fibroblast growth factor 2

Summary

Summary: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Top Publications

  1. ncbi Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    Lei Yang
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 453:524-8. 2008
  2. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
  3. pmc Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells
    Hiroshi Kubota
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:16489-94. 2004
  4. ncbi Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
    Marco Presta
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Cytokine Growth Factor Rev 16:159-78. 2005
  5. ncbi Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells
    Panagiota A Sotiropoulou
    Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, 171 Alexandras Avenue, 115 22, Athens, Greece
    Stem Cells 24:462-71. 2006
  6. ncbi BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    Marion Scharpfenecker
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Sci 120:964-72. 2007
  7. pmc Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
    Linlin Wang
    Division of Hematology, Department of Medicine, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, 98195, USA
    Blood 110:4111-9. 2007
  8. pmc Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
    Ludovic Vallier
    Department of Surgery and Laboratory For Regenerative Medicine, West Forvie Building, Robinson Way, University of Cambridge, Cambridge CB2 0SZ, UK
    Development 136:1339-49. 2009
  9. pmc A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells
    Livia Eiselleova
    Department of Biology, Faculty of Medicine University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Stem Cells 27:1847-57. 2009
  10. ncbi Basic fibroblast growth factor support of human embryonic stem cell self-renewal
    Mark E Levenstein
    WiCell Research Institute, P O Box 7365, Madison, Wisconsin 53707 7365, USA
    Stem Cells 24:568-74. 2006

Detail Information

Publications397 found, 100 shown here

  1. ncbi Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    Lei Yang
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 453:524-8. 2008
    ..Together, these findings identify a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development...
  2. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
    ..These findings suggest that alpha v beta 3 may be a useful therapeutic target for diseases characterized by neovascularization...
  3. pmc Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells
    Hiroshi Kubota
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:16489-94. 2004
    ..Moreover, the ability to recover, culture indefinitely, and transplant SSCs will make the germ-line of individual males available for periods extending beyond a normal lifetime...
  4. ncbi Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
    Marco Presta
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Cytokine Growth Factor Rev 16:159-78. 2005
    ..Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization...
  5. ncbi Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells
    Panagiota A Sotiropoulou
    Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, 171 Alexandras Avenue, 115 22, Athens, Greece
    Stem Cells 24:462-71. 2006
    ..In conclusion, in this report we define the optimal culture conditions for the successful isolation and expansion of human MSCs in high numbers for subsequent cellular therapeutic approaches...
  6. ncbi BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    Marion Scharpfenecker
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Sci 120:964-72. 2007
    ..Taken together, these results suggest that BMP-9 is a physiological ALK1 ligand that plays an important role in the regulation of angiogenesis...
  7. pmc Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
    Linlin Wang
    Division of Hematology, Department of Medicine, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, 98195, USA
    Blood 110:4111-9. 2007
    ..These studies identify previously unappreciated RTKs that support hESC proliferation and self-renewal, and provide a rationally designed medium for the growth and maintenance of pluripotent hESCs...
  8. pmc Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
    Ludovic Vallier
    Department of Surgery and Laboratory For Regenerative Medicine, West Forvie Building, Robinson Way, University of Cambridge, Cambridge CB2 0SZ, UK
    Development 136:1339-49. 2009
    ..This negative-feedback loop imposes stasis in neuroectoderm and mesendoderm differentiation, thereby maintaining the pluripotent status of human ESCs and mouse EpiSCs...
  9. pmc A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells
    Livia Eiselleova
    Department of Biology, Faculty of Medicine University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Stem Cells 27:1847-57. 2009
    ..This stimulation of self-renewal, cell survival, and adhesion by exogenous and endogenous FGF-2 may synergize to maintain the undifferentiated growth of hESCs...
  10. ncbi Basic fibroblast growth factor support of human embryonic stem cell self-renewal
    Mark E Levenstein
    WiCell Research Institute, P O Box 7365, Madison, Wisconsin 53707 7365, USA
    Stem Cells 24:568-74. 2006
    ..These results further facilitate the large-scale, routine culture of human ES cells and suggest that fibroblasts and fibro-blast-conditioned medium sustain human ES cells in part by stabilizing FGF signaling above a critical threshold...
  11. pmc Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels
    Wen Tzu Lai
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Stem Cells 29:1102-11. 2011
    ..Previously, we reported that fibroblast growth factor 2 (Fgf2) reversibly inhibited multilineage differentiation of primary mouse MSCs and now identify a unique ..
  12. pmc Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
    Mohamed Izikki
    INSERM U841, Faculte de Medecine, 8 Avenue du General Sarrail, 94010 Creteil, France
    J Clin Invest 119:512-23. 2009
    ..Thus, endothelial FGF2 is overproduced in IPH and contributes to SMC hyperplasia in IPH, identifying FGF2 as a promising target for new treatments against PH...
  13. ncbi Feeder layer- and serum-free culture of human embryonic stem cells
    M Amit
    Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Biol Reprod 70:837-45. 2004
    ..The feeder layer-free culture system reported here aims at facilitating research practices and providing a safer alternative for future clinical applications of hES cells...
  14. ncbi FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells
    Luis A Solchaga
    Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Cell Physiol 203:398-409. 2005
    ..With the generation of gene expression profiles of FGF-treated and control cells we have taken the first steps in the elucidation of the molecular mechanism(s) behind these phenomena...
  15. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
    ..Bone marrow cell therapy is reported to contribute to collateral formation through cell incorporation into new or remodeling vessels. However, the possible role of a paracrine contribution to this effect is less well characterized...
  16. ncbi Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis
    Marjorie Pick
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria 3800, Australia
    Stem Cells 25:2206-14. 2007
    ..These data demonstrate the utility of the serum-free spin EB system in dissecting the roles of specific growth factors required for the directed differentiation of HESCs toward the hematopoietic lineage...
  17. pmc FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
    Pengzhi Yu
    Morgridge Institute for Research, Madison, WI 53715 7365, USA
    Cell Stem Cell 8:326-34. 2011
    ..Together, our results demonstrate that FGF2 signaling switches the outcome of BMP4-induced differentiation of human ESCs by maintaining NANOG levels through the MEK-ERK pathway...
  18. ncbi Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
    Roger G Fahmy
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Nat Med 9:1026-32. 2003
    ..Egr-1 DNAzymes also repressed neovascularization of rat cornea. Thus, microvascular endothelial cell growth, neovascularization, tumor angiogenesis and tumor growth are processes that are critically dependent on Egr-1...
  19. pmc Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells
    Man Tat Lau
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e59083. 2013
    b>Fibroblast growth factor 2 (FGF2) is produced by ovarian cancer cells and it has been suggested to play an important role in tumor progression...
  20. ncbi Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders
    M Takebayashi
    Department of Psychiatry, National Hospital Organization NHO Kure Medical Center, 3 1 Aoyama, Kure 737 0023, Japan
    J Neural Transm 117:1119-22. 2010
    ..Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD...
  21. ncbi Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
    Yasunobu Sawaji
    Imperial College London, London, UK
    Arthritis Rheum 58:3498-509. 2008
    Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage.
  22. ncbi Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library
    Satoko Ashikari-Hada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 279:12346-54. 2004
    ..Thus, the library may provide new reagents to specifically regulate bindings of the growth factors to HS...
  23. ncbi Basic fibroblast growth factor: increased gene expression in inherited and light-induced photoreceptor degeneration
    H Gao
    Division of Ophthalmology, Research Institute FFb, Cleveland, OH 44195, USA
    Exp Eye Res 62:181-9. 1996
    ..We speculate that endogenous bFGF may function as a photoreceptor protection/rescue factor that is activated in response to photoreceptor stress...
  24. ncbi Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2
    Giordano Bianchi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Exp Cell Res 287:98-105. 2003
    ..Here we report that fibroblast growth factor 2 (FGF-2)-supplemented bone marrow stromal cell primary cultures display an early increase in telomere ..
  25. pmc FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability
    Frederique M D Tholozan
    School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, United Kingdom
    Mol Biol Cell 18:4222-31. 2007
    ..The lens capsule is also a source of soluble factors including fibroblast growth factor 2 (FGF-2) and perlecan, an extracellular matrix component that enhances FGF-2 activity...
  26. pmc Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    Kan Ding
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
    J Cell Biol 171:729-38. 2005
    ..These results support a specific role for shed syndecan-1 or MMP7-syndecan-1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo...
  27. ncbi Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF
    S Tsutsumi
    Japan Science and Technology Corporation (JST, Chiyodaku, Tokyo 102-8666, Japan
    Biochem Biophys Res Commun 288:413-9. 2001
    ..The FGF+ MSC also retained the osteogenic and adipogenic potential throughout many mitotic divisions. These findings suggest that FGFs play a crucial role in self-renewal of MSC...
  28. ncbi Effects of angiogenic growth factor combinations on retinal endothelial cells
    Raquel Castellon
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School Affiliate, Los Angeles, CA 90048, USA
    Exp Eye Res 74:523-35. 2002
    ..Their effects, however, can be greatly augmented by other growth factors that alone exert little or no action. Therefore, diabetic retinal neovascularization may result from the additive or synergistic action of several growth factors...
  29. ncbi Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes
    Mojca Globocnik Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Clin Experiment Ophthalmol 36:168-72. 2008
    ..The second aim was to determine whether serum levels of bFGF are affected by genetic factors...
  30. ncbi Expression of bone morphogenetic protein 2 and fibroblast growth factor 2 during bone regeneration using different implant materials as an onlay bone graft in rabbit mandibles
    Shamiul Alam
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa and Toyama, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:16-26. 2007
    ....
  31. ncbi Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation
    Zhifeng Xiao
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Cell Res 17:73-9. 2007
    ..Collectively, this study may provide insight into the mechanisms by which microenvironmental niche signals regulate NSCs...
  32. ncbi A [polycation:heparin] complex releases growth factors with enhanced bioactivity
    Hunghao Chu
    Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Control Release 150:157-63. 2011
    ..PEAD:heparin] appears to be a promising delivery matrix for many heparin-binding growth factors and may lead to efficient growth factor delivery for a variety of diseases and disabilities...
  33. ncbi Interactions between extracellular matrix and growth factors in wound healing
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, 32610 0294, USA
    Wound Repair Regen 17:153-62. 2009
    ..Thus, the interactions between growth factors and ECM are bidirectional. This review explores these interactions, discusses how they are altered in difficult to heal or chronic wounds, and briefly considers treatment implications...
  34. ncbi A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    Kimita Suyama
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Cell 2:301-14. 2002
    ..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...
  35. ncbi Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate
    Toshikazu Shiba
    Frontier Research Division, Fujirebio Inc, 51, Komiya, Hachioji, Tokyo 192 0031, Japan
    J Biol Chem 278:26788-92. 2003
    ..Furthermore, poly(P) facilitated the FGF-2 binding to its cell surface receptors. Because poly(P) is widely distributed in mammalian tissues, it may be a spontaneous modulator of FGFs...
  36. ncbi Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing
    Ju Lin Xie
    Department of Burns, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Wound Repair Regen 16:576-81. 2008
    ..The evidence should contribute to a better understanding of the biological activities of bFGF during hypertrophic scar formation...
  37. ncbi Vascular endothelial growth factor synthesis by human omental mesothelial cells is augmented by fibroblast growth factor-2: possible role of mesothelial cell on the development of peritoneal metastasis
    Akihiro Sako
    Department of Surgery, Division of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Surg Res 115:113-20. 2003
    ..These data suggest that HPMC contribute to the development of metastases and the accumulation of malignant ascites due to the production of VEGF, especially in cancers that do not express enough amount of VEGF...
  38. ncbi Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation
    Jonathan Lu
    Department of Medicine, Baylor College of Medicine, 6565 Fannin St, MS A 601, Houston, TX 77030, USA
    Diabetes 57:158-66. 2008
    ..FGF2 plays a pivotal role in endothelial regeneration and compensatory arteriogenesis. It is likely that vasculopathy and poor collateralization in diabetes is a result of FGF2 dysregulation...
  39. ncbi Dexamethasone inhibits basic fibroblast growth factor-stimulated gastric epithelial cell proliferation
    Jiing Chyuan Luo
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochem Pharmacol 76:841-9. 2008
    ....
  40. ncbi Enrichment and differentiation of human germ-like cells mediated by feeder cells and basic fibroblast growth factor signaling
    Franklin D West
    Department of Animal and Dairy Science, Regenerative Bioscience Center, University of Georgia, Athens, Georgia 30602, USA
    Stem Cells 26:2768-76. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  41. ncbi Expression and functions of fibroblast growth factor 2 (FGF-2) in hippocampal formation
    Sabrina Zechel
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroscientist 16:357-73. 2010
    ..The focus of this review is on the expression of FGF-2 and its receptors in the hippocampal formation and the physiological and pathophysiological roles of FGF-2 in this region during development and adulthood...
  42. ncbi Identification of growth and attachment factors for the serum-free isolation and expansion of human mesenchymal stromal cells
    Sunghoon Jung
    Pharmaceutical Production Research Facility PPRF, Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada
    Cytotherapy 12:637-57. 2010
    ..Therefore a major step forward would be the identification of defined, serum-free culture conditions capable of supporting both the isolation and rapid expansion of hMSC...
  43. ncbi Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells
    Laure Emmanuelle Zaragosi
    Institut de Recherche, Signalisation, Biologie du Développement et Cander, UMR6543 Centre National de la Recerche Scientifique, Centre de Biochimie, Faculte des Sciences, Université Nice Sophia Antiplis, Nice, France
    Stem Cells 24:2412-9. 2006
    ..This decrease is associated with a decrease in fibroblast growth factor 2 (FGF2) expression and can be circumvented by chronic treatment with exogenous FGF2...
  44. pmc Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span
    Riccardo E Nisato
    Department of Morphology, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Am J Pathol 165:11-24. 2004
    ..The production and characterization of hTERT-HDLEC will facilitate the study of the properties of lymphatic endothelium in vitro...
  45. ncbi Roles of exogenous and endogenous FGF-2 in animal models of depression
    J Jarosik
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, Heidelberg, Germany
    Restor Neurol Neurosci 29:153-65. 2011
    ..Several members of the fibroblast growth factor (FGF) family have been shown to be dysregulated in individuals with major depression, and treatment with antidepressants has been reported to increase FGF-2 mRNA levels in the forebrain...
  46. pmc Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression
    Sandra I Zittermann
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Pathol 168:835-46. 2006
    ..Thus, although not directly proinflammatory, bFGF synergistically potentiates inflammatory mediator-induced leukocyte recruitment, at least in part, by enhancing CAM up-regulation on endothelium...
  47. ncbi Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression
    Hitomi Eto
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Lab Invest 92:214-23. 2012
    ..Decreased MMP-1 expression may be an important transcriptional change in HTS, and its reversal as well as upregulation of HGF by FGF-2 could be a new therapeutic approach for HTS...
  48. ncbi Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor
    Julia Jungnickel
    Department of Neuroanatomy OE 4140, Center of Anatomy, Hannover Medical School, D 30623 Hannover, Germany
    J Neurobiol 66:940-8. 2006
    ..We propose that endogenously synthesized FGF-2 influences early peripheral nerve regeneration by regulating Schwann cell proliferation, axonal regrowth, and remyelination...
  49. pmc Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid
    Sayaka Ono
    Bioscience and Biotechnology Center and the Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 287:3710-22. 2012
    ..Taken together, these results suggest that polySia-NCAM might be involved in the regulation of FGF2-FGF receptor signaling through the direct binding of FGF2 in a manner distinct from heparan sulfate...
  50. pmc A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation
    Vanesa Nieto-Estévez
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    PLoS ONE 8:e53594. 2013
    ....
  51. pmc Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis
    Daria Leali
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Arterioscler Thromb Vasc Biol 32:696-703. 2012
    ..b>Fibroblast growth factor 2 (FGF2) is a major proangiogenic inducer inhibited by the interaction with the soluble pattern ..
  52. ncbi Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2
    Nadine Thau
    Hannover Medical School, Department of Neurology, Hannover, Germany
    Neurobiol Dis 47:248-57. 2012
    ..Basic fibroblast growth factor 2 (FGF-2) plays a prominent role in the motor system...
  53. pmc Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells
    Borzo Gharibi
    Department of Periodontology, King s College London, London, UK
    Stem Cells Transl Med 1:771-82. 2012
    ..Loss of differentiation potential was not reflected by changes in stem cell surface marker expression...
  54. ncbi Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting
    Annamaria Naggi
    G Ronzoni Institute for Chemical and Biochemical Research, Via G Colombo, 81, 20133 Milan, Italy
    J Biol Chem 280:12103-13. 2005
    ....
  55. ncbi Effect of bFGF on invasion of ovarian cancer cells through the regulation of Ets-1 and urokinase-type plasminogen activator
    Ting Li
    Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated to Tongji University, Shanghai, China
    Pharm Biol 48:161-5. 2010
    ..bFGF can enhance the invasion ability of ovarian cancer cells in vitro by inducing the expression of uPA, and this effect is also regulated by the transcription factor Ets-1...
  56. pmc ATP differentially upregulates fibroblast growth factor 2 and transforming growth factor α in neonatal and adult mice: effect on neuroproliferation
    C Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 177:335-46. 2011
    ..We tested the hypotheses that ATP induces the synthesis and secretion of two neurotrophic factors, fibroblast growth factor 2 (FGF2) and transforming growth factor alpha (TGFα), and that these neurotrophic factors have a role in ..
  57. ncbi Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo
    Sandrine Joly
    Laboratory for Retinal Cell Biology, Department of Ophthalmology, Center for Integrative Human Physiology and Neuroscience Center Zurich, University of Zurich, 8091 Zurich, Switzerland
    J Neurosci 28:13765-74. 2008
    ..Our data establish LIF as a Muller cell derived neuronal survival factor which controls an intrinsic protective mechanism that includes Edn2 signaling to support photoreceptor cell survival and to preserve vision in the injured retina...
  58. ncbi Long-term maintenance of undifferentiated human embryonic and induced pluripotent stem cells in suspension
    Mehran Rezaei Larijani
    Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, The Academic Center for Education, Culture and Research, Tehran, Iran
    Stem Cells Dev 20:1911-23. 2011
    ..Our results will pave the way for scaled up expansion and controlled differentiation of hESCs and hiPSCs needed for cell therapy, research, and industrial applications in a bioreactor culture system...
  59. ncbi A review of the current research on the role of bFGF and VEGF in angiogenesis
    M Przybylski
    Wound Healing Research Unit, Cardiff Universtity, UK
    J Wound Care 18:516-9. 2009
    ..Basic fibroblast growth factor and vascular endothelial growth factor are thought to play a synergistic role in angiogenesis. They are released into the wound bed during haemostasis and promote the formation of new blood vessels...
  60. ncbi Epidermal growth factor, basic fibroblast growth factor and platelet-derived growth factor-bb can substitute for fetal bovine serum and compete with human platelet-rich plasma in the ex vivo expansion of mesenchymal stromal cells derived from adipose tiss
    Katia Chieregato
    Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy
    Cytotherapy 13:933-43. 2011
    ..We analyzed the effect of four different medium supplements on the expansion and differentiation of adipose tissue-derived MSC (ADSC) in order to avoid the use of xenogeneic serum...
  61. ncbi Fibroblast growth factor-2 increases the expression of neurogenic genes and promotes the migration and differentiation of neurons derived from transplanted neural stem/progenitor cells
    E Vergaño-Vera
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avda Dr Arce 37, E 28002 Madrid, Spain
    Neuroscience 162:39-54. 2009
    ..Hence, the migration and maturation of neurons derived from transplanted NSC can be promoted by upregulating neurogenic gene expression with FGF-2...
  62. ncbi Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer
    Jinping Lai
    Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 278:23107-17. 2003
    ..Collectively, these observations provide evidence that HSulf-1 modulates signaling by heparin-binding growth factors, and HSulf-1 down-regulation represents a novel mechanism by which cancer cells can enhance growth factor signaling...
  63. ncbi Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    Guozhi Xiao
    Department of Periodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 277:36181-7. 2002
    b>Fibroblast growth factor 2 (FGF-2) is an important regulator of bone formation and osteoblast activity. However, its mechanism of action on bone cells is largely unknown...
  64. ncbi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    b>Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis...
  65. pmc Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 113:1701-10. 2004
    ..This study shows that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach...
  66. ncbi Fgf-2 regulates enamel and dentine formation in mouse tooth germ
    T Tsuboi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Japan
    Calcif Tissue Int 73:496-501. 2003
    ..This histological change was recovered by adding exogeneous FGF-2. These findings suggest that FGF-2 at the bell stage regulates cell differentiation and matrix secretion...
  67. ncbi Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential
    Ali Fakhry
    Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, 4010 Locust Street, Philadelphia, PA 19104, USA
    Bone 36:254-66. 2005
    ....
  68. ncbi Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 102:2108-14. 2003
    ..In addition, blockage of either JAM-1 or alphavbeta3 inhibits bFGF-induced MAP kinase activation. Thus, our results suggest that signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis...
  69. ncbi Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms
    Kirsten Haastert
    Department of Neuroanatomy, Hannover Medical School, OE 4140, Carl Neuberg Str 1, 30625 Hannover, Germany
    Neurobiol Dis 21:138-53. 2006
    ..The results contribute to the development of new therapeutic strategies in peripheral nerve repair...
  70. ncbi Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell
    M Mochii
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Japan
    Dev Biol 193:47-62. 1998
    ..The expression patterns of pax6 and Mitf are complementary both in vivo in vitro. Overexpression of Mitf inhibited expression of pax6 in cultured rPECs. These observations suggest that Mitf regulates pax6 expression negatively...
  71. ncbi Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA
    Sophie Bonnal
    INSERM U589, Institut Louis Bugnard, Hopital Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France
    J Biol Chem 280:4144-53. 2005
    Alternative initiation of translation of the human fibroblast growth factor 2 (FGF-2) mRNA at five in-frame CUG or AUG translation initiation codons requires various RNA cis-acting elements, including an internal ribosome entry site (IRES)..
  72. pmc Fibroblast growth factor 2 promotes endothelial differentiation of adipose tissue-derived stem cells
    Hongxiu Ning
    University of California, School of Medicine, Knuppe Molecular Urology Laboratory Department of Urology, San Francisco, California 94143, USA
    J Sex Med 6:967-79. 2009
    ..Adipose tissue-derived stem cells (ADSC) could potentially restore endothelial function in vasculogenic erectile dysfunction (ED). The mechanism for ADSC endothelial differentiation remained unidentified...
  73. ncbi Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription
    Chu Huang Chen
    MS A 601, Department of Medicine, Baylor College of Medicine, 6565 Fannin St, Houston, Texas 77030, USA
    Circulation 107:2102-8. 2003
    ..Apoptosis of vascular endothelial cells (ECs) can be induced in vitro by experimentally modified LDL. Description of proapoptotic circulating lipoproteins may significantly enhance understanding of atherothrombosis pathophysiology...
  74. ncbi Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability
    Zhinong Huang
    Orthopaedic Research Laboratory, Edwards Building R116, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, United States
    Cytokine 51:305-10. 2010
    ..Selective, temporally specific addition of growth factors, such as BMP-2 and VEGF appears to be an important strategy to enhance osteogenesis...
  75. ncbi The role of exogenous fibroblast growth factor-2 on the reprogramming of primordial germ cells into pluripotent stem cells
    Gabriela Durcova-Hills
    The Wellcome Trust Cancer United Kingdom Gurdon Institute of Cancer and Developmental Biology, Cambridge
    Stem Cells 24:1441-9. 2006
    ..We propose that it is from this reprogrammed component of the now heterogeneous PGC population that pluripotent stem cells arise...
  76. pmc A novel serum-free medium for the expansion of human mesenchymal stem cells
    Lucas G Chase
    Primary and Stem Cell Systems, Life Technologies, 501 Charmany Drive, Madison, WI 53719, USA
    Stem Cell Res Ther 1:8. 2010
    ..The ill-defined and highly variable nature of traditional culture media remains a challenge, hampering both the basic and clinical human MSC research fields. To date, no reliable serum-free medium for human MSCs has been available...
  77. ncbi FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells
    C Martin
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
    Dev Biol 297:402-16. 2006
    ..b>Fibroblast growth factor 2 (FGF2) has been involved in the regulation of these processes, and although it has been suggested that ..
  78. pmc Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2
    Cristina de Alvaro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    Mol Biol Cell 16:4454-61. 2005
    ..This work is the first evidence of the contribution of sprouty genes to myogenic differentiation in the presence of FGF2...
  79. ncbi Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2
    Y Arsenijevic
    Division of Surgical Research and Gene Therapy Center, Pavillon 4 Centre Hospitalier Universitaire Vaudois, 1004 Lausanne, Switzerland
    J Neurosci 21:7194-202. 2001
    ..These findings suggest that IGF-I is a key factor in the regulation of NSC activation and that EGF and FGF-2 control striatal NSC proliferation, in part, through distinct intracellular mechanisms...
  80. pmc Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway
    S Kamura
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Br J Cancer 103:370-81. 2010
    ..However, the role of bFGF in the invasive and metastatic phenotype of ESFT has not been investigated...
  81. ncbi Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis
    Huajun Zhao
    Division of Anti tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P R China
    Cancer Res 66:8779-87. 2006
    ..These findings suggest that JG3 should be considered as a promising candidate agent for cancer therapy...
  82. ncbi HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma
    Jin Ping Lai
    Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Oncogene 23:1439-47. 2004
    ....
  83. ncbi Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions
    Heesang Song
    Cardiovascular Research Institute, Brain Korea 21 Project for Medical Science, Cardiology Division, Yonsei University College of Medicine, Seoul 120 752, Korea
    Mol Cells 19:402-7. 2005
    ..1) increased, and new blood vessels formed. These data suggest that genetic modification of MSCs before transplantation could be useful for treating myocardial infarction and end-stage cardiac failure...
  84. ncbi Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Urol 183:1744-50. 2010
    ....
  85. pmc Dose-dependent response of FGF-2 for lymphangiogenesis
    Lynn K Chang
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:11658-63. 2004
    ..We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse cornea...
  86. pmc Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats
    Taiga Shibata
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes 57:3099-107. 2008
    ..This study was conducted to investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats...
  87. pmc Tripotential differentiation of adherently expandable neural stem (NS) cells
    Tamara Glaser
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany
    PLoS ONE 2:e298. 2007
    ..In the presence of fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF), this population can be continuously expanded in adherent ..
  88. ncbi Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis
    Marco Rusnati
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Blood 104:92-9. 2004
    ..PTX3/FGF2 interaction may modulate angiogenesis in various physiopathologic conditions driven by inflammation, innate immunity, and/or neoplastic transformation...
  89. ncbi Retardation of retinal vascular development in apelin-deficient mice
    Atsushi Kasai
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, OsakaUniversity, Japan
    Arterioscler Thromb Vasc Biol 28:1717-22. 2008
    ..Apelin is an endogenous ligand for the G protein-coupled receptor, APJ, and participates in multiple physiological processes. To identify the roles of endogenous apelin, we investigated the phenotype of apelin-deficient (apelin-KO) mice...
  90. ncbi Structural basis for FGF receptor dimerization and activation
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 98:641-50. 1999
    ..A general model for FGF- and heparin-induced FGFR dimerization is inferred from the crystal structure, unifying a wealth of biochemical data...
  91. ncbi A direct role for phosphatidylinositol-4,5-bisphosphate in unconventional secretion of fibroblast growth factor 2
    Koen Temmerman
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Traffic 9:1204-17. 2008
    b>Fibroblast growth factor 2 (FGF-2) is a mitogen that is exported from cells by an endoplasmic reticulum/Golgi-independent secretory pathway...
  92. ncbi In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    S C Zhang
    Department of Anatomy, University of Wisconsin 1500 Highland Avenue, Madison, WI 53705, USA
    Nat Biotechnol 19:1129-33. 2001
    ..bodies, differentiating ES cells formed large numbers of neural tube-like structures in the presence of fibroblast growth factor 2 (FGF-2)...
  93. ncbi Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein
    Peter Claus
    Department of Neuroanatomy, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 278:479-85. 2003
    b>Fibroblast growth factor 2 (FGF-2) is an important modulator of cell growth and differentiation and a neurotrophic factor...
  94. ncbi An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours
    Talal M Fael Al-Mayhani
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom
    J Neurosci Methods 176:192-9. 2009
    ..Improving the efficiency of derivation will facilitate the improvement of in vitro and in vivo model systems to study disease mechanisms, screen drugs and develop novel therapeutic approaches in the future...
  95. ncbi A high pretreatment serum basic fibroblast growth factor concentration is an independent predictor of poor prognosis in non-Hodgkin's lymphoma
    P Salven
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    Blood 94:3334-9. 1999
    ....
  96. ncbi Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity
    Bruno Delorme
    Institut National de la Recherche et Santé Médicale INSERM, Equipe ESPRI EA 3855, University Francois Rabelais, Faculty of Medicine, Tours, France
    Stem Cells 27:1142-51. 2009
    ..Our data highlight the use of BM MSCs for the cell therapy of skeletal or vascular disorders, but provide a word of caution about their use in other clinical indications...
  97. ncbi Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells
    M Mastrogiacomo
    Centro di Biotecnologie Avanzate/Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Osteoarthritis Cartilage 9:S36-40. 2001
    ..RESULTS: Among the factors assayed, fibroblast growth factor 2 (FGF2) was the most effective in promoting growth of BMSC 'in vitro'...
  98. ncbi Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord
    Yasuo Ohori
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 26:11948-60. 2006
    ..We found, however, that direct administration of fibroblast growth factor 2 and epidermal growth factor into lesioned tissue could induce a significant fraction of GFP-labeled ..
  99. ncbi Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2
    Jane Viti
    Department of Neurobiology and Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 23:5919-27. 2003
    ..We have shown previously that bone morphogenetic proteins (BMPs) and fibroblast growth factor 2 (FGF2) act antagonistically to regulate the development of a subset of SVZ progenitors that normally ..
  100. ncbi Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways
    Ileana Soto
    Institute of Neurobiology and Department of Anatomy, University of Puerto Rico Medical Sciences Campus, 201 Boulevard del Valle, Old San Juan, Puerto Rico 00901
    J Neurochem 96:82-96. 2006
    ..Our results suggest that FGF-2 acts on RGCs via FGFR1, activating the ERK pathway and CREB to increase BDNF synthesis, and PKA and CREB to increase TrkB synthesis...
  101. ncbi Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity
    Andrea Barbero
    Department of Surgery, University Hospital, Basel, Switzerland
    Osteoarthritis Cartilage 12:476-84. 2004
    ..We investigated how aging effects human chondrocyte yield, proliferation, post-expansion chondrogenic capacity, and response to specific growth factors supplemented during expansion...

Research Grants76

  1. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ....
  2. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..transcription is rapidly induced in endothelial cells in response to angiogenic signals, mediated by fibroblast growth factor 2 and epidermal growth factor...
  3. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..Knowledge thus gained will help us to advance towards our long-term objective to develop RNA interference based therapies to treat HIV infection and counteract the deleterious effects of opioid-abuse. ..
  4. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..We will test this hypothesis in vitro using iPSCs derived from the umbilical cords of babies born to mothers with severe preeclampsia and gestational age-matched control iPSCs. ..
  5. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ....
  6. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
    ..In our earlier study, we showed that fibroblast growth factor 2 (FGF-2) is the direct mediator of EMT...
  7. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Therefore, the goal of these studies is to identify novel targets for the treatment of myeloid malignancy. ..
  8. Induced Pluripotent Stem Cells from Swine: application to genetic modification
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..As the pig is an important reservoir for Salmonella, the LDLR-/- model will have a dual purpose for both agricultural and biomedical applications. ..
  9. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..this line, we have designed and synthesized several bioactive peptides, such as FGF-P (binding domain of fibroblast growth factor 2), TPO-P (binding domain shared by thrombopoietin and erythropoietin) and NPY (Neuropeptide Y) and ..
  10. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
    ..The results of the proposed studies will therefore be highly relevant for improving public health, and improving the length and quality of life of millions of patients with ischemic heart disease and heart failure. ..
  11. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..These biosensors will be designed to measure oxidized nucleosides, 8-oxodeoxyadenosine and 8-oxodeoxyguanosine, in the DNA of sperm from infertile men. ..
  12. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..The data will provide a foundation for clarifying the underlying potential pathological mechanisms of MDD in HIV-infected individuals. ..
  13. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ....
  14. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..Both aspects may offer promising leads to correct or reverse the excitatory and inhibitory neuron imbalances that are present in the cerebral cortex of neuropsychiatric and impulse control disorders. ..
  15. PROTEOLYSIS OF HMW FGF-2 BY THROMBIN AND ITS CARDIOVASCULAR IMPLICATIONS
    Giuseppe Pintucci; Fiscal Year: 2010
    ..The elucidation of these mechanisms will foster the development of new pharmacological tools for the treatment of the cardiovascular disorders associated with these diseases. ..
  16. Injury and Recovery in Developing Brain
    Flora M Vaccarino; Fiscal Year: 2013
    ..The factors under investigation include Fibroblast growth factor 2 (FGF2), the Epidermal growth factor receptor (EGFR), TrkB and its ligand Brain derived neurotropic ..
  17. BMP2 Gene Regulation in Calcific Aortic Valve Disease
    Melissa B Rogers; Fiscal Year: 2013
    ..End of Abstract) ..
  18. Role of heparin binding growth factors in vascular leakage and fatal bleeding
    Patricio E Ray; Fiscal Year: 2012
    ....
  19. Mandibular Cartilage Regeneration In Situ by Endogenous Stem Cell Recruitment
    Wendy S Vanden Berg-Foels; Fiscal Year: 2013
    ..This therapy will be easily translated to the clinic to treat patients with TMJ cartilage injuries. ..
  20. Selection of Therapeutic Agents for Articular Cartilage Repair
    Stephen B Trippel; Fiscal Year: 2013
    ..This research project is designed to determine which potential therapeutic agents are good candidates for articular cartilage gene therapy. ..
  21. Mechanisms of retinal angiogenesis
    Gadiparthi N Rao; Fiscal Year: 2013
    ....
  22. The Role of Leptin in the Vascularization of the Developing Corpus Luteum
    MICHELLE R GARCIA; Fiscal Year: 2013
    ..factors known to regulate luteal angiogenesis including vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2)...
  23. Role of FGF-Signaling in Myelinogenesis
    Rashmi Bansal; Fiscal Year: 2013
    ....
  24. Retinal Pigmented Epithelium Reprogramming and Retina Regeneration
    Katia Del Rio-Tsonis; Fiscal Year: 2013
    ..their retina, following retinectomy, via the process of trans-differentiation if exposed to ectopic fibroblast growth factor 2 (FGF2)...
  25. Regional differences in neural crest and mesodermal derived calvarial bone healin
    Michael T Longaker; Fiscal Year: 2013
    ..Identification of skull bones with superior healing potential provides insight into novel strategies that can be employed to regenerate, rather than reconstruct, skull bones. ..
  26. A Novel Mitigation Agent for Gastrointestinal Syndrome of Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2009
    ..The results of these pre-clinical studies will provide the basis for eventual approval through the animal rule. A preliminary drug development plan has already been discussed with the FDA. ..
  27. Pathogenesis of HIV-HUS in children
    Patricio E Ray; Fiscal Year: 2012
    ....
  28. Biomaterials for local regulation of growth factor signaling
    William L Murphy; Fiscal Year: 2013
    ..This proposed research program will develop a new class of materials that can be used to control the effects of growth factors during engineered tissue development, particularly vascular tissue development. ..
  29. FGF2 Isoforms in Bone and Phosphate Homeostasis
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..Our studies support an important role for the nuclear isoforms of Fibroblast Growth Factor 2 (FGF2) in FGF23 production and biologic function...
  30. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2012
    ..is to thoroughly characterize a humanized monoclonal antibody (mAb) that binds and inhibits human Fibroblast Growth Factor 2 (FGF2;basic FGF) for potential use in cancer therapy...
  31. Transcriptional control of the mouse aA-crystallin locus
    Ales Cvekl; Fiscal Year: 2013
    ....
  32. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
    ..Understanding the role of multipotent lung mesenchymal cells in the pathogenesis of BPD will lead to improvements in the treatment of this disease. ..
  33. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2013
    ..abstract_text> ..
  34. PULMONARY EFFECTS OF ENVIRONMENTAL OXIDANT POLLUTANTS
    DALLAS MELVIN HYDE; Fiscal Year: 2010
    ....
  35. Analysis of GFP Transgenes in Odontoblast in Differentiation
    Mina Mina; Fiscal Year: 2013
    ..These findings will be critical for the development of improved treatments for vital pulp therapy and improved dentin regeneration. ..
  36. Syndecan-1 and the Arterial Response to Injury
    Alexander W Clowes; Fiscal Year: 2013
    ....
  37. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ....
  38. FGF-P to treat post-irradiation GI syndrome
    Aiguo Zhang; Fiscal Year: 2013
    ..1) Gross toxicity studies;(3.2) Preparation for good manufacturing practice agent production;(3.3) Preliminary guidance meetings with the FDA. In these meetings, we will clarify best pivotal endpoints and choice of animal species. ..
  39. A Cellular and Molecular Analysis of the Intravasation Step in Tumor Metastasis
    James P Quigley; Fiscal Year: 2012
    ..The goal of the proposed research is to identify the relevant molecules and cellular processes that contribute to tumor cell spread so that clinical intervention can target those critical molecules and processes. ..
  40. Monoclonal Antibody to FGF2 for Treatment of Hepatocellular Carcinoma and Other C
    K Jin Kim; Fiscal Year: 2010
    ..objective of the proposed research is to characterize a monoclonal antibody (mAb) that binds and blocks Fibroblast Growth Factor 2 (FGF2) for potential use in cancer therapy...
  41. Autologous Lung Multipotent Stromal Cell Therapy for Emphysema
    Edward P Ingenito; Fiscal Year: 2013
    ..This trial design will allow us to recover the LMSC-treated organ for histological analysis to characterize responses to LMSC treatment at the cellular level. ..
  42. Regulation and Function of FGF23
    L Darryl Quarles; Fiscal Year: 2013
    ..Such knowledge will help us understand and better manage patients with hyperphosphatemic and hypophosphatemic disorders. ..
  43. Identification of Sulfs as therapeutic targets for the treatment of age-impaired
    Xingbin Ai; Fiscal Year: 2013
    ..Our findings may open new venues for prevention and therapy of aging-related impairment of skeletal muscle regeneration. ..
  44. Huntington's Disease and Neurogenesis
    Lisa M Ellerby; Fiscal Year: 2012
    ..We are developing a potential therapy to protect neurons or replace them in Huntington's disease. ..
  45. Signaling mechanisms of FGF2-induced cardioprotection
    Jo El Schultz; Fiscal Year: 2009
    ..Results of this proposal will provide new insights into FGF2-induced cardioprotection and may eventually lead to the pharmacologic or genetic development of FGF2 as a therapy against ischemic heart disease. ..
  46. Neurodevelopmental Basis of Anxiety and Depressive Behavior
    Sarah M Clinton; Fiscal Year: 2010
    ..Ultimately this work hopes to improve our understanding of the neurobiology of emotional disorders and help to develop improved treatments. ..
  47. Signaling mechanisms of FGF2-induced cardioprotection
    Jo El J Schultz; Fiscal Year: 2013
    ..Results of this proposal will provide new insights into FGF2-induced cardioprotection and may eventually lead to the pharmacologic or genetic development of FGF2 as a therapy against ischemic heart disease. ..
  48. Transcriptional Role of BRCA1 in Breast Cancer
    Wen Hwa Lee; Fiscal Year: 2012
    ..Especially, these natural factors that specifically suppress proliferation and induce breast cancer cell death will potentially provide a novel tumor dormancy therapy for treating breast cancer. ..
  49. Modulated release of growth factors for stimulating progenitors in aging bone
    LIISA TIINA KUHN; Fiscal Year: 2013
    ....
  50. Contribution of the vascular niche to the hematopoietic reconstitution.
    Shahin Rafii; Fiscal Year: 2012
    ....
  51. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    ..This leads us to the hypothesis that FGF receptors act cell autonomously in the absence of injury to suppress astrogliosis. ..
  52. FIBROBLAST GROWTH FACTOR SIGNALING IN HEART INJURY AND REPAIR
    David M Ornitz; Fiscal Year: 2013
    ..This knowledge will be essential to effectively design and implement FGF-based therapies for the treatment of human CVD. ..
  53. Renal Medullary Stem Cell Niche in Salt Sensitive Hypertension
    Ningjun Li; Fiscal Year: 2013
    ..abstract_text> ..
  54. Dvelopment of multi-component peptide vehicles for in vivo neuronal gene therapy
    Ester J Kwon; Fiscal Year: 2010
    ..and differentiation of NPCs through the delivery of therapeutic genes encoding mitogenic factors such as fibroblast growth factor 2 (FGF2) can cause increased recruitment to damaged areas in the brain...
  55. Investigation of Sulf regulation on the noncanonical Wnt signaling pathway
    Thanh Huu Tran; Fiscal Year: 2013
    ..We will also utilize lentivirus expressing the dominant negative Sulf2 to acutely inactivate Sulfs. ..
  56. A Novel Multilayered Membrane for Periodontal Regeneration
    Marco C Bottino; Fiscal Year: 2013
    ....
  57. Gene Transfer Treatment of Articular Cartilage Damage
    Stephen B Trippel; Fiscal Year: 2013
    ..This is a translational research project that will combine gene therapy and tissue engineering methods in a pre-clinical model to test a potential new treatment approach to articular cartilage repair. ..
  58. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..data showing that in addition to its role in promoting osteoblast (OB) function and bone formation, fibroblast growth factor 2 (FGF2) is a negative regulator of mesenchymal stem cell differentiation into mature adipocytes (AD)...
  59. Defining a sensitive period for socialization in rodents
    Arie Kaffman; Fiscal Year: 2013
    ....
  60. DIFFUSION OF SUBSTANCES THROUGH THE BRAIN
    Charles Nicholson; Fiscal Year: 2013
    ..Development of an imaging technique for fluorescent molecules will provide a relatively inexpensive method for measuring diffusion of drugs in brain tissue. ..
  61. The Biology of Perlecan in Cancer and Angiogenesis
    Renato V Iozzo; Fiscal Year: 2013
    ....
  62. METALLOPROTEINASE EXPRESSION IN CORNEAL WOUNDS
    Dimitri T Azar; Fiscal Year: 2013
    ..Transcriptional up regulation of VEGF and pericellular/transcellular ECM degradation may be two distinct mechanisms by which enzymatically active MT1-MMP promotes angiogenesis. ..
  63. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ....
  64. Defective nuclear FGFR1 signaling - a new model for PD
    MICHAL STACHOWIAK; Fiscal Year: 2003
    ..abstract_text> ..
  65. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  66. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..We hope that the results of these studies will bring important insights about the mechanisms inhibiting chronic ischemia induced endogenous angiogenesis and the response to exogenous factors in more relevant animal models of diabetes. ..
  67. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..Morphometric and immunocytochemical analyses will include areas where FGF1 and FGF2 are jointly expressed during development. ..
  68. BASIC FIBROBLAST GROWTH FACTOR EXPRESSION IN BONE CELLS
    Marja Hurley; Fiscal Year: 2003
    ..abstract_text> ..
  69. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  70. BASIC AND CLINICAL STUDIES OF COAGULATION PROTEINS
    Charles Francis; Fiscal Year: 2003
    ..The Program features a focused approach to important problems in hemostasis and vascular biology with a balance between the expertise of fundamental and clinical scientists working collaboratively. ..
  71. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..If the perichondrial cells in MCC share regulatory features with cells in SUT rather than in SOS, this assumption is not only erroneous but may lead to inappropriate treatment strategies. ..
  72. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  73. Autogeneration of an Artery: A Biomimetric Strategy
    Elliot Chaikof; Fiscal Year: 2007
    ..In addition to morphometric measurements of graft healing, the functional properties of the induced endothelial lining will be characterized using immunohistochemical and other techniques. ..
  74. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
    ..Data from this proposal may help elucidate the therapeutic efficacy of antidepressants in affective disorders. [unreadable] [unreadable]..
  75. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
    ..10 transgenic mice after administration of OVA peptide. ..
  76. ROLE OF FIBROBLAST GROWTH FACTORS IN PROSTATE GROWTH
    Michael Ittmann; Fiscal Year: 2003
    ..Their final goal is to define the role of FGF 17 as an epithelial derived paracrine inducer of stromal cell proliferation. ..