angiopoietins

Summary

Summary: A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.

Top Publications

  1. ncbi Angiopoietins in angiogenesis
    Ernesta Fagiani
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Lett 328:18-26. 2013
  2. pmc TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    David Padua
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 133:66-77. 2008
  3. ncbi Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis
    Toshiyuki Nakayama
    Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Oncol Rep 25:929-35. 2011
  4. ncbi Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors
    Pengcheng Zhu
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Cancer Cell 19:401-15. 2011
  5. ncbi Targeting the ANGPT-TIE2 pathway in malignancy
    Hanhua Huang
    CovX, Pfizer Inc, San Diego, CA 92121, USA
    Nat Rev Cancer 10:575-85. 2010
  6. ncbi Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage
    Young Jun Koh
    Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Cancer Cell 18:171-84. 2010
  7. ncbi Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance
    Mitsuhisa Tabata
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Cell Metab 10:178-88. 2009
  8. ncbi Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes
    Tsutomu Yamada
    Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 347:1138-44. 2006
  9. pmc Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    Aimin Xu
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 102:6086-91. 2005
  10. ncbi Emerging roles of angiopoietin-like 4 in human cancer
    Ming Jie Tan
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551
    Mol Cancer Res 10:677-88. 2012

Detail Information

Publications248 found, 100 shown here

  1. ncbi Angiopoietins in angiogenesis
    Ernesta Fagiani
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Lett 328:18-26. 2013
    ..The most exhaustively studied angiopoietins are Ang-1 and Ang-2...
  2. pmc TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    David Padua
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 133:66-77. 2008
    ....
  3. ncbi Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis
    Toshiyuki Nakayama
    Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Oncol Rep 25:929-35. 2011
    ..These findings suggest that ANGPTL4 is one of the factors involved in the progression of human colorectal cancer, especially venous invasion and distant metastasis...
  4. ncbi Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors
    Pengcheng Zhu
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Cancer Cell 19:401-15. 2011
    ..ANGPTL4 deficiency results in diminished O(2)(-) production and a reduced O(2)(-):H(2)O(2) ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target...
  5. ncbi Targeting the ANGPT-TIE2 pathway in malignancy
    Hanhua Huang
    CovX, Pfizer Inc, San Diego, CA 92121, USA
    Nat Rev Cancer 10:575-85. 2010
    b>Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis...
  6. ncbi Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage
    Young Jun Koh
    Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Cancer Cell 18:171-84. 2010
    Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available...
  7. ncbi Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance
    Mitsuhisa Tabata
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Cell Metab 10:178-88. 2009
    ..Thus, Angptl2 is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance...
  8. ncbi Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes
    Tsutomu Yamada
    Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 347:1138-44. 2006
    ..These results suggest that insulin downregulates angptl4 mRNA expression via PI3K/Foxo1 pathway in 3T3-L1 adipocytes, and that the reduction of angptl4 mRNA by insulin is attenuated in insulin resistance...
  9. pmc Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    Aimin Xu
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 102:6086-91. 2005
    ..These results collectively indicate that ANGPTL4 exerts distinct effects on glucose and lipid metabolism, and that its beneficial effect on glucose homeostasis might be useful for the treatment of diabetes...
  10. ncbi Emerging roles of angiopoietin-like 4 in human cancer
    Ming Jie Tan
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551
    Mol Cancer Res 10:677-88. 2012
    ..A better understanding of the underlying cellular and molecular mechanisms of ANGPTL4 will reveal novel insights into other aspects of tumorigenesis and the potential therapeutic value of ANGPTL4...
  11. pmc Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma
    Sebastien Le Jan
    INSERM U36, College de France, Paris
    Am J Pathol 162:1521-8. 2003
    ..This study also suggests that ANGPTL4 may provide a link between metabolic disorders and hypoxia-induced angiogenesis...
  12. ncbi How do angiopoietins Tie in with vascular endothelial growth factors?
    Pipsa Saharinen
    Molecular and Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Finland
    Curr Opin Hematol 17:198-205. 2010
    ....
  13. pmc Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
    Aurelie Cazes
    INSERM U36, College de France, Paris
    Circ Res 99:1207-15. 2006
    ..Altogether, these findings show that hypoxic endothelial cells accumulate ANGPTL4 in the ECM, which in turn negatively regulates their angiogenic capacities through an autocrine pathway...
  14. ncbi ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters
    Royston Luke Huang
    School of Biological Sciences, Nanyang Technological University, Singapore
    Blood 118:3990-4002. 2011
    ..Thus, our findings elucidate how cANGPTL4 induces endothelial disruption. Our findings have direct implications for targeting cANGPTL4 to treat cancer and other vascular pathologies...
  15. ncbi Clinicopathological significance of angiopoietin-like protein 4 expression in oesophageal squamous cell carcinoma
    Kenichiro Shibata
    Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Clin Pathol 63:1054-8. 2010
    ..Clinically, venous invasion resulting in distant metastasis is crucial for oesophageal cancer progression...
  16. ncbi The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Biol Chem 281:934-44. 2006
    ..Our data indicate that disturbances in FIAF signaling might be involved in dyslipidemia...
  17. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
    ..Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies...
  18. ncbi Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
    J Biol Chem 275:28488-93. 2000
    ..Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions...
  19. ncbi Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis
    Gavin Thurston
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Cell Tissue Res 314:61-8. 2003
    ..Some of the basic unanswered questions concerning Tie/Angiopoietin biology and the secondary stages of blood vessel formation are also highlighted...
  20. pmc Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness
    Ariane Galaup
    Institut National de la Sante et de la Recherche Medicale, Unit 36, 11 place Marcelin Berthelot, 75005 Paris, France
    Proc Natl Acad Sci U S A 103:18721-6. 2006
    ..Together, these results show that ANGPTL4, through its action on both vascular and tumor compartments, prevents the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness...
  21. pmc Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages
    Laeticia Lichtenstein
    Nutrigenomics Consortium, TI Food and Nutrition, 6700AN, Wageningen, The Netherlands
    Cell Metab 12:580-92. 2010
    ....
  22. ncbi Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells
    Zhiyong Zhang
    Department of Immunology, School of Medicine, Shandong University, Jinan 250012, China
    Cancer Lett 267:106-15. 2008
    ..These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis...
  23. pmc Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis
    Tatsuya Okada
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Pathol 176:2309-19. 2010
    ..Notably, Angptl2 promoted increased chemotactic activities of CD14+CD16- monocytes from synovial fluid of RA patients. Therefore, Angptl2 acts as an important rheumatoid synovium-derived inflammatory mediator in RA pathogenesis...
  24. ncbi Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion
    Toshiyuki Nakayama
    Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Oncol Rep 24:599-606. 2010
    ..ANGPTL4 expression was correlated with several clinicopathological factors, especially venous invasion. These findings suggest that the ANGPTL4 is one of the factors involved in the progression of human gastric cancer...
  25. pmc Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 58:579-89. 2009
    ..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)...
  26. ncbi Angiopoietin-related growth factor (AGF) promotes angiogenesis
    Yuichi Oike
    Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan
    Blood 103:3760-5. 2004
    ..On the basis of these observations, we propose that AGF is a novel angiogenic factor and that handling of its biologic functions could lead to novel therapeutic strategies for control of angiogenesis...
  27. ncbi Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis
    Jun Aoi
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Res 71:7502-12. 2011
    ..Overall, we propose that Angptl2 contributes to increased carcinogenesis and metastasis and represents a novel target to antagonize these pathologies...
  28. pmc A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia
    Anantha Harijith
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Am J Respir Cell Mol Biol 44:621-30. 2011
    ..IFNγ and its downstream targets may contribute significantly to the final common pathway of hyperoxia-induced injury in the developing lung and in human BPD...
  29. ncbi Angiopoietin-related growth factor antagonizes obesity and insulin resistance
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 11:400-8. 2005
    ..01) body weight loss and increases insulin sensitivity in mice fed a high-fat diet. This study establishes AGF as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance...
  30. ncbi Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm
    Hirokazu Tazume
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Chuo Ku, Kumamoto 860 8556, Japan
    Arterioscler Thromb Vasc Biol 32:1400-9. 2012
    ..In the present study, we asked whether Angptl2 and its associated chronic inflammation contribute to abdominal aortic aneurysm (AAA)...
  31. ncbi A mathematical model of tumour angiogenesis, regulated by vascular endothelial growth factor and the angiopoietins
    M J Plank
    School of Mathematics, University of Leeds, Leeds LS2 9JT, UK
    J Theor Biol 229:435-54. 2004
    ..In recent years, the angiopoietins have emerged as important regulators of angiogenesis...
  32. pmc Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes
    Michael G Borland
    Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Cell Signal 23:2039-50. 2011
    ....
  33. ncbi Angiopoietins and angiopoietin-like proteins in angiogenesis
    Tohru Morisada
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Endothelium 13:71-9. 2006
    ..Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and ..
  34. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
    b>Angiopoietins and their receptor Tie-2 are, in concert with VEGF-A, key mediators in angiogenesis...
  35. ncbi Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Circ Res 106:1712-21. 2010
    ..Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart...
  36. pmc Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight
    Hyun Kyong Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
    Diabetes 59:2772-80. 2010
    ..In the present study, we investigated the physiological role of Angptl4 in central regulation of body weight homeostasis...
  37. ncbi The acute phase response stimulates the expression of angiopoietin like protein 4
    Biao Lu
    Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 391:1737-41. 2010
    ..These studies demonstrate that ANGPTL4 is a positive acute phase protein and the increase in ANGPTL4 could contribute to the hypertriglyceridemia that characteristically occurs during the acute phase response by inhibiting LPL activity...
  38. pmc Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
    I Kim
    National Creative Research Initiatives Center for Cardiac Regeneration, Institute of Cardiovascular Research, Chonbuk National University School of Medicine, Chonju, 560 180, Korea
    Biochem J 346:603-10. 2000
    ..of HFARP contain the characteristic coiled-coil domains and fibrinogen-like domains that are conserved in angiopoietins. In human and mouse tissues, HFARP mRNA is specifically expressed in the liver...
  39. ncbi Angiopoietins: a link between angiogenesis and inflammation
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg 79106, Germany
    Trends Immunol 27:552-8. 2006
    ..This suggests that Ang-2 is the dynamic regulator of the Ang-Tie2 axis, thereby functioning as a built-in switch controlling the transition of the resting quiescent endothelium towards the activated responsive endothelium...
  40. ncbi The role of angiopoietin-like proteins in angiogenesis and metabolism
    Tai Hato
    Laboratory of Vascular Biology and Metabolism, Center for Integrated Medical Research, Department of General Thoracic Surgery, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Trends Cardiovasc Med 18:6-14. 2008
    Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls)...
  41. pmc Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis
    Melissa K Brunckhorst
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 70:7283-93. 2010
    ..b>Angiopoietins (Ang-1, Ang-2, and Ang-4) are the ligands of the Tie-2 receptor tyrosine kinase (RTK)...
  42. pmc Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma
    Tao Ma
    Department of Oncology and Diagnostic Sciences, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 107:14363-8. 2010
    ..As angiogenesis and increased vessel permeability are common themes in all solid tumors, these findings may have a broad impact on our understanding and treatment of cancer...
  43. pmc Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism
    Suneil K Koliwad
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:25593-601. 2009
    ..Overall, we establish that ANGPTL4 is a direct GR target that participates in glucocorticoid-regulated triglyceride metabolism...
  44. ncbi Angiopoietins in malignancy
    F Bach
    Department of Academic Surgery, Room B40, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds, West Yorkshire LS1 3EX, UK
    Eur J Surg Oncol 33:7-15. 2007
    ..Recent data suggest that this switch may occur when the balance of pro- and anti-angiogenic agents alters to promote angiogenesis. Angiopoietins may be involved in this balance.
  45. pmc Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis
    Lifeng Tian
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 69:9236-44. 2009
    ..Collectively, these studies suggest that activated PPARgamma induces Angptl4 to promote tumor growth through enhanced angiogenesis in vivo...
  46. ncbi Biological characterization of angiopoietin-3 and angiopoietin-4
    Hyuek Jong Lee
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    FASEB J 18:1200-8. 2004
    ..Ang3 and Ang4 both produced potent corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Thus, Ang3 and Ang4 are agonists of Tie2, but mouse Ang3 has strong activity only on endothelial cells of its own species...
  47. ncbi Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha
    Adam J Belanger
    Genzyme Corporation, 31 New York Avenue, Framingham, MA, 01701, USA
    J Mol Cell Cardiol 34:765-74. 2002
    ..These results suggest that hypoxic activation of PGAR expression is likely mediated by HIF-1 but not the PPARalpha/RXR pathway...
  48. ncbi Regulation of lipid metabolism via angiopoietin-like proteins
    S Kersten
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Biochem Soc Trans 33:1059-62. 2005
    ..This review summarizes contemporary data on ANGPTLs with emphasis on the connection with energy metabolism...
  49. pmc Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample
    Marius R Robciuc
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Public Health Genomics Research Unit, Biomedicum, Helsinki, Finland
    J Lipid Res 51:824-31. 2010
    ..016). The developed ELISAs will be important tools to clarify the role of ANGPTL 3 and 4 in human energy metabolism and partitioning of triglycerides between sites of storage (adipose tissue) and oxidation (skeletal and cardiac muscle)...
  50. pmc Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity
    Xia Lei
    Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 286:15747-56. 2011
    ..Blockage of ANGPTL4 cleavage reduces its inhibitory effects on LPL activity and decreases its ability to raise plasma triglyceride levels. In summary, the cleavage of ANGPTL4 by these PCs modulates its inhibitory effect on LPL activity...
  51. pmc Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes
    Nora E Gray
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720 3104, USA
    J Biol Chem 287:8444-56. 2012
    ..We show that Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes. Such a role is relevant to diseases of aberrant lipolysis, such as insulin resistance...
  52. ncbi Identification of a mammalian angiopoietin-related protein expressed specifically in liver
    D Conklin
    ZymoGenetics, Inc, 1201 Eastlake Avenue East, Seattle, Washington 98012, USA
    Genomics 62:477-82. 1999
    ..Human ANGPTL3 is a 460-amino-acid polypeptide with the characteristic structure of angiopoietins: a signal peptide, an extended helical domain predicted to form dimeric or trimeric coiled-coils, a short ..
  53. ncbi Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines
    Xue Feng Huang
    Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, PR China
    Oncol Rep 27:1541-7. 2012
    ..These results indicate that overexpression of Angptl4 may promote invasion and metastasis in CRC...
  54. ncbi Angiopoietin-like 4: a decade of research
    Pengcheng Zhu
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Biosci Rep 32:211-9. 2012
    ..The research findings over the past decade have laid the foundation for a better mechanistic understanding of the new scientific discoveries on the diverse roles of ANGPTL4...
  55. ncbi Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
    Dalhia Abramovich
    Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, C1428ADN, Buenos Aires, Argentina
    Endocrinology 153:3446-56. 2012
    ..In this study, we examined the ovarian expression of angiopoietins (ANGPT) and their receptor tyrosine kinase receptor (TIE2), involved in the stabilization of blood vessels, in ..
  56. ncbi Expression of angiopoietin-like 3 associated with puromycin-induced podocyte damage
    Rao Jia
    Department of Nephrology, Children s Hospital of Fudan University, Shanghai, People s Republic of China
    Nephron Exp Nephrol 115:e38-45. 2010
    ..In conclusion, ANGPTL3 expression is upregulated in puromycin-induced podocyte damage and is associated with the reduction of perlecan and agrin expression...
  57. pmc Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing
    Yan Yih Goh
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    J Biol Chem 285:32999-3009. 2010
    ..It also underscores the importance of cell-matrix communication during angiogenesis and cancer metastasis...
  58. ncbi Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia
    Christoph Schliemann
    Department of Medicine Hematology and Oncology, and the IZKF Muenster, University of Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Haematologica 91:1203-11. 2006
    ..Angiopoietin-1 (Ang-1) and its natural antagonist angiopoietin-2 (Ang-2), both ligands for the receptor tyrosine kinase Tie2, are known to play an essential role in normal and pathological angiogenesis...
  59. ncbi ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo
    Gieri Camenisch
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:17281-90. 2002
    ..Taken together, our data demonstrate that ANGPTL3 is the first member of the angiopoietin-like family of secreted factors binding to integrin alpha(v)beta(3) and suggest a possible role in the regulation of angiogenesis...
  60. ncbi The role of the Angiopoietins in vascular morphogenesis
    Markus Thomas
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Angiogenesis 12:125-37. 2009
    ..The better mechanistic understanding of the Ang/Tie system is gradually paving the way toward the rationale exploitation of this vascular signaling system as a therapeutic target for neoplastic and non-neoplastic diseases...
  61. pmc Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Genet 39:513-6. 2007
    ..Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history...
  62. pmc Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma
    Jérôme Verine
    INSERM, U833, Paris, France
    PLoS ONE 5:e10421. 2010
    ..We here investigated whether angptl4 mRNA 1) could be a useful diagnostic and/or prognostic marker of ccRCC in a large and comprehensive retrospective series, 2) induction is dependent on the VHL status of tumors...
  63. ncbi Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro
    Xia Gao
    Department of Nephrology, Children s Hospital of Fudan University, Shanghai, China
    Biochem Biophys Res Commun 399:31-6. 2010
    ..In conclusion, we found ANGPTL3 to be capable of regulating the motility and permeability of podocytes and that the mechanism of ANGPTL3's regulation could be associated with the altered expression of nephrin...
  64. ncbi Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases
    Tsuyoshi Kadomatsu
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Japan
    FEBS J 278:559-64. 2011
    ..Recently, a family of proteins structurally similar to the angiogenic-regulating factors known as angiopoietins was identified and designated 'angiopoietin-like proteins' (ANGPTLs)...
  65. ncbi Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines
    Charlotte Grootaert
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, B 9000 Ghent, Belgium
    Environ Microbiol 13:1778-89. 2011
    ....
  66. pmc GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
    William K Sonnenburg
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Lipid Res 50:2421-9. 2009
    ..Moreover, therapeutic agents that prevent LPL inhibition by ANGPTL4 or, to a lesser extent, ANGPTL3, may benefit individuals with hyperlipidemia caused by gene mutations associated with decreased LPL stability...
  67. ncbi Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed
    Elena Makoveichuk
    Department of Medical Biosciences, Physiological Chemistry Umeå University, SE 901 87 Umea, Sweden
    Biochem Biophys Res Commun 425:138-43. 2012
    ..Antibodies against ANGPTL4 interfered with the inactivation of LPL. We conclude that inactivation of LPL in THP-1 macrophages primarily occurs on the cell surface where oligomers of ANGPTL4 are formed...
  68. ncbi Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3
    Russell Brown
    Department of Obstetrics, Faculty of Medicine, Dalhousie University, Halifax, N S, Canada
    Neuroendocrinology 85:232-41. 2007
    ..However, it remains to be determined whether these in vitro results can be translated to the control of adipokine expression in brain and adipose tissue...
  69. pmc Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins
    Marius R Robciuc
    National Institute for Health and Welfare, Biomedicum, Helsinki, Finland
    J Lipid Res 52:1575-82. 2011
    ..24, P = 0.01) and at-ABHD5 (r = 0.41, P = 0.005) expression. Our results demonstrated that variation in Angptl4 concentration was only modestly accounted for by genetic factors and suggest a role for Angptl4 in acquired obesity in humans...
  70. pmc Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome
    Lionel C Clement
    Glomerular Disease Therapeutics Laboratory, and Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 17:117-22. 2011
    ..These results suggest that podocyte-secreted Angptl4 has a key role in nephrotic syndrome...
  71. ncbi Autocrine pathway of angiopoietins-Tie2 system in AML cells: association with phosphatidyl-inositol 3 kinase
    Motohiro Wakabayashi
    Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan
    Hematol J 5:353-60. 2004
    ..Various angiogenic factors, such as vascular endothelial growth factor (VEGF) and angiopoietins (Angs), are thought to be associated with leukemia cell growth...
  72. pmc Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors
    Toshiyuki Nakayama
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    World J Gastroenterol 11:964-9. 2005
    ..Angiopoietin (Ang)-1 is known as a ligand of Tie-2 tyrosine kinase receptor. The objective of this study was to establish a comprehensive Tie-1 and Tie-2 and Ang-1, 2 and 4 expression profile in human colorectal adenocarcinomas...
  73. ncbi Angptl3 regulates lipid metabolism in mice
    Ryuta Koishi
    Biomedical Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    Nat Genet 30:151-7. 2002
    ..This increase was also observed in C57BL/6J normal mice. Taken together, these data suggest that Angptl3 regulates lipid metabolism in animals...
  74. pmc Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription
    Kerstin Kaddatz
    Institute of Molecular Biology and Tumor Research, Philipps University, Emil Mannkopff Strasse 2, 35032 Marburg, Germany
    J Biol Chem 285:29469-79. 2010
    ..Although the PPAR-E is not regulated by TGFβ, it interacts with SMAD3, ETS1, RUNX2, and AP-1 in vivo, providing a possible mechanistic explanation for the observed synergism...
  75. pmc Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration
    Yan Yih Goh
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    Am J Pathol 177:2791-803. 2010
    ..Our findings provide insight into a novel cell migration control mechanism and underscore the physiological importance of the modulation of integrin activity in cancer metastasis...
  76. pmc Angiopoietins 3 and 4: diverging gene counterparts in mice and humans
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 96:1904-9. 1999
    The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium...
  77. pmc An evolutionary framework for association testing in resequencing studies
    C Ryan King
    Department of Health Studies, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 6:e1001202. 2010
    ..We demonstrate our approach on a population-based re-sequencing study of association between serum triglycerides and variation in ANGPTL4...
  78. pmc Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways
    Cliona M Stapleton
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Exp Cell Res 316:507-16. 2010
    ..This induction may play a role in tissue remodeling during lung injury and be implicated in several lung pathologies...
  79. ncbi Different degrees of vascularization and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues
    Margreet Plaisier
    Department of Biomedical Research, TNO Quality of Life, Leiden, The Netherlands
    Fertil Steril 88:176-87. 2007
    ..Comparison of these tissues provides information about the regulation of vascularization by pregnancy-induced hormones and/or the extravillous trophoblast (EVT)...
  80. pmc A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions
    Dajiang J Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 6:e1001156. 2010
    ..A number of novel associations were identified, including the associations of high density lipoprotein and very low density lipoprotein with ANGPTL4. The KBAC method is implemented in a user-friendly R package...
  81. pmc Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Invest 119:70-9. 2009
    ..Thus, ANGPTL3, ANGPTL4, and ANGPTL5, but not ANGPTL6, play nonredundant roles in TG metabolism, and multiple alleles at these loci cumulatively contribute to variability in plasma TG levels in humans...
  82. ncbi Angiopoietins: vascular growth factors looking for roles in glomeruli
    Adrian S Woolf
    Nephro Urology Unit, UCL Institute of Child Health, London, UK
    Curr Opin Nephrol Hypertens 19:20-5. 2010
    ..The present review highlights general advances concerning angiopoietin (Ang) biology and then focuses on possible roles of these molecules within healthy and diseased glomeruli...
  83. ncbi Roles of angiopoietins in kidney development and disease
    Adrian S Woolf
    Nephro Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Am Soc Nephrol 20:239-44. 2009
    b>Angiopoietins are a family of growth factors, the best studied being angiopoietin 1 (Ang-1), which binds to and tyrosine-phosphorylates endothelial Tie-2, causing enhanced survival and cell-cell stabilization...
  84. pmc The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk
    Melissa C Smart-Halajko
    Centre for Cardiovascular Genetics, University College London, 5 University St, London WC1E 6JF, England
    Arterioscler Thromb Vasc Biol 30:2277-82. 2010
    ..To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants...
  85. ncbi Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke
    Tania M Hansen
    University of Leicester, Department of Cardiovascular Sciences, RKCSB, Leicester, UK
    Curr Neurovasc Res 5:236-45. 2008
    ....
  86. ncbi Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins
    Yueqing Zhang
    Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, PR China
    Biochem Biophys Res Commun 347:100-8. 2006
    ..Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism...
  87. ncbi Food restriction regulates adipose-specific cytokines in pituitary gland but not in hypothalamus
    Glen Wiesner
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, 5980 University Avenue, Halifax, NS, Canada B3J 3G9
    J Endocrinol 180:R1-6. 2004
    ..Overall, our data suggest that pituitary-derived adipokines may play an unexpected role in the neuroendocrine regulation of energy homeostasis...
  88. pmc Angiopoietin-like 4: a novel molecular hallmark in oral Kaposi's sarcoma
    Jiadi Hu
    Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Oral Oncol 47:371-5. 2011
    ..These surprising results support a key role for ANGPTL4 in Kaposi's sarcomagenesis and further suggest that this angiogenic factor may provide a novel diagnostic and therapeutic marker for oral KS patients...
  89. ncbi [Expression of Kindlins and angiopoietins in acute myeloid leukemia]
    Wen Bin Wu
    Chinese Academy of Medical Sciences, Tianjin, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:7-11. 2012
    ..It is concluded that Ang-1 closely correlated with the poor prognosis of AML. Kindlin-2 lowly expresses in AML, which has a close relation with the favorable prognosis of AML. Kindlin-2 can be a marker for favorable prognosis of AML...
  90. pmc Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
    Cheng Cheng Zhang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Med 12:240-5. 2006
    ..The coiled-coil domain of Angptl2 was capable of stimulating expansion of HSCs. Furthermore, angiopoietin-like 5, angiopoietin-like 7 and microfibril-associated glycoprotein 4 also supported expansion of HSCs in culture...
  91. ncbi Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice
    N Mizutani
    Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Exp Clin Endocrinol Diabetes 120:139-44. 2012
    ..In the present study, we elucidated Angptl4 expression in the mouse models of type 1 and type 2 diabetes mellitus, and investigated the possible mechanisms involved...
  92. ncbi Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis
    Motoyoshi Endo
    Department of Molecular Genetics, Kumamoto University, Kumamoto, Japan
    Cancer Res 72:1784-94. 2012
    ..Overall, our findings showed that tumor cell-derived ANGPTL2 drives metastasis and provided an initial proof of concept for blockade of its action as a strategy to antagonize the metastatic process...
  93. ncbi Fatty acids and hypoxia stimulate the expression and secretion of the adipokine ANGPTL4 (angiopoietin-like protein 4/ fasting-induced adipose factor) by human adipocytes
    Pedro González-Muniesa
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, UK
    J Nutrigenet Nutrigenomics 4:146-53. 2011
    ..We have examined the effects of hypoxia and fatty acids, alone and together, on the expression and release of ANGPTL4 by human adipocytes...
  94. pmc Angiopoietins, abdominal aortic aneurysm and atherosclerosis
    Alexandra F Trollope
    The Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Douglas Campus, Townsville, Qld 4811, Australia
    Atherosclerosis 214:237-43. 2011
    ..Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis...
  95. pmc Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation
    J C Yoon
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:5343-9. 2000
    ..Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis...
  96. ncbi Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    Hellmut G Augustin
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, and German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Germany
    Nat Rev Mol Cell Biol 10:165-77. 2009
    ..The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system...
  97. pmc Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure
    Minna W B Olsen
    Laboratory of Experimental Oncology, Institute of Molecular Pathology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Neoplasia 8:364-72. 2006
    b>Angiopoietins (Ang) are involved in the remodeling, maturation, and stabilization of the vascular network...
  98. ncbi Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma
    Toshiyuki Nakayama
    Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, Japan
    World J Gastroenterol 13:4473-9. 2007
    ..To investigate the role of angiopoietin (Ang) -1, -2 and -4 and its receptors, Tie-1 and -2, in the growth and differentiation of gastrointestinal stromal tumors (GISTs)...
  99. ncbi Expression of VEGF and angiopoietins in subfoveal membranes from patients with age-related macular degeneration
    Ruxandra Hera
    Department of Opthalmology, University Hospital of Grenoble, La Tronche, France
    Am J Ophthalmol 139:589-96. 2005
    Vascular endothelial growth factor (VEGF) and angiopoietins are key regulators of angiogenesis...
  100. pmc Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production
    Olga Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Am J Physiol Endocrinol Metab 295:E1056-64. 2008
    ..Thus, the interplay between VEGF and ANGPTL4 could lead to a net expansion of the adipose tissue capillary network, required for adipose tissue growth, in response to PPARgamma activators...
  101. ncbi Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4
    Yasuhiro Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Cancer Res 63:6651-7. 2003
    b>Angiopoietins and angiopoietin-related proteins (ARPs) have been shown to regulate angiogenesis, a process essential for various neovascular diseases including tumors...

Research Grants47

  1. Angiopoietins in vascular and lymphatic remodeling of airways and lung
    Donald M McDonald; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project will test the overall hypothesis that angiopoietins influence the severity and duration of inflammatory responses in the airways and lung, by regulating the remodeling of blood vessels ..
  2. Regulation of vascular maturation/regression in diabetes
    Jian xiong Chen; Fiscal Year: 2013
    ..This revised proposal will investigate a possible disruption in the angiopoietins (Ang)/Tie-2 and apelin pathway in abnormal diabetes- associated vascular maturation and capillary regression...
  3. Stromal Stem Cells of Human Placenta for the Treatment of Acute Lung Injury
    Fernando Viteri; Fiscal Year: 2013
    ..signaling and secrete abundant quantities of growth factors like HGF, KGF, TGF-beta, FGF, GM-CSF, and angiopoietins. Stromal cells from the placenta are effective in restoration of barrier function of injured epithelial layers...
  4. CORONARY BLOOD VESSELS AND HEART DISEASE
    Thomas Sato; Fiscal Year: 2004
    ..of these projects we will be able to provide comprehensive in vivo evaluations of the degree of usefulness of angiopoietins and their downstream signaling pathway components in therapeutic angiogenesis...
  5. Biochemical and Biophysical Analysis of Angiopoietin Signaling
    William A Barton; Fiscal Year: 2012
    ..role of alpha5beta1 integrin in angiopoietin signaling by biochemically characterizing the interactions of the angiopoietins and Tie2 with the alpha5beta1 integrin receptor, and iv) identify chemical tools, including small peptides, ..
  6. A Novel Model to Study Retinopathy of Prematurity
    David Moscatelli; Fiscal Year: 2003
    ..model by examining expression of the different VEGF-A isoforms, other members of the VEGF family, and the angiopoietins. We will determine if the expression pattern that occurs in retinal vascular development and in the response ..
  7. Angiopoietins in Prostate Biology and Disease
    David Moscatelli; Fiscal Year: 2005
    ..prostate is regulated by the balance between signals from vascular endothelial growth factor (VEGF) and the angiopoietins. We will investigate the hypotheses that 1) normal prostate growth is dependent on angiogenesis that is ..
  8. Acquired Resistance to VEGF blockade in Wilms tumor
    Jessica Kandel; Fiscal Year: 2007
    ..on changes in endothelium, recruited perivascular cells, and expression of angiogenesis-related genes (VEGF, angiopoietins, platelet-derived growth factor-B (PDGF-B), and Eph/Ephrins)...
  9. The Angiopoietins in Vascular Maintenance and Remodeling
    Christopher Kontos; Fiscal Year: 2005
    ..Based on this information, we hypothesize that the Angiopoietins will have differential effects on vascular remodeling; specifically that Ang1, but not Ang2, will prevent ..
  10. Tie2 Regulation and Role in Pathological Angiogenesis
    CLARENCE FINDLEY; Fiscal Year: 2007
    ..Tie2 and the Angiopoietins [unreadable] are essential components of embryonic and post-natal angiogenesis...
  11. Regulation of Microvascular Development in BPD
    William Maniscalco; Fiscal Year: 2006
    ..control of several families of angiogenic factors, including Vascular Endothelial Growth Factor (VEGF) and the Angiopoietins. These factors interact and their correct temporal and spatial expression pattern is essential for normal ..
  12. Angiopoietins in Angiogenesis
    Qin Yu; Fiscal Year: 2006
    ..The long-term objective of this proposal is to elucidate the roles of angiopoietins in angiogenesis and determine how these roles are regulated...
  13. Effects of the Angiopoietins on Tie 2 Downregulation
    Christopher Kontos; Fiscal Year: 2005
    ..Tie2 is unique among RTKs in that its ligands, the Angiopoietins, have apparently opposite actions...
  14. The Role of Vascular Maturation in Adipose Tissue Growth
    SUSAN DALLABRIDA; Fiscal Year: 2006
    ..will be tested through the following specific aims: 1) Characterize the expression and functional role of angiopoietins and tie receptors, regulators of vessel maturation, in adipose tissue during growth or regression using mouse ..
  15. The role of angiopoietins in Wilms tumor
    Jianzhong Huang; Fiscal Year: 2009
    ..training in a mentored environment to study the role of key mediators of vessel formation and remodeling, angiopoietins-1 and -2 (Ang-1, Ang-2), in the development of vasculature in Wilms tumor...
  16. The Role of Tie2 and the Angiopoietins in EPC Biology
    GREGORY LAM; Fiscal Year: 2006
    ..3. Investigate whether inhibition of Tie2 signaling or overexpression of the angiopoietins alters EPC homing to and the prevention of atherosclerotic lesions...
  17. Regulation of Angiopoietin mRNA Stability
    John Vogel; Fiscal Year: 2007
    ..of eye disease (including the role of PI3K in ocular disease) and angiogenesis (including the regulation angiopoietins), respectively...
  18. The Role of ADAM15 in sTie2 shedding in Ischemic Angiogenesis
    Daniel Corey; Fiscal Year: 2009
    ..The ligands for Tie2, the Angiopoietins, have context-dependent effects on angiogenesis and vascular maintenance...
  19. Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
    Dimitar Nikolov; Fiscal Year: 2007
    ..Our preliminary structural, biophysical and biochemical characterization of the angiopoietins, Tie2, and of their interactions, suggests that small-molecules would be able to disrupt the Tie2/Ang complex ..
  20. EXERCISE TRAINING AND PERIPHERAL ARTERIAL INSUFFICIENCY
    RONALD TERJUNG; Fiscal Year: 2004
    ..which endothelial signaling of NO, alters regulation of VEGF and its receptors (VEGFR-1 and VEGFR-2), and the angiopoietins (Ang1 and Ang2, and their receptor Tie2) is modified to stimulate arteriogenesis in collateral vessels in vivo,..
  21. AAV Mediated Angiogenic Therapy for Coronary Disease
    YUET KAN; Fiscal Year: 2006
    ..3) We will compare the effectiveness of AAV delivery of the genes for VEGF and angiopoietins, alone and in different combinations...
  22. DELIVERY AND REGULATION OF ANGIOGENIC GENES
    Helen Blau; Fiscal Year: 2003
    ..g. the angiopoietins) in order to better understand blood vessel modeling and remodeling...
  23. ANGIOGENIC BYPASS & GENE THERAPY RESPONSE MECHANISMS
    Todd Rosengart; Fiscal Year: 2003
    ..relevant neovascularization, 2) neovascularization can be enhanced by angiogenesis "co-factors", such as the angiopoietins, which are thought to play a role in vascular sprouting and stabilization, and 3) transgene expression can be ..
  24. Structure Study of Angiopoietins and the Tie2 Receptor
    Dimitar Nikolov; Fiscal Year: 2008
    ..The Angiopoietin/Tie receptor-ligand system plays a central role in these events. The Angiopoietins are secreted molecules that signal through the endothelial specific Tie2 receptor...
  25. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
  26. ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEART
    Robert Tomanek; Fiscal Year: 2003
    ..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
  27. Lipoprotein Metabolism 2008 Gordon Research Conference
    Robert Hegele; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  28. Function of VEGF Receptor-1 on Colorectal Cancer Cells
    Lee Ellis; Fiscal Year: 2009
    ..In addition, it is possible that VEGFR-1 expression on CRC cells may serve as a "predictive factor" for anti-VEGF/receptor containing anti-neoplastic regimens. ..
  29. Nutrition, Fetal Growth, and Placental Angiogenesis
    Lawrence P Reynolds; Fiscal Year: 2010
    ..abstract_text> ..
  30. Conceptus-Dependent Effects on the Endometrium
    Brent Bany; Fiscal Year: 2009
    ....
  31. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 2003
    ....
  32. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Such an approach will provide a rational basis for the development of potentially powerful and effective therapeutics for ocular neovascularization. ..
  33. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  34. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..mice, indicate that vascular endothelial growth factors (VEGF), fibroblast growth factors (FGF), and angiopoietins (ANG) play major roles in the development and organization of the placental vasculature...
  35. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  36. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  37. Molecular changes in slit diaphragm related proteinuria
    Sumant Chugh; Fiscal Year: 2005
    ..This study will bring us one step closer to understanding the pathogenesis of proteinuria, and will also help to correlate our existing knowledge of the in vitro characteristics of slit diaphragm proteins with in vivo function. ..
  38. Prenatal Hypoxia and Development of Insulin Resistance
    RUSSELL ANTHONY; Fiscal Year: 2006
    ..These studies will provide insight in to the role fetal hypoxia alone may play in the development of Syndrome X. [unreadable] [unreadable]..
  39. BIOLOGY OF OVARIAN CANCER
    Robert Jaffe; Fiscal Year: 2005
    ..The projects will be subserved by three cores: Administration, Biometry and Tissue/Pathology. ..
  40. Nephritogenic Glomerular Epithelial Cell Antigen
    Sumant Chugh; Fiscal Year: 2005
    ..This project allows me to learn new skills at three different labs that have access to state-of-the-art technology, and will facilitate my transition towards becoming an independent investigator. ..
  41. Functional role of Angiopoietin-2 in diabetic heart
    Jian xiong Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Vascular Protection in Acute Ischemic Stroke
    Susan Fagan; Fiscal Year: 2005
    ..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
  43. MATURATION OF CEREBROVASCULAR CONTRACTILE MECHANISMS
    William Pearce; Fiscal Year: 2005
    ..abstract_text> ..
  44. THE GENE FOR SCHNYDER'S CRYSTALLINE CORNEAL DYSTROPHY
    JAYNE WEISS; Fiscal Year: 2002
    ..abstract_text> ..
  45. Transcriptional regulation of proteinuria
    Sumant Chugh; Fiscal Year: 2007
    ..This will lead to the devlopment of appropriate treatment strategies in the future. ..
  46. MATURATION OF CEREBROVASCULAR RELAXANT MECHANISMS
    William Pearce; Fiscal Year: 2009
    ..This approach should also identify which cGMP-dependent mechanisms may be most amenable to therapeutic pharmacological manipulation in the critically ill neonate. ..