interleukin 15

Summary

Summary: Cytokine that stimulates the proliferation of T-lymphocytes and shares biological activities with IL-2. IL-15 also can induce B-lymphocyte proliferation and differentiation.

Top Publications

  1. ncbi IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101, USA
    J Leukoc Biol 57:763-6. 1995
  2. ncbi Cytokine control of memory T-cell development and survival
    Kimberly S Schluns
    Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 1319, USA
    Nat Rev Immunol 3:269-79. 2003
  3. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
  4. ncbi The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
    Thomas A Waldmann
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 6:595-601. 2006
  5. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
  6. ncbi IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
    Sigrid Dubois
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:537-47. 2002
  7. ncbi IL-15/IL-15 receptor biology: a guided tour through an expanding universe
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Cytokine Growth Factor Rev 17:259-80. 2006
  8. pmc Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
    Thomas A Stoklasek
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 177:6072-80. 2006
  9. ncbi Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs
    Todd A Fehniger
    Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 26:798-811. 2007
  10. pmc Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides
    D Bernardo
    Gut 56:889-90. 2007

Detail Information

Publications303 found, 100 shown here

  1. ncbi IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101, USA
    J Leukoc Biol 57:763-6. 1995
    b>Interleukin 15 is a newly discovered cytokine that shares biological activities with IL-2 and, like IL-2, is a member of the four-helix bundle cytokine family...
  2. ncbi Cytokine control of memory T-cell development and survival
    Kimberly S Schluns
    Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 1319, USA
    Nat Rev Immunol 3:269-79. 2003
    ..In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained...
  3. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting...
  4. ncbi The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
    Thomas A Waldmann
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 6:595-601. 2006
    ..As discussed in this Review, the biology of these cytokines will affect the development of novel therapies for malignancy and autoimmune diseases, as well as the design of vaccines against infectious diseases...
  5. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
    ....
  6. ncbi IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
    Sigrid Dubois
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:537-47. 2002
    ..Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8(+) T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction...
  7. ncbi IL-15/IL-15 receptor biology: a guided tour through an expanding universe
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Cytokine Growth Factor Rev 17:259-80. 2006
    ..Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance...
  8. pmc Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
    Thomas A Stoklasek
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 177:6072-80. 2006
    ..These findings hold significant importance for the use of IL-15 as a potential adjuvant/therapeutic and inducer of homeostatic proliferation, without the necessity for prior immunodepletion...
  9. ncbi Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs
    Todd A Fehniger
    Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 26:798-811. 2007
    ..These data suggest that resting murine NK cells are minimally cytotoxic because of a block in perforin and granzyme B mRNA translation that is released by NK cell activation...
  10. pmc Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides
    D Bernardo
    Gut 56:889-90. 2007
  11. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  12. ncbi Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease
    Jean Jacques Mention
    INSERM EMI 0212, Faculte Necker, Paris
    Gastroenterology 125:730-45. 2003
    ....
  13. ncbi Interleukin-21 inhibits dendritic cell activation and maturation
    Katja Brandt
    Research Center Borstel, Dept of Immunology and Cell Biology, Parkallee 22, 23845 Borstel, Germany
    Blood 102:4090-8. 2003
    ....
  14. ncbi Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression
    S Dubois
    Groupe de Recherche Cytokines et Récepteurs, Unité INSERM 463, Institut de Biologie, 9 quai Moncousu, 44035 Nantes Cedex 01, France
    J Biol Chem 274:26978-84. 1999
    ..Together, our data indicate that exon 2 splicing of human IL-15Ralpha is a natural process that might play regulatory roles at different levels...
  15. pmc Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101, USA
    EMBO J 14:3654-63. 1995
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2...
  16. ncbi Prognostic value of interleukin 2 and interleukin 15 in peritumoral hepatic tissues for patients with hepatitis B-related hepatocellular carcinoma after curative resection
    Haijun Zhou
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China
    Gut 59:1699-708. 2010
    ..This study evaluated the prognostic values of intratumoral and peritumoral Th1/Th2 cytokine protein levels in patients with HCC after curative resection...
  17. ncbi The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
    M Orchardson
    Department of Immunology and Bacteriology and Center of Rheumatic Disease, University of Glasgow, Glasgow, United Kingdom
    J Immunol 167:277-82. 2001
    ..Thus, the Sushi domain is critical for the functional activity of sIL-15Ralpha...
  18. pmc Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells
    Adam D Judge
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 196:935-46. 2002
    ..Thus, subsets of memory-phenotype T cells differ radically in their sensitivity to IL-15...
  19. ncbi Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophages
    Janice J Endsley
    Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Leukoc Biol 79:71-9. 2006
    ..These NK cell receptors bearing T lymphocytes may represent memory subsets characterized in humans. The results of these studies demonstrate that bovine NK cells may play an important role in the innate immune responses of cattle...
  20. pmc Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells
    Todd C Becker
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 195:1541-8. 2002
    ..Taken together, these results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time...
  21. pmc Safety and immunologic effects of IL-15 administration in nonhuman primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 114:2417-26. 2009
    ..These findings demonstrate that IL-15 has profound immunomodulatory properties distinct from those described for IL-2, and suggest that intermittent administration of IL-15 should be considered in clinical studies...
  22. ncbi IL-15 is an essential mediator of peripheral NK-cell homeostasis
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    Blood 101:4887-93. 2003
    ..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells...
  23. ncbi Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    Bertrand Meresse
    Department of Pathology, University of Chicago, IL 60637, USA
    Immunity 21:357-66. 2004
    ....
  24. pmc Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides
    Y Tagaya
    Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:14444-9. 1997
    Two isoforms of human interleukin 15 (IL-15) exist...
  25. ncbi Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
    Hisataka Kobayashi
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:721-7. 2005
    b>Interleukin 15 (IL-15) is a critical factor for the proliferation and activation of natural killer (NK) and CD8 T cells...
  26. ncbi IL-15 promotes the survival of naive and memory phenotype CD8+ T cells
    Marion Berard
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 170:5018-26. 2003
    ..These results show that IL-15 has multiple effects on CD8 T cells and possesses the potential to regulate the life span of naive as well as memory CD8(+) T cells...
  27. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    b>Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we identify Bim, Noxa and Mcl-1 as key regulators of IL-15-dependent survival of NK cells...
  28. ncbi Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
    Mami Chirifu
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Nat Immunol 8:1001-7. 2007
    b>Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share beta- and gamma-signaling subunits...
  29. pmc Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101
    EMBO J 13:2822-30. 1994
    ..The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component...
  30. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
    ..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response...
  31. ncbi NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment
    A I Roberts
    Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    J Immunol 167:5527-30. 2001
    ..Uncontrolled secretion of IL-15 could lead to excessive induction of NKG2D and thus contribute to the development of autoimmune disease by facilitating the activation of autoreactive T cells...
  32. ncbi Differential regulation of T-cell growth by IL-2 and IL-15
    Georgina H Cornish
    Cancer Research UK, London, England
    Blood 108:600-8. 2006
    ..Hence, the present results show that cytokines that are equivalent mitogens can have different potency in terms of regulating protein synthesis and cell growth...
  33. ncbi A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
    Sophie Hue
    Equipe Avenir Inserm, Hopital Necker Enfants Malades, 75015 Paris, France
    Immunity 21:367-77. 2004
    ..This supports a key role for MIC/NKG2D in the activation of intraepithelial immunity in response to danger...
  34. ncbi Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 163:4064-72. 1999
    ..These data suggest the existence of two autocrine loops involving IL-15/IL-15R and IL-2/IL-2R, both contributing to the spontaneous proliferation of HAM/TSP PBMC...
  35. ncbi IL-15 expression at human endometrium and decidua
    K Kitaya
    Department of Obstetrics and Gynecology and Dynamic Pathology Research Institute, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Biol Reprod 63:683-7. 2000
    ..These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone...
  36. pmc IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
    Yvonne M Mueller
    Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 180:350-60. 2008
    ..Finally, IL-15-treated acutely SIV-infected primates may serve as a useful model to investigate the poorly understood mechanisms that control viral set point and disease progression in HIV infection...
  37. ncbi IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro
    Wanda Niedbala
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, Scotland, GB
    Eur J Immunol 32:341-7. 2002
    b>Interleukin 15 (IL-15) is a pleiotropic cytokine produced principally by monocytes and affects both innate and acquired immunity...
  38. ncbi The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines
    C C Ku
    Howard Hughes Medical Institute, Department of Immunology, National Jewish Medical and Research Center, University of Colorado Medical School, Denver, CO 80207, USA
    J Immunol 166:2186-93. 2001
    ..Thus they might affect the immune response of their hosts by competing for factors that stimulate and inhibit normal CD8(+) memory T cells...
  39. ncbi IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
    Adrianna Moroz
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 173:900-9. 2004
    ..These findings indicate that the mechanisms used by IL-21 to promote CD8(+) T cell responses offer unique opportunities for its use in malignant diseases and infections...
  40. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005
    ..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice...
  41. ncbi IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation
    Anthony R French
    Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, Box 8208, 660 South Euclid Ave, St Louis, MO 63110, USA
    Cytokine 35:229-34. 2006
    ..This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNgamma production...
  42. ncbi Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 270:29862-9. 1995
    ..However, the distribution of expression of the IL-15R alpha is much wider than that of the IL-2R alpha, suggesting a broader range of cellular targets for IL-15...
  43. pmc How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    Erwin H Duitman
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 28:4851-61. 2008
    ....
  44. pmc Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model
    Louise S Villadsen
    Department of Dermatology, Gentofte University Hospital, Copenhagen, Denmark
    J Clin Invest 112:1571-80. 2003
    ..These results obtained with this IL-15-specific mAb support an important role for IL-15 in the pathogenesis of psoriasis...
  45. pmc Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells
    T A Fehniger
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Exp Med 193:219-31. 2001
    ..Later, these mice develop fatal lymphocytic leukemia with a T-NK phenotype. These data provide novel evidence that leukemia, like certain other cancers, can arise as the result of chronic stimulation by a proinflammatory cytokine...
  46. ncbi CD69 expression on lymphocytes and interleukin-15 levels in synovial fluids from different inflammatory arthropathies
    Ana M Ortiz
    Rheumatology Department, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Rheumatol Int 21:182-8. 2002
    ..The aim was to study a possible relationship between CD69 expression on lymphocytes and interleukin-15 (IL-15) levels in synovial fluid (SF) from patients with different inflammatory arthropathies...
  47. ncbi IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques
    F Villinger
    Department of Pathology and Laboratory Medicine, Emory University, Woodruff Memorial Building 2339, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Vaccine 22:3510-21. 2004
    ..Following booster immunization, however, only IL-15 appeared able to enhance CD8 T cell responses while IL-2 or IL2/IL-15 administration were less effective...
  48. ncbi Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence
    Simona Cavalieri
    Institute for Cancer Research and Treatment, University of Torino Medical School, Cadiolo Torino, Italy
    Blood 102:497-505. 2003
    ..Thus, LV transduction of IL-2 or IL-7 prestimulated cells overcomes the limitations of retroviral vectors and may significantly improve the efficacy of T-cell-based gene therapy...
  49. ncbi Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    J Infect Dis 187:1735-47. 2003
    ..Understanding cytokine effects on CCR5(+) T cells will be important in understanding chronic HIV-1 replication and pathogenesis...
  50. ncbi Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses
    Alicia R Mathers
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 182:921-33. 2009
    ..Overall, our data demonstrate that human epidermal smiLCs induce Th17 responses by mechanisms different from those previously described and highlight the need to target clinical treatments based on these variations...
  51. ncbi Intestinal epithelial cells both express and respond to interleukin 15
    H C Reinecker
    Department of Medicine, Massachusetts General Hospital, Boston, USA
    Gastroenterology 111:1706-13. 1996
    ..The aim of this study was to characterize the expression of IL-15 by intestinal epithelial cells and determine the functional roles of IL-15 within the mucosal immune system...
  52. pmc Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease
    F Abebe
    University of Oslo, Institute of General Practice and Community Medicine, Section for International Health, Oslo, Norway
    Clin Exp Immunol 143:180-92. 2006
    ..Our results, together with the above observations, suggest that IL-15 may play an important role in mediating active disease during Mtb infection...
  53. ncbi Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells
    H Yoshida
    Department of Molecular Genetics, Graduate School of Medicine, and Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo, Kyoto, Japan
    J Immunol 167:2511-21. 2001
    ....
  54. pmc Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression
    Kimberly S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 101:5616-21. 2004
    ..These results demonstrated dichotomous mechanisms by which IL-15 regulated lymphoid development, interacting with distinct cell types depending on the developmental pathway...
  55. pmc Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    Mathias Lucas
    Skirball Institute of Biomolecular Medicine, Program in Molecular Pathogenesis, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 26:503-17. 2007
    ..Our data define a unique in vivo role of DCs for the priming of NK cells, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system...
  56. ncbi A regulatory role of interleukin 15 in wound healing and mucosal infection in mice
    Yoshiko Kagimoto
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Leukoc Biol 83:165-72. 2008
    ..Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-beta1, promoting wound healing but impeding protection against genital HSV-2 infection...
  57. ncbi Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    K H Grabstein
    Immunex Research and Development Corporation, Seattle, WA 98101
    Science 264:965-8. 1994
    ..Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor...
  58. ncbi The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15
    G Kurys
    Metabolism Branch, NCI, National Institutes of Health and the Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1374, USA
    J Biol Chem 275:30653-9. 2000
    ..In terms of a more positive role, we propose that intracellular infection may relieve the burdens on translation and intracellular trafficking to yield effective IL-15 expression...
  59. ncbi Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    Seiichi Kuwajima
    Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
    Nat Immunol 7:740-6. 2006
    The function of interleukin 15 (IL-15) in unmethylated CpG oligodeoxynucleotide (CpG)-induced immune responses remains unknown...
  60. pmc Expression of interleukin-15 in mouse and human atherosclerotic lesions
    D M Wuttge
    Department of Medicine, Karolinska Hospital, Karolinska Institute, S 171 76 Stockholm, Sweden
    Am J Pathol 159:417-23. 2001
    ..In conclusion, IL-15 is up-regulated in both human and animal atherosclerotic lesions and may contribute to the recruitment of T cells and their activation during atherogenesis...
  61. pmc Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines
    Wai Kan Chiu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Immunol 177:7802-10. 2006
    ....
  62. pmc IL-15-induced conversion of monocytes to mature dendritic cells
    K U Saikh
    Laboratory of Molecular Immunology, Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Clin Exp Immunol 126:447-55. 2001
    ..Thus, the release of IL-15 by inflammatory stimuli may induce the conversion of monocytes to immuno-stimulatory dendritic cells to support primary immune responses against pathogens...
  63. ncbi Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis
    O J Cordero
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Santiago de Compostela, Galicia, Spain
    Rheumatol Int 21:69-74. 2001
    ..Although these data did not support our hypothesis, they support that interleukins not only initiate RA pathology but they can also participate in the maintenance of this immune response...
  64. pmc Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
    Joseph C Sun
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 183:2911-4. 2009
    ..Together, these findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common gamma signaling cytokines during their response against viral infection...
  65. ncbi Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2
    Sameek Roychowdhury
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:8062-7. 2004
    ....
  66. pmc Production and distribution of interleukin 15 and its receptors (IL-15Ralpha and IL-R2beta) in the implant interface tissues obtained during revision of failed total joint replacement
    S Saeed
    Osteoarticular Research Group and IRC in Biomedical Materials, Department of Histopathology, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK
    Int J Exp Pathol 82:201-9. 2001
    ..Finally, unlike IL-2, IL-15 plays a certain role in bone resorption that leads to failed joint prostheses. It is apparent that this cytokine is an important T cell mediated immune response which needs further research...
  67. ncbi APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signaling
    Cosimo Tortorella
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Clinica Medica II, Policlinico, 70124, Bari, Italy
    Mech Ageing Dev 123:1389-402. 2002
    ..Taken together, the data outline the role of CD28 and IL-12/IL-15 signaling impairment in T cell proliferative deficiency during senescence...
  68. ncbi Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels
    Michael Boyiadzis
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Biol Blood Marrow Transplant 14:290-300. 2008
    ....
  69. ncbi What does it take to make a natural killer?
    Francesco Colucci
    Cytokines and Lymphoid Development Unit, Department of Immunology, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
    Nat Rev Immunol 3:413-25. 2003
    ..An improved knowledge of NK-cell development in mice and humans might be useful to harness the power of these natural killers in the clinic to fight autoimmune diseases, infection and cancer...
  70. pmc IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
    Christopher A Klebanoff
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 101:1969-74. 2004
    ..These results provide several avenues for improving adoptive immunotherapy of cancer in patients...
  71. ncbi IL-15-independent proliferative renewal of memory CD8+ T cells in latent gammaherpesvirus infection
    Joshua J Obar
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 173:2705-14. 2004
    ..These data highlight fundamental differences between memory CD8(+) T cells engaged in active immune surveillance of latent viral infections vs memory CD8(+) T cells found after acute viral infections...
  72. ncbi IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
    Yvonne M Mueller
    Department of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Int Immunol 15:49-58. 2003
    ..These findings suggest that in addition to being a growth and survival factor for memory CD8(+) T cells, IL-15 is also a potent activator of human effector-memory CD8(+) T cells both in healthy and in HIV-infected individuals...
  73. ncbi Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils
    P P McDonald
    Department of General Pathology, University of Verona, Verona, Italy
    Blood 92:4828-35. 1998
    ....
  74. ncbi IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha
    R Pereno
    U506 INSERM Hôpital Paul Brousse 94807 Villejuif, France
    Oncogene 19:5153-62. 2000
    ..Thus, IL-15Ralpha controls NF-kappaB activation, however differences in the intracellular trafficking of the IL-15 and/or IL-15Ralpha suggest a different biological role for this complex in MELP versus MELREO cells...
  75. pmc Innate immune response of the human host to exposure with herpes simplex virus type 1: in vitro control of the virus infection by enhanced natural killer activity via interleukin-15 induction
    A Ahmad
    Laboratory of Immunovirology, Pediatric Research Center, Department of Microbiology, University of Montreal and Sainte Justine Hospital, Montreal, Quebec, Canada H3T 1C5
    J Virol 74:7196-203. 2000
    ..These results strongly suggest a role for IL-15 in the HSV-1-mediated in vitro enhancement of NK activity and in the PBMC-mediated suppression of HSV-1 replication...
  76. ncbi The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    T A Waldmann
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Annu Rev Immunol 17:19-49. 1999
    ..New approaches directed toward IL-15, its receptor, or its signaling pathway may be of value in the therapy of these disorders...
  77. pmc Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cells
    C De Giovanni
    Cancer Research Institute, University of Bologna, Italy
    Br J Cancer 78:1541-6. 1998
    We recently reported that rhabdomyosarcoma cell lines express and secrete interleukin 15 (IL-15), a tightly regulated cytokine with IL-2-like activity...
  78. pmc IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis
    SangKon Oh
    Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1578, USA
    Proc Natl Acad Sci U S A 105:5201-6. 2008
    ..These findings suggest new vaccine strategies against infections and cancers, especially in individuals with CD4-deficiency...
  79. pmc Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases
    Thomas A Waldmann
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 6:174-7. 2004
    ....
  80. ncbi Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice
    K Inagaki-Ohara
    Laboratory of Host Defense and Germfree Life, Nagoya University School of Medicine, Japan
    Eur J Immunol 27:2885-91. 1997
    ..This rescue was accompanied by up-regulation of Bcl-2 expression. These results suggest that IL-15 plays important roles in proliferation and maintenance of gamma delta i-IEL...
  81. ncbi Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes
    Subburaj Ilangumaran
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Immunol 171:2435-45. 2003
    ....
  82. pmc IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients
    N Azimi
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1374, USA
    Proc Natl Acad Sci U S A 98:14559-64. 2001
    ..This decrease was caused by both inhibition of proliferation and induction of apoptosis in these cells. The data indicate that IL-15 plays a major role in the maintenance of viral-specific CD8 cells in HAM/TSP...
  83. ncbi Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex
    J L de Jong
    Department of Human Oncology, University of Wisconsin, Madison 53792, USA
    J Immunol 156:1339-48. 1996
    ..This result was identical for both surface-iodinated YT cells and immunoprecipitates that were probed for IL-2R beta and IL-2R gamma c on Western blots...
  84. ncbi Interleukin 15: its role in inflammation and immunity
    L P Perera
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA
    Arch Immunol Ther Exp (Warsz) 48:457-64. 2000
    b>Interleukin 15 (IL-15) is a 14-15 kDa polypeptide that belongs to the 4 alpha-helix-bundle family of cytokines and was originally discovered due to its T cell proliferative activity...
  85. ncbi Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA
    H Nishimura
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan
    J Immunol 160:936-42. 1998
    ..These results suggest that normal IL-15 production in stimulated macrophages is regulated by splicing of alternative exon 5...
  86. pmc Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo
    N Oppenheimer-Marks
    Rheumatic Diseases Division of the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 8577, USA
    J Clin Invest 101:1261-72. 1998
    ..These results demonstrate that EC produce IL-15 and imply that endothelial IL-15 plays a critical role in stimulation of T cells to extravasate into inflammatory tissue...
  87. pmc Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    Joyce T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1523-32. 2002
    ..Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct...
  88. ncbi Interleukin 15-mediated induction of cytotoxic effector cells capable of eliminating Epstein-Barr virus-transformed/immortalized lymphocytes in culture
    E Sharif-Askari
    Laboratory of Immunovirology, Department of Microbiology and Immunology, and Pediatric Research Center, University of Montreal and Sainte-Justine Hospital, Montreal, PQ, Canada
    J Natl Cancer Inst 93:1724-32. 2001
    BACKGROUND: Interleukin 15 (IL-15) activates cytotoxic lymphocytes and drives the expansion of memory T cells. Its role in immune control of virus-transformed cells and other tumor cells remains to be elucidated...
  89. ncbi Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction
    Toshihiko Kawamura
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 171:5085-90. 2003
    ..These results indicate a novel role for IL-15Ralpha-chain in Ly-49 induction on developing NK cells...
  90. ncbi c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis
    Teresa Bianchi
    Ludwig Institute for Cancer Research LICR, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Blood 107:3992-9. 2006
    ..Collectively, our data identify c-Myc as a novel downstream component of the IL-15-dependent pathway controlling homeostatic proliferation of memory CD44(high) CD8 T cells...
  91. ncbi IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells
    I J Puzanov
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas 75235, USA
    J Immunol 157:4282-5. 1996
    ..1+ cells. mIL-15 also caused a greater expansion of NK1.1+CD3- cells as compared with NK1.1+CD3+ cells. We conclude that IL-15 is a specific maturation factor for NK cells and that it can mimic the marrow microenvironment in vitro...
  92. ncbi Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
    Tsunao Kishida
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Mol Ther 8:552-8. 2003
    ..These results strongly suggest that the codelivery of IL-21 and IL-15 elicits powerful antitumor immune responses, resulting in marked therapeutic efficacy against metastatic tumors...
  93. pmc Requirement for membrane lymphotoxin in natural killer cell development
    K Iizuka
    Departments of Internal Medicine and Pathology, Howard Hughes Medical Institute, and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:6336-40. 1999
    ..They also support a cellular and molecular mechanism by which NK cell precursors themselves deliver essential signals, through the membrane ligand, that induce the microenvironment to promote further NK cell and NK/T cell development...
  94. pmc High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission
    Jan Walter
    Children s Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
    J Infect Dis 200:1498-502. 2009
    Given the central role that interleukin 15 (IL-15) plays in human immunodeficiency virus (HIV) immunity, we hypothesized that IL-15 in breast milk may protect against postnatal HIV transmission...
  95. pmc Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo
    H Nishimura
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466, Japan
    J Exp Med 191:157-70. 2000
    ..Thus, two groups of IL-15 Tg mice may provide information concerning the different roles of IL-15 isoforms in the immune system in vivo...
  96. ncbi Interleukin 2 and interleukin 15 differentially predispose natural killer cells to apoptosis mediated by endothelial and tumour cells
    L Rodella
    Department of Biomedical Sciences and Biotechnologies, Division of Human Anatomy, University of Brescia, Italy
    Br J Haematol 115:442-50. 2001
    ..Once activated, T cells produce IL-2 that overcomes the effect of IL-15 on NK cells, paving the way for their death by apoptosis...
  97. ncbi Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaT
    Shoichiro Yano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Biochem Biophys Res Commun 301:841-7. 2003
    b>Interleukin 15 (IL-15) is a potent stimulator of proliferation and an inhibitor of apoptosis in lymphocytes. We attempted to elucidate the mechanism of IL-15 function in HaCaT keratinocytes...
  98. ncbi NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression
    T Musikacharoen
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 166:4516-24. 2001
    ..Thus, NF-kappa B activation is important but differently involved in the regulation of mTLR2 gene expression in macrophages and T cells following LPS or cytokine stimulation...
  99. ncbi The IL-15R alpha chain signals through association with Syk in human B cells
    E Bulanova
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 167:6292-302. 2001
    ....
  100. ncbi Chromosomal assignment and genomic structure of Il15
    D M Anderson
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Genomics 25:701-6. 1995
    ..Intron positions in a partial human IL15 genomic clone were identical with positions of corresponding introns in the murine gene. The human IL15 gene was mapped to human chromosome 4q31 by fluorescence in situ hybridization...
  101. pmc CD25+CD4+ T cells contribute to the control of memory CD8+ T cells
    Masaaki Murakami
    Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 99:8832-7. 2002
    ....

Research Grants63

  1. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..Their interactions with the blood-brain barrier largely determine the final outcome of these blood-borne cytokines. ..
  2. IMMUNOLOGY OF UNIQUE TUMOR SPECIFIC ANTIGENS
    Hans Schreiber; Fiscal Year: 2013
    ..With these antibodies, we will make additional CARs (and fusions proteins) to be used in combination with 5E5 to prevent tumor escape. ..
  3. IL-15 Characterization Through Experimental Immunology
    Michael A Caligiuri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interleukin 15 (IL-15) is a molecule that is highly relevant to natural killer (NK) cell development and homeostasis...
  4. The Toll-like receptor pathway in Meniscal Injury and Osteoarthritis
    CARLA ROSE SCANZELLO; Fiscal Year: 2013
    ..As we currently have no interventions for early OA that impact disease progression, defining important pathways in early disease is essential. ..
  5. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Understanding the mechanisms by which these factors enhance anti-viral immunity is essential to the development of novel strategies to delay onset and progression of HSV in at risk populations. ..
  6. Type 1 Diabetes Mouse Resource (T1DR)
    David V Serreze; Fiscal Year: 2012
    ..The mission of the T1DR is to import, re-derive to a high-level health status, curate, genotypically and phenotypically validate, cryopreserve, and distribute mouse stocks of value to the T1D research community. ..
  7. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma
    Hing C Wong; Fiscal Year: 2012
    ..Positive outcomes from this proposed study would provide justification for clinical development of this complex as a safe, durable, potent and cell-mediated immunotherapy to treat patients with multiple myeloma. ..
  8. Novel dominant-negative HSV-2 recombinant viral vaccines
    Feng Yao; Fiscal Year: 2011
    ..The vaccine efficacy of IL15/gB2-expressing CJ2-gD2 in preventing primary and recurrent HSV-2 genital disease will be evaluated in mouse and guinea pig models of HSV-2 intravaginal infection. ..
  9. Efficacy and safety of novel CD80 IL15 IL15Ra expressing autologous AML vaccines
    KARIN L GAENSLER; Fiscal Year: 2013
    ..Studies will directly inform the design of a Phase 1 clinical AML vaccine trial at UCSF for patients >60, ineligible for HSCT. ..
  10. Role of IL-15 in CD8 T Cell Development and Response
    Leo Lefrancois; Fiscal Year: 2011
    b>Interleukin 15 is an essential cytokine for maintenance of memory CD8 T cells and thus plays an important role in immune system homeostasis and in effective vaccination...
  11. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2013
    ..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..
  12. Immunity and the pathogenesis of abdominal aortic aneurysms
    JOHN HUNT LILLVIS; Fiscal Year: 2012
    ..abstract_text> ..
  13. T Cell Signaling in Rheumatoid Arthritis
    Jorg J Goronzy; Fiscal Year: 2013
    ..abstract_text> ..
  14. IL-15 receptor-alpha and IL-15 action in aging skeletal muscle and adipose tissue
    LeBris S Quinn; Fiscal Year: 2013
    ..These studies will provide mechanistic information which could be exploited pharmacologically to modulate body composition and the pathological consequences of sarcopenia and adiposity in the elderly. ..
  15. Modulation of liver fibrosis resolution by dendritic cells
    Costica Aloman; Fiscal Year: 2013
    ..These studies should uncover new pathways to accelerate fibrosis regression, leading to innovative treatments for patients with advanced fibrosis. ..
  16. Strategies to improve the adoptive transfer of T cells
    Stanley R Riddell; Fiscal Year: 2013
    ..that determine their fate in vivo and ability to establish durable T cell memory, and identified a role for interleukin 15 (IL-15) for supporting the long-term persistence of transferred T cells...
  17. Potentiating Natural Killer Cell Anti-Myeloma Effects
    Frits van Rhee; Fiscal Year: 2012
    ..This grant proposal describes 3 new ways in which the patient's own immune cells can be used to destroy the cancer. Such treatment may also be useful to treat other cancers. ..
  18. Growth Control in Multiple Myeloma
    Bart Barlogie; Fiscal Year: 2013
    ..This work will be accomplished with access to 5 shared resource cores. ..
  19. IN VITRO STIMULATION OF HIV SPECIFIC CD8+ T CELLS
    Peter D Katsikis; Fiscal Year: 2010
    ..b>Interleukin 15 (IL-15) we found can inhibit CD95/Fas- mediated apoptosis of HIV-specific CD8+ T cells and can restore the ..
  20. Genetic Mechanisms of Survivorship Disparities after Unrelated HCT
    Effie W Petersdorf; Fiscal Year: 2013
    ..The information will aid efforts to optimize transplant outcomes for AFA and API patients, while creating a highly novel and unique resource for continued investigation into the genetic basis of disease. ..
  21. Inducible B-regulatory cells (iBREGs) for treatment of Multiple Sclerosis
    Jacques Galipeau; Fiscal Year: 2013
    ..In sum, this study will enable us to pursue the characterization of iBregs and GIFT15 protein pharmacological product and will serve as rational for human clinical studies. ..
  22. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..Ultimately, this approach may provide a safer and more effective treatment for patients with cancer than the currently approved immunotherapies. ..
  23. Quantitative modeling of the phenotypic variability of individual T cells and the
    Gregoire Altan-Bonnet; Fiscal Year: 2012
    ..It consists in making and validating theoretical predictions to quantify and control how immune responses emerge as dynamically- and collectively-regulated properties of individual T cells. ..
  24. IL15 AND NATURAL KILLER (NK) CELL FUNCTION
    William Carson; Fiscal Year: 1999
    ....
  25. INTESTINAL CYTOKINES IN CRYPTOSPORIDIOSIS
    A White; Fiscal Year: 2005
    ..By contrast, naive, symptomatic individuals initially expressed Interleukin 15 (IL-15), which was associated with control of oocyst excretion...
  26. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  27. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Hayley Gans; Fiscal Year: 2009
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  28. Dendritic cell targeted hepatitis c virus immunotherapy
    Tyler Curiel; Fiscal Year: 2003
    ..that express and secrete DC-targeted NS3. A needle-less and non-toxic immunotherapy would provide a treatment for hepatitis C patients who currently have none. ..
  29. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2006
    ..abstract_text> ..
  30. An Anti-tumor Therapy Utilizing EP to Deliver IL-15 into B16.F10 Melanoma
    BERNADETTE MARRERO; Fiscal Year: 2010
    ..b>Interleukin 15 (IL-15) is a cytokine that activates natural killer (NK) cells and stimulates CD8+ T cells to exhibit long-..
  31. Role of T Cell Immunity in Primate AIDS
    Aftab Ansari; Fiscal Year: 2006
    ....
  32. Enhancing HIV-specific CD8+ T cells with IL-15.
    PETER KATSIKIS; Fiscal Year: 2005
    ..b>Interleukin 15 (IL-15) is a pluripotent cytokine that expands in vivo memory CD8+ T cells, enhances their survival, and ..
  33. Active Immune Therapy and HAART for HIV-1 Infection
    David Weiner; Fiscal Year: 2009
    ..Another parallel trial, conducted by the HVTN will test these products in HIV uninfected individuals. ..
  34. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..abstract_text> ..
  35. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  36. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  37. Natural Killer Cell Mediated Control of Vaccinia Virus
    Anthony French; Fiscal Year: 2007
    ..The proposed work will occur under the mentorship of Dr. Wayne Yokoyama a recognized pioneer in the NK cell field who has successfully trained numerous graduate students and postdoctoral fellows. [unreadable] [unreadable]..
  38. THYMUS AND CENTRAL TOLERANCE
    Jonathan Sprent; Fiscal Year: 2003
    ..Resolving these questions will shed light on the basic mechanisms involved in self/non-self discrimination, the induction of autoimmune disease and the immune responses to neoplastic cells. ..
  39. T CELL TURNOVER AND THE ROLE OF CYTOKINES
    Jonathan Sprent; Fiscal Year: 2004
    ....
  40. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  41. T Cell Expansion and Colitis in Immunodeficient Mice
    Charles Surh; Fiscal Year: 2009
    ..Third, cellular mechanisms involved in regulating potentially pathogenic CD4 cells will be better defined. Results from these investigations may be useful in designing better approaches for preventing or treating IBDs in humans. ..
  42. REGULATION OF T CELL HOMEOSTASIS AND SURVIVAL
    Charles Surh; Fiscal Year: 2009
    ..The findings from these studies are likely to have important implications for the design of vaccines and therapies for treatment of immunodeficiencies and cancer. ..
  43. Homeostasis of Mature T Cells in the Aged
    Charles Surh; Fiscal Year: 2005
    ..Third, the possibility of restoring the naive T cell pool in old mice through manipulation of the homeostatic factors will be tested. ..
  44. Regulation of normal human IEL by NKG2D and IL-15
    Bana Jabri; Fiscal Year: 2010
    ....
  45. Correlative Studies for Phase II Trial of IL12 and IFNa
    William Carson; Fiscal Year: 2002
    ..This series of experiments will permit us to evaluate the patient response to cytokine therapy at the cellular and molecular levels and identify key determinants of cytokine responsiveness. ..
  46. CD4 T Cell Activation in SIV+Disease Resistant Mangabeys
    Aftab Ansari; Fiscal Year: 2004
    ..abstract_text> ..
  47. LETHAL OROESOPHAGEAL CANDIDIASIS: IMMUNOTHERAPY
    Edward Balish; Fiscal Year: 2004
    ..Restoration and enhancement of immune function may be critical for the effectiveness of anti-Candida vaccines that are now under development. ..
  48. ELECTROCHEMOTHERAPY FOR TREATING SOFT TISSUE SARCOMAS
    Richard Heller; Fiscal Year: 2002
    ..An important consideration in the treatment of soft tissue sarcoma is to be able to perform limb sparing procedures which maintain functionality. ECT combined with surgery could fill this role. ..
  49. HIV INFECTION/COCAINE EFFECT ON CARDIOVASCULAR PATHOLOGY
    Aftab Ansari; Fiscal Year: 2003
    ..We reason that such studies may provide unique insights on the relationship between the effects of cocaine and HIV infection in the pathogenesis of cardiovascular disease. ..
  50. DETECTION OF IMMUNOGENIC OVARIAN CANCER ANTIGENS
    Marcus Butler; Fiscal Year: 2005
    ..Butler will receive from his mentor, as well as his collaborators, will enable Dr. Butler to mature into a leading clinician-scientist interested in translating breakthroughs in immunotherapy to the care of patients. ..
  51. THERAPEUTIC RESPONSE IN LGL LEUKEMIA
    Thomas Loughran; Fiscal Year: 2005
    ..Treatment effects on expression of STAT-regulated genes will be examined using microarray analyses. Results of these studies should identify important molecular targets for drug development in hematologic malignancies. ..
  52. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
  54. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2010
    ..The focus of the present proposal is to understand how this signaling pathway in DCs, regulates inflammation, immunological tolerance and vaccine induced immunity. ..
  55. In vivo significance of T-reg cells during FIV infection
    Gregg Dean; Fiscal Year: 2006
    ..Results from these studies will provide a clinical understanding of Treg function in HIV infection and will guide future approaches to modulate Treg function. ..
  56. Cytokine Polymorphisms and Hodgkin Lymphoma Risk
    Wendy Cozen; Fiscal Year: 2006
    ..This study is important since it may will lead to identification of causal genetic factors which may offer alternative therapeutic strategies or prevention. ..
  57. Caloric restrictions and immune senescence
    Janko Nikolich Zugich; Fiscal Year: 2006
    ..This will not only test the validity of observations in rodents, but also put limits on current hypotheses and allow for the rational setting of new ones. ..
  58. Therapy of Melanoma with Bortezomib and Interferon-alpha
    William Carson; Fiscal Year: 2007
    ..These studies will help to define the specific apoptotic and immunostimulatory pathways that are being modulated by the combination of bortezomib and IFN-a2b. [unreadable] [unreadable]..
  59. Differential cytokine responses in Hep C patients.
    Milton Taylor; Fiscal Year: 2005
    ..We will attempt to establish an in vitro system that mimics in vivo events. This combination of experiments should identify factors that are important in the differential responses to treatment and viral resistance. ..
  60. MOLECULAR MECHANISMS OF CD4+ T CELL DYSFUNCTION IN SIV
    Aftab Ansari; Fiscal Year: 2009
    ..abstract_text> ..
  61. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    AVERIL I MA; Fiscal Year: 2010
    ..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..