macrophage migration inhibitory factors

Summary

Summary: Proteins released by sensitized lymphocytes and possibly other cells that inhibit the migration of macrophages away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.

Top Publications

  1. ncbi MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    Jurgen Bernhagen
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, D 52074 Aachen, Germany
    Nat Med 13:587-96. 2007
  2. ncbi MIF regulates innate immune responses through modulation of Toll-like receptor 4
    T Roger
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
    Nature 414:920-4. 2001
  3. ncbi Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK
    Thorsten Hagemann
    Cancer Research U K, Translational Oncology Laboratory, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Immunol 175:1197-205. 2005
  4. ncbi Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
    H Lue
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Oncogene 26:5046-59. 2007
  5. ncbi Macrophage migration inhibitory factor: a regulator of innate immunity
    Thierry Calandra
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Nat Rev Immunol 3:791-800. 2003
  6. ncbi Macrophage migration inhibitory factor in cardiovascular disease
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, Molekulare Herz Kreislaufforschung, RWTH Aachen University, Aachen, Germany
    Circulation 117:1594-602. 2008
  7. pmc Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion
    Alvaro Arjona
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 117:3059-66. 2007
  8. ncbi Circulating mononuclear cells in the obese are in a proinflammatory state
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, NY, USA
    Circulation 110:1564-71. 2004
  9. pmc Macrophage migration inhibitory factor: controller of systemic inflammation
    Douglas F Larson
    Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Crit Care 10:138. 2006
  10. ncbi Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma
    Yi Ren
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR, China
    Oncogene 23:4146-54. 2004

Detail Information

Publications287 found, 100 shown here

  1. ncbi MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    Jurgen Bernhagen
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, D 52074 Aachen, Germany
    Nat Med 13:587-96. 2007
    ..Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition...
  2. ncbi MIF regulates innate immune responses through modulation of Toll-like receptor 4
    T Roger
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
    Nature 414:920-4. 2001
    ..1, which is required for optimal expression of the Tlr4 gene in myeloid cells. These findings identify an important role for MIF in innate immunity and provide a molecular basis for the resistance of MIF-deficient mice to endotoxic shock...
  3. ncbi Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK
    Thorsten Hagemann
    Cancer Research U K, Translational Oncology Laboratory, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Immunol 175:1197-205. 2005
    ..We conclude that TNF-alpha, via NF-kappaB, and JNK induces MIF and EMMPRIN in macrophage to tumor cell cocultures and this leads to increased invasive capacity of the tumor cells...
  4. ncbi Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
    H Lue
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, Aachen, Germany
    Oncogene 26:5046-59. 2007
    ..Thus, MIF can directly promote cell survival through activation of the PI3K/Akt pathway and this effect is critical for tumor cell survival...
  5. ncbi Macrophage migration inhibitory factor: a regulator of innate immunity
    Thierry Calandra
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Nat Rev Immunol 3:791-800. 2003
    ....
  6. ncbi Macrophage migration inhibitory factor in cardiovascular disease
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, Molekulare Herz Kreislaufforschung, RWTH Aachen University, Aachen, Germany
    Circulation 117:1594-602. 2008
    ..The potential of targeting or exploiting MIF for therapeutic strategies or as a diagnostic marker in the management of cardiovascular diseases or disorders is scrutinized...
  7. pmc Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion
    Alvaro Arjona
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 117:3059-66. 2007
    ....
  8. ncbi Circulating mononuclear cells in the obese are in a proinflammatory state
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, NY, USA
    Circulation 110:1564-71. 2004
    ....
  9. pmc Macrophage migration inhibitory factor: controller of systemic inflammation
    Douglas F Larson
    Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Crit Care 10:138. 2006
    ..The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function...
  10. ncbi Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma
    Yi Ren
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR, China
    Oncogene 23:4146-54. 2004
    ..These results suggest that MIF may contribute to the progression of neuroblastoma by (a) inducing N-Myc expression and (b) upregulating the expression of angiogenic factors...
  11. ncbi Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes
    Ivana Cvetkovic
    Institute for Biological Research Sinisa Stankovic, 29 Novembra 142, 11000 Belgrade, Serbia and Montenegro
    Endocrinology 146:2942-51. 2005
    ....
  12. pmc MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
    Gordon A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Infect Dis 200:629-37. 2009
    ..The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA...
  13. ncbi Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women
    M Sumarac-Dumanovic
    Institute of Endocrinology, Diabetes and Diseases of Metabolism, School of Medicine, University of Belgrade, Dr Subotica 13, Belgrade, Serbia
    Int J Obes (Lond) 33:151-6. 2009
    ....
  14. pmc A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
    Michael A McDevitt
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 203:1185-96. 2006
    ..These data suggest that polymorphisms at the MIF locus may influence the levels of MIF produced in the innate response to malaria infection and the likelihood of anemic complications...
  15. ncbi The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors
    Jan Philipp Bach
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Cancer 115:2031-40. 2009
    ..The aim of this article was thus to present a detailed review of current knowledge regarding the role of MIF in CNS tumor pathophysiology...
  16. ncbi Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794 8651, USA
    Stroke 36:613-8. 2005
    ..In this study, we investigate the protection and efficacy of treatment when MIF is administered 2 hours after collagenase injection...
  17. ncbi Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase
    Daniel Aeberli
    Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, Melbourne, Australia
    FEBS Lett 580:974-81. 2006
    ..These results demonstrate that MIF regulates GC sensitivity by phosphorylation of p38, and provides a cellular mechanism for this observation, indicating that MKP-1 is a central target of this regulation...
  18. ncbi Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis
    Anke Burger-Kentischer
    Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart, Stuttgart, Germany
    Circulation 105:1561-6. 2002
    ..Macrophage migration inhibitory factor (MIF), a cytokine with potent inflammatory functions, was thus considered to be important in atherosclerotic lesion evolution...
  19. ncbi Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Atherosclerosis 200:380-8. 2008
    ....
  20. ncbi Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques
    Yao zhong Kong
    Department of Medicine, The First People s Foshan Hospital, Foshan, Guangdong, China
    Atherosclerosis 178:207-15. 2005
    ..The ability of MIF to induce MMP-9 expression in VSMCs and macrophages suggests that MIF may play a role in the destabilization of human atherosclerotic plaques...
  21. ncbi Quantification of macrophage migration inhibitory factor mRNA expression in non-small cell lung cancer tissues and its clinical significance
    Makiko Tomiyasu
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Clin Cancer Res 8:3755-60. 2002
    ..In this study, we quantified MIF mRNA expression of non-small cell lung cancer tissues and examined its relationship with clinicopathological factors...
  22. pmc Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor
    H W Sun
    Department of Pharmacology, Yale University, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:5191-6. 1996
    ..The elucidated structure for MIF is unique among cytokines or hormonal mediators, and suggests that this counterregulator of glucocorticoid action participates in novel ligand-receptor interactions...
  23. pmc Growth factor-induced delayed early response genes
    A Lanahan
    Howard Hughes Medical Institute, Baltimore, Maryland
    Mol Cell Biol 12:3919-29. 1992
    ..In 3T3 cells, the delayed early gene response to growth factors appears to be at least as complex as the immediate-early gene response previously described...
  24. ncbi Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma
    Eiji Hira
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Izumo, Japan
    Cancer 103:588-98. 2005
    ..However, the role of MIF in tumor angiogenesis and patient prognosis has not been examined in patients with HCC...
  25. ncbi Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production
    Hiroyuki Tamaki
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Gastroenterology 131:1110-21. 2006
    ..In this study, we investigated the significance of TRX in patients with inflammatory bowel disease (IBD) and the ability and mechanism to ameliorate experimental colitis...
  26. pmc MIF signal transduction initiated by binding to CD74
    Lin Leng
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 333 Cedar St, P O Box 208031, New Haven, CT 06520 8031, USA
    J Exp Med 197:1467-76. 2003
    ..These data provide a molecular basis for MIF's interaction with target cells and identify it as a natural ligand for CD74, which has been implicated previously in signaling and accessory functions for immune cell activation...
  27. ncbi Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)
    Anke Burger-Kentischer
    Fraunhofer Institute, Stuttgart, Germany
    Atherosclerosis 184:28-38. 2006
    ..Thus, although MIF's role is not directly linked to plaque volume expansion, in this mouse model of spontaneous atherogenesis, MIF plays an important role in intimal inflammation...
  28. pmc A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens
    G J Wistow
    Section on Molecular Structure and Function, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:1272-5. 1993
    ..The relatively abundant expression of MIF in lens may have clinical significance, with the possibility of involvement in ocular inflammations that may follow damage to the lens...
  29. ncbi Identification of macrophage migration inhibitory factor (MIF) in human skin and its immmunohistochemical localization
    T Shimizu
    Department of Dermatology, School of Medicine, Hokkaido University, Sapporo, Japan
    FEBS Lett 381:199-202. 1996
    ..The pathophysiological role of MIF in human skin remains undefined; however, the present results indicate that MIF may play an important role in immunity, inflammation and cellular differentiation of epidermal cells...
  30. ncbi Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis
    Yoshitaka Sakai
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Gastroenterology 124:725-36. 2003
    ..The aim of this study was to clarify the role of MIF in acute pancreatitis (AP)...
  31. ncbi Interleukin-1beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
    Ayumi Honda
    Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Dermatol Sci 49:63-72. 2008
    ..Matrix metalloproteinases (MMP)-1 is a member of the MMP family and degrades types I and III collagens, which are the major structural components of the dermis...
  32. pmc Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer
    Marc McClelland
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 174:638-46. 2009
    ..We also found that MIF induced angiogenic CXC chemokine expression in an autocrine manner in vitro, a function that was specifically inhibited by antibodies to CD74...
  33. ncbi Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration
    A Hermanowski-Vosatka
    Departments of Endocrinology and Chemical Biology and of Immunology and Rheumatology, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065, USA
    Biochemistry 38:12841-9. 1999
    ..These data suggest that this enzymatic activity of MIF does not play a role in its migration inhibiting properties...
  34. ncbi Cloning the human gene for macrophage migration inhibitory factor (MIF)
    V Paralkar
    Section on Molecular Structure and Function, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 19:48-51. 1994
    ..Northern blot analysis shows a single size of MIF mRNA (about 800 nt) in all human tissues examined. In contrast to previous reports, we find no evidence for multiple genes for MIF in the human genome...
  35. ncbi Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1
    Thierry Roger
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 35:3405-13. 2005
    ..Taken together, these data identify MKP-1 as a molecular target of MIF-glucocorticoid crosstalk and provide a molecular basis for the control of macrophage responses by a pair of physiological regulators of innate immunity...
  36. ncbi MIF loss impairs Myc-induced lymphomagenesis
    F Talos
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Cell Death Differ 12:1319-28. 2005
    ..Collectively, these results indicate that MIF promotes Myc-mediated tumorigenesis, at least in the B-lymphoid compartment, and implicate MIF as a mediator of malignant cell growth in vivo...
  37. ncbi Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria
    Gordon A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, PA 15261, USA
    Clin Immunol 119:219-25. 2006
    ..These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria...
  38. pmc Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites
    Peter D Senter
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Proc Natl Acad Sci U S A 99:144-9. 2002
    ....
  39. pmc Migration inhibitory factor expression in experimentally induced endotoxemia
    M Bacher
    Picower Institute for Medical Research, Manhasset, New York 10021, USA
    Am J Pathol 150:235-46. 1997
    ....
  40. ncbi Insight into the biology of macrophage migration inhibitory factor (MIF) revealed by the cloning of its cell surface receptor
    Lin Leng
    Department of Medicine, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven CT 06520 8056, USA
    Cell Res 16:162-8. 2006
    ..The MIF receptor, like MIF, does not fall into any established family of protein mediators, providing both new challenges and opportunities for the structural and functional analysis of MIF signal transduction...
  41. pmc Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization
    Millicent Winner
    Molecular Targets Program, James Graham Brown Cancer Center and Department of Radiation Oncology, University of Louisville, 580 South Preston Street, Louisville, KY, USA
    Cancer Res 67:186-93. 2007
    ..This functional interdependence between HIF-1alpha and MIF may represent an important and previously unrecognized pro-tumorigenic axis...
  42. pmc Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children
    Ian A Clark
    Dept of Biochemistry, Australian National University, Canberra, Australia
    Malar J 2:6. 2003
    ..Here we report on the cellular distribution, by immunohistochemistry, of migration inhibitory factor (MIF) and inducible nitric oxide synthase (iNOS) in this disease, and in sepsis...
  43. ncbi Neutralization of macrophage migration inhibitory factor-novel approach for the treatment of immunoinflammatory disorders
    Ivana Cvetkovic
    Institute for Biological Research Sinisa Stankovic, Despota Stefana 142, 11000 Belgrade, Serbia
    Int Immunopharmacol 6:1527-34. 2006
    ....
  44. pmc Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response
    Robert A Mitchell
    Picower Institute for Medical Research, New York, NY 11030, USA
    Proc Natl Acad Sci U S A 99:345-50. 2002
    ....
  45. ncbi Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice
    Alberta Y Hoi
    Department of Medicine, Centre for Inflammatory Diseases, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    J Immunol 177:5687-96. 2006
    ..Taken together, these data suggest MIF as a critical effector of organ injury in SLE...
  46. ncbi Crystal structure of the macrophage migration inhibitory factor from rat liver
    M Suzuki
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Nat Struct Biol 3:259-66. 1996
    ..An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase...
  47. ncbi Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis
    Thierry Calandra
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Infect Dis 187:S385-90. 2003
    ..Given its role in innate immune responses to bacterial infections, MIF is a novel target for therapeutic intervention in patients with septic shock...
  48. ncbi Association of the -173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis
    Hiroaki Nohara
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Gastroenterol 39:242-6. 2004
    ..In the +173 G/C polymorphism of the MIF gene, the presence of C creates the binding motif of activator protein 4. This study explored the association of this polymorphism with ulcerative colitis (UC)...
  49. ncbi A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    R P Donn
    Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
    Arthritis Rheum 44:1782-5. 2001
    ..To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA)...
  50. pmc Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor
    W Y Weiser
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:7522-6. 1989
    ..The availability of the MIF cDNA clone and recombinant MIF will facilitate the analysis of the role of this lymphokine in cell-mediated immunity, immunoregulation, and inflammation...
  51. ncbi Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity
    J B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biochemistry 38:7346-54. 1999
    ..The insertion of an alanine between Pro-1 and Met-2 essentially abolishes activity. Structural studies of these mutants define a source of the reduced activity and provide insight into the mechanism of the catalytic reaction...
  52. pmc Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies
    Xiao bo Zhong
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Nucleic Acids Res 33:e121. 2005
    ..We also present data supporting significant population stratification of the low- versus high-expression forms of MIF that may bear on the role of this gene in infectious diseases...
  53. pmc Macrophage migration inhibitory factor: a central regulator of wound healing
    Matthew J Hardman
    Faculty of Life Sciences, University of Manchester, UK
    Am J Pathol 167:1561-74. 2005
    ....
  54. pmc Increased epithelial and serum expression of macrophage migration inhibitory factor (MIF) in gastric cancer: potential role of MIF in gastric carcinogenesis
    X X He
    Department of Gastroenterology, The Second Affiliated Hospital of Guanzhou Medical College, Guangzhou, China
    Gut 55:797-802. 2006
    ..This study was conducted to determine whether MIF expression is associated with gastric pathology and whether MIF expression is increased in malignant gastric cells in vitro...
  55. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    ..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia...
  56. ncbi Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat
    Eric Houdeau
    Neuro Gastroenterology and Nutrition Unit, Institut National de la Recherche Agronomique, Toulouse, France
    Gastroenterology 132:982-93. 2007
    ..We investigated whether estradiol and progesterone influence MIF, IL-1beta, and TNF-alpha production in experimental colitis...
  57. pmc Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis
    H Murakami
    Third Department of Internal Medicine, Ehime University School of Medicine, Japan
    Clin Exp Immunol 128:504-10. 2002
    ....
  58. ncbi Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease
    Hongqi Lue
    Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart, 70569 Stuttgart, Germany
    Microbes Infect 4:449-60. 2002
    ..Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease...
  59. ncbi Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata
    T Shimizu
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Genes Immun 6:285-9. 2005
    ..MIF is therefore suggested to be closely implicated in the pathogenesis of the more extensive forms of AA...
  60. ncbi Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle
    Alice Nemajerova
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York, USA
    Cell Cycle 6:1030-4. 2007
    ..We discuss the mechanisms by which MIF affects the activity of the ubiquitin-proteasome system, and how this impacts on the integrity of the genome and on cancer...
  61. ncbi Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation
    Oleksi Petrenko
    Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 278:11078-85. 2003
    ..Our results demonstrate that MIF plays a role in an E2F/p53 pathway that operates downstream of Rb regulation and implicate MIF as a mediator of normal and malignant cell growth...
  62. ncbi Macrophage migration inhibitory factor within the alveolar spaces induces changes in the heart during late experimental sepsis
    Xinchun Lin
    Department of Surgery, Institute for Medical Research at North Shore LIJ Health System, Manhasset, New York, NY 11030, USA
    Shock 24:556-63. 2005
    ....
  63. ncbi Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases
    Pascal Renner
    Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Infect Dis 41:S513-9. 2005
    ..Analyses of MIF genotypes in patients with sepsis may help to classify patients into risk categories and to identify those patients who may benefit from anti-MIF therapeutic strategies...
  64. pmc The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors
    Caroline Piette
    Laboratory of Tumor and Developmental Biology, GIGA R, CHU, Liege, Belgium
    J Biol Chem 284:32483-92. 2009
    ..Collectively, our results indicate an intricate pathway between MIF expression and GC resistance. They suggest that MIF inhibitors could increase the response of GBMs to corticotherapy...
  65. pmc Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
    Arlixer M Coleman
    Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 181:2330-7. 2008
    ..This is the first demonstration of a biological role for D-DT, and its synergism with MIF suggests that the combined therapeutic targeting of both family members may enhance current anti-MIF-based therapies...
  66. ncbi Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation
    Elizabeth S Magalhães
    Departamento de Imunologia, Instituto de Microbiologia, UFRJ, Rio de Janeiro, Brazil
    Eur J Immunol 37:1097-106. 2007
    ..The present study demonstrates that MIF is required for allergic inflammation, adding important elements to our knowledge of asthma pathogenesis and suggesting that neutralization of MIF might be of therapeutic value in asthma...
  67. ncbi Macrophage migration inhibitory factor evaluation compared with prostate specific antigen as a biomarker in patients with prostate carcinoma
    Katherine L Meyer-Siegler
    Research and Development, Bay Pines Veterans Administration Medical Center, Bay Pines, Florida 33744, USA
    Cancer 94:1449-56. 2002
    ..The objective of this study was to evaluate the clinical usefulness of serum evaluation of the cytokine macrophage migration inhibitory factor (MIF) in patients undergoing routine prostate specific antigen (PSA) screening...
  68. ncbi Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester, UK
    Genes Immun 4:487-91. 2003
    ..The promoter polymorphisms of MIF, investigated in this study, do not influence the severity of disease outcome by 5 years...
  69. ncbi Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
    Atsuyasu Sato
    Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Antioxid Redox Signal 8:1891-6. 2006
    ..These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking...
  70. ncbi ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis
    Yousef Al-Abed
    Laboratory of Medicinal Chemistry, North Shore Long Island Jewish Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 280:36541-4. 2005
    ....
  71. ncbi Evidence for a role of macrophage migration inhibitory factor in vascular disease
    Zhiping Chen
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arterioscler Thromb Vasc Biol 24:709-14. 2004
    ..However, there is no in vivo evidence that MIF participates directly in vascular injury and repair. Therefore, we investigated the effect of MIF blockade on the response to experimental angioplasty in atherosclerosis-susceptible mice...
  72. ncbi Re-examining the oligomerization state of macrophage migration inhibitory factor (MIF) in solution
    John S Philo
    Alliance Protein Laboratories, 3957 Corte Cancion, Thousand Oaks, CA 91360, USA
    Biophys Chem 108:77-87. 2004
    ..765+/-0.017 ml/g rather than the calculated 0.735 ml/g. With this revised partial specific volume, the equilibrium and velocity data each give M=37.9+/-2.8 kDa, fully consistent with a strongly-associated trimeric quaternary structure...
  73. ncbi Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
    Aoi Son
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Antioxid Redox Signal 11:2595-605. 2009
    ..7 cells. These results suggest that the cell surface TRX serves as one of the MIF binding molecules or MIF receptor component and inhibits MIF-mediated inflammatory signals...
  74. ncbi Cunning factor: macrophage migration inhibitory factor as a redox-regulated target
    Alex Kudrin
    Centre for Molecular Medicine, University of Manchester, Manchester, UK
    Immunol Cell Biol 86:232-8. 2008
    ....
  75. ncbi UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling
    Hélène Hernandez-Pigeon
    INSERM U563, CPTP Centre de Physiopathologie Toulouse Purpan Bat B, Pavillon Lefebvre, Place du Dr Baylac, Centre Hospitalier Universitaire Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    J Biol Chem 282:8157-64. 2007
    ..UV-mediated GrB production may thus have important consequences in photoaging and photocarcinogenesis...
  76. ncbi Postgestational effects of macrophage migration inhibitory factor on embryonic implantation in mice
    Patrick Kibangou Bondza
    Laboratoire d endocrinologie de la reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, Faculte de Medecine, Universite Laval Quebec, QC, Canada
    Fertil Steril 90:1433-43. 2008
    ..To investigate in vivo the effects of macrophage migration inhibitory factor (MIF) on endometrial receptivity and embryonic implantation...
  77. ncbi Expression pattern of macrophage migration inhibitory factor during embryogenesis
    S Kobayashi
    Functional Genomics Unit, Gene Targeting Facility, Bethesda, MD 20892, USA
    Mech Dev 84:153-6. 1999
    ..Here we report a detailed characterization of MIF expression during mouse embryogenesis. The MIF expression pattern was found to parallel tissues specification and organogenesis...
  78. ncbi IL-10 inhibits the synthesis of migration inhibitory factor and migration inhibitory factor-mediated macrophage activation
    J Wu
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    J Immunol 151:4325-32. 1993
    ....
  79. ncbi Macrophage migration inhibitory factor in the human endometrium: expression and localization during the menstrual cycle and early pregnancy
    F Arcuri
    Institute of Pathological Anatomy and Histology and Institute of General Physiology, University of Siena, Siena 53100, Italy
    Biol Reprod 64:1200-5. 2001
    ..The proinflammatory features and specific actions of MIF on lymphoid cells suggest its potential involvement in several aspects of endometrial physiology...
  80. ncbi Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis
    Eric S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Clin Cancer Res 9:853-60. 2003
    ..The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis...
  81. ncbi Identification of macrophage migration inhibitory factor mRNA expression in neural cells of the rat brain by in situ hybridization
    A Ogata
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Neurosci Lett 246:173-7. 1998
    ..These results suggest that MIF plays a pivotal role as an immunomodulatory cytokine for inflammatory reactions and immune responses in the whole central nervous system...
  82. ncbi Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium
    Christian Maaser
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Gastroenterology 122:667-80. 2002
    ..MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators important for regulating mucosal immune and inflammatory responses, we sought to determine if these cells produce MIF...
  83. ncbi MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
    J Bernhagen
    Picower Institute for Medical Research, Manhasset, New York 11030
    Nature 365:756-9. 1993
    ..We conclude that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock...
  84. ncbi Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory diseases
    Richard Bucala
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Drug News Perspect 18:417-26. 2005
    ..In the following review, we discuss recent studies pointing to an important role for the upstream mediator macrophage migration inhibitory factor in the effector responses producing autoimmune tissue damage...
  85. pmc The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
    G Fingerle-Rowson
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 100:9354-9. 2003
    ..The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis...
  86. ncbi Macrophage migration inhibitory factor: a probable link between inflammation and cancer
    Richard Bucala
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 26:281-5. 2007
    ..Here we discuss the current understanding of MIF's role and highlight it as a potential link between inflammatory activation and malignant progression...
  87. pmc CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex
    Xuerong Shi
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:595-606. 2006
    ..These data establish CD44 as an integral member of the CD74 receptor complex leading to MIF signal transduction...
  88. ncbi Macrophage migration inhibitory factor in the human prostate: identification and immunocytochemical localization
    F Arcuri
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Prostate 39:159-65. 1999
    ..The present study was intended to evaluate the expression and tissutal localization of MIF in the human prostate...
  89. ncbi Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
    Alex Kudrin
    Department of Disease Biology, Rheumatology, and Inflammation and Discovery Research, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom
    J Biol Chem 281:29641-51. 2006
    ..The potentiating effect of MIF was seen at physiologically relevant concentrations. These data suggest that MIF has no conventional cytokine activity but, rather, acts to modulate and amplify the response to LPS...
  90. ncbi Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway
    Oleksi Petrenko
    Department of Pathology, Health Science Center, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Mol Cell 17:225-36. 2005
    ..A proinflammatory molecule interfering with tumor suppression and DNA replication provides a compelling molecular link for the association of chronic inflammation and tumorigenesis...
  91. ncbi Macrophage migration inhibitory factor increases MMP-2 activity in DU-145 prostate cells
    K Meyer-Siegler
    Department of Urology, Bay Pines VA Medical Center, FL 33744, USA
    Cytokine 12:914-21. 2000
    ..MIF addition to proliferating DU-145 cells resulted in a two-fold increase in the relative amount of active MMP-2 as determined by zymogram gel analysis of conditioned medium...
  92. ncbi Migration inhibitory factor in the cerebral and systemic endothelium in sepsis and malaria
    Ian Clark
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia
    Crit Care Med 30:S263-7. 2002
    ..We wanted to determine whether it could account for our observation that inducible nitric oxide synthase is less strongly induced in the cerebral, compared with the systemic, vasculature...
  93. ncbi Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration
    Michael Bacher
    Institute of Immunology, Philipps University, Marburg, Germany
    Glia 37:291-306. 2002
    ....
  94. ncbi Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter
    Oliver Flieger
    Institute for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, 70569 Stuttgart, Germany
    FEBS Lett 551:78-86. 2003
    ..Glyburide and probenicide but not other typical inhibitors of non-classical protein export strongly block MIF secretion, indicating that the export pathway of MIF involves an ABCA1 transporter...
  95. pmc Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor
    G Waeber
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 94:4782-7. 1997
    ..MIF is therefore a glucose-dependent, islet cell product that regulates insulin secretion in a positive manner and may play an important role in carbohydrate metabolism...
  96. ncbi Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)
    J Bernhagen
    Picower Institute for Medical Research, Manhasset, New York 11030
    Biochemistry 33:14144-55. 1994
    ..These studies establish the biochemical identity of native and recombinant MIF and provide a first insight into the three-dimensional structural properties of this critical inflammatory mediator...
  97. ncbi Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice
    Tatsuya Ohkawara
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Gastroenterology 123:256-70. 2002
    ....
  98. ncbi Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood
    Sujittra Chaisavaneeyakorn
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia 30341, USA
    J Infect Dis 186:1371-5. 2002
    ..02). Primigravid and secundigravid women had significantly higher levels of MIF in their IVB plasma than did multigravid women (P<.05). HIV infection did not significantly alter MIF levels in any site examined...
  99. ncbi Obesity, macrophage migration inhibitory factor, and weight loss
    T S Church
    The Cooper Institute, 12330 Preston Road, Dallas, TX 75230, USA
    Int J Obes (Lond) 29:675-81. 2005
    ..In this study, we examined the effects of participation in a behavior-based weight loss program on MIF concentrations in obese individuals...
  100. ncbi Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
    M Asif Amin
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 93:321-9. 2003
    ..Our findings support a role for MIF as an angiogenic factor and provide a rationale for the use of MIF as a therapeutic inducer of neovascularization in the development of collateral circulation in coronary artery disease...
  101. ncbi Role of MIF in inflammation and tumorigenesis
    Jan Philipp Bach
    Institute of Immunology, Philipps University Marburg, Marburg, Germany
    Oncology 75:127-33. 2008
    ..This review provides an overview of the involvement of MIF in both autoimmune disorders and tumorigenesis and summarizes the molecular action of MIF in this context...

Research Grants62

  1. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..This work also will enable the identification of individuals who are at risk for severe infection and lethal outcome, so that appropriate measures can be taken to better treat their infections. ..
  2. MIF in progression and treatment of ALD
    Laura E Nagy; Fiscal Year: 2013
    ....
  3. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..We propose to develop novel strategies, directed at these molecules, that may lead to the development of new treatments for patients with coronary artery disease. ..
  4. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..Such inhibitors may show greatest efficacy in those patients with high-expression MIF alleles and who manifest an MIF-dependent form of inflammatory disease. ..
  5. Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal Pathogenesis
    Rituparna Das; Fiscal Year: 2013
    ....
  6. Immunoregulation of Myelin Specific T Lymphocytes
    Arthur A Vandenbark; Fiscal Year: 2013
    ..non-specific (bystander) T-cell specificities. ..
  7. Regulation of Hypoxic Pulmonary Hypertension by MIF
    Todd M Kolb; Fiscal Year: 2012
    ..They may also identify MIF as a bio-marker in patients with PH to monitor progression to RV failure so that treatment strategies can be adjusted accordingly. ..
  8. Corticosteroids for Children with Febrile Urinary Tract Infections
    Nader Shaikh; Fiscal Year: 2013
    ....
  9. Paraventricular nucleus regulatory mechanisms in stress and hypertension
    Colin Sumners; Fiscal Year: 2013
    ..Aim 2 is to determine the role of the TPOR moiety of MIF in mediating the effects of MIF within PVN neurons of SHR and normotensive rats on blood pressure regulation during acute and chronic stress. ..
  10. MIF-Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension
    Edmund J Miller; Fiscal Year: 2013
    ....
  11. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2010
    ..2. To characterize the role of a chronic proinflammatory state in the age-stratified incidence of anemia. 3. To characterize the role of genetic polymorphisms in predicting the development of a proinflammatory state. ..
  12. The role of HIF2alpha in colon carcinogenesis
    Yatrik M Shah; Fiscal Year: 2013
    ..Ultimately these studies will determine if HIF2a is a potential therapeutic target in colon inflammation and may provide an alternative strategy for preventing and treating colon cancer. ..
  13. LPA receptor signaling in colonic epithelia
    CHANGHYON CHRIS YUN; Fiscal Year: 2013
    ....
  14. Molecular characterization of a hookworm Macrophage Migration Inhibitory Factor
    Jon J Vermeire; Fiscal Year: 2010
    ..These studies will allow for the development of new methods aimed at controlling this important human pathogen. ..
  15. The Role of Macrophage Migration Inhibitory Factor in Osteoarthritis
    MEREDITH A GREENE; Fiscal Year: 2013
    ..The results fro these proposed studies examining the role of MIF signaling in the development of OA will significantly impact the field by identifying a novel potential therapeutic target in the treatmen of OA. ..
  16. Safe and Efficacious Oral MIF Inhibitors for Rheumatoid Arthritis Treatment
    ANDERSON GAWECO; Fiscal Year: 2012
    ....
  17. Trichomonas vaginalis MIF: a role in prostate cancer and infertility?
    PATRICIA JEAN JOHNSON; Fiscal Year: 2013
    ..Moreover, this exploratory work sets the stage for continued analyses of TvMIF in T. vaginalis infections in both men and women, as trichomoniasis also increases the risk of cervical cancer and enhances infertility in women. ..
  18. Developing Small MIF Inhibitors for Rheumatoid Arthritis
    Christian Grant; Fiscal Year: 2013
    ..Dose finding studies and PK profiling will first be performed with a preference for oral dosing. An optimized dose and route of administration will then be chosen to test the therapeutic efficacy of two lead compounds in the RA models ..
  19. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2013
    ....
  20. Chemopreventition and treatment of non-melanoma skin cancer by targeting MIF
    Abhay R Satoskar; Fiscal Year: 2013
    ..These data will lay the foundation for a latter RO1 application to develop better and safer MIF antagonists as novel drugs for prevention and treatment of skin cancer. ..
  21. MIF: A novel CNS regulator of cardiovascular function
    Colin Sumners; Fiscal Year: 2013
    ..Information gained from these studies may lead to the development of novel therapeutic targets for hypertension. ..
  22. MIF: a pro-inflammatory cytokine as a novel target to reduce bladder inflammation
    Pedro L Vera; Fiscal Year: 2013
    ....
  23. Amplification of tumor hypoxic responses by MIF-dependent HIF stabilization
    Robert A Mitchell; Fiscal Year: 2013
    ....
  24. Therapeutic Application of Small Molecule MIF Inhibitors in Rheumatoid Arthritis
    Yoonsang Cho; Fiscal Year: 2013
    ..Outcomes of this proposed research will allow us to better understand MIF action to its receptors and also will provide potential drug leads for the treatment of inflammatory diseases. ..
  25. Orchestration of breast cancer osteolytic bone metastasis by MIF
    Jessica M Grunda; Fiscal Year: 2013
    ..Additionally, information gleaned from this work may be used in the generation of therapeutic interventions for other diseases associated with osteoclast-mediated bone loss, such as osteoporosis and diabetes-associated bone disease. ..
  26. Novel treatment strategies to regulate inflammation during P.aeruginosa keratitis
    MIHAELA GUEORGUIEVA GADJEVA; Fiscal Year: 2013
    ..Regulating the activities of these novel therapeutic targets will result in "controlled" inflammatory responses during infection, limit tissue damage, and facilitate an efficient healing process. ..
  27. The Role of MIF in Osteoarthritis
    Richard F Loeser; Fiscal Year: 2013
    ..The elucidation of mechanisms relevant to MIF's role in joint tissue destruction in aim 2 will also be relevant to RA where similar catabolic pathways are active. ..
  28. Molecular Recognition of Proteins and Ligand Design
    William L Jorgensen; Fiscal Year: 2013
    ..Though much work remains to be done to find optimal inhibitors of HIV replication and regulators of MIF signaling, Tdp1 is a promising new target for cancer chemotherapy that is also under investigation. ..
  29. Regulators of Endothelial Cell Apoptosis in LPS-Induced Acute Lung Injury
    Rachel L Damico; Fiscal Year: 2012
    ..These studies will improve our understanding of the factors regulating apoptosis in ALI, information that could lead to new therapies. ..
  30. Development of Ibudilast as a Novel Treatment for Alcoholism
    Lara Ray; Fiscal Year: 2013
    ..Results from this study will inform a subsequent R01 application to conduct a randomized controlled trial of IBUD for alcoholism. ..
  31. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    KAREN G ANTHONY; Fiscal Year: 2013
    ..All of these efforts are expected to yield a lead compound suitable for further development towards a small molecule therapeutic for RA. ..
  32. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Thus we expect that the study will identify the role and mechanisms involved in pulmonary-MIF derived cardiac dysfunction during sepsis and suggest specific strategies to inhibit its production and release from the lung. ..
  33. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. LIPOPROTEINS IN BIOREGULATION OF THE IMMUNE RESPONSE
    Jane Morse; Fiscal Year: 1980
    ..The effects of the lipid and apoprotein components of the plasma lipoproteins will be studied to provide insights into the biochemical mechanisms involved in lipoprotein regulation of the immune response...
  35. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    Karen Anthony; Fiscal Year: 2009
    ..Since MIF acts upstream in the inflammatory cascade in RA, inhibition of this activity will address many of the downstream effector pathways that are ultimately responsible for joint destruction. ..
  36. POR In Inherited Metabolic Liver Diseases
    Pramod Mistry; Fiscal Year: 2009
    ..This training program is supported by Liver T32 DK 07356. ..
  37. HEMOZOIN AND MALARIA PATHOGENESIS
    JAMES MARTINEY; Fiscal Year: 1999
    ..This information will help identify novel approaches to potential therapeutic intervention, develop better diagnostic tools and determine basic pathogenesis and immunology data useful for vaccine development. ..
  38. Potential Role of H. Pylori-induced MIF in Gastric Cancer
    ELLEN BESWICK; Fiscal Year: 2009
    ..The effects of MIF on cell cycle kinetics will be examined. These studies will provide valuable insight into cell signaling and responses that are crucial in both inflammation and the development of gastric cancer. ..
  39. GIF regulation of B cells and CD4 cells
    Katsuji Sugie; Fiscal Year: 2003
    ..This project will fill a critical gap in our knowledge in cytokine biology. ..
  40. MACROPHAGE PROLIFERATION AND ACTIVATION
    John Hadden; Fiscal Year: 1980
    ....
  41. CELLULAR AUTOIMMUNITY IN HUMAN SKIN DISEASE
    DAVID STEINMULLER; Fiscal Year: 1980
    ..The third phase would include clinical correlations of the in vitro assays, with an evaluation of their diagnostic potential and a more detailed basic study of the reactions using purified or fractionated effector cell populations...
  42. REGULATION OF MACROPHAGE MOTILITY BY COMPLEMENT
    Celso Bianco; Fiscal Year: 1980
    ..These experiments may clarify many important aspects of macrophage function and provide more rational concepts for immunotherapy in infections and tumors. ..
  43. INITIATION OF T CELL IMMUNE RESPONSES IN GUT MUCOSA
    Subhash Gautam; Fiscal Year: 1990
    ....
  44. The role of MIF in hookworm infection and disease
    Michael Cappello; Fiscal Year: 2009
    ..These studies will characterize this novel helminth homologue of a multi functional human cytokine, ultimately determining the role of MIF in the pathogenesis of hookworm disease. ..
  45. MOLECULES INVOLVED IN MACROPHAGE RESPONSES TO LYMPHOKINE
    David Liu; Fiscal Year: 1990
    ....
  46. Novel MLCK-MIF Interaction in Endothelium
    Ari Zaiman; Fiscal Year: 2002
    ..Together these studies will define the contribution of the novel interaction between the multifunctional MLCK and a highly relevant cytokine MIF in key endothelial pathologic processes. ..
  47. ASTROCYTES AND MICROGLIA IN EPILEPSY
    Donald Born; Fiscal Year: 2000
    ..Finally the electrophysiology of reactive glial elements in animal epilepsy models and human resected tissue will be studied using patch clamp recording techniques. ..
  48. Migration Inhibitory Factor in the Progression of EAE
    Caroline C Whitacre; Fiscal Year: 2010
    ..This project studies a key factor involved in disease progression and will identify specific points in disease when therapeutic intervention is likely to be successful. ..
  49. Roles of MIF and iNOS in SLE-associate inflammation
    Michael Hickey; Fiscal Year: 2007
    ..Using rMIF, anti-MIF mAb, and anti-MIF small molecules, and by generating MRL/Ipr/MIF -/- mice, we will examine the role of MIF in the modulation of leukocyte-endothelial interactions in murine SLE. [unreadable] [unreadable]..
  50. Alcohol-specific modifications of glycated Hb: Novel biomarkers of alcohol abuse
    Yousef Al Abed; Fiscal Year: 2007
    ..Future studies will be designed to measure these alcohol-specific-markers in humans following binge and chronic alcohol intake. [unreadable] [unreadable] [unreadable]..
  51. EXCITOTOXICITY IN THE HIPPOCAMPUS AFTER VIRAL INFECTION
    Bradley Pearce; Fiscal Year: 2002
    ..These studies aim to provide clues to the mechanisms by which an early viral infection could be involved in certain neurodevelopmental disorders. ..
  52. SDF-1A AND MIP-II INTERACTIONS WITH CHEMOKINE RECEPTORS
    Elias Lolis; Fiscal Year: 2002
    ..The ultimate aim of this work is to use the information generated from these studies in the design of small molecule receptor antagonists for the treatment of HIV-1. ..
  53. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..Moreover, this study opens a new potential direction for therapeutics aimed at depression and obstetric complications. ..
  54. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    ..Besides schizophrenia, these studies could provide insight into Parkinson's disease, and maternal mental illnesses. [unreadable] [unreadable] [unreadable]..
  55. Suppression of Erythropoiesis in Malaria Infection
    Richard Bucala; Fiscal Year: 2008
    ..These results will be significant because they will provide a more precise understanding of the molecular pathways responsible for severe malarial anemia. ..
  56. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ....