bone morphogenetic proteins

Summary

Summary: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Top Publications

  1. ncbi Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells
    Hue H Luu
    Molecular Oncology Laboratory, Department of Surgery, 5841 South Maryland Avenue, MC 3079, Room J 611, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Orthop Res 25:665-77. 2007
  2. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
  3. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
  4. ncbi Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
    K Yamaguchi
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Science 270:2008-11. 1995
  5. ncbi Developmental regulation of the growth plate
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nature 423:332-6. 2003
  6. pmc TGF-β and BMP signaling in osteoblast differentiation and bone formation
    Guiqian Chen
    Institute of Genetics, Life Science College, Zhejiang University, 388 Yuhang Road, Hangzhou 310058, China
    Int J Biol Sci 8:272-88. 2012
  7. doi The specificities of small molecule inhibitors of the TGFß and BMP pathways
    Janis Vogt
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    Cell Signal 23:1831-42. 2011
  8. doi Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    Desmond Padhi
    Amgen Inc, Thousand Oaks, CA, USA
    J Bone Miner Res 26:19-26. 2011
  9. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
  10. ncbi Balancing BMP signaling through integrated inputs into the Smad1 linker
    Gopal Sapkota
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 25:441-54. 2007

Detail Information

Publications426 found, 100 shown here

  1. ncbi Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells
    Hue H Luu
    Molecular Oncology Laboratory, Department of Surgery, 5841 South Maryland Avenue, MC 3079, Room J 611, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Orthop Res 25:665-77. 2007
    ..b>Bone morphogenetic proteins (BMPs) can regulate the differentiation of mesenchymal stem cells into cartilage, bone, tendon/ligament,..
  2. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    b>Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily...
  3. ncbi Novel regulators of bone formation: molecular clones and activities
    J M Wozney
    Tissue Growth and Repair Program, Genetics Institute, Inc, Cambridge, MA 02140
    Science 242:1528-34. 1988
    ..Two of the encoded proteins (BMP-2A and BMP-3) are new members of the TGF-beta supergene family, while the third, BMP-1, appears to be a novel regulatory molecule...
  4. ncbi Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
    K Yamaguchi
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Science 270:2008-11. 1995
    ..Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members...
  5. ncbi Developmental regulation of the growth plate
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nature 423:332-6. 2003
    ..The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development...
  6. pmc TGF-β and BMP signaling in osteoblast differentiation and bone formation
    Guiqian Chen
    Institute of Genetics, Life Science College, Zhejiang University, 388 Yuhang Road, Hangzhou 310058, China
    Int J Biol Sci 8:272-88. 2012
    ..This review also highlights the different modes of cross-talk between TGF-β/BMP signaling and the signaling pathways of MAPK, Wnt, Hedgehog, Notch, and FGF in osteoblast differentiation and bone formation...
  7. doi The specificities of small molecule inhibitors of the TGFß and BMP pathways
    Janis Vogt
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    Cell Signal 23:1831-42. 2011
    ..Our observations have highlighted the need for caution when using these small molecule inhibitors to assess the physiological roles of BMP and TGFß pathways...
  8. doi Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    Desmond Padhi
    Amgen Inc, Thousand Oaks, CA, USA
    J Bone Miner Res 26:19-26. 2011
    ....
  9. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
    b>Bone morphogenetic proteins (BMPs) play crucial roles in craniofacial development but little is known about their interactions with other signals, such as Endothelin 1 (Edn1) and Jagged/Notch, which pattern the dorsal-ventral (DV) axis ..
  10. ncbi Balancing BMP signaling through integrated inputs into the Smad1 linker
    Gopal Sapkota
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 25:441-54. 2007
    ..The interplay between linker phosphorylation, Smurf-dependent ubiquitination, and nucleoporin exclusion enables regulation of BMP action by diverse signals and biological contexts...
  11. ncbi Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:531-9. 2006
    ..Our data suggest a mechanism by which HFE2 mutations cause hemochromatosis: hemojuvelin dysfunction decreases BMP signaling, thereby lowering hepcidin expression...
  12. ncbi BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    Michael Zeisberg
    Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 9:964-8. 2003
    ..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease...
  13. doi Recent advances in BMP receptor signaling
    Christina Sieber
    Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Germany
    Cytokine Growth Factor Rev 20:343-55. 2009
    b>Bone Morphogenetic Proteins (BMPs) play an important role during organ development and during regeneration after tissue damage. BMPs signal via transmembrane serine/threonine kinase receptors...
  14. ncbi Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    Xiaofeng Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, 06030, USA
    J Biol Chem 280:19883-7. 2005
    ....
  15. ncbi SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    Mikhail Semenov
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26770-5. 2005
    ..Our findings suggest that SOST is an antagonist for Wnt signaling and that the loss of SOST function likely leads to the hyperactivation of Wnt signaling that underlies bone overgrowth seen in sclerosteosis patients...
  16. ncbi Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    Olexander Korchynskyi
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 277:4883-91. 2002
    Transforming growth factor-beta (TGF-beta) family members, which include bone morphogenetic proteins (BMPs) and TGF-betas, elicit their cellular effects by activating specific Smad proteins, which control the transcription of target ..
  17. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
    ....
  18. ncbi Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
    ..Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis...
  19. ncbi Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician?
    Nikitas Sykaras
    Department of Fixed Prosthodontics, Dental School, Athens University, Athens, Greece
    J Oral Sci 45:57-73. 2003
    b>Bone Morphogenetic Proteins (BMPs) form a unique group of proteins within the Transforming Growth Factor beta (TGF-beta) superfamily of genes and have pivotal roles in the regulation of bone induction, maintenance and repair...
  20. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
    ..In contrast, we find that the loss of both BMP2 and BMP4 results in a severe impairment of osteogenesis...
  21. pmc Dorsal-ventral patterning and neural induction in Xenopus embryos
    Edward M De Robertis
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Annu Rev Cell Dev Biol 20:285-308. 2004
    ..Many of the molecular players that regulate D-V patterning via regulation of BMP signaling have been conserved between Drosophila and the vertebrates...
  22. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
    b>Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of developmental processes, but their functions during early vertebrate brain development are largely unknown...
  23. ncbi Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    S G M Piccirillo
    Department of Biotechnology and Biosciences, University of Milan Bicocca, 20126 Milan, Italy
    Nature 444:761-5. 2006
    ..Here we report that bone morphogenetic proteins (BMPs), amongst which BMP4 elicits the strongest effect, trigger a significant reduction in the stem-..
  24. ncbi Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells
    Ying Peng
    Molecular Oncology Laboratory, Department of Surgery, and Committe on Genetics, University of Chicago, IL 60637, USA
    J Biol Chem 279:32941-9. 2004
    b>Bone morphogenetic proteins (BMPs) belong to the TGF-beta superfamily and play an important role in development and in many cellular processes...
  25. doi Roles of TGF-beta family signaling in stem cell renewal and differentiation
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Res 19:103-15. 2009
    Transforming growth factor (TGF)-betas and their family members, including bone morphogenetic proteins (BMPs), Nodal and activins, have been implicated in the development and maintenance of various organs, in which stem cells play ..
  26. pmc Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    Luis C Fuentealba
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Cell 131:980-93. 2007
    ..Epistatic experiments suggested that the dorsoventral (BMP) and anteroposterior (Wnt/GSK3) patterning gradients are integrated at the level of Smad1 phosphorylations during embryonic pattern formation...
  27. ncbi Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    H Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Development 122:2977-86. 1996
    ..These defects are consistent with the expression of Bmp2 in the extraembryonic mesoderm cells and promyocardium. Thus BMP2 is a critical factor for both extraembryonic and embryonic development...
  28. ncbi Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
    Zunyi Zhang
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 129:4135-46. 2002
    ..Our findings provide insights into the cellular and molecular etiology of the non-syndromic clefting associated with Msx1 mutations...
  29. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    ..These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass...
  30. pmc Links between signal transduction, transcription and adhesion in epithelial bud development
    Colin Jamora
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nature 422:317-22. 2003
    ....
  31. ncbi Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients
    Shunmugam Govender
    Department of Orthopaedics, 4th Floor, University of Natal, 719 Umbilo Road, Durban, South Africa
    J Bone Joint Surg Am 84:2123-34. 2002
    ....
  32. ncbi Silencing of TGF-beta signalling by the pseudoreceptor BAMBI
    D Onichtchouk
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 401:480-5. 1999
    Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation...
  33. ncbi SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    Gareth J Inman
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    Mol Pharmacol 62:65-74. 2002
    ..It has no effect on the other, more divergent ALK family members that recognize bone morphogenetic proteins (BMPs)...
  34. ncbi Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells
    Qing Luo
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 279:55958-68. 2004
    ..Both bone morphogenetic proteins (BMPs) and Wnt signaling are implicated in regulating osteoblast differentiation and bone formation...
  35. doi Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    Chuwen Lin
    Bio X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    J Bone Miner Res 24:1651-61. 2009
    ..Our findings also indicated sclerostin is a promising target for preventing disuse osteoporosis...
  36. pmc FGF signalling inhibits neural induction in human embryonic stem cells
    Boris Greber
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Munster, Germany
    EMBO J 30:4874-84. 2011
    ..Our study assigns a novel, biphasic role to FGF/ERK signalling in the neural induction of hESCs, which may also have utility for applications requiring the rapid and efficient generation of peripheral neurons...
  37. ncbi Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation
    Alexander Rosendahl
    AstraZeneca R and D Lund, Department of Molecular and Biosciences, Lund, Sweden
    Am J Respir Cell Mol Biol 27:160-9. 2002
    b>Bone morphogenetic proteins (BMPs) are pleiotropic secreted proteins, structurally related to transforming growth factor (TGF)-beta and activins...
  38. pmc Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    A Hata
    Cell Biology Program, Howard Hughes Medical Institute and The Sloan Kettering Division of the Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 12:186-97. 1998
    ..Smad6 specifically competes with Smad4 for binding to receptor-activated Smad1, yielding an apparently inactive Smad1-Smad6 complex. Therefore, Smad6 selectively antagonizes BMP-activated Smad1 by acting as a Smad4 decoy...
  39. doi Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 23:860-9. 2008
    ..Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone...
  40. ncbi Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    Kenneth E S Poole
    MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    FASEB J 19:1842-4. 2005
    ..In doing so, sclerostin may act as a key inhibitory signal governing skeletal microarchitecture...
  41. doi Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 24:578-88. 2009
    ....
  42. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
  43. pmc Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    Jodie L Babitt
    Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Invest 117:1933-9. 2007
    ..These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease...
  44. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..Thus, we show here that Fgf10 serves as an essential regulator of lung and limb formation...
  45. ncbi Id proteins in development, cell cycle and cancer
    Marianna B Ruzinova
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 241, New York, NY 10021, USA
    Trends Cell Biol 13:410-8. 2003
    ..Thus, the Id proteins have become important molecules for understanding basic biological processes as well as targets for potential therapeutic intervention in human disease...
  46. ncbi BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  47. pmc Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling
    Krzysztof Kobielak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:10063-8. 2007
    ..Conversely, sustained BMP signaling in the SC niche blocks activation and promotes premature hair follicle differentiation. Together, these studies reveal the importance of balancing BMP signaling in the SC niche...
  48. pmc Applications of small molecule BMP inhibitors in physiology and disease
    Charles C Hong
    Division of Cardiovascular Medicine and Center for Inherited Heart Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
    Cytokine Growth Factor Rev 20:409-18. 2009
    b>Bone morphogenetic proteins (BMPs) provide critical signals for determining cell fate, specifying gastrulation, embryonic patterning, organogenesis, and the remodeling of diverse tissues...
  49. ncbi A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    H Zhu
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook 11794 5215, USA
    Nature 400:687-93. 1999
    ..Smurf1 also enhances cellular responsiveness to the Smad2 (activin/TGF-beta) pathway. Thus, targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals...
  50. ncbi BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
    G Luo
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:2808-20. 1995
    b>Bone morphogenetic proteins (BMPs) are multifunctional growth factors originally identified by their ability to induce ectopic bone formation...
  51. ncbi A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    A T Dudley
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 9:2795-807. 1995
    ..Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development...
  52. doi Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Nat Rev Mol Cell Biol 10:91-103. 2009
    ..Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning...
  53. ncbi Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery
    Q Kang
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Gene Ther 11:1312-20. 2004
    ..Although several bone morphogenetic proteins (BMPs) (mostly BMP-2 and BMP-7) have been shown to induce bone formation, it is unclear whether the ..
  54. ncbi BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    Qi Long Ying
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, EH9 3JQ, Edinburgh, Scotland
    Cell 115:281-92. 2003
    ..Here, we report that bone morphogenetic proteins (BMPs) act in combination with LIF to sustain self-renewal and preserve multilineage differentiation, ..
  55. ncbi Neural induction: old problem, new findings, yet more questions
    Claudio D Stern
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:2007-21. 2005
    ..This review summarizes neural induction events in different species and highlights some unanswered questions about this important developmental process...
  56. pmc Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth
    Roselyne Castonguay
    Acceleron Pharma, Cambridge, Massachusetts 02139, USA
    J Biol Chem 286:30034-46. 2011
    ..We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in surface plasmon resonance (Biacore) and cell-based assays...
  57. ncbi Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells
    Guozhi Xiao
    Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Bone Miner Res 17:101-10. 2002
    ..secrete a complex extracellular matrix (ECM) containing collagenous and noncollagenous proteins, bone morphogenetic proteins (BMPs), and growth factors...
  58. ncbi Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling
    Lesley Gerrard
    Department of Gene Function and Development, Roslin Institute, Roslin, Midlothian, EH25 9PS, UK
    Stem Cells 23:1234-41. 2005
    ..Our findings will provide a platform for studying the molecular mechanism controlling neural differentiation...
  59. ncbi Delivering on the promise of bone morphogenetic proteins
    R H Li
    Genetics Institute, 1 Burtt Road, 01810, Andover, MA, USA
    Trends Biotechnol 19:255-65. 2001
    ..b>Bone morphogenetic proteins (BMPs) are an important class of bone growth factors and will be the focus of this article...
  60. pmc Neogenin, a receptor for bone morphogenetic proteins
    Meiko Hagihara
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:5157-65. 2011
    b>Bone morphogenetic proteins (BMPs) regulate many mammalian physiologic and pathophysiologic processes. These proteins bind with the kinase receptors BMPR-I and BMPR-II, thereby activating Smad transcription factor...
  61. ncbi Multiple effects of GDF-5 deficiency on skeletal tissues: implications for therapeutic bioengineering
    Borjana Mikic
    Picker Engineering Program, Smith College, Northampton, MA 01063, USA
    Ann Biomed Eng 32:466-76. 2004
    ....
  62. pmc Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
    Si Tuen Lee-Hoeflich
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    EMBO J 23:4792-801. 2004
    ....
  63. pmc Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    Elizabeth Zuniga
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 138:5147-56. 2011
    ....
  64. pmc Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    Qi Qun Tang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:9607-11. 2004
    ..We interpret the findings as evidence that BMP4 is capable of triggering commitment of pluripotent C3H10T1/2 stem cells to the adipocyte lineage...
  65. pmc Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    Jaroslav Truksa
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:10289-93. 2006
    Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4...
  66. pmc Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish
    Ross F Collery
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Dev Dyn 240:712-22. 2011
    ..Overall, these lines will serve as valuable tools to explore the mechanisms and regulation of BMP signal during embryogenesis, in tissue maintenance, and during disease...
  67. pmc Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
    David G Winkler
    Department of Gene Function and Target Validation, Celltech R and D, Inc, Bothell, WA 98021, USA
    EMBO J 22:6267-76. 2003
    ..Modulation of this osteocyte-derived negative signal is therapeutically relevant for disorders associated with bone loss...
  68. doi Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss
    Agostino Gaudio
    Department of Internal Medicine, University of Catania, 95124 Catania, Italy
    J Clin Endocrinol Metab 95:2248-53. 2010
    ..Sclerostin, a Wnt signaling antagonist on the osteoblasts produced by osteocytes, is regulated by mechanical strain and is implicated in the pathogenesis of disuse bone loss. There are no data on sclerostin in humans...
  69. ncbi Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 131:1353-64. 2004
    ..Thus, niche signals directly repress differentiation-promoting genes in stem cells in order to maintain stem cell self-renewal...
  70. pmc Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery
    Gavin B Bishop
    Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA, 02118, USA
    Int Orthop 31:721-7. 2007
    ..has inductive properties for the development of bone and cartilage, there are now 15 individual human bone morphogenetic proteins (BMPs) that possess varying degrees of inductive activities...
  71. doi Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
    P C Bessa
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    J Tissue Eng Regen Med 2:81-96. 2008
    b>Bone morphogenetic proteins (BMPs) are cytokines with a strong effect on bone and cartilage growth and with important roles during embryonic patterning and early skeletal formation...
  72. ncbi Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
    Laurent David
    Institut National de la Sante et de la Recherche Medicale INSERM, Equipe Mixte INSERM EMI 01 05, Grenoble, France
    Blood 109:1953-61. 2007
    ..Taken together, our results suggest that BMP9 and BMP10 are two specific ALK1 ligands that may physiologically trigger the effects of ALK1 on angiogenesis...
  73. ncbi Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)
    Hongwei Cheng
    Department of Surgery, The University of Chicago Medical Center, Illinois, USA
    J Bone Joint Surg Am 85:1544-52. 2003
    ..The optimal BMPs to be used in different clinical applications have not been elucidated, and a comprehensive evaluation of the relative osteogenic activity of different BMPs is lacking...
  74. ncbi Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner
    S M Galloway
    AgResearch Molecular Biology Unit, and Centre for Gene Research, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Nat Genet 25:279-83. 2000
    ..These findings establish that BMP15 is essential for female fertility and that natural mutations in an ovary-derived factor can cause both increased ovulation rate and infertility phenotypes in a dosage-sensitive manner...
  75. ncbi BMP signalling in craniofacial development
    Xuguang Nie
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009 Bergen, Norway
    Int J Dev Biol 50:511-21. 2006
    ..BMP signalling is also an important participant for tooth development, regulating early tooth morphogenesis and subsequent odontoblast differentiation. In this review these aspects are discussed in detail with a focus on recent advances...
  76. ncbi Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis
    S Bellusci
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Development 122:1693-702. 1996
    ..A model is proposed for the role of BMP4 and other signalling molecules in embryonic lung morphogenesis...
  77. pmc In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors
    Jijun Hao
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    ACS Chem Biol 5:245-53. 2010
    ....
  78. pmc Noggin expands neural stem cells in the adult hippocampus
    Michael A Bonaguidi
    Davee Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 28:9194-204. 2008
    ..Thus, we propose that the adult hippocampus contains a population of NSCs, which can be expanded both in vitro and in vivo by blocking BMP signaling...
  79. pmc Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation
    Zheng Zhou
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Dev Cell 19:90-102. 2010
    ..Taken together, our results indicate that neogenin promotes chondrogenesis in vitro and in vivo, revealing an unexpected mechanism underlying neogenin regulation of BMP signaling...
  80. ncbi Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase
    George P Sorescu
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Circ Res 95:773-9. 2004
    ..Together, these results suggest that BMP4 produced in ECs by OS stimulates ROS release from the nox1-dependent NADPH oxidase leading to inflammation, a critical early atherogenic step...
  81. ncbi Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways
    Gopal Sapkota
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 281:40412-9. 2006
    ....
  82. ncbi BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    Marion Scharpfenecker
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Sci 120:964-72. 2007
    ..Taken together, these results suggest that BMP-9 is a physiological ALK1 ligand that plays an important role in the regulation of angiogenesis...
  83. pmc Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
    Gregory D Cuny
    Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 18:4388-92. 2008
    ..g., plasma t(1/2)=1.6h) following intraperitoneal administration in mice. These studies provide useful molecular probes for examining the in vivo pharmacology of BMP signaling inhibition...
  84. ncbi Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily
    N P Barbara
    Cancer and Blood Research Program, Toronto M5G 1X8, Ontario, Canada
    J Biol Chem 274:584-94. 1999
    ..Our data suggest that endoglin is an accessory protein of multiple kinase receptor complexes of the TGF-beta superfamily...
  85. ncbi Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage
    Arnaud A Mailleux
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Development 132:2157-66. 2005
    ..We provide support for a role of epithelial BMP4 in mediating the formation of parabronchial smooth muscle cells...
  86. pmc BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis
    K Nakashima
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
    Proc Natl Acad Sci U S A 98:5868-73. 2001
    ....
  87. ncbi Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
    N W Morrell
    Department of Medicine, University of Cambridge, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circulation 104:790-5. 2001
    ..We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members...
  88. pmc NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
    Go Kuratomi
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Biochem J 386:461-70. 2005
    ....
  89. doi Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells
    Dilek Colak
    Helmhotz Center Munich, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 28:434-46. 2008
    ..Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis...
  90. doi Emerging role of bone morphogenetic proteins in angiogenesis
    Laurent David
    Institut National de la Sante et de la Recherche Medicale, U878, 17 rue des Martyrs, 38054 Grenoble, France
    Cytokine Growth Factor Rev 20:203-12. 2009
    b>Bone morphogenetic proteins (BMPs) are multifunctional growth factors belonging to the transforming growth factor beta (TGFbeta) superfamily...
  91. ncbi LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
    Mikhail V Semenov
    Neurobiology Program, Children s Hospital Boston, 61 Binmney Street, Boston, MA 02115, USA
    J Biol Chem 281:38276-84. 2006
    ....
  92. ncbi The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    L B Zimmerman
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720, USA
    Cell 86:599-606. 1996
    ..Neural induction and mesoderm dorsalization are antagonized by bone morphogenetic proteins (BMPs), which induce epidermis and ventral mesoderm instead...
  93. pmc Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions
    G E Friedlaender
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    J Bone Joint Surg Am 83:S151-8. 2001
    The role of bone morphogenetic proteins (BMPs) in osseous repair has been demonstrated in numerous animal models...
  94. pmc Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
    Rutger L van Bezooijen
    Department of Endocrinology, C4 R, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Netherlands
    J Exp Med 199:805-14. 2004
    ..Its unique localization and action on osteoblasts suggest that sclerostin may be the previously proposed osteocyte-derived factor that is transported to osteoblasts at the bone surface and inhibits bone formation...
  95. ncbi Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  96. ncbi GDF11 controls the timing of progenitor cell competence in developing retina
    Joon Kim
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Science 308:1927-30. 2005
    ..Thus, GDF11 governs the temporal windows during which multipotent progenitors retain competence to produce distinct neural progeny...
  97. ncbi wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila
    Hermann Aberle
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 33:545-58. 2002
    ..The NMJ phenotype is specifically rescued by transgenic expression of Wit only in motoneurons. Thus, Wit appears to function as a presynaptic receptor that regulates synaptic size at the Drosophila NMJ...
  98. doi Bone morphogenetic proteins: a critical review
    Beth Bragdon
    Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA
    Cell Signal 23:609-20. 2011
    b>Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the Transforming Growth Factor Beta superfamily...
  99. ncbi Autoregulation of neurogenesis by GDF11
    Hsiao Huei Wu
    Department of Anatomy and Neurobiology and the Developmental Biology Center, University of California, Irvine, Irvine, CA 92697, USA
    Neuron 37:197-207. 2003
    ..This negative autoregulatory action of GDF11 is strikingly like that of its homolog, GDF8/myostatin, in skeletal muscle, suggesting that similar strategies establish and maintain proper cell number during neural and muscular development...
  100. ncbi De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
    Anna Pavlina G Haramis
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 303:1684-6. 2004
    ..Many JP cases are known to harbor mutations in BMP pathway genes. These data indicate that intestinal BMP signaling represses de novo crypt formation and polyp growth...
  101. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    ..Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion...

Research Grants75

  1. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..of autograft and allograft bone, distraction osteogenesis, and the application of recombinant, human bone morphogenetic proteins (BMPs). Each of these has considerable drawbacks...
  2. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..We will also determine how the native bone protein spp24 (secreted phosphoprotein-24 kDa) inhibits BMP/TGF-b-dependent tumor cell growth. ..
  3. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
    ..These studies may provide the basis for novel therapeutic approaches to inflammatory bowel disease and CAC. ..
  4. BMP signaling in vertebrate development
    Ken W Y Cho; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone morphogenetic proteins (BMPs) are members of the TGF[unreadable] superfamily of secreted signaling molecules...
  5. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..b>Bone morphogenetic proteins (BMPs), the largest subset in the transforming growth factor 2 (TGF2) superfamily of cytokines, play a ..
  6. Mechanisms of Astrocyte Development
    Teri L Belecky Adams; Fiscal Year: 2010
    ..my laboratory is to understand the mechanisms by which certain growth and patterning factors, such as bone morphogenetic proteins (BMPs) and sonic hedgehog (SHH), direct differentiation and gene expression in normal and reactive ..
  7. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..The bone morphogenetic proteins (BMPs) are used as therapeutic measures for promoting bone regeneration...
  8. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Targ
    Yan Zhang; Fiscal Year: 2013
    ..technical skills through investigations into the roles of retinal pigment epithelium (RPE) and bone morphogenetic proteins (BMPs) in eye growth regulation and myopia development, with the RPE targeted in related exploratory ..
  9. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ....
  10. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..mediators, as well as tissue remodeling cytokines, such as fibroblast growth factors (FGF), bone morphogenetic proteins (BMP), vascular endothelial growth factor (VEGF), etc...
  11. The role of the Wnt/planar cell polarity pathway in pulmonary angiogenesis
    Vinicio A de Jesus Perez; Fiscal Year: 2013
    ....
  12. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2013
    ..growth factor 2 (TGF2) superfamily, the largest family of secreted proteins in mammals, includes the bone morphogenetic proteins (BMPs), actives, and myostatin...
  13. Role of Bone Morphogenetic Protein 4 in Hypoxic Pulmomary Hypertension
    Jian Wang; Fiscal Year: 2013
    ..b>Bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-2 (TGF-2) superfamily, are known as critical ..
  14. Heparan Sulfate Proteoglycans in Human Hematopoiesis
    Pankaj Gupta; Fiscal Year: 2013
    ..vitro, wherein HS co-localize and modulate the activity of cytokines, chemokines, morphogens (including bone morphogenetic proteins: BMPs) and matrix components on HSC...
  15. The Molecular Genetics of Early Neurogenesis
    Ethan Bier; Fiscal Year: 2013
    ..stem cells to assume sensory or neural crest fates under the control of local inductive signals such as Bone morphogenetic proteins (BMPs)...
  16. BMP2 signaling of the development of osetoarthritis
    Vicki Rosen; Fiscal Year: 2013
    ..The role of bone morphogenetic proteins (BMPs), in the pathogenesis of OA remains controversial despite many years of study...
  17. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
    ..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
  18. BMP7 and the regulation of central and peripheral energy balance
    Kristy Townsend; Fiscal Year: 2012
    ..The bone morphogenetic proteins (BMPs) are growth factors, and recent studies have demonstrated roles for the BMPs in metabolism and ..
  19. Sp7 Mediated Control of Runx2 Function for Osteoblast Differentiation
    Amjad Javed; Fiscal Year: 2013
    ..At first, secreted morphogens such as bone morphogenetic proteins, hedgehog, wingless proteins and others, signal to key transcription factors to specify gene expression...
  20. DEVELOPMENT OF MAMMALIAN OOCYTE-GRANULOSA CELL COMPLEX
    John J Eppig; Fiscal Year: 2012
    ..Resolution of these mechanisms of intercellular signaling will lead to novel clinical solutions to female infertility. ..
  21. Role of Angiogenesis in Distraction Osteogenesis
    LOUIS CHARLES GERSTENFELD; Fiscal Year: 2013
    ..The completion of Aims 1 and 2 will determine if ECs are a primary cell source of BMP2 in regulating skeletal healing after surgery or injury and if BMP2 has a functional role in vasculogenesis. ..
  22. Regulation of Iron Homeostasis by BMP Signaling
    Jodie L Babitt; Fiscal Year: 2013
    ..It is hoped that this work may lead to new therapeutic strategies for treating disorders of iron metabolism such as anemia of chronic disease and hemochromatosis. ..
  23. Structure of sclerostin protein complexes
    Rajiv Kumar; Fiscal Year: 2012
    ..This effort will greatly help women and men with osteoporosis and osteoporosis-related fractures. ..
  24. Manipulation of Follicular Helper T Cells in Immunity and Autoimmunity
    Joseph Craft; Fiscal Year: 2013
    ..To accomplish this goal, we will take advantage of our recent observation that ectodin, an inhibitor of bone morphogenetic proteins (BMPs), is selectively expressed by Tfh cells among other immune cells...
  25. NORADRENERGIC SYSTEM IN DEPRESSION
    GREGORY ALLEN ORDWAY; Fiscal Year: 2012
    ..Understanding the molecular pathology of this disorder holds the promise of identifying new biological targets for the development of improved treatments. ..
  26. ACE2 as a target for pulmonary hypertension therapeutics
    MOHAN K contact RAIZADA; Fiscal Year: 2010
    ..Our objective in this investigation is to use genetically modified hematopoietic stem cells to deliver ACE2 or Ang-(1-7) to the site of pulmonary injury to orchestrate a robust pulmonary vascular repair and reverse PH. ..
  27. ANALYSIS OF REPRODUCTIVE FUNCTION USING TRANSGENIC MICE
    Martin M Matzuk; Fiscal Year: 2013
    ....
  28. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  29. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Metabolism
    Yu Hua Tseng; Fiscal Year: 2013
    ....
  30. BMP2 Gene Regulation in Calcific Aortic Valve Disease
    Melissa B Rogers; Fiscal Year: 2013
    ..End of Abstract) ..
  31. LPS binding to TLR4 regulates hepatic stellate cell activation and fibrosis
    Ekihiro Seki; Fiscal Year: 2013
    ..The results from this study might establish TLR4 and its related functions as targets for the therapy of hepatic fibrosis. ..
  32. Taste organs: formation and regulation
    Hongxiang Liu; Fiscal Year: 2013
    ..Wnt1-Cre driven, conditional genetic modifications of type I receptors Alk2 and Alk3 for bone morphogenetic proteins (BMPs) significantly alter the tongue, taste papilla and taste bud formation and maintenance in a level-..
  33. The Roles of Fat3 and Atrophin-2 in Jaw-Joint Development in Zebrafish
    Pierre Le Pabic; Fiscal Year: 2013
    ..Most of the techniques employed under this award will be learned by the candidate under the supervision of his sponsor, and will prepare him for a career as a Principal Investigator in the field of developmental biology. ..
  34. BMP-2 Regulation of Bone Homeostasis
    Vicki Rosen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone morphogenetic proteins (BMPs) were identified as potent bone forming agents based on their ability to induce de novo bone formation in adult animals and this unique feature of BMP activity has ..
  35. The Role of Calcium Signaling in Stem Cell Quiescence
    Gozde Yucel; Fiscal Year: 2010
    ..Studying stem cell quiescence is critical because disruption of quiescence leads to cancer. I intend to study the role of calcium signaling in hair follicle stem cell quiescence. ..
  36. HIV/Cocaine mediated human pulmonary vascular remodeling: Role of BMPR signaling.
    Navneet Kaur Dhillon; Fiscal Year: 2013
    ....
  37. Anti-inflammatory actions of bone morphogenetic protein signaling in the stomach
    Andrea Todisco; Fiscal Year: 2013
    ..The bone morphogenetic proteins, (BMP) s are regulatory peptides that exert important actions on the growth and differentiation of ..
  38. Bone Morphogenetic Protein Controls Links Between Dentinogenesis and Angiogenesis
    Audrey Rakian; Fiscal Year: 2013
    ..Through these studies, I will acquire state-of-the-art knowledge and skills toward my goal in becoming an established dental scientist. ..
  39. Genetic Pathways Directing Ventral Folding Morphogenesis in Mammalian Embryos
    ELIZABETH H LACY; Fiscal Year: 2013
    ....
  40. Mechanisms of Age-Related Skeletal Resistance to BMP-7 and IGF-I
    John C Lee; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone Morphogenetic proteins (BMPs) show great promise as bone anabolic agents in several therapeutic settings...
  41. Role of Twisted Gastrulation in Osteoclastogenesis
    Rajaram Gopalakrishnan; Fiscal Year: 2013
    ..The overall objective of this project is to identify the cellular targets of Twsg1-disruption and characterize the signaling and molecular mechanisms by which Twsg1 inhibits osteoclastogenesis. ..
  42. Signaling Crosstalk Controlled by a Mad Phosphoserine Code
    EDWARD V EIVERS; Fiscal Year: 2013
    ..We anticipate this proposal will contribute to the fields of development and cell signaling. In principle, by better understanding signaling processes, new strategies can be developed to protect and improve human health. ..
  43. BMP inhibitors and the study of disease mechanisms in anemia of inflammation
    Randall T Peterson; Fiscal Year: 2012
    ..Recent evidence has suggested a pivotal role for bone morphogenetic proteins (BMPs) in regulating hepcidin expression, raising the possibility that BMP antagonists could be used ..
  44. The role of Spry2 in regulation of bone formation
    Ophir D Klein; Fiscal Year: 2012
    ..Knowledge about the molecular pathways controlling bone formation and mineralization is thus of major clinical importance. The experiments in this R03 application will enhance our understanding of these pathways. ..
  45. The Cellular Basis of Heterotopic Ossification
    David J Goldhamer; Fiscal Year: 2013
    ....
  46. Elucidation of the FGF21-Bmp8b Axis in the Regulation of Energy Balance
    Katie Colbert Coate; Fiscal Year: 2013
    ..Collectively, these studies will provide insight into the novel relationship between FGF21 and Bmp8b in BAT, and shed light on FGF21's pharmacologic basis of action as it pertains to modulation of energy balance in vivo.! ..
  47. Role of the PDGF signaling pathway in pulmonary artery hypertension
    Akiko Hata; Fiscal Year: 2013
    ..In SA2, we will test the efficacy of perturbation of miR-24 in animal models of PAH. Finally, SA3 will demonstrate the deregulation of miR-24 in human PAH patients and identify novel targets of miR-24. ..
  48. Pre-emptive conditioning of the ischemic heart
    Dorothy E Vatner; Fiscal Year: 2012
    ..We will combine an in vitro system (isolated cardiac myocytes and gene knockdown) with mouse models in vivo (TG and KO) and a pre-clinical model (gene delivery in the swine) to address these goals comprehensively. ..
  49. Regulation of axonal outgrowth in the developing spinal cord
    Samantha J Butler; Fiscal Year: 2012
    ..We will examine these questions by determining how Bone Morphogenetic Proteins (BMPs) guide commissural (C) axons in the developing spinal cord...
  50. Mesenchymal Regulation of Osteogenesis
    Richard A Schneider; Fiscal Year: 2013
    ..The goal of this project is to identify genes and embryonic events that control bone formation. ..
  51. Bmp-signaling in craniofacial development
    JAMES FRANCIS MARTIN; Fiscal Year: 2012
    ..This research program will perform in depth investigation of Bmp-signaling during vertebrate development and will therefore provide insight into Bmp function with the long-term goal of uncovering therapeutic avenues for human patients. ..
  52. Combined Use of BMP-2 and Low Intensity Pulsed Ultrasound in Bone Regeneration
    AMARJIT SINGH VIRDI; Fiscal Year: 2010
    ..This research will focus on enhancing bone regeneration by applying a combination of two already approved FDA treatments and could be rapidly translated into clinical use. ..
  53. Urogenital System Development: The Acquisition of Coordinated Ureter Peristalsis
    Doris A Herzlinger; Fiscal Year: 2013
    ..Ultimately, our studies will reveal drug targets for the modification of ureter peristalsis and may reveal unappreciated causes of hydronephrosis. ..
  54. MOLECULAR CONTROL OF PATTERNING IN EARLY EAR DEVELOPMENT
    KATE BARALD; Fiscal Year: 2009
    ..Gene profiling through microarrays and analyses of loss- and gain-of-function experiments in these model systems will allow tests of all these hypotheses. ..
  55. TGF-beta polymorphisms and breast cancer in families
    Boris Pasche; Fiscal Year: 2013
    ..of the TGF-ss superfamily of growth factors comprises several TGF-ss isoforms, Activin isoforms, and Bone Morphogenetic Proteins, which are encoded by different genes but function through a similar receptor signaling system...
  56. Transcriptional control of collective cell migration
    Lionel Christiaen; Fiscal Year: 2013
    ..On the basis of preliminary observations, the hypotheses that (1) a ventral source of bone morphogenetic proteins (BMP) contributes to the L-T polarized expression of downstream target genes, including the Lef/Tcf ..
  57. Regulation of Limbal Epithelial Stem Cells by the Native Niche
    Scheffer C G Tseng; Fiscal Year: 2013
    ..Such an approach may one day help realize the considerable promise held by adult SCs in treating a number of diseases in the body. ..
  58. Clathrin-coated vesicles and endocytic function
    Linton M Traub; Fiscal Year: 2013
    ..The new information generated is likely to provide novel mechanistic insights and important conceptual advances in the appreciation of clathrin-mediated endocytosis. ..
  59. The regulatory role of Bone morphogenetic protein 1 in suture patency and fusion
    Matthew Harris; Fiscal Year: 2013
    ..Compounds that alter deleterious phenotypes in zebrafish with Bmp1a mutations may have therapeutic value in patients with synostosis or with BMP1-associated phenotypes. ..
  60. Mechanisms of BMP Receptor Kinase Dysregulation in Skeletal Dysplasias
    JAY CLEMENS GROPPE; Fiscal Year: 2011
    ....
  61. Molecular control of normal and neoplastic skin stem cells
    Andrey Sharov; Fiscal Year: 2013
    ..The goal of our study is to understand how family of molecules called Bone Morphogenetic Proteins regulates a process of stem cell renewal...
  62. Roles of Smad1 Dephosphorylation in Osteoblast Differentiation
    Xin Hua Feng; Fiscal Year: 2012
    Abrogation of cellular responses to Bone Morphogenetic Proteins (BMPs) and other members of TGF-( superfamily are associated with human bone diseases such as osteoporosis, pulmonary hypertension and heritable cancer...
  63. Bone Tissue Engineerig: Effect of Dynamic Perfusion
    Aaron Goldstein; Fiscal Year: 2009
    ..se/investors/annual_reports. 2005. 2. http://www.fda.gov/cdrh/MDA/DOCS/h020008.html. OP-1 Putty - H020008. 2004. 3. http://www.fda.gov/cdrh/mda/docs/p000058.html. InFUSE" Bone Graft/LT-CAGE" Lumbar Tapered Fusion Device - P000058. 2002. ..
  64. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  65. Novel Osteoinductive Protein Synthesizing Implant System
    Kyumin Whang; Fiscal Year: 2003
    ....
  66. Trafficking of BMP signals in neurons
    Guillermo Marques; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  67. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..from preosteoblasts to osteoblasts involves the secretion of a complex extracellular matrix containing bone morphogenetic proteins, growth factors and structural components that interact with cells to induce osteoblast-specific gene ..
  68. CLONING OF FAMILIAL PRIMARY PULMONARY HYPERTENSION GENE
    William Nichols; Fiscal Year: 2006
    ..abstract_text> ..
  69. Novel Formulations for Injectable Growth Factors
    Bruce Lamb; Fiscal Year: 2010
    ..Growth factors, particularly bone morphogenetic proteins (BMPs) are employed for a range of indications including spinal fusion and fracture healing due to ..
  70. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2005
    ..This study will contribute to the understanding of the mechanisms of cartilage repair/anabolism. ..
  71. Role of the BMP co-receptor Dragon (RGMb) in ovarian follicle development
    Herbert Y Lin; Fiscal Year: 2010
    ..We hope to identify new protein targets for development of methods to better manage fertility and ovarian-based disorders. ..
  72. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag
    HANNE GRON; Fiscal Year: 2010
    ..The use of Affinergy's proprietary peptides therefore provides effective leverage toward the near doubling of the orthobiologics market. ..
  73. The Role of BMP-7 in Chronic Kidney Disease
    Keith Hruska; Fiscal Year: 2005
    ..Successful completion of the proposed studies will significantly clarify the usefulness of BMP-7 in CKD, and encourage its development as a new therapeutic agent. ..
  74. BMP Receptor Signaling and Bone Remodeling
    Di Chen; Fiscal Year: 2005
    ..The mechanisms of bone formation during bone remodeling remain undefined. Bone morphogenetic proteins (BMPs) are multi-functional growth factors, which regulate a variety of biological functions...
  75. Improving BMP retention and healing in engineered bone
    ELSA BROCHMANN MURRAY; Fiscal Year: 2007
    ..Improving the retention time of BMP in SBGSs could reduce medical care costs, reduce healing time, and improve clinical outcomes. [unreadable] [unreadable] [unreadable]..