interferon type ii

Summary

Summary: The major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon (INTERFERON TYPE I) and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease.

Top Publications

  1. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  2. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
  3. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
  4. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
  5. ncbi Mechanisms of type-I- and type-II-interferon-mediated signalling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 710 North Fairbanks Court, Olson 8250, Chicago, Illinois 60611, USA
    Nat Rev Immunol 5:375-86. 2005
  6. ncbi Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    Michael R Betts
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    J Immunol Methods 281:65-78. 2003
  7. ncbi Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
  8. ncbi Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
    Nat Immunol 7:929-36. 2006
  9. ncbi CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
  10. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006

Research Grants

  1. MOLECULAR MECHANISM OF TAT INDUCED ANGIOGENESIS
    Cindy Morris; Fiscal Year: 2002
  2. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
  3. Study of gamma interferon agonists/mimetics
    Howard M Johnson; Fiscal Year: 2012
  4. Hyperphenylalaninemia in cerebral malaria
    DONALD LEE GRANGER; Fiscal Year: 2010
  5. Modulation of Pulmonary Defenses in Pathobiology of Chronic Infections
    Michal A Olszewski; Fiscal Year: 2013
  6. MHC Class II Antigen Processing and Immune Recognition of Melanoma
    KAREN TARASZKA HASTINGS; Fiscal Year: 2011
  7. New Fluorescent Caspase Detection Probes to Label Apoptotic Tumor Cells In Vivo
    Brian Lee; Fiscal Year: 2009
  8. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2013
  9. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2012
  10. CD40 and TLR Agonists in Melanoma
    Jeffrey S Weber; Fiscal Year: 2010

Detail Information

Publications281 found, 100 shown here

  1. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  2. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  3. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
    ..Thus, T-bet is induced by IFN-gamma and STAT1 signaling during T cell activation. In addition, T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2...
  4. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
    ..These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole...
  5. ncbi Mechanisms of type-I- and type-II-interferon-mediated signalling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 710 North Fairbanks Court, Olson 8250, Chicago, Illinois 60611, USA
    Nat Rev Immunol 5:375-86. 2005
    ..It is anticipated that an increased understanding of the contributions of these recently identified pathways will advance our current thinking about how interferons work...
  6. ncbi Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    Michael R Betts
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    J Immunol Methods 281:65-78. 2003
    ....
  7. ncbi Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
    ..Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses...
  8. ncbi Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
    Nat Immunol 7:929-36. 2006
    ..Finally, IL-27 suppressed IL-6-mediated T cell proliferation. These data provide a mechanistic explanation for the IL-27-mediated immune suppression noted in several in vivo models of inflammation...
  9. ncbi CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    ..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...
  10. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
  11. ncbi The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
    ..These results also suggest secondary lymphoid organs as a possible site of NK cell differentiation and self-tolerance acquisition...
  12. pmc Serial testing of health care workers for tuberculosis using interferon-gamma assay
    Madhukar Pai
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA
    Am J Respir Crit Care Med 174:349-55. 2006
    ..Although interferon-gamma (IFN-gamma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing performance is unknown...
  13. pmc IL-18-induced CD83+CCR7+ NK helper cells
    Robbie B Mailliard
    Department of Surgery, University of Pittsburgh, PA, USA
    J Exp Med 202:941-53. 2005
    ..The current data demonstrate independent regulation of the "helper" versus "effector" pathways of NK cell differentiation and novel mechanisms of immunoregulation by IL-18 and PGE2...
  14. ncbi Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    Heiner Wedemeyer
    Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3447-58. 2002
    ..Thus, the defective functions of HCV-specific CD8+ T cells might contribute to viral persistence in chronically infected patients, and knowledge on their reversibility may facilitate the development of immunotherapeutic vaccines...
  15. ncbi The roles of IFN gamma in protection against tumor development and cancer immunoediting
    Hiroaki Ikeda
    Department of Pathology and Immunology, Center for Immunology, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cytokine Growth Factor Rev 13:95-109. 2002
    ....
  16. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
    ....
  17. ncbi Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    Udaya K Liyanage
    Alvin J Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:2756-61. 2002
    ..These T(reg) may mitigate the immune response against cancer, and may partly explain the poor immune response against tumor Ags...
  18. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  19. ncbi New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:413-22. 2006
    ..The review concludes by highlighting areas where evidence is lacking, and provides an agenda for future research. Active TB and drug resistance are discussed in Part II; 423-432 of this issue...
  20. ncbi Alternative activation of STAT1 and STAT3 in response to interferon-gamma
    Yulan Qing
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:41679-85. 2004
    ....
  21. ncbi A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Christine Bourgeois
    INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
    Science 297:2060-3. 2002
    ..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
  22. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    ....
  23. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ....
  24. pmc The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    Mohammed Javeed I Ansari
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 198:63-9. 2003
    ....
  25. ncbi SOCS3 regulates the plasticity of gp130 signaling
    Roland Lang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:546-50. 2003
    ..Thus, SOCS3 functions to control the quality of the response to IL-6 and prevents the activation of an IFN-induced program of gene expression...
  26. ncbi Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma
    Yasmina Laouar
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 6:600-7. 2005
    ....
  27. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  28. ncbi The immunobiology of cancer immunosurveillance and immunoediting
    Gavin P Dunn
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, Missouri 63110, USA
    Immunity 21:137-48. 2004
    ..The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers...
  29. pmc Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells
    Torsten Bunde
    Institut fur Medizinische Immunologie, Charite, Universitatsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany
    J Exp Med 201:1031-6. 2005
    ..In conclusion, high frequencies of IE-1 but not pp65-specific CD8 T cells correlate with protection from CMV disease. These results have important implications for monitoring T cell responses, adoptive cell therapy, and vaccine design...
  30. ncbi Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine and School of Public Health, Columbus, Ohio 43210, USA
    Immunity 24:575-90. 2006
    ..Collectively, our data suggest that pro- and antiinflammatory cytokine signaling reciprocally antagonize each other in an effort to prevail in the regulation of NK cell IFN-gamma production...
  31. pmc Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon
    Fernando Rodriguez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4251-9. 2002
    ....
  32. ncbi The Jak-STAT pathway stimulated by interferon gamma
    Curt M Horvath
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, IL 60208, USA
    Sci STKE 2004:tr8. 2004
    ..The animation shows binding of IFN-gamma and dimerization of the receptors, activation of Jak1 and Jak2, and phosphorylation of STAT1 leading to dimerization, translocation to the nucleus, and stimulation of target gene transcription...
  33. pmc Gammadelta T cells promote a Th1 response during coxsackievirus B3 infection in vivo: role of Fas and Fas ligand
    Sally Huber
    Department of Pathology, College of Medicine, The University of Vermont, Burlington, VT 05405, USA
    J Virol 76:6487-94. 2002
    ..These results demonstrate that Fas/FasL interactions conferred by gammadelta T cells on lymphocyte subpopulations may regulate the cytokine response to CVB3 infection and pathogenicity...
  34. pmc Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice
    Fanny Tzelepis
    CINTERGEN, UNIFESP Escola Paulista de Medicina, Rua Mirassol, 207, Sao Paulo SP, Brazil, 04044 010
    Infect Immun 74:2477-81. 2006
    ..In contrast, in vaccinated mice, the swift CD8+-T-cell response helps host survival after challenge...
  35. pmc Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
    Marcel Asper
    Department of Virology, Bernhard Nocht Institute of Tropical Medicine, 20359 Hamburg, Germany
    J Virol 78:3162-9. 2004
    ..Both cytokines inhibit replication which is relevant for the design of antiviral strategies against Lassa fever with the aim of enhancing the IFN response...
  36. ncbi Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity
    Anna K Palucka
    Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 29:545-57. 2006
    ..Thus, the present results justify the design of larger follow-up studies to assess the clinical response to DC vaccines loaded with killed allogeneic tumor cells in patients with metastatic melanoma...
  37. pmc Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    M M Addo
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School Fenway Community Health Center Lemuel Shattuck Hospital, Boston, Massachusetts 02129, USA
    J Virol 77:2081-92. 2003
    ....
  38. pmc Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    Craig A Murphy
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 198:1951-7. 2003
    ..The data presented here indicate that IL-23 is an essential promoter of end-stage joint autoimmune inflammation, whereas IL-12 paradoxically mediates protection from autoimmune inflammation...
  39. ncbi Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention
    Yona Kalechman
    C A I R Institute, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Immunol 169:384-92. 2002
    ....
  40. ncbi A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2
    Jay H Bream
    Lymphocyte and Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health NIH, Bethesda, Maryland 20892 1820, USA
    J Biol Chem 279:41249-57. 2004
    ..These data led us to conclude that this distal region serves as both a target of chromatin remodeling in the IFNG locus as well as an IL-2-induced transcriptional enhancer that binds Stat5 proteins...
  41. pmc Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production
    Petr Bocek
    Division of Allergy, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6610 Rockledge Dr, Rm 3060, Bethesda, MD 20892, USA
    J Exp Med 199:1619-30. 2004
    ..Thus, IFNgamma plays an unanticipated but substantial role in Th2 priming, although it is an important Th1 cytokine, and under certain circumstances a Th1 inducer...
  42. ncbi B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
    M G S Vieira
    Faculdade de Medicina, Universidade Federal da Bahias, Salvador, BA, Brasil
    Mem Inst Oswaldo Cruz 97:979-83. 2002
    ....
  43. ncbi HIV preferentially infects HIV-specific CD4+ T cells
    Daniel C Douek
    Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
    Nature 417:95-8. 2002
    ..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption...
  44. ncbi Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort
    Jeffrey J Post
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Infect Dis 189:1846-55. 2004
    ..These cases highlight the potential for cellular immune responses against HCV to facilitate viral clearance, responses that may model those required for effective HCV vaccination...
  45. pmc Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells
    Willem W Overwijk
    National Cancer Institute NCI, National Institute of Health, Bethesda, MD 20892 1502, USA
    J Exp Med 198:569-80. 2003
    ....
  46. pmc Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization
    Denise M Monack
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Exp Med 199:231-41. 2004
    ..Thus, interferon-gamma, which may affect the level of macrophage activation, plays an essential role in the control of the persistent S. typhimurium infection in mice...
  47. ncbi Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction
    Alan C Mullen
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Nat Immunol 3:652-8. 2002
    ..These findings suggest that heritable states of gene expression might be maintained by continued expression of the inducing factor or by a mechanism that confers a stable imprint of the induced state...
  48. pmc Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15011-6. 2003
    ..This phenomenon is not attributed to a direct HIV-1 infection of NK cells; thus, this study may provide insight into the mechanisms of impaired host defenses in HIV-1 viremic patients...
  49. pmc Analysis of the immune response to Mycobacterium avium subsp. paratuberculosis in experimentally infected calves
    Hye Cheong Koo
    Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Infect Immun 72:6870-83. 2004
    ..The studies clearly show multicolor FC offers a consistent reliable way to monitor the evolution and changes in the immune response to M. avium subsp. paratuberculosis that occur during disease progression...
  50. pmc Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection
    Jason K Whitmire
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 201:1053-9. 2005
    ..The stimulatory effect is abrogated in T cells lacking the IFNgamma receptor, indicating that the cytokine acts directly upon CD8(+) T cells to increase their abundance during acute viral infection...
  51. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  52. ncbi IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells
    Rosalba Salcedo
    Pediatric Oncology Branch, National Cancer Institute Center for Cancer Research, Frederick, MD 21702, USA
    J Immunol 173:7170-82. 2004
    ..Collectively, these studies suggest that IL-27 could be used therapeutically to potentiate the host antitumor immune response in patients with malignancy...
  53. ncbi Importance of CD8(+)Vbeta8(+) T cells in IFN-gamma-mediated prevention of toxoplasmic encephalitis in genetically resistant BALB/c mice
    Xisheng Wang
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Interferon Cytokine Res 25:338-44. 2005
    ....
  54. ncbi Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells
    Ellen N Kersh
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 176:4083-93. 2006
    ....
  55. ncbi Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
    Manfred Kopf
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nat Med 8:373-8. 2002
    ..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
  56. ncbi CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
    Nicola Dalbeth
    Division of Medicine, Imperial College London, Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Immunol 173:6418-26. 2004
    ..Such a positive feedback loop is likely to be important in the pathogenesis of chronic inflammatory conditions such as rheumatoid arthritis...
  57. pmc Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function
    Daniel B Stetson
    University of California San Francisco, Box 0654, C 443, 521 Parnassus Avenue, San Francisco, CA 94143, USA
    J Exp Med 198:1069-76. 2003
    ..Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes...
  58. ncbi Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis
    Hee Jin Cheong
    Section of Infectious Disease, Department of Internal Medicine, Korea University Medical College, Korea University Guro Hospital, 97 Guro Dong Gil, Guro Gu, Seoul 152 703, South Korea
    Vaccine 24:2417-22. 2006
    ..Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function...
  59. ncbi Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals
    Marcin Kortylewski
    Institut fur Biochemie, Aachen, Germany
    J Invest Dermatol 122:414-22. 2004
    ..Our results suggest the presence of additional signals emanating from the interferon-gamma receptor, which may counteract the anti-proliferative function of STAT1...
  60. ncbi Decreased production of interleukin-12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer
    Masahiko Shibata
    First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Clin Gastroenterol 34:416-20. 2002
    ..The authors' findings indicate that the induction of Th1 cells seems to be suppressed at a relatively early stage of disease, whereas that of Th2 cells seems to increase in the terminal stage...
  61. pmc Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain
    Jianping Wang
    The Scripps Research Institute, SP315, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Invest 112:535-43. 2003
    ..Moreover, a hitherto unknown role is indicated for the immune system in the pathogenesis of developmental disorders and tumorigenesis of the CNS via dysregulated Shh signaling mediated by IFN-gamma...
  62. ncbi Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae
    Tom H M Ottenhoff
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Genet 32:97-105. 2002
    ..Ten syndromes have thus far been identified. Recent insights in genetically controlled host defense and susceptibility to mycobacterial disease are discussed...
  63. ncbi The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
    ..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...
  64. pmc Reciprocal activating interaction between natural killer cells and dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
    J Exp Med 195:327-33. 2002
    ..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
  65. ncbi Distinct inflammatory mechanisms mediate early versus late colitis in mice
    David M Spencer
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    Gastroenterology 122:94-105. 2002
    ..We report a longitudinal study investigating changes in the mucosal immune response in an experimental model of colitis...
  66. ncbi Interferon-gamma: an overview of signals, mechanisms and functions
    Kate Schroder
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
    J Leukoc Biol 75:163-89. 2004
    ..In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-alpha, interleukin-4, type I IFNs, and lipopolysaccharide are discussed...
  67. ncbi Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    Khuong B Nguyen
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 297:2063-6. 2002
    ..Thus, type 1 IFNs, in addition to interleukin-12, provide pathways for innate regulation of adaptive immunity, and their immunoregulatory functions are controlled by modulating the activity of individual STATs...
  68. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
    ..These findings indicate that IL-10 production by CD4(+) T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens...
  69. pmc T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
    Anubhav N Mathur
    Department Microbiology and Immunology, Indiana University School of Medicine, 702 Barnhill Dr, RI 2600, Indianapolis, IN 46202, USA
    Blood 108:1595-601. 2006
    ..The transient nature of the Th1beta phenotype suggests that these cells are a component of type I immunity and that T-bet expression is a critical determinant of Th1 versus Th1beta cell fate...
  70. ncbi Rapid development of colitis in NSAID-treated IL-10-deficient mice
    Daniel J Berg
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Gastroenterology 123:1527-42. 2002
    ..Prostaglandins are lipid mediators that may be important mediators of intestinal inflammation. In this study we assessed the role of prostaglandins in the regulation of mucosal inflammation in the IL-10(-/-) mouse model of IBD...
  71. pmc Development and validation of a bovine macrophage specific cDNA microarray
    Kirsty Jensen
    Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh, EH25 9PS, UK
    BMC Genomics 7:224. 2006
    ..However, the microarray resources available to study these events in livestock animals are limited...
  72. ncbi HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nature 420:434-9. 2002
    ..The lack of cross-protective immunity for closely related HIV-1 strains, despite persistent recognition of multiple CD8 epitopes, has important implications for public health and vaccine development...
  73. ncbi Antiangiogenic and antitumor activities of IL-27
    Motomu Shimizu
    Medical R and D Center, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Bunkyo ku, Japan
    J Immunol 176:7317-24. 2006
    ..These results suggest that IL-27 possesses potent antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities...
  74. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  75. ncbi GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:415-28. 2003
    ..These findings reassert that Stat4 signaling is a central element of Th1/Th2 development...
  76. ncbi Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1230-7. 2003
    ..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
  77. pmc Use of recombinant ESAT-6:CFP-10 fusion protein for differentiation of infections of cattle by Mycobacterium bovis and by M. avium subsp. avium and M. avium subsp. paratuberculosis
    W R Waters
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, Iowa 50010 0070
    Clin Diagn Lab Immunol 11:729-35. 2004
    ..avium subsp. paratuberculosis, it appears that use of the rESAT-6:CFP-10 fusion protein will be useful for the detection of tuberculous cattle in herds with pre-existing sensitization to M. avium and/or M. avium subsp. paratuberculosis...
  78. pmc Low dose chronic Schistosoma mansoni infection increases susceptibility to Mycobacterium bovis BCG infection in mice
    D Elias
    Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 139:398-404. 2005
    ..This finding is potentially important in the control of TB in helminth endemic parts of the world...
  79. ncbi A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors
    Giuseppe Giaccone
    Department of Medical Oncology, Vrije Universiteit Medical Center, HV 1081 Amsterdam, The Netherlands
    Clin Cancer Res 8:3702-9. 2002
    ..We performed a dose escalation study of KRN7000 in advanced cancer patients...
  80. ncbi Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis
    Katalin A Wilkinson
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Infect Dis 40:184-7. 2005
    ..The recruitment of ESAT-6-specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis...
  81. ncbi Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
    David Vremec
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 109:1165-73. 2007
    ..However, IKDCs, which efficiently produced IFN-gamma and showed immediate cytotoxicity on NK target cells, did not produce IFN-alpha under these conditions...
  82. ncbi Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses
    Rika Draenert
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Immunol Methods 275:19-29. 2003
    ..We conclude that peptides ranging from 15 to 20 amino acids yield similar results in IFN-gamma-based Elispot and ICS assays, and that all are likely to underestimate the true breadth of responses to a given reference strain of virus...
  83. pmc T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy
    Alda Maria Da-Cruz
    Laboratory of Cellular and Humoral Immunology, Department of Immunology Protozoology, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    Clin Diagn Lab Immunol 9:251-6. 2002
    ....
  84. ncbi Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice
    Ziad Mallat
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 108:1232-7. 2003
    ....
  85. ncbi Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
    Junko Matsuzaki
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
    Cell Immunol 224:98-105. 2003
    ..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo...
  86. ncbi Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation
    Xiaoyu Hu
    Graduate Program in Immunology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Nat Immunol 3:859-66. 2002
    ..These results identify a mechanism that sensitizes macrophages to low concentrations of IFN-gamma and regulates IFN-gamma responses in acute and chronic inflammation...
  87. ncbi A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone
    Jon D Piganelli
    Department of Immunology, University of Colorado Health Sciences Center and Barbara Davis Center for Childhood Diabetes, Denver, Colorado, USA
    Diabetes 51:347-55. 2002
    ..Finally, this compound protected NIT-1 insulinoma cells from interleukin-1beta and alloxan cytotoxicity in vitro...
  88. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
    ..Moreover, development of spontaneous tumors in p53(+/-) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors...
  89. pmc Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide
    John Schmieg
    Dept of Medical and Molecular Parasitology, New York University School of Medicine, 341 E 25th St, New York, NY 10010 email
    J Exp Med 198:1631-41. 2003
    ..Overall, our results suggest that alpha-C-GalCer may one day be an excellent therapeutic option for diseases resolved by Th1-type responses...
  90. pmc Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines
    Gloria Gonzalez-Aseguinolaza
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
    J Exp Med 195:617-24. 2002
    ..As alpha-GalCer stimulates both human and murine NKT cells, these findings should contribute to the design of more effective vaccines against malaria and other intracellular pathogens, as well as tumors...
  91. pmc Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection
    Jianhong Cao
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:6867-78. 2003
    ..Many novel epitopes, particularly directed to Nef, Tat, and Env, and frequently with unique HLA restrictions, merit further consideration in vaccine design...
  92. ncbi Interferon-gamma induced medulloblastoma in the developing cerebellum
    Wensheng Lin
    Jack Miller Center for Peripheral Neuropathy, Department of Neurology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:10074-83. 2004
    ..Thus, IFN-gamma expression in the perinatal period can induce SHH expression and medulloblastoma in the cerebellum by a STAT1-dependent mechanism, and its continued presence appears to promote a host response to the tumor...
  93. ncbi The influence of remaining live BCG organisms in vaccinated mice on the maintenance of immunity to tuberculosis
    A W Olsen
    Department of Infectious Disease Immunology Statens Serum Institut Copenhagen, Denmark
    Scand J Immunol 60:273-7. 2004
    ..The implications for comparing BCG vaccination with experimental vaccines including non-replicating vaccines are discussed...
  94. pmc Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors
    Robert S Welner
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Blood 109:4825-931. 2007
    ..These observations suggest that IKDCs may arise from a unique differentiation pathway, and one that diverges early from those responsible for NK cells, pDCs, and T and B cells...
  95. ncbi Natural-killer cells and dendritic cells: "l'union fait la force"
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Marseille, France
    Blood 106:2252-8. 2005
    ..Thus, DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses...
  96. ncbi Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    Samuel J McConkey
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Nat Med 9:729-35. 2003
    ..Such heterologous prime-boost immunization approaches may provide a basis for preventative and therapeutic vaccination in humans...
  97. ncbi Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 172:4672-5. 2004
    ..major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced...
  98. ncbi IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    Mari Strengell
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Immunol 170:5464-9. 2003
    ..IL-18, however, activated the binding of NF-kappa B to the IFN-gamma promoter NF-kappa B site. Our results suggest that both IL-15 and IL-21 have an important role in activating the NK cell-associated innate immune response...
  99. ncbi Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
    Philippe Stock
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Nat Immunol 5:1149-56. 2004
    ..Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs...
  100. pmc Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells
    Michael J Eppihimer
    Discovery Research Respiratory Diseases, Wyeth Genetics Institute, Andover, MA 01810, USA
    Microcirculation 9:133-45. 2002
    ..To evaluate the expression and regulation of a novel B7-like protein, PD-L1, the ligand for the immunoinhibitory receptor PD-1 expressed on activated T-cells, on microvascular endothelial cells (ECs)..
  101. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
    ..It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR...

Research Grants63

  1. MOLECULAR MECHANISM OF TAT INDUCED ANGIOGENESIS
    Cindy Morris; Fiscal Year: 2002
    ....
  2. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
    ..Since the effect of GILT is not limited to the presentation of TRP1 or cutaneous autoantigens, modulation of GILT expression or activity may be a broadly applied therapeutic approach for autoimmune disease. ..
  3. Study of gamma interferon agonists/mimetics
    Howard M Johnson; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVENCE: Our interferon mimetic is a novel therapeutic for treating viral and other infectious diseases. The SOCS-1 antagonist should provide a new paradigm to boosting the immune system against infections and cancer. ..
  4. Hyperphenylalaninemia in cerebral malaria
    DONALD LEE GRANGER; Fiscal Year: 2010
    ..If the hypotheses are correct, it may be possible to alter CNS disease by administering precursors for BH4 and BAN. Thus the project may lead to rapid translation into trials for management of children with CM. ..
  5. Modulation of Pulmonary Defenses in Pathobiology of Chronic Infections
    Michal A Olszewski; Fiscal Year: 2013
    ..Our studies reveal how a major opportunistic fungal pathogen C. neoformans may exploit the loopholes in M signaling to establish intracellular parasitism and propose a treatment strategy to prevent its occurrence. ..
  6. MHC Class II Antigen Processing and Immune Recognition of Melanoma
    KAREN TARASZKA HASTINGS; Fiscal Year: 2011
    ..The long-term goal of these studies is to aid the development of effective immunotherapy for melanoma. ..
  7. New Fluorescent Caspase Detection Probes to Label Apoptotic Tumor Cells In Vivo
    Brian Lee; Fiscal Year: 2009
    ..Finally, it is hypothesized that these animal studies will provide a foundation for eventual use in human patients. ..
  8. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2013
    ..abstract_text> ..
  9. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2012
    ....
  10. CD40 and TLR Agonists in Melanoma
    Jeffrey S Weber; Fiscal Year: 2010
    ..The general health of all Americans would be improved if we could understand the mechanisms by which T cell immunity with high-avidity, long lasting anti-tumor effector cells were generated in cancer patients. ..
  11. Once Monthly Antiretroviral Nanoparticles for HIV-1 Treatment
    Christopher J Destache; Fiscal Year: 2011
    ..This will be the first step to determine the utility of AR NPs as a treatment option suitable for human use. ..
  12. UROTHELIAL CELL ACTIVATION IN INTERSTITIAL CYSTITIS
    Monica Liebert; Fiscal Year: 1993
    ....
  13. ACTIVE SPECIFIC IMMUNOTHERAPY IN MAN--A MURINE MODEL
    Barry Kahan; Fiscal Year: 1992
    ..The proposed studies thus proffer a molecular approach to dissect potential antigens augmenting host resistance for active specific immunotherapy...
  14. PROTEINS BINDING TO THE HUMAN GAMMA INTERFERON PROMOTER
    Don Diamond; Fiscal Year: 1992
    ..The discovery that HTLV gene products modify the action of Cs A on the immune system has potential implication for patients in need of immunosuppressive therapy (transplantation) who have attendant retroviral- associated (HTLV) disease...
  15. IMMUNOREGULATORY EFFECTS OF THE INTERFERONS
    Howard Ozer; Fiscal Year: 1992
    ..These studies will clarify the biology of the interferon system and may permit its clinical use in combination with other lymphokines or possibly identify alternative therapeutic strategies in the treatment of human malignancy...
  16. LPS-MONOCYTE INTERACTIONS IN PERIODONTAL DISEASE
    Frank Nichols; Fiscal Year: 1990
    ..We hope to establish that LPS-mediated PGE2 release from monocytes is an inherent response which is not affected by periodontal therapy...
  17. IMMUNOBIOLOGY OF B CELL DIFFERENTIATION
    Kenneth Dorshkind; Fiscal Year: 1991
    ..The data from these studies will provide a knowledge of the basic biology of normal B cell differentiation and contribute to understanding pathological B cell development...
  18. INTERFERON RECEPTORS IN ORGAN TRANSPLANTATION
    Verna Gibbs; Fiscal Year: 1999
    ..The information generated from these studies may provide a rational basis for the development of agonists and antagonists which may be clinically useful in preventing acute graft rejection and chronic graft failure. ..
  19. IMMUNE RESPONSE DURING ENTERIC INFLAMMATORY DISEASE
    Michael Wannemuehler; Fiscal Year: 1993
    ....
  20. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003
    ..The resulting findings will be relevant to development of vaccines for prevention of mother-to-child transmission of HIV-1. ..
  21. IMMUNOREGULATION OF ANTILISTERIAL IMMUNITY
    David Hinrichs; Fiscal Year: 2000
    ....
  22. IGE AND IGA IN HUMAN PHAGOCYTE FUNCTION
    LILIAN SHEN; Fiscal Year: 1990
    ..Cells expressing various levels of Fc receptors after the procedures outlined above will be tested for ability to perform IgE, IgA and IgG mediated phagocytosis, ADCC, and lysosmal enzyme and leukotriene secretion...
  23. Hyperphenylalaninemia in cerebral malaria
    DONALD GRANGER; Fiscal Year: 2006
    ..If the hypotheses are correct, it may be possible to alter CNS disease by administering precursors for BH4 and BAN. Thus the project may lead to rapid translation into trials for management of children with CM. ..
  24. Human Tryptophanyl-tRNA Synthetase-A Functional Analysis
    Jerry Johnson; Fiscal Year: 2006
    ..Results from these experiments will determine how the kinase activities are regulated, what other proteins are modified, and what structural features of the enzyme are responsible for these properties. ..
  25. SUPPRESSION OF B-LYMPHOMAS VIA INDUCTION OF INTERFERONS
    Andrei Thomas Tikhonenko; Fiscal Year: 2003
    ..This anticipated result will establish that STAg or similar protozoan or bacterial antigens could be developed into new therapeutic modalities for AIDS-related Burkitt lymphoma. ..
  26. STEM CELLS AND ACCESSORY CELLS IN PERIPHERAL BLOOD
    Beverly Torok Storb; Fiscal Year: 2003
    ..Our final goal is to use the G-PBMC product to establish a non-toxic conditioning regimen to achieve stable mixed chimerism in haploidentical donor/recipient pairs. ..
  27. SECRETORY IMMUNE SYSTEM AND THE SKIN
    J Huff; Fiscal Year: 1990
    ..Synthesis of SC by HK from patients with these disease will be studied in vitro, and the interaction of the HK from these patients with polymeric immunoglobulins will be evaluated and compared to that of HK from normal individuals...
  28. GLUCOCORTICOID-RESISTANT LEUKEMIC LYMPHOCYTES
    Allan Munck; Fiscal Year: 1990
    ..to answer the following questions: (i) Is reduction by glucocorticoids of lymphokine mRNA levels in human T lymphocytes mediated by induced protein(s)? (ii) Are those levels under negative feedback control by the lymphokines themselves?..
  29. Eosinophil, Chemokine and IL-13 Cooperativity in Asthma
    MARC ROTHENBERG; Fiscal Year: 2007
    ..Collectively, the proposed aims are designed to uncover the participation and mechanisms by which chemokines, eosinophils, and IL-13 cooperate in the induction of experimental asthma. ..
  30. OCULAR MECHANISMS OF REJECTION OF CORNEAL ENDOTHELIUM
    JOHN ROCKEY; Fiscal Year: 1990
    ..The findings in animal models will be correlated with human corneal allograft rejection by immunohistochemical staining of DR and DP/DQ antigens in rejected corneas and in corneas from chronically inflamed eyes...
  31. REGULATION OF PRODUCTION OF GAMMA INTERFERON IN TUMOR
    Howard Johnson; Fiscal Year: 1990
    ..The studies also result in the development of the reagents and tools for the ultimate cloning of the AVP receptor...
  32. IMMUNODOMINANT TARGETS OF CMI TO CRYPTOSPORIDIUM
    Jan Mead; Fiscal Year: 2009
    ..This will be accomplished by immunizing mice with a DNA construct of these antigens, assessing their ability to elicit immune responses, and challenging mice with C. parvum to determine the degree of protection achieved. ..
  33. MOLECULAR BASIS OF INTERFERON ACTION--RELATION TO M.S.
    Richard Ransohoff; Fiscal Year: 1992
    ..We will then clarify whether Ia expression on human astrocytes can e inhibited by other interferons or prostaglandins. These experiments will address issues of fundamental and clinical relevance in intrathecal immune responses...
  34. MECHANISMS OF DRUG ACTION IN TUMOR CELL DIFFERENTIATION
    MICHAEL MORIN; Fiscal Year: 1990
    ....
  35. INTERFERON REGULATORY FACTOR 2 FUNCTIONS
    George Blanck; Fiscal Year: 2002
    ..If so, this would be the first demonstration of a role for IRF-2 mutations in human tumor. Methods: EMSA, in vivo footprinting, DNA transfection, DNA sequencing, DNA cloning. ..
  36. GAMMA-INTERFERON INDUCIBLE GENES IN PHAGOCYTIC CELLS
    Stephen Chanock; Fiscal Year: 1990
    ....
  37. STUDIES ON THE IMMUNOLOGICAL BASIS OF FETAL TOLERANCE
    Arthur Malley; Fiscal Year: 1993
    ....
  38. IRREVERSIBLE GROWTH ARREST AND SQUAMOUS DIFFERENTIATION
    BETH HARVAT; Fiscal Year: 2001
    ....
  39. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....
  40. Retrograde Dystrophic Influence of IFN-gamma on Neurons
    Pamela Lein; Fiscal Year: 2006
    ..abstract_text> ..
  41. NOVEL MACROPHAGE DERIVED INTERFERON INDUCED CYTOKINES
    HYUN SHIN; Fiscal Year: 1993
    ....
  42. Differential Roles of TLR2 and TLR4 in Adaptive Immunity
    Matthew Fenton; Fiscal Year: 2004
    ..abstract_text> ..
  43. CD8+ T CELLS IN PRIMARY INFECTION
    Roberta Kamin Lewis; Fiscal Year: 1999
    ..3) To estimate the clonotypic diversity of this subset using standard V beta chain subset analysis. ..
  44. HUMAN LYMPHOCYTE RESPONSES TO INFLUENZA VIRUS INFECTION
    Francis Ennis; Fiscal Year: 1990
    ..The results of these experiments should provide basic insights into our understanding of the specificity and roles of human influenza specific CTLs, and their immunoregulatory relationships with interferon gamma...
  45. REGULATION OF C1 INHIBITOR SYNTHESIS AND CATABOLISM
    Bruce Zuraw; Fiscal Year: 1992
    ..This will be useful not only in the treatment of Clinh deficient patients, but also to limit contact and classical complement system activation in other inflammatory diseases...
  46. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2002
    ..abstract_text> ..
  47. Transgenic Cytokines in COPD
    Tao Zheng; Fiscal Year: 2007
    ..3) Characterize the expression and roles of IL-13 and/or IFN-gamma in murine CS-induced emphysema. ..
  48. TUMOR CELL KILLING BY MACROPHAGES--MOLECULAR MECHANISMS
    Joshua Farber; Fiscal Year: 1990
    ..The specific aims are directed at achieving the overall goal of understanding the molecular mechanisms of macrophage activation in order to control and exploit this system for the treatment of human disease...
  49. HCMV Glycoprotein B-Induced A Signal Pathway
    Hua Zhu; Fiscal Year: 2006
    ..2) Mutate two GAS elements in the HCMV major IE promoter and examine their roles in viral gene expression and replication. ..
  50. B CELL & T CELL RECOGNITION SITES OF P FALCIPARUM GP195
    Sandra Chang; Fiscal Year: 1993
    ....
  51. IMMUNOTHERAPY FOR PRIMARY BRAIN GLIOMA
    CAROL KRUSE; Fiscal Year: 2000
    ..Accordingly, we will also test the effect of dexamethasone on immuno- and gene therapeutic regimens shown effective by the experiments described in the aims listed above. ..
  52. IMMUNOBIOLOGY OF UVL-INDUCED TUMORS
    RAYMOND DAYNES; Fiscal Year: 1992
    ....
  53. CYTOKINES IN BONE
    Joseph Lorenzo; Fiscal Year: 1992
    ..In addition, I wish to examine whether TNF is also spontaneously produced by bone cultures. If it is, I will perform similar studies to determine its role in bone cell function...
  54. ROLE OF ENDOCYTOSIS IN CELL RECOGNITION
    Peter Cresswell; Fiscal Year: 2010
    ..These studies will unravel novel features of MHC class ll-restricted antigen processing which may prove of clinical importance in immunological diseases, particularly autoimmunity. ..
  55. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2004
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  56. Suppression of CYP2E1 in drug induced liver injury
    Mark Linder; Fiscal Year: 2007
    ..These findings may lead to development of a diagnostic test for identifying susceptible individuals and provide insight into potential therapeutic or preventive approaches. ..
  57. AUGMENTATION OF HIV-SPECIFIC CYTOTOXICITY BY IL-12
    Elizabeth McFarland; Fiscal Year: 1999
    ....
  58. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  59. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  60. Dendritic Cells and Breast Cancer Immunity
    A Palucka; Fiscal Year: 2004
    ..Overall, this proposal will permit us to demonstrate that efficient breast cancer immunity can be generated and used to reject the tumor thus permitting development of novel treatment modalities in breast cancer. ..
  61. Gene Expression Analyses During IFN Antiviral Therapy
    Robert Lanford; Fiscal Year: 2005
    ..These data will help determine why interferon therapy is often unsuccessful for chronic HCV infections and provide cellular targets for future therapies. ..
  62. Vaccine Induced Mucosal Protection Against TB Infection
    DANIEL HOFT; Fiscal Year: 2005
    ..Prime/boosting strategies found to prevent BCG infection after aerosol challenges will be studied for the ability to prevent infection with virulent M. tuberculosis by aerosol challenge. ..