interleukin 10

Summary

Summary: Factor that is a coregulator of mast cell growth. It is produced by T-cells and B-cells and shows extensive homology with the Epstein-Barr virus BCRFI gene.

Top Publications

  1. ncbi Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    Christian Karagiannidis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 114:1425-33. 2004
  2. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
  3. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
  4. pmc Interleukin-10: new perspectives on an old cytokine
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Immunol Rev 226:205-18. 2008
  5. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
  6. ncbi Interleukin-10 therapy--review of a new approach
    K Asadullah
    Head of Corporate Research Business Area Dermatology, Schering AG, D 13342 Berlin, Germany
    Pharmacol Rev 55:241-69. 2003
  7. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
  8. ncbi Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 8:1363-71. 2007
  9. ncbi Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    C S Hsieh
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 260:547-9. 1993
  10. ncbi Interleukin-10 and related cytokines and receptors
    Sidney Pestka
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Annu Rev Immunol 22:929-79. 2004

Detail Information

Publications292 found, 100 shown here

  1. ncbi Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    Christian Karagiannidis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 114:1425-33. 2004
    ..The loss of peripheral tolerance against allergens causes diseases that can be therapeutically controlled with glucocorticoids...
  2. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  3. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  4. pmc Interleukin-10: new perspectives on an old cytokine
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Immunol Rev 226:205-18. 2008
    ..In this review, we summarize what is known about the regulation of IL-10 gene expression by various immune cells. We speculate on the promise that this cytokine holds to influence immune responses and mitigate immune pathologies...
  5. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy...
  6. ncbi Interleukin-10 therapy--review of a new approach
    K Asadullah
    Head of Corporate Research Business Area Dermatology, Schering AG, D 13342 Berlin, Germany
    Pharmacol Rev 55:241-69. 2003
    ..The results are heterogeneous. They give new insight into the immunobiology of IL-10 and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target...
  7. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    ..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
  8. ncbi Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 8:1363-71. 2007
    b>Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective and pathological T cell responses...
  9. ncbi Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    C S Hsieh
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 260:547-9. 1993
    ..Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH phenotype...
  10. ncbi Interleukin-10 and related cytokines and receptors
    Sidney Pestka
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Annu Rev Immunol 22:929-79. 2004
    ..Further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a variety of diseases...
  11. ncbi The many faces of macrophage activation
    David M Mosser
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 73:209-12. 2003
  12. ncbi The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria
    N P Day
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Infect Dis 180:1288-97. 1999
    ..Both the overall magnitude of the cytokine responses and the eventual imbalance between the pro- and antiinflammatory responses are important determinants of mortality...
  13. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  14. ncbi A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    Amit Awasthi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 8:1380-9. 2007
    ..that lack Foxp3 expression also regulate T cell function, mainly by producing the immunosuppressive cytokine interleukin 10 (IL-10)...
  15. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
    ..Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders...
  16. pmc Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis
    Susanne Nylen
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:805-17. 2007
    ..The elevated levels of IL-10 in VL plasma significantly enhanced the growth of L. donovani amastigotes in human macrophages. The data implicate IL-10-producing CD25(-)Foxp3(-) T cells in the pathogenesis of human VL...
  17. ncbi Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils
    Xiaoming Zhang
    Institut Pasteur, Unité Régulation Immunitaire et Vaccinologie, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Immunity 31:761-71. 2009
    ..During a chronic infection, neutrophil depletion promoted inflammation and decreased the mycobacterial burden. Therefore, neutrophils can have a previously unsuspected regulatory role during acute and chronic microbial infections...
  18. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen...
  19. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005
    ..We conclude that OX40L on TSLP-activated DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10-producing regulatory Th cell responses into TNF-alpha-producing inflammatory Th cell responses...
  20. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
    ....
  21. pmc Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells
    Simona Stager
    Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, York, UK
    Eur J Immunol 36:1764-71. 2006
    ..Breadth of cytokine production is thus an important factor when considering strategies for DC-based interventions...
  22. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
    ..Moreover, we demonstrate that DC-SIGN has a broader pathogen recognition profile than previously shown, suggesting that DC-SIGN may represent a molecular target for clinical intervention in infections other than HIV-1...
  23. ncbi Interleukin-10 and the pathogenesis of human visceral leishmaniasis
    Susanne Nylen
    Laboratory of Parasitic Diseases, Bldg 4 RmB1 12, National Institute of Allergy and Infectious Diseases, 4 Center Drive MSC0425, Bethesda, MD 20892 0425, USA
    Trends Immunol 28:378-84. 2007
    ..Here, we review the studies with relevance to immune responses in human VL and highlight the central role that IL-10 might have in the pathogenesis of VL and as a target for immune-based therapy...
  24. ncbi Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    O Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 94305-5208, USA
    Nat Immunol 2:725-31. 2001
    ..report here that pulmonary dendritic cells (DCs) from mice exposed to respiratory antigen transiently produced interleukin 10 (IL-10)...
  25. ncbi The role of IL-10 in promoting disease progression in leishmaniasis
    M M Kane
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 166:1141-7. 2001
    ..This IgG allows amastigotes to exploit the antiinflammatory effects of Fc gamma R ligation to induce the production of IL-10, which renders macrophages refractory to the activating effects of IFN-gamma...
  26. pmc Role of cytokines in inflammatory bowel disease
    Fausto Sanchez-Munoz
    World J Gastroenterol 14:4280-8. 2008
    ..Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cytokine therapies have been developed and tested for the treatment of IBD patients...
  27. ncbi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  28. ncbi Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    Megan K Levings
    San Rafaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 105:1162-9. 2005
    ..Thus, iDCs can drive the differentiation of Tr1 cells and can be used to generate large numbers of alloantigen-specific Tr1 cells for clinical use as a cellular therapy to restore peripheral tolerance...
  29. ncbi Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel 24105, Germany
    Nat Genet 40:1319-23. 2008
    ..Among the four consistently replicated markers, SNP rs3024505 immediately flanking the IL10 (interleukin 10) gene on chromosome 1q32.1 showed the most significant association in the combined verification samples (P = 1...
  30. pmc Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy
    Henry W Murray
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Infect Immun 70:6284-93. 2002
    ..IL-10's deactivating effects regulate outcome in experimental visceral leishmaniasis, and IL-10R blockade represents a potential immuno- and/or immunochemotherapeutic approach in this infection...
  31. ncbi Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria
    J A Kurtzhals
    Immunology Unit, Noguchi Memorial Institute for Medical Research, Legon, Ghana
    Lancet 351:1768-72. 1998
    ..Conversely, interleukin 10 (IL-10), which mediates feed-back regulation of TNF, stimulates bone-marrow function in vitro and counteracts ..
  32. ncbi Interleukin-10 and the immune response against cancer: a counterpoint
    Simone Mocellin
    Department of Oncological and Surgical Sciences, University of Padova, Italy
    J Leukoc Biol 78:1043-51. 2005
    ....
  33. pmc Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
    J Exp Med 193:1295-302. 2001
    ....
  34. pmc Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 195:221-31. 2002
    ..The induction of Tr1 cells after interaction of a pathogen-derived molecule with cells of the innate immune system represents a novel strategy exploited by an infectious pathogen to subvert protective immune responses in vivo...
  35. ncbi An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Roli Khattri
    Celltech R and D Inc, 1631 220th Street SE, Bothell, Washington 98021, USA
    Nat Immunol 4:337-42. 2003
    ..The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage...
  36. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  37. ncbi Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    Maria Grazia Roncarolo
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
    Immunol Rev 212:28-50. 2006
    ....
  38. ncbi Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 172:3712-8. 2004
    ..In conclusion, C. albicans induces immunosuppression through TLR2-derived signals that mediate increased IL-10 production and survival of Treg cells. This represents a novel mechanism in the pathogenesis of fungal infections...
  39. ncbi Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Immunol 8:1372-9. 2007
    ..Our data show that IL-27-induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27...
  40. pmc Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    Krisztian Nemeth
    National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
    Nat Med 15:42-9. 2009
    ....
  41. ncbi IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3
    M Tone
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 165:286-91. 2000
    ..The requirement for Sp1 and Sp3 in transcription of IL-10 was confirmed using Drosophila SL2 cells, which lack endogenous Sp factors. These results suggest that the transcription of IL-10 is positively regulated by both Sp1 and Sp3...
  42. pmc Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    Tomoki Ito
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:870-80. 2008
    ....
  43. ncbi CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes
    Myoung Ho Jang
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Immunol 176:803-10. 2006
    ..Collectively, these results strongly suggest that LP-DCs with unique immunomodulatory activities migrate to MLNs in a CCR7-dependent manner to engage in the presentation of IEC-associated Ags acquired in the LP...
  44. pmc An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    C Asseman
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Exp Med 190:995-1004. 1999
    ..These findings provide the first clear evidence that IL-10 plays a nonredundant role in the functioning of regulatory T cells that control inflammatory responses towards intestinal antigens...
  45. ncbi Regulatory T cells and mechanisms of immune system control
    Anne O'Garra
    Division of Immunoregulation, The National Institute for Medical Research, London NW7 1AA, UK
    Nat Med 10:801-5. 2004
    ..We discuss here the varied mechanisms used by T(reg) cells to suppress the immune system...
  46. ncbi A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
    H Groux
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:1723-9. 1999
    ..These results demonstrate, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo...
  47. ncbi TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
    ..Our findings suggest that full acquisition of pathogenic function by effector T(H)-17 cells is mediated by IL-23 rather than by TGF-beta and IL-6...
  48. ncbi Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis
    Valerie Guyot-Revol
    Tuberculosis Immunology Group, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 7, Oxford OX3 9DU, UK
    Am J Respir Crit Care Med 173:803-10. 2006
    ..CD4+CD25(high) regulatory T cells mediate suppressed cellular immunity in several chronic infections but have not been described in TB...
  49. ncbi A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    J Neuroimmunol 165:63-74. 2005
    ..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE...
  50. ncbi Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice
    K L Madsen
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 116:1107-14. 1999
    ..The aim of this study was to determine the role of colonic aerobic luminal bacteria and Lactobacillus species in the development of colitis in interleukin (IL)-10 gene-deficient mice...
  51. ncbi Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
    Craig L Maynard
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 8:931-41. 2007
    CD4(+) regulatory T cells (T(reg) cells) that produce interleukin 10 (IL-10) are important contributors to immune homeostasis...
  52. ncbi The interleukin-10 family of cytokines
    Helmut Fickenscher
    Hygiene Institut, Abteilung Virologie, Ruprecht Karls Universitat Heidelberg, Germany
    Trends Immunol 23:89-96. 2002
    ....
  53. pmc A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice
    C Li
    Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
    Infect Immun 67:4435-42. 1999
    ....
  54. ncbi An investigation of polymorphism in the interleukin-10 gene promoter
    D M Turner
    Tissue Typing Laboratory, St Mary s Hospital, Manchester, UK
    Eur J Immunogenet 24:1-8. 1997
    ..We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro...
  55. ncbi Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
    Claudia Di Giacinto
    Immune Mediated Diseases Section, Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 174:3237-46. 2005
    ..These studies show that probiotic (VSL#3) administration during a remission period ameliorates the severity of recurrent colitis by inducing an immunoregulatory response involving TGF-beta-bearing regulatory cells...
  56. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  57. ncbi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations, with the potential for preventive therapies and cure for allergic diseases...
  58. ncbi Interleukin-10 in viral diseases and cancer: exiting the labyrinth?
    Alain P Vicari
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunol Rev 202:223-36. 2004
    ..In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens...
  59. pmc Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 192:1213-22. 2000
    ..These data show that immature and mature DCs induce different types of T cell responses: inflammatory Th1 cells are induced by mature DCs, and IL-10-producing T cell regulatory 1-like cells by immature DCs...
  60. pmc Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    Michael Martin
    Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nat Immunol 6:777-84. 2005
    ..or peripheral blood mononuclear cells with TLR2, TLR4, TLR5 or TLR9 agonists induced substantial increases in interleukin 10 production while suppressing the release of proinflammatory cytokines after GSK3 inhibition...
  61. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
    ..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals...
  62. pmc T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    N J Davidson
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    J Exp Med 184:241-51. 1996
    Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD...
  63. pmc IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways
    A M O'Farrell
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    EMBO J 17:1006-18. 1998
    ..Thus signals mediating both anti-proliferative and macrophage de-activation responses to IL-10 require the two membrane-distal tyrosines of IL-10R, but Stat3 appears to function only in the anti-proliferative response...
  64. ncbi IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
    E Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:3299-306. 1998
    ..Taken together, our data suggest that IL-10 plays a more critical role in the regulation of EAE by regulating autopathogenic Th1 responses...
  65. pmc Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50
    F Driessler
    Research Business Area Dermatology, Research Laboratories of Schering AG, Berlin, Germany
    Clin Exp Immunol 135:64-73. 2004
    ..Our findings suggest that the selective induction of nuclear translocation and DNA-binding of the repressive p50/p50 homodimer is an important anti-inflammatory mechanism utilized by IL-10 to repress inflammatory gene transcription...
  66. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
  67. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ....
  68. ncbi Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus
    Hye Young Chun
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Woncheon dong, San5, Youngtong Gu, Suwon 443 721, South Korea
    J Clin Immunol 27:461-6. 2007
    ..No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE...
  69. ncbi Ethnic-specific genetic associations with pulmonary tuberculosis
    Julio C Delgado
    Center for Blood Research and Departments of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 186:1463-8. 2002
    ....
  70. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient ..
  71. pmc A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
    Suzanne A Miles
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Exp Med 201:747-54. 2005
    ..We conclude that IgG can cause a novel form of immune enhancement due to its ability to induce IL-10 production from macrophages...
  72. pmc Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma
    H Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Austria
    Gut 50:191-5. 2002
    b>Interleukin 10 (IL-10) exerts anti-inflammatory actions by counteracting many biological effects of interferon gamma (IFN-gamma).
  73. ncbi Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice
    David Sacks
    Laboratory of Parasitic Diseases, NIAID, Bethesda, MD, USA
    Immunol Rev 201:225-38. 2004
    ....
  74. pmc Interleukin-10 production by effector T cells: Th1 cells show self control
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 204:239-43. 2007
    ..But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens...
  75. ncbi Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system
    Mandy J McGeachy
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 175:3025-32. 2005
    ..These are the first data demonstrating the direct involvement of CD4+CD25+ regulatory T cells in the natural resolution of autoimmune disease within the target organ...
  76. ncbi CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 63:6042-50. 2003
    ..Regulatory lymphocytes and cytokines may have implications for novel therapies for colon cancer in humans...
  77. pmc Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 196:1253-62. 2002
    ..Together, these findings demonstrate a new pathway involving the induction of host LXs for the in vivo regulation of proinflammatory responses during microbial infection...
  78. pmc Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
    S V Kotenko
    Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Proc Natl Acad Sci U S A 97:1695-700. 2000
    ..We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system...
  79. ncbi IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:6406-16. 2000
    ....
  80. pmc Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells
    Yongpeng Gu
    Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Immunol 38:1807-13. 2008
    ..These data demonstrate that Th17 cytokines and RORgammat are also expressed in macrophages and that IL-10 negatively regulates the expression of Th17 cytokines and RORgammat by both macrophages and T cells...
  81. ncbi Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells
    K Steinbrink
    Department of Dermatology, University of Mainz, Mainz, Germany and the Department of Dermatology, University of Erlangen, Erlangen, Germany
    Blood 93:1634-42. 1999
    ....
  82. ncbi The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major
    Nancy Noben-Trauth
    Department of Immunology, George Washington University Medical Center, Washington, DC 20037, USA
    J Immunol 170:5152-8. 2003
    ..These studies suggest that regardless of parasite substrain, IL-10 is as important as IL-4/IL-13 in promoting susceptibility to L. major and even more so for those substrains that are relatively resistant to IFN-gamma mediated killing...
  83. pmc The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
    Alejandro Villagra
    Division of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Nat Immunol 10:92-100. 2009
    ..family with no prior defined physiological function, negatively regulated expression of the gene encoding interleukin 10 (IL-10) in APCs...
  84. ncbi Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    Masahito Kamanaka
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:941-52. 2006
    ..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
  85. ncbi Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  86. pmc Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis
    J O Lindsay
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, UK
    Gut 52:363-9. 2003
    b>Interleukin 10 knockout (IL-10-/-) mice spontaneously develop a Th1 T cell mediated colitis with many similarities to Crohn's disease. Daily injections of IL-10 are unable to induce remission in mice with established disease...
  87. ncbi Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency
    Klaus Warnatz
    Division of Rheumatology and Clinical Immunology, University Hospital, Freiburg, Germany
    Blood 107:3045-52. 2006
    ..Human ICOS deficiency is indistinguishable from CVID and thus serves as a monogenic model for this complex syndrome...
  88. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601 0275, USA
    Lab Invest 86:1136-48. 2006
    ..These results also reinforce the notion that IL-10 exerts multiple functions and commend caution in equating high levels of IL-10 and increased pathogenesis in systemic autoimmunity...
  89. ncbi Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 10:39-49. 1999
    ..The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10...
  90. ncbi IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses
    John J Lazarus
    Department of Medical Microbiology and Immunology, Medical University of Ohio, Toledo, OH 43614, USA
    J Immunol 177:7076-85. 2006
    ..These findings confirm that B. burgdorferi clearance by innate immune responses is more efficient in the absence of IL-10, and these activities are not directly related to increased levels of B. burgdorferi-specific Ab...
  91. ncbi The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    R P Donnelly
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 19:563-73. 1999
    ..Thus, the ability of IL-10 to inhibit gene expression in monocytes is associated with its ability to rapidly induce synthesis of SOCS-3...
  92. ncbi Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle
    Dawen Liu
    Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, 70803, USA
    Eur J Oral Sci 114:42-9. 2006
    ..In these knockdowns, RANKL expression was increased and OPG expression was decreased. All of these results suggest that IL-10 inhibits bone resorption by up-regulating OPG expression while down-regulating expression of RANKL and CSF-1...
  93. pmc Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice
    Gillian L Beamer
    Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 181:5545-50. 2008
    ..Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans...
  94. pmc IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
    Mark A Brockman
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 114:346-56. 2009
    ..These data indicate that multiple cell types contribute to IL-10-mediated immune suppression in the presence of uncontrolled HIV viremia...
  95. pmc Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 204:1217-25. 2007
    ..Collectively, the results indicate that modulating effector T cell differentiation can counteract pathogen exploitation of the mucosa, thus limiting persistent virus replication and transmission...
  96. ncbi Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level
    Fina A S Kurreeman
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    Hum Mol Genet 13:1755-62. 2004
    ..These findings show that interindividual differences in IL10 protein levels can be explained at the transcriptional level...
  97. ncbi IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation
    William H Peranteau
    Department of Surgery, The Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Invest Dermatol 128:1852-60. 2008
    ..We conclude that lentivirus-mediated overexpression of IL-10 decreases the inflammatory response to injury, creating an environment conducive for regenerative adult wound healing...
  98. ncbi Gene transfer of interleukin 10 to the murine cornea using electroporation
    Rui Zhou
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Exp Biol Med (Maywood) 232:362-9. 2007
    ..We have used electroporation to deliver plasmids expressing interleukin 10 (IL-10) to the corneas of mice and evaluated the duration of expression following gene transfer...
  99. pmc Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells
    Megan K Levings
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Exp Med 196:1335-46. 2002
    ..Together these data indicate that naturally occurring human CD25(+)CD4(+) T cells are distinct from IL-10-producing Tr1 cells...
  100. ncbi Regulatory activity of autocrine IL-10 on dendritic cell functions
    S Corinti
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 166:4312-8. 2001
    ..Moreover, IL-10R expression appears to be regulated by both transcriptional and posttranscriptional mechanisms. Endogenous IL-10 and IL-10R can be relevant targets for the manipulation of DC functions...
  101. pmc Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?
    W M Gonsalkorale
    Department of Medicine, University Hospital of South Manchester, Nell Lane, Manchester M20 2LR, UK
    Gut 52:91-3. 2003
    ....

Research Grants72

  1. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  2. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  3. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ....
  4. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..Determining the role of IL-10 in mediating fatal viral encephalomyelitis pathology will increase our understanding of the mechanisms responsible for severe and fatal infections and provide a basis for therapeutic development. ..
  5. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ..Commensal enteric bacteria antigen-specific effector T cells that cause chronic colitis in interleukin 10 deficient (IL-10-/-) mice...
  6. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2013
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  7. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
  8. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..coli, the genetically susceptible individual's ability to process these organisms, and subsequent metabolic pathways involved in disease pathogenesis. ..
  9. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..Positive predictive studies in human ALI/ARDS would have a high impact on our understanding of the resolution of sepsis and MODS. ..
  10. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ....
  11. Interleukin-10 and Regulation of Skeletal Muscle Insulin Action
    Jason K Kim; Fiscal Year: 2012
    ..Our findings will provide important insights into the role of obesity and inflammation in insulin resistance and further identify novel therapeutic targets in the treatment of type 2 diabetes. ..
  12. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors. ..
  13. Immune Regulation of Virus Clearance and Tissue Injury at Sites of Infection
    Thomas J Braciale; Fiscal Year: 2013
    ..To determine the impact of viral infection on the production of Te-derived IL- 10. The proposed studies are designed to complement ongoing related studies in Projects 2, 3 and 4. ..
  14. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2013
    ..Our long-term goal is to use p40 as a novel therapeutic agent for human intestinal inflammatory disorders. ..
  15. MECHANISMS OF THE INDUCTION OF ORAL TOLERANCE
    Howard L Weiner; Fiscal Year: 2013
    ..We will investigate mechanisms to induce regulatory T cells by oral tolerance, which takes advantage of natural protective mechanisms that exist in the gut. ..
  16. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..The studies in this project will provide insights into potential novel therapies to prevent this condition and, hence, prolong survival of kidney transplants. ..
  17. Prevention of diabetes by pDNA encoded with IL-10
    Jagdish Singh; Fiscal Year: 2010
    ..The proposed study will contribute towards the development of a high efficiency and low toxicity non-viral gene delivery vehicle in order to deliver plasmid encoding IL-10 gene for prevention of type 1 diabetes. ..
  18. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..Effective protocols for inactivating prions will protect the general public as well as laboratory scientists who are investigating prions. Rarely does a research study have such immediate and important implications. ..
  19. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  20. A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathy
    Daniela Salvemini; Fiscal Year: 2013
    ..Given the breadth of disorders impacted by A3AR agonists understanding their mechanism-based effects has far-reaching basic science &clinical implications. ..
  21. Suppressors of cytokine signaling (SOCS) in HAART-treated HIV infection
    Maria C Villacres; Fiscal Year: 2010
    ..As the number of HIV-infected women increase, especially among African-American and Latino minorities, it is highly relevant to understand the reasons for disease progression despite efficient anti-viral treatment. ..
  22. Manipulating Macrophage Phenotype in Laryngeal Nerve Repair
    Jonathan Cheetham; Fiscal Year: 2013
    ..This team will support me in this proposal and through my transition to independence. ..
  23. Role of Bacteria in Colitis-associated Colon Cancer
    Christian Jobin; Fiscal Year: 2013
    ..In addition, the basic knowledge gained from metagenomic studies is expected to move the general field of CRC research forward. ..
  24. Virulence in Enteroaggregative Escherichia coli
    James P Nataro; Fiscal Year: 2013
    ..In this project, we will further characterize the mechanisms of EAEC- induced diarrhea with an eye toward development of effective preventive measures. ..
  25. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. ..
  26. Attenuated RhCMV Delta 10 SIV Oral Vaccine Vectors Encoding TLR5 Ligand Sequences
    ELLEN ELIZABETH SPARGER; Fiscal Year: 2013
    ..Importantly, these studies will examine and develop a novel vaccine approach that is not previously tested in the SIVmac vaccine model, and carries the potential to significantly impact HIV vaccine design. ..
  27. HIF-1alpha Mediated Wound Healing in Periapical Lesion
    Hajime Sasaki; Fiscal Year: 2013
    ..These outcomes are targeted to novel treatment strategies to improve the healing process in dentoalveolar infections that will have potential application in other chronic fibrotic and granulomatous diseases. ..
  28. Immune and Gilia Regulation of Pain &Analgesic Actions
    Linda Watkins; Fiscal Year: 2012
    ..abstract_text> ..
  29. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  30. Spinal Neuroimmune Mechanisms Underlying IL-10 Gene Therapy for Pain Control
    Erin D Milligan; Fiscal Year: 2013
    ....
  31. Mechanisms by which IL-10 limits Toll-like Receptor 9 mediated Macrophage Activat
    Scott Canna; Fiscal Year: 2012
    ..Mice repeatedly stimulated through TLR9 who are unable to signal through the interleukin 10 (IL-10) receptor develop much more severe disease, underscoring the critical role of IL-10 as a negative ..
  32. New Model Leading to Preterm Delivery: Role of Exposure to Environmental Toxins
    Nazeeh N Hanna; Fiscal Year: 2010
    ..These findings will be useful in studies aimed at identifying more effective prevention and treatment strategies for preterm labor. ..
  33. Anti-Inflammatory mechanisms of soybean-derived Bowman-Birk protease inhibitor
    Abdolmohamad Rostami; Fiscal Year: 2012
    ..In our previous study we discovered that BBI increases production of interleukin 10 (IL-10)...
  34. Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
    Xiaojing Ma; Fiscal Year: 2011
    ..abstract_text> ..
  35. B-Cell Tolerance Mechanisms in Human SLE
    JENNIFER HOWITT ANOLIK; Fiscal Year: 2013
    ..The knowledge gained from the present studies will help us understand the multiple functions of B cells in autoimmunity and develop better strategies for the treatment of lupus and other autoimmune diseases. ..
  36. Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric Cortico
    SIMON PATRICK HOGAN; Fiscal Year: 2013
    ....
  37. Small Molecules Targeting Allele Specific MHC Class II Presentation
    Aaron W Michels; Fiscal Year: 2013
    ....
  38. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2011
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
  39. TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
    Daniel H Teitelbaum; Fiscal Year: 2013
    ....
  40. The Role of IL-10 in Regulation of Allergic Inflammation
    BILL AMEREDES; Fiscal Year: 2009
    ..4/98) (Form Page 3) Page __3._ CC Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  41. Modulating and Monitoring the Foreign Body Response to Implants
    Julie A Stenken; Fiscal Year: 2013
    ..The combination of these approaches will provide rapid translation of in vitro studies to animal models with efficacy verification. ..
  42. Oxidized lipids and UV immunosuppression
    Jeffrey B Travers; Fiscal Year: 2013
    ..Moreover, UVB radiation treatments are used clinically to treat inflammatory skin disorders, in great part to its immunosuppressive effects. These studies should result in an enhanced understanding of this important process. ..
  43. Spinal adenosine modulator: enduring anti-inflammatory action in neuropathic pain
    Linda Watkins; Fiscal Year: 2010
    ..This project is aimed at providing the "proof-of-concept" for using A2A agonists as a new therapeutic approach for chronic pain. ..
  44. LIAI Epitope Validation Center: Characterization of Allergen specific T Cells
    ALESSANDRO D SETTE; Fiscal Year: 2013
    ..abstract_text> ..
  45. Helminthic Protection from IBD
    JOEL VINCENT WEINSTOCK; Fiscal Year: 2013
    ..Results from this study could help improve the treatment of patients with IBD and other immunological disease. ..
  46. Role of aryl hydrocarbon receptor in IL-10 producing Tr1 regulatory cells
    Francisco J Quintana; Fiscal Year: 2013
    ..We will investigate how a protein called Aryl Hydrocarbon Receptor controls the immune system and how affecting it ameliorates an animal model of multiple sclerosis. ..
  47. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..Our preliminary data suggest that transgene-mediated p55 soluble tumor necrosis factor receptor (p55sTNFR) or interleukin 10 reduces pain-related behavior and downregulates the increases in the spinal TNF1 and phosphorylation of p38 (p-..
  48. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
    ....
  49. Mechanisms of Vascular Dysfunction in Diet-Induced Obesity
    Sean P Didion; Fiscal Year: 2013
    ..Results from these studies should provide new insight into mechanisms related to oxidative stress and vascular dysfunction in response to a diet high in fat and are aimed at improving public health. ..
  50. Diagnosis and Pathobiology of Emerging Enterohepatic Helicobacter spp. in Mice
    James G Fox; Fiscal Year: 2011
    ..The proposal addresses molecular targets for diagnosis and characterization of EHS and will take advantage of sequenced EHS that colonize mice to probe virulence determinants shared among these EHS isolated from both mice and humans. ..
  51. Molecular Regulation of MS Susceptibility Genes
    Casey T Weaver; Fiscal Year: 2013
    ..Using this model, we will be able to define the function of Gfi1-binding CREs in the human IL10 locus by examining the effects of mutation of these elements on IL10 gene remodeling, expression and protection in the EAE model. ..
  52. The influence of DNA repair on inflammation associated carcinogenesis
    Leona D Samson; Fiscal Year: 2013
    ..Understanding how DNA repair contributes to carcinogenesis will provide insights into the mechanism by which chronic inflammation increases the chance of cancer as well as identify possible approaches to decrease cancer risk. ..
  53. Diagnosis and Pathobiology of Emerging Enterohepatic Helicobacter spp. in Mice
    James G Fox; Fiscal Year: 2013
    ..To accomplish these aims we have assembled a team of scientists who have successfully collaborated together for the last decade to study the etiopathogenesis of H. hepaticus gastrointestinal disease in mice. ..
  54. A Comparative Genomics and Transgenic Approach to Regulation of IL-10 Expression.
    Jay H Bream; Fiscal Year: 2013
    ..Together, these studies will clarify how cell- and allele-specific regulation of hIL-10 production contributes to human inflammatory diseases. ..
  55. Development of Biomaterials that Release Therapeutic Agents to Modulate Inflammat
    Ryan J Gilbert; Fiscal Year: 2010
    ..The research described in this proposal will determine if hydrogels loaded with glutathione or interleukin-10 are more effective at reducing secondary injury than injection of these agents in a rat spinal cord injury model. ..
  56. Helminthic Protection from IBD
    Joel Weinstock; Fiscal Year: 2009
    ..This investigation may provide fresh insight into the pathogenesis of IBD and lead to better treatment. ..
  57. Investigating the Role of IL35 in Anti-Tumor Immunity
    Meghan E Turnis; Fiscal Year: 2013
    ..Research on these Aims should yield exciting knowledge that will advance the field and hopefully prove to be therapeutically beneficial. ..
  58. In vivo function and tolerance to Factor VIII variants
    BRENDAN HL LEE; Fiscal Year: 2011
    ..abstract_text> ..
  59. Lung Fluid Balance and Mesenchymal Stem Cells
    Michael A Matthay; Fiscal Year: 2012
    ....
  60. XT-101: A Potent IL-10 Based Therapy for Treating Multiple Sclerosis.
    Raymond A Chavez; Fiscal Year: 2013
    ..Because the method of action of XT-101 is markedly different from all existing or imminent MS treatments, it has the potential to be an extremely useful addition and complement to current medical practice. ..
  61. Targeting the mTOR signaling pathway in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2011
    ..Finally, we will test our hypothesis that MTIs can prevent cancer in ALPS. We anticipate these studies will allow us to revolutionize the treatment of ALPS, improving patient heath and quality of life. ..
  62. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  63. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..The recent finding that large amounts of the cytokine Interleukin 10 (IL-10) are produced in humans and experimental animals with RF borreliosis suggests that IL- 10 plays an ..
  64. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ..interleukin 12 (IL-12), favor the induction of CD8+ CTLs while Th2 cytokines, such as interleukin 4 (IL-4) and interleukin 10 (IL-10) inhibit them...
  65. Mouse Strain dependent innate resistance to intestinal amebiasis
    Eric Houpt; Fiscal Year: 2009
    ....
  66. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2004
    ....
  67. Mechanisms of intestinal failure in post-surgical inflammatory bowel disease
    PAULINE LUND; Fiscal Year: 2009
    ....
  68. GASTRIC PRENEOPLASIA IN H FELIS INFECTED IL10 MICE
    Daniel Berg; Fiscal Year: 2002
    ..the development of preneoplastic gastric epithelium, using a novel animal model, Helicobacter felis-infected interleukin 10-deficient mice (IL10-/-)...
  69. Substance P & the Regulation of Intestinal Inflammation
    Joel Weinstock; Fiscal Year: 2009
    ..Strategies aimed at modulating NK-1 R function in the gut could prove therapeutically beneficial for IBD. ..
  70. REGULATION OF AUTOREACTIVE T CELLS IN IL10 KNOCKOUT MICE
    Peter Ernst; Fiscal Year: 1999
    ..Clarifying the role of these cytokines controlling auto-reactive T cells will define the pathogenesis of colitis and identify therapeutic strategies that can be applied to these intestinal diseases. ..
  71. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    ..This information will provide the framework for rational design of new therapies aimed at modulating immune mechanisms and design of preventative measures aimed at immunization. ..
  72. OLIGOSACCHARIDE TECHNOLOGY TO PREVENT SKIN CANCER
    TODD WALLER; Fiscal Year: 1999
    ..These will be suitable as therapeutic agents for use in a post sun skin care preparation designed to prevent injury by UV radiation to the skin immune system. Such a preparation has potential for prevention of sun-induced skin cancer. ..