Genomes and Genes
Summary: Cytokine that stimulates the proliferation of T-lymphocytes and shares biological activities with IL-2. IL-15 also can induce B-lymphocyte proliferation and differentiation.
Publications303 found, 100 shown here
- IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2J G Giri
Immunex Research and Development Corporation, Seattle, WA 98101, USA
J Leukoc Biol 57:763-6. 1995b>Interleukin 15 is a newly discovered cytokine that shares biological activities with IL-2 and, like IL-2, is a member of the four-helix bundle cytokine family...
- Cytokine control of memory T-cell development and survivalKimberly S Schluns
Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 1319, USA
Nat Rev Immunol 3:269-79. 2003..In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained...
- Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceM K Kennedy
Immunex Corporation, Seattle, Washington 98101, USA
J Exp Med 191:771-80. 2000C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting...
- The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine designThomas A Waldmann
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 6:595-601. 2006..As discussed in this Review, the biology of these cytokines will affect the development of novel therapies for malignancy and autoimmune diseases, as well as the design of vaccines against infectious diseases...
- IL-15 trans-presentation promotes human NK cell development and differentiation in vivoNicholas D Huntington
Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
J Exp Med 206:25-34. 2009....
- IL-15Ralpha recycles and presents IL-15 In trans to neighboring cellsSigrid Dubois
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 17:537-47. 2002..Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8(+) T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction...
- IL-15/IL-15 receptor biology: a guided tour through an expanding universeVadim Budagian
Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
Cytokine Growth Factor Rev 17:259-80. 2006..Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance...
- Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivoThomas A Stoklasek
Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
J Immunol 177:6072-80. 2006..These findings hold significant importance for the use of IL-15 as a potential adjuvant/therapeutic and inducer of homeostatic proliferation, without the necessity for prior immunodepletion...
- Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAsTodd A Fehniger
Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Immunity 26:798-811. 2007..These data suggest that resting murine NK cells are minimally cytotoxic because of a block in perforin and granzyme B mRNA translation that is released by NK cell activation...
- Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptidesD Bernardo
Gut 56:889-90. 2007
- Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionKhuong B Nguyen
Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Immunol 169:4279-87. 2002....
- Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac diseaseJean Jacques Mention
INSERM EMI 0212, Faculte Necker, Paris
Gastroenterology 125:730-45. 2003....
- Interleukin-21 inhibits dendritic cell activation and maturationKatja Brandt
Research Center Borstel, Dept of Immunology and Cell Biology, Parkallee 22, 23845 Borstel, Germany
Blood 102:4090-8. 2003....
- Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expressionS Dubois
Groupe de Recherche Cytokines et Récepteurs, Unité INSERM 463, Institut de Biologie, 9 quai Moncousu, 44035 Nantes Cedex 01, France
J Biol Chem 274:26978-84. 1999..Together, our data indicate that exon 2 splicing of human IL-15Ralpha is a natural process that might play regulatory roles at different levels...
- Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptorJ G Giri
Immunex Research and Development Corporation, Seattle, WA 98101, USA
EMBO J 14:3654-63. 1995..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2...
- Prognostic value of interleukin 2 and interleukin 15 in peritumoral hepatic tissues for patients with hepatitis B-related hepatocellular carcinoma after curative resectionHaijun Zhou
Liver Cancer Institute and Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China
Gut 59:1699-708. 2010..This study evaluated the prognostic values of intratumoral and peritumoral Th1/Th2 cytokine protein levels in patients with HCC after curative resection...
- The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivoM Orchardson
Department of Immunology and Bacteriology and Center of Rheumatic Disease, University of Glasgow, Glasgow, United Kingdom
J Immunol 167:277-82. 2001..Thus, the Sushi domain is critical for the functional activity of sIL-15Ralpha...
- Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cellsAdam D Judge
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 196:935-46. 2002..Thus, subsets of memory-phenotype T cells differ radically in their sensitivity to IL-15...
- Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophagesJanice J Endsley
Department of Pediatrics, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
J Leukoc Biol 79:71-9. 2006..These NK cell receptors bearing T lymphocytes may represent memory subsets characterized in humans. The results of these studies demonstrate that bovine NK cells may play an important role in the innate immune responses of cattle...
- Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cellsTodd C Becker
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Exp Med 195:1541-8. 2002..Taken together, these results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time...
- Safety and immunologic effects of IL-15 administration in nonhuman primatesCarolina Berger
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Blood 114:2417-26. 2009..These findings demonstrate that IL-15 has profound immunomodulatory properties distinct from those described for IL-2, and suggest that intermittent administration of IL-15 should be considered in clinical studies...
- IL-15 is an essential mediator of peripheral NK-cell homeostasisThomas Ranson
Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
Blood 101:4887-93. 2003..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells...
- Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac diseaseBertrand Meresse
Department of Pathology, University of Chicago, IL 60637, USA
Immunity 21:357-66. 2004....
- Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptidesY Tagaya
Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:14444-9. 1997Two isoforms of human interleukin 15 (IL-15) exist...
- Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillanceHisataka Kobayashi
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 105:721-7. 2005b>Interleukin 15 (IL-15) is a critical factor for the proliferation and activation of natural killer (NK) and CD8 T cells...
- IL-15 promotes the survival of naive and memory phenotype CD8+ T cellsMarion Berard
Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
J Immunol 170:5018-26. 2003..These results show that IL-15 has multiple effects on CD8 T cells and possesses the potential to regulate the life span of naive as well as memory CD8(+) T cells...
- Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1Nicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Immunol 8:856-63. 2007b>Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we identify Bim, Noxa and Mcl-1 as key regulators of IL-15-dependent survival of NK cells...
- Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in transMami Chirifu
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
Nat Immunol 8:1001-7. 2007b>Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share beta- and gamma-signaling subunits...
- Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15J G Giri
Immunex Research and Development Corporation, Seattle, WA 98101
EMBO J 13:2822-30. 1994..The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component...
- IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cellsMari Strengell
Department of Microbiology, National Public Health Institute, Helsinki, Finland
J Immunol 170:5464-9. 2003..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response...
- NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironmentA I Roberts
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
J Immunol 167:5527-30. 2001..Uncontrolled secretion of IL-15 could lead to excessive induction of NKG2D and thus contribute to the development of autoimmune disease by facilitating the activation of autoreactive T cells...
- Differential regulation of T-cell growth by IL-2 and IL-15Georgina H Cornish
Cancer Research UK, London, England
Blood 108:600-8. 2006..Hence, the present results show that cytokines that are equivalent mitogens can have different potency in terms of regulating protein synthesis and cell growth...
- A direct role for NKG2D/MICA interaction in villous atrophy during celiac diseaseSophie Hue
Equipe Avenir Inserm, Hopital Necker Enfants Malades, 75015 Paris, France
Immunity 21:367-77. 2004..This supports a key role for MIC/NKG2D in the activation of intraepithelial immunity in response to danger...
- Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptorN Azimi
Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
J Immunol 163:4064-72. 1999..These data suggest the existence of two autocrine loops involving IL-15/IL-15R and IL-2/IL-2R, both contributing to the spontaneous proliferation of HAM/TSP PBMC...
- IL-15 expression at human endometrium and deciduaK Kitaya
Department of Obstetrics and Gynecology and Dynamic Pathology Research Institute, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
Biol Reprod 63:683-7. 2000..These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone...
- IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responsesYvonne M Mueller
Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USA
J Immunol 180:350-60. 2008..Finally, IL-15-treated acutely SIV-infected primates may serve as a useful model to investigate the poorly understood mechanisms that control viral set point and disease progression in HIV infection...
- IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitroWanda Niedbala
Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, Scotland, GB
Eur J Immunol 32:341-7. 2002b>Interleukin 15 (IL-15) is a pleiotropic cytokine produced principally by monocytes and affects both innate and acquired immunity...
- The growth of the very large CD8+ T cell clones in older mice is controlled by cytokinesC C Ku
Howard Hughes Medical Institute, Department of Immunology, National Jewish Medical and Research Center, University of Colorado Medical School, Denver, CO 80207, USA
J Immunol 166:2186-93. 2001..Thus they might affect the immune response of their hosts by competing for factors that stimulate and inhibit normal CD8(+) memory T cells...
- IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21Adrianna Moroz
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Immunol 173:900-9. 2004..These findings indicate that the mechanisms used by IL-21 to promote CD8(+) T cell responses offer unique opportunities for its use in malignant diseases and infections...
- SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potentialGayle M Davey
The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
J Exp Med 202:1099-108. 2005..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice...
- IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferationAnthony R French
Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, Box 8208, 660 South Euclid Ave, St Louis, MO 63110, USA
Cytokine 35:229-34. 2006..This raises the possibility that IL-18 may act synergistically with IL-15 in driving pathogen-induced NK cell proliferation in addition to its contribution in enhancing IL-12 stimulation of NK cell IFNgamma production...
- Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genesD M Anderson
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 270:29862-9. 1995..However, the distribution of expression of the IL-15R alpha is much wider than that of the IL-2R alpha, suggesting a broader range of cellular targets for IL-15...
- How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alphaErwin H Duitman
Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
Mol Cell Biol 28:4851-61. 2008....
- Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse modelLouise S Villadsen
Department of Dermatology, Gentofte University Hospital, Copenhagen, Denmark
J Clin Invest 112:1571-80. 2003..These results obtained with this IL-15-specific mAb support an important role for IL-15 in the pathogenesis of psoriasis...
- Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cellsT A Fehniger
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
J Exp Med 193:219-31. 2001..Later, these mice develop fatal lymphocytic leukemia with a T-NK phenotype. These data provide novel evidence that leukemia, like certain other cancers, can arise as the result of chronic stimulation by a proinflammatory cytokine...
- CD69 expression on lymphocytes and interleukin-15 levels in synovial fluids from different inflammatory arthropathiesAna M Ortiz
Rheumatology Department, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
Rheumatol Int 21:182-8. 2002..The aim was to study a possible relationship between CD69 expression on lymphocytes and interleukin-15 (IL-15) levels in synovial fluid (SF) from patients with different inflammatory arthropathies...
- IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaquesF Villinger
Department of Pathology and Laboratory Medicine, Emory University, Woodruff Memorial Building 2339, 1639 Pierce Drive, Atlanta, GA 30322, USA
Vaccine 22:3510-21. 2004..Following booster immunization, however, only IL-15 appeared able to enhance CD8 T cell responses while IL-2 or IL2/IL-15 administration were less effective...
- Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competenceSimona Cavalieri
Institute for Cancer Research and Treatment, University of Torino Medical School, Cadiolo Torino, Italy
Blood 102:497-505. 2003..Thus, LV transduction of IL-2 or IL-7 prestimulated cells overcomes the limitations of retroviral vectors and may significantly improve the efficacy of T-cell-based gene therapy...
- Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2John J Zaunders
Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
J Infect Dis 187:1735-47. 2003..Understanding cytokine effects on CCR5(+) T cells will be important in understanding chronic HIV-1 replication and pathogenesis...
- Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responsesAlicia R Mathers
Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Immunol 182:921-33. 2009..Overall, our data demonstrate that human epidermal smiLCs induce Th17 responses by mechanisms different from those previously described and highlight the need to target clinical treatments based on these variations...
- Intestinal epithelial cells both express and respond to interleukin 15H C Reinecker
Department of Medicine, Massachusetts General Hospital, Boston, USA
Gastroenterology 111:1706-13. 1996..The aim of this study was to characterize the expression of IL-15 by intestinal epithelial cells and determine the functional roles of IL-15 within the mucosal immune system...
- Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical diseaseF Abebe
University of Oslo, Institute of General Practice and Community Medicine, Section for International Health, Oslo, Norway
Clin Exp Immunol 143:180-92. 2006..Our results, together with the above observations, suggest that IL-15 may play an important role in mediating active disease during Mtb infection...
- Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cellsH Yoshida
Department of Molecular Genetics, Graduate School of Medicine, and Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo, Kyoto, Japan
J Immunol 167:2511-21. 2001....
- Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expressionKimberly S Schluns
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Proc Natl Acad Sci U S A 101:5616-21. 2004..These results demonstrated dichotomous mechanisms by which IL-15 regulated lymphoid development, interacting with distinct cell types depending on the developmental pathway...
- Dendritic cells prime natural killer cells by trans-presenting interleukin 15Mathias Lucas
Skirball Institute of Biomolecular Medicine, Program in Molecular Pathogenesis, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 26:503-17. 2007..Our data define a unique in vivo role of DCs for the priming of NK cells, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system...
- A regulatory role of interleukin 15 in wound healing and mucosal infection in miceYoshiko Kagimoto
Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Leukoc Biol 83:165-72. 2008..Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-beta1, promoting wound healing but impeding protection against genital HSV-2 infection...
- Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptorK H Grabstein
Immunex Research and Development Corporation, Seattle, WA 98101
Science 264:965-8. 1994..Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor...
- The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15G Kurys
Metabolism Branch, NCI, National Institutes of Health and the Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1374, USA
J Biol Chem 275:30653-9. 2000..In terms of a more positive role, we propose that intracellular infection may relieve the burdens on translation and intracellular trafficking to yield effective IL-15 expression...
- Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activationSeiichi Kuwajima
Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
Nat Immunol 7:740-6. 2006The function of interleukin 15 (IL-15) in unmethylated CpG oligodeoxynucleotide (CpG)-induced immune responses remains unknown...
- Expression of interleukin-15 in mouse and human atherosclerotic lesionsD M Wuttge
Department of Medicine, Karolinska Hospital, Karolinska Institute, S 171 76 Stockholm, Sweden
Am J Pathol 159:417-23. 2001..In conclusion, IL-15 is up-regulated in both human and animal atherosclerotic lesions and may contribute to the recruitment of T cells and their activation during atherogenesis...
- Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokinesWai Kan Chiu
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Immunol 177:7802-10. 2006....
- IL-15-induced conversion of monocytes to mature dendritic cellsK U Saikh
Laboratory of Molecular Immunology, Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
Clin Exp Immunol 126:447-55. 2001..Thus, the release of IL-15 by inflammatory stimuli may induce the conversion of monocytes to immuno-stimulatory dendritic cells to support primary immune responses against pathogens...
- Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritisO J Cordero
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Santiago de Compostela, Galicia, Spain
Rheumatol Int 21:69-74. 2001..Although these data did not support our hypothesis, they support that interleukins not only initiate RA pathology but they can also participate in the maintenance of this immune response...
- Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infectionJoseph C Sun
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
J Immunol 183:2911-4. 2009..Together, these findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common gamma signaling cytokines during their response against viral infection...
- Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2Sameek Roychowdhury
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 64:8062-7. 2004....
- Production and distribution of interleukin 15 and its receptors (IL-15Ralpha and IL-R2beta) in the implant interface tissues obtained during revision of failed total joint replacementS Saeed
Osteoarticular Research Group and IRC in Biomedical Materials, Department of Histopathology, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK
Int J Exp Pathol 82:201-9. 2001..Finally, unlike IL-2, IL-15 plays a certain role in bone resorption that leads to failed joint prostheses. It is apparent that this cytokine is an important T cell mediated immune response which needs further research...
- APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signalingCosimo Tortorella
Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Clinica Medica II, Policlinico, 70124, Bari, Italy
Mech Ageing Dev 123:1389-402. 2002..Taken together, the data outline the role of CD28 and IL-12/IL-15 signaling impairment in T cell proliferative deficiency during senescence...
- Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levelsMichael Boyiadzis
Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Biol Blood Marrow Transplant 14:290-300. 2008....
- What does it take to make a natural killer?Francesco Colucci
Cytokines and Lymphoid Development Unit, Department of Immunology, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
Nat Rev Immunol 3:413-25. 2003..An improved knowledge of NK-cell development in mice and humans might be useful to harness the power of these natural killers in the clinic to fight autoimmune diseases, infection and cancer...
- IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cellsChristopher A Klebanoff
Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 101:1969-74. 2004..These results provide several avenues for improving adoptive immunotherapy of cancer in patients...
- IL-15-independent proliferative renewal of memory CD8+ T cells in latent gammaherpesvirus infectionJoshua J Obar
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 173:2705-14. 2004..These data highlight fundamental differences between memory CD8(+) T cells engaged in active immune surveillance of latent viral infections vs memory CD8(+) T cells found after acute viral infections...
- IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cellsYvonne M Mueller
Department of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA
Int Immunol 15:49-58. 2003..These findings suggest that in addition to being a growth and survival factor for memory CD8(+) T cells, IL-15 is also a potent activator of human effector-memory CD8(+) T cells both in healthy and in HIV-infected individuals...
- Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophilsP P McDonald
Department of General Pathology, University of Verona, Verona, Italy
Blood 92:4828-35. 1998....
- IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15RalphaR Pereno
U506 INSERM Hôpital Paul Brousse 94807 Villejuif, France
Oncogene 19:5153-62. 2000..Thus, IL-15Ralpha controls NF-kappaB activation, however differences in the intracellular trafficking of the IL-15 and/or IL-15Ralpha suggest a different biological role for this complex in MELP versus MELREO cells...
- Innate immune response of the human host to exposure with herpes simplex virus type 1: in vitro control of the virus infection by enhanced natural killer activity via interleukin-15 inductionA Ahmad
Laboratory of Immunovirology, Pediatric Research Center, Department of Microbiology, University of Montreal and Sainte Justine Hospital, Montreal, Quebec, Canada H3T 1C5
J Virol 74:7196-203. 2000..These results strongly suggest a role for IL-15 in the HSV-1-mediated in vitro enhancement of NK activity and in the PBMC-mediated suppression of HSV-1 replication...
- The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogensT A Waldmann
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Annu Rev Immunol 17:19-49. 1999..New approaches directed toward IL-15, its receptor, or its signaling pathway may be of value in the therapy of these disorders...
- Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cellsC De Giovanni
Cancer Research Institute, University of Bologna, Italy
Br J Cancer 78:1541-6. 1998We recently reported that rhabdomyosarcoma cell lines express and secrete interleukin 15 (IL-15), a tightly regulated cytokine with IL-2-like activity...
- IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosisSangKon Oh
Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1578, USA
Proc Natl Acad Sci U S A 105:5201-6. 2008..These findings suggest new vaccine strategies against infections and cancers, especially in individuals with CD4-deficiency...
- Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseasesThomas A Waldmann
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Res Ther 6:174-7. 2004....
- Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in miceK Inagaki-Ohara
Laboratory of Host Defense and Germfree Life, Nagoya University School of Medicine, Japan
Eur J Immunol 27:2885-91. 1997..This rescue was accompanied by up-regulation of Bcl-2 expression. These results suggest that IL-15 plays important roles in proliferation and maintenance of gamma delta i-IEL...
- Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytesSubburaj Ilangumaran
Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
J Immunol 171:2435-45. 2003....
- IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patientsN Azimi
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1374, USA
Proc Natl Acad Sci U S A 98:14559-64. 2001..This decrease was caused by both inhibition of proliferation and induction of apoptosis in these cells. The data indicate that IL-15 plays a major role in the maintenance of viral-specific CD8 cells in HAM/TSP...
- Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complexJ L de Jong
Department of Human Oncology, University of Wisconsin, Madison 53792, USA
J Immunol 156:1339-48. 1996..This result was identical for both surface-iodinated YT cells and immunoprecipitates that were probed for IL-2R beta and IL-2R gamma c on Western blots...
- Interleukin 15: its role in inflammation and immunityL P Perera
Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA
Arch Immunol Ther Exp (Warsz) 48:457-64. 2000b>Interleukin 15 (IL-15) is a 14-15 kDa polypeptide that belongs to the 4 alpha-helix-bundle family of cytokines and was originally discovered due to its T cell proliferative activity...
- Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNAH Nishimura
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan
J Immunol 160:936-42. 1998..These results suggest that normal IL-15 production in stimulated macrophages is regulated by splicing of alternative exon 5...
- Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivoN Oppenheimer-Marks
Rheumatic Diseases Division of the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 8577, USA
J Clin Invest 101:1261-72. 1998..These results demonstrate that EC produce IL-15 and imply that endothelial IL-15 plays a critical role in stimulation of T cells to extravasate into inflammatory tissue...
- Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cellsJoyce T Tan
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 195:1523-32. 2002..Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct...
- Interleukin 15-mediated induction of cytotoxic effector cells capable of eliminating Epstein-Barr virus-transformed/immortalized lymphocytes in cultureE Sharif-Askari
Laboratory of Immunovirology, Department of Microbiology and Immunology, and Pediatric Research Center, University of Montreal and Sainte-Justine Hospital, Montreal, PQ, Canada
J Natl Cancer Inst 93:1724-32. 2001BACKGROUND: Interleukin 15 (IL-15) activates cytotoxic lymphocytes and drives the expansion of memory T cells. Its role in immune control of virus-transformed cells and other tumor cells remains to be elucidated...
- Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 inductionToshihiko Kawamura
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
J Immunol 171:5085-90. 2003..These results indicate a novel role for IL-15Ralpha-chain in Ly-49 induction on developing NK cells...
- c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasisTeresa Bianchi
Ludwig Institute for Cancer Research LICR, Ch des Boveresses 155, 1066 Epalinges, Switzerland
Blood 107:3992-9. 2006..Collectively, our data identify c-Myc as a novel downstream component of the IL-15-dependent pathway controlling homeostatic proliferation of memory CD44(high) CD8 T cells...
- IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cellsI J Puzanov
Department of Pathology, University of Texas Southwestern Medical Center at Dallas 75235, USA
J Immunol 157:4282-5. 1996..1+ cells. mIL-15 also caused a greater expansion of NK1.1+CD3- cells as compared with NK1.1+CD3+ cells. We conclude that IL-15 is a specific maturation factor for NK cells and that it can mimic the marrow microenvironment in vitro...
- Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphomaTsunao Kishida
Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Mol Ther 8:552-8. 2003..These results strongly suggest that the codelivery of IL-21 and IL-15 elicits powerful antitumor immune responses, resulting in marked therapeutic efficacy against metastatic tumors...
- Requirement for membrane lymphotoxin in natural killer cell developmentK Iizuka
Departments of Internal Medicine and Pathology, Howard Hughes Medical Institute, and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:6336-40. 1999..They also support a cellular and molecular mechanism by which NK cell precursors themselves deliver essential signals, through the membrane ligand, that induce the microenvironment to promote further NK cell and NK/T cell development...
- High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmissionJan Walter
Children s Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
J Infect Dis 200:1498-502. 2009Given the central role that interleukin 15 (IL-15) plays in human immunodeficiency virus (HIV) immunity, we hypothesized that IL-15 in breast milk may protect against postnatal HIV transmission...
- Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivoH Nishimura
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466, Japan
J Exp Med 191:157-70. 2000..Thus, two groups of IL-15 Tg mice may provide information concerning the different roles of IL-15 isoforms in the immune system in vivo...
- Interleukin 2 and interleukin 15 differentially predispose natural killer cells to apoptosis mediated by endothelial and tumour cellsL Rodella
Department of Biomedical Sciences and Biotechnologies, Division of Human Anatomy, University of Brescia, Italy
Br J Haematol 115:442-50. 2001..Once activated, T cells produce IL-2 that overcomes the effect of IL-15 on NK cells, paving the way for their death by apoptosis...
- Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaTShoichiro Yano
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
Biochem Biophys Res Commun 301:841-7. 2003b>Interleukin 15 (IL-15) is a potent stimulator of proliferation and an inhibitor of apoptosis in lymphocytes. We attempted to elucidate the mechanism of IL-15 function in HaCaT keratinocytes...
- NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expressionT Musikacharoen
Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
J Immunol 166:4516-24. 2001..Thus, NF-kappa B activation is important but differently involved in the regulation of mTLR2 gene expression in macrophages and T cells following LPS or cytokine stimulation...
- The IL-15R alpha chain signals through association with Syk in human B cellsE Bulanova
Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
J Immunol 167:6292-302. 2001....
- Chromosomal assignment and genomic structure of Il15D M Anderson
Immunex Research and Development Corporation, Seattle, Washington 98101, USA
Genomics 25:701-6. 1995..Intron positions in a partial human IL15 genomic clone were identical with positions of corresponding introns in the murine gene. The human IL15 gene was mapped to human chromosome 4q31 by fluorescence in situ hybridization...
- CD25+CD4+ T cells contribute to the control of memory CD8+ T cellsMasaaki Murakami
Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and University of Colorado Health Sciences Center, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 99:8832-7. 2002....
- Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNFWeihong Pan; Fiscal Year: 2012..Their interactions with the blood-brain barrier largely determine the final outcome of these blood-borne cytokines. ..
- IMMUNOLOGY OF UNIQUE TUMOR SPECIFIC ANTIGENSHans Schreiber; Fiscal Year: 2013..With these antibodies, we will make additional CARs (and fusions proteins) to be used in combination with 5E5 to prevent tumor escape. ..
- IL-15 Characterization Through Experimental ImmunologyMichael A Caligiuri; Fiscal Year: 2013DESCRIPTION (provided by applicant): Interleukin 15 (IL-15) is a molecule that is highly relevant to natural killer (NK) cell development and homeostasis...
- The Toll-like receptor pathway in Meniscal Injury and OsteoarthritisCARLA ROSE SCANZELLO; Fiscal Year: 2013..As we currently have no interventions for early OA that impact disease progression, defining important pathways in early disease is essential. ..
- Microenvironmental changes on NK cell responses to primary HSV-1Andrew J Tarr; Fiscal Year: 2011..Understanding the mechanisms by which these factors enhance anti-viral immunity is essential to the development of novel strategies to delay onset and progression of HSV in at risk populations. ..
- Type 1 Diabetes Mouse Resource (T1DR)David V Serreze; Fiscal Year: 2012..The mission of the T1DR is to import, re-derive to a high-level health status, curate, genotypically and phenotypically validate, cryopreserve, and distribute mouse stocks of value to the T1D research community. ..
- IL-15 Superagonist Complex as an Immunotherapeutic for Multiple MyelomaHing C Wong; Fiscal Year: 2012..Positive outcomes from this proposed study would provide justification for clinical development of this complex as a safe, durable, potent and cell-mediated immunotherapy to treat patients with multiple myeloma. ..
- Novel dominant-negative HSV-2 recombinant viral vaccinesFeng Yao; Fiscal Year: 2011..The vaccine efficacy of IL15/gB2-expressing CJ2-gD2 in preventing primary and recurrent HSV-2 genital disease will be evaluated in mouse and guinea pig models of HSV-2 intravaginal infection. ..
- Efficacy and safety of novel CD80 IL15 IL15Ra expressing autologous AML vaccinesKARIN L GAENSLER; Fiscal Year: 2013..Studies will directly inform the design of a Phase 1 clinical AML vaccine trial at UCSF for patients >60, ineligible for HSCT. ..
- Role of IL-15 in CD8 T Cell Development and ResponseLeo Lefrancois; Fiscal Year: 2011b>Interleukin 15 is an essential cytokine for maintenance of memory CD8 T cells and thus plays an important role in immune system homeostasis and in effective vaccination...
- Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T CellsAnna Karolina Palucka; Fiscal Year: 2013..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..
- Immunity and the pathogenesis of abdominal aortic aneurysmsJOHN HUNT LILLVIS; Fiscal Year: 2012..abstract_text> ..
- T Cell Signaling in Rheumatoid ArthritisJorg J Goronzy; Fiscal Year: 2013..abstract_text> ..
- IL-15 receptor-alpha and IL-15 action in aging skeletal muscle and adipose tissueLeBris S Quinn; Fiscal Year: 2013..These studies will provide mechanistic information which could be exploited pharmacologically to modulate body composition and the pathological consequences of sarcopenia and adiposity in the elderly. ..
- Modulation of liver fibrosis resolution by dendritic cellsCostica Aloman; Fiscal Year: 2013..These studies should uncover new pathways to accelerate fibrosis regression, leading to innovative treatments for patients with advanced fibrosis. ..
- Strategies to improve the adoptive transfer of T cellsStanley R Riddell; Fiscal Year: 2013..that determine their fate in vivo and ability to establish durable T cell memory, and identified a role for interleukin 15 (IL-15) for supporting the long-term persistence of transferred T cells...
- Potentiating Natural Killer Cell Anti-Myeloma EffectsFrits van Rhee; Fiscal Year: 2012..This grant proposal describes 3 new ways in which the patient's own immune cells can be used to destroy the cancer. Such treatment may also be useful to treat other cancers. ..
- Growth Control in Multiple MyelomaBart Barlogie; Fiscal Year: 2013..This work will be accomplished with access to 5 shared resource cores. ..
- IN VITRO STIMULATION OF HIV SPECIFIC CD8+ T CELLSPeter D Katsikis; Fiscal Year: 2010..b>Interleukin 15 (IL-15) we found can inhibit CD95/Fas- mediated apoptosis of HIV-specific CD8+ T cells and can restore the ..
- Genetic Mechanisms of Survivorship Disparities after Unrelated HCTEffie W Petersdorf; Fiscal Year: 2013..The information will aid efforts to optimize transplant outcomes for AFA and API patients, while creating a highly novel and unique resource for continued investigation into the genetic basis of disease. ..
- Inducible B-regulatory cells (iBREGs) for treatment of Multiple SclerosisJacques Galipeau; Fiscal Year: 2013..In sum, this study will enable us to pursue the characterization of iBregs and GIFT15 protein pharmacological product and will serve as rational for human clinical studies. ..
- Soluble TCR-IL15 Fusions as Targeted Therapeutics for CancerPeter Rhode; Fiscal Year: 2009..Ultimately, this approach may provide a safer and more effective treatment for patients with cancer than the currently approved immunotherapies. ..
- Quantitative modeling of the phenotypic variability of individual T cells and theGregoire Altan-Bonnet; Fiscal Year: 2012..It consists in making and validating theoretical predictions to quantify and control how immune responses emerge as dynamically- and collectively-regulated properties of individual T cells. ..
- IL15 AND NATURAL KILLER (NK) CELL FUNCTIONWilliam Carson; Fiscal Year: 1999....
- INTESTINAL CYTOKINES IN CRYPTOSPORIDIOSISA White; Fiscal Year: 2005..By contrast, naive, symptomatic individuals initially expressed Interleukin 15 (IL-15), which was associated with control of oocyst excretion...
- ONTOGENY OF MEASLES IMMUNITY IN INFANTSAnn Arvin; Fiscal Year: 2006..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
- ONTOGENY OF MEASLES IMMUNITY IN INFANTSHayley Gans; Fiscal Year: 2009..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
- Dendritic cell targeted hepatitis c virus immunotherapyTyler Curiel; Fiscal Year: 2003..that express and secrete DC-targeted NS3. A needle-less and non-toxic immunotherapy would provide a treatment for hepatitis C patients who currently have none. ..
- Urine mRNA Profiling for Renal Allograft SurveillanceManikkam Suthanthiran; Fiscal Year: 2006..abstract_text> ..
- An Anti-tumor Therapy Utilizing EP to Deliver IL-15 into B16.F10 MelanomaBERNADETTE MARRERO; Fiscal Year: 2010..b>Interleukin 15 (IL-15) is a cytokine that activates natural killer (NK) cells and stimulates CD8+ T cells to exhibit long-..
- Role of T Cell Immunity in Primate AIDSAftab Ansari; Fiscal Year: 2006....
- Enhancing HIV-specific CD8+ T cells with IL-15.PETER KATSIKIS; Fiscal Year: 2005..b>Interleukin 15 (IL-15) is a pluripotent cytokine that expands in vivo memory CD8+ T cells, enhances their survival, and ..
- Active Immune Therapy and HAART for HIV-1 InfectionDavid Weiner; Fiscal Year: 2009..Another parallel trial, conducted by the HVTN will test these products in HIV uninfected individuals. ..
- IL-15, Body Compositition and Insulin Sensivity in AgingLeBris S Quinn; Fiscal Year: 2010..abstract_text> ..
- Transport of TNFalpha across the BBBWeihong Pan; Fiscal Year: 2008..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
- Transport of neurotrophic cytokines after spinal cord injuryWeihong Pan; Fiscal Year: 2007..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
- Natural Killer Cell Mediated Control of Vaccinia VirusAnthony French; Fiscal Year: 2007..The proposed work will occur under the mentorship of Dr. Wayne Yokoyama a recognized pioneer in the NK cell field who has successfully trained numerous graduate students and postdoctoral fellows. [unreadable] [unreadable]..
- THYMUS AND CENTRAL TOLERANCEJonathan Sprent; Fiscal Year: 2003..Resolving these questions will shed light on the basic mechanisms involved in self/non-self discrimination, the induction of autoimmune disease and the immune responses to neoplastic cells. ..
- T CELL TURNOVER AND THE ROLE OF CYTOKINESJonathan Sprent; Fiscal Year: 2004....
- BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTESEllen Ebert; Fiscal Year: 2002..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
- T Cell Expansion and Colitis in Immunodeficient MiceCharles Surh; Fiscal Year: 2009..Third, cellular mechanisms involved in regulating potentially pathogenic CD4 cells will be better defined. Results from these investigations may be useful in designing better approaches for preventing or treating IBDs in humans. ..
- REGULATION OF T CELL HOMEOSTASIS AND SURVIVALCharles Surh; Fiscal Year: 2009..The findings from these studies are likely to have important implications for the design of vaccines and therapies for treatment of immunodeficiencies and cancer. ..
- Homeostasis of Mature T Cells in the AgedCharles Surh; Fiscal Year: 2005..Third, the possibility of restoring the naive T cell pool in old mice through manipulation of the homeostatic factors will be tested. ..
- Regulation of normal human IEL by NKG2D and IL-15Bana Jabri; Fiscal Year: 2010....
- Correlative Studies for Phase II Trial of IL12 and IFNaWilliam Carson; Fiscal Year: 2002..This series of experiments will permit us to evaluate the patient response to cytokine therapy at the cellular and molecular levels and identify key determinants of cytokine responsiveness. ..
- CD4 T Cell Activation in SIV+Disease Resistant MangabeysAftab Ansari; Fiscal Year: 2004..abstract_text> ..
- LETHAL OROESOPHAGEAL CANDIDIASIS: IMMUNOTHERAPYEdward Balish; Fiscal Year: 2004..Restoration and enhancement of immune function may be critical for the effectiveness of anti-Candida vaccines that are now under development. ..
- ELECTROCHEMOTHERAPY FOR TREATING SOFT TISSUE SARCOMASRichard Heller; Fiscal Year: 2002..An important consideration in the treatment of soft tissue sarcoma is to be able to perform limb sparing procedures which maintain functionality. ECT combined with surgery could fill this role. ..
- HIV INFECTION/COCAINE EFFECT ON CARDIOVASCULAR PATHOLOGYAftab Ansari; Fiscal Year: 2003..We reason that such studies may provide unique insights on the relationship between the effects of cocaine and HIV infection in the pathogenesis of cardiovascular disease. ..
- DETECTION OF IMMUNOGENIC OVARIAN CANCER ANTIGENSMarcus Butler; Fiscal Year: 2005..Butler will receive from his mentor, as well as his collaborators, will enable Dr. Butler to mature into a leading clinician-scientist interested in translating breakthroughs in immunotherapy to the care of patients. ..
- THERAPEUTIC RESPONSE IN LGL LEUKEMIAThomas Loughran; Fiscal Year: 2005..Treatment effects on expression of STAT-regulated genes will be examined using microarray analyses. Results of these studies should identify important molecular targets for drug development in hematologic malignancies. ..
- MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITYBali Pulendran; Fiscal Year: 2007..unreadable] [unreadable]..
- Amphiregulin in Psoriatic Epidermal HyperplasiaJAMES TILFORD ELDER; Fiscal Year: 2010..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
- POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLSBali Pulendran; Fiscal Year: 2010..The focus of the present proposal is to understand how this signaling pathway in DCs, regulates inflammation, immunological tolerance and vaccine induced immunity. ..
- In vivo significance of T-reg cells during FIV infectionGregg Dean; Fiscal Year: 2006..Results from these studies will provide a clinical understanding of Treg function in HIV infection and will guide future approaches to modulate Treg function. ..
- Cytokine Polymorphisms and Hodgkin Lymphoma RiskWendy Cozen; Fiscal Year: 2006..This study is important since it may will lead to identification of causal genetic factors which may offer alternative therapeutic strategies or prevention. ..
- Caloric restrictions and immune senescenceJanko Nikolich Zugich; Fiscal Year: 2006..This will not only test the validity of observations in rodents, but also put limits on current hypotheses and allow for the rational setting of new ones. ..
- Therapy of Melanoma with Bortezomib and Interferon-alphaWilliam Carson; Fiscal Year: 2007..These studies will help to define the specific apoptotic and immunostimulatory pathways that are being modulated by the combination of bortezomib and IFN-a2b. [unreadable] [unreadable]..
- Differential cytokine responses in Hep C patients.Milton Taylor; Fiscal Year: 2005..We will attempt to establish an in vitro system that mimics in vivo events. This combination of experiments should identify factors that are important in the differential responses to treatment and viral resistance. ..
- MOLECULAR MECHANISMS OF CD4+ T CELL DYSFUNCTION IN SIVAftab Ansari; Fiscal Year: 2009..abstract_text> ..
- INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASISAVERIL I MA; Fiscal Year: 2010..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..