intercellular signaling peptides and proteins

Summary

Summary: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

Top Publications

  1. ncbi Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
    K Tatemoto
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
    Biochem Biophys Res Commun 251:471-6. 1998
  2. ncbi The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
  3. ncbi Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
  4. ncbi Secreted antagonists of the Wnt signalling pathway
    Yoshiaki Kawano
    Department of Cancer Cell Biology, Division of Medicine, Imperial College, London W12 0NN, UK
    J Cell Sci 116:2627-34. 2003
  5. ncbi Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
    Matt Baker
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 442:916-9. 2006
  6. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
  7. ncbi PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue
    Toshiya Matsubara
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Cell Metab 15:38-50. 2012
  8. pmc The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
    Wei Tang
    Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Science 332:478-84. 2011
  9. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    N Engl J Med 346:1513-21. 2002
  10. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006

Research Grants

  1. Somatomedin: Autologous Regulator of Bone Formation
    Ernesto Canalis; Fiscal Year: 2008
  2. Metalloproteinase regulation of ErbB signaling in skin
    Stefan Stoll; Fiscal Year: 2006
  3. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
  4. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
  5. MOLECULAR RECLASSIFICATION OF PROSTATIC CANCER
    George Michalopoulos; Fiscal Year: 2004
  6. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
  7. Surfactant Protein C Mutations:Interstitial Lung Disease
    Michael Beers; Fiscal Year: 2006
  8. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
  9. Inhibition of VEGF Mediated Angiogenesis by TIMP-3
    Bela Anand Apte; Fiscal Year: 2009
  10. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010

Detail Information

Publications331 found, 100 shown here

  1. ncbi Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
    K Tatemoto
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
    Biochem Biophys Res Commun 251:471-6. 1998
    ....
  2. ncbi The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
    ..The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions...
  3. ncbi Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
    ..Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification...
  4. ncbi Secreted antagonists of the Wnt signalling pathway
    Yoshiaki Kawano
    Department of Cancer Cell Biology, Division of Medicine, Imperial College, London W12 0NN, UK
    J Cell Sci 116:2627-34. 2003
    ..In addition, there are other protein interactions that contribute to Wnt antagonist function. Moreover, certain sFRPs and Dkks do not antagonise Wnt function, which suggests that these families have as-yet-undiscovered functions...
  5. ncbi Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
    Matt Baker
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 442:916-9. 2006
    ..Our results identify mutations in PGRN as a cause of neurodegenerative disease and indicate the importance of PGRN function for neuronal survival...
  6. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  7. ncbi PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue
    Toshiya Matsubara
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Cell Metab 15:38-50. 2012
    ..Thus, PGRN is a key adipokine that mediates HFD-induced insulin resistance and obesity through production of IL-6 in adipose tissue, and may be a promising therapeutic target for obesity...
  8. pmc The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
    Wei Tang
    Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Science 332:478-84. 2011
    ..They also suggest new potential therapeutic interventions for various TNFα-mediated pathologies and conditions, including rheumatoid arthritis...
  9. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    N Engl J Med 346:1513-21. 2002
    ..Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis-pseudoglioma...
  10. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  11. ncbi A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
    Thorsten Buch
    Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Nat Methods 2:419-26. 2005
    ..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo...
  12. ncbi DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway
    Atsushi Niida
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Oncogene 23:8520-6. 2004
    ..Our finding suggests the existence of a novel feedback loop in Wnt signaling...
  13. ncbi Granulin is a soluble cofactor for toll-like receptor 9 signaling
    Boyoun Park
    Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, South Korea
    Immunity 34:505-13. 2011
    ..Thus, we propose that granulin contributes to innate immunity as a critical soluble cofactor for TLR9 signaling...
  14. pmc The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1
    Zhicheng Dong
    Biology Department and Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 105:9970-5. 2008
    ..We show that recombinant HYL1 and SE proteins accelerate the rate of DCL1-mediated cleavage of pre- and pri-miR167b substrates and promote accurate processing...
  15. ncbi Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    Bingyu Mao
    Molecular Embryology Division, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 417:664-7. 2002
    ..The results indicate that Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates...
  16. ncbi Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
    Kerry B Goralski
    Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 282:28175-88. 2007
    ..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
  17. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  18. pmc MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation
    Sara T Hashimi
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Blood 114:404-14. 2009
    ..Thus, our novel approach identified and validated some miRNA-protein networks involved in phenotypic and functional MDDC differentiation...
  19. ncbi Essential role of beta-catenin in postnatal bone acquisition
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:21162-8. 2005
    ..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts...
  20. ncbi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ....
  21. ncbi LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    B Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 411:321-5. 2001
    ..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
  22. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
  23. ncbi Apelin, a newly identified adipokine up-regulated by insulin and obesity
    Jeremie Boucher
    Institut National de la Santé et de la Recherche Médicale Unité 586, Institut Fédératif de Recherche 31, Centre Hospitalier Universitaire Rangueil, BP 84225 F 31432 Toulouse Cedex 4, France
    Endocrinology 146:1764-71. 2005
    ..The present work identifies apelin as a novel adipocyte endocrine secretion and focuses on its potential link with obesity-associated variations of insulin sensitivity status...
  24. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
    ..Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors...
  25. ncbi SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    Mikhail Semenov
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26770-5. 2005
    ..Our findings suggest that SOST is an antagonist for Wnt signaling and that the loss of SOST function likely leads to the hyperactivation of Wnt signaling that underlies bone overgrowth seen in sclerosteosis patients...
  26. ncbi Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    Xiaofeng Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, 06030, USA
    J Biol Chem 280:19883-7. 2005
    ....
  27. pmc Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana
    Sascha Laubinger
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 105:8795-800. 2008
    ..Taken together, our results uncover dual roles in splicing and miRNA processing that distinguish SE and the cap-binding complex from specialized miRNA processing factors such as DCL1 and HYL1...
  28. ncbi Structure, function, and mechanism of progranulin; the brain and beyond
    Huishi Toh
    Endocrine Research Laboratory, Royal Victoria Hospital, McGill University Health Centre Research Institute, 687 Pine Ave West, Montreal, QC, H3A 1A1, Canada
    J Mol Neurosci 45:538-48. 2011
    ..Here we review the structure, biology, and mechanism of progranulin action. By understanding PGRN in a wider context, we may be better able to delineate its roles in the normal brain and in neurodegenerative disease...
  29. pmc Effect of NKG2D ligand expression on host immune responses
    Marine Champsaur
    Department of Microbiology and Immunology, The Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Immunol Rev 235:267-85. 2010
    ..We also discuss the host response to both membrane-bound and secreted NKG2D ligands and summarize the models proposed to explain the consequences of this differential expression...
  30. ncbi The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer
    Jose Manuel Gonzalez-Sancho
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, E 28029 Madrid, Spain
    Oncogene 24:1098-103. 2005
    ..Our data indicate that the Wnt/beta-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer...
  31. ncbi Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    M V Semenov
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 11:951-61. 2001
    ..The significance of the Fz-LRP6 complex in signal transduction remains to be established...
  32. ncbi GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity
    Takeshi Yoshimura
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Cell 120:137-49. 2005
    ..Knockdown of CRMP-2 inhibited NT-3-induced axon outgrowth. These results suggest that NT-3 decreases phosphorylated CRMP-2 and increases nonphosphorylated active CRMP-2, thereby promoting axon outgrowth...
  33. pmc Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
    Moshe Elkabets
    Department of Medicine, Hematology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:784-99. 2011
    ..Our data suggest that GRN and the unique hematopoietic BMCs that produce it might serve as novel therapeutic targets...
  34. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  35. pmc Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
    Vivianna M Van Deerlin
    1 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 2 These authors contributed equally to this work
    Nat Genet 42:234-9. 2010
    ..TMEM106B variants also contribute to genetic risk for FTLD-TDP in individuals with mutations in GRN. Our data implicate variants in TMEM106B as a strong risk factor for FTLD-TDP, suggesting an underlying pathogenic mechanism...
  36. pmc Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants
    Yuda Fang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 17:818-23. 2007
    ..On the basis of these data, we propose that D-bodies are crucial for orchestrating pri-miRNA processing and/or storage/assembly of miRNA-processing complexes in the nuclei of plant cells...
  37. ncbi Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme
    Markus Hutterer
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Clin Cancer Res 14:130-8. 2008
    ..However, the effect of Axl and its ligand growth arrest--specific gene 6 (Gas6) in human gliomas is still unknown...
  38. ncbi Chemerin is a novel adipokine associated with obesity and metabolic syndrome
    Kiymet Bozaoglu
    Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
    Endocrinology 148:4687-94. 2007
    ..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
  39. pmc Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    Daniel Pinto
    Netherlands Institute for Developmental Biology, Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Genes Dev 17:1709-13. 2003
    ..Thus, our data are the first to establish a direct requirement for Wnt ligands in driving proliferation in the intestinal epithelium, and also define an unexpected role for Wnts in controlling secretory cell differentiation...
  40. pmc Synthetic chemerin-derived peptides suppress inflammation through ChemR23
    Jenna L Cash
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 205:767-75. 2008
    ..Collectively, these results show that chemerin-derived peptides may represent a novel therapeutic strategy for the treatment of inflammatory diseases through ChemR23...
  41. pmc Hippo pathway-independent restriction of TAZ and YAP by angiomotin
    Siew Wee Chan
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    J Biol Chem 286:7018-26. 2011
    ..These results reveal a novel mechanism to restrict the activity of TAZ and YAP through physical interaction with Amot and AmotL1...
  42. pmc Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration
    Basar Cenik
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 287:32298-306. 2012
    ..Revealing the cell surface receptors and the intracellular functions of granulins and progranulin is crucial for understanding their contributions to neurodegeneration...
  43. pmc Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
    F Xing
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
    Oncogene 30:4075-86. 2011
    ....
  44. ncbi Function and biological roles of the Dickkopf family of Wnt modulators
    C Niehrs
    Department of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany
    Oncogene 25:7469-81. 2006
    ..In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease...
  45. pmc Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis
    Wei Jie Zhou
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 21:609-26. 2011
    ..We conclude that engagement of Robo1 by Slit2 induces malignant transformation through Hakai-mediated E-cad ubiquitination and lysosomal degradation during colorectal epithelial cell carcinogenesis...
  46. pmc Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells
    Lei Liu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
    J Biol Chem 285:19483-90. 2010
    ..These findings also provide a step forward toward understanding the operating mechanisms during reprogramming to produce iPS cells and can potentially promote the application of iPS cells in regenerative medicine and cancer therapy...
  47. ncbi Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair
    Jing Zhu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 111:867-78. 2002
    ..Supplying PEPI corrects the wound-healing defect in SLPI null mice. Thus, SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing...
  48. pmc LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling
    Hui Wen Lue
    Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
    PLoS ONE 6:e27720. 2011
    ..LIV-1 could be an attractive therapeutic target for the eradication of pre-existing human prostate cancer and bone and soft tissue metastases...
  49. ncbi Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
    Hiroyasu Kidoya
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Blood 115:3166-74. 2010
    ..Apelin inhibited the down-modulation of vascular endothelial-cadherin by VEGF, resulting in suppression of hyperpermeability. Our results suggest apelin efficacy for therapeutic angiogenesis...
  50. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
  51. pmc LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs
    Rik Schrijvers
    Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium
    PLoS Pathog 8:e1002558. 2012
    ..These results further support the potential of LEDGINs as allosteric integrase inhibitors...
  52. pmc Differential effects of EGFR ligands on endocytic sorting of the receptor
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, The Panum Building, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Traffic 10:1115-27. 2009
    ..The Cbl ubiquitin ligases, especially c-Cbl, are responsible for EGFR ubiquitination after stimulation with all ligands, and persistent EGFR phosphorylation and ubiquitination largely correlate with receptor degradation...
  53. ncbi Nodal promotes growth and invasion in human gliomas
    C C Lee
    Department of Pathology, Shin Kong Memorial Hospital, Taipei, Taiwan
    Oncogene 29:3110-23. 2010
    ..Furthermore, our data support the notion that Nodal may regulate glioma progression through the induction of the leukemia inhibitory factor (LIF) and Cripto-1 through activated Smad...
  54. ncbi Wnt signalling in stem cells and cancer
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 434:843-50. 2005
    ....
  55. pmc Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice
    Fangfang Yin
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    J Exp Med 207:117-28. 2010
    ..FTD associated with PGRN insufficiency may result from many years of reduced neutrotrophic support together with cumulative damage in association with dysregulated inflammation...
  56. ncbi Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha
    Klaus F Wagner
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Respir Cell Mol Biol 31:276-82. 2004
    ..These results indicate a role for HIMF in lung development, possibly under the control of HIF-2, and suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation...
  57. pmc A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 22:2651-63. 2008
    ..These studies provide the first comprehensive characterization of the transcriptional output of a Shh-patterning process in the mammalian embryo and a framework for elaborating regulatory networks in the developing limb...
  58. pmc Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
    Veronica Rodilla
    Institut d Investigació Biomèdica de Bellvitge Gran Via km 2 7, Hospitalet and Institut Municipal d Investigacions Mèdiques Hospital del Mar, Dr Aiguader 88, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 106:6315-20. 2009
    ..The Notch-specific genetic signature is sufficient to block differentiation and promote vasculogenesis in tumors whereas proliferation depends on both pathways...
  59. ncbi Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
    O Aguilera
    Instituto de Investigaciones Biomédicas Alberto Sols and Departamento de Bioquímica, Facultad de Medicina, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 25:4116-21. 2006
    ....
  60. ncbi Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
    A Reaux
    Institut National de la Sante et de la Recherche Medicale, Paris, France Laboratory of Neuromorphology, Faculty of Medicine Semmelweis University, Budapest, Hungary
    J Neurochem 77:1085-96. 2001
    ..Together, these results suggest that neuronal apelin plays an important role in the central control of body fluid homeostasis...
  61. ncbi Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 50:1126-33. 2001
    ..No clear association was found between the plasma levels of adiponectin and its mRNA levels in adipose tissue. These results suggest that reduction in circulating adiponectin may be related to the development of insulin resistance...
  62. pmc Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    Heather E Fleming
    Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 2:274-83. 2008
    ..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells...
  63. ncbi A new secreted protein that binds to Wnt proteins and inhibits their activities
    J C Hsieh
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 398:431-6. 1999
    ....
  64. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
    ..Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders...
  65. ncbi The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    T N Stitt
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
    Cell 80:661-70. 1995
    ....
  66. ncbi A novel serum protein similar to C1q, produced exclusively in adipocytes
    P E Scherer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:26746-9. 1995
    ..Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes...
  67. pmc Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    J Fruebis
    Genset Corporation, Functional Genomics, 875 Prospect Street, No. 206, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:2005-10. 2001
    ..Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level...
  68. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
  69. ncbi Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
    L Li
    Stowers Institute for Medical Research, Department of Molecular Biotechnology, University of Washington, Seattle 98195 USA
    Nat Genet 16:243-51. 1997
    ....
  70. pmc Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
    Tero Pekka Alastalo
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
    J Clin Invest 121:3735-46. 2011
    ..Taken together, our findings suggest that apelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction...
  71. ncbi Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo
    Christopher M Cox
    Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724 5044, USA
    Dev Biol 296:177-89. 2006
    ..Taken together, these studies indicate that apelin is required for normal vascular development in the frog embryo and has properties consistent with a role during normal and pathological angiogenesis...
  72. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  73. ncbi Insulin-sensitive obesity
    Nora Kloting
    Department of Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Germany
    Am J Physiol Endocrinol Metab 299:E506-15. 2010
    ..This suggests that mechanisms beyond a positive caloric balance such as inflammation and adipokine release determine the pathological metabolic consequences in patients with obesity...
  74. ncbi Identification and functional analysis of endothelial tip cell-enriched genes
    Raquel del Toro
    Inserm U833, Paris, France
    Blood 116:4025-33. 2010
    ..Thus, tip cells may regulate angiogenesis via matrix remodeling, production of basement membrane, and release of secreted molecules, some of which regulate stalk cell behavior...
  75. ncbi Wnt signaling in the intestinal epithelium: from endoderm to cancer
    Alex Gregorieff
    Netherlands Institute for Developmental Biology, Hubrecht Laboratory, 3584 CT Utrecht, The Netherlands
    Genes Dev 19:877-90. 2005
    ..In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer...
  76. ncbi Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Obes Surg 19:1574-80. 2009
    ..We measured the changes in apelin levels in morbidly obese subjects, with and without diabetes, and in the inverse situation of improvement in carbohydrate metabolism as a result of bariatric surgery...
  77. pmc Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9
    Yuhui Wang
    Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Metab 9:287-302. 2009
    ..Thus, Sox9 is a Pref-1 target, and Pref-1 directs multipotent mesenchymal cells to the chondrogenic lineage but inhibits differentiation into adipocytes as well as osteoblasts and chondrocytes...
  78. ncbi The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2
    Tien Shun Yeh
    Department of Anatomy and Cell Biology, National Yang Ming University, Taipei 112, Taiwan
    Cancer Res 69:5039-48. 2009
    ..Taken together, these results suggest that activation of Notch1 signal pathway promotes progression of gastric cancer, at least in part through COX-2...
  79. pmc Macrophage Wnt7b is critical for kidney repair and regeneration
    Shuei Liong Lin
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:4194-9. 2010
    ....
  80. pmc The many facets of Notch ligands
    B D'Souza
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1737, USA
    Oncogene 27:5148-67. 2008
    ..Oncogene (2008) 27, 5148-5167; doi:10.1038/onc.2008.229...
  81. pmc Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
    Kevin G Leong
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    J Exp Med 204:2935-48. 2007
    ..Our findings suggest that ligand-induced Notch activation, through the induction of Slug, promotes tumor growth and metastasis characterized by epithelial-to-mesenchymal transition and inhibition of anoikis...
  82. ncbi Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma
    Xianzhou Song
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:734-43. 2011
    ..Although previous studies have identified the role of Axl in the transformation, proliferation, survival, and invasion in cancers, the expression and functions of Axl in pancreatic cancer have not been studied in detail...
  83. ncbi Genomic imprinting at the mammalian Dlk1-Dio3 domain
    Simao Teixeira da Rocha
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Trends Genet 24:306-16. 2008
    ..Here, we discuss the function and regulation of imprinting at this domain...
  84. pmc Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration
    Andrea L Ferris
    HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 107:3135-40. 2010
    ..The ability to redirect HIV-1 DNA integration may help solve the problems associated with the activation of oncogenes when retroviruses are used in gene therapy...
  85. ncbi Neomorphic agouti mutations in obese yellow mice
    D M Duhl
    Department of Pediatrics, Stanford School of Medicine, California 94305
    Nat Genet 8:59-65. 1994
    ..These results provide a model for other genes that show allele-specific imprinting, and demonstrate that molecular mechanisms typically responsible for activation of proto-oncogenes can also lead to other disease phenotypes...
  86. ncbi Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway
    Hiroshi Doi
    Department of Medicine and Biological Science, Education and Research Center, Laboratory Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
    J Biol Chem 281:28555-64. 2006
    ..Given that Notch pathway components are expressed in vascular SMC during normal development and disease, Notch signaling is likely to play a pivotal role in such situations to modulate the vascular smooth muscle cell phenotype...
  87. ncbi The granulin gene family: from cancer to dementia
    Andrew Bateman
    Endocrine Research Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada
    Bioessays 31:1245-54. 2009
    ..In this review we will discuss current knowledge of the multifaceted biology of PGRN...
  88. pmc LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin
    Rik Gijsbers
    Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Ther 18:552-60. 2010
    ..Thus, engineered LEDGF/p75 chimeras provide technology for controlling integration site selection by lentiviral vectors...
  89. ncbi In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75
    Melissa McNeely
    Laboratory for Molecular Virology and Gene Therapy, Molecular Medicine, KULeuven and IRC KULAK, Kapucijnenvoer 33, B 3000 Leuven, Flanders, Belgium
    J Mol Biol 410:811-30. 2011
    ....
  90. ncbi SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis
    Li Yang
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Plant J 47:841-50. 2006
    ..Our data strongly suggest that SE plays an important and general role in pri-miRNA processing, and it would be interesting to determine whether animal SE homologues may play similar roles in vivo...
  91. pmc AXL is an essential factor and therapeutic target for metastatic ovarian cancer
    Erinn B Rankin
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 70:7570-9. 2010
    ..Furthermore, this study defines the soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer, for which current therapies are ineffective...
  92. ncbi Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes
    Mahmood Mohtashami
    Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Immunol 185:867-76. 2010
    ....
  93. pmc Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin
    Fenghua Hu
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06536, USA
    Neuron 68:654-67. 2010
    ..5- to 5-fold. The 50% PGRN decrease causative in FTLD-TDP cases is mimicked in GRN+/⁻ mice, and is fully normalized by Sort1 ablation. Sortilin-mediated PGRN endocytosis is likely to play a central role in FTLD-TDP pathophysiology...
  94. pmc Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin
    Kai Kessenbrock
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    J Clin Invest 118:2438-47. 2008
    ..We conclude that PR3 and NE enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of PGRN. Our results support the use of serine protease inhibitors as antiinflammatory agents...
  95. ncbi TGF-beta signaling and the fibrotic response
    Andrew Leask
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
    FASEB J 18:816-27. 2004
    ....
  96. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  97. pmc A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells
    Aimee W Kao
    Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:4441-6. 2011
    ..We propose that cells that might otherwise recover from damage or injury are destroyed in progranulin mutants, which in turn facilitates disease progression...
  98. ncbi Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review
    Harro Seelaar
    Department of Neurology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:476-86. 2011
    ..The potential to establish an early diagnosis, predict underlying pathology during life and quantify disease progression will all be required for disease-specific therapeutic trials in the future...
  99. pmc Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis
    Sacri R Ferron
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Nature 475:381-5. 2011
    ....
  100. ncbi Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
    Q Lu
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 398:723-8. 1999
    ..Additional observations indicate that these receptors may also be essential for the tropic maintenance of diverse cell types in the mature nervous, immune and reproductive systems...
  101. pmc Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
    NiCole Finch
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain 132:583-91. 2009
    ..We propose that plasma GRN levels could be used as a reliable and inexpensive tool to identify all GRN mutation carriers in early-onset dementia populations and asymptomatic at-risk individuals...

Research Grants72

  1. Somatomedin: Autologous Regulator of Bone Formation
    Ernesto Canalis; Fiscal Year: 2008
    ..These investigations should clarify the role of CHOP in bone cell differentiation and function. [unreadable] [unreadable]..
  2. Metalloproteinase regulation of ErbB signaling in skin
    Stefan Stoll; Fiscal Year: 2006
    ..Specific Aim 2 determines whether and in which contexts ADAM10 is involved in the shedding of ErbB ligands in human KCs. ..
  3. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..abstract_text> ..
  4. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  5. MOLECULAR RECLASSIFICATION OF PROSTATIC CANCER
    George Michalopoulos; Fiscal Year: 2004
    ..abstract_text> ..
  6. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  7. Surfactant Protein C Mutations:Interstitial Lung Disease
    Michael Beers; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
    ..abstract_text> ..
  9. Inhibition of VEGF Mediated Angiogenesis by TIMP-3
    Bela Anand Apte; Fiscal Year: 2009
    ..2. To determine the potential role of heparin/heparan sulfate binding on the angiostatic activity of TIMP-3. 3. To determine the VEGF mediated angiogenic response and tumor growth in TIMP-3 null mice. ..
  10. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..The proposed studies will provide a sound scientific basis for developing an antioxidant-based therapy or combination of therapies for preventing cataractogenesis and age-associated degenerative diseases in general. ..
  11. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  12. TGF BETA Regulation of Osteoclast Apoptosis
    MERRY OURSLER; Fiscal Year: 2007
    ..Understanding osteoclast apoptosis regulation may provide important avenues for therapies to slow bone degradation during pathological bone loss. ..
  13. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  14. Control of lymphatic endothelial differentiation program
    Kari Alitalo; Fiscal Year: 2006
    ..They should also identify molecular markers distinguishing superficial and visceral lymphatic vessels, which could then be used to develop targeted drug delivery to these vessels. ..
  15. Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular Remodeling
    AMY DODD BRADSHAW; Fiscal Year: 2010
    ..Thus, this project will examine whether alteration in SPARC-dependent procollagen processing is a fundamental mechanism by which PO increases myocardial fibrillar collagen content and causes diastolic dysfunction. ..
  16. Novel CATERPILLER gene involved in mucosal inflammation
    Beckley Davis; Fiscal Year: 2006
    ..Biochemical analysis of 16.1/NOD27 has shown it to be a regulator of NF-K B dependent gene expression. These data suggest a role for 16.1/NOD27 in the inflammatory response associated with active colitis. ..
  17. Carbohydrate-carbohydrate interaction in basic cell biology
    Sen itiroh Hakomori; Fiscal Year: 2006
    ..abstract_text> ..
  18. Pancreatic Islets: From Development to Transplantation
    ALVIN POWERS; Fiscal Year: 2005
    ..This meeting will foster interactions of different scientific disciplines in an effort to address gaps in our knowledge about the pancreatic islet in health and disease. ..
  19. Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis Patients
    Hirohito Kita; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Regulation of Cellular Senescence by MEG3 RNA
    Yunli Zhou; Fiscal Year: 2007
    ..Therefore, another specific aim is to determine how MEGS activates p53. Whether MEG3 RNA activates p53 through repression of Mdm2 expression will be the focus of investigation. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. Hepatoma derived growth factor and vascular smooth muscle cell proliferation
    Allen D Everett; Fiscal Year: 2010
    ..We propose here to determine the mechanism regulating the activity of this protein to provide the basis for the future design of new drugs to treat cardiovascular disease. ..
  22. Models of P. carinii Infection: SP-A and SP-D null mice
    Michael Beers; Fiscal Year: 2009
    ....
  23. Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
    Ravi Salgia; Fiscal Year: 2011
    ..Conduct an anti-c-Met phase I/I I clinical trial against NSCLC. Through the achievement of the goals proposed in these specific aims, we will arrive at novel therapy against c- Met in lung cancer. ..
  24. Prostaglandin Signaling in Wear Debris-induced Osteolysis
    REGIS O KEEFE; Fiscal Year: 2009
    ....
  25. NEURAL REGULATION OF BONE REMODELING
    Wade Kingery; Fiscal Year: 2008
    ..These investigations will help to identify the sensory transmitters that modulate bone remodeling and characterize their roles in osteoporotic processes. ..
  26. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2008
    ..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  27. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  29. Antigen Presenting Cells in the Induction of GVHD
    Yi Zhang; Fiscal Year: 2008
    ..abstract_text> ..
  30. GLP-1 to Enhance Islet Transplantation
    ALVIN POWERS; Fiscal Year: 2007
    ..abstract_text> ..
  31. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  32. Aging-Cancer Research Program Development at CWRU CCC
    Nathan Berger; Fiscal Year: 2007
    ..abstract_text> ..
  33. BD Biosciences FACS Canto Flow Cytometer
    LAWRENCE LAMB; Fiscal Year: 2006
    ..The laboratory will require an instrument that will serve the laboratory in the development and execution of advanced cell therapy trials. [unreadable] [unreadable]..
  34. PHOSPHOLIPASE C GAMMA 1--BIOCHEMISTRY AND BIOLOGY
    Graham Carpenter; Fiscal Year: 2006
    ..The result of these proposed experiments should significantly increase current understanding of how PLCgamma1 participates in growth factor-dependent mitogenesis. ..
  35. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
  36. TRANSCRIPTIONAL CONTROL OF TH2 CELL DIFFERENTIATION
    Wei Ping Zheng; Fiscal Year: 2004
    ..It is proposed that knowledge gained from these studies will advance understanding and improve treatment of immunological diseases such as allergy and infection where Th2 responses are critical. ..
  37. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  38. PROSTACYCLIN SYNTHESIS IN PULMONARY HYPERTENSION
    Norbert Voelkel; Fiscal Year: 2001
    ..Lung endothelial cells and airway cells of rats also will be transfected with the PGI2 synthase gene and their response to hypoxia examined. ..
  39. Molecular Determinants of Vascularization in Islets
    ALVIN POWERS; Fiscal Year: 2003
    ..We anticipate that information about islet revascularization from these studies will be directly relevant to transplantation in humans and will be useful in planning future interventions in humans. ..
  40. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  41. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2003
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  42. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  43. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  44. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  45. GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2002
    ..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
  46. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
    ..The broad long term goal of this proposal is to gain an understanding of the mechanism(s) by which alterations in matrix integrity may regulate retinal neovascularization using TIMP-3 mutations in SFD as a model. ..
  47. MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRIN
    Filippo Giancotti; Fiscal Year: 2002
    ..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
  48. VIRAL AND IMMUNE RESPONSE TO THERAPY FOR HIV IN THE GALT
    Andrew Talal; Fiscal Year: 2003
    ..This project amy provide important insights into the amount of time needed to treat HIV- infected individuals and may provide novel approaches by which to monitor therapeutic responses in these individuals. ..
  49. Role of IL-8 in Cell Migration and Proliferation
    Ingrid Schraufstatter; Fiscal Year: 2004
    ....
  50. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  51. Primed Stroma: A Tumor Permissive Microenvironment
    Edna Cukierman; Fiscal Year: 2005
    ..Developing therapeutic approaches focusing on containing cancer as a chronic and innocuous disease is our ultimate goal. ..
  52. Characterization of Ocular Neural Stem Cells
    Iqbal Ahmad; Fiscal Year: 2004
    ..abstract_text> ..
  53. Role of IL-18 and TNF-a in Necrotizing Enterocolitis
    Bohuslav Dvorak; Fiscal Year: 2005
    ..Data obtained from these studies will be used to determine the feasibility of pursuing anti-IL-18 or anti-TNF-alpha treatment in clinical trials. ..
  54. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  55. SPARC Modulates Extracellular Matrix Dynamics in Skin
    AMY BRADSHAW; Fiscal Year: 2004
    ....
  56. DIFFERENTIATION OF GRANULOCYTES AND MACROPHAGES
    Donald Metcalf; Fiscal Year: 2004
    ..abstract_text> ..
  57. Mice Overexpressing rtTA and Cre in Corneal Epithelium
    WINSTON KAO; Fiscal Year: 2004
    ..These mouse lines will be useful in preparing mouse lines for studies of altered genetic functions from the corneal epithelium-specific gene ablation and overexpression of reporter genes. ..
  58. Stem cell manipulation via HOX gene regulation
    Stephen G Emerson; Fiscal Year: 2010
    ..These experiments will describe in detail the role of NF-Y in the biology of hematopoietic stem cells, and will develop two experimental therapies based directly on the biology of NF-Y, for both HSC expansion and HSC differentiation. ..
  59. 2008 Musculoskeletal Biology and Bioengineering Gordon Research Conference
    Farshid Guilak; Fiscal Year: 2008
    ..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  61. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  62. A Novel Substrate of Src Tyrosine Kinases
    John Seykora; Fiscal Year: 2006
    ..The rest of the applicant's effort, 15%, will involve diagnosing skin biopsies. ..
  63. Seasonal Plasticity of Brain and Behavior
    Leah Pyter; Fiscal Year: 2005
    ..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
  64. Training in Biomolecular and Tissue Engineering
    Farshid Guilak; Fiscal Year: 2007
    ..We will also take advantage of several long-standing and successful initiatives at Duke University to enhance the recruitment of underrepresented minorities as part of this post-doctoral training program. ..
  65. Mechanism of EGF-Mediated Reduction of NEC
    Bohuslav Dvorak; Fiscal Year: 2009
    ..These studies will elucidate the mechanisms of EGF-mediated reduction of NEC, information that is essential to initiate use of EGF as a preventative or treatment modality for human NEC. ..
  66. Regulation of Human TLR3 & TLR9 Expression and Function
    Steven Young; Fiscal Year: 2004
    ..Thus, the proposed studies will contribute to an understanding of mechanisms regulating human endometrial cytokine expression, which could lead to the design of pharmacologic therapies for both infectious and reproductive disorders. ..
  67. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
    ..The opportunities provided by the training program will provide the foundation for career advancement and hopefully lead to new therapies for fibrotic lung diseases. ..
  68. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Melanie Mediavilla Varela; Fiscal Year: 2008
    ..These studies will provide insights into the mechanisms underlying prostate tumor resistance to cell death and lead to development of novel therapeutic strategies for PCa. [unreadable] [unreadable] [unreadable]..
  69. Ameloblastin Function in the Periodontal Ligament
    Xianghong Luan; Fiscal Year: 2008
    ..These studies might eventually lead to novel cures for gum diseases. [unreadable] [unreadable] [unreadable]..
  70. Regulation of osteoclastogenesis by TRANCE
    Yongwon Choi; Fiscal Year: 2004
    ....
  71. LEUCINE-RICH REPEAT PROTEIN LRRc17 AND OSTEOCLASTS
    Yongwon Choi; Fiscal Year: 2009
    ....