growth inhibitors


Summary: Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).

Top Publications

  1. ncbi Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM)
    Jan M Schwab
    Institute of Brain Research, Eberhard Karls University Tuebingen, School of Medicine, Calwer Str 3, D 72076 Tuebingen, Germany
    Eur J Neurosci 21:1569-76. 2005
  2. ncbi Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
    P Caroni
    Brain Research Institute, University of Zurich, Switzerland
    Neuron 1:85-96. 1988
  3. ncbi Highwire restrains synaptic growth by attenuating a MAP kinase signal
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Neuron 51:57-69. 2006
  4. pmc Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors
    Daniel Fisher
    Department of Neurology and Neuroscience Graduate Program, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Neurosci 31:14051-66. 2011
  5. ncbi Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
    N Stahl
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591
    Science 263:92-5. 1994
  6. ncbi Morphological changes in early melanoma development: influence of nutrients, growth inhibitors and cell-adhesion mechanisms
    Clément Chatelain
    Laboratoire de Physique Statistique, Ecole Normale Superieure, UPMC Universite Paris 06, Universite Paris Diderot, CNRS, Paris, France
    J Theor Biol 290:46-59. 2011
  7. ncbi Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
    M S Chen
    Brain Research Institute, Department of Neuromorphology, University of Zurich, Switzerland
    Nature 403:434-9. 2000
  8. ncbi Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    S Akira
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 77:63-71. 1994
  9. ncbi Targeting neurite growth inhibitors to induce CNS regeneration
    Abba J Kastin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 11:1247-53. 2005
  10. ncbi Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration
    Axel Sandvig
    Laboratory of Regenerative Neurobiology, Institute for Experimental Medical Research, Ulleval University Hospital, Oslo, Norway
    Glia 46:225-51. 2004

Detail Information

Publications219 found, 100 shown here

  1. ncbi Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM)
    Jan M Schwab
    Institute of Brain Research, Eberhard Karls University Tuebingen, School of Medicine, Calwer Str 3, D 72076 Tuebingen, Germany
    Eur J Neurosci 21:1569-76. 2005
    ..To date, RGM is one of the most potent axonal growth inhibitors identified and present in axonal growth impediments (i) oligodendrocytes; (ii) the plexus choroideus and (..
  2. ncbi Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
    P Caroni
    Brain Research Institute, University of Zurich, Switzerland
    Neuron 1:85-96. 1988
    ..We conclude that the nonpermissive substrate properties of CNS white matter are due to these membrane proteins on the surface of differentiated oligodendrocytes and to their in vivo product, myelin...
  3. ncbi Highwire restrains synaptic growth by attenuating a MAP kinase signal
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Neuron 51:57-69. 2006
    ..In addition to controlling synaptic growth, Highwire promotes synaptic function through a separate pathway that does not require wallenda...
  4. pmc Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors
    Daniel Fisher
    Department of Neurology and Neuroscience Graduate Program, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Neurosci 31:14051-66. 2011
    ..Identification of LAR as a novel CSPG functional receptor provides a therapeutic basis for enhancing axonal regeneration and functional recovery after CNS injuries in adult mammals...
  5. ncbi Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
    N Stahl
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591
    Science 263:92-5. 1994
    ..Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines...
  6. ncbi Morphological changes in early melanoma development: influence of nutrients, growth inhibitors and cell-adhesion mechanisms
    Clément Chatelain
    Laboratoire de Physique Statistique, Ecole Normale Superieure, UPMC Universite Paris 06, Universite Paris Diderot, CNRS, Paris, France
    J Theor Biol 290:46-59. 2011
    ..Its results have important implications for the improvement of the diagnostic methods for melanoma, possibly driving progress towards a personalized screening...
  7. ncbi Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
    M S Chen
    Brain Research Institute, Department of Neuromorphology, University of Zurich, Switzerland
    Nature 403:434-9. 2000
    ..These data show that Nogo-A is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity...
  8. ncbi Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    S Akira
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 77:63-71. 1994
  9. ncbi Targeting neurite growth inhibitors to induce CNS regeneration
    Abba J Kastin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 11:1247-53. 2005
    ..The p75 neurotrophin receptor probably represents the signaling part of the receptor complex for neurite growth inhibitors. There is evidence in vitro that the inhibitory actions of MAG and myelin are blocked if neurons are primed ..
  10. ncbi Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration
    Axel Sandvig
    Laboratory of Regenerative Neurobiology, Institute for Experimental Medical Research, Ulleval University Hospital, Oslo, Norway
    Glia 46:225-51. 2004
    ..secreted molecules; Ephrins expressed on astrocyte/fibroblast membranes; the myelin/oligodendrocyte-derived growth inhibitors Nogo, MAG, and OMgp; and membrane-bound semaphorins (Sema) produced by meningeal fibroblasts invading the ..
  11. ncbi Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes
    Atsushi Fukunaga
    Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Immunol 172:4091-9. 2004
    ..These observations show that the ligation of SHPS-1 with the SHPS-1 mAb or with CD47-Fc abrogates the migration of LCs in vivo and in vitro, which suggests that the SHPS-1-CD47 interaction may negatively regulate LC migration...
  12. ncbi Flavaglines: a group of efficient growth inhibitors block cell cycle progression and induce apoptosis in colorectal cancer cells
    Barbara Hausott
    Institute of Cancer Research, University of Vienna, Vienna, Austria
    Int J Cancer 109:933-40. 2004
    ..Strong activation of p38 was observed after 2 hr of exposure, indicating that apoptosis may be induced via a p38-mediated stress pathway...
  13. ncbi Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression
    L Tessitore
    Dipartimento di Scienze Chimiche Alimentari Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale Amedeo Avogadro, Vercelli, Italy
    Carcinogenesis 21:1619-22. 2000
    ..In conclusion, the results suggest a protective role of RV in colon carcinogenesis with a mechanism involving changes in bax and p21 expression...
  14. ncbi Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
    M Thallmair
    Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 1:124-31. 1998
    ..Neutralization of myelin-associated neurite growth inhibitors thus restores in adults the structural plasticity and functional recovery normally found only at perinatal ..
  15. ncbi Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation
    J L Escary
    Unité d Embryologie Moléculaire de l Institut Pasteur, URA 1148 du CNRS, Paris, France
    Nature 363:361-4. 1993
    ..LIF thus appears to be required for the survival of the normal pool of stem cells, but not their terminal differentiation...
  16. ncbi Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
    C L Stewart
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Nature 359:76-9. 1992
    ..The blastocysts, however, are viable and, when transferred to wild-type pseudopregnant recipients, they can implant and develop to term...
  17. pmc Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    Yuichi Hori
    Department of Developmental Biology and Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:16105-10. 2002
    ..Strategies for producing cells that can replace islet functions described here can be adapted for similar uses with human cells...
  18. ncbi Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis
    Susan Keay
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Urology 61:1278-84. 2003
  19. ncbi Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors
    Nadia Chahboune
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Valencia, Burjassot, Spain
    Bioorg Med Chem 14:1089-94. 2006
    ..Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents...
  20. ncbi Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts
    Cell 79:315-28. 1994
    ..We here show that the inhibition of metastases by a primary mouse tumor is mediated, at least in part, by angiostatin...
  21. pmc Identification of indole derivatives as self-growth inhibitors of Symbiobacterium thermophilum, a unique bacterium whose growth depends on coculture with a Bacillus sp
    Tomo o Watsuji
    Life Science Research Center, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252 8510, Japan
    Appl Environ Microbiol 73:6159-65. 2007
    ..The results suggest that Bacillus benefits S. thermophilum by detoxifying BII and BIE in the coculture. A similar mechanism may underlie mutualistic relationships between different microorganisms...
  22. ncbi Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells
    T Yin
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202
    J Biol Chem 269:3731-8. 1994
    ..These results suggest that pp90rsk is one of the potential candidates for the H7-sensitive protein kinase(s), which is critical for the activation of primary response genes by these cytokines...
  23. ncbi Impact of sirolimus-eluting stents on outcome in diabetic patients: a SIRIUS (SIRolImUS-coated Bx Velocity balloon-expandable stent in the treatment of patients with de novo coronary artery lesions) substudy
    Issam Moussa
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, 130 East 77th St, 9th Floor, New York, NY 10021, USA
    Circulation 109:2273-8. 2004
    ..The purpose of this analysis was to determine the impact of sirolimus-eluting stents on outcomes of diabetic compared with nondiabetic patients...
  24. ncbi Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation
    Peter S Vezeridis
    Department of Oral Cell Biology, Academic Center of Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 348:1082-8. 2006
    ..Thus, the osteocyte appears to be more responsive to PFF than the osteoblast or periosteal fibroblast with respect to the production of soluble signaling molecules affecting osteoblast proliferation and differentiation...
  25. ncbi CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
    N Y Ip
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Cell 69:1121-32. 1992
    ..Thus, the receptor system for CNTF is surprisingly unlike those used by the nerve growth factor family of neurotrophic factors, but is instead related to those used by a subclass of hematopoietic cytokines...
  26. ncbi Inhibition of osteoclast differentiation by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration
    I Voronov
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, Toronto, ON, Canada
    Biochem Pharmacol 70:300-7. 2005
    ..These results suggest that the inhibitory effects of PAHs on osteoclastogenesis are direct and likely involve interaction of the RANKL and PAH signaling pathways...
  27. ncbi Quiescence, cell viability, apoptosis and necrosis of smooth muscle cells using different growth inhibitors
    J Pelisek
    Medical Clinic I, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
    Cell Prolif 34:305-20. 2001
    ..In conclusion, quiescent cells simulate more realistically the in vivo situation and may therefore represent a better model for future in vivo experiments based on in vitro findings...
  28. ncbi G-rich oligonucleotide inhibits the binding of a nuclear protein to the Ki-ras promoter and strongly reduces cell growth in human carcinoma pancreatic cells
    Susanna Cogoi
    Department of Biomedical Science and Technology, School of Medicine, University of Udine, Piazzale Kolbe, 4, 33100 Udine, Italy
    Biochemistry 43:2512-23. 2004
    ..Our data showed that transcript T-22AG acted as a molecular aptamer, binding specifically to a nuclear factor essential for Ki-ras expression. The biological implications of this study are discussed...
  29. ncbi New frontiers in cardiology: drug-eluting stents: Part II
    J Eduardo Sousa
    Institute Dante Pazzanese of Cardiology, Av Dr Dante Pazzanese, 500 Ibirapuera, 04012180, Sao Paulo, Brazil
    Circulation 107:2383-9. 2003
  30. ncbi Natural product growth inhibitors of Mycobacterium tuberculosis
    Brent R Copp
    Department of Chemistry, University of Auckland, Auckland, New Zealand
    Nat Prod Rep 24:278-97. 2007
  31. ncbi Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi
    Chiara B Vicentini
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, via Fossato di Mortara 17, Ferrara, Italy
    J Agric Food Chem 55:10331-8. 2007
    ..ultimum. Several compounds belonging to the thiourea series are able to inhibit selectively M. grisea at 50 and 10 microg mL(-1), doses at which the reference commercial compound tricyclazole had low or no effect...
  32. ncbi Sprouting and regeneration after pyramidotomy and blockade of the myelin-associated neurite growth inhibitors NI 35/250 in adult rats
    O Raineteau
    Brain Research Institute, University of Zurich, Switzerland
    Eur J Neurosci 11:1486-90. 1999
    ..tract (CST) at the level of the brainstem (pyramidotomy) and neutralization of the myelin associated neurite growth inhibitors NI-35/250 with the monoclonal antibody (mAb) IN-1, we had previously observed a strong behavioural recovery ..
  33. ncbi Growth, metabolism, and growth inhibitors of mesenchymal stem cells
    Deborah Schop
    Xpand Biotechnology BV, Bilthoven, The Netherlands
    Tissue Eng Part A 15:1877-86. 2009
    ..obtain more information about human MSCs regarding their expansion characteristics: growth, metabolism, and growth inhibitors. In addition, the same expansion factors were examined for (model species) goat and rat MSCs to evaluate ..
  34. ncbi RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer
    B S Finlin
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 276:42259-67. 2001
    ..These features of RERG are strikingly different from most Ras superfamily GTP-binding pro-teins and suggest that the loss of RERG expression may contribute to breast tumorigenesis...
  35. pmc Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation
    W P Schiemann
    Department of Pharmacology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 92:5361-5. 1995
    ..Thus, our results identify the human LIFR as a substrate for MAPK and suggest a mechanism of heterologous receptor regulation of LIFR signaling occurring at Ser-1044...
  36. ncbi Oncostatin M (OSM) inhibits the differentiation of pluripotent embryonic stem cells in vitro
    T M Rose
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Cytokine 6:48-54. 1994
    ..Competition binding studies demonstrate that OSM binds to the LIF receptor on MBL-5 ES cells. Our results implicate OSM as a developmental regulatory factor for embryonic stem cells in vivo...
  37. ncbi Are LIF and related cytokines functionally equivalent?
    C Piquet-Pellorce
    Department of Biochemistry, University of Oxford, United Kingdom
    Exp Cell Res 213:340-7. 1994
    ..These data suggest that OSM and LIF act on human cells through different receptors. Altogether, these results indicate that none of the factors examined in this study are precisely interchangeable in terms of their biological actions...
  38. ncbi Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A
    D Merkler
    Department of Neuromorphology, Brain Research Institute, , , Switzerland
    J Neurosci 21:3665-73. 2001
    ..These results indicating improved functional recovery suggest that the increased plastic and regenerative capabilities of the CNS after Nogo-A neutralization result in a functionally meaningful rewiring of the motor systems...
  39. ncbi Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium
    S Bauer
    Unité Mixte de Recherche 5020 Centre National de la Recherche Scientifique, Université Lyon I, 69622 Villeurbanne, France
    J Neurosci 23:1792-803. 2003
    ..Taken together, these results suggest that injured OSNs release LIF as a stimulus to initiate their own replacement...
  40. ncbi Regulation of cardiac fibroblast cellular function by leukemia inhibitory factor
    Feng Wang
    Winters Center for Heart Failure Research, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    J Mol Cell Cardiol 34:1309-16. 2002
    ..However, the effects of LIF in cardiac fibroblasts are not known. Given that the cardiac fibroblast is the most abundant cell type in the heart, we sought to examine the functional effects of LIF on cardiac fibroblasts in vitro...
  41. ncbi Leukemia inhibitory factor determines the growth status of injured adult sensory neurons
    W B Cafferty
    Centre for Neuroscience Research, Guy s, King s, and St Thomas School of Biomedical Science, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 21:7161-70. 2001
    ..LIF is also functionally protective to peptidergic sensory neurons after nerve damage in vivo. Our results indicate that the alteration in intrinsic growth status of injured sensory neurons depends, at least in part, on LIF...
  42. ncbi Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Res 61:5784-9. 2001
    ..These results support a therapeutic approach for the treatment of malignant gliomas devoid of psychotropic side effects...
  43. ncbi Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Toronto, Canada
    Neuron 30:65-78. 2001
    ..These results are consistent with a default mechanism for neural fate specification and support a model whereby definitive neural stem cell formation is preceded by a primitive neural stem cell stage during neural lineage commitment...
  44. ncbi Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells
    F Schroeder
    Department of Physiology and Pharmacology, Texas A and M University, TVMC, College Station 77843 4466, USA
    Mol Cell Biochem 219:127-38. 2001
    ..Taken together with the fact that L-FABP was detected in the nucleus, these data suggested that L-FABP may play a more direct, heretofore unknown, role in regulating ES cell differentiation by acting in the nucleus as well as cytoplasm...
  45. ncbi Epidermal growth factor receptors control competence to interpret leukemia inhibitory factor as an astrocyte inducer in developing cortex
    Jane Viti
    Department of Neurobiology and Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 23:3385-93. 2003
    ..EGFRs elevate STAT3 expression and increase its phosphorylation by LIF, but this is not sufficient to change LIF responsiveness to astrocyte induction, suggesting that EGFRs also regulate LIF responsiveness downstream of STAT3...
  46. ncbi Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling
    Ann M Turnley
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Nat Neurosci 5:1155-62. 2002
    ..These findings indicate that SOCS2 promotes neuronal differentiation by blocking growth hormone-mediated downregulation of Ngn1...
  47. ncbi Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines
    C Chaves-Dias
    Laboratory of Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:6647-56. 2001
  48. ncbi Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6
    Sowmya Viswanathan
    Institute of Biomaterials and Biomedical Engineering, Roseburgh Building, University of Toronto, 4 Taddle Creek Road, Toronto, Ontario, M5S 3G9, Canada
    Stem Cells 20:119-38. 2002
    ..Insights from these results may be more generally applicable to tissue-specific stem cells and could aid in the development of stem cell-based technologies...
  49. ncbi [Effects of SCF, LIF and bFGF on mouse spermatogonial stem cells proliferation in vitro]
    Ming Yin
    Quartermaster University of PLA, Changchun 050016, China
    Sheng Wu Gong Cheng Xue Bao 18:754-7. 2002
    ..01) of LIF, between 20 ng/mL and 50 ng/mL (P < 0.01) for bFGF. SCF and bFGF were significantly enhanced mice spermatogonial stem cells proliferation after these three factors combination. For LIF, no obvious effect was observed...
  50. ncbi GP130 stimulation and the maintenance of stem cells
    Stefan Rose-John
    Institut fur Biochemie, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Trends Biotechnol 20:417-9. 2002
    ..This article summarizes what is known about, and the problems associated with, the cultivation of stem cells and suggests experimental strategies that might help to overcome these difficulties...
  51. ncbi Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation
    Espen E Spangenburg
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Am J Physiol Cell Physiol 283:C204-11. 2002
    ..These data suggest that LIF induces satellite cell proliferation by activation of the JAK2-STAT3 signaling pathway, suggesting that this may be an important pathway in muscle growth and/or hypertrophy...
  52. ncbi Signalling, cell cycle and pluripotency in embryonic stem cells
    Tom Burdon
    Department of Gene Expression and Development, Roslin Institute, Midlothian, EH25 9PS, Roslin, UK
    Trends Cell Biol 12:432-8. 2002
    ..We relate these observations to the unusual cell-cycle properties of ES cells and speculate on the role of the cell cycle in maintaining pluripotency...
  53. ncbi Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells
    Takeshi Senga
    Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai Showa Nagoya 466 8550, Japan
    Oncogene 21:8186-91. 2002
    ..These results indicate that Stat3 mediates cellular growth by modulating AP-1 activity through the induction of BATF...
  54. pmc Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation
    Cheil Moon
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:9015-20. 2002
    ..Consequently, a population of ORNs is maintained in an immature state to facilitate the rapid repopulation of the olfactory epithelium with mature neurons during normal cell turnover or after injury...
  55. ncbi Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment
    Toshiaki Hayashi
    The Jerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cancer Ther 1:851-60. 2002
    ..These studies provide the rationale for clinical trials of As2O3, either alone or together with dexamethasone, to overcome classical drug resistance and improve outcome in patients with MM...
  56. ncbi Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes
    Ryoko Chinzei
    Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Hepatology 36:22-9. 2002
    ..In conclusion, our in vitro and in vivo experiments revealed that cultured EBs contain functional hepatocytes or hepatocyte-like cells...
  57. ncbi The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system
    Toshihisa Hatta
    Department of Anatomy, Shimane Medical University, Izumo 693 8501, Japan
    J Neurosci 22:5516-24. 2002
  58. ncbi Macrophage colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region
    Ken ichi Minehata
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Blood 99:2360-8. 2002
    ..These results suggest that M-CSF modulates the development of hematopoiesis by stimulating the differentiation of PCLP-1(+)CD45(-) cells to endothelial cells in the AGM region...
  59. ncbi Role of leukemia inhibitory factor in the regulation of the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Cell Physiol 192:315-26. 2002
    ..These results suggest that LIF is one of the keratinocyte-derived factors involved in regulating the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture in cooperation with cAMP elevator and bFGF...
  60. ncbi LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells
    Jan Jacob Schuringa
    Department of Developmental Genetics, Biological Center, Kerklaan 30, Haren, 9751 NN, The Netherlands
    Exp Cell Res 274:119-29. 2002
    ..The negative feedback protein suppressor of cytokine signaling 1 (SOCS-1) is constitutively expressed in N tera-2/D1 EC cells, suggesting that LIF signal transduction is inhibited by elevated levels of SOCS-1 expression...
  61. ncbi Decrease in apoptosis and increase in polyploidization of megakaryocytes by stem cell factor during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin
    Jeong Hae Kie
    Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea
    Stem Cells 20:73-9. 2002
    ..These results suggested that SCF not only inhibited premature senescence but also enhanced maturation of the differentiating cells of MK lineage during ex vivo expansion using TPO...
  62. pmc The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway
    Jong In Park
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cell Biol 23:543-54. 2003
    ..This use of multiple pathways may be important for "fail-safe" induction and maintenance of cell cycle arrest...
  63. ncbi Growth factor control of CNS myelination
    S K Park
    Department of Neurology, Beth Israel Deaconess Medical Center, Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    Dev Neurosci 23:327-37. 2001
  64. ncbi Influence of non-neuronal cells on establishment of neuropeptide Y expression by sympathetic neurons in vitro
    S E MacPhedran
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Dev Neurosci 23:307-17. 2001
    ..Together, these findings support the notion that the environment in which neurons become postmitotic contributes to neuronal phenotype...
  65. ncbi DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain
    T Takizawa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
    Dev Cell 1:749-58. 2001
    ..This CpG methylation leads to inaccessibility of STAT3 to the binding element. We suggest that methylation of a cell type-specific gene promoter is a pivotal event in regulating lineage specification in the developing brain...
  66. ncbi Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms
    F Blanchard
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 276:47038-45. 2001
    ..Proteosomal degradation appears to involve a fraction of receptor subunit proteins that are ubiquitinated independently of ligand binding...
  67. ncbi The protein tyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cell sprouting and induces growth arrest and apoptosis by inhibition of c-kit in AML cells
    Karsten Spiekermann
    Department of Medicine III, University Hospital Grosshadern, Clinical Cooperative Group Leukemia, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 30:767-73. 2002
    ..Angiogenesis, the process of new blood vessel formation, is a critical process during growth and metastasis of solid tumors and might also represent a promising therapeutical target in patients with acute myeloid leukemia (AML)...
  68. ncbi Leukemia inhibitory factor, interleukin-6, and their receptors are expressed transiently in the olfactory mucosa after target ablation
    B Nan
    Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Comp Neurol 435:60-77. 2001
    ..These data indicate that LIF from infiltrating macrophages acts as a mitogen for GBCs and that LIF from infiltrating macrophages and IL-6 from infiltrating macrophages and ensheathing cells act as repair factors in the ON...
  69. pmc Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc: role in leukemogenesis
    M Selvakumaran
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6059
    Mol Cell Biol 12:2493-500. 1992
    ..Taken together, these findings show that c-myb plays a key regulatory role in myeloid differentiation and substantiate the notion that deregulated expression of c-myb can play an important role in leukemogenicity...
  70. pmc Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis
    J Boer
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 18:1236-47. 1998
    ..These results confirm that CAN plays a crucial role in nucleocytoplasmic transport and imply an essential role for hCRM1 in cell growth and survival...
  71. ncbi Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts
    Michaela Kneissel
    Arthritis and Bone Metabolism Disease Area, Novartis Institutes for BioMedical Research Basel, Basel, Switzerland
    Bone 35:1144-56. 2004
    ..In conclusion, everolimus directly inhibits bone resorption by osteoclasts and thus could at least be neutral or protective for bone in vivo, which would favor its use in disease indications associated with bone loss...
  72. ncbi OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:1433-7. 2005
    ..This would serve to limit inappropriate T cell responses. In contrast, OX40 signals from CD4(+)CD3(-) cells located in the outer T zone select proliferating Th2 effectors into the memory T cell pool...
  73. ncbi Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2071-83. 2005
    ..Collectively, these findings firmly establish for the first time that TGF-beta1 discriminately regulates CD4+ and CD8+ T cell expansion by signaling through distinct intracellular pathways...
  74. pmc Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells
    H Boeuf
    Institut de Génétique et de Biologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Medicale Université Louis Pasteur, F 67404 Illkirch Cedex C U de Strasbourg, France
    J Cell Biol 138:1207-17. 1997
    ..Our results suggest that STAT3 is a critical target of the LIF signaling pathway, which maintains pluripotent cell proliferation...
  75. ncbi Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
    S Minamoto
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Biochem Biophys Res Commun 237:79-83. 1997
    ..We also demonstrated the structure of human SSI-1...
  76. pmc Contrasting responses of lymphoid progenitors to canonical and noncanonical Wnt signals
    Sachin Malhotra
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:3955-64. 2008
    ..We conclude that at least two Wnt ligands can differentially regulate early events in B lymphopoiesis, affecting entry and progression in distinct differentiation lineages...
  77. ncbi Dobesilate inhibits the activation of signal transducer and activator of transcription 3, and the expression of cyclin D1 and bcl-XL in glioma cells
    P Cuevas
    Departamento de Investigacion, Hospital Universitario Ramon y Cajal, Universidad de Alcala de Henares, Madrid, Spain
    Neurol Res 28:127-30. 2006
    ..Because STAT3 signaling pathway plays pleiotropic roles in tumor proliferation, maintenance of STAT3 in its inactive state may prevent glioma growth and spreading...
  78. ncbi The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor
    H H Nandurkar
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Oncogene 12:585-93. 1996
    ..Introduction of human gp130 into these cells resulted in high-affinity IL-11 binding sites and IL-11 dependent cellular proliferation. Thus these results demonstrated the absolute requirement of gp130 for signalling...
  79. ncbi Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells
    Xue Zhong Yu
    Immunology and Blood and Marrow Transplantation Programs, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Immunol 176:7394-401. 2006
    ..Our findings indicate that ICOS has paradoxical effects on the regulation of alloreactive CD4(+) and CD8(+) T cells in GVHD...
  80. ncbi The effects of fibroblast growth factors in long-term primary culture of dystrophic (mdx) mouse muscle myoblasts
    J Smith
    Department of Anatomy, University of Cambridge, United Kingdom
    Exp Cell Res 210:86-93. 1994
    ..A major difference observed between dystrophic and normal skeletal muscle explants was the reduction in fibroblast-like cell outgrowth of dystrophic explants...
  81. pmc The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth
    Q Zhan
    Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892
    Mol Cell Biol 14:2361-71. 1994
    ..Taken together, these observations indicate that these genes define a novel class of mammalian genes encoding acidic proteins involved in the control of cellular growth...
  82. ncbi Tumor necrosis factor-alpha (TNF-alpha) stimulates proliferation of mouse primordial germ cells in culture
    E Kawase
    Mammalian Development Laboratory, National Institute of Genetics, Mishima, Japan
    Dev Biol 161:91-5. 1994
    ..A previously reported finding that TNF-alpha is expressed at these stages in mouse embryos suggests possible involvement of TNF-alpha in the proliferative regulation of the PGCs in the embryo...
  83. ncbi Methylcobalamin inhibits fibroblast growth factor-8 stimulated proliferation and induces apoptosis in Shionogi carcinoma cells
    Greicy H Goto
    Dept of Pathology, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3 3 Nakamichi 1 Chome, Higashinari, Osaka, Japan
    Int J Vitam Nutr Res 78:21-6. 2008
    ..These results show that the addition of FGF-8 stimulates the proliferation of SC-3 cells under the androgen-depleted condition and that MeCbl might be able to interfere with FGF-8 action...
  84. ncbi Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation
    Jonathan M Dermott
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702 1201, USA
    Stem Cells 22:832-48. 2004
    ..We propose that during myelomonocytic cell differentiation, induction of p205 expression contributes to cell growth arrest, thus allowing progenitor cells to differentiate...
  85. ncbi Oncostatin M-specific receptor expression and function in regulating cell proliferation of normal and malignant mammary epithelial cells
    J Liu
    Department of Veterans Affairs Medical Center, Mountain States Medical Research Institute, Boise, Idaho 83702, USA
    Cytokine 10:295-302. 1998
    ..Together, these data suggest that OSM plays an inhibitory role in normal and malignant mammary epithelial cell growth in vitro. OSM activity is mediated by the OSM-specific receptor (type II), not by the OSM/LIF shared receptor...
  86. ncbi NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes
    Miklos Geiszt
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:299-306. 2003
  87. ncbi Adult bone marrow stromal cells differentiate into neural cells in vitro
    J Sanchez-Ramos
    Department of Neurology, University of South Florida, Tampa, USA
    Exp Neurol 164:247-56. 2000
    ..When labeled human or mouse BMSC were cultured with rat fetal mesencephalic or striatal cells, a small proportion of BMSC-derived cells differentiated into neuron-like cells expressing NeuN and glial cells expressing GFAP...
  88. ncbi Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells
    N Tanuma
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    J Biol Chem 275:28216-21. 2000
    ..These results suggest an important role for PTPepsilonC in negative regulation of IL-6- and LIF-induced Jak-STAT signaling...
  89. ncbi Stimulation of primary human endothelial cell proliferation by IFN
    Dolores Gomez
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    J Immunol 170:5373-81. 2003
    ..These results reveal changes in the RNA levels of genes in endothelial cells that encode proteins involved in cellular proliferation...
  90. ncbi Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen
    J D Richards
    Department of Microbiology and Immunology, G. W. Hooper Foundation, University of California, San Francisco, CA 94143, USA
    J Immunol 166:3855-64. 2001
    ..Moreover, both inhibitors suppressed BCR-induced proliferation of mature splenic B cells, in the absence and in the presence of IL-4. Therefore, activation of the MEK-ERK pathway is necessary for a subset of B cell responses to Ag...
  91. ncbi Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis
    R Pili
    The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 61:1477-85. 2001
    ..004 versus single agents). In summary, this study showed an additive inhibitory effect of combination of differentiation agents PB and CRA on prostate tumor growth through a direct effect on both tumor and endothelial cells...
  92. ncbi Gene expression in human neural stem cells: effects of leukemia inhibitory factor
    Lynda S Wright
    The Waisman Center Stem Cell Research Program and Department of Anatomy, University of Wisconsin, 53705, USA
    J Neurochem 86:179-95. 2003
    ..This study provides the first molecular profile of human ltNSCctx cultures capable of long-term self renewal, and reveals specific sets of genes that are directly or indirectly regulated by LIF...
  93. ncbi Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction
    Yunzeng Zou
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Circulation 108:748-53. 2003
    ..Myocardial infarction (MI) is a leading cause of cardiac morbidity and mortality in many countries; however, the treatment of MI is still limited...
  94. ncbi NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy
    Yoshihiro Hayakawa
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 172:123-9. 2004
    ..These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC...
  95. ncbi Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
    Yulia Nefedova
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 172:464-74. 2004
    ..Thus, this is a first demonstration that tumor-derived factors may affect myeloid cell differentiation in cancer via constitutive activation of Jak2/STAT3...
  96. ncbi Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background
    Jonathan C Poe
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 172:2100-10. 2004
    ..Moreover, this study defines CD22 and CD40 as the first examples of lymphocyte coreceptors that influence induction of the c-Myc:CUL1 ubiquitin ligase pathway...
  97. ncbi Astrocyte differentiation mediated by LIF in cooperation with BMP2
    K Nakashima
    Department of Molecular Cell Biology, Tokyo Medical and Dental University, Japan
    FEBS Lett 457:43-6. 1999
  98. ncbi Plant growth inhibition by cis-cinnamoyl glucosides and cis-cinnamic acid
    Syuntaro Hiradate
    Department of Biological Safety Science, National Institute for Agro Environmental Sciences, Tsukuba, Ibaraki 305 8604, Japan
    J Chem Ecol 31:591-601. 2005
    ..Phleum pratense), and bok choy (Brassica rapa var chinensis) in comparison with that of two well-known growth inhibitors, 2,4-dichlorophenoxyacetic acid (2,4-D) and (+)-2-cis-4-trans-abscisic acid (cis-ABA), as well as two ..
  99. ncbi United States Department of Agriculture-Agricultural Research Service research on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops
    Thomas E Cleveland
    US Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA 70124, USA
    Pest Manag Sci 59:629-42. 2003
    ..of certain trichothecenes, thereby helping reduce fungal virulence, or (2) contain genes encoding fungal growth inhibitors for reducing fungal infection...
  100. ncbi Identification, purification and characterization of a putative novel growth-inhibitory and/or apoptotic protein from rat liver
    S S Dadke
    Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 84:14-20. 1998
    AIMS AND BACKGROUND: The existence of endogenous growth inhibitors was postulated in 1914 by Boveri...
  101. ncbi In vitro antiproliferative effects of neuroleptics, antimycotics and antibiotics on the human pathogens Acanthamoeba polyphaga and Naegleria fowleri
    Center for Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Arch Med Res 37:723-9. 2006

Research Grants63

  1. Regulatory Circuits Controlling Development of Dormant Microbial Cysts
    CARL EUGENE BAUER; Fiscal Year: 2013
    ..Cysts are metabolically dormant resting cells that are extremely resistant to desiccation as well as to growth inhibitors such as to antibiotics. This study analyzes cyst formation in the gram-negative model organism R...
  2. Novel approaches to develop a treatment for cryptosporidiosis
    Christopher D Huston; Fiscal Year: 2013
    ..parvum growth inhibitors in combination with low dose nitazoxanide...
    ALAN CARL LEONARD; Fiscal Year: 2013 will also aid in the identification of new targets appropriate to guide the design of novel cell growth inhibitors for bacterial pathogens...
  4. Structures of Mtb proteins conferring susceptibility to known Mtb inhibitors
    James C Sacchettini; Fiscal Year: 2013
    ..We will accomplish this by identifying proteins that are targeted by whole cell growth inhibitors of Mtb discovered by a recently conducted high-throughput screen of over 200,000 drug-like small molecules...
    ROGER LAINE; Fiscal Year: 1993
    ..important biological activities, such as virus and microbial host cell surface receptors, smooth muscle cell growth inhibitors and others. The area has grown in importance to the level where recombinant DNA was perhaps 10 years ago...
  6. Using Drosophila for in vivo drug screens to selectively target cancer stem cells
    Norbert Perrimon; Fiscal Year: 2010
    ..Our goal is to focus on growth inhibitors that specifically affect the CSCs and not wildtype stem cells, and drugs that specifically target the Notch ..
    VENUDHAR REDDY; Fiscal Year: 1999
    ..Our initial findings show that several 1,2-naphthoquinone derivatives are extremely effective growth inhibitors of T. vaginalis...
    GREGORY HELM; Fiscal Year: 1999 replace lost neural populations, and the use of antibodies directed against myelin-associated neurite growth inhibitors to improve axonal regeneration...
  9. Long distance nerve regeneration via processed allografts in a caprine model
    Richard Johnson; Fiscal Year: 2007
    ..i) structural preservation of the graft and (ii) cellular removal and complete degradation of CSPG nerve growth inhibitors post-processing...
  10. Anticancer Agents: Structure and Synthesis
    Amos B Smith; Fiscal Year: 2012
    ..rare marine agents that possess activities similar to Gleevec, and (E) with a total synthesis of tumor cell growth inhibitors (+)-neopeltolide, exploiting the Petasis-Ferrier tactic not only to construct the requisite tetrahydropyran ..
    George Michalopoulos; Fiscal Year: 1993
    ..aims to characterize the response of normal and neplastic human hepatocytes to these growth factors and growth inhibitors such as TGFbeta and IL-6...
    KENNETH GABBAY; Fiscal Year: 2000
    ..between actions of growth simulators such as growth hormone (GH) and insulin-like growth factors (IGFs), and growth inhibitors. In normal sera, IGF binds IGF binding protein (IGFBP)-3 and acid-labile subunit (ALS) in a large complex; ..
  13. Post-Stroke Blockade of Axonal Growth Inhibitors to Promote Functional Repair
    JUSTINE OVERMAN; Fiscal Year: 2010
    ..Axonal growth inhibitors block neuronal sprouting and functional recovery in other models of CMS injury, such as spinal cord injury ..
    Tongwen Wang; Fiscal Year: 1999
    ..They also act as tissue and cell specific growth inhibitors, thus making them candidate tumor suppressors...
    DHAN KALVAKOLANU; Fiscal Year: 2001
    Interferons (IFNs) and retinoids are powerful biological response modifiers. Although they are effective growth inhibitors of certain transformed cells, both these agents have limited efficacy as single agents against many tumors...
    Andrei Gudkov; Fiscal Year: 2004
    ..of the bystander effect, suggesting that kinesin participates in p53-dependent stress-induced secretion of growth inhibitors. Current program is devoted to characterization of the role of stress-induced bystander effect in tumor ..
    RALPH KEIL; Fiscal Year: 1999
    ..We have shown that volatile anesthetics inhibit yeast growth and that the action of these compounds as yeast growth inhibitors parallels their actions as agents for inducing anesthesia...
    Nezam Afdhal; Fiscal Year: 2002
    ..2) Characterize how mucin effects the morphology and rate of crystal growth in solution and in gels so that growth inhibitors can eventually be developed; 3) Examine the central role of mucin as the matrix protein in the ..
    STEPHEN BARTELMEZ; Fiscal Year: 1999
    ..Specifically, we plan: a) to define the specific growth conditions [e.g., growth factors, growth inhibitors, adhesion molecules/ligands ("adhesins")] that control the maintenance of "sternness" of long-term ..
    Margarida Barroso; Fiscal Year: 2002 cell migration and cell polarity as well as of abnormal processes like tumor cell response to both growth inhibitors and stimulators, which have been shown to be mediated by dynamic and complex interactions between ..
  21. Molecular Determinants of Adult CNS Axonal Growth
    Stephen M Strittmatter; Fiscal Year: 2010
    ..Members of the ephrin, RGM and Sema protein families are candidate adult CNS axonal growth inhibitors. We will utilize specific genetic tools to assess their role in vivo in limiting axonal growth and recovery ..
    Masato Koreeda; Fiscal Year: 1980
    ..hormones, and study their biological activities using insects with a view towards producing possible insect growth inhibitors; (3) to establish the stereochemical course of the enzymatic oxidation reaction of steroid methyl groups ..
    Jeanette McNeill; Fiscal Year: 1991 CNS, phosphoseryl peptides, bioactive peptide hormones, unknown sphingoid bases, phospholipids, uremic growth inhibitors, enzymes involved in neurohormone synthesis, flavoenzymes, and the anion exchange membrane protein band 3...
    Brian Carr; Fiscal Year: 1992
    ..Its great interest is that very few purified, naturally-occurring growth inhibitors have been so far identified in animal tissues...
    Benjamin Leung; Fiscal Year: 1992
    ..proposal aimed at elucidating this mechanism by investigating the relationship of growth factors (GFs) and growth inhibitors (GIs) to normal fetal growth and alcohol-induced IUGR...
  26. Menaquinone biosynthesis: a drug target in Gram-positive bacteria
    Dean Crick; Fiscal Year: 2007
    ..via cycle of synthetic medicinal chemistry followed by evaluation of compounds as menaquinone, and bacterial growth inhibitors. The compounds will also be counter-selected to reduce their effectiveness as cholesterol synthesis ..
    Ann Marie Pendergast; Fiscal Year: 2003 the oncogenic BCR-ABL tyrosine kinases constitutes a novel mechanism for the functional inactivation of growth inhibitors/tumor suppressors, and 2) to identify intracellular signaling pathways that are differentially regulated by ..
    Benjamin Leung; Fiscal Year: 1990 used to evaluate the effects of estrogen and anti-estrogens on the synthesis of growth factors (GFs) and growth inhibitors (GIs), the effects of GFs and GIs on tumor growth with and without estrogen, and the effects of estrogen and ..
  29. PTEN and Perlecan in Reducing In-Stent Restenosis
    Mary Weiser Evans; Fiscal Year: 2007
    ..of the tumor suppressor PTEN and the heparan sulfate-rich subdomains of perlecan, two endogenous SMC growth inhibitors, using a localized, stent-based delivery of adenovirus will effectively inhibit in-stent neointima formation...
    VENUDHAR REDDY; Fiscal Year: 1999
    ..evidence, according to the investigators, indicates that polyamine analogs have been successfully used as growth inhibitors of several pathogenic protozoa...
  31. Cell Autonomy and Tumor Suppression by CDK inhibitors
    Matthew Fero; Fiscal Year: 2009
    Models of tumor suppression by cell cycle growth inhibitors commonly assume that the critical inhibitory activity is intrinsic to the tumor clone...
  32. Accelerated senescence in tumor cells
    IGOR RONINSON; Fiscal Year: 2005
    ..Senescent cells also showed increased expression of many intracellular and secreted growth inhibitors, as well as secreted mitogenic and angiogenic factors, proteases, extracellular matrix components and ..
    John Wang; Fiscal Year: 1992
    ..These latter studies should, in turn, contribute to our understanding of the general biological significance of endogenous growth inhibitors in cellular homeostasis.
  34. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  35. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
  36. K Vitamins- A New Class of Liver Cell Growth Inhibitors
    Brian Carr; Fiscal Year: 2008
    ..unreadable] [unreadable]..
    Se Jin Lee; Fiscal Year: 2005
    ..abstract_text> ..
  38. Cell-targeting peptide nucleic acids for hormone-refractory prostate cancer
    Beverly Barton; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2007
    ..abstract_text> ..
    Jean Pierre Perchellet; Fiscal Year: 2004
    ..abstract_text> ..
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  42. Immunogenic epitopes of rare HIV mutants as vaccines
    Sylvie Blondelle; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. Anti-Cancer Activities of PTPase Inhibitors
    Taolin Yi; Fiscal Year: 2007
    ..abstract_text> ..
  44. PTPases as Therapeutic Targets
    Taolin Yi; Fiscal Year: 2005
    Maya Sieber Blum; Fiscal Year: 2004
    ..Both types of drug easily cross the placenta and can cause autonomic disturbances in infants born to mothers who have been treated with the antidepressant, or who have used cocaine during pregnancy. ..
  46. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
    ..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
  47. Lysine decarboxylase in periodontitis patients
    Martin Levine; Fiscal Year: 2004
    ..abstract_text> ..
    JOHN BIXBY; Fiscal Year: 2001
    ..In addition, these results will bear on the mechanism of regeneration after nervous system injury. ..
    Sumner Burstein; Fiscal Year: 2002
    ..abstract_text> ..
  50. In Situ Detection of Host-Spirochete Interaction by Iso*
    Ruth Montgomery; Fiscal Year: 2002
    ..burgdorferi. In summary, this proposal employs a novel and powerful technique to address several possible mechanisms of spirochetal evasion of the immune system. ..
  51. A Zeiss LSM 510 Confocal Microscope for Medical Research
    Ruth Montgomery; Fiscal Year: 2004
    ..Thus this confocal microscope would be the basis of a core facility to assure that these investigators will have adequate access to state-of-the-art imaging techniques. ..
  52. Angiogenesis:Novel Basic Science Insight & Human Therapy
    Napoleone Ferrara; Fiscal Year: 2004
    ..abstract_text> ..
    Ramaswamy Kalyanasundaram; Fiscal Year: 2004
    ..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
    Patrick Wen; Fiscal Year: 2008
    ..abstract_text> ..
  55. Determinants of Response to ZD1839
    Manuel Hidalgo; Fiscal Year: 2007
    ..These results will provide important information for the rationale clinical development of this class of novel agents based on biologic and mechanistic data. ..
    RONALD SCHNAAR; Fiscal Year: 2004
  57. Role of Myelin in Spinal Cord Regeneration
    Marie Filbin; Fiscal Year: 2008
    ..Through these studies a molecular insight will be gained into encouraging axons to regenerate in vivo and possible therapies may be identified. ..