interleukin 18

Summary

Summary: Cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK cells and CTLs, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Top Publications

  1. ncbi Interleukin-18
    J Alastair Gracie
    Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    J Leukoc Biol 73:213-24. 2003
  2. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
  3. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
  4. ncbi IL-1, IL-18, and IL-33 families of cytokines
    William P Arend
    Division of Rheumatology, University of Colorado Denver, School of Medicine, Denver, CO, USA
    Immunol Rev 223:20-38. 2008
  5. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
  6. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
  7. ncbi Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
  8. ncbi Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
  9. ncbi The inflammasomes: guardians of the body
    Fabio Martinon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 27:229-65. 2009
  10. pmc Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis
    Norbert Gerdes
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 195:245-57. 2002

Detail Information

Publications362 found, 100 shown here

  1. ncbi Interleukin-18
    J Alastair Gracie
    Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    J Leukoc Biol 73:213-24. 2003
    ..Subsequent cloning of human IL-18 cDNA revealed 65% homology with murine IL-18 [(3) ] and showed that both contain an unusual leader sequence consisting of 35 amino acids at their N terminus...
  2. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
    ..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways...
  3. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..IGIF may be involved in the development of Th1 cells and also in mechanisms of tissue injury in inflammatory reactions...
  4. ncbi IL-1, IL-18, and IL-33 families of cytokines
    William P Arend
    Division of Rheumatology, University of Colorado Denver, School of Medicine, Denver, CO, USA
    Immunol Rev 223:20-38. 2008
    ..IL-18 provides an important link between the innate and adaptive immune responses. Newly described IL-33 binds to the orphan IL-1 family receptor T1/ST2 and stimulates T-helper 2 responses as well as mast cells...
  5. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity...
  6. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc...
  7. ncbi Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
    ..Therefore, the functions of IL-18 in vivo are very heterogeneous and complicated. In principle, IL-18 enhances the IL-12-driven Th1 immune responses, but it can also stimulate Th2 immune responses in the absence of IL-12...
  8. ncbi Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
    ..This is likely to affect how we design effective, but safe, adjuvants in the future...
  9. ncbi The inflammasomes: guardians of the body
    Fabio Martinon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 27:229-65. 2009
    ..In this review, we discuss the role of NLRs, and in particular the inflammasomes, in the recognition of microbial and danger components and the role they play in health and disease...
  10. pmc Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis
    Norbert Gerdes
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 195:245-57. 2002
    ....
  11. ncbi Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:31240-8. 2005
    ..The possibility that altered IL-18 expression in the eye of DBA/2J mice initiates and/or amplifies the pathogenesis of pigmentary glaucoma requires further investigation...
  12. ncbi Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)
    Stefan Blankenberg
    INSERM U525, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Circulation 108:2453-9. 2003
    ..Interleukin (IL)-18 promotes atherosclerotic plaque growth and vulnerability. It is unknown, however, whether elevations of circulating IL-18 precede the onset of coronary events in apparently healthy individuals...
  13. ncbi Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability
    Z Mallat
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 104:1598-603. 2001
    ..Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown...
  14. pmc Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo
    S Finotto
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Gut 53:392-400. 2004
    b>Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells.
  15. pmc IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions
    Hiroshi Konishi
    Department of Dermatology, Mie University School of Medicine, Tsu 514 8507, Japan
    Proc Natl Acad Sci U S A 99:11340-5. 2002
    ..Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD...
  16. ncbi Defective NK cell activity and Th1 response in IL-18-deficient mice
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 8:383-90. 1998
    ..We therefore generated mice lacking both IL-18 and IL-12. In these mice, NK activity and Th1 response were further impaired. This demonstrates the important role of both IL-18 and IL-12 in NK activity, as well as in in vivo Th1 response...
  17. pmc Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells
    James A Harker
    Department of Respiratory Medicine, Centre for Respiratory Infection, National Heart and Lung Institute, Imperial College London, St Mary s Campus, London W2 1PG, United Kingdom
    J Virol 84:4073-82. 2010
    ..We therefore constructed a recombinant RSV expressing murine interleukin 18 (RSV/IL-18), a cytokine capable of inducing strong antiviral immune responses...
  18. ncbi Serum interleukin 18 and tumour necrosis factor-alpha levels are increased in Behcet's disease
    M O Oztas
    Department of Dermatology, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey
    Clin Exp Dermatol 30:61-3. 2005
    ..627, P < 0.0001). IL-18 and TNF-alpha levels may be related to disease pathogenesis. Increased levels of IL-18 also support Th1 predominance in Behcet's disease...
  19. ncbi Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  20. pmc Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    Sarah E Warren
    Department of Immunology, University of Washington, Seattle WA 98195, USA
    J Immunol 180:7558-64. 2008
    ..Thus, L. monocytogenes activates caspase 1 in macrophages via multiple pathways, all of which detect the presence of bacteria within the cytosol...
  21. ncbi Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    Thirumala Devi Kanneganti
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:36560-8. 2006
    ..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production...
  22. pmc MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    Rosalba Salcedo
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA
    J Exp Med 207:1625-36. 2010
    ..This study revealed a previously unknown level of complexity surrounding MyD88 activities downstream of different receptors that impact tissue homeostasis and carcinogenesis...
  23. ncbi Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease
    M Kawashima
    Okayama University Medical School, Japan
    Arthritis Rheum 44:550-60. 2001
    ..The disease activity appears to be determined on the basis of the relative levels of IL-18 and its specific inhibitors...
  24. ncbi Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention
    Heiko Muhl
    Pharmazentrum Frankfurt, University Hospital, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Eur J Pharmacol 500:63-71. 2004
    ..Here we introduce into the biology of interleukin-18 and review immunopharmacological strategies that aim at reducing interleukin-18 bioactivity in human disease...
  25. ncbi Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation
    V Giedraitis
    Division of Neurology, Huddinge University Hospital, Karolinska Institute, S 141 86, Huddinge, Sweden
    J Neuroimmunol 112:146-52. 2001
    ..In summary, our data indicate that common IL-18 promoter polymorphisms influence the expression of IL-18 and potentially also of IFN-gamma...
  26. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
    ..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
  27. ncbi IL-18 in autoimmunity: review
    Diana Boraschi
    Laboratory of Cytokines, Unit of Immunobiology, Institute of Biomedical Technologies, National Research Council, CNR, Area della Ricerca di S Cataldo, Via G Moruzzi 1, I 56124 Pisa, Italy
    Eur Cytokine Netw 17:224-52. 2006
    ..Unravelling the mechanisms of IL-18 production and activity in autoimmune diseases will allow the identification of targets for more effective therapeutic intervention...
  28. ncbi The P2X7 receptor: a key player in IL-1 processing and release
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    J Immunol 176:3877-83. 2006
    ....
  29. ncbi Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice
    Takahiro Ishikura
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 18:960-9. 2003
    ..However, the initial role of IL-18 during intestinal inflammation was unclear; therefore the susceptibility of IL-18 transgenic (Tg) mice to acute dextran sulfate sodium (DSS)-induced colitis was examined...
  30. ncbi Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population
    S O Olusi
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
    Horm Res 60:29-33. 2003
    ..To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults...
  31. ncbi IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells
    F D Shi
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 165:3099-104. 2000
    ..Thus, IL-18 can direct autoreactive T cells and promote autodestruction in the CNS at least in part via induction of IFN-gamma by NK cells...
  32. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  33. ncbi IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis
    P Hewins
    Renal Immunobiology, Medical School, University of Birmingham, Birmingham, UK
    Kidney Int 69:605-15. 2006
    ..We conclude that IL-18 is likely to be important for neutrophil recruitment and priming in ASV. Therapies targeting single priming agents may have limited efficacy in controlling disease...
  34. pmc Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate
    Michele Bombardieri
    Rheumatology Department, GKT School of Medicine, King s College London, UK
    Arthritis Res Ther 6:R447-56. 2004
    ....
  35. ncbi Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography
    Wang Ling
    Renal Division, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nephron Clin Pract 108:c176-81. 2008
    ....
  36. ncbi Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)
    Hirokazu Mitsuoka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Atherosclerosis 202:176-82. 2009
    ..A proinflammatory cytokine interleukin 18 (IL-18) and its receptor are prominently expressed in atherosclerotic plaques...
  37. ncbi A role for IL-18 in neutrophil activation
    B P Leung
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Immunol 167:2879-86. 2001
    ..Together, these data define a novel role for IL-18 in activating neutrophils and thereby promoting early innate immune responses...
  38. ncbi Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
    Katherine Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 289:1799-804. 2003
    ..Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue...
  39. pmc Differences in signaling pathways by IL-1beta and IL-18
    Jae Kwon Lee
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:8815-20. 2004
    ..We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever...
  40. ncbi Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
    T L Born
    Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 273:29445-50. 1998
    ..We propose that although IL-1R-rp1 binds the cytokine, IL-1R-rp1 and AcPL proteins are both required for IL-18 signaling, analogous to the requirement for both IL-1R and IL-1RAcP in IL-1-mediated responses...
  41. ncbi Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes
    Yoshimasa Aso
    Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Diabetes Care 26:2622-7. 2003
    ....
  42. ncbi Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    Thirumala Devi Kanneganti
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Nature 440:233-6. 2006
    ..These results reveal a critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes...
  43. ncbi Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death
    Sulagna Das
    National Brain Research Centre, Manesar, Haryana, India
    J Neuroimmunol 195:60-72. 2008
    ..In vitro, these two cytokines differentially activate microglia and astrocyte, and also alter the by stander neuronal survival following treatment with these two cytokines...
  44. ncbi Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease
    Der Yuan Chen
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    J Rheumatol 31:2189-98. 2004
    ..To investigate concentrations of proinflammatory cytokines in the sera and their mRNA expression in biopsy specimens of evanescent rash and synovitis from patients with active untreated adult onset Still's disease (AOSD)...
  45. pmc Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus
    J K Olson
    Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Medical School, Chicago, Ilinois 60611, USA
    J Virol 75:9780-9. 2001
    ..Thus, TMEV infection of microglia activates these cells to initiate an innate immune response which may lead to the activation of naive and memory virus- and myelin-specific adaptive immune responses within the CNS...
  46. ncbi Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23
    G Piskin
    Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands
    Exp Dermatol 13:764-72. 2004
    ..Therapies targeting these three cytokines should, therefore, be considered in the treatment of psoriasis...
  47. ncbi The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
    Thomas Skurk
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University Munich, D 85350 Weihenstephan, Germany
    Eur J Endocrinol 152:863-8. 2005
    ..The aim of our study was to investigate whether human adipocytes produce IL-18...
  48. ncbi Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes
    John N Fain
    Department of Molecular Sciences, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Metabolism 55:1113-21. 2006
    ..antagonist (IL-1Ra), cathepsin S, macrophage migration inhibitory factor (MIF), nerve growth factor (NGF), and interleukin 18 (IL-18) by adipocytes as compared with the non-fat cells present in subcutaneous and omental adipose tissue ..
  49. ncbi Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    Jeremy Dupaul-Chicoine
    Department of Biochemistry, McGill University, Quebec, Canada
    Immunity 32:367-78. 2010
    ..Taken together, our results indicate that the inflammatory caspases are critical in the induction of inflammation in the gut after injury, which is necessary for tissue repair and maintenance of immune tolerance...
  50. ncbi Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults
    M L Kohut
    Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Iowa State University, Ames, IA, USA
    Brain Behav Immun 20:201-9. 2006
    ..In summary, we have observed that an aerobic exercise intervention can significantly reduce serum inflammatory mediators, but beta-adrenergic receptors and psychosocial factors do not appear to be involved...
  51. ncbi In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells
    T Hoshino
    Laboratory of Experimental Immunology, DBS, NCI FCRDC, Frederick, USA
    Eur J Immunol 30:1998-2006. 2000
    ..1 mAb. These results suggest that IL-18 can induce Th2 cytokines and CD154 expression, and can contribute to CD4+ T cell-dependent, IL-4-independent IgE production...
  52. ncbi The age-related attenuation in long-term potentiation is associated with microglial activation
    Rebecca Griffin
    Trinity College Institute for Neuroscience and Physiology Department, Trinity College, Dublin, Ireland
    J Neurochem 99:1263-72. 2006
    ..We propose that signs of neuroinflammation are observed in middle age and that these changes, which are characterized by microglial activation, may be triggered by IL-18...
  53. ncbi Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 157:465-71. 2007
    ....
  54. ncbi Th1 cytokines in the pathogenesis of lupus nephritis: the role of IL-18
    Nicola Calvani
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari, Piazza Giulio Ceasare 11, 70124 Bari, Italy
    Autoimmun Rev 4:542-8. 2005
    ..In this context, IL-18 represents a novel marker of lupus nephritis and its measurement may be helpful in the assessment of patients...
  55. ncbi Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS
    Shuei Sugama
    Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR307, La Jolla, CA 92037, USA
    Brain Res 958:1-9. 2002
    ..They also suggest that ependymal cells may be the source of IL-18 previously reported in the cerebrospinal fluid (CSF). The role of IL-18 in the ependyma and the CSF remains to be elucidated...
  56. pmc Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease
    D Y Chen
    Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, No 160, Section 3 Taichung Kang Road, Taichung City, 40705 Taiwan
    Ann Rheum Dis 63:1300-6. 2004
    ..To determine the type 1 T helper (Th1)/type 2 T helper (Th2) balance in the peripheral blood (PB) and pathological tissues of patients with active untreated adult onset Still's disease (AOSD)...
  57. ncbi Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation
    C R Parikh
    Nephrology, Yale University, New Haven, Connecticut, USA
    Am J Transplant 6:1639-45. 2006
    ..01). Our results indicate that urine NGAL and IL-18 represent early, predictive biomarkers of DGF...
  58. ncbi Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity
    Beixing Liu
    Department of Microbiology, Fukui Medical University School of Medicine, Shimoaisuki 23 3, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    J Gen Virol 85:423-8. 2004
    ..These results indicate that IL-18 is involved in controlling influenza virus replication in the lung, especially at an early stage of infection, through activation of the innate immune mechanisms such as IFN and NK cells...
  59. pmc ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection
    Ingrid C Koo
    Program in Microbial Pathogenesis and Host Defense, University of California, San Fancisco, CA, USA
    Cell Microbiol 10:1866-78. 2008
    ..Collectively, these results reveal a role for ESX-1 in triggering secretion of lysosomes, as well as release of IL-1beta and IL-18 during mycobacteria infection...
  60. ncbi Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor culture
    Yu Peng Liu
    Department of Life Sciences, National Cheng Kung University, 1 Ta Hsueh Rd, Tainan 70101, Taiwan
    Brain Res 1054:152-8. 2005
    ....
  61. ncbi Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability
    Z Mallat
    Institut National de la Sante et de la Recherche Medicale, Unité 541, et Institut Fédératif de Recherche Paris VII, Hopital Lariboisiere, France
    Circ Res 89:E41-5. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  62. ncbi The dual effects of interleukin-18 in tumor progression
    Sunyoung Park
    Department of Life Science, Sookmyung Women s University, Chungpa dong 2 Ka, Yongsan Ku, Seoul 140 742, Korea
    Cell Mol Immunol 4:329-35. 2007
    ..These dual effects and the mechanism of IL-18 need to be investigated further as it relates to cancer...
  63. ncbi The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression
    Christian Bauer
    Division of Clinical Pharmacology, Medizinische Klinik Innenstadt of the University of Munich, Munich, Germany
    Dig Dis Sci 52:1642-52. 2007
    ....
  64. ncbi Inflammasomes: guardians of cytosolic sanctity
    Mohamed Lamkanfi
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Immunol Rev 227:95-105. 2009
    ..Further understanding of inflammasomes and their role in innate immunity should provide new insights into the mechanisms of host defense and the pathogenesis of autoimmune diseases...
  65. ncbi Decreased interleukin-18 expression in BAL cells and peripheral blood mononuclear cells in adult cystic fibrosis patients
    Hans Peter Hauber
    Department of Internal Medicine, University Hospital Eppendorf, Hamburg, Germany
    J Cyst Fibros 3:129-31. 2004
    ..Stimulation with rhIL-10 reduced IL-18 expression in PBMC from CF patients. Decreased IL-18 expression in CF patients may contribute to decreased IFN-gamma production. IL-10 may contribute to inhibit IL-18 expression in PBMC in CF...
  66. ncbi Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients
    H D Shin
    Department of Genetic Epidemiology, SNP Genetics, Inc, MaeHun B D, Seoul, South Korea
    Allergy 60:900-6. 2005
    ..The possible involvement of IL18 polymorphisms in asthma was examined in a Korean asthma cohort...
  67. ncbi TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells
    Konstantinos A Papadakis
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, CA 90048, USA
    J Immunol 172:7002-7. 2004
    ..Our data suggest that TL1A/DR3 pathway plays an important role in the augmentation of cytokine-induced IFN-gamma production in T cells and that DR3 expression is differentially regulated by IL-12/IL-18 in T cells and NK cells...
  68. ncbi Association of interleukin 18 gene polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery
    S Chen
    Department of Thoracic Surgery, Jiangsu Province Tumor Hospital, Nanjing Medical University, Nanjing, PR China
    Tissue Antigens 76:245-9. 2010
    ..b>Interleukin 18 (IL-18) is a potent activator and inducer of accumulating neutrophils in lung, and higher IL-18 level has been ..
  69. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
    ..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response...
  70. pmc A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production
    M Neighbors
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Incorporated, Palo Alto, CA 94304, USA
    J Exp Med 194:343-54. 2001
    ..Therefore, IL-18 operates via its effects on both the innate immune response, including macrophages, as well as on Th1 cells, to protect against Listeria...
  71. pmc Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease
    V M Salvati
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Gut 50:186-90. 2002
    ..IL-18 is a recently described cytokine capable of promoting T cell interferon (IFN)-gamma production and facilitating Th1 cell polarisation...
  72. ncbi Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    Eur J Immunol 30:3057-60. 2000
    ....
  73. ncbi VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer
    Ewa Jablonska
    Department of Immunology, Medical University of Bialystok, Waszyngtona 15A, 15 274 Bialystok, Poland
    Cytokine 30:93-9. 2005
    ..Furthermore, our results suggest that the concentrations of VEGF and IL-18 in the serum are sensitive tumour markers in this patient group before and after treatment...
  74. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells...
  75. ncbi Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia
    Masaki Okamoto
    Department of Internal Medicine, Kurume University School of Medicine, Japan
    Blood 99:1289-98. 2002
    b>Interleukin 18 (IL-18) was discovered as an interferon-gamma (IFN-gamma)-inducing factor and plays important roles in natural killer (NK) cell activation...
  76. pmc Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
    ..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction...
  77. pmc Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice
    A Mencacci
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    Infect Immun 68:5126-31. 2000
    ....
  78. ncbi Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
    T Ghayur
    BASF Bioresearch Corporation, Worcester, Massachusetts 01605 4314, USA
    Nature 386:619-23. 1997
    ..Specific caspase-1 inhibitors would provide a new class of anti-inflammatory drugs with multipotent action...
  79. ncbi Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al
    Nobuaki Maeno
    Arthritis Rheum 46:2539-41; author reply 2541-2. 2002
  80. pmc Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia
    Marius Trøseid
    Center for Clinical Heart Research, Department of Cardiology, University of Oslo, Oslo, Norway
    Diabetes Care 32:486-92. 2009
    ..The aim of this study was to investigate the role of inflammatory markers as potential predictors of cardiovascular events in subjects with and without the metabolic syndrome...
  81. ncbi Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice
    Denise P Abulafia
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Cereb Blood Flow Metab 29:534-44. 2009
    ..These findings show that the inflammasome complex forms after focal brain ischemia and may be a novel therapeutic target for reducing the detrimental consequences of postischemic inflammation...
  82. ncbi Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance
    Joseph Hung
    Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western Australia, and School of Medicine and Pharmacology, University of Western Australia, Nedlands, Perth
    Arterioscler Thromb Vasc Biol 25:1268-73. 2005
    ..We sought to determine whether an elevated IL-18 concentration was a risk predictor for metabolic syndrome in a community population independent of obesity and hyperinsulinemia...
  83. ncbi Disease association of two distinct interleukin-18 promoter polymorphisms in Caucasian rheumatoid arthritis patients
    J A Gracie
    Centre for Rheumatic Diseases, University of Glasgow, Glasgow, Scotland, UK
    Genes Immun 6:211-6. 2005
    ..2 vs 1.2%) and in Scottish RA patients (4.1 vs 0.9%) than in the respective HD cohorts. These observations suggest that SNP of both positions contribute to the genetic background of RA pathogenesis...
  84. ncbi A molecular platform in neurons regulates inflammation after spinal cord injury
    Juan Pablo de Rivero Vaccari
    Department of Physiology and Biophysics and Neurological Surgery and Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 28:3404-14. 2008
    ..Thus, rat spinal cord neurons contain a caspase-1, pro-ILbeta, and pro-IL-18 activating complex different from the human NALP1 inflammasome that constitutes an important arm of the innate CNS inflammatory response after SCI...
  85. ncbi IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response
    T Hoshino
    Laboratory of Experimental Immunology, Division of Basic Sciences, National Cancer Institute, Frederick Cancer and Research Development Center, MD 21702, USA
    J Immunol 162:5070-7. 1999
    ..Thus, depending upon the cell type, IL-18 may act as a strong coinducer of Th1 or Th2 cytokines. Our findings suggest that IL-12 and IL-18 have different roles in the regulation of gene expression in NK and T cells...
  86. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  87. pmc Regulation of human NK-cell cytokine and chemokine production by target cell recognition
    Cyril Fauriat
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Blood 115:2167-76. 2010
    ..Conceptually, the results point to CD56(dim) NK cells as an important source of cytokines and chemokines upon recognition of aberrant cells, producing graded responses depending on the multiplicity of activating receptors engaged...
  88. ncbi Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18
    Rance E Berg
    Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NA2 200, Dallas, TX 75390 9093, USA
    Eur J Immunol 32:2807-16. 2002
    ..Together, these data suggest an important role for IFN-gamma-secreting CD8+ T cells in the innate response to bacterial pathogens...
  89. ncbi Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function
    T Hoshino
    Department of Internal Medicine 1, Kurume University, Kurume, Japan
    J Immunol 166:7014-8. 2001
    ..Splenic T cells in IL-18 Tg mice produced higher levels of IFN-gamma, IL-4, IL-5, and IL-13 than control wild-type mice. Thus, aberrant expression of IL-18 in vivo results in the increased production of both Th1 and Th2 cytokines...
  90. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
    ..The combination of these two biomarkers may allow for the reliable early diagnosis and prognosis of AKI at all times after CPB, much before the rise in serum creatinine...
  91. ncbi NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1
    Claudia Semino
    Laboratory of Cell Biology, Department of Translational Oncology, National Institute for Cancer Research, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    Blood 106:609-16. 2005
    ..We show here that NK cells trigger immature DCs to polarize and secrete interleukin 18 (IL-18), a cytokine lacking a secretory leader sequence...
  92. ncbi Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 26:3129-35. 2003
    ..We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI...
  93. ncbi Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis
    Saurabh Sahar
    Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, Calif 91010, USA
    Circ Res 96:1064-71. 2005
    ..These results illustrate a novel mechanism wherein Ang II- mediated increases in inflammatory genes and proatherogenic effects in the vasculature are enhanced by a vicious loop and cross-talk with the IL-18 signaling pathway...
  94. pmc Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse
    Takaaki Sugimoto
    Department of Surgery, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, 663 8501, Japan
    J Exp Med 199:535-45. 2004
    ..Thus, Ag and IL-18 stimulate memory Th1 cells to induce severe airway inflammation and AHR in the naive host...
  95. ncbi Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection
    G C Pien
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 165:4787-91. 2000
    ..Taken together, our results delineate contrasting compartmental requirements for IL-18 and suggest that preservation of local, hepatic IFN-gamma production is critical for host defense during murine cytomegalovirus challenge...
  96. ncbi Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis
    M Yamamura
    Department of Medicine III, Okayama University Medical School, Japan
    Arthritis Rheum 44:275-85. 2001
    ..Detection of significant IL-18 bioactivity in the joints, despite the presence of IL-18 binding inhibitors, supports an integral role of this cytokine in perpetuating the IFNgamma-dominant T cell cytokine response in RA...
  97. ncbi The IL-1 family and inflammatory diseases
    C A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Clin Exp Rheumatol 20:S1-13. 2002
    ..This property, of IL-1 is not observed in the responses to TNFalpha. Furthermore, in animal models of destructive rheumatoid arthritis, IL-1 is necessary but TNFalpha is not...
  98. ncbi The role of IL-18 in innate immunity
    S Akira
    Department of Host Defense, CREST of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, Suita, 565 0871, Japan
    Curr Opin Immunol 12:59-63. 2000
    ..The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response...
  99. ncbi Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation
    Bysani Chandrasekar
    Department of Veterans Affairs South Texas Veterans Health Care System, San Antonio, Texas 78229 4404, USA
    J Biol Chem 283:4200-9. 2008
    ..Thus, targeting IL-18 expression may enhance adiponectin expression and mitigate disease progression...
  100. ncbi IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation
    Anthony R French
    Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, Box 8208, 660 South Euclid Ave, St Louis, MO 63110, USA
    Cytokine 35:229-34. 2006
    ..This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNgamma production...
  101. pmc Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection
    Barbel Raupach
    Department of Cellular Microbiology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
    Infect Immun 74:4922-6. 2006
    ..Thus, we show that Casp-1 is essential for host innate immune defense against S. enterica serovar Typhimurium and that Casp-1 substrates are required at distinct times and anatomical sites...

Research Grants62

  1. Substance P & the Regulation of Intestinal Inflammation
    Joel Weinstock; Fiscal Year: 2009
    ..Strategies aimed at modulating NK-1 R function in the gut could prove therapeutically beneficial for IBD. ..
  2. Brain interleukin-18 control of food intake and energy expenditure
    Eric P Zorrilla; Fiscal Year: 2013
    ..Such information will be key for beginning to understand the pathophysiologic and potential therapeutic relevance of central IL-18 signaling for disorders of energy homeostasis, such as obesity or cachexia. ..
  3. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..abstract_text> ..
  4. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Development of highly specific imaging agents for noninvasive detection of inflammation induced by heart attacks. ..
  5. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ....
  6. Interleukin-18 and post infarct myocardial remodeling
    Bysani Chandrasekar; Fiscal Year: 2013
    ..The primary goal of this proposal is to better understand the role of inflammatory cytokines, interleukin-18 in particular, in post-infarct myocardial injury, remodeling and failure. ..
  7. Caspase-1 and Inflammasome Activation in Traumahemorrhagic Shock
    Melanie J Scott; Fiscal Year: 2013
    ..Understanding these novel pathways of inflammatory activation and function in individual cell types and organs may help us find new ways to treat and prevent MOF in trauma patients in the future. ..
  8. Urinary Biomarkers of Chronic Kidney Disease Pathology and Progression
    Sushrut S Waikar; Fiscal Year: 2013
    ..The identification of clinically useful CKD biomarkers will improve the care of individuals with and at risk for CKD. ..
  9. IL-1 beta Signaling in Diabetic Retinopathy
    Susanne Mohr; Fiscal Year: 2010
    ..These studies will clarify if the caspase-1/interleukin-1beta signaling pathway is essential for the development of diabetes-induced retinal pathology. ..
  10. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2013
    ..The primary goal of this proposal is to better understand the role of inflammatory cytokines, interleukin-18 in particular, in myocardial hypertrophy and its transition to failure. ..
  11. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..This study aims to identify, at the earliest possible time point, which patients are most likely to have complications related to kidney injury in order to provide safer care and reduce the potential for greater injury in the hospital. ..
  12. Hepatitis C Pathogenesis and the Human Genome
    David L Thomas; Fiscal Year: 2013
    ..preliminary findings focusing on key elements of the immune response including human leukocyte antigen - C and interleukin 18. Innovative approaches are employed including searching for the explanation for why the same HLA allele would ..
  13. Structure-function studies on IL-18, IL-18 binding proteins and receptors
    Junpeng Deng; Fiscal Year: 2012
    ..It may benefit efforts in developing treatments against some autoimmune and inflammatory diseases, in developing immunotherapies against other infectious diseases and cancer and in combating bioterrorism. ..
  14. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  15. "Validation of Novel CKD Biomarkers in CRIC"
    Kathleen D Liu; Fiscal Year: 2013
    ....
  16. Recognition of HIV by the Inflammasome Signaling Complex
    MICHAEL ANAND CHATTERGOON; Fiscal Year: 2013
    ..A clear understanding of this process will have implications for managing and treating both the primary viral infection and the co-morbid medical conditions, which are often exacerbated by prolonged immune activation. ..
  17. Immune modulation mechanism mediated by poxvirus IL-18 binding protein
    Yan Xiang; Fiscal Year: 2011
    ..A comprehensive understanding of IL-18BP functioning mechanism and in vivo effects will lead to new therapies for poxvirus diseases and better poxvirus-based vaccines. ..
  18. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2013
    ..The long-range goal of this work is to develop an approach to systematically identify genes that contribute to normal variation in fatness among mice. ..
  19. Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction
    Chirag R Parikh; Fiscal Year: 2010
    ..Urinary biomarkers, such as IL-18 and NGAL, which are valuable for identifying acute tubular necrosis in other clinical settings, will be tested in patients with renal failure and cirrhosis in this prospective cohort study. ..
  20. Comparative Evaluation of Urinary Biological Markers for the Prognostic Stratific
    Bertrand Jaber; Fiscal Year: 2009
    ....
  21. ADRENAL REGENERATION-- IMMUNO-ENDOCRINE INTERACTIONS
    WILLIAM ENGELAND; Fiscal Year: 2003
    ....
  22. Interleukin-18 and Intestinal Barrier Function Following Alcohol and Burn Injury
    Mashkoor Choudhry; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Amyloid Precursor Proteins in Sarcoidosis
    DAVID MOLLER; Fiscal Year: 2005
    ..abstract_text> ..
  24. Poxvirus immune modulators and the host Immune system
    Yan Xiang; Fiscal Year: 2004
    ..abstract_text> ..
  25. The IL-18/Caspase-1 cascade in atherosclerosis
    Guo Ping Shi; Fiscal Year: 2006
    ..In previous work, the applicants and others associated enhanced expression of interleukin 18 (IL-18), a member of the IL-1 cytokine family, with pro-atherogenic functions...
  26. CENTRAL NERVOUS SYSTEM DYSFUNCTION IN SHOCK AND TRAUMA
    Tracy McIntosh; Fiscal Year: 2003
    ..amp;#9; ..
  27. Pathogenesis of Endotoxemia-Induced Acute Renal Failure
    Robert Schrier; Fiscal Year: 2005
    ..The ultimate goal therefore is to understand and prevent the ARF, morbidity and mortality associated with sepsis. ..
  28. A model of obesity-associated severe acute pancreatitis
    Giamila Fantuzzi; Fiscal Year: 2007
    ..Preliminary data indicate that daily administration of a combination of interleukin-12 and interleukin 18 - two cytokines that are increased in the circulation of AP patients - for 3 to 5 days induces mild pancreatic ..
  29. Interleukin-18 in inflammation and angiogenesis
    CHRISTY PARK; Fiscal Year: 2005
    ....
  30. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2006
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  31. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2004
    ..clinical trials since we will attempt combination immunotherapy and inhibit newly described cytokines such as interleukin 18. The second specific aim will tailor the anti-inflammatory therapy based on the individual response...
  32. CYTOKINE SECRETION PROFILE OF AUTOREACTIVE T CELLS
    Christine Rohowsky Kochan; Fiscal Year: 2004
    ..Elucidating the mechanisms that control IFN-y production is essential for unraveling the pathogenesis of MS and may be of therapeutic benefit. ..
  33. Role of IL18 in Spread of Prostate Cancer to Bone
    Pamela Russell; Fiscal Year: 2004
    ..If IL18 inhibits PCa growth in bone, its delivery by adenovirus vectors into the prostate of patients prior to radical prostatectomy may prevent the development of bone metastasis. ..
  34. Interleukin 18 and Atherosclerosis during Stress
    Bruno Conti; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Interleukin 18 (IL-18) is a pro-inflammatory cytokine with pro-atherogenic properties whose level can be elevated by psychological stress...
  35. EVALUATION OF SIV EXPRESSING IGIF
    Luis Giavedoni; Fiscal Year: 2001
    ..These experiments may provide additional evidence to support the hypothesis that the immune system can be regulated to fight insults by providing the appropriate cytokines at the right times. ..
  36. CYTOKINES AS CANCER IMMUNOTHERAPEUTICS
    Hua Yu; Fiscal Year: 2001
    ..1 and IL-12, in adjunctive antitumor therapies. New knowledge gained from these studies may eventually increase the spectrum of human cancers curable by immunotherapeutics. ..
  37. Innate immune gene SNPS in African-Americans with RA
    Patricia Fraser; Fiscal Year: 2005
    ..for microbial pathogens, such as Toll-like receptor 4 (TLR-4), as well as those affected by the TH1 enhancer interleukin 18 (IL-18), may also modulate RA risk...
  38. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  39. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  40. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  42. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  43. The Role of IL-18 in Ischemic Acute Renal Failure
    Sarah Faubel; Fiscal Year: 2007
    ..The results of these experiments will contribute to the understanding of the pathogenesis of ischemic ARF, as well as ischemia in other organs. ..
  44. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  45. Mechanisms of IL-18 Mediated Regulation of GVHD and GVL
    Pavan Reddy; Fiscal Year: 2006
    ..The applicant's sponsor guarantees that 80% of Dr. Reddy's effort will be devoted to his research during this award. ..
  46. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  47. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  48. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  49. Exercise & influenza immunity:Psychoneuroendocrine Model
    Marian Kohut; Fiscal Year: 2004
    ..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
  50. Mentored Patient-Oriented Research Career Development Aw
    ASHER SCHACHTER; Fiscal Year: 2004
    ..These studies may provide insight and guidance for the development of markers of steroid resistance as well as novel therapies for SRNS. ..
  51. Role of Antioxidants in Ovarian Thecal Hyperplasiar
    Antoni Duleba; Fiscal Year: 2005
    ..abstract_text> ..
  52. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  53. Helminth-Induced Immune Tolerance in Asthma
    Joel Kline; Fiscal Year: 2005
    ..Although completion of the second Aim is almost certainly beyond the scope of this two-year developmental research grant, these studies will be continued and extended through an R01 grant application. ..
  54. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2006
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  55. Novel Functions of PYRIN proteins
    Christian Stehlik; Fiscal Year: 2007
    ..The here proposed work extends our long-term goal to define the mechanisms that link pathogen recognition to the innate immune response. [unreadable] [unreadable] [unreadable]..
  56. Polymer Carrier for Ischemia-Inducible Gene Therapy
    David Bull; Fiscal Year: 2007
    ..abstract_text> ..
  57. Identification of Early Markers for Ovarian Cancer
    Anna Lokshin; Fiscal Year: 2006
    ..By the end of the proposed project, we expect to construct a test based on a panel of ovarian cancer-specific antigens that has the most promising characteristics to identify women with ovarian cancer. ..
  58. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  59. Mucosal Therapy for Autoimmunity
    David Pascual; Fiscal Year: 2008
    ..Studies in Specific Aim 3 will determine the responsible dendritic cell subset that supports regulatory T cell development. ..
  60. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
    ..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..
  61. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..