-based prospective cohort study of men
    Jinjin Zheng Selin
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 177:548-55. 2013
    We examined the associations of high-dose supplements of vitamins C and E and low-dose multivitamins with the risk of age-related cataract among 31,120 Swedish men, aged 45-79 years, in a population-based prospective cohort...
  88. pmc Macronutrients, vitamins and minerals intake and risk of esophageal squamous cell carcinoma: a case-control study in Iran
    Mahsa Jessri
    Human Nutrition Division, Department of Agricultural, Food and Nutritional Sciences, Edmonton Clinic Health Academy, University of Alberta, Edmonton, Canada
    Nutr J 10:137. 2011
    ..The aim of this study was to evaluate the effect of macronutrients, vitamins and minerals on the risk of ESCC.
  89. ncbi Roles of vitamin A status and retinoids in glucose and fatty acid metabolism
    Shi Zhao
    The Diabetes Center, Wuhan Central Hospital, Wuhan, Hubei 430014, China
    Biochem Cell Biol 90:142-52. 2012
    ..Future research projects relevant to the VA's roles in metabolic diseases are also discussed...
  90. ncbi Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk
    Sang Ah Lee
    Kangwon National University School of Medicine, Gangwon Do, Korea
    Nutr Cancer 62:1087-94. 2010
    ..state of oxidative stress with high levels of reactive oxygen species, which are removed by cellular antioxidant vitamins. We investigated the independent and combined effect of antioxidant vitamins intake and the ATM genotype or ..
  91. ncbi Vitamins and neural and cognitive developmental outcomes in children
    David Benton
    Department of Psychology, University of Swansea, Singleton Park, Swansea SA2 8PP, UK
    Proc Nutr Soc 71:14-26. 2012
    ..There are data with a range of vitamins, from animal studies and human studies in developing countries, suggesting that a clinical deficiency during the ..
  92. pmc γ-Tocotrienol attenuates TNF-α-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes
    Tetsuro Matsunaga
    AJINOMOTO Integrative Research for Advanced Dieting, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Mol Med Rep 5:905-9. 2012
    ..Our results suggest that γ-tocotrienol may improve obesity-related functional abnormalities in adipocytes by attenuating NF-κB activation and the expression of inflammatory adipokines...
  93. pmc Vitamin D supplementation and depression in the women's health initiative calcium and vitamin D trial
    Elizabeth R Bertone-Johnson
    Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, 409 Arnold House, 715 North Pleasant Street, Amherst, MA 01003 9304, USA
    Am J Epidemiol 176:1-13. 2012
    ..Additional trials testing higher doses of vitamin D are needed to determine whether this nutrient may help prevent or treat depression...
  94. ncbi Position of the American Dietetic Association: nutrient supplementation
    Melissa Ventura Marra
    Private Practice, Boynton Beach, FL, USA
    J Am Diet Assoc 109:2073-85. 2009
    ....
  95. ncbi Antiproliferative and apoptosis-inducing effects of lipophilic vitamins on human melanoma A375 cells in vitro
    Mai Ishibashi
    Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    Biol Pharm Bull 35:10-7. 2012
    The effects of six lipophilic vitamins: tretinoin (ATRA), vitamin D(3) (VD(3)), VE, VK(1), VK(3), and VK(5) on cell proliferation and apoptosis in human A375 melanoma cells were investigated...
  96. pmc Multivitamin use in pregnant and nonpregnant women: results from the Behavioral Risk Factor Surveillance System
    Kevin M Sullivan
    Department of Epidemiology, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA
    Public Health Rep 124:384-90. 2009
    ..S. We examined multivitamin use among pregnant and nonpregnant women of childbearing age, in relation to socioeconomic factors, demographic data, health behaviors, and health status...
  97. ncbi How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol
    George Wolf
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA
    Nutr Rev 64:295-9. 2006
    ..Excess a-tocopherol taken in supplements causes a reduction of gamma-tocopherol concentration in plasma. The biochemical mechanism of this effect, which is important to human nutrition, has recently been elucidated...
  98. ncbi Strengths and limitations of current epidemiologic studies: vitamin D as a modifier of colon and prostate cancer risk
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Nutr Rev 65:S77-9. 2007
  99. ncbi Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: A randomized controlled trial
    Helen Macpherson
    Centre for Human Psychopharmacology, NICM Collaborative Centre for Neurocognition, Swinburne University of Technology, 427 451 Burwood Road, Hawthorn, Melbourne, Vic, 3122, Australia
    Psychopharmacology (Berl) 220:351-65. 2012
    ..This randomized, double-blind, placebo-controlled trial was conducted to investigate the effects of 16 weeks multivitamin supplementation (Swisse Women's 50+ Ultivite ®) on cognition in elderly women...
  100. ncbi Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension
    Mark C Houston
    Department of Medicine, Division of General Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Cardiovasc Dis 47:396-449. 2005
    ..Optimal nutrition, nutraceuticals, vitamins, antioxidants, minerals, weight loss, exercise, smoking cessation, and moderate restriction of alcohol and ..
  101. ncbi Vitamins at physiological levels cause oxidation to the DNA nucleoside deoxyguanosine and to DNA--alone or in synergism with metals
    Therese Bergström
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE 141 83 Huddinge, Sweden
    Mutagenesis 27:511-7. 2012
    b>Vitamins with antioxidant properties have the ability to act as pro-oxidants, inducing oxidative damage and oxidative stress as opposed to preventing it...

Research Grants77

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..At every visit, participants will answer questions about general health and current medications (including any vitamins or supplements). They will also have a full eye exam and a 20- to 40-minute test...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..At every visit, participants will answer questions about general health and current medications (including any vitamins or supplements). They will also have a full eye exam and a 20- to 40-minute test...
  3. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..dosed feed on bone osteopenia and osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other toxicological effects in Sprague-Dawley rats...
  4. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..dosed feed on bone osteopenia and osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other toxicological effects in Sprague-Dawley rats...
  5. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..the transfusions, that cannot be effectively eliminated from the body, a contrast with other required metals and vitamins. The protection against malaria conferred by SCD and THL mutations increases the numbers of carriers...
  6. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..role of methyl groups - S-adenosylmethionine, S-adenosylhomocysteine, methionine, choline, homocysteine, folate, vitamins B6 and B12 in the development of liver cancer;(4) to assess the role of genetic polymorphisms influencing methyl ..
  7. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..We will examine effect modification by intake of antioxidant vitamins (E and C) and the genetic polymorphisms...
  8. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..physiological detergents that facilitate absorption, transport, distribution and disposal of steroids, nutrients, vitamins, metabolites and xenobiotics, but also are signaling molecules that activate nuclear receptors and cell signaling ..
  9. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamins and their metabolites are essential for a number of physiological processes including regulating the immune systems...
  10. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..However, the previous use of antioxidant supplements in clinical trials (e.g., Vitamins E and C, beta-carotene) has yielded disappointing and controversial results...
  11. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..bicarbonate, urea nitrogen, and creatinine), selected micronutrients (ferritin for iron status, folic acid, vitamins A, B12, and E, and selenium), and inflammatory markers (C-reactive protein and 1-1-acid glycoprotein) before and ..
  12. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..We will examine effect modification by intake of antioxidant vitamins (E and C) and cytokine polymorphisms...
  13. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..Plasma antioxidants (glutathione, vitamins A and E, 1 and 2-carotenes, zinc and selenium) will also be determined...
  14. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..and [unreadable]-carotene, cryptoxanthin, cysteine, folate, lutein, lycopene, oleic acid, pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group metabolism - betaine, choline, folate, ..
  15. Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPI
    Jan Frederik Stevens; Fiscal Year: 2010
    ..of great benefit to quantitation and characterization of lipid peroxidation products and metabolites, as well as vitamins and their metabolites in biological samples including human plasma or urine, cultured cells and mitochondria...
  16. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..circulation of bile acids is essential for processes such as intestinal absorption of dietary fats and vitamins, cholesterol homeostasis, bile flow, and biliary lipid secretion, these data suggest that Ost?-Ost? also ..
  17. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..if the associations between pollutants and age-related diseases are modified by dietary intake of antioxidants (vitamins C and E, carotenoids, and cruciferous vegetables) and omega-3 fatty acids...
  18. Tumor -Targeting Chemotherapeutic Agents
    Iwao Ojima; Fiscal Year: 2013
    ..A rapidly growing tumor requires various nutrients and vitamins. Therefore, tumor cells overexpress many tumor-specific receptors, which can be used as targets to deliver ..
  19. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2013
    ..Our specific aims are: (1) To determine whether maternal intake of B vitamins-- folate, vitamins B12 and B6--are associated with aberrant methylation and loss of imprinting of insulin-like ..
  20. Symbiotic Rickettsia Species as a Model System for the Study of Folate Biosynthes
    Jianmin Zhong; Fiscal Year: 2012
    ..endosymbionts have been shown to contribute to their hosts'fitness by supplying them with essential vitamins and amino acids. The metabolic basis for the symbiotic relationship of endosymbionts in ticks has been unknown...
  21. Genetic Risk for Orofacial Clefts in the Folate/Homocysteine Pathway
    NICHOLAS MARINI; Fiscal Year: 2013
    ..One of the most promising clues to the causes of orofacial clefts is that women who use vitamins containing folic acid in early pregnancy are at much lower risk for cleft-affected pregnancies...
  22. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2012
    ..Several dietary factors including folate, alcohol, methionine, riboflavin, vitamins B6 and B12, choline, and betaine mediate or facilitate one-carbon metabolism pathway...
  23. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
    ..Bile acids play an invaluable role in the intestinal absorption of food-derived lipids and lipid-soluble vitamins and drugs...
  24. Intestinal Triacylglycerol Metabolism and Energy Balance
    Chi Liang Eric Yen; Fiscal Year: 2013
    ..is essential for the assimilation of high-energy substrates, essential fatty acids, and fat-soluble nutrients and vitamins. It also is a central player in obesity and associated metabolic disorders...
  25. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..The kidney plays an important role in the activation of the form of vitamin D contained in vitamins. This study will compare the standard vitamin D type contained in vitamins to that which is the equivalent form ..
  26. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2009
    ..detergents that generate bile flow and facilitate intestine absorption and transport of lipids, nutrients and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and a ..
  27. Structure/Function of Steroid Transforming AKR's
    Trevor M Penning; Fiscal Year: 2011
    ..The production of bile-acids is essential for normal liver function and absorption of fats and fat-soluble vitamins from the G.I. tract...
  28. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    John Y L Chiang; Fiscal Year: 2013
    ..detergents that generate bile flow and facilitate intestine absorption and transport of lipids, nutrients and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and a ..
  29. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
    ..Several epidemiologic studies have reported that maternal use of vitamins during pregnancy reduces the risk of NB...
  30. Phase 2 Study of High Dose DHA for the Treatment of X-Linked Retinitis Pigmentosa
    Dennis R Hoffman; Fiscal Year: 2013
    ..analysis (every 6 months) and biosafety measures (annually) assess RBC fatty acids, platelet aggregation, plasma vitamins A and E, plasma antioxidant capacity, plasma malonyldialdehyde, plasma oxidized low-density lipoprotein (LDL), ..
  31. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..that program subsets of skin migratory DC to the induction of T regs, 2) the determination of the role of Vitamins, acting on DCs and/or T cells in vivo, for the generation of T regs, and 3) the evaluation of the suppressive ..
  32. Caring for Those Who Share: Mitigating Iron Deficiency in Regular Blood Donors
    Alan E Mast; Fiscal Year: 2013
    ..In Specific Aim 2 we will provide donors with a 60-day supply of multiple vitamins formulated with 38, 19 or 0 mg of elemental iron to take following each blood donation...
  33. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ..g., ?-3 fatt acids and antioxidant micronutrients (e.g., vitamins C and E and flavonoids)] ascertained using a triad approach incorporating a food frequency questionnaire (FFQ), ..
  34. Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention
    Emily White; Fiscal Year: 2013
    ..In 1999, Dr. Emily White was awarded funding for the VITamins And Lifestyle (VITAL) study, a prospective cohort study of dietary supplement use and cancer risk...
  35. Plant-based diets and risk of cancer
    Gary E Fraser; Fiscal Year: 2013
    ..Next to focus on nutrients, phytochemicals, vitamins and food groups that differ between these dietary patterns, including red meat, tomatoes, dairy foods, ..
  36. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    ..These studies have a significant impact on human health, since they aim at reducing the incidence of fetal malformations associated with an abnormal maternal intake of micronutrients, such as vitamins.
  37. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2012
    ..about the mechanisms linking one-carbon metabolism to colorectal carcinogenesis, including about the influence of vitamins B6 and B12, and global DNA methylation and the impact of folic-acid fortification;and 3) provide valuable ..
  38. Cohort Study of Glucosamine and Chondroitin Supplement Use and Cancer Risk
    Emily White; Fiscal Year: 2012
    ..The VITamins And Lifestyle (VITAL) study is a prospective study which targeted supplement users in recruitment...
  39. Genetic Approaches to Lipid Metabolism
    John E Cronan; Fiscal Year: 2013
    ..Further investigations of the mechanisms of synthesis of the fatty acid-derived vitamins, biotin and lipoic acid, which are essential enzyme cofactors in all three domains of life, are proposed...
  40. The Effect of Genetic Diversity on Mechanism-Based Inactivation of CYP2D6
    Laura L Furge; Fiscal Year: 2013
    ..P450 enzymes (CYPs) in humans are a family of heme-containing enzymes involved in metabolism of steroids, vitamins, eiconsanoids, and xenobiotics such as drugs, complex plant alkaloids, carcinogens, and other small molecules...
  41. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Robert Strunk; Fiscal Year: 2013
    ..them to one of two treatment arms of a 4-year clinical trial: 4000 IU of Vitamin D in addition to usual prenatal vitamins, n=435;and usual prenatal vitamins alone, n=435...
  42. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Scott T Weiss; Fiscal Year: 2013
    ..them to one of two treatment arms of a 4-year clinical trial: 4000 IU of Vitamin D in addition to usual prenatal vitamins, n=435;and usual prenatal vitamins alone, n=435...
  43. ADENOSINE AND ANTIOXIDANT ENZYMES
    Vickram Ramkumar; Fiscal Year: 1999
    ..Px) and glutathione reductase (GR) and nonenzymatic antioxidants such as vitamins A, C and E and reduced glutathione...
  44. Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
    Andrea Baccarelli; Fiscal Year: 2013
    ..Our goal is to determine whether a pharmacological intervention with methyl-donors (i.e., folic acid, Vitamins B6 &B12, betaine, methionine, and choline) can avert this DNA methylation loss and mitigate the ..
  45. Study of Soy Isoflavones in Asthma (SOYA)
    Robert A Wise; Fiscal Year: 2013
    ..Yet, epidemiological and interventional studies designed to identify key nutrients or antioxidant vitamins that may be responsible for the increase in disease severity have produced inconsistent results...
  46. Study of Soy Isoflavones in Asthma (SOYA)
    Lewis J Smith; Fiscal Year: 2013
    ..Yet, epidemiological and interventional studies designed to identify key nutrients or antioxidant vitamins that may be responsible for the increase in disease severity have produced inconsistent results...
  47. IMMUNOBIOLOGY OF AGING
    CHARLES GARRISON FATHMAN; Fiscal Year: 2010
    ..The registry will contain demographic data, race/ethnicity, prescribed medications, over the counter medications, vitamins, alternative therapies, physical function questionnaire, alternative contact person, and HIPPA release...
  48. Epigenetic Events and Colorectal Cancer Epidemiology
    Shuji Ogino; Fiscal Year: 2013
    ..Accumulating evidence suggests that dietary factors (e.g., alcohol and one-carbon nutrients such as B vitamins) may affect cellular epigenetic status...
  49. Multi-vitamins, HAART and HIV/AIDS in Uganda
    Wafaie W Fawzi; Fiscal Year: 2012
    ..double-blind, placebo- controlled, randomized trial of the same high-dose multivitamin supplements (containing B-vitamins, C, and E) to determine their efficacy in slowing disease progression, indicated by increased CD4 count, weight ..
  50. The Perinatal Pharmacology of the Nuclear Receptor
    Wen Xie; Fiscal Year: 2013
    ..of bile acids, likely due to the suppression of Cyp7a1;3) Perinatal dietary supplement of bile acids and/or vitamins relived the hepatotoxicity and partial lethality o the transgenic pups;4) There was a material effect on the ..
  51. Exploring Interactions between Folate and Environmental Risk Factors for Autism
    REBECCA JEAN SCHMIDT; Fiscal Year: 2013
    ..we found that mothers of children with autism were significantly less likely to report having taken prenatal vitamins around conception than mothers of typically developing (TD) children...
  52. ASPirin in Reducing Events in the Elderly
    JOHN JAMES MCNEIL; Fiscal Year: 2013
    ..g., HRT, COX-2 inhibitors and anti-oxidant vitamins, has emphasized the need to formally establish safety and efficacy before such therapies enter routine practice.
  53. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010
    ..Based upon data that folate, other B vitamins, and methionine can influence endothelial function either directly or through effects on circulating homocysteine ..
  54. Salmonella polymicrobial interactions
    BRIAN M AHMER; Fiscal Year: 2012
    ..applicant): Salmonella polymicrobial interactions Abstract The normal microbiota provide essential nutrients and vitamins to the host and also make it very difficult for pathogenic microbes to colonize...
  55. Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    JOHN H contact GRIFFIN; Fiscal Year: 2010
    ..in hypothesis-generating research, we hypothesize that imbalances of certain plasma metabolites including lipids, vitamins, hormones, saccharides, amino acids, nucleotides, and/or organic acids are biomarkers for VTE risk...
  56. Risk Factors for Hearing Loss
    Gary C Curhan; Fiscal Year: 2013
    ..In addition to noise, factors potentially associated with risk of hearing loss include analgesics, vitamins, alcohol, menopausal status and postmenopausal hormone use...
  57. Impact of chronic caloric restriction on resident progenitor cells in the heart
    KURT SAUPE; Fiscal Year: 2009
    ..can be slowed and lifespan extended by placing animals on a diet that is very low in calories and enriched in vitamins and minerals. How this type of diet slows aging and prevents age-associated diseases is not known...
  58. Surgical wound repair: effect of metabolic memory on neuro-endothelial responses
    NICOLE SIMONE GIBRAN; Fiscal Year: 2013
    ..Our proposal to evaluate whether antioxidants vitamins E and C reverse effects of glucose and fatty acids on endothelial cell and neural progenitor cell responses will ..
  59. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..We will also examine the effects of vitamins C and E (inhibitors of nitrosation) on the relations between nitrate/nitrite intake and nitrosatable drugs and ..
  60. Methyl Donor Pathway Genetics in the Development of Orofacial Clefts
    JASPER D RINE; Fiscal Year: 2010
    ..One of the most promising clues to the causes of orofacial clefts is that women who use vitamins containing folic acid in early pregnancy are at much lower risk for cleft-affected pregnancies...
  61. Medical Food Cocktail for Alzheimer's Disease
    CURT H HENDRIX; Fiscal Year: 2010
    ..The Akeso Health Sciences (Akeso) medical food cocktail is composed of standardized herbal extracts, vitamins, and minerals that are demonstrated in the basic science and clinical medical literature to impact the ..
  62. Nutrition and Oral Clefts in Asia: Planning Grant
    Ronald G Munger; Fiscal Year: 2010
    ..study the following hypotheses will be tested: (1) maternal biomarkers related to 1-CM including folate, zinc, vitamins B6 and B12, and homocysteine are each independently associated with risk of oral clefts;(2) 1-CM biomarkers ..
  63. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..Study [WACS]) Trial, funded by NHLBI, is a randomized, double-blind, placebo-controlled trial of antioxidant vitamins (vitamin C, vitamin E, and beta-carotene) and B vitamins (folic acid, vitamin B6, and vitamin B12) for the ..
  64. DOES ATHEROSCLEROSIS REGRESS WITH THERAPY FOR LOW HDLC?
    Bruce Brown; Fiscal Year: 2000
    ..that a 15 mg/dl rise in HDL cholesterol would reduce CAD incidence and mortality by 30-70% and that antioxidant vitamins E, C, and Beta-carotene might reduce CAD events and atherogenesis...
  65. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..In the available aliquots of heated and unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) ..
  66. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..The investigators suggest that this is due in part to an effect of diet on a individual's antioxidant status. Vitamins and minerals contribute to the oxidative defense system because: (1) they are antioxidants (vitamins E, C and B-..
  67. NEONATAL PARENTERAL NUTRITION AND HEPATIC DYSFUNCTION
    Jatinder Bhatia; Fiscal Year: 1990
    ..ambient light in neonatal nurseries, or when the solutions are in prolonged contact with photosensitizers such as vitamins. The proposed studies will test the hypothesis that parenteral nutrients (amino acids, glucose and vitamins) are ..
  68. VITAMIN B2 AND B6 IN VERY LOW BIRTH WEIGHT INFANTS
    LARRY SWIFT; Fiscal Year: 1992
    ..toxicity are unlikely because of inherent complications associated with extreme immaturity, blood levels of the vitamins are felt to be the most appropriate method to determine efficacy of vitamin dosages...
  69. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): We have shown that supplementation with vitamins B, C, and E during pregnancy and lactation to HIV-infected women is related to lower rates of breastfeeding transmission among women in ..
  70. Protection against radiation-induced damage to intestinal nutrient transport
    Roger Howell; Fiscal Year: 2009
    ..There is considerable evidence to suggest that naturally occurring antioxidant vitamins may provide a long window of protection against effects caused by these exposure conditions...
  71. BIOLOGIC ACTIVITY OF BETA-CAROTENE METABOLITES
    Robert Russell; Fiscal Year: 2005
    ..to investigate possible protective effects of a rational combination of linked antioxidants (beta-carotene, vitamins C and E) against cigarette smoke-induced lung lesions in the ferret model...
  72. Maternal transfer of protection from allergic gastrointestinal disease
    Lynn Puddington; Fiscal Year: 2009
    ..of the major functions of breast milk and breast milk macrophages is to deliver dietary lipids and fat-soluble vitamins (e.g. vitamin A [retinol] and its metabolites) to nursing offspring...
  73. LOCALIZED VITAMIN DEFICIENCIES AND RISK FOR LUNG CANCER
    Chandrika Piyathilake; Fiscal Year: 2001
    ..Although there are some reports on the epithelial lining fluid (ELF) levels of vitamins C and E, and their accumulation by alveolar macrophages (AM) of smokers, none of these studies has measured a ..
  74. NUCLEAR HORMONE ACTION--ROLE OF UBIQUITIN PATHWAYS
    Zafar Nawaz; Fiscal Year: 2003
    Steroids, vitamins, retinoids, and thyroid hormones exert profound effects on cell growth, development, differentiation, homeostasis and tumorigenesis through their cognate nuclear receptors which make up a superfamily of structurally ..
  75. BREATH ETHANE, BIOMARKER OF VITAMIN A AND E DEFICIENCY
    Kathleen Schwarz; Fiscal Year: 1993
    Deficiencies of vitamins A and E may adversely affect both the outcome of pregnancy and the health of premature infants, in whom repeated serum measurements are problematic...
  76. VITAMIN E ATHEROSCLEROSIS PREVENTION STUDY
    HOWARD HODIS; Fiscal Year: 1999
    ..A large body of data from animal and epidemiological studies provide convincing evidence that antioxidant vitamins can reduce formation and progression of atherosclerosis...
  77. RECYCLING DEFECTS OF COVALENTLY-BOUND VITAMINS
    Barry Wolf; Fiscal Year: 1991
    ..treatable inherited metabolic disorders and have given new insight into the nutritional role of the various vitamins. We have recently demonstrated that one such disease, late-onset biotin-responsive multiple carboxylase ..