interleukin 1

Summary

Summary: A soluble factor produced by monocytes, macrophages, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. IL-1 consists of two distinct forms, IL-1 alpha and IL-1 beta which perform the same functions but are distinct proteins. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation. The factor is distinct from INTERLEUKIN-2.

Top Publications

  1. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
  2. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
  3. pmc Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    Luis A Ortiz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:11002-7. 2007
  4. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
  5. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  6. pmc TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Genes Dev 13:1015-24. 1999
  7. ncbi The balance between IL-1 and IL-1Ra in disease
    William P Arend
    B115 Division of Rheumatology, Health Sciences Centre, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine Growth Factor Rev 13:323-40. 2002
  8. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
  9. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
  10. pmc IL-1 is required for tumor invasiveness and angiogenesis
    Elena Voronov
    Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 100:2645-50. 2003

Detail Information

Publications354 found, 100 shown here

  1. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
    ..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
  2. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
  3. pmc Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    Luis A Ortiz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:11002-7. 2007
    ..Interrogation of the MSC transcriptome identified interleukin 1 receptor antagonist (IL1RN) as a potential mediator of this effect...
  4. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
  5. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  6. pmc TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Genes Dev 13:1015-24. 1999
    ..These findings establish unexpectedly diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling...
  7. ncbi The balance between IL-1 and IL-1Ra in disease
    William P Arend
    B115 Division of Rheumatology, Health Sciences Centre, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine Growth Factor Rev 13:323-40. 2002
    ..Treatment of RA with daily subcutaneous injections of recombinant IL-1Ra protein has been shown to be efficacious. Gene therapy approaches with IL-1Ra are being evaluated for the treatment of RA and other human diseases...
  8. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  9. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
    ..Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation...
  10. pmc IL-1 is required for tumor invasiveness and angiogenesis
    Elena Voronov
    Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 100:2645-50. 2003
    ..Furthermore, the anti-angiogenic effects of IL-1 receptor antagonist, shown here, suggest a possible therapeutic role in cancer, in addition to its current use in rheumatoid arthritis...
  11. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
    ..Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors...
  12. ncbi Toll-like receptors: critical proteins linking innate and acquired immunity
    S Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 2:675-80. 2001
    ..Similar cytoplasmic domains allow TLRs to use the same signaling molecules used by the interleukin 1 receptors (IL-1Rs): these include MyD88, IL-1R--associated protein kinase and tumor necrosis factor receptor--..
  13. ncbi Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context
    Hongmin Chen
    Interleukin Genetics Inc, 135 Beaver Street, Waltham, MA 02452, USA
    Hum Mol Genet 15:519-29. 2006
    ..This finding underlines the importance of understanding the haplotype structure of populations used for genetic studies and may be especially important in the functional analysis of genetic variation across gene regulatory regions...
  14. pmc Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain
    Carina C Ferrari
    Leloir Institute, Universiity of Buenos Aires, Buenos Aires, Argentina
    Am J Pathol 165:1827-37. 2004
    ....
  15. ncbi Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors
    Yakov Krelin
    Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Cancer Res 67:1062-71. 2007
    The role of microenvironment interleukin 1 (IL-1) on 3-methylcholanthrene (3-MCA)-induced carcinogenesis was assessed in IL-1-deficient mice, i.e...
  16. ncbi A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    J C Lee
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406
    Nature 372:739-46. 1994
    ..Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production...
  17. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..The importance of IL-1ra both in normal physiology and under stress is also suggested...
  18. ncbi Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung
    Urpo Lappalainen
    Goteborg University, Department of Pediatrics, The Queen Silvia Children s Hospital, 41685 Goteborg, Sweden
    Am J Respir Cell Mol Biol 32:311-8. 2005
    ..Chronic production of IL-1beta in respiratory epithelial cells of adult mice causes lung inflammation, enlargement of distal airspaces, mucus metaplasia, and airway fibrosis in the adult mouse...
  19. ncbi Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra
    Carina Cintia Ferrari
    Institute Leloir, IIBBA CONICET, FBMC FCEyN Avenue Patricias Argentinas 435 1405, Buenos Aires, Argentina
    Neurobiol Dis 24:183-93. 2006
    ..This model will be helpful to identify possible therapeutic targets related to inflammation-derived neurodegeneration in the SN...
  20. ncbi TRAF6 is a signal transducer for interleukin-1
    Z Cao
    Tularik Inc, South San Francisco, California 94080, USA
    Nature 383:443-6. 1996
    ..These findings indicate that TRAF proteins may function as signal transducers for distinct receptor families and that TRAF6 participates in IL-1 signalling...
  21. pmc IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13249-54. 2001
    ..We conclude that inhibition of ICE represents a novel anti-inflammatory strategy for intestinal inflammation...
  22. ncbi Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes
    L C Tetlow
    University Department of Medicine, Manchester Royal Infirmary, The University of Manchester, UK
    Arthritis Rheum 44:585-94. 2001
    ..These observations support the concept that cytokine-MMP associations reflect a modified chondrocyte phenotype and an intrinsic process of cartilage degradation in OA...
  23. ncbi Role of IL-1alpha and IL-1beta in ischemic brain damage
    H Boutin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 21:5528-34. 2001
    ....
  24. ncbi Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo
    Ahu Birol
    Int J Dermatol 45:992-3. 2006
  25. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells. Together, these data establish that p38 is a member of the mammalian MAP kinase group...
  26. ncbi Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    S W Barger
    Donald W Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Nature 388:878-81. 1997
    ..Because sAPP-beta is deficient in the neuroprotective activity shown by sAPP-alpha, our results indicate that increased amyloidogenic processing could adversely affect the balance of sAPP activities that determine neuronal viability...
  27. ncbi SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
    David Wald
    Cleveland Clinic Foundation, Department of Immunology, Cleveland, Ohio 44195, USA
    Nat Immunol 4:920-7. 2003
    The Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily is important in differentially recognizing pathogen products and eliciting appropriate immune responses...
  28. ncbi Keratins and the keratinocyte activation cycle
    I M Freedberg
    The Ronald O. Perelman Department of Dermatology, New York University Medical Center, New York, USA
    J Invest Dermatol 116:633-40. 2001
    ..Signals from the fibroblasts, in the form of TGF-beta, induce the expression of K5 and K14, revert the keratinocytes to the healthy basal phenotype, and thus complete the activation cycle...
  29. ncbi Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:1793-803. 2002
    ....
  30. ncbi Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population
    Jiyong Liu
    Laboratory of Reproductive Medicine and Applied Toxicology, Nanjing Medical University, and Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 210029, People s Republic of China
    Int J Cancer 118:2554-8. 2006
    ..27-fold (95% CI=1.01-1.60) increased risk was observed with the -31C-511T common haplotype. These findings indicate that these 2 IL-1beta promoter variants may contribute to risk of developing breast cancer in the Chinese population...
  31. ncbi Interleukin-1 gene polymorphisms and gastric cancer risk in a high-risk Italian population
    D Palli
    Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center CSPO, Scientific Institute of Tuscany, Florence, Italy
    Am J Gastroenterol 100:1941-8. 2005
    ..The aim of the study was to investigate the relationship between selected IL1 loci polymorphisms and gastric cancer risk in an Italian population...
  32. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  33. ncbi Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:399-407. 2006
    ..These observations suggest that the IL-1/IL-1Ra system is crucial for auto-antigen-specific T cell induction and contributes to the development of EAE...
  34. pmc Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts
    D O' Gradaigh
    Bone Research Group, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Ann Rheum Dis 63:354-9. 2004
    ..interactions activate bone resorption, this being attributed to tumour necrosis factor alpha (TNFalpha) and interleukin 1 beta (IL1beta) enhanced osteoblast expression of RANKL...
  35. pmc Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein
    C Gabay
    Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 99:2930-40. 1997
    b>Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions...
  36. ncbi Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease
    J J Powell
    Gastrointestinal Laboratory, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
    J Autoimmun 14:99-105. 2000
    ..In each case, the levels of interleukin 1 (IL-1) produced in these assays were quantitated by bioassay and by ELISA...
  37. ncbi IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
    Alissa A Chackerian
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, CA 94304, USA
    J Immunol 179:2551-5. 2007
    ..The implications of this shared usage of IL-1RAcP by IL-1(alpha and beta) and IL-33 are discussed...
  38. pmc Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
    Idan Cohen
    The Shraga Segal Department of Microbiology and Immunology and Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 107:2574-9. 2010
    ..Tissues surrounding the necrotic site also sustain damage from the myeloid cells. Nuclear trafficking and differential release during necrosis vs. apoptosis demonstrate that inflammation by IL-1alpha is tightly controlled...
  39. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
    ..Rather than being directly cytotoxic, IL-1beta may drive tissue inflammation that impacts on both beta cell functional mass and insulin sensitivity in type 2 diabetes...
  40. ncbi Rapid responses to anakinra in patients with refractory adult-onset Still's disease
    Avril A Fitzgerald
    University of Calgary, Calgary, Alberta, Canada
    Arthritis Rheum 52:1794-803. 2005
    ..To assess the efficacy of anakinra treatment in patients with adult-onset Still's disease (AOSD) that is refractory to corticosteroids, methotrexate (MTX), and etanercept...
  41. ncbi Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P
    Angel V Delgado
    Laboratory Support Branch, US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Neuropeptides 37:355-61. 2003
    ..In this study, we show the effect of Substance P on the production of Tumor Necrosis Factor-alpha, Interleukin 1-beta, Interleukin 2, and Interleukin 6 by T-lymphocytes, macrophages and neutrophils...
  42. ncbi A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
    N A Thornberry
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    Nature 356:768-74. 1992
    ..Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1 beta, indicating that it is a potential therapeutic target...
  43. ncbi Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway
    Thomas R Hawn
    Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Microbes Infect 4:763-71. 2002
    ..Examination of promoter activation is a powerful tool for understanding the early events in macrophage activation for anti-inflammatory pathogens such as Leishmania that have mechanisms to downregulate transcription and translation...
  44. pmc A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    Caroline Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1685-91. 2006
    ..Tumor necrosis factor alpha also synergized with IL-23 to enhance IL-17 production, and this was IL-1 dependent. Our findings demonstrate that IL-1 functions upstream of IL-17 to promote pathogenic ThIL-17 cells in EAE...
  45. pmc Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
    J A Corbett
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 90:1731-5. 1993
    ..In this report we demonstrate that the cytokine combination of human recombinant interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) induces the ..
  46. ncbi Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain
    Torben Glatz
    Institute of Experimental and Clinical Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Hypertens 28:1488-97. 2010
    ..We studied in rats the effects of the PPARgamma agonist, pioglitazone, on the regulation of IL-1beta, IL-1ra and IL-1 receptor I (IL-1RI) expression in ischaemic brain after occlusion of the middle cerebral artery for 90 min...
  47. ncbi Interleukin-1
    E Stylianou
    School of Medical and Surgical Sciences, University Hospital, Queen s Medical Centre, Nottingham, UK
    Int J Biochem Cell Biol 30:1075-9. 1998
    b>Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses...
  48. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, Quebec G1V 4G2, Canada
    Neuron 49:489-502. 2006
    ..Therapeutic strategies aiming to improve their recruitment could potentially lead to a new powerful tool for the elimination of toxic senile plaques...
  49. ncbi Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
    T L Born
    Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 273:29445-50. 1998
    ..We propose that although IL-1R-rp1 binds the cytokine, IL-1R-rp1 and AcPL proteins are both required for IL-18 signaling, analogous to the requirement for both IL-1R and IL-1RAcP in IL-1-mediated responses...
  50. ncbi Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells
    Z Guan
    Department of Medicine and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:28670-6. 1998
    ..This study suggests that the activation of both JNK/SAPK and p38 MAPK signaling cascades is required for IL-1beta-induced Cox-2 expression and PGE2 synthesis...
  51. ncbi Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia
    Y Aizawa
    Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
    Circulation 104:455-60. 2001
    ..We have investigated the role of pioglitazone in the apoptosis of vascular smooth muscle cells (VSMCs) in vitro and developed intimal hyperplasia in vivo...
  52. ncbi Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha
    Ting Ma
    Department of Orthopaedic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R144, Stanford, CA 94305 5341, USA
    Cytokine 26:138-44. 2004
    ..These results show that in the absence of stromal cells, IL-1 exacerbates osteoclastogenesis by cooperating with RANKL and M-CSF, while TNF-alpha is not involved in this IL-1-stimulated osteoclast differentiation pathway...
  53. ncbi Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 117:561-74. 2004
    ..Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation...
  54. pmc Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase
    Mark Windheim
    MRC Protein Phosphorylation Unit, College of Life Sciences, The Sir James Black Centre, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Cell Biol 28:1783-91. 2008
    b>Interleukin 1 (IL-1) has been reported to stimulate the polyubiquitination and disappearance of IL-1 receptor-associated kinase 1 (IRAK1) within minutes...
  55. pmc Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
    Philip Bufler
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    Biochem J 381:503-10. 2004
    IL-1F7b, a novel homologue of the IL-1 (interleukin 1) family, was discovered by computational cloning...
  56. ncbi Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways
    Chrystelle Garat
    Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center B115, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine 23:31-40. 2003
    ..This intracellular anti-inflammatory activity of icIL-1Ra1 was mediated through inhibition of p38 MAP kinase and NF-kappaB signal transduction pathways...
  57. ncbi Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis
    Brigit A de Jong
    Department of Clinical Epidemiology, LUMC, Leiden, The Netherlands
    J Neuroimmunol 126:172-9. 2002
    ..Taq1 polymorphism in the IL-1beta gene and the variable number of tandem repeats (VNTR) polymorphism of 86-base pairs within the IL-1Ra gene cannot explain these findings...
  58. ncbi A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function
    Allison P Armstrong
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 277:44347-56. 2002
    ..These studies are the first to define the functional domains of the RANK cytoplasmic tail that control specific differentiation and activation pathways in osteoclasts...
  59. ncbi Stimulation of macrophage migration inhibitory factor expression in endometrial stromal cells by interleukin 1, beta involving the nuclear transcription factor NFkappaB
    W G Cao
    Unite d Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada G1L 3L5
    Biol Reprod 73:565-70. 2005
    ..Herein we report that interleukin 1 (IL1), a major proinflammatory cytokine that is overproduced by endometriosis women-derived peritoneal ..
  60. ncbi IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas
    J S Wolf
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, 20892, USA
    Clin Cancer Res 7:1812-20. 2001
    ..We demonstrate that exogenous and endogenous IL-1alpha contributes to the transcriptional activation of NFkappaB and AP-1, to the expression of IL-8, and to cell survival and the growth of HNSCC in vitro...
  61. ncbi The role of interleukin 1 in growth and metastasis of human cancer xenografts
    Dina M Elaraj
    Surgical Metabolism Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1201, USA
    Clin Cancer Res 12:1088-96. 2006
    b>Interleukin 1 (IL-1) is a pluripotent cytokine that promotes angiogenesis, tumor growth, and metastasis in experimental models; its presence in some human cancers is associated with aggressive tumor biology...
  62. ncbi Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release
    Peter Thornton
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, UK
    J Neurochem 98:258-66. 2006
    ..Thus, IL-1 activates the IL-1 type 1 receptor in astrocytes to induce caspase-dependent neuronal death, which is dependent on the release of free radicals and may contribute to neuronal cell death in CNS diseases...
  63. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
    ..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
  64. ncbi Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene
    B S Taylor
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 273:15148-56. 1998
    ....
  65. ncbi Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation
    S A Reddy
    Department of Biochemistry and Molecular Biology, Box 117, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 272:29167-73. 1997
    ..Our results thus indicate that PI 3-kinase is a novel signal transducer in IL-1 signaling and that it may differentially mediate the activation of NFkappaB and AP-1...
  66. ncbi Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    Thirumala Devi Kanneganti
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Nature 440:233-6. 2006
    ..These results reveal a critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes...
  67. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  68. ncbi The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 59:489-93. 1996
    ....
  69. ncbi Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain
    Y B Guedez
    University of Tennessee, Memphis, USA
    Arthritis Rheum 44:2413-24. 2001
    ..Treatment of IFNgamma-/- mice with anti-IL-1beta significantly reduced the incidence and severity of the inflammation. CONCLUSION: Endogenous IFNgamma plays a role in the regulation of IL-1beta, in this model of autoimmune arthritis...
  70. ncbi Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages
    M Caivano
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, United Kingdom
    J Immunol 164:3018-25. 2000
    ..They also suggest that MSK1 and MSK2 may play a role in these processes and hence are potential targets for the development of novel antiinflammatory drugs...
  71. ncbi Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
    M B Teunissen
    Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Invest Dermatol 111:645-9. 1998
    ....
  72. ncbi PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts
    Marie Agn├Ęs Simonin
    Laboratoire de Pharmacologie, Unite Mixte de Recherche Centre National de la Recherche Scientifique 7561, 54505 Vandoeuvre les Nancy, France
    Am J Physiol Cell Physiol 282:C125-33. 2002
    ..These results offer new insights in regard to the anti-inflammatory potential of the PPAR-gamma ligands and underline different mechanisms of action of 15d-PGJ(2) and troglitazone in synovial fibroblasts...
  73. ncbi Distinct inflammatory mechanisms mediate early versus late colitis in mice
    David M Spencer
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    Gastroenterology 122:94-105. 2002
    ..We report a longitudinal study investigating changes in the mucosal immune response in an experimental model of colitis...
  74. ncbi Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion
    Petri Salven
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 16:1471-3. 2002
    ..This novel mechanism of IL-1alpha-action may enhance the shift to angiogenic phenotype in various conditions designated by excessive angiogenesis...
  75. ncbi Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke
    A Bouchama
    Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Appl Physiol (1985) 70:2640-4. 1991
    To determine whether endotoxemia and release of tumor necrosis factor (TNF-alpha) and/or interleukin 1 alpha (IL-1 alpha) are involved in the pathogenesis of heatstroke, 17 adult patients with a mean rectal temperature of 42.1 +/- 0...
  76. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  77. ncbi Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    Yaya Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Nat Immunol 7:139-47. 2006
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) is critical for mediating Toll-like receptor (TLR)-interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate ..
  78. pmc The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Neuroinflammation 5:7. 2008
    ..Potentially adaptive functions of IL-1 elevation in AD warrant further mechanistic studies, and provide evidence that enhancement of these effects may help to alleviate the pathologic burden of disease...
  79. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
    ..Moreover, NAC moderated LPS-induced IL-1 secretion partially via interleukin 1-converting enzyme...
  80. ncbi Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release
    J Michelle Kahlenberg
    Dept of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Physiol Cell Physiol 286:C1100-8. 2004
    ....
  81. pmc Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice
    Z Chai
    Department of Neurochemistry and Neurotoxicology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
    J Exp Med 183:311-6. 1996
    ..These results suggest that central IL-6 is a necessary component of the fever response to both endogenous (IL-1 beta) and exogenous (LPS) pyrogens in mice and that IL-6 acts downstream from both peripheral and central IL-1 beta...
  82. pmc The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
    Jennifer M McCoy
    Pfizer Global Research and Development, Department of Inflammation and Pathology, Groton, Connecticut 06340, USA
    J Clin Invest 110:651-8. 2002
    ..Thus, PGE2 contributes to disease progression at least in part by binding to the EP4 receptor. Antagonists of this receptor might therefore provide novel agents for the treatment of RA...
  83. ncbi Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice
    H Yamada
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
    Lab Invest 80:759-67. 2000
    ..Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection...
  84. ncbi Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Daniel J Cua
    Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
    Nature 421:744-8. 2003
    ..In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages...
  85. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
    ..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
  86. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
    ....
  87. ncbi Altered cytokine production in mice lacking P2X(7) receptors
    M Solle
    Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
    J Biol Chem 276:125-32. 2001
    ..Together these results demonstrate that P2X(7)R activation can provide a signal that leads to maturation and release of IL-1 beta and initiation of a cytokine cascade...
  88. ncbi Rapid secretion of interleukin-1beta by microvesicle shedding
    A Mackenzie
    Institute of Molecular Physiology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Immunity 15:825-35. 2001
    ..We conclude that microvesicle shedding is a major secretory pathway for rapid IL-1beta release from activated monocytes and may represent a more general mechanism for secretion of similar leaderless secretory proteins...
  89. pmc Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    Cristina Andrei
    Cell Transport Unit, Department of Oncogenesis, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:9745-50. 2004
    ..This activation is ultimately responsible for lysosome exocytosis and IL-1 beta secretion...
  90. ncbi Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism
    Yasuhiro Yoshida
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 279:1768-76. 2004
    ..These data argue for a novel transcription factor cross-talk mechanism that may help resolve inconsistencies previously reported regarding the mechanism of IL-1 inhibition of IL-6 activity during the acute-phase response...
  91. pmc Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells
    Min Sun Kim
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Metabolism 56:267-79. 2007
    ..Here we demonstrate that tumor necrosis factor (TNF) and interleukin 1 (IL-1), but not IL-6, decrease the expression of retinoid X receptor alpha (RXRalpha), peroxisome proliferator-..
  92. ncbi Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways
    H Y Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Biol Chem 276:28719-30. 2001
    ..low density lipoprotein (OxLDL), and fucoidan induction of the cytokines tumor necrosis factor-alpha (TNF) and interleukin 1 beta (IL-1). In brief, in murine macrophages J774A...
  93. ncbi Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    Nathalie Busso
    Laboratory of Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunol 168:875-82. 2002
    ..In conclusion, leptin contributes to the mechanisms of joint inflammation in Ag-induced arthritis by regulating both humoral and cell-mediated immune responses...
  94. ncbi Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
    J R Jackson
    Department of Immunopharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Pharmacol Exp Ther 284:687-92. 1998
    ..Thus, this p38/CSBP MAP kinase inhibitor, which can reduce inflammatory cytokine production and inhibit angiogenesis, is an effective treatment for chronic proliferative inflammatory disease...
  95. pmc Defective inflammatory response in interleukin 6-deficient mice
    E Fattori
    Istituto di Ricerche di Biologia Molecolare IRBM P Angeletti, Pomezia, Roma
    J Exp Med 180:1243-50. 1994
    ..Our results reinforce the idea that different patterns of cytokines are involved in systemic and localized tissue damage, and identify IL-6 as an essential mediator of the inflammatory response to localized inflammation...
  96. ncbi Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
    M G De Simoni
    Laboratory of Inflammation and Nervous System Diseases and Laboratory of Experimental Neurology, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Eur J Neurosci 12:2623-33. 2000
    ..These changes may play an active role in hyperexcitability of the epileptic tissue...
  97. ncbi The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Immunol 169:1459-66. 2002
    ..Because arthritis was also developed in SCID mice, the development of arthritis in the Ab-induced mice model is due to a mechanism that does not involve T or B cells...
  98. ncbi Interleukin 1B gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in Helicobacter pylori-negative gastric cancer of intestinal and diffuse histotype
    A Ruzzo
    Institute of Biochemistry G Fornaini, University of Urbino, Italy
    Ann Oncol 16:887-92. 2005
    Polymorphisms in the interleukin 1beta gene (IL-1B-31T/C and IL-1B-511C/T single nucleotide changes) and in the interleukin 1 receptor anatagonist gene (IL-1RN2 variable number of tandem repeats) have been studied with respect to gastric ..
  99. pmc An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    N Engl J Med 360:2426-37. 2009
    ..We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone...
  100. ncbi Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
    H Anisman
    Institute of Neurosciences, Carleton University, Ottawa, Ontario, Canada
    Mol Psychiatry 4:182-8. 1999
    ..Given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features, a role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression...
  101. ncbi Structure and mechanism of interleukin-1 beta converting enzyme
    K P Wilson
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139
    Nature 370:270-5. 1994
    ..The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation...

Research Grants69

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  2. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
    ....
  3. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  4. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..At present there are no approved prophylactic measures. We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in two clinically-relevant animal models. ..
  5. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..R-801 therapy is expected to translate into decreased primary graft dysfunction and mortality after lung transplant. ..
  6. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  7. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ....
  8. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ....
  9. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..Nearly one-half of patient beginning dialysis for CKD were e65 yo. We propose to study inflammatory and vascular injury and cell death and the effects of potential therapies in a model of CKD. ..
  10. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    ....
  11. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..This will decrease the number of islets required to achieve normoglycemia in type I diabetic patients. ..
  12. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..This proposal will provide mechanistic insight into how TAX1BP1, Itch and A20 function together to inactivate key signaling molecules and restrict inflammatory signaling pathways. ..
  13. Novel Functions of S1P in Neuroinflammation
    TOMASZ K KORDULA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interleukin 1 (IL-1) is a proinflammatory cytokine that is critical for the development and progression of multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in ..
  14. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    ..In the Pathways Study, we now have an exceptional opportunity to address an important gap in breast cancer survivorship research, and to reduce the burden of AI-induced osteoporotic fractures in a real-world clinical setting. ..
  15. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..investigation of the modulation of TRPV4 activity by activation of proteinase-activated-receptor 2 (PAR-2), interleukin 1, leptin, or prostaglandin E2;and 2) Using gene-targeted mice, to determine the effects of inducible, cartilage-..
  16. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..Generation of nitric oxide and of cytokines such as tumor necrosis factor-alpha and interleukin 1-beta are associated with early progression of APAP hepatotoxicity, and PAR-1 activation of nonparenchymal ..
  17. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..studies demonstrated that meprins are also capable of producing biologically active proinflammatory cytokine interleukin 1-2 from its inactive proform and proteolytically processing chemotactic cytokine MCP-1, suggesting that meprins ..
  18. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
    ..An improved understanding of how these toxins cause disease is necessary to formulate effective therapeutic agents to block disease progression. ..
  19. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    Addanki P Kumar; Fiscal Year: 2012
    ....
  20. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013
    ..This study aims to establish a basic mechanism common to manual and movement-based therapies that will strengthen the rationale for these treatments. ..
  21. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors. ..
  22. Role of Interleukin-1 in mediating epithelial-dendritic cell crosstalk in the lun
    BART N contact LAMBRECHT; Fiscal Year: 2010
    ..This project will help unravel how individuals become allergic when exposed to house dust mite allergen. ..
  23. Functional impact of IL33 polymorphisms on asthma &other Th2-mediated diseases
    Kathleen C Barnes; Fiscal Year: 2013
    ..IL-33 is a new member of the IL-1 family that induces Th2 cytokines. Its receptor, interleukin 1-like (or ST2) exists as membrane and circulating soluble proteins, and ST2 polymorphisms were also associated ..
  24. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..Our findings may open new avenues regarding the use of PFE or compounds derived from it for the treatment and/or prevention of OA. ..
  25. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..Knowledge of interactions between the ENS and inflammatory effectors, therefore, has the potential to transform understanding and, ultimately, treatment of many intestinal disorders. ..
  26. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Development of highly specific imaging agents for noninvasive detection of inflammation induced by heart attacks. ..
  27. Role of Pellino1 in liver inflammation
    Liselotte E Jensen; Fiscal Year: 2010
    ..An improved understanding of liver inflammation and the associated molecular pathways may facilitate the development of novel therapies for hepatitis and liver cancer. ..
  28. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..In addition, it may provide the potential for novel therapeutic targets in Crohn's disease and possibly other forms of inflammatory bowel disease. ..
  29. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ....
  30. Meprin A Metalloproteinase in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..studies demonstrated that meprins are also capable of producing biologically active proinflammatory cytokine interleukin 1-beta from its inactive proform and proteolytically processing chemotactic cytokine MCP-1, suggesting that ..
  31. Inflammasome activation by a respiratory virus
    Christopher M Wiethoff; Fiscal Year: 2010
    ....
  32. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..Should the positive effects of augmented exercise on body composition be supported, we would then anticipate widespread benefit in preventing long-term health consequences of prematurity at relatively low cost. ..
  33. Toll-like receptor mediated regulation of effector and memory CD4 T cell response
    Chandrashekhar Pasare; Fiscal Year: 2013
    ..The knowledge acquired from these studies will aid in development of new vaccination strategies against pathogens ..
  34. Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
    Talat Alp Ikizler; Fiscal Year: 2013
    ..abstract_text> ..
  35. A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathy
    Daniela Salvemini; Fiscal Year: 2013
    ..Given the breadth of disorders impacted by A3AR agonists understanding their mechanism-based effects has far-reaching basic science &clinical implications. ..
  36. Biomarker of Tissue Tolerance and Behavior in a Rat Model of WMSD
    Mary F Barbe; Fiscal Year: 2013
    ..abstract_text> ..
  37. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ....
  38. Anti-Inflammatory Interventions in Maintenance Hemodialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2013
    ....
  39. Mesenchymal stem cell secretome in lung fibrosis: mitochondria and RNA shuttle
    Luis A Ortiz; Fiscal Year: 2013
    ..Finally, we will determine whether transfer of mitochondria occurs in the lung of silica-exposed mice. ..
  40. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2013
    ..Results will have practical application to IL1-associated brain pathologies including inflammation-associated sleep disturbances occurring in sleep apnea and metabolic syndrome. ..
  41. Micro RNA-146a (miRNA-146a) signaling in Alzheimers disease (AD)
    Walter J Lukiw; Fiscal Year: 2013
    ....
  42. Role of the Prolyl Isomerase Pin1 in the Development and Treatment of Asthma
    Kun Ping Lu; Fiscal Year: 2013
    ..These studies would uncover a novel mechanism in asthma development, and also could lead to more effective therapies because Pin1 inhibitors, especially when inhaled, might inhibit multiple targets in different cells in asthma. ..
  43. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  44. ESE 1 a novel transcriptional regulator of cartilage remodeling
    MARY GOLDRING; Fiscal Year: 2009
    ..Project Description ..
  45. Understanding early events in lupus autoimmunity to aid prevention
    Judith A James; Fiscal Year: 2013
    ....
  46. Interleukin-33 and Myocardial Pressure Overload
    Richard T Lee; Fiscal Year: 2013
    ..This proposal addresses a newly-discovered signaling system in the heart that is activated by overloading the heart muscle. Understanding this signaling system could lead to new therapies for preventing heart failure. ..
  47. Mechanisms of Protein Kinase Activation by Ubiquitin in the NF-kB Pathways
    Zhijian J Chen; Fiscal Year: 2013
    ..If successful, our research should reveal the fundamental mechanisms of NF-kB activation in immune and inflammatory responses and provide potential new approaches to inhibit aberrant NF-kB activation in human diseases. ..
  48. Interleukin-1 (IL-1) Receptor-Mediated Modulation of Serotonin Transporters
    Randy D Blakely; Fiscal Year: 2011
    ....
  49. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..Results from this study may also help to identify more clearly the biological causes for common, distressing symptoms. ..
  50. Role of the MyD88-independent pathway in Alzheimers disease
    Ken Ichiro Fukuchi; Fiscal Year: 2013
    ..The long term goals of this research are to determine the roles of TLR signaling in AD progression and to establish the logical basis for developing safe and effective immunotherapy for AD. ..
  51. Role of HOS in cell transformation and apoptosis
    Serge Y Fuchs; Fiscal Year: 2013
    ..cells can accelerate IFNAR1 degradation and inhibit IFN1 signaling by secreting inflammatory cytokines such as interleukin 1 (IL1)...
  52. The Role of Oxidative Stress in Systemic Amyloidosis
    Steven R Zeldenrust; Fiscal Year: 2010
    ..abstract_text> ..
  53. Intrinsic Repair of the Knee Meniscus
    Farshid Guilak; Fiscal Year: 2011
    ..NO and PGE2 in regulating collagen synthesis;(3) determine the interaction of mechanical stress with interleukin 1, interleukin 17, and tumor necrosis factor alpha in the production of pro-inflammatory mediators, and (4) ..
  54. Interleukin-1 blockade in recently decompensated heart failure
    Benjamin W Van Tassell; Fiscal Year: 2013
    ..Results from this pilot study will be used to optimize the treatment strategy and design a subsequent phase III clinical trial to evaluate long-term morbidity and mortality with IL-1 blockade in HF patients. ..
  55. Effects of Neuroinflammation on Gap Junction Communication in Glia
    TAMMY L KIELIAN; Fiscal Year: 2010
    ..These experiments will provide meaningful insights into how proinflammatory mediators influence the extent of glial GJC in brain abscess. ..
  56. PROGERIN ENDOTHELIAL DYSFUNCTION AND VASCULAR DISEASE
    Michael A Gimbrone; Fiscal Year: 2013
    ....
  57. Post-transcriptional control of inflammatory gene expression
    Thomas A Hamilton; Fiscal Year: 2013
    ..This proposal is focused upon understanding the mechanisms through which IL-17 (and other stimuli) controls degradation of specific inflammation related messenger RNAs and thereby modulates aspects of inflammatory response. ..
  58. Investigating the role of ROCK1 in epithelial cell inflammatory responses
    Dennis W McGee; Fiscal Year: 2010
    ..Knowledge of this novel regulation of the pathway will provide insight into potential therapies that could control epithelial cell barrier function and participation in intestinal inflammatory responses. ..
  59. Involvement of Leptin and Interleukin-1 Signaling in Mammary Cancer Progression
    RUBEN RENE GONZALEZ-PEREZ; Fiscal Year: 2012
    ..Inhibition of leptin signaling in such instances might serve as a preventative or adjuvant measure. ..
  60. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ....
  61. Cytokine Gene Polymorphism in CRIC Cohort
    DOMINIC S RAJ; Fiscal Year: 2010
    ..Significance: Identification of the high risk genotypes can lead to early and aggressive interventions aimed at the target population. ..
  62. The Importance of Temperature on Inflammation after TBI
    W Dalton Dietrich; Fiscal Year: 2013
    ..The proposed studies will provide novel information regarding the development of seizures after TBI and determine how hypothermia therapy may improve this debilitating consequence of TBI. ..
  63. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
  64. CONTROL OF HEMATOPOIETIC TOXICITY WITH INTERLEUKIN-1
    VINCENT GALLICCHIO; Fiscal Year: 1990
    ..Toward this long-term goal to develop a specific agent(s) that may either enhance the recovery of blood cell production or reduce hematopoietic damage as the result of chemotherapy, therefore, may have important clinical applications...
  65. EFFECTS OF PHORBOL ESTERS ON LYMPHOCYTE STIMULATION
    Andrea Mastro; Fiscal Year: 1991
    ..Mitogenic lectins along with macro-phages induce production of interleukin 1 (IL1), interleukin 2 (IL2), and their receptors which interact to cause proliferation...
  66. CYTOKINE REGULATION OF UTERINE OXYTOCIN RECEPTOR
    PHILLIP RAUK; Fiscal Year: 2001
    ..The antagonism of IL-1 by IL-lra and TGF beta will be studied. A detailed understanding of the regulation of uterine oxytocin receptors will increase the overall understanding of mechanisms of labor. ..
  67. NEUROTRANSMITTERS AND CYTOKINES IN TOOTH MOVEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1992
    ..P, vasoactive intestinal peptide, methionine-enkephalin, calcitonin gene- related peptide and the cytokines Interleukin 1 alpha, 1 beta, Interleukin 2, interferon-gamma and tumor necrosis factor-alpha; 2) assess the effects of each ..
  68. PATHOGENESIS AND PATHOPHYSIOLOGY OF BACTERIAL MENINGITIS
    WILLIAM SCHELD; Fiscal Year: 1991
    ..These two specific aims are closely related and examine microorganism-BBB interactions after, and before bacterial entry into the SAS, respectively...
  69. MOLECULAR MECHANISM OF TAT INDUCED ANGIOGENESIS
    Cindy Morris; Fiscal Year: 2002
    ....