interferon alpha

Summary

Summary: One of the type I interferons (INTERFERON TYPE I) produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products. It is the major interferon produced by virus-induced leukocyte cultures and, in addition to its pronounced antiviral activity, it causes activation of NK cells.

Top Publications

  1. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
  2. ncbi Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    N Engl J Med 356:115-24. 2007
  3. ncbi Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    Akinori Takaoka
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 424:516-23. 2003
  4. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
  5. ncbi Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    Gary Hudes
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    N Engl J Med 356:2271-81. 2007
  6. ncbi A weak signal for strong responses: interferon-alpha/beta revisited
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Rev Mol Cell Biol 2:378-86. 2001
  7. ncbi Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma: a randomized clinical trial
    Hui Chuan Sun
    Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People s Republic of China
    J Cancer Res Clin Oncol 132:458-65. 2006
  8. pmc Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions
    L Farkas
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 159:237-43. 2001
  9. pmc Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /beta
    C Manca
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:5752-7. 2001
  10. ncbi Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)
    Ghada Kchour
    Immunology Research Centre, Bu Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
    Blood 113:6528-32. 2009

Detail Information

Publications314 found, 100 shown here

  1. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8...
  2. ncbi Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    N Engl J Med 356:115-24. 2007
    ..Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warranted...
  3. ncbi Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    Akinori Takaoka
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 424:516-23. 2003
    ..Our study reveals a hitherto unrecognized link between p53 and IFN-alpha/beta in tumour suppression and antiviral immunity, which may have therapeutic implications...
  4. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  5. ncbi Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    Gary Hudes
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    N Engl J Med 356:2271-81. 2007
    ..Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, may benefit patients with this disease...
  6. ncbi A weak signal for strong responses: interferon-alpha/beta revisited
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Rev Mol Cell Biol 2:378-86. 2001
    ..What is the purpose of the constitutive weak interferon-alpha/beta signal?..
  7. ncbi Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma: a randomized clinical trial
    Hui Chuan Sun
    Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People s Republic of China
    J Cancer Res Clin Oncol 132:458-65. 2006
    ..This study evaluated the effect of postoperative interferon alpha (IFN alpha) treatment on recurrence and survival in patients with hepatitis B virus (HBV)-related HCC.
  8. pmc Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions
    L Farkas
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 159:237-43. 2001
    ..Together, our findings suggested that P-DCs are an important source of IFN-alpha/beta in cutaneous LE lesions and may therefore be of pathogenic importance...
  9. pmc Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /beta
    C Manca
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:5752-7. 2001
    ..In addition, the lack of development of Th1 immunity in response to HN878 appears to be associated with increased induction of Type 1 IFNs...
  10. ncbi Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)
    Ghada Kchour
    Immunology Research Centre, Bu Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
    Blood 113:6528-32. 2009
    ..Long-term follow up will clarify whether this will translate to disease cure. Overall, these clinical results strengthen the concept of oncogene-targeted cancer therapy...
  11. ncbi Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 176:4682-9. 2006
    ..The finding that T cells represent direct targets of IFN-alphabeta-mediated stimulation reveals an additional mechanism by which the innate response to infection promotes adaptive immunity...
  12. ncbi Regulation of the type I IFN induction: a current view
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Int Immunol 17:1367-78. 2005
    ..The understanding of the regulatory mechanisms of IFN-alpha/beta gene induction by TLRs and viruses is an emerging theme, for which much new insight has been gained over the past few years...
  13. ncbi Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:906-14. 2003
    ..Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme, indoleamine-2,3-dioxygenase, during immune activation may contribute to development of depressive symptoms during interferon (IFN)-alpha therapy...
  14. ncbi Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis
    Simone Mocellin
    Clinica Chirurgica Generale 2, Department of Oncological and Surgical Sciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    J Natl Cancer Inst 102:493-501. 2010
    Based on previous meta-analyses of randomized controlled trials (RCTs), the use of interferon alpha (IFN-alpha) in the adjuvant setting improves disease-free survival (DFS) in patients with high-risk cutaneous melanoma...
  15. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
    ....
  16. ncbi Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    H Hochrein
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 166:5448-55. 2001
    ..In contrast, the CD4(-)8(-) DC produced much more IFN-gamma than the CD4(-)8(+) or the CD4(+)8(-) DC under all conditions tested...
  17. ncbi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
    ..Vpu co-localized with CD317 and inhibited these effects. Inhibition of Vpu function and consequent mobilization of tetherin's antiviral activity is a potential therapeutic strategy in HIV/AIDS...
  18. ncbi Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity
    Lena Thyrell
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Hospital and Institute, S 171 76 Stockholm, Sweden
    Exp Cell Res 313:4015-24. 2007
    ..b>Interferon alpha (IFNalpha) treatment of cell lines derived from multiple myeloma or of myeloma tumor cells ex vivo leads to ..
  19. ncbi Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis
    Patrizia Farci
    Dipartimento di Scienze Mediche, Universita di Cagliari, SS 554 Bivio Sestu, 09042 Cagliari, Italy
    Gastroenterology 126:1740-9. 2004
    Little is known about the long-term effects of interferon alpha on clinical outcome and survival of patients with chronic hepatitis D.
  20. ncbi The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells
    F Le Roy
    EP2030 CNRS, Institut de Genetique Moleculaire, 1919 Route de Mende, 34293 Montpellier, France
    J Biol Chem 276:48473-82. 2001
    b>Interferon alpha (IFNalpha) belongs to a cytokine family that exhibits antiviral properties, immuno-modulating effects, and antiproliferative activity on normal and neoplasic cells in vitro and in vivo...
  21. ncbi Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway
    Sathit Pichyangkul
    Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    J Immunol 172:4926-33. 2004
    ....
  22. ncbi Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    Science 315:1398-401. 2007
    ..These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7...
  23. pmc Irreversible pulmonary hypertension associated with the use of interferon alpha for chronic hepatitis C
    Sonu Dhillon
    Department of Medicine, Rush University Medical Center, Ste 158 Professional Building, Chicago, IL 60612, USA
    Dig Dis Sci 55:1785-90. 2010
    ..present four cases in which irreversible pulmonary hypertension was diagnosed after prolonged treatment with interferon alpha. In each case, other causes of pulmonary hypertension were systematically eliminated...
  24. ncbi Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes
    B J Barnes
    Oncology Center and the Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 276:23382-90. 2001
    ..These data indicate that multiple signaling pathways induced by infection may be differentially recognized by members of the IRF family and modulate transcription of individual IFNA genes in a virus and cell type-specific manner...
  25. ncbi Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma
    Brian I Rini
    Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Cancer 106:566-75. 2006
    ..Based on potential additive or synergistic antitumor effects, interferon-alpha (IFNalpha) and celecoxib, an oral COX-2 inhibitor, were given to metastatic RCC patients in a Phase II trial...
  26. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  27. ncbi MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo
    Thomas Delale
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Immunol 175:6723-32. 2005
    ....
  28. ncbi Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
    Judith N Mandl
    Graduate Program in Population Biology, Ecology and Evolution, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Med 14:1077-87. 2008
    ..Such a vicious cycle of continuous virus replication and immunopathology is absent in natural sooty mangabey hosts...
  29. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
    ..Therefore, these results demonstrate a novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-alpha by pDCs...
  30. ncbi Host factors and failure of interferon-alpha treatment in hepatitis C virus
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Hepatology 39:880-90. 2004
    ..We discuss possible underlying mechanisms responsible for these effects. Potential therapeutic strategies to enhance the effectiveness of IFN-alpha therapy for HCV are also proposed...
  31. ncbi Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta
    K Sato
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 31:3138-46. 2001
    ..Thus, our study reveals a new molecular link between IFN-alpha/beta signaling and activation of NK cells in antiviral response of the host...
  32. pmc Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
    Marcel Asper
    Department of Virology, Bernhard Nocht Institute of Tropical Medicine, 20359 Hamburg, Germany
    J Virol 78:3162-9. 2004
    ..Both cytokines inhibit replication which is relevant for the design of antiviral strategies against Lassa fever with the aim of enhancing the IFN response...
  33. ncbi Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    Taro Kawai
    ERATO, Akira Innate Immunity Program, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 5:1061-8. 2004
    ..These results indicate that TLR-mediated IFN-alpha induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination...
  34. pmc Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Tania Mara Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 49:1847-58. 2009
    ..51; P = 0.05) and a strong relationship among African American patients; all 10 with SVR who were genotyped for TYK2 -2256 carried the A variant compared with 68 of 120 (57%) nonresponders (P = 0.006)...
  35. ncbi Cell type-specific involvement of RIG-I in antiviral response
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Immunity 23:19-28. 2005
    ..In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner...
  36. pmc Neurons produce type I interferon during viral encephalitis
    Sophie Delhaye
    Microbial Pathogenesis Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, MIPA VIRO 74 49, 74, Avenue Hippocrate, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 103:7835-40. 2006
    ..Our data show that, in vivo, neurons take an active part to the antiviral defense by being both IFN-alpha/beta producers and responders...
  37. ncbi IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities
    Mohamad Mohty
    Laboratoire d Immunologie des Tumeurs, Institut Paoli Calmettes, Universite de la Mediterranee, and Institut National de la Santé et de la Recherche Médicale Unité 119, Marseille, France
    J Immunol 171:3385-93. 2003
    ..Taken together, these results illustrate the critical role of IFN-alpha at the early steps of immune response to pathogens or in autoimmune diseases...
  38. pmc The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha
    K S Khabar
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia 11211, USA
    J Exp Med 186:1077-85. 1997
    ..Understanding pathways that antagonize IFN action may lead to novel approaches to potentiate endogenous and therapeutic IFN...
  39. ncbi Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency
    Sonali K Sanghavi
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 175:5314-23. 2005
    ....
  40. ncbi Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help
    Hendrik Poeck
    Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig Maximilians University of Munich, Germany
    Blood 103:3058-64. 2004
    It has been reported that interferon alpha (IFN-alpha) enhances humoral immunity and that dendritic cells of the myeloid lineage promote B-cell differentiation...
  41. ncbi CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    Lawrence R Shiow
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 440:540-4. 2006
    ..Several mediators of the innate immune system are known to cause shutdown, including interferon alpha/beta (IFN-alpha/beta) and tumour necrosis factor, but the mechanism has been unclear...
  42. ncbi Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cells
    Miren Kerkmann
    Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig Maximilians University of Munich, 80336 Muenchen, Germany
    J Biol Chem 280:8086-93. 2005
    ..Based on these results we propose a model in which the spatial configuration of CpG motifs as particle is responsible for the virus-like potency of CpG-A to induce IFN-alpha in PDC...
  43. ncbi Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes
    Betsy J Barnes
    Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21231, USA
    J Biol Chem 278:16630-41. 2003
    ....
  44. pmc Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence
    Brian C Keller
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
    J Virol 80:9424-34. 2006
    ..Consistent with this finding, the virulence of MAD78 was unmasked upon infection of mice lacking IFNAR. Thus, control of the innate host response and IFN actions is a key feature of WNV pathogenesis and replication fitness...
  45. ncbi Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma
    J Steitz
    Department of Dermatology, J. Gutenberg University, D-55101 Mainz, Germany
    Cancer Res 61:8643-6. 2001
    ..These results support the development of novel strategies for the immunotherapy of melanoma using IFN alpha in combination with elimination of regulatory T cells or antigen-specific immunization...
  46. pmc Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin
    Theocharis Panaretakis
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Hospital and Institute, S 171 76 Stockholm, Sweden
    Mol Biol Cell 19:41-50. 2008
    ....
  47. pmc Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Lakeside Veterans Administration Medical Center, Section of Hematology Oncology, University of Chicago, IL, USA
    Blood 106:2436-43. 2005
    The precise mechanisms by which imatinib mesylate (STI571) and interferon alpha (IFNalpha) exhibit antileukemic effects are not known...
  48. pmc Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
    L P Cousens
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Exp Med 189:1315-28. 1999
    ....
  49. ncbi Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Berlin, Germany
    Hepatology 37:443-51. 2003
    ..Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting...
  50. ncbi Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt
    C H Yang
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 276:13756-61. 2001
    ..Therefore, STAT3, PI-3K, and Akt are components of an IFN signaling pathway that promotes cell survival through NF-kappaB activation...
  51. ncbi Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis
    Zofia Von Marschall
    Department of Hepatology, Gastroenterology, Endocrinology and Metabolism, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    J Natl Cancer Inst 95:437-48. 2003
    b>Interferon alpha (IFN-alpha) has antiangiogenic activity, although the underlying mechanism of action is unclear...
  52. ncbi IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells
    Linda Hibbert
    Department of Discovery Biology, DNAX Research Institute, Palo Alto, CA 94304, USA
    J Interferon Cytokine Res 23:513-22. 2003
    ..We propose that IL-27 and IFN-alpha are important for early Th1 commitment and act upstream of IL-12 and IFN-gamma in this pathway...
  53. pmc Inhibition of toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus
    Jörg Schlender
    Max von Pettenkofer Institute and Gene Center, Feodor Lynen Str 25, D 81377 Munich, Germany
    J Virol 79:5507-15. 2005
    ..The capacity of RSV and measles virus of human PDC to shut down IFN production should contribute to the characteristic features of these viruses, such as Th2-biased immune pathology, immune suppression, and superinfection...
  54. pmc Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy
    S J Polyak
    Department of Laboratory Medicine, Virology Division, University of Washington, 325 9th Ave, Seattle, WA 98104 2499, USA
    J Virol 75:6209-11. 2001
    ..This study suggests that HCV-induced changes in levels of chemokine and cytokine expression may be involved in HCV antiviral resistance, persistence, and pathogenesis...
  55. pmc Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients
    Clara Lehmann
    Institute of Human Virology, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11110. 2010
    ..cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha (IFNalpha), which is associated with HIV-1 disease progression...
  56. pmc Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression
    Jennifer C Felger
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Biol Psychiatry 62:1324-33. 2007
    ..To establish a nonhuman primate model of cytokine-induced depression, we examined the effects of IFN-alpha on rhesus monkeys...
  57. ncbi Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration
    Y Akwa
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 161:5016-26. 1998
    ..These transgenic mice provide a novel animal model in which to further evaluate the mechanisms that underlie the diverse actions of type I IFNs in the intact CNS...
  58. pmc Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes
    Betsy J Barnes
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cell Biol 22:5721-40. 2002
    ..It also shows that the range of IRF-5 immunoregulatory target genes includes members of the cytokine and chemokine superfamilies...
  59. ncbi Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG
    Tanja Lövgren
    Immunology V, Biomedical Center, Uppsala University, Uppsala, Sweden
    Arthritis Rheum 50:1861-72. 2004
    ....
  60. ncbi Interferon-alpha as an immunotherapeutic protein
    Diana L Brassard
    Bioanalytical Development, Schering Plough Research Institute, Union, New Jersey 07083, USA
    J Leukoc Biol 71:565-81. 2002
    ..This review will describe the current state of knowledge of IFN-alpha as an immunoregulatory protein and address specific issues of IFN-alpha as an immunotherapeutic for antineoplastic and antiviral diseases...
  61. pmc Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells
    Akihito Yonezawa
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Virol 77:3777-84. 2003
    ..In conclusion, these data strongly suggest that IPC can directly recognize and respond to HIV-1 with IFN-alpha production, which is crucial for preventing progress of HIV-1 infection and occurrence of opportunistic infection...
  62. ncbi High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-alpha and TLR ligands
    Arunee Thitithanyanont
    Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    J Immunol 179:5220-7. 2007
    ..Addition of this cytokine to monocyte-derived DC or pretreatment with TLR ligands protected against infection and the cytopathic effects of H5N1 virus...
  63. pmc The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12
    Béatrice Vanbervliet
    Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP 11, 69571 Dardilly, France
    J Exp Med 198:823-30. 2003
    ..Here we show that the migration of human plasmacytoid DCs (pDCs), the blood natural interferon alpha-producing cells, is induced upon the collective action of inducible and constitutive chemokines...
  64. pmc The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor
    M C Gauzzi
    Institut Pasteur, Institut National de la Santé et de la Recherche Médicale Unité 276, Paris 75724 Cedex 15, France
    Proc Natl Acad Sci U S A 94:11839-44. 1997
    ....
  65. pmc Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells
    Edward P Browne
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 100:11439-44. 2003
    ..Together, these results imply that pp65, which is delivered to newly infected cells in the virion, antagonizes a pathway that affects NF-kappaB and IRF1 and prevents the accumulation of mRNAs encoded by numerous cellular antiviral genes...
  66. pmc The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation
    K M Shah
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, Birmingham, UK
    Oncogene 28:3903-14. 2009
    ..This function may form part of EBV's strategy to limit anti-viral responses and define a novel function for LMP2A and LMP2B in modulating signalling from receptors that participate in innate immune responses...
  67. ncbi Regulation and function of IKK and IKK-related kinases
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Sci STKE 2006:re13. 2006
    ..Together, the IKKs and IKK-related kinases are instrumental for activation of the host defense system. This Review focuses on the functions of IKK and IKK-related kinases and the molecular mechanisms that regulate their activities...
  68. ncbi Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    M A Meraz
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 84:431-42. 1996
    ..These observations document that STAT1 plays an obligate and dedicated role in mediating IFN-dependent biologic responses and reveal an unexpected level of physiologic specificity for STAT1 action...
  69. ncbi The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Solution Oriented Research for Science and Technology, Japan Science and Technology Corp, Suita, Osaka, Japan
    J Immunol 170:3059-64. 2003
    ..This study demonstrates that the TLR9-MyD88 signaling pathway is essential for all DC responses to both types of CpG DNAs...
  70. ncbi Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: A review
    E Dieperink
    Department of Psychiatry, University of Minnesota and Minneapolis VA Medical Center 55417, USA
    Am J Psychiatry 157:867-76. 2000
    ..This review summarizes current knowledge about the etiology, course, and treatment of neuropsychiatric problems associated with hepatitis C and interferon alpha (IFN-alpha) treatment.
  71. ncbi Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells
    Yutaro Kumagai
    World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan
    J Immunol 182:3960-4. 2009
    ..These results showed that detection of viruses via TLRs together with a type I IFN feedback system circumvents the requirement for viral replication-dependent recognition in pDCs...
  72. ncbi Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN
    N Kadowaki
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 166:2291-5. 2001
    ....
  73. ncbi Mycophenolic acid inhibits hepatitis C virus replication and acts in synergy with cyclosporin A and interferon-alpha
    Scot D Henry
    Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 131:1452-62. 2006
    ..Cyclosporine A (CsA) specifically inhibits HCV replication through blocking the viral RNA polymerase enzyme NS5B. In this study, we investigated the effect of mycophenolic acid (MPA) and other immunosuppressants on HCV replication...
  74. ncbi Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
    Arya Biragyn
    Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Science 298:1025-9. 2002
    ..These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens...
  75. ncbi Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
    David Vremec
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 109:1165-73. 2007
    ..However, IKDCs, which efficiently produced IFN-gamma and showed immediate cytotoxicity on NK target cells, did not produce IFN-alpha under these conditions...
  76. ncbi Two subsets of dendritic cells are present in human cerebrospinal fluid
    M Pashenkov
    Division of Neurology, Karolinska Institutet, Huddinge University Hospital, R54, SE 14186 Huddinge, Sweden
    Brain 124:480-92. 2001
    ..Myeloid and plasmacytoid dendritic cells in CSF may contribute to orchestration of the local immune responses...
  77. ncbi IFN-alpha-conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens
    Caterina Lapenta
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 36:2046-60. 2006
    ..These results suggest that IFN-DC are directly licensed for an efficient CD8(+) T cell priming by mechanisms likely involving enhanced antigen presentation and special attitude to produce IL-12 family cytokines...
  78. ncbi Adjuvant interferon in high-risk melanoma: the AIM HIGH Study--United Kingdom Coordinating Committee on Cancer Research randomized study of adjuvant low-dose extended-duration interferon Alfa-2a in high-risk resected malignant melanoma
    B W Hancock
    Academic Unit of Clinical Oncology, The University of Sheffield, Weston Park Hospital, Whitham Rd, Sheffield S10 2SJ, UK
    J Clin Oncol 22:53-61. 2004
    ..To evaluate low-dose extended duration interferon alfa-2a as adjuvant therapy in patients with thick (> or = 4 mm) primary cutaneous melanoma and/or locoregional metastases...
  79. pmc Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B
    Karl W Boehme
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 78:1202-11. 2004
    ..Taken together, our findings reveal that CMV initiates a coordinated antiviral response through contact between gB and an as-yet-unidentified cell surface receptor(s)...
  80. pmc Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1
    Angela Meier
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA
    Nat Med 15:955-9. 2009
    ..Modulation of the TLR7 pathway in pDCs may therefore represent a new approach to reduce HIV-1-associated pathology...
  81. ncbi Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
    Paul J Pockros
    Division of Gastroenterology Hepatology, Scripps Clinic, La Jolla, CA, USA
    J Hepatol 47:174-82. 2007
    ..To explore safety, pharmacokinetics, and pharmacodynamics of oral administration of resiquimod, a Toll-like receptor 7 and 8 agonist that induces endogenous interferon-alpha, in subjects with chronic hepatitis C virus infection...
  82. pmc Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
    J M McNally
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Ave. N, Worcester, MA 01655, USA
    J Virol 75:5965-76. 2001
    ..Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections...
  83. ncbi The sensitivity of renal cell carcinoma cells to interferon alpha correlates with p53-induction and involves Bax
    S Wittnebel
    INSERM Unité 487, Cytokines et Immunologie des Tumeurs Humaines, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex
    Eur Cytokine Netw 16:123-7. 2005
    b>Interferon alpha (IFN-alpha) is an approved treatment in metastatic renal cell carcinoma (RCC)...
  84. ncbi Treatment of acute hepatitis C: the success of monotherapy with (pegylated) interferon alpha
    Johannes Wiegand
    Department of Internal Medicine, Medical Clinic and Polyclinic II, University of Leipzig, Leipzig, Germany
    J Antimicrob Chemother 62:860-5. 2008
    ..The present article summarizes the successful invention of immediate and delayed strategies in acute hepatitis C monoinfection, critically discusses potential limitations and illustrates the therapeutic challenges of the near future...
  85. pmc High rates of durable response are achieved with imatinib after treatment with interferon alpha plus cytarabine: results from the International Randomized Study of Interferon and STI571 (IRIS) trial
    Francois Guilhot
    Department of Oncology Hematology and Cell Therapy, CIC 802 INSERM, CHU de Poitiers, Poitiers, France
    Haematologica 94:1669-75. 2009
    ..The largest randomized clinical trial of imatinib was the multinational IRIS trial in which 1106 patients were randomized to receive either imatinib 400 mg/day or a standard regimen of interferon-alpha plus cytarabine...
  86. pmc Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis
    A Meager
    Division of Immunobiology, The National Institute for Biological Standards and Control, South Mimms, Herts, UK
    Clin Exp Immunol 132:128-36. 2003
    ..These findings must hold valuable clues to autoimmunizing mechanisms in paraneoplastic autoimmunity...
  87. pmc A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha
    H M Horton
    Vical, Inc, 9373 Towne Centre Drive, Suite 100, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:1553-8. 1999
    A cancer treatment is described in which i.m. injection of plasmid DNA (pDNA) encoding murine interferon alpha (mIFN-alpha) leads to potent antitumor effects on primary and metastatic tumors in mice. Mice bearing s.c...
  88. pmc Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    Lynda Bennett
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 197:711-23. 2003
    ..Therefore, while the IFN signature confirms the central role of this cytokine in SLE, microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis...
  89. pmc Interferon-alpha disables dendritic cell precursors: dendritic cells derived from interferon-alpha-treated monocytes are defective in maturation and T-cell stimulation
    Marc Dauer
    Section of Gastroenterology, Medizinische Klinik Innenstadt, University of Munich, Munich, Germany
    Immunology 110:38-47. 2003
    ....
  90. ncbi Immediate protection of swine from foot-and-mouth disease: a combination of adenoviruses expressing interferon alpha and a foot-and-mouth disease virus subunit vaccine
    Mauro P Moraes
    Plum Island Animal Disease Center, US Department of Agriculture USDA, Agricultural Research Service ARS, P O Box 848, North Atlantic Area NAA, Greenport, NY 11944 0484, USA
    Vaccine 22:268-79. 2003
    ..that swine inoculated with recombinant, replication-defective human adenovirus type 5 containing the porcine interferon alpha gene (Ad5-pIFNalpha) are completely protected when challenged 1 day later with virulent foot-and-mouth ..
  91. ncbi The phenomenology and treatment of interferon-induced depression
    Jennifer M Loftis
    Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR, USA
    J Affect Disord 82:175-90. 2004
    ..Screening and monitoring, ideally using symptom rating scales for depression, and early antidepressant treatment intervention appear necessary to optimize IFN therapy for the majority of patients...
  92. ncbi Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    Eur J Immunol 37:3582-6. 2007
    ..These data demonstrate that in addition to its ability to block IFN-alpha, IRS 954 can reduce symptoms in a lupus model and thus represents a promising therapeutic agent for the treatment of SLE...
  93. ncbi Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis
    Emmalene J Bartlett
    Division of Health Sciences, Western Australian Biomedical Research Institute, Murdoch University, WA 6150, Australia
    Immunol Cell Biol 82:119-26. 2004
    ..Thus, treatment with IFN-beta administered prophylactically to high-risk patients in acquiring CMV infection may reduce the development of chronic autoimmune myocarditis...
  94. ncbi Cancer immunotherapy: the interferon-alpha experience
    John Kirkwood
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 2582, USA
    Semin Oncol 29:18-26. 2002
    ....
  95. ncbi Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection
    Bobbie Ann Austin
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Biomedical Sciences Building, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Immunol 175:1100-6. 2005
    ....
  96. ncbi Immunopotentiation of a foot-and-mouth disease virus subunit vaccine by interferon alpha
    Sonia de Avila Botton
    Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U S Department of Agriculture, P O Box 848, Greenport, NY 11944, United States
    Vaccine 24:3446-56. 2006
    The adjuvant effect of porcine interferon alpha (pIFN-alpha) was examined in swine vaccinated with a replication-defective adenovirus containing foot-and-mouth disease virus (FMDV) A24 capsid and 3C proteinase coding regions (Ad5-A24)...
  97. ncbi Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells
    Kazuyuki Ohata
    The First Department of Internal Medicine, Nagasaki University, 1 7 1 Sakamoto, 852 8501 Nagasaki, Japan
    FEBS Lett 553:304-8. 2003
    ..These results suggest that IFN-alpha may have a function to block the NF-kappaB activating pathway triggered by HBx in HBV hepatocytes...
  98. ncbi TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    Roberto Baccala
    The Scripps Research Institute, Department of Immunology, La Jolla, California 93037, USA
    Nat Med 13:543-51. 2007
    ....
  99. ncbi [Effectiveness and complications of combination therapy with interferon alpha and ribavirin in patients with chronic hepatitis C]
    Sang Youn Hwang
    Department of Internal Medicine, Pusan National University College of Medicine, 10 Ami dong 1 ga, Seo Gu, Busan, Korea
    Korean J Gastroenterol 49:166-72. 2007
    The effectiveness of combination therapy with conventional or pegylated interferon alpha and ribavirin in patients with chronic hepatitis C is well understood...
  100. pmc Human T-cell leukemia virus type 1 blunts signaling by interferon alpha
    Xuan Feng
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Virology 374:210-6. 2008
    ....
  101. ncbi Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells
    Gunther Hartmann
    Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig Maximilians University of Munich, Germany
    Eur J Immunol 33:1633-41. 2003
    ..CpG-C may allow for improved therapeutic immuno-modulation in vivo...

Research Grants68

  1. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..The investigators have preliminary evidence to demonstrate that acrolein, at nontoxic concentrations, significantly down-regulates IFN1 signaling and antiviral/anti-HCV gene expression. ..
  2. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  3. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..Therefore, we propose inhibiting CXCL13 using a human monoclonal antibody. The primary clinical outcome will again be adverse events. The primary mechanistic outcome will be changes in peripheral blood memory B cells. ..
  4. Intracellular immunization strategy in inhibit HCV related liver cancer
    Srikanta Dash; Fiscal Year: 2010
    ..We have shown that HCV replication in the subcutaneous tumors in the SCID mice is inhibited by interferon alpha. This provides a reliable animal model for testing intracellular immunization for HCV using the antibody...
  5. Naltrexone and AIDS progression
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..If LDN can reduce the progression of AIDS in the highly translational SIV-infected macaque model, the research could validate a low cost and safe intervention to curtail disease progression with little or no side effects. ..
  6. Progesterone &Estrogen Differentially Regulate DC Function in Lupus Autoimmunity
    Grant Hughes; Fiscal Year: 2012
    ..Moreover, they will identify novel therapeutic approaches for treatment and prevention of disease development in SLE patients. ..
  7. Anti HCV Protease Activities of Metalloporphyrins
    Warren N Schmidt; Fiscal Year: 2013
    ..The immediate goals of this application are to characterize the antiviral actions of MPs as well as establish the feasibility of these compounds for therapeutic use in humans. ..
  8. Interferon Alpha: The Link Between Lupus and Endothelial Dysfunction
    JOY N BUIE; Fiscal Year: 2013
    ..Finally, the student will submit work for publication in peer-reviewed journals. ..
  9. Predictive Markers in Metastatic Renal Cancer
    Phillip G Febbo; Fiscal Year: 2012
    ..The CALGB has completed an Intergroup Phase III trial of interferon alpha (IFNA) plus bevacizumab versus IFNA alone in 732 patients with metastatic renal cell carcinoma (CALGB 90206), ..
  10. Genetic Regulation of Indoleamine-2,3-dioxygenase and Psychiatric Complications o
    Gregory F Oxenkrug; Fiscal Year: 2010
    ..HEALTH RELEVANCE: The proposed study aims to investigate whether analysis of cytokine gene polymorphisms might help to identify hepatitis C patients with high risk of developing psychiatric complications in response to IFN-alpha therapy ..
  11. Regulation of Type I IFNs in Tolerance and Autoimmunity
    Stefania Gallucci; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT: Interferon alpha (IFN-a) is a pivotal player in the regulation of the innate and the adaptive immune responses, primarily through the activation of dendritic cells (DCs)...
  12. Backbone Modified Peptide-nucleic Acids as Antiviral Agents Against Hepatitis C
    MIHAELA R MIHAILESCU; Fiscal Year: 2012
    ....
  13. Slit2N for the Treatment of Viral Hemorrhagic Fever
    ALAN L MUELLER; Fiscal Year: 2012
    ..With this information, we would then expect to meet with the FDA in a pre-IND meeting to discuss the final preclinical requirements and future clinical path. ..
  14. Interferon Alpha as a Tool for Gene Discovery in Human Lupus
    Timothy B Niewold; Fiscal Year: 2013
    ..Many lines of evidence support the idea that increased interferon alpha (IFNa) pathway signaling is causal in human lupus...
  15. Vulnerability to Major Depression and the Role of Sleep with Interferon-Alpha
    Francis E Lotrich; Fiscal Year: 2013
    ..This may be a common pathway for genes, stress, and inflammation to influence risk for depression. ..
  16. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..b>Interferon alpha-2b (IFN) promotes micrometastatic melanoma apoptosis by boosting intrinsic hepatic NK cells...
  17. Role of HOS in cell transformation and apoptosis
    Serge Y Fuchs; Fiscal Year: 2013
    ..Unfortunately, the efficacy of adjuvant therapy with recombinant interferon alpha (IFN1) is limited by the development of strategies that allow the tumor to evade the anti- proliferative and ..
  18. Inhibitors of Toll-like receptors 7 & 9 for treatment of skin inflammation
    FRANCK BARRAT; Fiscal Year: 2010
    ..We propose to develop a novel drug that inhibits Interferon-alpha, a key factor in the disease as a therapy for cutaneous lupus and related autoimmune diseases in the skin. ..
  19. Post-transcriptional regulation of the Dendritic Cell transcriptome
    Miriam Merad; Fiscal Year: 2013
    ..DC (pDC), which help to establish an antiviral state through the rapid secretion of high amounts of interferon alpha. While we now appreciate that DCs are a heterogeneous population, little is known about the mechanisms that ..
  20. Expression profiling of renal cell carcinoma utilizing tissue from CALGB 90206
    Hyung L Kim; Fiscal Year: 2013
    ..abstract_text> ..
  21. Regulation of Lymphocyte Trafficking by S1P1 and CD69
    Mehrdad Matloubian; Fiscal Year: 2012
    ..A variety of cytokines, including interferon alpha/beta (IFN), up-regulate expression of the transmembrane C-type lectin, CD69...
  22. Center for the Study of Innate Immunity to HCV Infection
    Michael J Gale; Fiscal Year: 2013
    ..Our studies are linked with the U19 Clinical Core, and Projects 2 and 3 to feature translational approaches aimed at defining the virus-host interface that controls hepatic innate immunity and HCV infection. ..
  23. Hepatitis C Virus and Hepatocellular Carcinoma
    Srikanta Dash; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interferon alpha (IFN-[unreadable]) along with ribavirin is the standard treatment for patients with chronic HCV infection but this therapy is unable to clear the virus in the majority of patients...
  24. Interferon Alpha Regulation of Murine Gammaherpesvirus Latency
    Erik S Barton; Fiscal Year: 2013
    ....
  25. Human Host Responses to Respiratory Syncytial Virus Infection
    NATALIE THORNBURG; Fiscal Year: 2010
    ..neonatal innate responses are immature and exhibit a Th2 biased cytokine response, impaired production of interferon alpha (IFNa), and decreased expression of Toll like receptors (TLRs)...
  26. Cutaneous Hemangiomas and Signal Transduction
    Jack L Arbiser; Fiscal Year: 2012
    ....
  27. Interferon Responses in Myeloid Leukemia
    Serge Y Fuchs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Imatinib mesylate (IM, also termed Gleevec) has replaced interferon alpha (IFNa) as the standard of care for patients with newly diagnosed chronic myeloid leukemia (CML) due to higher response ..
  28. An Exercise Intervention to Prevent Interferon-Induced Depression in Hepatitis C
    Chad D Rethorst; Fiscal Year: 2013
    ..The R01 will propose an RCT sufficiently powered to examine the efficacy of an exercise intervention in the prevention of IFN- [unreadable] -induced depression. ..
  29. Hepatitis C Virus Quasispecies in the Resistance to Antiviral Therapy
    Xiaofeng Fan; Fiscal Year: 2012
    ..We will examine viral determinants responsible for the treatment resistance through the application of novel technology. This may help to design more effective antiviral therapy to chronic HCV infection. ..
  30. Predicting Systemic Autoimmunity through Follow-up of Blood Relatives
    Judith A James; Fiscal Year: 2010
    ..Biospecimens and associated clinical data will be biobanked to test future alternate hypotheses. ..
  31. Structure-function determination of the Hepatitis C Virus negative RNA strand???s
    EDWARD ANHOA PHAM; Fiscal Year: 2013
    ....
  32. Genetic Regulation of interferon Alpha in Human Lupus
    Timothy B Niewold; Fiscal Year: 2013
    b>Interferon alpha (IFN-a) is a cytokine which is critically important to the pathogenesis of systemic lupus erythematosus (SLE)...
  33. Innate cytokine responses that regulate autoimmunity
    Harvey Cantor; Fiscal Year: 2012
    ..in plasmacytoid dendritic cells is essential for production of this cell's signature cytokine- interferon alpha. We have recently discovered that robust Th17 responses depend on the ability of a newly-defined ..
  34. Transcriptome association with inflammation-related major depression
    Francis E Lotrich; Fiscal Year: 2013
    ..The data generated by this 2-year study will guide our systematic next steps, which includes a more targeted and statistically powered investigation of the micro-array-identified pathways. ..
  35. Development of a novel drug candidate that inhibits hepatitis B virus covalently
    Haitao Guo; Fiscal Year: 2013
    ..Our research is thus highly related to the public health interest. The accomplishment of proposed research will ultimately lead to the better therapeutic for the management of hepatitis B disease. ..
  36. Phase 1 Study of Resiquimod Gel Therapy for Cutaneous T-Cell Lymphoma
    Alain H Rook; Fiscal Year: 2013
    ..marked deficiencies in the ability of these cells to produce cytokines, including interleukin-12 (I-12) and interferon alpha (IFN alpha), which are critical for antitumor immunity...
  37. Hepatitis C antivirals: Mechanism of action, combination efficacy and resistance
    Charles M Rice; Fiscal Year: 2013
    ..These studies will deepen our understanding of key biological processes involved in viral replication and provide new insights into DAA mechanisms of action that will be translatable to clinical studies. ..
  38. Novel Assay for Small Molecule Inhibitors of core-NS5A Interaction
    Arthur Donny Strosberg; Fiscal Year: 2011
    ..No vaccine has been developed so far, and the only treatment available today is a combination of pegylated interferon alpha and ribavirin...
  39. Indoleamine 23-Dioxygnease in Intestinal Inflammation
    William F Stenson; Fiscal Year: 2010
    ..of IDO using immunohistochemistry and flow cytometric cell sorting and definition of the roles of interferon alpha (IFNalpha) and interferon gamma (INFgamma) as mediators of IDO induction...
  40. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007
    ..This will be based on the hypothesis that EEEV possesses mechanism(s) to antagonize the interferon alpha/beta (IFN-a/b) response elicited by infected dendritic cells (DCs) which can be disabled to attenuate the ..
  41. Hepatitis C virus E2 glycoprotein
    Mansun Law; Fiscal Year: 2010
    ....
  42. The function and regulation of histocompatibility antigen 60 in cancer
    Jack D Bui; Fiscal Year: 2012
    ..This grant proposes to understand the function and regulation of the NKG2D ligand H60. An understanding of how H60 is placed on the tumor cell surface can help to enhance the immune-mediated detection and destruction of cancer. ..
  43. Development of an interferon-alpha-veltuzumab conjugate for CD20-targeted therapy
    Edmund A Rossi; Fiscal Year: 2011
    ..The lessons learned from this project may eventually lead to the development of additional MAb-IFNa for therapy of a variety of hematopoeitic and solid tumors. ..
  44. NK Cell Activation and Function in HIV-1 Exposed Uninfected IV Drug Users
    David W Speicher; Fiscal Year: 2013
    ....
  45. IL-28B genotype and HCV treatment clearance
    Srikanta Dash; Fiscal Year: 2013
    ..has been improved recently by the use of the protease inhibitor (telaprevir or boceprevir) along with interferon alpha (IFN-[unreadable]) and ribavirin...
  46. HIV Dysregulation of Human Plasmacytoid Dendritic Cells
    MEAGAN O'BRIEN; Fiscal Year: 2013
    ..We propose to define mechanisms by which HIV dysregulates the innate immune system, which will guide new strategies to maximize adaptive immune responses and limit immune activation. ..
  47. Inhibition of Hepatitis C Virus Infection by Interferon-induced Transmembrane Pro
    Courtney Wilkins; Fiscal Year: 2013
    ..The current treatment for HCV consists of pegylated interferon alpha (IFN-a) with ribavirin, yet this treatment is only effective in about half of all patients...
  48. TRAIL Mediated Apoptosis in Renal Cell Carcinoma
    Peter Clark; Fiscal Year: 2009
    ..carcinoma (RCC) is a deadly, chemotherapy resistant disease usually treated with biologic therapy such as interferon alpha (IFNa). New forms of therapy for advanced RCC are needed...
  49. A platform for image-guided, magneto-acoustic gene therapy of pancreatic cancer
    Beata Chertok; Fiscal Year: 2012
    ..the system will be further tested for therapeutic efficacy in a mouse model of human pancreatic cancer using interferon alpha plasmid DNA as a model gene therapeutic...
  50. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2003
    ..These studies will define the role of P450s in the alcohol enhancement of HCV liver injury and might suggest P450 inhibitors as therapies for HCV infected individuals even if they continue to drink alcohol. ..
  51. Quantitative and Spatial Optimization for Designing Cancer Therapeutics
    AVRAM LEV ROBINSON-MOSHER; Fiscal Year: 2013
    ..18 mouse monoclonal antibody. I intend to target a therapeutic agent, the naturally occurring protein interferon alpha 2a (IFN), to GD2-expressing cells using the chimeric activator approach pioneered by the lab of Professor ..
  52. Interferon-gamma To Treat Chronic HCV Infection
    Andrew Muir; Fiscal Year: 2002
    ..Secondary endpoints include the biochemical response, inflammatory and regulatory cytokine levels, and quality of life during treatment. ..
  53. Cell-Specific Programs of Host Defense Against West Nile Virus
    Michael J Gale; Fiscal Year: 2010
    ..of host cell pathogen recognition receptor (PRR) signaling programs of innate immunity that trigger interferon alpha/beta expression and that activate interferon regulatory factors (IRFs) to induce antiviral response genes ..
  54. RANDOMIZED ADJUVANT THERAPY OF HEAD AND NECK CANCER
    Dong Shin; Fiscal Year: 2001
    ....
  55. ZIDOVUDINE METABOLISM: REBRETRON TREATED HUMAN PATIENTS
    Jose Rodriguez; Fiscal Year: 2003
    ..The central hypothesis to be tested is that REBETRON (ribavirin + interferon alpha) will antagonize in vivo with ZDV, diminishing the formation of ZDV intracellular metabolites (ZDV-MP and ZDV-..
  56. Validation of genomic targets in melanoma
    Mohammed Kashani-Sabet; Fiscal Year: 2013
    ..analysis in a prospective cohort, the randomized intergroup trial of adjuvant therapy with high-dose interferon alpha (Eastern Cooperative Group trial E1690)...
  57. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2007
    ..Information gained from the proposed experiments will have implications for the treatment of HIV infected patients with immunomodulatory therapies, such as IFN-alpha. ..
  58. NOVEL TREATMENT OF REFRACTORY GI MALIGNANCIES
    Scott Wadler; Fiscal Year: 1999
    ....
  59. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2009
    ..between early virological responders and non-responders will lead to a better understanding of host pathways involved in the suppression of hepatitis C virus replication and the induction of a sustained virological response to therapy ..
  60. ROLE OF A-INTERFERON RECEPTOR IN HUMAN IMMUNOREGULATION
    Sharon Evans; Fiscal Year: 1992
    ..Thus, studies investigating the basic mechanisms of IFN involved in immunoregulation should clearly provide insight into the interaction of IFN with malignant cells from both IFN-sensitive and resistant patients...
  61. INTERFERON RECEPTORS IN ORGAN TRANSPLANTATION
    Verna Gibbs; Fiscal Year: 1999
    ..The information generated from these studies may provide a rational basis for the development of agonists and antagonists which may be clinically useful in preventing acute graft rejection and chronic graft failure. ..
  62. Expression of Human Therapeutic Proteins in Transgenic Tobacco Chloroplasts
    Henry Daniell; Fiscal Year: 2010
    ..Transgenic plants expressing vaccine antigens (e.g.-anthrax plague) and human blood proteins (e.g.- interferon alpha 2b, human serum albumin) have been grown in the field and their functionality has been determined by in vitro ..
  63. ORAL IFN ALPHA--BIOLOGICAL EFFECTS IN MULTIPLE SCLEROSIS
    Staley Brod; Fiscal Year: 1999
    ..Ingested IFN-alpha may provide superior efficacy and safety in comparison to parenteral administered Type-1 IFNs in RR-MS and other autoimmune diseases. ..
  64. DNA DAMAGE AS PREDICTOR OF CLINICAL RESPONSE IN MELANOMA
    Francis Ali Osman; Fiscal Year: 1999
    ..He will also facilitate the rational extension of biochemotherapy regimens to other more common solid tumors which traditionally are not treated with this modality. ..
  65. Role of liver cytokines in hepatitis C viral infection
    Chen Liu; Fiscal Year: 2006
    ..antiviral cytokines modulate viral RNA replication and the predictive role of these cytokines in response to interferon alpha treatment...
  66. MASSAGE THERAPY FOR PATIENTS WITH HIV-1
    Thomas Birk; Fiscal Year: 1993
    ..one antiretroviral medication will improve the immune system as measured by CD4, natural killer cells and interferon alpha levels in persons with advanced HIV...
  67. L-NUCLEOSIDES AS ANTI-HBV AGENTS
    Kyoichi Watanabe; Fiscal Year: 2000
    ..This number is growing, which indicates that more effective treatments are needed. Worldwide millions of chronically infected patients need be treated. ..
  68. Novel-Non-Viral Delivery of IFN Gene to Cancer Cells
    NATHALIE BELLOCQ; Fiscal Year: 2004
    ..In future studies (phase II SBIR), we will conduct pre-clinical development of the delivery system so that it can be tested in clinical trials as a more efficient means to administer IFNa to patients. ..