interferon type i

Summary

Summary: Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).

Top Publications

  1. pmc A diverse range of gene products are effectors of the type I interferon antiviral response
    John W Schoggins
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 472:481-5. 2011
  2. ncbi Mechanisms of type-I- and type-II-interferon-mediated signalling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 710 North Fairbanks Court, Olson 8250, Chicago, Illinois 60611, USA
    Nat Rev Immunol 5:375-86. 2005
  3. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
  4. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
  5. ncbi Innate immune recognition of viral infection
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    Nat Immunol 7:131-7. 2006
  6. ncbi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
  7. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
  8. ncbi Innate immunity to virus infection
    Osamu Takeuchi
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    Immunol Rev 227:75-86. 2009
  9. pmc Type I interferon: friend or foe?
    Giorgio Trinchieri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Exp Med 207:2053-63. 2010
  10. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004

Detail Information

Publications325 found, 100 shown here

  1. pmc A diverse range of gene products are effectors of the type I interferon antiviral response
    John W Schoggins
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 472:481-5. 2011
    ..Several ISGs, including ADAR, FAM46C, LY6E and MCOLN2, enhanced the replication of certain viruses, highlighting another layer of complexity in the highly pleiotropic type I interferon system...
  2. ncbi Mechanisms of type-I- and type-II-interferon-mediated signalling
    Leonidas C Platanias
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, 710 North Fairbanks Court, Olson 8250, Chicago, Illinois 60611, USA
    Nat Rev Immunol 5:375-86. 2005
    ..It is anticipated that an increased understanding of the contributions of these recently identified pathways will advance our current thinking about how interferons work...
  3. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  4. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  5. ncbi Innate immune recognition of viral infection
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    Nat Immunol 7:131-7. 2006
    ..These two classes of pattern-recognition receptor molecules are expressed in different intracellular compartments and induce type I interferon responses via distinct signaling pathways...
  6. ncbi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    ..Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis...
  7. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  8. ncbi Innate immunity to virus infection
    Osamu Takeuchi
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    Immunol Rev 227:75-86. 2009
    ..In this review, we discuss recent advances in our understanding of the mechanisms of viral RNA recognition by these different types of receptors and its relation to acquired immune responses...
  9. pmc Type I interferon: friend or foe?
    Giorgio Trinchieri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Exp Med 207:2053-63. 2010
    ....
  10. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  11. ncbi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  12. ncbi STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Nature 461:788-92. 2009
    ..Collectively, our studies indicate that STING is essential for host defence against DNA pathogens such as HSV-1 and facilitates the adjuvant activity of DNA-based vaccines...
  13. pmc Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    Ganesh A Kolumam
    Department of Immunology, University of Washington, Seattle, 98195, USA
    J Exp Med 202:637-50. 2005
    ..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
  14. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005
    ..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses...
  15. pmc Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
    Michaela Ulrike Gack
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Host Microbe 5:439-49. 2009
    ..Our findings reveal a mechanism by which influenza virus inhibits host IFN response and also emphasize the vital role of TRIM25 in modulating antiviral defenses...
  16. pmc RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    Andrea Ablasser
    Institute for Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany
    Nat Immunol 10:1065-72. 2009
    ..This pathway was important in the sensing of Epstein-Barr virus-encoded small RNAs, which were transcribed by RNA polymerase III and then triggered RIG-I activation. Thus, RNA polymerase III and RIG-I are pivotal in sensing viral DNA...
  17. pmc A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    PLoS Pathog 4:e29. 2008
    ..The development of a permissive small animal model will expedite the testing of future vaccines and therapeutic candidates...
  18. pmc Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    M Paula Longhi
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1589-602. 2009
    ..Therefore, the adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity...
  19. ncbi Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Immunity 25:349-60. 2006
    ..Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system...
  20. ncbi DUBA: a deubiquitinase that regulates type I interferon production
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 318:1628-32. 2007
    ..A discrete ubiquitin interaction motif within DUBA was required for efficient deubiquitination of TRAF3 and optimal suppression of IFN-I. Our data identify DUBA as a negative regulator of innate immune responses...
  21. ncbi RNA recognition and signal transduction by RIG-I-like receptors
    Mitsutoshi Yoneyama
    Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Immunol Rev 227:54-65. 2009
    ..This review focuses on the current understanding of the molecular machinery underlying RNA recognition and subsequent signal transduction by RLRs...
  22. pmc Inhibition of interferon signaling by dengue virus
    Jorge L Munoz-Jordan
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
    Proc Natl Acad Sci U S A 100:14333-8. 2003
    ..This protein, encoded by a positive strand RNA virus, is implicated as an IFN-signaling inhibitor...
  23. pmc Differential inhibition of type I interferon induction by arenavirus nucleoproteins
    Luis Martinez-Sobrido
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 81:12696-703. 2007
    ..Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production...
  24. ncbi Links between innate and adaptive immunity via type I interferon
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    Curr Opin Immunol 14:432-6. 2002
    ..Moreover, IFN-alpha/beta has been shown to potently enhance immune responses in vivo through the stimulation of dendritic cells. These findings indicate that IFN-alpha/beta serves as a signal linking innate and adaptive immunity...
  25. pmc New developments in the induction and antiviral effectors of type I interferon
    Su Yang Liu
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Curr Opin Immunol 23:57-64. 2011
    ..Recent studies have identified IFITM proteins as the first ISG to inhibit viral entry processes and revealed mechanistic understanding of known antiviral ISGs such as ISG15 and Viperin...
  26. pmc Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 208:2367-74. 2011
    ..IFN-I-mediated control of pDCs may explain the loss of pDCs during human infections caused by HBV, HCV, or HIV and has important therapeutic implications for settings in which IFN-I is used to treat infections and autoimmune diseases...
  27. pmc Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract
    Dane Parker
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    MBio 2:e00016-11. 2011
    ....
  28. ncbi Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses
    Yutaro Kumagai
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunity 27:240-52. 2007
    ..Thus, AMs act as a type I IFN producer that is important for the initial responses to viral infection in the lung...
  29. pmc Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus
    Luis Martinez-Sobrido
    Molecular Integrative Neuroscience Department MIND, The Scripps Research Institute, IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 80:9192-9. 2006
    ..To our knowledge, this is the first evidence of an IFN-counteracting viral protein in the Arenaviridae family. Inhibition of IFN production by the arenavirus NP is likely to be a determinant of virulence in vivo...
  30. pmc Viral tricks to grid-lock the type I interferon system
    Gijs A Versteeg
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Opin Microbiol 13:508-16. 2010
    ..Moreover, IFN antagonists are attractive targets for inhibition by small-molecule compounds...
  31. pmc The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system
    Kristy J Szretter
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 84:12125-38. 2010
    ..Our experiments suggest that MyD88 restricts WNV by inhibiting replication in subsets of cells and modulating expression of chemokines that regulate immune cell migration into the central nervous system...
  32. pmc Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus
    Luis Martinez-Sobrido
    Department of Immunology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Virol 83:11330-40. 2009
    ..In addition, A549 cells infected with rLCMV/NP*(D382A), but not with WT LCMV, produced IFN and failed to rescue replication of the IFN-sensitive Newcastle disease virus...
  33. pmc Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex
    Juan R Rodriguez-Madoz
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 84:9760-74. 2010
    ..These results provide a new mechanism by which DENV evades the immune system in humans...
  34. ncbi DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 448:501-5. 2007
    ....
  35. ncbi Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells
    Ronan Le Goffic
    Unité de Défense Innée et Inflammation, INSERM Unité 874, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    J Immunol 178:3368-72. 2007
    ..We demonstrate that the sensing of IAV by TLR3 primarily regulates a proinflammatory response, whereas RIG-I (but not MDA-5) mediates both a type I IFN-dependent antiviral signaling and a proinflammatory response...
  36. pmc Type I interferon: potential therapeutic target for psoriasis?
    Yihong Yao
    MedImmune, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 3:e2737. 2008
    ..To better understand the pathogenesis of this disease and identify potential mediators, we used whole genome array analysis to profile paired lesional and nonlesional psoriatic skin and skin from healthy donors...
  37. ncbi Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 174:4465-9. 2005
    ..Provision of the third signal by either IFN-alpha beta or IL-12 results in regulation of the expression of a number of genes, including several that encode proteins critical for effector function...
  38. pmc Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
    Roland Zust
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Nat Immunol 12:137-43. 2011
    ..This link between Mda5-mediated sensing of viral RNA and 2'-O-methylation of mRNA suggests that RNA modifications such as 2'-O-methylation provide a molecular signature for the discrimination of self and non-self mRNA...
  39. ncbi Type I interferon receptors: biochemistry and biological functions
    Nicole A de Weerd
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    J Biol Chem 282:20053-7. 2007
  40. pmc Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    Ping Hui Tseng
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA
    Nat Immunol 11:70-5. 2010
    ..Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response...
  41. ncbi Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis
    S A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Genes Immun 13:207-13. 2012
    ..The type 1 IFN-inducible gene transcripts in the blood have potential utility for monitoring disease activity in patients with DM or PM...
  42. pmc Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice
    Shigeki Nakamura
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6076, USA
    J Clin Invest 121:3657-65. 2011
    ....
  43. pmc Systematic identification of type I and type II interferon-induced antiviral factors
    Su Yang Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:4239-44. 2012
    ..These results delineate common and distinct sets of type I and type II IFN-induced genes as well as identify unique ISGs that have either broad or specific antiviral effects on these viruses...
  44. pmc Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages
    Aleksey Novikov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:2540-7. 2011
    ..tuberculosis infection the induction of type I IFNs is a major mechanism used for this purpose...
  45. pmc Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
    Arash Shahangian
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 119:1910-20. 2009
    ..Collectively, these findings highlight what we believe to be a novel mechanism by which the antiviral response to influenza sensitizes hosts to secondary bacterial pneumonia...
  46. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense...
  47. ncbi Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway
    Brandon W Higgs
    Translational Sciences, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Ann Rheum Dis 70:2029-36. 2011
    ....
  48. ncbi Antiviral innate immunity pathways
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Cell Res 16:141-7. 2006
    ..MAVS is essential for antiviral innate immunity, but it also serves as a target of Hepatitis C virus (HCV), which employs a viral protease to cleave MAVS off the mitochondria, thereby allowing HCV to escape the host immune system...
  49. pmc The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling
    Amitava Mukherjee
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 7:e1001311. 2011
    ..Taken together, these data show that CVB3 has evolved a mechanism to suppress host antiviral signal propagation by directly cleaving two key adaptor molecules associated with innate immune recognition...
  50. pmc Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 234:142-62. 2010
    ..Finally, we discuss the emergent role of pDCs and one of their receptors, tetherin, in human immunodeficiency virus pathogenesis...
  51. ncbi Type I interferons in host defense
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:373-81. 2006
    ..These advances highlight the context-specific actions of type I IFNs and clarify the multiple points at which they are integrated into both innate and adaptive immunity...
  52. ncbi Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    Jacques Banchereau
    Baylor Institute for Immmunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Immunity 25:383-92. 2006
    ..Genetic alterations in lineages other than B cells might explain other autoimmune syndromes where type I IFNs appear to be involved...
  53. pmc Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways
    Chen Zhao
    Institute for Cellular and Molecular Biology, University of Texas, 2500 Speedway, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 102:10200-5. 2005
    ..By targeting a wide array of constitutively expressed proteins, ISG15 conjugation greatly extends the repertoire of cellular functions that are affected by IFN-alpha/beta...
  54. pmc Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques
    Levelle D Harris
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 84:7886-91. 2010
    ..In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques...
  55. pmc Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
    Weiping Cao
    Emory Vaccine Center, Atlanta, GA 30329, USA
    Nat Immunol 9:1157-64. 2008
    ..Thus, mTOR signaling is crucial in TLR-mediated IFN-alpha/beta responses by pDCs...
  56. pmc Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar
    Mehul S Suthar
    Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA
    J Virol 86:7704-9. 2012
    ..These infectious clones provide new reagents to study flavivirus immune regulation and pathogenesis...
  57. pmc Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S Euclid, St Louis, MO 63110, USA
    Cell Host Microbe 11:631-42. 2012
    ..Thus, effective antiviral CD8(+)T cell responses depend on the timing and magnitude of IFN-I production...
  58. pmc Constitutive type I interferon modulates homeostatic balance through tonic signaling
    Daniel J Gough
    New York University Medical Center, New York, NY 10016, USA
    Immunity 36:166-74. 2012
    ....
  59. pmc Role of specific innate immune responses in herpes simplex virus infection of the central nervous system
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:2273-81. 2012
    ..These results illustrate the complex but important roles that innate immune receptors play in host responses to HSV-1 during infection of the central nervous system...
  60. pmc Dengue virus inhibits the production of type I interferon in primary human dendritic cells
    Juan R Rodriguez-Madoz
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 84:4845-50. 2010
    ..Together, our data show that inhibition of IFN-alpha/beta production by DENV in primary human moDCs is a novel mechanism of immune evasion...
  61. ncbi Induction of type I IFNs by intracellular DNA-sensing pathways
    Taner Cavlar
    Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Immunol Cell Biol 90:474-82. 2012
    ..In this review, we outline the recent advancements in the elucidation of intracellular DNA-sensing pathways and discuss the future directions of this emerging field...
  62. pmc PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 205:315-22. 2008
    ..Thus, PI3K selectively controls type I IFN production by regulating IRF-7 nuclear translocation in human pDCs and could serve as a novel target to inhibit pathogenic type I IFN in autoimmune diseases...
  63. ncbi Recognition of yeast nucleic acids triggers a host-protective type I interferon response
    Carmelo Biondo
    The Elie Metchnikoff Department, University of Messina, Messina, Italy
    Eur J Immunol 41:1969-79. 2011
    ..These data suggest that recognition of yeast nucleic acids by TLR7 and TLR9 triggers a host-protective IFN-α/β response...
  64. ncbi The type I interferon system in the development of lupus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Semin Immunol 23:113-21. 2011
    ..The possible connection between the type I IFN system and some environmental and genetic risk factors for lupus is also discussed...
  65. pmc Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase
    Laure Campillo-Gimenez
    INSERM U841, Faculté Créteil Henri Mondor, 8 rue du General Sarrail, 94010 Creteil, France
    J Virol 84:1838-46. 2010
    ....
  66. ncbi A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis
    M Comabella
    Unitat de Neuroimmunologia Clinica, CEM Cat Edif EUI 2 feminine planta, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Brain 132:3353-65. 2009
    ....
  67. pmc The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8
    Prafullakumar Tailor
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:228-39. 2007
    ..Together, these data indicate that IRF8 magnifies the second phase of IFN transcription in DCs by prolonging binding of basic transcription machinery to the IFN promoters, thereby playing a role in innate immunity...
  68. pmc Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 84:9452-62. 2010
    ..These virus-host interactions may play important roles in the pathogeneses of LCMV and other human arenavirus diseases...
  69. pmc Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
    Michal Caspi Tal
    Department of Immunobiology, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:2770-5. 2009
    ....
  70. ncbi A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists
    Michael R York
    Boston University Medical Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:1010-20. 2007
    ..In this study we examined gene expression by peripheral blood mononuclear cells (PBMCs) from patients with systemic sclerosis (SSc) to better understand the dysregulation of the immune system in this disease...
  71. pmc Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus
    Matteo Iannacone
    Immune Disease Institute and Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 465:1079-83. 2010
    ..These results identify SCS macrophages as crucial gatekeepers to the CNS that prevent fatal viral invasion of the nervous system on peripheral infection...
  72. ncbi The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    Bo Zhong
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Immunity 29:538-50. 2008
    ..Our results suggest that MITA is a critical mediator of virus-triggered IRF3 activation and IFN expression and further demonstrate the importance of certain mitochondrial proteins in innate antiviral immunity...
  73. ncbi IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes
    Pamela I Osterlund
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 179:3434-42. 2007
    ....
  74. pmc Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
    Jiangao Zhu
    Department of Medicine, Duke University Medical Center, Box 3502, Durham, NC 27710, USA
    J Virol 81:3170-80. 2007
    ..Our results that suggest strategies to interfere with type I IFN pathway may improve the outcome of adenovirus-mediated gene therapy, whereas approaches to activate the type I IFN pathway may enhance vaccine potency...
  75. ncbi Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
  76. pmc Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    ..This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV...
  77. ncbi Pharmacological induction of interferon type I activity following treatment with rituximab determines clinical response in rheumatoid arthritis
    Saskia Vosslamber
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 70:1153-9. 2011
    ..The goal of this study was to provide insight into pharmacological changes in peripheral blood that are associated with clinical response to rituximab...
  78. ncbi Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin
    Hirokazu Shigematsu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 21:43-53. 2004
    ..These results highlight a unique developmental program of PDCs that distinguishes them from other cell types including conventional dendritic cells...
  79. ncbi The yin and yang of type I interferon activity in bacterial infection
    Thomas Decker
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Nat Rev Immunol 5:675-87. 2005
    ..Strikingly, their activity can be either favourable or detrimental, and can influence various immune effector mechanisms...
  80. pmc Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice
    Carmen Elena Gómez
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Virol 86:5026-38. 2012
    ..These findings revealed that single or double deletion of viral factors (B8 and B19) targeting the IFN pathway is a useful approach in the design of improved poxvirus-based vaccines...
  81. pmc Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1
    Atsushi Iwai
    Department of Bioresources, hHokkaido University Research Center for Zoonosis Control, North 20, West 10 Kita ku, Sapporo, Hokkaido 001 0020, Japan
    J Biol Chem 285:32064-74. 2010
    ..These findings demonstrate that the viral polymerase plays an important role for regulating host anti-viral response through the binding to IPS-1 and inhibition of IFNβ production...
  82. ncbi Viruses and interferon: a fight for supremacy
    Michael G Katze
    Department of Microbiology, University of Washington, Seattle, Washington 98195 8070, USA
    Nat Rev Immunol 2:675-87. 2002
    ..This effort must take advantage of the recent developments in functional genomics, bioinformatics and other emerging technologies...
  83. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
    ..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response...
  84. pmc A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses
    S Y Hwang
    Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Proc Natl Acad Sci U S A 92:11284-8. 1995
    ....
  85. ncbi Effects of time of progesterone supplementation on embryo development and interferon-tau production in the cow
    G E Mann
    Division of Animal Physiology, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Vet J 171:500-3. 2006
    ..05). The results demonstrate that progesterone supplementation during the postovulatory rise, but not later in the luteal phase, increases embryo development and interferon-tau production...
  86. pmc A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages
    Yu Zhou
    Division of Virology, Wuhan Centres for Disease Control and Prevention, Wuhan, China
    Immunology 131:40-9. 2010
    ..These findings indicate that TLR-3-mediated induction of multiple anti-HIV factors should be beneficial for the treatment of HIV disease where innate immune responses are compromised by the virus...
  87. ncbi Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling
    Christelle Bourgeois
    Christian Doppler Laboratory for Infection Biology, Max F Perutz Laboratories, Medical University Vienna, A 1030 Vienna, Austria
    J Immunol 186:3104-12. 2011
    ..glabrata in the host. Our data uncover for the first time a pivotal role for endosomal TLR7 signaling in fungal pathogen recognition and highlight the importance of IFNs-I in modulating the host immune response to C. glabrata...
  88. pmc Hemagglutinin-dependent tropism of H5N1 avian influenza virus for human endothelial cells
    Manuela Ocaña-Macchi
    Institute of Virology and Immunoprophylaxis IVI, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
    J Virol 83:12947-55. 2009
    ..Overall, avian H5N1 viruses have a particular receptor specificity targeting endothelial cells that is different from human influenza viruses, and this H5N1 receptor specificity could contribute to disease pathogenesis...
  89. ncbi The role of type I interferons in non-viral infections
    Christian Bogdan
    Institute of Medical Microbiology and Hygiene, Department of Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Immunol Rev 202:33-48. 2004
    ..This review summarizes the current knowledge on the production and function of IFN-alpha/beta during non-viral infections in vitro and in vivo...
  90. ncbi Type 1 interferons and the virus-host relationship: a lesson in détente
    Adolfo Garcia-Sastre
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 312:879-82. 2006
    ..The plasticity that exists in these interactions provides us with a lesson in détente...
  91. ncbi Local type I IFN receptor signaling protects against virus spread within the central nervous system
    Claudia N Detje
    Division of Immunology, Paul Ehrlich Institut, Langen, Germany
    J Immunol 182:2297-304. 2009
    ..Our data indicate that upon intranasal VSV instillation, early and localized IFNAR triggering in the glomerular layer of the olfactory bulb is critically required to prevent viral spread over the entire CNS and thus confers survival...
  92. pmc Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection
    Javier A Carrero
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:535-40. 2004
    ..Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins...
  93. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  94. pmc Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo
    Deborah J Lenschow
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 79:13974-83. 2005
    ..Finally, we demonstrate that ISG15's LRLRGG motif is also required for its antiviral activity. We conclude that ISG15 can be directly antiviral...
  95. ncbi Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    J Immunol 176:2074-8. 2006
    ..These results indicate that IFN-alphabetaR signaling in both B and T cells plays an important role in the stimulation of Ab responses by IFN-alphabeta...
  96. pmc Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
    Kindra M Kelly-Scumpia
    Department Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 207:319-26. 2010
    ..Using a low lethality sepsis model, we identify a critical role of type I IFN-dependent CXCL10 in host defense during polymicrobial sepsis by increasing neutrophil recruitment and function...
  97. pmc PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response
    Gerald Barry
    The Roslin Institute and Royal School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Gen Virol 90:1382-91. 2009
    ....
  98. pmc The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    Beichu Guo
    Department of Microbiology, Immunology, and Molecular Genetics, 8 240 Factor Building, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Clin Invest 118:1680-90. 2008
    ....
  99. pmc Species-independent bioassay for sensitive quantification of antiviral type I interferons
    Thomas Kuri
    Department of Virology, University of Freiburg, D 79008 Freiburg, Germany
    Virol J 7:50. 2010
    ..These assays however are either time-consuming and lack convenient readouts, or they are rather insensitive and restricted to IFN from a particular host species...
  100. ncbi New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Trends Mol Med 16:379-86. 2010
    ..The recent discovery of a novel T-cell subset, Th17 cells, sheds new light on type I IFNs in MS...
  101. pmc Lupus-prone New Zealand Black/New Zealand White F1 mice display endothelial dysfunction and abnormal phenotype and function of endothelial progenitor cells
    S G Thacker
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5680, USA
    Lupus 19:288-99. 2010
    ..These results further support the hypothesis that type I IFNs may play an important role in premature vascular damage and, potentially, atherosclerosis development in SLE...

Research Grants75

  1. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..Alternatively, mediators of neuropathogenesis can be targeted to alleviate collateral damage and thus, preservation of neurons in patients that suffer from acute or recurrent HSV-1 CNS or peripheral nerve infection. ..
  2. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..Understanding these pathways and the mechanisms by which viruses evade the innate immune response may lead new approaches to attenuated vaccines or antiviral drug targets specifically designed to bypass viral evasion strategies. ..
  3. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  4. Murine coronavirus neurovirulence: role of type I interferon response
    Susan R Weiss; Fiscal Year: 2013
    ..Moreover, understanding type I IFN signaling in the CNS may aid in developing or refining therapeutic applications for type I IFNs, which are currently used in treatment of MS and hepatitis C. ..
  5. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..Understanding how the immune system supports hematopoiesis is needed to develop strategies for the prevention and treatment of pancytopenia in AIDS patients. ..
  6. Alternative regulation of ISGs in WNV-infected cells
    Margo A Brinton; Fiscal Year: 2013
    ..Delineation of the viral counteraction mechanism will provide a new cell target for the development of antiviral therapeutics that may be applicable to a broad spectrum of virus infections. ..
  7. Molecular Regulation of Vascular Regression
    Roberto Nicosia; Fiscal Year: 2013
    ..Studies proposed in this grant will contribute to the VA care mission since many diseases afflicting the veteran patient population are associated with abnormal persistence or loss of angiogenic neovessels. ..
  8. Phagosomal Signals Shape Inflammatory Responses to Borrelia Burgdorferi
    Juan C Salazar; Fiscal Year: 2010
    ..abstract_text> ..
  9. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..This treatment stimulates immunity against influenza virus, as well as interferes with the virus'ability to do damage to the airways. ..
  10. Efficacy of the antiviral state versus Sindbis and Venezuelan equine encephalitis
    William B Klimstra; Fiscal Year: 2013
    ..Furthermore, these studies will provide information regarding the contribution of resistance to particular effectors to the virulence of alphaviruses in mice and humans that can be used in design of alphavirus vaccines. ..
  11. The role of plasmacytoid dendritic cells in corneal immunity
    Pedram Hamrah; Fiscal Year: 2013
    ..HSK is a leading cause of blindness. Effective therapy for HSK would significantly reduce visual impairment, increase productivity, and reduce the burden of treating HSK. ..
  12. Pathogenesis of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2011
    ..abstract_text> ..
  13. C. trachomatis-mediated signaling pathways required for Type I IFN responses
    JEFFREY RYAN BARKER; Fiscal Year: 2013
    ..In addition, we will define the host cellular pathways required for sensing intracellular molecules such as c-di-AMP. ..
  14. Anti HCV Protease Activities of Metalloporphyrins
    Warren N Schmidt; Fiscal Year: 2013
    ..The immediate goals of this application are to characterize the antiviral actions of MPs as well as establish the feasibility of these compounds for therapeutic use in humans. ..
  15. Molecular Markers in Discoid Lupus Erythematous
    BENJAMIN FRANKLIN CHONG; Fiscal Year: 2013
    ..Moreover, knowledge of genes associated with systemic involvement in DLE subjects will enhance understanding of disease course. ..
  16. Innate Immune Recognition Enhances Flavivirus Vaccine Efficacy
    Gregg N Milligan; Fiscal Year: 2010
    ....
  17. Synergistic innate immune activation and cell killing by RIG-I ligands in HCV-HCC
    Lee Gehrke; Fiscal Year: 2013
    ..This proposal has the potential to foster new ideas about how both HCV infection and the liver cancer that often follows can be treated or prevented. ..
  18. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ....
  19. Innate Immune Sensing of Rift Valley Fever Virus
    Amy G Hise; Fiscal Year: 2010
    ....
  20. Interferon Alpha: The Link Between Lupus and Endothelial Dysfunction
    JOY N BUIE; Fiscal Year: 2013
    ..Finally, the student will submit work for publication in peer-reviewed journals. ..
  21. TLR4 Signaling in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2013
    ..Our results suggest that the absence of TLR4 but not of the MyD88 adaptor protects mice from alcoholic liver disease. ..
  22. Regulation of normal and leukemic hematopoiesis by type I interferon
    Eric M Pietras; Fiscal Year: 2011
    ....
  23. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..abstract_text> ..
  24. Antibody-interferon fusion proteins for treatment of B-cell malignancies
    Sherie L Morrison; Fiscal Year: 2013
    ..B. Evaluate the in vivo efficacy of the fusion proteins against human lymphoma xenografts in combination with inhibitors of mTOR (temsirolimus) or PI3 kinase d (CAL-120). ..
  25. miR-155 regulation of cellular susceptibility to HIV-1 infection
    JULIO MARTIN-GARCIA; Fiscal Year: 2013
    ..These novel studies will shed light on our limited understanding of the interplay between miRNAs and HIV-1, and might open new avenues to explore the use of miR-155 to decrease susceptibility to HIV-1 infection. ..
  26. Analysis of Coronavirus-Host Cell Interactions
    Shinji Makino; Fiscal Year: 2013
    ....
  27. Innate Immunity: Signal Transduction and Interferon Gene Regulation
    THOMAS P MANIATIS; Fiscal Year: 2010
    ..The results could lead to the development of treatments for infectious, inflammatory, and autoimmune diseases, while additionally identifying therapeutic targets for antiviral agents. ..
  28. Type I interferon-induced protection from staphylococcal pore-forming toxins
    TIMUR OLEGOVICH YAROVINSKY; Fiscal Year: 2010
    ..aureus. We propose to evaluate whether interferon-induced protection from alpha-toxin benefits the host and has a therapeutic potential for treatment of staphylococcal infections. ..
  29. T cell regulation by IDO-competent plasmacytoid dendritic cells
    ANDREW LEE MELLOR; Fiscal Year: 2010
    ..In mice, interferon type I (IFN1) was the obligate upstream IDO inducer in splenic IDO-competent pDCs after B7 ligation...
  30. Infection with Bordetella pertussis exacerbates Influenza infection
    VICTOR ISAAC AYALA; Fiscal Year: 2010
    ..pertussis but more importantly lead to the development of new and improved diagnostics and treatment for coinfections. ..
  31. PATHOGENESIS OF AUTOANTIBODIES IN PRISTANE-INDUCED LUPUS
    Westley H Reeves; Fiscal Year: 2013
    ..In view of the IRF5/7 gene polymorphisms associated with human SLE, there is reason for optimism that this two-pronged approach may be beneficial in both murine and human lupus. ..
  32. Regulation of the type I interferon response by IRFs in inflammatory arthritis
    SUSAN ELAINE SWEENEY; Fiscal Year: 2013
    ..These studies will have major implications for targeting the IRF transcription factor family to treat autoimmune and inflammatory diseases and are relevant to NIAMS mission to support research into the causes of arthritis. ..
  33. Role of TRIM79 in innate immunity to tick-borne encephalitis virus
    ROGER TRAVIS TAYLOR; Fiscal Year: 2013
    ....
  34. Small Molecule Inhibitors of the Poxvirus Type I Interferon Binding Protein
    Luis J Sigal; Fiscal Year: 2013
    ....
  35. Interactions of pDCs with Aspergilus
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..Moreover, the knowledge gained may lead to novel strategies to prevent and treat invasive mycoses. ..
  36. The Role of Innate Immunity in Systemic and Cutaneous Lupus
    JOANNE MICHELLE KAHLENBERG; Fiscal Year: 2013
    ..Development of a persistent lupus-like rash, inflammatory infiltrate composition and acceleration of systemic disease development will be monitored. ..
  37. Innate Immune Activation in Malaria
    Douglas T Golenbock; Fiscal Year: 2013
    ..The purpose of this grant is to gain a better understanding of why malaria causes disease in the hopes that better therapies can be devised, including an effective vaccine that might prevent malaria. ..
  38. New Strategies to Decipher the Pathophysiology of Chronic Fatigue Syndrome
    Vincent C Lombardi; Fiscal Year: 2013
    ....
  39. MODULATION OF INNATE AND ADAPTIVE IMMUNITY BY DENGUE VIRUS
    Ana Fernandez-Sesma; Fiscal Year: 2012
    ..Understanding the modulation of cytokine responses by DenV, such as type I interferon (IFN), can help in the design of therapeutic targets to fight DenV. ..
  40. A role for autophagy in increased cytosolic viral signaling in aging
    Michal Caspi Tal; Fiscal Year: 2011
    ..I will then examine how this impacts the pathologies seen in aging, specifically the way in which a cell recognizes and responds to viral infection with age. ..
  41. Neutrophil Subsets in Post-Viral Asthma
    Dorothy S Cheung; Fiscal Year: 2013
    ....
  42. The Role of IL-17 Axis in Inflammatory Myositis
    Ann M Reed; Fiscal Year: 2013
    ....
  43. Can Sexually Transmitted Pathogens Impact the Efficacy of HIV-1 Microbicides?
    SUSANA NOEMI ASIN; Fiscal Year: 2013
    ....
  44. Novel Vaccination Strategies Against Epidemic and Pandemic Influenza Viruses to I
    Murali Krishna Kaja; Fiscal Year: 2012
    ..This knowledge will not only contribute to improved vaccination strategies against influenza, especially in elderly, but also has implications for novel vaccination strategies against a variety of diseases. ..
  45. Viral Mediated Type I Interferon Induction
    Genhong Cheng; Fiscal Year: 2013
    ..We will also develop novel therapeutic agents to treat disease models associated with DNA virus infections such as genital herpes. ..
  46. Influenza A Inhibits TH17 Host Defense Against Bacterial Pneumonia
    John F Alcorn; Fiscal Year: 2013
    ..These data may be directly applicable to the hospital setting and may reveal novel therapeutic strategies that would decrease morbidity and mortality, and improve patient outcome. ..
  47. Novel Strategies for Cancer Immunotherapy in Stem Cell Transplant
    Yiping Yang; Fiscal Year: 2013
    ....
  48. MECHANISM OF ACTION OF ANTITUMOR DRUGS
    Leroy F Liu; Fiscal Year: 2013
    ..Successful completion of the proposed studies will not only advance our understanding of the mechanism of action of Top1-targeting drugs but also may lead to development of better treatment strategies for Top1 drug-based cancer therapy. ..
  49. Pathways regulating plasmacytoid dendritic cells in Peyers Patches
    Stephanie S Watowich; Fiscal Year: 2013
    ....
  50. Targeting Metastasis Induced by Mesenchymal Stem Cells in the Tumor Stroma
    Shrikanta Chattopadhyay; Fiscal Year: 2013
    ..The proposed studies are ideally suited for my goal of transitioning into an academic physician-scientist specialized in small-molecule inhibitors of the breast cancer microenvironment. ..
  51. Arenavirus Subversion of Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2013
    ..The long-term impact of our studies will be to translate this new knowledge into novel therapeutic modalities in human infections with arenaviruses and may be other DC-tropic viruses. ..
  52. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2013
    ....
  53. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2013
    ..abstract_text> ..
  54. The IRF - type I interferon system in T cell-mediated immune tolerance
    Michael David; Fiscal Year: 2013
    ..The proposed studies will extend our understanding of the contributions of IRFs and type I interferons in the development of Treg cells that are essential in the maintenance of self-tolerance. ..
  55. Cellular Determinants of Apoptosis in Virus-Infected Cells
    Ganes C Sen; Fiscal Year: 2013
    ..Finally, genetically modified mice, including new IRF-3 mutant knock-in mice which have been generated for this project, will be used to assess the in vivo contribution of RIPA in controlling viral pathogenesis. ..
  56. Dendritic Cell Restriction and Innate Immune Sensing of HIV Infection
    Dan Littman; Fiscal Year: 2011
    ..Results of these studies may provide new approaches for inducing strong protective immune responses against the virus. ..
  57. Investigation of Regulatory T Cells in Veterans with Rheumatologic Disease
    Amit Golding; Fiscal Year: 2013
    ....
  58. IMPACT OF PLASMACYTOID DENDRITIC CELLS ON TYPE I DIABETES PATHOGENESIS
    Melissa Swiecki; Fiscal Year: 2013
    ....
  59. Targeting TAM Receptors to Modulate Inflammation and Autoimmunity
    Philip L Cohen; Fiscal Year: 2013
    ..If these antibodies have such an effect on models of arthritis and lupus in mice, a parallel approach to human inflammatory illnesses may open up, with the possibility of controlling many autoimmune and inflammatory diseases. ..
  60. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark T Heise; Fiscal Year: 2012
    ....
  61. Regulation of AU-rich element-mediated mRNA decay
    Ching Yi Chen; Fiscal Year: 2013
    ..Understanding the regulation of mRNA degradation would provide insights into the disease pathogenesis. Our research should allow for the development of alternative treatments for immune and inflammatory diseases and cancer. ..
  62. CC-chemokines in Listeria infection.
    Eric G Pamer; Fiscal Year: 2013
    ..Deciphering mechanisms driving monocyte trafficking may lead to new approaches to enhance immune defense against infection. ..
  63. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2007
    ..Information gained from the proposed experiments will have implications for the treatment of HIV infected patients with immunomodulatory therapies, such as IFN-alpha. ..
  64. The Role of Ubiquitination on TBK1 Function
    Roosevelt Boursiquot; Fiscal Year: 2010
    ..A greater understanding of TBK1-mediated antiviral defense may suggest potential therapeutic targets in clinical applications. ..
  65. Interferon and Raloxifene Effects on Cancer Cells
    CHERYL ROSENFELD; Fiscal Year: 2007
    ..The University is in the process of developing a Comparative Oncology Program. The campus provides a rich mix of disciplines and a collaborative environment, in which Dr. Rosenfeld is expected to continue to thrive. ..
  66. Activation of innate antiviral defenses by LTbetaR
    CHRISTOPHER BENEDICT; Fiscal Year: 2005
    ..abstract_text> ..
  67. VIRUS/HOST INTERACTIONS MODULATED BY HEPATITIC C VIRUS
    Radhakrishnan Padmanabhan; Fiscal Year: 2001
    ..abstract_text> ..
  68. RSV Inhibition of Interferon-Dependent Airway Immunity
    Dwight Look; Fiscal Year: 2007
    ..abstract_text> ..
  69. Lassa and Nipah Virus Interferon-Antagonists
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..abstract_text> ..
  70. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2002
    Plasmacytoid dendritic cells (pDC) or natural interferon type I producing cells play an important role in linking innate and acquired immunity...
  71. Genotypic Variation and B. burgdorferi Pathogenesis
    Ira Schwartz; Fiscal Year: 2009
    ..The proposed studies will shed light on the basis for symptom development in infected patients and on the factors contributing to dissemination of B. burgdorferi in humans. ..
  72. Type I interferon in LPS/CpG-induced lethal toxic shock
    Jean van Seventer; Fiscal Year: 2005
    ....
  73. INTERFERON ALPHA/BETA RECEPTORS
    Sidney Pestka; Fiscal Year: 2004
    ..Identification of all the pathways initiated through the Type I interferon receptor will provide an opportunity to develop new interferons and new approaches to treat many diseases. ..
  74. Alphavirus Modulation of the Host Type I Interferon System
    Catherine Cruz; Fiscal Year: 2010
    ....
  75. Role of TLR3-TRIF Variants in host susceptibility to viral myocarditis
    NEIL BOWLES; Fiscal Year: 2009
    ..In this project we will look at changes in the immune system and determine whether these could make a person more likely to develop heart disease following virus infection. ..