endothelin 1


Summary: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)

Top Publications

  1. ncbi Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation
    Donatella Del Bufalo
    Experimental Chemotherapy Laboratories, Regina Elena Cancer Institute, Rome, Italy
    Mol Pharmacol 61:524-32. 2002
  2. pmc Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1
    Feng Dong
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 3375, USA
    Br J Pharmacol 145:323-33. 2005
  3. ncbi Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Hypertension 39:81-6. 2002
  4. ncbi Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines
    K Grant
    Department of Surgery, Royal Free and University College Medical School, University College London, London, UK
    Br J Surg 94:106-12. 2007
  5. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
  6. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
  7. ncbi The endothelin system in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, via Massarent 9, 40138 Bologna, Italy
    Cardiovasc Res 61:227-37. 2004
  8. pmc Endothelin-1: a multifunctional molecule in cancer
    K Grant
    Department of Surgery, Royal Free and University College London Medical School, UK
    Br J Cancer 88:163-6. 2003
  9. ncbi Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts
    Xu Shi-Wen
    Royal Free Hospital, University College London, London, UK
    Arthritis Rheum 56:4189-94. 2007
  10. ncbi Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat
    Marie Henriksson
    Division of Experimental Vascular Research, Lund University Hospital, Wallenberg Neurocentrum, BMC A13, 221 84 Lund, Sweden
    Stroke 34:1479-83. 2003

Detail Information

Publications337 found, 100 shown here

  1. ncbi Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation
    Donatella Del Bufalo
    Experimental Chemotherapy Laboratories, Regina Elena Cancer Institute, Rome, Italy
    Mol Pharmacol 61:524-32. 2002
  2. pmc Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1
    Feng Dong
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 3375, USA
    Br J Pharmacol 145:323-33. 2005
    ..3 In summary, our results suggest that ET-1 affects oxidative stress, proliferation and apoptosis possibly through ET(B), NADPH oxidase, Akt, Bax and caveolin-1-mediated mechanisms...
  3. ncbi Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Hypertension 39:81-6. 2002
    ..Cardiomyocytes were treated with 100 nmol/L endothelin 1 (ET) and 10 micromol/L phenylephrine (PE) to induce myocardial cell hypertrophy...
  4. ncbi Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines
    K Grant
    Department of Surgery, Royal Free and University College Medical School, University College London, London, UK
    Br J Surg 94:106-12. 2007
    ..The peptide endothelin (ET) 1 promotes proliferation in a number of epithelial cancers. The aim of this study was to identify the mechanism of ET-1-stimulated proliferation in colorectal cancer cells in vitro...
  5. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
  6. ncbi A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme
    T Thomas
    Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
    Development 125:3005-14. 1998
    ..Complete disruption of this molecular pathway results in growth failure of the branchial arches from apoptosis, while partial disruption leads to defects of branchial arch derivatives, similar to those seen in CATCH-22 syndrome...
  7. ncbi The endothelin system in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, via Massarent 9, 40138 Bologna, Italy
    Cardiovasc Res 61:227-37. 2004
    ..Additional trials with these drugs are currently ongoing. In conclusion, the hypothesis that the ET-1 system over-activation can be successfully antagonised in patients with PAH has been clearly demonstrated...
  8. pmc Endothelin-1: a multifunctional molecule in cancer
    K Grant
    Department of Surgery, Royal Free and University College London Medical School, UK
    Br J Cancer 88:163-6. 2003
    ..In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy...
  9. ncbi Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts
    Xu Shi-Wen
    Royal Free Hospital, University College London, London, UK
    Arthritis Rheum 56:4189-94. 2007
    ..Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming growth factor beta (TGFbeta) induces endothelin 1 (ET-1) in human lung fibroblasts by a Smad-independent, JNK-dependent mechanism...
  10. ncbi Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat
    Marie Henriksson
    Division of Experimental Vascular Research, Lund University Hospital, Wallenberg Neurocentrum, BMC A13, 221 84 Lund, Sweden
    Stroke 34:1479-83. 2003
    ..The aim of this study was to examine the upregulation of contractile ETB receptors in cerebral arteries after organ culture and to elucidate the intracellular pathways involved...
  11. pmc Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice
    Matthew J Campen
    Toxicology Division, Lovelace Respiratory Research Institute, Albuquerque, NM, USA
    Toxicol Appl Pharmacol 242:310-7. 2010
    ..Combined with previous studies, these results indicate that whole emissions from mobile sources may have a significant role in promoting chronic vascular disease...
  12. pmc The importance of endothelin-1 for microvascular dysfunction in diabetes
    Majid Kalani
    Department of Clinical Sciences, Karolinska Institutet, Dept of Cardiology, Danderyd Hospital, Stockholm, Sweden
    Vasc Health Risk Manag 4:1061-8. 2008
    ..In the following, the mechanisms by which ET-1 contributes to the development of diabetic microangiopathy and the potentially beneficial effect of selective ET(A) receptor antagonists are discussed...
  13. ncbi Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications
    Shali Chen
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Am J Physiol Endocrinol Metab 284:E1089-97. 2003
    ..These data indicate that, although ETs are important in increased FN production due to diabetes, the mechanisms with respect to transcription factor activation may vary depending on the microenvironment of the organ...
  14. ncbi Differential regulation of the lung endothelin system by urban particulate matter and ozone
    Errol Thomson
    Healthy Environments and Consumer Safety Branch, and Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada, K1A 0K9
    Toxicol Sci 88:103-13. 2005
    ..Taken together, our data indicate that ozone and particulate matter independently regulate the expression of lung endothelin system genes, but show complex toxicological interaction with respect to plasma ET-1...
  15. ncbi Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation
    Cristina Castañares
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas C S I C, Instituto Reina Sofía de Investigaciones Nefrológicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Cell Sci 120:1256-66. 2007
  16. ncbi The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species
    V C De Giusti
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina
    Life Sci 83:264-71. 2008
    ..The data show that the effect of a concentration of ET-1 that induces an increase in contractility of about 40% is totally mediated by an intracellular pathway triggered by mitochondrial ROS formation and stimulation of the NHE...
  17. ncbi Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway
    Danny Ramzy
    Heart Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Circulation 114:I319-26. 2006
    ..We assessed the effects of elevated ET-1 levels as seen after I/R to determine if ET-1 modulates nitric oxide (NO) production via the translocation of specific protein kinase C (PKC) isoforms...
  18. pmc Endothelin-1 inhibits apoptosis in prostate cancer
    Joel B Nelson
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Neoplasia 7:631-7. 2005
    ..These data support the combination of ET(A) antagonists and apoptosis-inducing therapies for prostate cancer treatment...
  19. ncbi Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells
    L Rosano
    Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Cancer Res 61:8340-6. 2001
    ..Therefore, ET-1 may represent a key component of more aggressive ligand-induced invasiveness of ovarian carcinoma...
  20. ncbi Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis
    M Shichiri
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Mol Endocrinol 12:172-80. 1998
    ..These results demonstrate a hitherto unappreciated role of endothelin-1 as a potent survival factor for c-Myc-dependent apoptosis, a process mediated by the ET(A) receptor and the mitogen-activated protein kinase pathway...
  21. pmc Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ET(A) receptor antagonism
    E Asham
    Departments of Surgery, Histopathology, The Royal Free and University College Medical School, 67 73 Riding House Street, London, UK
    Br J Cancer 85:1759-63. 2001
    ..05). These results suggest ET-1 is produced by colorectal cancers and may play a role in the growth of colorectal cancer acting through ET(A) receptors. ET(A) antagonists are indicated as potential anti-cancer agents...
  22. ncbi Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study
    T Asai
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 38:1321-4. 2001
    ..8 mm Hg (P=0.04) higher than in those with GG genotype. That similar results were obtained from subjects of different races suggests that the Lys198Asn polymorphism of ET-1 is involved in determination of BP levels in obese subjects...
  23. ncbi The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people
    L Tiret
    INSERM U525, 17 Rue du Fer a Moulin, 75005 Paris, France
    Hypertension 33:1169-74. 1999
    ..001). In conclusion, results from 2 independent studies suggest that the ET1/C198 polymorphism is associated with blood pressure levels in overweight people...
  24. ncbi Increased endothelin-1 plasma levels in giant cell arteritis: a report on four patients
    Mona Pache
    University Eye Clinic, Basel, Switzerland
    Am J Ophthalmol 133:160-2. 2002
    ..To test the hypothesis that endothelin-1 is increased in giant cell arteritis...
  25. ncbi Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade
    Z Yang
    Cardiovascular Research, Institute of Physiology, University Zürich Irchel and Cardiology, University Hospital Zurich, Switzerland
    Circulation 100:5-8. 1999
    ..However, its mitogenic effects on vascular smooth muscle cells (SMCs) remain controversial. We investigated the role of ET-1 in human SMC growth and its synergistic effect with platelet-derived growth factor (PDGF)...
  26. pmc A review of pulmonary arterial hypertension: role of ambrisentan
    Robyn J Barst
    New York Presbyterian Pulmonary Hypertension Center, Columbia University College of Physicians and Surgeons, 3959 Broadway, BHN 2 255, NewYork, NY 10032, USA
    Vasc Health Risk Manag 3:11-22. 2007
    ..The demonstration of clinical efficacy, low incidence of acute hepatic toxicity, and low risk of drug-drug interactions support the role of ambrisentan for the treatment of PAH...
  27. ncbi Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint
    Craig T Miller
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Development 130:1353-65. 2003
    A conserved endothelin 1 signaling pathway patterns the jaw and other pharyngeal skeletal elements in mice, chicks and zebrafish...
  28. ncbi High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1
    Shali Chen
    Department of Pathology, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Am J Physiol Cell Physiol 284:C263-72. 2003
    ..ET receptor blockade also prevented these HG- and ET-mediated changes. The results of this study indicate that glucose-induced increased FN production in diabetes may be mediated via ET-dependent NF-kappaB and AP-1 activation...
  29. pmc Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein
    Angela Clerk
    Cardiac Medicine Section, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Biochem J 368:101-10. 2002
    ..Thus whereas ERKs are the principal MAPKs required for c- jun transcription, JNKs are necessary to stabilize c-Jun for efficient up-regulation of the protein...
  30. ncbi Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl
    Elzbieta Polska
    Department of Clinical Pharmacology, Allgemeines Krankenhaus Wien, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Arch Ophthalmol 120:348-52. 2002
    ..In patients with normal-tension glaucoma, ocular blood flow abnormalities may be associated with dysfunction of the endothelin 1 (ET-1) regulation system.
  31. ncbi Association of endothelin-1 gene variant with hypertension
    Jing Ji Jin
    Department of Geriatric Medicine, School of Medicine, Ehime University, Onsen gun, Ehime, Japan
    Hypertension 41:163-7. 2003
    ..Considering the combined impact of obesity and hypertension on the development of cardiovascular and cerebrovascular disorders, T allele carriers might represent elective targets for therapy to lower their body weight...
  32. ncbi Aerobic exercise training reduces plasma endothelin-1 concentration in older women
    Seiji Maeda
    Centre for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305 0006, Japan
    J Appl Physiol 95:336-41. 2003
    ..e., prevention of progression of hypertension and/or atherosclerosis by endogenous ET-1)...
  33. ncbi sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development
    C T Miller
    Institute of Neuroscience, Eugene, OR 97403 1254, USA
    Development 127:3815-28. 2000
    ..Collectively our results support a model for dorsoventral patterning of the gnathostome pharyngeal arches in which Et-1 in the environment of the postmigratory cranial neural crest specifies the lower jaw and other ventral arch fates...
  34. ncbi Endothelin 1 activates and sensitizes human C-nociceptors
    Barbara Namer
    Department of Physiology and Pathophysiology, University of Erlangen Nurnberg, Germany
    Pain 137:41-9. 2008
    ..3) ET1 could have a differential role in pain compared to other chemical algogens which activate additionally or even predominantly mechano-insensitive fibers...
  35. ncbi Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..Given the tonic interaction between the ET and NO systems, we conclude that diesel exhaust inhalation alters vascular reactivity to ET-1 probably through its effects on NO bioavailability...
  36. pmc The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?
    N S Kirkby
    Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    Br J Pharmacol 153:1105-19. 2008
  37. ncbi Heparin binding EGF is necessary for vasospastic response to endothelin
    Dominique Chansel
    INSERM U702 Hôpital Tenon Université Pierre et Marie Curie, Paris, France
    FASEB J 20:1936-8. 2006
    ..This functional cascade requires modulation of agonist-induced calcium transient by EGFR and PI3K with extremely fast kinetics, suggesting a novel paradigm for GPCR-mediated calcium signaling, which may offer future therapeutic targets...
  38. ncbi A role for endothelin-2 and its receptors in breast tumor cell invasion
    Matthew J Grimshaw
    Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Cancer Res 64:2461-8. 2004
    ..We suggest that expression of ETs and their receptors by human breast tumors, particularly in conjunction with a high macrophage infiltrate, may have a role in the progression of breast cancer and the invasion of tumor cells...
  39. ncbi Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A
    Robert S Haworth
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London, UK
    J Mol Cell Cardiol 43:686-95. 2007
    ..These results show that ET1-induced PKD activation in ARVM is mediated by PKC, primarily the PKCepsilon isoform, and is suppressed by PKA activation...
  40. ncbi Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases
    Helen J Knowles
    Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Circ Res 95:162-9. 2004
    ..This represents a novel mechanism of action for hydralazine and presents HIF as a potential target for treatment of ischemic disease...
  41. ncbi The endothelin system and its potential as a therapeutic target in cardiovascular disease
    G A Gray
    Department of Pharmacology, University of Edinburgh, Scotland
    Pharmacol Ther 72:109-48. 1996
    ..The relative merits of ET-converting enzyme inhibitors and receptor antagonists for the treatment of cardiovascular disease are discussed...
  42. ncbi Chronic effects of endothelin 1 and angiotensin II on gap junctions and intercellular communication in cardiac cells
    Lioudmilla Polontchouk
    Institute of Pharmacology, Martin Luther University of Halle Wittenberg, D 06097 Halle, Germany
    FASEB J 16:87-9. 2002
    ..Thus, stimulation of the ERK and p38 signal pathways via ETA and AT1 receptors may partcipate in the regulation of cardiac gap junctions under (patho)physiological conditions...
  43. ncbi Endothelin-1 regulates cardiac L-type calcium channels via NAD(P)H oxidase-derived superoxide
    Qinghua Zeng
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA
    J Pharmacol Exp Ther 326:732-8. 2008
    ..These observations provide the first evidence that ET-1 induces the activation of L-type Ca(2+) channels via stimulation of NAD(P)H-derived superoxide production in cardiac myocytes...
  44. ncbi Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    Farhad Amiri
    Experimental Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 110:2233-40. 2004
    ..To directly test the role of endothelium-derived ET-1 in cardiovascular pathophysiology, we specifically targeted expression of the human preproET-1 gene to the endothelium by using the Tie-2 promoter in C57BL/6 mice...
  45. ncbi Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain
    P W Wacnik
    Departments of Pharmacology, University of Minnesota Schools of Medicine and Veterinary Medicine, Minneapolis, Minnesota 55455, USA
    J Neurosci 21:9355-66. 2001
    ..This model provides a unique approach for quantifying the behavioral, biochemical, and electrophysiological consequences of tumor-nerve interactions...
  46. ncbi Endothelin and the tumorigenic component of bone cancer pain
    C M Peters
    Neurosystems Center and Department of Preventive Sciences, 18 208 Moos Tower, University of Minnesota, 515 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Neuroscience 126:1043-52. 2004
  47. ncbi Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability
    Nathalie Didier
    Commissariat a l Energie Atomique CEA, Service de Pharmacologie et d Immunologie, Saclay, France
    J Neurochem 86:246-54. 2003
    ..Taken together, these results provide evidence for paracrine actions involving ET-1, TNF-alpha and IL-1beta between human astrocytes and BMVECs, which may play a central role in BBB breakdown during CNS inflammation...
  48. ncbi Endothelin-1: the yin and yang on vascular function
    Flora Linda Marasciulo
    Department of Pharmacology and Human Physiology, Medical School University of Bari, Italy
    Curr Med Chem 13:1655-65. 2006
    ..Moreover, therapeutic applications of ET-1 receptor blockers are also discussed...
  49. pmc The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes
    K Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8397, Japan
    Mol Cell Biol 21:2085-97. 2001
    ..the ANP gene, mediated repression of ANP promoter activity in ventricular myocytes and was also involved in the endothelin 1-induced increase in ANP gene transcription...
  50. ncbi Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy
    E Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Laiko General Hospital, University of Athens, Athens, Greece
    J Clin Endocrinol Metab 86:4666-73. 2001
    ..In addition, 6 months of metformin therapy reduces endothelin-1 levels and improves their hormonal and metabolic profile...
  51. ncbi Specification and morphogenesis of the zebrafish larval head skeleton
    C B Kimmel
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403 1254, USA
    Dev Biol 233:239-57. 2001
    ..We hypothesize that Endothelin-1 also is an upstream organizer of the patterns of cellular interactions during cartilage morphogenesis...
  52. pmc Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2496-503. 2005
    On the basis of previous observations, endothelin 1 (ET-1) has been suggested as contributing to the pathogenesis of Chagasic cardiomyopathy...
  53. ncbi Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis
    S Iwasa
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Atherosclerosis 146:93-100. 1999
    ..and that the enhanced ET system mediated by ET(B) receptors may play active roles in the progression of atherosclerosis...
  54. pmc Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions
    Tom W Cherng
    Physiology Group, Dept of Cell Biology and Physiology, Univ of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Am J Physiol Regul Integr Comp Physiol 297:R640-7. 2009
  55. ncbi Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:773-9. 2008
    ..The regulation of ADM by hCG and its interaction with endothelin 1 (EDN1) in the rat Leydig cells are also observed...
  56. ncbi Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents
    Valeria Camarda
    Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, via Fossato di Mortara 17, 44100 Ferrara, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:141-9. 2002
    ..Contractile responses evoked by noradrenaline (NA), angiotensin II (Ang II), endothelin 1 (ET-1) and hU-II were measured in large vessels (aorta and some large arteries and veins) of rats, guinea pigs, ..
  57. ncbi Duration of non-Insulin-dependent diabetes mellitus and the TNF-beta NcoI genotype as predictive factors in proliferative diabetic retinopathy
    K Kankova
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Ophthalmologica 215:294-8. 2001
    The object of the study was to investigate the share of the polymorphisms I/D ACE, endothelin 1 4127G/A and TNF-beta NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin-dependent diabetes mellitus (NIDDM)...
  58. ncbi Plasma endothelin-1 levels in patients with complex regional pain syndrome
    Elon Eisenberg
    Pain Relief Unit, Rambam Medical Center, Technion Israel Institute of Technology, POB 9602, Haifa 31096, Israel
    Eur J Pain 8:533-8. 2004
    ..We conclude that the plasma level of ET-1 cannot be regarded as a 'marker' for CRPS. Yet, the possibility that ET-1 is involved in the pathophysiology of CRPS has not been excluded and deserves further investigation...
  59. ncbi Effects of endothelin-1 on components of anterograde axonal transport in optic nerve
    Martha E Stokely
    Department of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Invest Ophthalmol Vis Sci 43:3223-30. 2002
    ..This study evaluates the effect(s) of a single administration of intravitreous ET-1 on anterograde axonal transport in the rat optic nerve...
  60. ncbi Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells
    Nicoletta Basilico
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Clin Sci (Lond) 103:464S-466S. 2002
    In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum-parasitized red blood cells (pRBCs)...
  61. ncbi The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1
    L Manaka
    Department of Dermatology, Tokyo Women's Medical University, Japan
    Br J Dermatol 145:895-903. 2001
    ..CONCLUSIONS: These findings suggest that the increased secretion of ET-1 leading to enhanced pigmentation in SK results from the co-ordinated increased expression of TNF-alpha and ECE-1alpha...
  62. ncbi Distribution and significance of endothelin 1 in guinea pig cochlear lateral wall
    D Y Xu
    Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China
    J Laryngol Otol 121:721-4. 2007
    b>Endothelin 1 is a vasoconstrictive peptide with many biological functions...
  63. ncbi Expression and significance of endothelin 1 in spiral ganglion cells of guinea pig
    Dingyuan Xu
    Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu 610041, China
    Int J Pediatr Otorhinolaryngol 72:189-92. 2008
    b>Endothelin 1 has many biological activities including actions in the nervous system...
  64. ncbi Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression
    Joanne G Harrison
    NHLI Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, South Kensington, London SW7 2AZ, UK
    Biochim Biophys Acta 1644:17-25. 2004
    ..Thus, phosphorylation and activation of CREB in cardiac myocytes may be effected by a range of different stimuli to influence the expression of immediate early genes such as c-jun...
  65. ncbi Interactive effects of anger expression and ET-1 Lys198Asn polymorphism on vasoconstriction reactivity to behavioral stress
    Kristen M Rabineau
    Department of Psychiatry, Medical College of Georgia, Georgia Prevention Institute, Augusta 30912, USA
    Ann Behav Med 30:85-9. 2005
    ..African Americans (AAs) are at particular risk for development of EH, report greater anger difficulties, and exhibit greater vasoconstrictive reactivity than their European American (EA) counterparts...
  66. ncbi Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy
    J I Patel
    Department of Pathology, Moorfields Eye Hospital, London, UK
    Eye (Lond) 22:223-8. 2008
  67. ncbi A role for increased mRNA stability in the induction of endothelin-1 synthesis by lipopolysaccharide
    Julie A Douthwaite
    Department of Experimental Therapeutics, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK
    Biochem Pharmacol 66:589-94. 2003
    ..These effects of LPS on mRNA stability may be a key mechanism in vascular pathologies through which many proteins are induced in response to infection...
  68. ncbi Concentration of endothelin in plasma and BALF fluid from asthmatic patients
    R Gawlik
    Department of Internal Medicine, Allergy and Clinical Immunology, Silesian University School of Medicine, Zabrze, Poland
    J Physiol Pharmacol 57:103-10. 2006
    ..We conclude that the higher levels of ET-1 in more severe asthma suggest that endothelins may contribute to the pathophysiology of the disease, its severity, and the regulation of bronchial tone...
  69. pmc Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 112:856-65. 2008
    ..PlGF levels are intrinsically elevated from the increased red cell turnover in SCD and in other chronic anemia (eg, thalassemia) and may contribute to inflammation and PHT seen in these diseases...
  70. ncbi Potential role of endothelin 1 in ischaemia-induced angiogenesis in critical leg ischaemia
    J C S Tsui
    Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
    Br J Surg 89:741-7. 2002
    ..The aim of this study was to quantify microvessels and study ET receptor expression and distribution in critically ischaemic leg muscle...
  71. ncbi Respiratory damage in children exposed to urban pollution
    Environmental Pathology, University of North Carolina at Chapel Hill, North Carolina, USA
    Pediatr Pulmonol 36:148-61. 2003
    ..Consequently, these children are potentially at risk for developing chronic lung disease and other systemic effects later in life...
  72. ncbi Expression of endothelin-1 system in a pig model of endotoxic shock
    Monica Forni
    Department of Veterinary Morphophysiology and Animal Production, University of Bologna, Italy
    Regul Pept 131:89-96. 2005
  73. ncbi Positive association, in local release, of luteal oxytocin with endothelin 1 and prostaglandin F2alpha during spontaneous luteolysis in the cow: a possible intermediatory role for luteolytic cascade within the corpus luteum
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, and Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Biol Reprod 76:965-70. 2007
    ..The bovine corpus luteum (CL) produces vasoactive substances, such as endothelin 1 (EDN1) and angiotensin II (Ang II), that mediate and progress luteolysis...
  74. ncbi Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons
    H Yamamoto
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Neuroscience 137:949-60. 2006
    ..Our results indicate that endothelin-1 enhances the response of dorsal root ganglion neurons to capsaicin in a protein kinase Cepsilon-dependent manner. Our findings may lead to a new strategy to treat pain associated with endothelin-1...
  75. pmc Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats
    Daisuke Nakano
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Hypertension 53:324-30. 2009
    ..Infusion of endothelin 1 (ET-1) significantly increased sodium excretion (U(Na)V) in female, but not male, wt rats (Delta U(Na)V: 0...
  76. ncbi Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells
    W Windischhofer
    University Children s Hospital, Division of Biochemical Analysis and Mass Spectrometry, University of Graz, Austria
    J Bone Miner Res 17:1774-84. 2002
  77. ncbi Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study
    Francesco Orio
    Department of Molecular, Clinical Endocrinology and Oncology, University Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:6072-6. 2005
    ..Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients...
  78. ncbi ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells
    Philippe Robin
    Laboratoire de Signalisation et Régulations Cellulaires, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8619, Universite de Paris Sud, 91405 Orsay Cedex, France
    Am J Physiol Cell Physiol 283:C251-60. 2002
    ..Finally, ET-1 activated Ras in a PP1- and Ro-31-8220-sensitive manner. Altogether, our results indicate that ET-1 induces ERK activation in rat myometrial cells through the sequential stimulation of PKC, Src, and Ras...
  79. pmc A common copy number variation on chromosome 6 association with the gene expression level of endothelin 1 in transformed B lymphocytes from three racial groups
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich 48109, USA
    Circ Cardiovasc Genet 2:483-8. 2009
  80. ncbi [A role of endothelin 1 in the pathogenesis of thromboangiitis obliterans (initital news)]
    Maciej Czarnacki
    Katedra i Klinika Angiologii, Nadciśnienia, Tetniczego i Diabetologii Akademii Medycznej we Wroctawiu
    Przegl Lek 61:1346-50. 2004
    ..The aim of study was a role of endothelin-1, antielastin antibodies and selectin P, L, E in the pathogenesis Buerger's disease and influence of alprostadil on these parameters...
  81. ncbi Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
    Kathryn Ivey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
    Dev Biol 255:230-7. 2003
    ..We conclude that the Galpha(q) and Galpha(11) proteins serve as the intracellular mediators of ET-1 signaling in the pharyngeal arch mesenchyme...
  82. ncbi Endothelin 1 and leptin in the pathophysiology of intrauterine growth restriction
    M Arslan
    Department of Obstetrics and Gynecology, Mersin University School of Medicine, Mersin, Turkey
    Int J Gynaecol Obstet 84:120-6. 2004
    To evaluate the relationship of endothelin 1 (ET-1) and leptin concentrations in women and newborns following a pregnancy complicated with intrauterine growth restriction (IUGR).
  83. ncbi Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme
    M Woods
    Vascular Inflammation, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Mol Pharmacol 55:902-9. 1999
  84. pmc Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide
    Stephen J Leslie
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Br J Clin Pharmacol 57:720-5. 2004
    ..The aims of the present study were to assess the vasoactive effects of these precursors as well as endothelin blockade in the human skin microcirculation, in vivo...
  85. ncbi Effects of tumour necrosis factor-alpha in the human forearm: blood flow and endothelin-1 release
    J N Patel
    Department of Medicine, Royal Free and University College London School of Medicine, Whittington Campus, London N19 3UA, UK
    Clin Sci (Lond) 103:409-15. 2002
    ..In spite of this action, TNF-alpha has a vasodilatory effect, resulting in an increase in forearm blood flow...
  86. ncbi Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation, and myocardial remodeling in rats
    David B Murray
    Department of Anatomy, Physiology, and Pharmacology, 240A Greene Hall, Auburn Univ, Auburn, AL 36849 5518
    Am J Physiol Heart Circ Physiol 287:H2295-9. 2004
    ..These findings demonstrate that ET-1 is a potent cardiac mast cell secretogogue and further indicate that ET-1-mediated mast cell degranulation is a potential mechanism responsible for myocardial remodeling...
  87. ncbi Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youth
    Yanbin Dong
    Georgia Prevention Institute Department of Pediatrics, Medical College of Georgia, Augusta 30912 3710, USA
    Hypertension 44:884-90. 2004
    ..In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth...
  88. ncbi Regulatory mechanisms of hepatic microcirculation
    Masaya Oda
    Organized Center of Clinical Medicine, International University of Health and Welfare and Department of Internal Medicine, Sanno Hospital, Tokyo 107 0052, Japan
    Clin Hemorheol Microcirc 29:167-82. 2003
  89. ncbi Involvement of phospholipase C in endothelin 1-induced stimulation of Ca++ channels and basilar artery contraction in rabbits
    Yoshifumi Kawanabe
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurosurg 105:288-93. 2006
    b>Endothelin 1 (ET-1) is a major cause of cerebral vasospasm after subarachnoid hemorrhage (SAH), and extracellular Cal++ influx plays an essential role in ET-1-induced vasospasm...
  90. ncbi Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway
    Ahmed Chahdi
    Department of Medicine, Division of Nephrology, Kidney Disease Center and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:578-84. 2005
    ..In this study we have presented evidence that treatment of human mesangial cells (HMC) with endothelin 1 (ET-1) and stimulation of adenylate cyclase with either forskolin or with the cAMP analog 8-Br-cAMP activated ..
  91. pmc Expression of endothelin 1 and its receptors in the hypoxic pregnant rat
    Larry G Thaete
    Department of Obstetrics and Gynecology, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Biol Reprod 77:526-32. 2007
    b>Endothelin 1 (EDN1) plays a primary role in the pathophysiology of hypoxia-induced fetal growth restriction in the rat...
  92. pmc Cholangiocyte endothelin 1 and transforming growth factor beta1 production in rat experimental hepatopulmonary syndrome
    Bao Luo
    Department of Internal Medicine and Liver Center, University of Alabama at Birmingham, 35294, USA
    Gastroenterology 129:682-95. 2005
    Hepatic production and release of endothelin 1 plays a central role in experimental hepatopulmonary syndrome after common bile duct ligation by stimulating pulmonary endothelial nitric oxide production...
  93. ncbi Involvement of tissue transglutaminase in endothelin 1-induced hypertrophy in cultured neonatal rat cardiomyocytes
    Xin Li
    Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing, People s Republic of China
    Hypertension 54:839-44. 2009
    ..This is probably attributable to the signaling activity of tTG rather than transglutaminase activity...
  94. ncbi Mechanism of inhibition of endothelin-1-stimulated proteoglycan and collagen synthesis in rat articular chondrocytes
    A M Khatib
    INSERM Unit 349, Lariboisiere Hospital, 75475 Paris, Cedex 10, France
    Cytokine 17:254-61. 2002
    ..In conclusion, NO, produced by rat AC in response to ET-1, counteracts the stimulation and finally induces inhibition of PG-collagen synthesis by ET-1 in these cells but NO-induced cGMP is only partially responsible for this inhibition...
  95. ncbi Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow: an endothelin receptor antagonist reduces the redistribution
    Seiji Maeda
    Department of Sports Medicine, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Circulation 106:2188-93. 2002
    ..We investigated the effects of acute endothelin-A (ETA)-receptor blockade on regional tissue blood flow during exercise in rats...
  96. ncbi Regulation of apoptosis by vasoactive peptides
    G S Filippatos
    Second Division of Cardiology, Evangelismos General Hospital, GR-11526 Athens, Greece
    Am J Physiol Lung Cell Mol Physiol 281:L749-61. 2001
    ..Each of these peptides is discussed, with specific regard to apoptosis, in terms of regulatory activity, target cell specificity, and potential role in pulmonary physiology...
  97. ncbi Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
    Alla Khodorova
    Molecular Neurobiology of Pain Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, 02115 USA
    Nat Med 9:1055-61. 2003
    ..These results indicate the existence of an intrinsic feedback mechanism to control peripheral pain in skin, and establish keratinocytes as an ET(B) receptor-operated opioid pool...
  98. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
    ..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
  99. ncbi Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension
    C Rubens
    Department of Cardiology and Pulmonology, Benjamin Franklin Hospital, Free University of Berlin, Berlin, Germany
    Chest 120:1562-9. 2001
    ..This study was undertaken to investigate possible correlations between endothelin (ET)-1 and big ET-1 plasma levels and the severity of PPH...
  100. ncbi Effects of acute delivery of endothelin-1 on retinal ganglion cell loss in the rat
    Jonathan Lau
    Department of Pathology and Molecular Medicine, HSC Rm 1R1, McMaster University, 1200 Main St West, Hamilton, Ont, Canada
    Exp Eye Res 82:132-45. 2006
    ..This potential glaucoma model leaves the optic nerve intact and may be used in subsequent experiments, which are involved in increasing RGC survival and functional recovery...
  101. ncbi Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1
    D M McMullan
    Department of Cardiothoracic Surgery, University of California, San Francisco, San Francisco, California 94143-0106, USA
    Am J Physiol Heart Circ Physiol 280:H777-85. 2001
    ..These data suggest a role for ET-1 in the rebound pulmonary hypertension noted on acute withdrawal of inhaled NO...

Research Grants71

  1. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
  2. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
  3. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  4. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of aldosterone in the progression of cardiovascular and renal disease. ..
  5. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  6. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..receptor, disrupt pulmonary vascular endothelial NO production and stimulate smooth muscle ROS production and endothelin 1 signaling, which lead to pulmonary hypertension in murine models and human subjects with SCD...
  7. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..
  8. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    ..link between complement activation and known mediators of placental ischemia-induced hypertension [AT1-AA, endothelin 1 (ET-1) and reactive oxygen species (ROS)] has NOT been investigated and is critically needed to identify the ..
  9. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
  10. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
  11. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..The information gained from this study could be useful in developing endothelin receptor antagonists as neuroprotective agents in glaucoma treatment. ..
  12. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..abstract_text> ..
  13. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
  14. PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..These studies will likely provide new diagnostic bio-markers for assessment of PHT, and novel therapeutic targets for a disease that currently has few or no therapeutic options. ..
  15. Cerebral Malaria: Mechanisms of disease and neurological salvage
    Mahalia S Desruisseaux; Fiscal Year: 2013
    ..Thus, vascular compromise and alterations in Akt and tau may be important in the pathogenesis of malaria and may provide rational targets of drug therapy to ameliorate the consequences of this infection. ..
  16. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2012
    ..abstract_text> ..
    Namasivayam Ambalavanan; Fiscal Year: 2012
  18. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2012
    ..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
  19. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
  20. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2012
    ..In PAH, smooth muscle intracellular Ca2+ is increased and endothelin 1 (ET-1) expression is up-regulated...
  21. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ..skeletal muscle microvascular perfusion and glucose uptake by activating inflammatory signaling and increasing endothelin 1 (ET- 1) secretion/action;2) AT1R blockade increases cardiac and skeletal muscle microvascular perfusion, ..
  22. Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular react
    Frank W Sellke; Fiscal Year: 2013
    ..The results of these studies may have significant implications regarding the recovery of diabetic and other patients after cardiac surgery involving cardioplegia and CPB. ..
  23. Novel functions of RGS3
    Nickolai O Dulin; Fiscal Year: 2012
    ..Therefore, defining the molecular mechanisms of T cell activation and differentiation may lead to a better understanding the pathogenesis of these diseases. ..
  24. Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger Transcrip
    David Sherris; Fiscal Year: 2010
    ..Work from this project will further advance our knowledge on zinc finger protein transcription factor/DNA interactions and may thus open the door to a whole new range of therapeutic agents. ..
  25. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..The goal of this proposal is to develop new and effective therapies to treat acute traumatic brain injury in children utilizing an immature large animal model. ..
  26. The Kidney, Hypertension, Pregnancy and Inflammation
    Babbette LaMarca; Fiscal Year: 2013
  27. Functional characterization of ATP1A1 and DEspR variants associated with essentia
    Nelson Ruiz Opazo; Fiscal Year: 2010
  28. Insulin as a Regulator of Microvascular Exchange
    Virginia H Huxley; Fiscal Year: 2013
    ..abstract_text> ..
  29. Role of Endothelin B Receptor in Vascular Protection in Females
    Raouf A Khalil; Fiscal Year: 2011
  30. Human Aging, Exercise &FMD: Translational Physiology
    Douglas R Seals; Fiscal Year: 2013
    .._OVIDED. University of Colorado-Boulder, Boulder, Colorado ..
    Costantino Iadecola; Fiscal Year: 2013
    ..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
  32. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..To test the hypothesis that Endothelin-1 and ROS facilitate T lymphocyte mediated AT1-AA induced increases blood pressure response to placental ischemia in pregnant rats . ..
  33. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
  34. The Association of Chronic Exposure to Particulate Matter Air Pollutants, Inflamm
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2013
    ..The samples will be analyzed using an automated energy dispersive XRF instrument. . ..
  35. Ah Receptor and Endothelin-Dependent Hypertension
    Mary K Walker; Fiscal Year: 2010
    ..Our results will define a novel regulatory pathway for suppression of hypoxia-induced ET- 1, which could be use to develop new therapies for ET-1-dependent cardiovascular diseases. ..
  36. Rho-kinase signaling in lung development and persistent pulmonary hypertension
    Jason Gien; Fiscal Year: 2013
    ..The strength of this proposal is the assembly of several successful scientists who will assure both progress and success in my research career and guide me towards independence as a physician scientist. ..
  37. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..The results should provide new insight into the integrative biological mechanisms by which sex hormone deficiency modulates the age-related reduction in large artery compliance in women as they transition through the menopause. ..
  38. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
  39. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2012
    ..The results derived from these studies are essential to advance our understanding in the pathogenesis of retinal vascular disease associated with retinal ischemia and may suggest novel targets for future therapeutic interventions...
  40. Evaluation of In Vitro Companion Diagnostic Monoclonal Antibodies for Use in a St
    Christopher Horvath; Fiscal Year: 2013
    ..Combined use of anti-DEspR companion diagnostic and therapeutic mAbs has the potential to alter oncology clinical practice, particularly in BCa/TNBC, as an addition to or advantage over existing treatments. ..
  41. Oxidant signaling for airway remodeling and inflammation
    YUICHIRO JUSTIN SUZUKI; Fiscal Year: 2012
    ..In addition, the results will fundamentally advance the field of lung cell biology. (End of Abstract) ..
  42. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..Assessment of these biomarkers to predict risk of dementia prior to cognitive symptoms emerging will increase ability to develop strategies of prevention and early detection. ..
  43. BK Virus Receptor and polyomavirus nephropathy
    Andrey Sorokin; Fiscal Year: 2012
    ..This proposal will uncover the protein component of BKV receptor and provide the basis for a novel strategy for therapeutical intervention in BKN to ultimately improve long-term graft survival after renal transplantation. ..
  44. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..This study uses novel technology to search for causes and potential cure of brain injury and disability caused by SAH. ..
    Michael B Fallon; Fiscal Year: 2013
  46. Mechanisms Linking Sleep-Disordered Breathing and Cardiovascular Disease
    Larissa A Shimoda; Fiscal Year: 2010
  47. Mesenchymal Cell Fate Determination by Extracellular Matrix Stiffness
    Jeffrey C Horowitz; Fiscal Year: 2013
  48. Endothelin and Angiotensin Receptor Signaling in Pulmonary Hypertension
    PETER RUDOLPH POLGAR; Fiscal Year: 2013
    ..Our experiments, including the production of peptides which interfere with negative signals of angiotensin and endothelin, are designed to lead to new approaches which should prove beneficial in the treatment of pulmonary hypertension. ..
  49. Estrogen Receptor and Cardiovascular Function
    Ellis R Levin; Fiscal Year: 2013
    ..These data may justify in the future initial translational trials in post-menopausal women, including veterans. ..
  50. Mechanobiology of Vascular Remodeling in Pulmonary Arterial Hypertension
  51. Molecular Mechanisms of Enhanced Contractility following Traumatic Brain Injury:
    Christian W Kreipke; Fiscal Year: 2011
    ..In doing so, the experiments in this proposal are designed to yield results that can quickly be translated into the clinical setting, thus off-setting the current potentially dismal outcome following exposure to TBI. ..
  52. CARMA3-mediated NF-kappaB activation in GPCR signaling pathways
    Xin Lin; Fiscal Year: 2010
  53. Endothelin Signaling and Actions in Renal Mesangium
    Andrey Sorokin; Fiscal Year: 2013
    ..The elucidation of mechanisms of ET-1-induced renal pathologies will result in understanding of the mechanisms underlying proliferation-associated and oxidative stress related renal glomerular diseases. ..
  54. Renal Endothelin-1: Control of Sodium Excretion and Blood Pressure
    MARIA MARCELA HERRERA; Fiscal Year: 2013
    ..This will provide a solid basis for the trainee to develop a multi-disciplinary program of research using physiological, cellular/molecular, and genetic techniques to achieve her goal of becoming an independent investigator. ..
  55. Compromised microcirculation in women with Polycystic Ovary Syndrome
    NINA STACHENFELD; Fiscal Year: 2010
    ..These studies also have broad public health implications because our findings on the effect of hyperandrogenism on endothelial function may provide insights that can improve cardiovascular health of all obese women and men. ..
  56. Endothelin and EGFR Activation in Pulmonary Hypertension
    Olga Rafikova; Fiscal Year: 2012
  57. Glomerular Cell-Cell Crosstalk and Injury
    Erwin P Bottinger; Fiscal Year: 2013
    ..However, podocyte morphology remains normal while podocytes initially release endothelin 1 (Edn1) to cause endothelial cell mitochondrial oxidative stress (ENDO mtStress) and endothelial dysfunction (ED)..
  58. Arterial Stiffness in the Pathogenesis of Human Pulmonary Arterial Hypertension
  59. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2013
    ..Our working hypothesis is that RXR[unreadable], directly or indirectly, represses keratinocytic expression of endothelin 1 (ET-1), SCF, POMC and FGF2 which may serve to regulate melanocytic mitogenesis in a paracrine manner...
  60. Safe, Rapid Telomere Extension to Prevent and Treat Hypertension
    Helen M Blau; Fiscal Year: 2013
  61. The Role of Endothelin in Controlling Pharyngeal Arch Morphogenesis
    MARK MASAKUNI SASAKI; Fiscal Year: 2011
  62. Disease Mechanisms in Sleep Apnea
    Virend K Somers; Fiscal Year: 2013
  63. Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular Reactivity
    Deidre Wipke Tevis; Fiscal Year: 2009
    Michael Heymann; Fiscal Year: 1999
    ATA ABDEL LATIF; Fiscal Year: 2001
  66. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2006
    ..The research will be performed primarily at the Brazil site in collaboration with Herbert Tanowitz at the US site as extension of NIH Grant AI-12770 [unreadable] [unreadable]..
  67. Role of NO and Endothelin in Human NEC
    GAIL BESNER; Fiscal Year: 2007
    ..If successful, these data could provide a platform for a prospective, randomized trial of new medical therapeutic strategies for NEC, e.g., the pharmacological manipulation of endothelin receptors. [unreadable] [unreadable]..
  68. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    Karen Fagan; Fiscal Year: 2002
    ..Improved understanding of these endogenous vasoregulatory substances, their interactions with one another, and the effect of modest hypoxia in vivo are the major goals of this proposal and may lead to new therapeutic options. ..
  70. GATA Factor Regulation of Vascular Endothelium
    EMERY BRESNICK; Fiscal Year: 2009
    ..Furthermore, GATA-2 is crucial to maintain hematopoietic stem cells and therefore uncovering mechanisms underlying GATA-2 function in any system has outstanding potential to further knowledge on adult stem cell biology. ..
  71. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..