hepatocyte growth factor

Summary

Summary: Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.

Top Publications

  1. ncbi Targeting MET in cancer: rationale and progress
    Ermanno Gherardi
    Medical Research Council MRC Centre, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Cancer 12:89-103. 2012
  2. ncbi Met, metastasis, motility and more
    Carmen Birchmeier
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Nat Rev Mol Cell Biol 4:915-25. 2003
  3. pmc Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models
    Lianhua Bai
    Center for Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Nat Neurosci 15:862-70. 2012
  4. ncbi The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    S Whittaker
    Dana Farber Cancer Institute, Boston, MA, USA
    Oncogene 29:4989-5005. 2010
  5. ncbi Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort
    Seiji Yano
    Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Kanazawa, Japan
    J Thorac Oncol 6:2011-7. 2011
  6. ncbi Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    Selma Pennacchietti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Cell 3:347-61. 2003
  7. ncbi Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells
    Reena Buurman
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Gastroenterology 143:811-20.e1-15. 2012
  8. ncbi Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    D P Bottaro
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Science 251:802-4. 1991
  9. ncbi Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis
    Yukihiro Saito
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 114:1177-84. 2006
  10. ncbi Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    Seiji Yano
    Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Cancer Res 68:9479-87. 2008

Research Grants

  1. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
  2. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2012
  3. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
  4. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
  5. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
  6. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
  7. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
  8. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
  9. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
  10. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009

Detail Information

Publications379 found, 100 shown here

  1. ncbi Targeting MET in cancer: rationale and progress
    Ermanno Gherardi
    Medical Research Council MRC Centre, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Cancer 12:89-103. 2012
    ..Genetic and biochemical data have demonstrated that the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, have a causal role in all of these ..
  2. ncbi Met, metastasis, motility and more
    Carmen Birchmeier
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Nat Rev Mol Cell Biol 4:915-25. 2003
  3. pmc Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models
    Lianhua Bai
    Center for Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Nat Neurosci 15:862-70. 2012
    ..Functional assays identified hepatocyte growth factor (HGF) and its primary receptor cMet as critical in MSC-stimulated recovery in EAE, neural cell ..
  4. ncbi The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    S Whittaker
    Dana Farber Cancer Institute, Boston, MA, USA
    Oncogene 29:4989-5005. 2010
    ..target of rapamycin (mTOR) pathway, WNT/beta-catenin pathway, insulin-like growth factor pathway, hepatocyte growth factor/c-MET pathway and growth factor-regulated angiogenic signaling...
  5. ncbi Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort
    Seiji Yano
    Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Kanazawa, Japan
    J Thorac Oncol 6:2011-7. 2011
    This study was performed to determine the incidence rates of resistance factors, i.e., high-level hepatocyte growth factor (HGF) expression, epidermal growth factor receptor (EGFR) T790M secondary mutation, and MET amplification, in ..
  6. ncbi Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    Selma Pennacchietti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Cell 3:347-61. 2003
    ..The Met tyrosine kinase, a high affinity receptor for hepatocyte growth factor (HGF), plays a crucial role in controlling invasive growth and is often overexpressed in cancer...
  7. ncbi Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells
    Reena Buurman
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Gastroenterology 143:811-20.e1-15. 2012
    ..We searched for microRNAs (miRs) that are affected by histone deacetylation and investigated the effects in hepatocellular carcinoma (HCC) cells...
  8. ncbi Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    D P Bottaro
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Science 251:802-4. 1991
    b>Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration...
  9. ncbi Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis
    Yukihiro Saito
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 114:1177-84. 2006
    ..Treatment for this disabling condition remains limited and largely ineffective. The goal of the present study was to investigate the therapeutic efficacy of hepatocyte growth factor (HGF) in animal models of lymphedema.
  10. ncbi Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    Seiji Yano
    Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Cancer Res 68:9479-87. 2008
    ..Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR-..
  11. ncbi Drug development of MET inhibitors: targeting oncogene addiction and expedience
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
    Nat Rev Drug Discov 7:504-16. 2008
    ..Here we discuss recent progress in the development of molecules that inhibit MET function and consider their application in a subset of human tumours that are potentially responsive to MET-targeted therapies...
  12. ncbi Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair
    Lorraine B Ware
    Division of Pulmonary and Critical Care, Department of Medicine, University of California, Los Angeles 90024, USA
    Am J Physiol Lung Cell Mol Physiol 282:L924-40. 2002
    ..growth factors keratinocyte growth factor (KGF), fibroblast growth factor (FGF)-10, and hepatocyte growth factor (HGF) play important roles in lung development, lung inflammation, and repair...
  13. ncbi Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    Livio Trusolino
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    Nat Rev Cancer 2:289-300. 2002
    ..What are the differences between physiological and pathological activation of these signalling molecules, and can we exploit them therapeutically to prevent metastasis?..
  14. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
    ..The specific ligand of the c-met protein, the motility and growth factor scatter factor/hepatocyte growth factor, is expressed in limb mesenchyme and can thus provide the signal for migration which is received by c-met...
  15. ncbi Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases
    Bo Ra Son
    Department of Medicine, University of Alberta, Edmonton, AB T6G 2R8, Canada
    Stem Cells 24:1254-64. 2006
    ..Because stromal-derived factor (SDF)-1 and hepatocyte growth factor (HGF) become up-regulated during tissue/organ damage, in this study we examined whether these factors ..
  16. ncbi Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats
    Magnus Johansson
    Department of Medical Cell Biology, Biomedical Center, Uppsala, Sweden
    Endocrinology 147:2315-24. 2006
    ..endothelial cells from pancreatic islets can stimulate beta-cell proliferation through secretion of hepatocyte growth factor (HGF)...
  17. pmc Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    Chang Goo Huh
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4262, Building 37, Room 4146A, Bethesda, MD 20892 4262, USA
    Proc Natl Acad Sci U S A 101:4477-82. 2004
    b>Hepatocyte growth factor/scatter factor c-met signaling pathway is of central importance during development as well as in tumorigenesis...
  18. ncbi Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells
    Chao Ming Hung
    Department of General Surgery, E Da Hospital, I Shou University, Kaohsiung, Taiwan
    J Agric Food Chem 59:9683-90. 2011
    ..Briefly, our result suggests a connection between FASN activity and c-Met protein expression and that osthole is a potential compound for breast cancer therapy by targeting the major pathway of HGF/c-Met-induced EMT...
  19. pmc Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide
    J E Cartwright
    Department of Biochemistry, St George s Hospital Medical School, Cranmer Terrace, London, SW17 ORE
    Br J Pharmacol 128:181-9. 1999
    1. The expression of hepatocyte growth factor (HGF) is essential for normal placental development although its function is unknown...
  20. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
    ..versus blood vascular endothelial cells (BVEC) revealed that LEC express significantly higher levels of hepatocyte growth factor receptor (HGF-R)...
  21. ncbi Molecular cloning and expression of human hepatocyte growth factor
    T Nakamura
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Nature 342:440-3. 1989
    b>Hepatocyte growth factor (HGF) is the most potent mitogen for mature parenchymal hepatocytes in primary culture, and seems to be a hepatotrophic factor that acts as a trigger for liver regeneration after partial hepatectomy and liver ..
  22. pmc Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
    Stefan Grotegut
    Department of Clinical Biological Sciences, Institute of Biochemistry and Genetics, Center of Biomedicine, University of Basel, Basel, Switzerland
    EMBO J 25:3534-45. 2006
    b>Hepatocyte growth factor/scatter factor (HGF) exerts several functions in physiological and pathological processes, among them the induction of epithelial cell scattering and motility...
  23. ncbi Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
    Y Uehara
    Institute for Liver Research, Kansai Medical University, Moriguchi, Osaka, Japan
    Nature 373:702-5. 1995
    b>Hepatocyte growth factor/scatter factor (HGF/SF) functions as a mitogen, motogen and morphogen for a variety of cultured cells...
  24. ncbi Hepatocyte growth factor twenty years on: Much more than a growth factor
    Takahiro Nakamura
    Cancer Research Institute, Kanazawa University, Kakuma machi, Japan
    J Gastroenterol Hepatol 26:188-202. 2011
    ..1980s, the method for the cultivation of mature hepatocytes provided an opportunity for the discovery of hepatocyte growth factor (HGF) as a protein that is structurally and functionally different from other growth factors...
  25. pmc Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways
    Olorunseun O Ogunwobi
    Department of Pathology, Immunology and Laboratory Medicine and Shands Cancer Center, University of Florida, 1600 SW Archer Road, M651, PO 100275, Gainesville, FL 32610, USA
    Clin Exp Metastasis 28:721-31. 2011
    ..Their morphological characteristics were examined. Expression levels of hepatocyte growth factor (HGF), markers of EMT and mediators of HGF signaling were determined and functional characteristics were ..
  26. pmc Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis
    Shiaw Wei Tyan
    Genomics Research Center, Academia Sinica, Taipei, Taiwan Authority
    PLoS ONE 6:e15313. 2011
    ..The expression level of hepatocyte growth factor (HGF) in these fibroblasts was positively correlated with their ability to enhance breast tumorigenesis ..
  27. pmc Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells
    Richard Buus
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Curr Biol 19:1463-6. 2009
    ..RNA (siRNA) library approach, we have identified 12 DUBs that are necessary for aspects of the hepatocyte growth factor (HGF)-dependent scattering response of A549 cells...
  28. pmc Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma
    Ian J Davis
    Department of Pediatric Oncology, Ludwig Center for Cancer Research, Dana Farber Cancer Institute, Children s Hospital Boston, Boston, Massachusetts, USA
    Cancer Res 70:639-45. 2010
    ..CCS and CCS-derived cell lines express c-Met, which is activated in an autocrine fashion by its ligand hepatocyte growth factor (HGF)/scatter factor in some CCS cell lines...
  29. ncbi The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing
    Kevin Conway
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Wound Repair Regen 14:2-10. 2006
    ..In the process of healing, hepatocyte growth factor, a cytokine known to act as mitogen, motogen, and morphogen, has been postulated to play multiple roles ..
  30. ncbi Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction
    Tobias Deuse
    Departments of Cardiothoracic Surgery, Stanford University, CA 94305 5407, USA
    Circulation 120:S247-54. 2009
    ..Mesenchymal stem cell (MSC)-based regenerative strategies were investigated to treat acute myocardial infarction and improve left ventricular function...
  31. ncbi Effect of hepatocyte growth factor on progression of liver metastasis in colorectal cancer
    Shinji Osada
    Surgical Oncology, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Hepatogastroenterology 57:76-80. 2010
    ..To evaluate therapeutic approaches, the biological responses associated with hepatectomy were studied with a focus on hepatocyte growth factor (HGF).
  32. ncbi Impact of serum hepatocyte growth factor on treatment response to epidermal growth factor receptor tyrosine kinase inhibitors in patients with non-small cell lung adenocarcinoma
    Kazuo Kasahara
    Respiratory Medicine, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 16:4616-24. 2010
    ..However, the responses to EGFR-TKIs vary even among patients with EGFR mutations. We studied several other independently active biomarkers for EGFR-TKI treatment...
  33. pmc Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor
    Ermanno Gherardi
    Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 100:12039-44. 2003
    Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (HGF/SF)...
  34. ncbi Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo
    Lars Tönges
    Department of Neurology, University Medicine Gottingen, R Koch Strasse 40, Gottingen, Germany
    J Neurochem 117:892-903. 2011
    b>Hepatocyte growth factor (HGF) is known to promote the survival and foster neuritic outgrowth of different subpopulations of CNS neurons during development...
  35. ncbi Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
    M Jo
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 275:8806-11. 2000
    ..growth factor alpha (TGFalpha), c-Met is constitutively phosphorylated in the absence of its ligand, hepatocyte growth factor. We proposed that TGFalpha and the autocrine activation of its receptor, epidermal growth factor receptor ..
  36. pmc Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    Pal Kaposi-Novak
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1582-95. 2006
    ....
  37. pmc Met provides essential signals for liver regeneration
    Malgorzata Borowiak
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 101:10608-13. 2004
    ..analysis in mice has demonstrated a crucial role of the Met tyrosine kinase receptor and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver, muscle, and placenta...
  38. ncbi Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
    Joseph Paul Eder
    AstraZeneca LP, Waltham, Massachusetts, USA
    Clin Cancer Res 15:2207-14. 2009
    ..the c-Met signaling pathway due to dysregulation of the c-Met receptor or overexpression of its ligand, hepatocyte growth factor (HGF), has been associated with an aggressive phenotype...
  39. ncbi The MET receptor tyrosine kinase in invasion and metastasis
    Silvia Benvenuti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo Torino, Italy
    J Cell Physiol 213:316-25. 2007
    ..Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its ..
  40. ncbi Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation
    Giancarlo Forte
    Molecular and Cellular Lab, Dipartimento di Medicina Interna, Universita di Roma Tor Vergata, Via Montpellier, 1, 00133 Roma, Italy
    Stem Cells 24:23-33. 2006
    b>Hepatocyte growth factor (HGF), a pleiotropic cytokine of mesenchymal origin promoting migration, proliferation, and survival in a wide spectrum of cells, can also modulate different biological responses in stem cells, but the mechanisms ..
  41. pmc Targeting the HGF/Met signalling pathway in cancer
    Fabiola Cecchi
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States
    Eur J Cancer 46:1260-70. 2010
    Under normal conditions, hepatocyte growth factor (HGF)-induced Met tyrosine kinase (TK) activation is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and ligand activated receptor ..
  42. pmc Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF
    T Nakamura
    Division of Biochemistry, Department of Oncology, Biomedical Research Center B7, Osaka University Graduate School of Medicine, Suita, Japan
    J Clin Invest 106:1511-9. 2000
    ..Supplements of HGF, an endogenous cardioprotective factor, may be found clinically suitable in treating subjects with myocardial infarction...
  43. pmc Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion
    Nikki Cheng
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6838, USA
    Mol Cancer Res 6:1521-33. 2008
    ..in fibroblast-epithelial cell cotransplantation studies in mice, correlating with increased expression of hepatocyte growth factor (HGF)...
  44. ncbi c-Met is a potentially new therapeutic target for treatment of human melanoma
    Neelu Puri
    Departments of Hematology Oncology and Pathology, University of Chicago Medical Center, Chicago, Illinois 60607, USA
    Clin Cancer Res 13:2246-53. 2007
    ..In this study, we investigated the role of c-Met in melanoma biology using a novel small-molecule tyrosine kinase inhibitor SU11274 and small interfering (si) RNA against the receptor...
  45. ncbi The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns
    Jon A Deakin
    Cancer Research UK Glyco Oncology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Rd, Manchester M20 4BX, United Kingdom
    J Biol Chem 284:6311-21. 2009
    Heparan sulfate (HS)/heparin and dermatan sulfate (DS) both bind with high affinity to hepatocyte growth factor/scatter factor (HGF/SF) and function as necessary co-factors in vitro...
  46. ncbi Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions
    N Atabey
    Laboratories of Cellular and Molecular Biology and Medicinal Chemistry, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
    J Biol Chem 276:14308-14. 2001
    b>Hepatocyte growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide range of cellular targets during development, homeostasis and tissue regeneration...
  47. ncbi Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transition
    Keita Okayama
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 59:958-65. 2012
    The purpose of this study was to investigate the effect of hepatocyte growth factor (HGF) on the pathogenesis of cardiac fibrosis induced by pressure overload in mice...
  48. ncbi Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer
    Wei Wang
    Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 18:1663-71. 2012
    b>Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) in EGFR mutant lung cancer cells by activating Met and the downstream phosphoinositide ..
  49. pmc A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism
    Arlee Fafalios
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Med 17:1577-84. 2011
    Met is the transmembrane tyrosine kinase cell surface receptor for hepatocyte growth factor (HGF) and is structurally related to the insulin receptor (INSR) tyrosine kinase...
  50. pmc Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus
    Kathryn P Burdon
    Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 52:8514-9. 2011
    ..Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease...
  51. ncbi Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
    Fawn Qian
    Exelixis, Inc, South San Francisco, California 94083, USA
    Cancer Res 69:8009-16. 2009
    The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), are overexpressed and/or activated in a wide variety of human malignancies...
  52. ncbi Scatter factors and invasive growth
    P M Comoglio
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, Str Provinciale 142, Km 3 95, Candiolo TO, 10060, Italy
    Semin Cancer Biol 11:153-65. 2001
    ..Here we discuss how alterations of these receptors or of their signal transduction pathways are responsible for cancer onset and progression towards metastasis...
  53. ncbi Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene
    Ryuichi Morishita
    Division of Gene Therapy Science, Osaka University Medical School, Osaka, Japan
    Circulation 105:1491-6. 2002
    ..In addition, we examined the feasibility of gene therapy by using an angiogenic growth factor, hepatocyte growth factor (HGF), to treat PAD in the presence of high Lp(a).
  54. pmc HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop
    Zanobia A Syed
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and Feist Weiller Cancer Center, Shreveport, Louisiana 71103, USA
    BMC Cancer 11:180. 2011
    ..The hepatocyte growth factor (HGF)/c-met receptor tyrosine kinase signaling pathway is responsible for stimulation of cell motility ..
  55. ncbi X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling
    Hiroya Takeuchi
    Department of Molecular Oncology, Gastrointestinal Section, Santa Monica, CA 90404, USA
    Clin Cancer Res 11:7621-8. 2005
    ..We hypothesized that the hepatocyte growth factor (HGF) activation in colorectal cancer via c-Met receptor regulates IAP proteins through Akt signaling.
  56. ncbi Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors
    Idris Tolgay Ocal
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cancer 97:1841-8. 2003
    ..Although RTKs are a large family, HER-2, epidermal growth factor receptor (EGFR), Met (hepatocyte growth factor receptor), and others all have shown the ability to predict outcome...
  57. ncbi Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines
    Chu Sheng-Hua
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University College of Medicine, Shanghai 201900, ROC China
    Surg Neurol 68:610-3; discussion 613-4. 2007
    ..The scope of this study is to investigate HGF secretion by malignant glioma cells with different radiosensitivity after irradiation...
  58. ncbi Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion
    Jingwei Shang
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatacho, Okayama, Japan
    J Neurosci Res 89:86-95. 2011
    b>Hepatocyte growth factor (HGF) and glial cell line-derived neurotrophic factor (GDNF) are strong neurotrophic factors. However, their potentials in neurogenesis, angiogenesis, synaptogenesis, and antifibrosis have not been compared...
  59. pmc Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
    B Cao
    Van Andel Research Institute, 333 Bostwick, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 98:7443-8. 2001
    The hepatocyte growth factor (HGF/SF) receptor, Met, regulates mitogenesis, motility, and morphogenesis in a cell type-dependent fashion...
  60. ncbi Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: role of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase
    Hong Y Zhou
    University of Hong Kong, School of Biological Sciences, 4S 14 Kadoorie Biological Sciences Building, Hong Kong
    Endocrinology 148:5195-208. 2007
    ..Epidermal growth factor (EGF) and hepatocyte growth factor (HGF) are often both overexpressed and contribute to the growth of ovarian cancer by activating autocrine ..
  61. ncbi Hepatocyte growth factor, its receptor, and their potential value in cancer therapies
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Crit Rev Oncol Hematol 53:35-69. 2005
    b>Hepatocyte growth factor plays multiple roles in cancer, by acting as a motility and invasion stimulating factor, promoting metastasis and tumour growth. Furthermore, it acts as a powerful angiogenic factor...
  62. ncbi A cell-intrinsic role for Mst1 in regulating thymocyte egress
    Yongli Dong
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    J Immunol 183:3865-72. 2009
    ..T lineage-specific knockout of the Mst1 gene demonstrates a cell-intrinsic role for Mst1 in regulating T cell development. Our study indicates that Mst1 is crucial in controlling lymphocyte chemotaxis and thymocyte emigration...
  63. ncbi Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal
    Camille Nicoleau
    Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique, Poitiers, France
    Stem Cells 27:408-19. 2009
    ..a growth-stimulatory activity of liver explant-conditioned media on SVZ cell cultures and identify hepatocyte growth factor (HGF) as a major player in this effect...
  64. pmc Regulation of neuronal cell death by MST1-FOXO1 signaling
    Zengqiang Yuan
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:11285-92. 2009
    ..Collectively, these findings define MST1-FOXO1 signaling as an important link survival factor deprivation-induced neuronal cell death with implications for our understanding of brain development and neurological diseases...
  65. ncbi Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    Satdarshan P S Monga
    Division of Cellular and Molecular Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 62:2064-71. 2002
    b>Hepatocyte growth factor (HGF) and Wnt signaling pathways have been shown to be important in embryogenesis and carcinogenesis. The aim of this study was to elucidate the mechanism of functional similarities observed in the two pathways...
  66. ncbi Hepatocyte growth factor in myeloma patients treated with high-dose chemotherapy
    Carina Seidel
    Department of IMPI, Division of Pathology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Br J Haematol 119:672-6. 2002
    b>Hepatocyte growth factor (HGF) is a cytokine produced by myeloma cells. We examined serum HGF levels in a population of young myeloma patients (median age 52 years) treated with high-dose chemotherapy...
  67. ncbi Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
    L Nguyen
    Department of Medicine, Molecular Oncology Group, Royal Victoria Hospital, McGill University, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    J Biol Chem 272:20811-9. 1997
    b>Hepatocyte growth factor/scatter factor is a multifunctional factor that induces mitogenesis, motility, invasion, and branching tubulogenesis of several epithelial and endothelial cell lines in culture...
  68. ncbi Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga University Faculty of Medicine, Saga, B49 8501 Japan
    Cancer Sci 99:1341-7. 2008
    Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form...
  69. ncbi Annexin A3 expression increases in hepatocytes and is regulated by hepatocyte growth factor in rat liver regeneration
    Mizuho Harashima
    Department of Nutrition and Physiology, Nihon University College of Bioresource Sciences, Kameino Fujisawa, Japan
    J Biochem 143:537-45. 2008
    ..AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level...
  70. ncbi Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer
    Tadaaki Yamada
    Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    Clin Cancer Res 16:174-83. 2010
    ..We showed previously that hepatocyte growth factor (HGF) induced gefitinib resistance of lung cancer harboring EGFR-activating mutations...
  71. ncbi HGF/SF-met signaling in the control of branching morphogenesis and invasion
    Yu wen Zhang
    Laboratory of Molecular Oncology, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, Michigan 49503, USA
    J Cell Biochem 88:408-17. 2003
    b>Hepatocyte growth factor/Scatter factor (HGF/SF) is a multifunctional growth factor which can induce diverse biological events. In vitro, these include scattering, invasion, proliferation and branching morphogenesis...
  72. ncbi Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition
    Gautam Maulik
    Department of Medicine, Division of Adult Oncology, Lowe Center for Thoracic Oncology, Binney Street, Boston, MA 02115, USA
    Cytokine Growth Factor Rev 13:41-59. 2002
    ..Stimulation of c-Met via its ligand hepatocyte growth factor also known as scatter factor (HGF/SF), leads to a plethora of biological and biochemical effects in the ..
  73. ncbi Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
    Wei Wang
    Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 15:6630-8. 2009
    ..We have therefore assessed the effect of crosstalk between stromal cells and lung cancer cells harboring EGFR mutations on susceptibility to EGFR-TKIs...
  74. ncbi Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
    Koko Katagiri
    Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Osaka 570 8506, Japan
    Nat Immunol 7:919-28. 2006
    ..Our study demonstrates a previously unknown function for Mst1 of relaying the Rap1-RAPL signal to induce cell polarity and adhesion of lymphocytes...
  75. pmc Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction
    Monika Kwiecinski
    Institute for Pathology, University Hospital Cologne, Cologne, Germany
    PLoS ONE 6:e24568. 2011
    ..In contrast, hepatocyte growth factor (HGF), exerts antifibrotic activities. Recently, miR-29 has been reported to be involved in ECM synthesis...
  76. ncbi Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transition in hepatocellular carcinoma
    Tomoyuki Nagai
    Kazuto Nishio, Department of Genome Biology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Mol Cancer Ther 10:169-77. 2011
    ..Here, we examined the effect of sorafenib on the EMT. Hepatocyte growth factor (HGF) induced EMT-like morphologic changes and the upregulation of SNAI1 and N-cadherin expression...
  77. ncbi Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor
    Hai Feng Duan
    Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, 100850, Beijing, People s Republic of China
    Mol Ther 8:467-74. 2003
    ..b>Hepatocyte growth factor, a recognized angiogenic factor and endothelial cell chemoattractant, has been applied in the treatment ..
  78. ncbi C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu
    Ernst Lengyel
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Mail Code 2050, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Int J Cancer 113:678-82. 2005
    ..40), we evaluated expression of the c-Met and Her2/neu receptor tyrosine kinases and the c-Met ligand hepatocyte growth factor/scatter factor (HGF/SF) in primary breast cancers and their lymph node metastases using both conventional ..
  79. ncbi A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    L Trusolino
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Torino, Candiolo, Italy
    Cell 107:643-54. 2001
    ..Such findings invoke an unexpected role for alpha6beta4 in cancer invasion as a functional amplifier of biochemical outputs rather than a mechanical adhesive device...
  80. pmc Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
    Dominic P Del Re
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103 2714, USA
    J Clin Invest 120:3555-67. 2010
    ....
  81. ncbi Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Int J Cancer 125:1657-62. 2009
    We previously reported that a combination of serum hepatocyte growth factor (HGF) and carcinoembryonic antigen (CEA) was useful for selecting early-stage colorectal cancer patients with aggressive disease...
  82. pmc Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling
    Myrto Giannopoulou
    Department of Pathology, University of PittsburghSchool of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 173:30-41. 2008
    ..Here, we show that hepatocyte growth factor (HGF) inhibited renal inflammation and proinflammatory chemokine expression by disrupting nuclear factor (..
  83. ncbi Co-expression of hepatocyte growth factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-Met signaling in gastric cancer
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan
    Int J Cancer 130:2912-21. 2012
    ..EMT is induced by factors such as hepatocyte growth factor (HGF)...
  84. ncbi Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
    Shinji Osada
    Department of Surgical Oncology, Gifu University School of Medicine, Gifu City, Japan
    Hepatogastroenterology 55:544-9. 2008
    To develop a prognostic marker for evaluation of intrahepatic metastasis (IM) of hepatocellular carcinoma (HCC), the ligand-stimulated receptor activity of c-Met due to hepatocyte growth factor (HGF) was estimated.
  85. ncbi Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease
    Y Taniyama
    Department of Geriatric Medicine, Biomedical Research Center, Osaka University Medical School, Japan
    Gene Ther 8:181-9. 2001
    b>Hepatocyte growth factor (HGF) exclusively stimulates the growth of endothelial cells without replication of vascular smooth muscle cells, and acts as a survival factor against endothelial cell death...
  86. ncbi Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential beta-catenin phosphorylation
    Monica D David
    Laboratori d Investigacio, Hospital Universitari Arnau de Vilanova, Departament de Ciencies Mediques Basiques, Universitat de Lleida, IRBLLEIDA, Spain
    J Cell Sci 121:2718-30. 2008
    ..is required for axon growth downstream of brain-derived neurotrophic factor (BDNF) signalling and hepatocyte growth factor (HGF) signalling...
  87. ncbi NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor
    Wenlin Du
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Blood 109:3042-9. 2007
    b>Hepatocyte growth factor (HGF) promotes cell growth and motility and also increases neovascularization...
  88. ncbi The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction
    Emil Ruvinov
    Avram and Stella Goldstein Goren Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    Biomaterials 32:565-78. 2011
    ..We hypothesized that the dual delivery of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) by injectable affinity-binding alginate biomaterial would maximize their therapeutic effects, ..
  89. ncbi Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells
    Mao Ye
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Invest Ophthalmol Vis Sci 49:497-504. 2008
    ..This study investigated the effect of hepatocyte growth factor (HGF)-triggered signaling pathways to identify the role of HGF and its downstream effectors in inducing ..
  90. ncbi Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death
    Marie Wislez
    Service de Pneumologie et de Reanimation Respiratoire, AP HP, Hopital Tenon, 75020 Paris
    Cancer Res 63:1405-12. 2003
    ..b>Hepatocyte growth factor (HGF) is a pleiotropic cytokine operating through activation of the proto-oncogene c-met and is a factor ..
  91. ncbi Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin
    Hsiang Yu Chang
    Graduate Institute of Life Sciences, National Defense Medical Center and Academia Sinica, Taipei, Taiwan
    J Agric Food Chem 59:5357-63. 2011
    Substantial activation of the hepatocyte growth factor (HGF)/c-Met pathway leads to cancer cell scattering and invasion and has been observed in several types of cancers, including prostate and colorectal cancers...
  92. pmc c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74
    Maya Gordin
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 185:2020-31. 2010
    ..In this study, we describe a novel biological mechanism involved in mature B cell homeostasis, the hepatocyte growth factor/scatter factor (HGF)/c-Met pathway...
  93. ncbi Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer
    Roy Akira Saito
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:2644-54. 2010
    ..fibroblasts revealed that FoxF1 regulates the contractility of fibroblasts, their production of hepatocyte growth factor and fibroblast growth factor-2, and their stimulation of lung cancer cell migration...
  94. ncbi Treatment of avascular necrosis of the femoral head by hepatocyte growth factor-transgenic bone marrow stromal stem cells
    Q Wen
    Institute of Molecular Immunology, Southern Medical University, Guangzhou, People s Republic of China
    Gene Ther 15:1523-35. 2008
    ..of hormone-induced early-stage avascular necrosis of the femoral head (ANFH) with transplantation of hepatocyte growth factor (HGF)-transgenic bone marrow stromal stem cells (BMSCs) was examined...
  95. ncbi Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma
    L Pour
    Department of Internal Medicine Hematooncology, University Hospital Brno, Masaryk University Brno Czech Republic
    Neoplasma 57:29-34. 2010
    ..Patients with low angiogenesis rate as determined by the relative HGF and TSP-1 concentrations were more likely to achieve complete or very good partial response after high-dose chemotherapy...
  96. ncbi Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells
    Eric Sulpice
    Institut des Vaisseaux et du Sang, INSERM U965, Universite Paris 7, Hopital Lariboisiere, Paris, France
    Biol Cell 101:525-39. 2009
    ..HGF (hepatocyte growth factor) is a pleiotropic cytokine that may promote VEGF-A-driven angiogenesis, although the signalling ..
  97. ncbi Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma
    C Y Hsia
    Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Eur J Surg Oncol 33:208-12. 2007
    ..Previous reports indicated that HCC was also associated with increased levels of interleukin (IL)-6, IL-10 and hepatocyte growth factor (HGF). This study investigated the role of these cytokines as tumor markers for HCC.
  98. ncbi Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF
    Chunsun Dai
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Sttreet, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 15:1402-12. 2004
    ..For understanding the potential mechanism by which hepatocyte growth factor (HGF) ameliorates diabetic nephropathy, the effects of HGF on mesangial cell activation induced by TGF-..
  99. ncbi Expression of hepatocyte growth factor and its receptor c-met in the ovine uterus
    C Chen
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1844-50. 2000
    ..The objective of this study was to determine if hepatocyte growth factor (HGF, scatter factor) and its receptor c-met were present in the ovine uterus and to characterize their ..
  100. pmc Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
    Shu yi Chen
    Department of Life Science and Graduate Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan
    Mol Cell Biol 26:5155-67. 2006
    ..Here we report that FAK directly interacts with the hepatocyte growth factor receptor c-Met...
  101. ncbi Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property
    Daiki Miura
    Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo, Japan
    Clin Exp Metastasis 21:445-51. 2004
    ..in vivo metabolite(s) suppress the invasion, we estimated intracellular peroxide level and expression of hepatocyte growth factor (HGF), a known cell motility factor, in AH109A cells...

Research Grants74

  1. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
    ..Am 3 will study hepatocyte growth factor (HGF) regulation of CYP7A1 gene transcription to identify signaling pathway and crosstalk with insulin ..
  2. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..Examine SAMe's regulation of HGF-mediated hepatocyte proliferation. Hepatocyte growth factor (HGF) activates AMP kinase (AMPK), which is required for hepatocyte proliferation...
  3. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..data show that the PAH PAEC secrete the potent growth- stimulatory &bone marrow-mobilizing hepatocyte growth factor (HGF)...
  4. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..hepatic irradiation and mitotic stimulation by a single injection of an adenovector, expressing hepatocyte growth factor to induce repopulation of the liver with the transplanted hepatocytes...
  5. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Recent studies suggest that hepatocyte growth factor (HGF), a pleiotropic cytokine, has multiple activities that lead to lung regeneration...
  6. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..48 hours from admission to measure the 5 biomarkers (tumor necrosis factor-a receptor-1, interleukin-8, hepatocyte growth factor, angiopoietin-2, resistin) using Luminex technology...
  7. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..b>Hepatocyte growth factor (HGF) increases 2-cell proliferation and promotes revascularization of islets, while interleukin-1 ..
  8. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..b>Hepatocyte growth factor (HGF), also known as scatter factor (CF), is a renotrophic growth factor that exerts tissue protective ..
  9. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    ..data, we further hypothesize that the effects of VEGF on lung structure are dependent upon stimulation of hepatocyte growth factor and enhanced retinoic acid production by vascular endothelium ("angiocrine factors")...
  10. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..Significant evidence suggests that scatter factor / hepatocyte growth factor (SF/HGF), exerts direct hepatoprotective effects and can potentially be used as a therapeutic in ALF...
  11. Function and Structure Adaptations in Forebrain Development
    PAT R LEVITT; Fiscal Year: 2013
    ..MET and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and maturation of neuronal circuits in vitro...
  12. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatocyte growth factor (HGF) is a pleiotropic cytokine that promotes cell proliferation, motility, survival, and morphogenesis...
  13. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..include tumor necrosis factor (TNF)-??and interleukin (IL)-6, which are produced by Kupffer cells, and hepatocyte growth factor (HGF), which is produced primarily by stellate cells...
  14. Aberrant activation of HGF/MET signaling as a therapeutic target in AML
    Alex Kentsis; Fiscal Year: 2013
    ..I discovered that shRNA mediated depletion of hepatocyte growth factor (HGF), ligand of the receptor tyrosine kinase MET, specifically inhibits growth of AML but not other ..
  15. The role of cMET in satellite cells during muscle regeneration
    MICAH TAUBE WEBSTER; Fiscal Year: 2013
    ..c-Met encodes a receptor tyrosine kinase. Activation by its ligand, Hepatocyte Growth Factor (HGF), triggers multiple signaling cascades that modulate cell survival, proliferation, and migration of ..
  16. Network modeling of epithelial mesenchymal transition in liver cancer metastasis
    Steven N Steinway; Fiscal Year: 2013
    ..Recently, we have demonstrated that Hepatocyte Growth Factor (HGF) is a primary initiator of EMT in multiple liver cancer models...
  17. Regulation of hepcidin and iron metabolism in liver disease
    Julia Goodnough; Fiscal Year: 2011
    ..Candidates for the suppressor of hepcidin include hepatocyte growth factor (HGF) and growth and differentiation factor 15 (GDF15)...
  18. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
    ..data indicate that, in hepatocytes, the insulin receptor (IR) tyrosine kinase crosstalks with the Hepatocyte Growth Factor Receptor (HGFR) tyrosine kinase (also known as Met) through intermolecular tyrosine phosphorylation...
  19. Ron Receptor Tyrosine Kinase Signaling in Breast Cancer
    Susan E Waltz; Fiscal Year: 2013
    ..However, the degree of dependency of the Ron ligand, hepatocyte growth factor-like protein (HGFL), in this model remains unknown...
  20. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..c-Met, also known as the hepatocyte growth factor receptor, is a receptor tyrosine kinase that regulates cell proliferation, differentiation, migration and ..
  21. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    ..advantage to transplanted hepatocytes, using preparative hepatic X-irradiation (HIR) and expressing hepatocyte growth factor (HGF) as a mitotic stimulant...
  22. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ..epidermal growth factor (EGF), CTGF, insulin-like growth factor-2 (IGF-II), interleukin-1 (IL-1), hepatocyte growth factor (HGF), and Wnt ligands...
  23. Microtubule-associated Rac
    Anna Birukova; Fiscal Year: 2013
    ..Our novel data show that MT-mediated signaling is directly involved in the EC barrier preservation by hepatocyte growth factor (HGF), a circulating molecule with proven protective effects in the models of acute ling injury (ALI)...
  24. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Other factors may play important roles during this process including the hepatocyte growth factor (HGF) which has received little attention in terms of its function in ocular angiogenesis...
  25. Human Osteoprogenitor Control by Hepatocyte Growth Factor and Vitamin D
    Guy Howard; Fiscal Year: 2013
    ..proposed studies on human mesenchymal stem cell (MSC) differentiation and maturation catalyzed by hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D (1,25OHD), the most active metabolite of vitamin D...
  26. Bridging Pediatric and Adult Biomarkers of Graft-Versus-Host-Disease
    Jamie L Renbarger; Fiscal Year: 2013
    ..adult population [interleukin-2- receptor-alpha, tumor-necrosis-factor-receptor-1, interleukin-8, hepatocyte growth factor, elafin, a skin-specific marker, regenerating islet-derived 3-alpha, a gastro-intestinal specific marker, ..
  27. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..apoptosis by activating the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway, and (d) hepatocyte growth factor (HGF), a growth factor with pleiotropic effects on tumor growth...
  28. Micromagnetic Aptamer PCR System for Ultrasensitive Multiplexed Protein Detection
    HYONGSOK TOM SOH; Fiscal Year: 2010
    ..will demonstrate simultaneous detection of three cancer markers, platelet derived growth factor (PDGF), hepatocyte growth factor (HGF), and thyroid transcription factor (TTF1), at femtomolar concentration levels directly from serum...
  29. CYTOSKELETAL REGULATION OF LUNG ENDOTHELIAL PATHOBIOLOGY
    Joe G N Garcia; Fiscal Year: 2012
    ..of signaling to the actomyosin cytoskeleton evoked when c-Met, a tyrosine kinase receptor, is ligated by hepatocyte growth factor, a major barrier-regulatory pathway with strong potential for receptor transactivation...
  30. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..protease zymogens, including urokinase plasminogen activator (uPA) and prostasin, and also activates pro-hepatocyte growth factor (HGF), which serves as a ligand for c-met, a receptor tyrosine kinase involved in gastrointestinal repair...
  31. Hepatocyte Growth Factor and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have previously shown that hepatocyte growth factor (HGF) has beneficial effects in beta cell proliferation, function and islet transplantation...
  32. Mechanisms of Deregulation of Matriptase in Breast Cancer
    Chen Yong Lin; Fiscal Year: 2013
    ..We have shown that in these tissues, Hepatocyte Growth factor Activator Inhibitor-1 (HAI-1), a kunitz-type protease inhibitor, is required for the normal regulation of ..
  33. The Role of Hepatocyte Growth Factor Signaling Airspace Homeostasis
    Enid R Neptune; Fiscal Year: 2011
    ..If successful, these studies will provide an extensive therapeutic armamentarium to support regenerative alveolarization for a wide range of pulmonary disorders. ..
  34. Simltaneous recruitment of cardiac and bone marrow stem cells for cardiac repair
    Khawaja H Haider; Fiscal Year: 2012
    ..We anticipate that transplantation of Sca-1+ cells genetically modified to overexpress hepatocyte growth factor (HGF), stromal cell derived factor-11 (SDF-11) and insulin-like growth factor (IGF-1) will develop ..
  35. A Pilot Clinical Study in Acute STEMI
    Weizhong Cai; Fiscal Year: 2011
    ..Scatter factor / hepatocyte growth factor (SF/HGF) is an endogenous cell survival factor that exerts both acute and chronic cardioprotective ..
  36. Molecular Mechanism of Hepatocyte Growth Factor Signaling
    Po Han Chen; Fiscal Year: 2013
    ..The overall goal of the proposal is to elucidate the molecular basis of recognition/activation between hepatocyte growth factor (HGF) and its receptor MET receptor tyrosine kinase (MET RTK)...
  37. delta-Catenin and Cell-Cell Adhesion in Prostate Cancer
    Qun Lu; Fiscal Year: 2010
    ..Specific Aim 1 will determine how 8-catenin promotes cell growth/survival and motility in response to the hepatocyte growth factor and/or androgen using CWR22 tumor xenografts and their derived cell lines...
  38. The role of c-Met expression in melanoma growth and migration
    AMBER LEIGH SHADA; Fiscal Year: 2010
    ..c-Met and its ligand, hepatocyte growth factor (HGF), may be upregulated in metastatic melanoma and are implicated in invasion and clinical disease ..
  39. Molecular and Genetic Determinants of invasion in HNSCC
    Cun Yu Wang; Fiscal Year: 2013
    ..During the last funding period, we have demonstrated that hepatocyte growth factor (HGF)/c-Met inhibits anoikis induced by a loss of cell-matrix interaction and promotes SCC progression...
  40. Genetic Control of Ureter and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..We therefore investigate the roles of several candidates, including fibroblast growth factors (FGFs) and hepatocyte growth factor (HGF), in these processes...
  41. Novel Neuroprotective/Restorative Therapy for Ischemic Stroke
    David E Smith; Fiscal Year: 2012
    ..b>Hepatocyte growth factor (HGF) a neurotrophic factor, reduces cerebral infarct size, augments cerebral blood flow and promotes ..
  42. HGF Signaling in Kidney Repair
    Lloyd G Cantley; Fiscal Year: 2012
    ..b>Hepatocyte growth factor is highly upregulated following acute tubular injury and has been shown in vitro to stimulate cell ..
  43. Identification of vascular inductive signals in liver regeneration
    Shahin Rafii; Fiscal Year: 2013
    ..kinase receptor (VEGFR2) and Id1 pathway in LSECs upregulated the angiocrine expression of Wnt2 and hepatocyte growth factor (HGF) stimulating hepatic proliferation...
  44. Unique Clinical Study on DGF Using Paired Kidneys
    Weizhong Cai; Fiscal Year: 2012
    ..Angion Biomedica is developing BB3, a small molecule hepatocyte growth factor mimetic that exhibits significant tissue protective activity in numerous models of acute renal injury...
  45. Bombesin-Activated Carcinoma Associated Fibroblasts in Colorectal Cancer
    Celia Chao; Fiscal Year: 2013
    ..activation of the MEK/ERK pathway, regulation of COX-2 promoter activity and upregulation of Hepatocyte Growth Factor in CAFs...
  46. Cellular repair in acute kidney injury
    Lisa M Curtis; Fiscal Year: 2013
    ..the applicant in the process used to study signaling pathways, particularly as applied to the study of hepatocyte growth factor (HGF) and stromal cell-derived factor 1 (SDF-1) , two known modulators of the pathophysiology of cellular ..
  47. Studies on the Post-translational processing of MUC1
    Michael A Hollingsworth; Fiscal Year: 2012
    ..In contrast to the results with PDGF-BB, stimulation of pancreatic tumor cells with hepatocyte growth factor (HGF) under conditions of MUC1 overexpression decreases cell invasive through a mechanism in which MUC1 ..
  48. Engineered HGF-NK1 antagonists for Met-targeted cancer imaging and therapy
    Jennifer R Cochran; Fiscal Year: 2013
    ..agents we used the N- terminal and first Kringle domain (NK1) of the natural Met activating ligand, hepatocyte growth factor (HGF), as a basis for engineering potent Met receptor antagonists...
  49. Targeting RON Receptor Signaling in Pancreatic Cancer
    Andrew M Lowy; Fiscal Year: 2010
    ..We have shown that activation of RON receptor signaling by its specific ligand, hepatocyte growth factor-like protein (HGFL), induces apoptotic resistance, migration, invasion, association with EGFR, and VEGF ..
  50. Phase I Clinical Trial for BB3
    Weizhong Cai; Fiscal Year: 2009
    ..b>Hepatocyte growth factor (HGF), also know as scatter factor (SF), is an endogenous cell survival factor that exerts ..
  51. Safety and efficacy of optimized AAV3 vectors in murine and NHP livers
    Arun Srivastava; Fiscal Year: 2013
    ..AAV3 vectors also transduce primary human hepatocytes efficiently, as they utilize human hepatocyte growth factor receptor (HGFR) as a cellular co-receptor...
  52. Development of Small Molecule Mimetics of hepatocyte Growth Factor (HGF)
    ANNE MUESCH; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The naturally-occurring cytokine hepatocyte growth factor (HGF), also known as scatter factor(SF), is active in numerous tissues throughout the body, participating in the regulation of angiogenesis, ..
  53. A Novel Hybrid Multifunctional Cytokine for Immune Reconstitution
    Susan C Wright; Fiscal Year: 2012
    ..The fusokine, termed Ha7, consists of IL-7 linked to a peptide derived from the alpha chain of hepatocyte growth factor (HGF)...
  54. Oncolytic HSV Therapy in Immunocompetent Sarcoma Models
    Timothy P Cripe; Fiscal Year: 2010
    ..Here we will exploit a remarkable new mouse model, transgenic for hepatocyte growth factor/scatter factor (HGF/SF-tg) and null for the tumor suppressor locus p16 -INK4A/ARF, to investigate lytic ..
  55. Mechanisms of Met Induced Hepatocytes Survival
    Reza Zarnegar; Fiscal Year: 2013
    ..The Hepatocyte Growth Factor Receptor (HGFR) known as Met is a transmembrane receptor tyrosine kinase (RTK) that plays an important ..
  56. Osteogenic Maturation and Bone Repair Require 1,25- and 24,25-dihydroxyvitamin D
    KEVIN MATTHEW CURTIS; Fiscal Year: 2012
    ..factor p63 is required for skeletal formation, and our recent work demonstrated that p63 is integral for hepatocyte growth factor (HGF) and 1,25OHD induced VDR expression and osteogenic maturation...
  57. Designing Fibrin Microthread Scaffolds for Skeletal Muscle Regeneration
    Jonathan M Grasman; Fiscal Year: 2013
    ..with precisely tuned degradation properties and conjugated with wound healing growth factors such as hepatocyte growth factor (HGF) and insulin-like growth factor (IGF)-I, will enhance skeletal muscle regeneration of a large muscle ..
  58. Transcriptional profiling of 2.5 dimensional MDCK tubulogenesis
    KENNETH KWON; Fiscal Year: 2010
    ..5D, that allows efficient MDCK tubulogenesis. Compared to hepatocyte growth factor-induced three-dimensional tubulogenesis, a common model system for investigation of in vitro ..
  59. The Role of ESCRT in Macrophage Resistance to Mycobacteria
    Jennifer A Philips; Fiscal Year: 2013
    ..tb protein, EsxH, and the host protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), which is a component of the ESCRT machinery...
  60. Cytohesin dependent ARF to Rac signaling in HGF mediated motility
    Lorraine C Santy; Fiscal Year: 2013
    ..b>Hepatocyte growth factor (HGF) promotes the recovery from kidney damage at multiple steps...
  61. Secreted Wnt Inhibitors in the Biology of Osteosarcoma
    Bang H Hoang; Fiscal Year: 2010
    ..pro-invasive pathways in OS: (1) Transcriptional repressors Slug and Twist, (2) MMP-2 and 9, and (3) the hepatocyte growth factor receptor Met...
  62. Evaluation of MSP Antagonists for the Treatment of Pancreatic Cancer
    Joseph W Harding; Fiscal Year: 2013
    ..over activation of two growth factor systems macrophage stimulating protein(MSP)/RON (its receptor) and hepatocyte growth factor(HGF)/c- Met(its receptor) as critical contributors to pancreatic cancer's ability to disseminate ..
  63. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..data show that the PAH PAEC secrete the potent growth- stimulatory &bone marrow-mobilizing hepatocyte growth factor (HGF)...
  64. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..In addition to P, these responses require mammary stroma derived-hepatocyte growth factor (HGF)...
  65. CELL-CELL INTERACTIONS IN TESTIS DEVELOPMENT
    Michael Skinner; Fiscal Year: 2007
    ..g. hepatocyte growth factor) to promote seminiferous cord formation from aggregates of Sertoli and primordial germ cells, and that ..
  66. Mechanism of Host Cell Invasion by Microbial Pathogens
    Partho Ghosh; Fiscal Year: 2010
    ..InIB acts by binding and activating the host cell receptor tyrosine kinase Met (also called hepatocyte growth factor receptor, HGFR), thereby inducing signaling pathways that lead to actin-dependent uptake of the bacterium...
  67. Anti-Fibrotic Therapy for Pulmonary Fibrosis
    Latha Paka; Fiscal Year: 2007
    ..Recent studies have identified hepatocyte growth factor (HGF) as an antifibrogenic agent that protects against transforming growth factor (TGFbeta) mediated ..
  68. MOLECULAR REGUL OF HUMAN COLON CANCER LIVER METASTASIS
    Robert Radinsky; Fiscal Year: 1999
    ..Four specific aims will be pursued. EGF-R, hepatocyte growth factor (c- met), and insulin-like growth factor-1 receptor (IGF-1-R) will be functionally characterized (alone ..
  69. IMPROVED METHODS FOR IN VIVO HEPATIC GENE THERAPY
    KATHERINE PONDER; Fiscal Year: 2006
    ..We have demonstrated during the previous funding period that hepatocyte growth factor (HGF) can efficiently induce hepatocyte replication in rodents...
  70. HGF Gene Transcription and Function in the Liver
    Reza Zarnegar; Fiscal Year: 2006
    ..S, and hepatic stellate cells (HSC-i.e. lipocytes) are important effectors of liver fibrosis. Hepatocyte growth factor (HGF), a mitogen for hepatocytes and an inhibitor of liver fibrosis, is a secreted polypeptide whose gene ..
  71. Signaling for cardioprotection against oxidative stress
    Yuichiro Suzuki; Fiscal Year: 2006
    ..of this application is to evaluate specifically the role of GATA-4 in cell survival signaling induced by hepatocyte growth factor and endothelin-l...
  72. Chemoprevention of Gliomas using Nitrones with Anti-c-Met Activity
    Rheal Towner; Fiscal Year: 2009
    ..Our hypothesis is that c-Met, a tyrosine kinase receptor for the hepatocyte growth factor (scatter factor) plays an integral role in the formation of malignant gliomas, and that altered c-Met ..
  73. REGULATION OF PAI I AND LIVER PATHOLOGY IN THE AGED
    CAROLYN BRUZDZINSKI; Fiscal Year: 1999
    ..The two primary mediators of HCG, hepatocyte growth factor (HCG) and transforming growth factor type beta (TGF-beta), can regulate PAI-1 gene expression in certain ..
  74. BIOCHEMISTRY OF UTERINE HEPARAN SULFATE RECEPTORS
    Daniel Carson; Fiscal Year: 2006
    ..HS-binding proteins include growth factors such as heparin-binding, EGF-like growth factor (HB-EGF), hepatocyte growth factor (HGF) and fibroblast growth factor-2 (FGF-2) as well as HS/heparin interacting protein (HIP/L29), a ..