fibroblast growth factors

Summary

Summary: A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.

Top Publications

  1. pmc FGF23 induces left ventricular hypertrophy
    Christian Faul
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Clin Invest 121:4393-408. 2011
  2. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
  3. pmc FGF-21 as a novel metabolic regulator
    Alexei Kharitonenkov
    Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Invest 115:1627-35. 2005
  4. doi Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    Kenneth Lim
    Brigham and Women s Hospital, Harvard Medical School, Room 120, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    Circulation 125:2243-55. 2012
  5. pmc FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    Ffolliott M Fisher
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 26:271-81. 2012
  6. ncbi Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    Michael K Badman
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:426-37. 2007
  7. ncbi Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
  8. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
  9. doi The role of FGF/Erk signaling in pluripotent cells
    Fredrik Lanner
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Development 137:3351-60. 2010
  10. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009

Research Grants

  1. VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2014
  2. John Y L Chiang; Fiscal Year: 2016
  3. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
  4. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
  5. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
  6. Moosa Mohammadi; Fiscal Year: 2016
  7. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
  8. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
  9. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
  10. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012

Detail Information

Publications341 found, 100 shown here

  1. pmc FGF23 induces left ventricular hypertrophy
    Christian Faul
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Clin Invest 121:4393-408. 2011
    ..These results unveil a klotho-independent, causal role for FGF23 in the pathogenesis of LVH and suggest that chronically elevated FGF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD...
  2. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  3. pmc FGF-21 as a novel metabolic regulator
    Alexei Kharitonenkov
    Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Invest 115:1627-35. 2005
    ..Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes...
  4. doi Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    Kenneth Lim
    Brigham and Women s Hospital, Harvard Medical School, Room 120, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    Circulation 125:2243-55. 2012
    ..FGF-23 levels rise in chronic kidney disease (CKD) despite progression of accelerated vascular calcification. There are currently conflicting data on whether FGF-23 may exhibit direct vasculoprotective effects in CKD...
  5. pmc FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
    Ffolliott M Fisher
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 26:271-81. 2012
    ..We conclude that FGF21 acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia...
  6. ncbi Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    Michael K Badman
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:426-37. 2007
    ..These findings identify hepatic FGF21 as a critical regulator of lipid homeostasis and identify a physiological role for this hepatic hormone...
  7. ncbi Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
    ..These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation...
  8. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
    ....
  9. doi The role of FGF/Erk signaling in pluripotent cells
    Fredrik Lanner
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Development 137:3351-60. 2010
    ..Understanding how extrinsic signals such as FGF regulate different stem cell states will be crucial to harvest the clinical promise of induced pluripotent and embryo-derived stem cells...
  10. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  11. ncbi FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
    Tilo Kunath
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Development 134:2895-902. 2007
    ....
  12. doi Fibroblast growth factor 21 corrects obesity in mice
    Tamer Coskun
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Endocrinology 149:6018-27. 2008
    ..Overall, these data suggest that FGF21 exhibits the therapeutic characteristics necessary for an effective treatment of obesity and fatty liver disease and provides novel insights into the metabolic determinants of these activities...
  13. ncbi Klotho converts canonical FGF receptor into a specific receptor for FGF23
    Itaru Urakawa
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Nature 444:770-4. 2006
    ..Thus, the concerted action of Klotho and FGFR1(IIIc) reconstitutes the FGF23 receptor. These findings provide insights into the diversity and specificity of interactions between FGF and FGF receptors...
  14. pmc The FGF family: biology, pathophysiology and therapy
    Andrew Beenken
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Drug Discov 8:235-53. 2009
    The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development...
  15. doi Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    Xinmei Zhang
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 57:1246-53. 2008
    ..This study aimed to investigate the relationship between its serum levels and various cardiometabolic parameters in humans...
  16. pmc Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    Jing Xu
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California, USA
    Diabetes 58:250-9. 2009
    ..The aims of the current study are to evaluate the role of FGF21 in energy metabolism and to provide mechanistic insights into its glucose and lipid-lowering effects in a high-fat diet-induced obesity (DIO) model...
  17. pmc Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    Paul A Dutchak
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Cell 148:556-67. 2012
    ..Adding back FGF21 prevents sumoylation and restores PPARγ activity. Collectively, these results reveal FGF21 as a key mediator of the physiologic and pharmacologic actions of PPARγ...
  18. pmc Fibroblast growth factors
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genome Biol 2:REVIEWS3005. 2001
    b>Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans...
  19. ncbi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
    J Bone Miner Res 19:429-35. 2004
    ..This study indicates that FGF-23 is a potent regulator of the vitamin D and phosphate metabolism...
  20. doi Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 207:546-51. 2009
    ..Additional longitudinal studies that evaluate the predictive power of FGF23 and whether FGF23 has additional clinical applications are needed...
  21. doi Mitochondrial myopathy induces a starvation-like response
    Henna Tyynismaa
    Research Program of Molecular Neurology, Biomedicum Helsinki, 00290 Helsinki, Finland
    Hum Mol Genet 19:3948-58. 2010
    ..These results may have important implications for understanding the metabolic consequences of mitochondrial myopathies...
  22. pmc βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
    Xunshan Ding
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 16:387-93. 2012
    ..Taken together, these data demonstrate that βKlotho is essential for FGF21 activity and that βKlotho in adipose tissue contributes to the beneficial metabolic actions of FGF21...
  23. ncbi Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
    Ludovic Vallier
    Department of Surgery and Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    J Cell Sci 118:4495-509. 2005
    ....
  24. pmc FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis
    Jessica Kendrick
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:1913-22. 2011
    ..In conclusion, in advanced CKD, FGF-23 strongly and independently associates with all-cause mortality, cardiovascular events, and initiation of chronic dialysis...
  25. ncbi Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension
    Ruth Diez del Corral
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    Neuron 40:65-79. 2003
    ..Our data demonstrate that FGF and RA pathways are mutually inhibitory and suggest that their opposing actions provide a global mechanism that controls differentiation during axis extension...
  26. pmc Regulation of fibroblast growth factor-23 signaling by klotho
    Hiroshi Kurosu
    Department of Pathology, Pediatrics, and Internal Medicine and Applied Genomics, Genzyme Corporation, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:6120-3. 2006
    ..Thus, Klotho functions as a cofactor essential for activation of FGF signaling by FGF23...
  27. pmc Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    Klementina Fon Tacer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Endocrinol 24:2050-64. 2010
    ..This FGF atlas provides an important resource for guiding future studies to elucidate the physiological functions of FGFs in adult animals...
  28. pmc Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
    Ffolliott M Fisher
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2781-9. 2010
    ..However, the expected beneficial effects of endogenous FGF21 to increase glucose tolerance and reduce circulating triglycerides are absent in obesity...
  29. doi FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease
    Mahmut I Yilmaz
    Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
    Kidney Int 78:679-85. 2010
    ..There was no independent association between FGF-23 and nitroglycerin. Thus, attenuation of FMD by ADMA suggests that this endogenous inhibitor of NO synthase may, in part, mediate the vascular effects of FGF-23 in patients with CKD...
  30. pmc Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
    Aline Martin
    University of Tennessee Health Science Center, 956 Court Ave, Memphis TN 38163, USA
    FASEB J 25:2551-62. 2011
    ..These findings indicate that PHEX and DMP1 control a common pathway regulating bone mineralization and FGF23 production, the latter involving activation of the FGFR signaling in osteocytes...
  31. ncbi Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
    F Reifers
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:2381-95. 1998
    ..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others...
  32. pmc Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:15694-700. 2006
    In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1-4)...
  33. doi FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst
    Yojiro Yamanaka
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada
    Development 137:715-24. 2010
    ..In conclusion, we propose a model in which stochastic and progressive specification of EPI and PE lineages occurs during maturation of the blastocyst in an FGF/MAP kinase signal-dependent manner...
  34. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
    ..We conclude that, during early lung development, localized sources of FGF10 in the mesoderm regulate endoderm proliferation and bud outgrowth...
  35. ncbi A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
    Marios P Stavridis
    Division of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 134:2889-94. 2007
    ....
  36. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    b>Fibroblast growth factors (FGFs) are essential molecules for mammalian development...
  37. ncbi Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 2:217-25. 2005
    ..These studies define FGF15 and FGFR4 as components of a gut-liver signaling pathway that synergizes with SHP to regulate bile acid synthesis...
  38. ncbi Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study
    Danilo Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Am Soc Nephrol 18:2600-8. 2007
    ..In conclusion, FGF23 is a novel independent predictor of progression of renal disease in patients with nondiabetic CKD. Its pathophysiological significance remains to be elucidated...
  39. doi Relationship between circulating FGF23 and total body atherosclerosis in the community
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Nephrol Dial Transplant 24:3125-31. 2009
    ..Data on the association between FGF23 and atherosclerosis, both in CKD and in the community, is limited...
  40. doi Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells
    Boris Greber
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D 48149 Munster, Germany
    Cell Stem Cell 6:215-26. 2010
    ..Our data extend the current model of cell fate decisions concerning EpiSCs by clarifying the distinct roles played by FGF signaling...
  41. pmc Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
    Matthew J Potthoff
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Genes Dev 26:312-24. 2012
    We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones...
  42. pmc Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
    T Shimada
    Pharmaceutical Research Laboratory, Nephrology, Kirin Brewery Co Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Proc Natl Acad Sci U S A 98:6500-5. 2001
    ..We conclude that overproduction of FGF23 causes TIO, whereas mutations in the FGF23 gene result in autosomal dominant hypophosphatemic rickets possibly by preventing proteolytic cleavage and enhancing biological activity of FGF23...
  43. ncbi Fibroblast growth factor signaling during early vertebrate development
    Ralph T Böttcher
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Endocr Rev 26:63-77. 2005
    b>Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation...
  44. ncbi Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    Orlando Gutierrez
    Department of Medicine Internal Medicine Residency Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Am Soc Nephrol 16:2205-15. 2005
    ..Increased FGF-23 may contribute to maintaining normal serum phosphate levels in the face of advancing CKD but may worsen calcitriol deficiency and thus may be a central factor in the early pathogenesis of SHPT...
  45. ncbi The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    Alexei Kharitonenkov
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocrinology 148:774-81. 2007
    ..These data support the development of FGF-21 for the treatment of diabetes and other metabolic diseases...
  46. doi PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and o
    Felicia Ng
    Genome and Gene Expression Analysis Group, Bioinformatics Institute, Agency for Science Technology and Research A STAR, Singapore
    Blood 112:295-307. 2008
    ..Thus, this study illustrates it is possible to predict signaling pathways active in cellular differentiation and growth using microarray data and experimentally verify these predictions...
  47. doi Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Atherosclerosis 205:385-90. 2009
    ..Since CV disease is a major cause of death in CKD, we investigated the association between FGF23 and vascular function...
  48. pmc Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease
    Eric N Taylor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am Heart J 161:956-62. 2011
    ..Fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and phosphorus all have been proposed as plasma biomarkers for the development of coronary heart disease (CHD) in individuals with normal renal function...
  49. pmc FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality
    Victoria Shalhoub
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA, USA
    J Clin Invest 122:2543-53. 2012
    ..Thus, mineral disturbances caused by neutralization of FGF23 limited the efficacy of FGF23-Ab and likely contributed to the increased mortality observed in this CKD-MBD rat model...
  50. pmc Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    Hiroshi Kurosu
    Departments of Pathology and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Biol Chem 282:26687-95. 2007
    ..We conclude that the expression of betaKlotho, in combination with particular FGFR isoforms, determines the tissue-specific metabolic activities of FGF19 and FGF21...
  51. pmc Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:407-12. 2010
    ..We propose that peptides derived from the C-terminal tail of FGF23 or peptidomimetics and small-molecule organomimetics of the C-terminal tail can be used as therapeutics to treat renal phosphate wasting...
  52. pmc Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
    Martin H de Borst
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 22:1603-9. 2011
    ..Here we examine current evidence for an interaction between the RAAS and the vitamin D-FGF-23-klotho axis as well as its possible implications for progression of CKD...
  53. ncbi An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    E N Meyers
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Nat Genet 18:136-41. 1998
    ..Analysis of embryos carrying different combinations of these alleles revealed requirements for Fgf8 gene function during gastrulation, as well as cardiac, craniofacial, forebrain, midbrain and cerebellar development...
  54. ncbi Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
    Ling Fu
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Endocrinology 145:2594-603. 2004
    ..Thus, FGF19 is able to increase metabolic rate concurrently with an increase in fatty acid oxidation...
  55. doi Forging forward with 10 burning questions on FGF23 in kidney disease
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, CRB, C 221, Room 819, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1427-35. 2010
    ..Ten burning questions must be addressed to galvanize FGF23 research further in CKD...
  56. pmc Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 79:1370-8. 2011
    ..Hence, FGF23 measurements may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels...
  57. pmc FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis
    Serkan Kir
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA
    Science 331:1621-4. 2011
    ..FGF19 treatment restored the loss of glycogen in diabetic animals lacking insulin. Thus, FGF19 activates a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism...
  58. ncbi FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:1446-65. 2002
  59. ncbi Cellular signaling by fibroblast growth factor receptors
    V P Eswarakumar
    Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, P O Box 208066, SHM B 295, New Haven, CT 06520, USA
    Cytokine Growth Factor Rev 16:139-49. 2005
    ....
  60. doi Fibroblast growth factors and their receptors in cancer
    Jørgen Wesche
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Biochem J 437:199-213. 2011
    FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life...
  61. pmc FGF signalling: diverse roles during early vertebrate embryogenesis
    Karel Dorey
    The Healing Foundation Centre, Michael Smith Building, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Development 137:3731-42. 2010
    ..Here, we summarise our current understanding of the regulation and roles of FGF signalling during early vertebrate development...
  62. ncbi Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
    ..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage...
  63. ncbi Structural basis for fibroblast growth factor receptor activation
    Moosa Mohammadi
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, MSB 425, New York, NY 10016, USA
    Cytokine Growth Factor Rev 16:107-37. 2005
    ....
  64. ncbi Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    Tobias Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Kidney Int 64:2272-9. 2003
    ..We therefore hypothesized that FGF-23 levels may be altered in hyperphosphatemia associated with renal failure and that its concentration changes in response to different levels of phosphate intake...
  65. ncbi PPARalpha is a key regulator of hepatic FGF21
    Thomas Lundåsen
    Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 360:437-40. 2007
    ..Further studies on the mechanisms of regulation of FGF21 by PPARalpha in humans will be of great interest...
  66. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
    ..Chronic exposure to FGF21 markedly inhibits growth in mice. These data suggest a central role for FGF21 in inhibiting growth as part of its broader role in inducing the adaptive response to starvation...
  67. pmc Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin
    Mohga M El-Abbadi
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 75:1297-307. 2009
    ..These findings suggest that phosphate loading and the severity of uremia play critical roles in controlling arterial medial calcification in mice. Further, FGF-23 and osteopontin may be markers and/or inducers of this process...
  68. doi Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients
    Mohamed M Nasrallah
    Department of Nephrology, School of Medicine, Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Nephrol Dial Transplant 25:2679-85. 2010
    ..We conducted this study to investigate the relationship between FGF-23 and aortic calcification in a standard haemodialysis setting...
  69. pmc Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    J Biochem 149:121-30. 2011
    b>Fibroblast growth factors (FGFs) are a family of structurally related polypeptides that are essential for embryonic development and that function postnatally as homoeostatic factors, in the response to injury, in the regulation of ..
  70. pmc Regulation and function of the FGF23/klotho endocrine pathways
    Aline Martin
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Physiol Rev 92:131-55. 2012
    ..This review discusses the known and emerging functions of FGF23, its regulation in response to systemic and local signals, as well as the implications of FGF23 in different pathological and physiological contexts...
  71. pmc Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:3143-8. 2012
    ..Therefore, FGF21 is a critical rheostat for bone turnover and a key integrator of bone and energy metabolism. These results reveal that skeletal fragility may be an undesirable consequence of chronic FGF21 administration...
  72. pmc Fibroblast growth factor-23 and death, heart failure, and cardiovascular events in community-living individuals: CHS (Cardiovascular Health Study)
    Joachim H Ix
    Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Am Coll Cardiol 60:200-7. 2012
    ....
  73. pmc An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
    William L Holland
    Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8549, USA
    Cell Metab 17:790-7. 2013
    ..Collectively, these data suggest that FGF21 is a potent regulator of adiponectin secretion and that FGF21 critically depends on adiponectin to exert its glycemic and insulin sensitizing effects...
  74. ncbi Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals
    Michael A Fox
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 129:179-93. 2007
    ..Thus, multiple target-derived signals permit discrete control of the formation, maturation, and maintenance of presynaptic specializations...
  75. doi The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man
    Cecilia Gälman
    Department of Endocrinology, Metabolism and Diabetes, Molecular Nutrition Unit, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Cell Metab 8:169-74. 2008
    ..The wide interindividual variation and the induction of ketogenesis independent of FGF21 levels indicate that the physiological role of FGF21 in humans may differ from that in mice...
  76. pmc The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study
    Benjamin D Parker
    Division of Nephrologyand Hypertension, Department of Medicine, University of California San Diego, CA 92161, USA
    Ann Intern Med 152:640-8. 2010
    ..Whether circulating levels of each are associated with cardiovascular disease (CVD) events or mortality in populations without end-stage renal disease is unknown...
  77. pmc FGF-23: More than a regulator of renal phosphate handling?
    Harald Juppner
    Endocrine Unit and Pediatric Nephrology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Bone Miner Res 25:2091-7. 2010
    ..Nonetheless, reducing the production and/or the biologic activity of FGF-23 may be an important therapeutic goal for this patient population...
  78. doi Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
    Hisashi Hasegawa
    Innovative Drug Research Laboratories, Kyowa Hakko Kirin, Tokyo, Japan
    Kidney Int 78:975-80. 2010
    ....
  79. pmc Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:E1146-55. 2011
    ....
  80. ncbi Fibroblast growth factors, their receptors and signaling
    C J Powers
    School of Nursing, Department of Pharmacology, Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Endocr Relat Cancer 7:165-97. 2000
    b>Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly...
  81. ncbi Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection
    Melody Baddoo
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cell Biochem 89:1235-49. 2003
    ..Therefore, FGF2 appears to function as a mitogen and self-maintenance factor for murine MSCs enriched from bone marrow by negative selection...
  82. pmc Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    Jason A Holt
    Nuclear Receptor Discovery Research, High Throughput Biology, Gene Interference, Transgenics, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 17:1581-91. 2003
    ..This signaling cascade defines a novel mechanism for feedback repression of bile acid biosynthesis and underscores the vital role of FXR in the regulation of multiple pathways of cholesterol catabolism in the liver...
  83. ncbi Neocortex patterning by the secreted signaling molecule FGF8
    T Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 294:1071-4. 2001
    ..These findings support a role for FGF signaling in specifying positional identity in the neocortex...
  84. ncbi Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men
    Serge L Ferrari
    Service of Bone Diseases, Geneva University Hospital, 24 Rue Micheli du Crest, Geneva 1211, Switzerland
    J Clin Endocrinol Metab 90:1519-24. 2005
    ..These data suggest that FGF-23 may be implicated in the physiological regulation of Pi homeostasis in response to dietary phosphate changes, independent of PTH...
  85. ncbi Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling
    Katherine Shim
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, California 94143, USA
    Dev Cell 8:553-64. 2005
    ..Our results provide evidence that antagonism of FGF signaling by SPRY2 is essential for establishing the cytoarchitecture of the organ of Corti and for hearing...
  86. pmc BetaKlotho is required for metabolic activity of fibroblast growth factor 21
    Yasushi Ogawa
    Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7432-7. 2007
    ..Importantly, administration of FGF21 into mice induces MAP kinase phosphorylation in white adipose tissue and not in tissues without betaKlotho expression. Thus, betaKlotho functions as a cofactor essential for FGF21 activity...
  87. ncbi Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
    Jason R Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:2116-24. 2007
    ....
  88. ncbi Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
    b>Fibroblast Growth Factors (FGFs) are polypeptides with diverse activities in development and physiology...
  89. pmc Distinct FGFs promote differentiation of excitatory and inhibitory synapses
    Akiko Terauchi
    Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Nature 465:783-7. 2010
    ..These results demonstrate that specific FGFs act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain...
  90. pmc Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    H Min
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789 USA
    Genes Dev 12:3156-61. 1998
    ..The pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog...
  91. ncbi FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bioessays 22:108-12. 2000
    b>Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for cell surface heparan sulfate proteoglycans...
  92. doi Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients
    Heng Jung Hsu
    School of Medicine, Chang Gung University, and Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan
    Am J Med Sci 337:116-22. 2009
    ..Hyperphosphatemia is associated with LVH. Previous studies have shown that fibroblast growth factor 23 (FGF23), which has an important role in phosphate metabolism, is elevated in chronic hemodialysis patients...
  93. pmc Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation
    Yongde Luo
    IBT Proteomics and Nanotechnology Laboratory, Institute of Biosciences and Technology, Texas A and MHealth Science Center, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:30069-78. 2010
    ....
  94. pmc Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Biol 27:3417-28. 2007
    Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis...
  95. ncbi Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    T Nishimura
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Biochim Biophys Acta 1492:203-6. 2000
    ..Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19...
  96. pmc Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
    Mohammed S Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    FASEB J 20:720-2. 2006
    ..Finally, our data support a new model of interactions among Fgf-23, vitamin D, and klotho, a gene described as being associated with premature aging process...
  97. ncbi The amniote primitive streak is defined by epithelial cell intercalation before gastrulation
    Octavian Voiculescu
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 449:1049-52. 2007
    ....
  98. doi Capture of authentic embryonic stem cells from rat blastocysts
    Mia Buehr
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, Edinburgh EH93JQ, UK
    Cell 135:1287-98. 2008
    ..Rat ES cells will also provide a refined test-bed for functional evaluation of pluripotent stem cell-derived tissue repair and regeneration...
  99. pmc Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    Alberto O Chavez
    Division of Diabetes, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 32:1542-6. 2009
    ..FGF-21 may play a role in pathogenesis of hepatic and whole-body insulin resistance in type 2 diabetes...
  100. ncbi Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification
    H V Isaacs
    Department of Zoology, University of Oxford, UK
    Development 114:711-20. 1992
    ....
  101. ncbi The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
    L Glazer
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 5:697-705. 1991
    ..However, the extension of tracheal cell processes leading to the formation of the elaborate tree structure is blocked. The DFGF-R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth...

Research Grants110 found, 100 shown here

  1. VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2014
    ....
  2. John Y L Chiang; Fiscal Year: 2016
    ..The long-term objectives of this research are to elucidate the molecular mechanism of regulation of CYP7A1 and bile acid metabolism, and pathogenesis and treatment of metabolic diseases such as fatty liver disease, diabetes and obesity. ..
  3. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..We can also analyze tyrosine phosphorylation of the proteins and determine if they physically interact with each other in the embryo. ..
  4. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ....
  5. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..The ultimate goal of this research is to identify mechanisms that contribute to interneuron maturation and survival, possibly leading to novel therapies aimed at preventing or reversing interneuron disruption in psychiatric illnesses. ..
  6. Moosa Mohammadi; Fiscal Year: 2016
    ..Since substrate recruitment and phosphorylation by RTKs is a general event in RTK signaling, the mechanistic insights gained under Aim IV will also be directly applicable to the entire RTK superfamily. ..
  7. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..Knowledge thus gained will help us to advance towards our long-term objective to develop RNA interference based therapies to treat HIV infection and counteract the deleterious effects of opioid-abuse. ..
  8. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..These studies will advance our understanding of the regulation of ASBT and provide new ways to understand and treat intestinal and liver diseases. ..
  9. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..gene expression profile includes inflammatory mediators, as well as tissue remodeling cytokines, such as fibroblast growth factors (FGF), bone morphogenetic proteins (BMP), vascular endothelial growth factor (VEGF), etc...
  10. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012
    ..The research described in this proposal will help better define the function of FGF23 in healthy children to enhance our understanding of bone and mineral metabolism and bone mass accrual during childhood. ..
  11. Gadiparthi N Rao; Fiscal Year: 2015
    ....
  12. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
    ..Such detailed information is crucial for targeting the specific stage and specific pathway before inflammation causes an irreversible EMT. ..
  13. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    ..Our hypothesis is that ROS activate the angiopoietin (Ang) signaling pathway in the infarcted myocardium, thus stimulating vessel maturation and stabilization. ..
  14. Michelle Denburg; Fiscal Year: 2016
    ....
  15. Manipulation of Host Angiogenesis as a Therapeutic Strategy against Invasive Pulm
    Dimitrios P Kontoyiannis; Fiscal Year: 2010
    ....
  16. Jacob V P Eswarakumar; Fiscal Year: 2014
    ..It is anticipated that the findings will enable the design of novel pharmacological interventions for craniofacial disorders that are caused by dysfunction in FGFRs. ..
  17. Vincent Poitout; Fiscal Year: 2015
    ..We anticipate that these findings will serve as a basis to design novel therapeutic approaches to prevent the deterioration of [unreadable]-cell function in T2D. ..
  18. Chunlin Qin; Fiscal Year: 2016
    ....
  19. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2009
    ..Drugs targeting to nuclear receptor and signaling pathways, and miRNA antagomirs may be developed for treating metabolic liver diseases. ..
  20. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
    ....
  21. Regulation of Bone Mineralization in Renal Osteodystrophy
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012
    ..Current evidence indicates that severe bone disease and growth retardation are the main long-term consequences of chronic kidney disease since childhood. ..
  22. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
  23. Characterization of Diet1, a hypercholesterolemia resistance gene
    Karen Reue; Fiscal Year: 2013
    ..Results will further elucidate the mechanisms that control cholesterol homeostasis, and may suggest new strategies for protection or treatment of hypercholesterolemia and related disorders. ..
  24. John Y L Chiang; Fiscal Year: 2016
    ..Drugs targeting to nuclear receptor and signaling pathways, and miRNA antagomirs may be developed for treating metabolic liver diseases. ..
  25. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..It would also reduce the overwhelming economic burden on health care system due to use the cheap and stable bioactive peptides rather than the expensive native proteins of growth factors. ..
  26. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ....
  27. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    ..By studying this process investigators will be that much closer to achieving regenerative repair in humans. ..
  28. Conditional Isolation of Fgf23 Activity
    Kenneth E White; Fiscal Year: 2011
    ..These disorders currently have inadequate treatments. We expect that development of an Fgf23 conditional-null animal will reveal new mechanisms involved in phosphate homeostasis, and will provide novel therapeutic targets. ..
  29. ORLANDO M GUTIERREZ; Fiscal Year: 2016
    ....
  30. DEVELOPMENT OF MAMMALIAN OOCYTE-GRANULOSA CELL COMPLEX
    John J Eppig; Fiscal Year: 2012
    ..Resolution of these mechanisms of intercellular signaling will lead to novel clinical solutions to female infertility. ..
  31. Steven C Ghivizzani; Fiscal Year: 2014
    ..4) To determine the relationship between age of intervention and the magnitude of the skeletal response following treatment with soluble FGFR3. ..
  32. Steven A Kliewer; Fiscal Year: 2016
    ..Insights from these studies may provide new clinical strategies for treating obesity, diabetes, and other forms of metabolic disease. ..
  33. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..The data will provide a foundation for clarifying the underlying potential pathological mechanisms of MDD in HIV-infected individuals. ..
  34. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..These interactions are mediated by several signaling pathways, including those activated by Fibroblast Growth Factors (FGFs) via binding to FGF receptor- tyrosine kinases...
  35. Christopher S Wilcox; Fiscal Year: 2016
    ..These are supported by the Administrative, Animal and Bioanalytical Cores. ..
  36. David M Ornitz; Fiscal Year: 2016
    ..The primary objective of this proposal is to explore and elucidate the mechanisms by which Fibroblast Growth Factors (FGFs) regulate the osteoblast lineage during skeletal growth, homeostasis and aging...
  37. Harald W Jueppner; Fiscal Year: 2016
    ....
  38. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ....
  39. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..Both aspects may offer promising leads to correct or reverse the excitatory and inhibitory neuron imbalances that are present in the cerebral cortex of neuropsychiatric and impulse control disorders. ..
  40. Jason Stubbs; Fiscal Year: 2014
    ....
  41. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..This study will develop and test class I and class II antibody mediated signal transduction as reliable indicators of transplant outcome and provide insight into mechanisms underlying antibody mediated graft injury. (End of Abstract) ..
  42. Molecular regulation of renal 125(OH)2D production by Fibroblast Growth Factor23
    Farzana Perwad; Fiscal Year: 2010
    ..Understanding how various factors control vitamin D production will provide new therapeutic strategies to treat bone disease in children with rickets, and in patients suffering from kidney failure. ..
  43. Astroglial Cells in Perinatal Brain Injury
    Flora M Vaccarino; Fiscal Year: 2012
    ..Importantly, the regenerative processes investigated in this proposal could be mimicked in adult and aged individuals, in which unfortunately cortical neuron loss is not recovered. ..
  44. Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23
    Anthony A Portale; Fiscal Year: 2013
    ....
  45. The role of Sprouty genes in development of mammalian external genitalia
    Ophir D Klein; Fiscal Year: 2012
    ..Thus, knowledge about the molecular pathways controlling genital development is of major clinical importance, and the experiments in this R01 application will enhance our knowledge of these pathways. ..
  46. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..Importantly, if our hypothesis is correct, our findings should indicate whether inhibition of TWEAK-Fn4 binding is a valid new target for the treatment of patients with acute ischemic stroke. ..
  47. Srinivasan Beddhu; Fiscal Year: 2014
    ....
  48. WILLIAM ALLEN RICKE; Fiscal Year: 2014
    ..Furthermore, we have observed increased expression of fibroblast growth factors (FGFs) and activated FGF receptors in human specimens of BPH and in our animal models...
  49. Petra Rocic; Fiscal Year: 2016
    ..The final goal of this proposal is to construct specific therapies aimed at restoration of coronary collateral growth, relevant to the clinical management of metabolic syndrome patients on AT1R blockers. ..
  50. Yongbo Lu; Fiscal Year: 2016
    ....
  51. Michael L Robinson; Fiscal Year: 2016
    ..FGF signaling also plays fundamental roles in many disease processes including cancer, but the molecular details of how FGFs elicit their effects are not fully resolved. ..
  52. Racial Differences in Phosphorus Metabolism in Health and in Kidney Disease
    ORLANDO M GUTIERREZ; Fiscal Year: 2012
    ....
  53. Jyothsna Gattineni; Fiscal Year: 2014
    ..The current therapy results in kidney stones and progressive renal injury. The identification of specific receptors for FGF23 will help in designing specific receptor antagonists and thus provide curative treatment. ..
  54. PROTEOLYSIS OF HMW FGF-2 BY THROMBIN AND ITS CARDIOVASCULAR IMPLICATIONS
    Giuseppe Pintucci; Fiscal Year: 2010
    ..The elucidation of these mechanisms will foster the development of new pharmacological tools for the treatment of the cardiovascular disorders associated with these diseases. ..
  55. Grace L Guo; Fiscal Year: 2016
    ....
  56. ANGELIKE M STATHOPOULOS; Fiscal Year: 2016
    ..For all these reasons, understanding how coordinate cell migration is controlled by FGF signaling has the potential for far-reaching impact. ..
  57. Injury and Recovery in Developing Brain
    Flora M Vaccarino; Fiscal Year: 2013
    ..The long-term goal of these studies is to identify new means of therapeutic intervention to decrease the developmental disability and neurobehavioral sequelae of preterm birth. ..
  58. The Role of FGF23 in the Pathogenesis of Chronic Kidney Disease
    ANSEL PHILIP AMARAL; Fiscal Year: 2013
    ..This research endeavors to determine the direct pathological effects of FGF23 on podocytes and on the glomerular filter function of the kidney, with the eventual aim of revealing a novel therapeutic target for CKD. ..
  59. Gregorio Valdez; Fiscal Year: 2015
    ..In addition to the training opportunities, the proposed experiments could lead to new therapeutic targets and approaches for protecting the motor system. ..
  60. GENETIC ANALYSIS OF THE MECHANISMS THAT REGULATE TOOTH MORPHOGENESIS
    GAIL ROBERTA MARTIN; Fiscal Year: 2010
    ..mice carrying mutations in Sprouty (Spry) genes, which encode proteins that antagonize signaling via Fibroblast Growth Factors (FGFs)...
  61. Patricio E Ray; Fiscal Year: 2016
    ....
  62. FGF Regulation of GnRH Neurons
    PEISAN TSAI; Fiscal Year: 2012
    ..The goal of the proposed study is to understand how a group of signaling molecules, fibroblast growth factors (FGFs), and their receptors (FGFRs) regulate the developmental maturation and postnatal functionality of ..
  63. Targeting FGFR to prevent the outgrowth of metastatic breast cancer
    MICHAEL KEITH WENDT; Fiscal Year: 2013
    ..More importantly, our studies will establish a diagnostic platform and therapeutic protocol for the inhibition of FGFR as an effective treatment option for TNBC patients undergoing metastatic tumor recurrence. ..
  64. Bryan R Kestenbaum; Fiscal Year: 2014
    ....
  65. Marta Christov; Fiscal Year: 2016
    ..The work proposed in this application will be performed at the Endocrine Unit at MGH, among a group of investigators with world-renoun expertise in bone, mineral metabolism regulation, and FGF23. ..
  66. Katia Del Rio-Tsonis; Fiscal Year: 2014
    ..Also the significance of identifying key miRNA molecules that could reprogram RPE is high considering these are small molecules highly desirable for human therapeutics. ..
  67. Lionel Christiaen; Fiscal Year: 2016
    ..abstract_text> ..
  68. MYLES S WOLF; Fiscal Year: 2016
    ..By using data from 4 ongoing NIDDK- supported studies, we will efficiently characterize FGF23 in ADPKD in an effort to guide the design of novel interventions to improve outcomes in ADPKD. ..
  69. MARJA MARIE HURLEY; Fiscal Year: 2016
    ..abstract_text> ..
  70. Regenerating the Heart with Engineered Human Cardiac Tissue
    KAREEN LOUISE KREUTZIGER COULOMBE; Fiscal Year: 2013
    ....
  71. DAVID EVAN LEAF; Fiscal Year: 2014
    ..We will test the hypothesis that elevated plasma FGF23 levels are an independent predictor of the composite clinical outcome of mortality or sustained kidney injury 90 days following cardiac surgery. ..
  72. MYLES S WOLF; Fiscal Year: 2016
    ..Our long-term goal is to develop novel therapeutic and diagnostic strategies to improve the dismal clinical outcomes experienced by patients with CKD. ..
  73. Tamara Isakova; Fiscal Year: 2016
    ....
  74. Ryan M Schweller; Fiscal Year: 2015
    ....
  75. Victoria Kolupaeva; Fiscal Year: 2016
    ..regulated by a number of signaling molecules and one of the central roles in these processes belongs to Fibroblast Growth Factors (FGFs)...
  76. Sung Ho Huh; Fiscal Year: 2014
    ..of FGF signal in cochlear formation Project Summary/Abstract I am interested in the mechanisms by which Fibroblast Growth Factors (FGFs) regulate cochlear formation...
  77. Gene Networks for Prostate Cancer Progression
    Leif Peterson; Fiscal Year: 2005
    ..Gene and protein expression studies suggest that fibroblast growth factors (FGFs) and the receptors FGFR1 and FGFR2 are linked to cellular proliferation, benign prostatic ..
  78. The role of GSH in cornea and lens development
    Vasilis Vasiliou; Fiscal Year: 2013
    ..Since the aforementioned signaling pathways are not restricted to the eye, the new knowledge derived from the proposed studies may have relevance and be extended to general embryogenesis and organogenesis. ..
  79. Marco C Bottino; Fiscal Year: 2016
    ....
  80. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..We will test the hypothesis that one possible mechanism through which FGF2 and PTH crosstalk may regulate adipogenesis is through Runx2 and Lef-1/-catenin mediated control of the PPARg 2 promoter. ..
  81. David J McConkey; Fiscal Year: 2016
    ..Achievement of the aims and objectives of this proposal will result in a major decrease in the incidence, morbidity and mortality of BC. ..
  82. Ning Wang; Fiscal Year: 2015
    ..age (to postpone age- related ovarian failure and menopause) or in female cancer patients (to rescue their ovarian function and fertility after anti-cancer treatments) - all of these conditions represent increasing ..
  83. PHTHALOCYANINE PHOTODYNAMIC THERAPY OF SKIN TUMORS
    Hasan Mukhtar; Fiscal Year: 1999
    ..Agents found to be effective will then be tested for abrogation of photosensitivity by administration to mice after Pc-PDT of skin tumors, and reexposure to light radiation vs. controls. ..
  84. David M Ornitz; Fiscal Year: 2015
    ....
  85. Role of mTORC1 In The Regulation Of Prostatic Branching Morphogenesis
    Tamara L Lotan; Fiscal Year: 2013
    ..If we can understand and manipulate these same pathways, we may discover new treatment paradigms for this important problem of public health. ..
  86. Role of FGFR1 signaling in distinct cell lineages in prostate cancer progresssion
    Michael M Ittmann; Fiscal Year: 2013
    ....
  87. Fibroblast Growth Factor Signaling in Odontogenic Epithelial Stem Cells
    Fen Wang; Fiscal Year: 2013
    ..Novel genetically engineered mouse models and novel OESC culture systems will be developed, which, together with currently available ones, will also benefit the tooth research community. ..
  88. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ....
  89. Selection of Therapeutic Agents for Articular Cartilage Repair
    Stephen B Trippel; Fiscal Year: 2013
    ..This research project is designed to determine which potential therapeutic agents are good candidates for articular cartilage gene therapy. ..
  90. SANKARAN THAYUMANAVAN; Fiscal Year: 2016
    ..has been shown that heparin sulfate (a natural polysaccharide) acts as the key scaffold for assembling fibroblast growth factors and transmembrane tyrosine kinase receptors that are important in several cellular processes, including ..
  91. Defective nuclear FGFR1 signaling - a new model for PD
    MICHAL STACHOWIAK; Fiscal Year: 2003
    ..abstract_text> ..
  92. Fibroblast Growth Factor Regulation in the Pancreas
    Sam Holmstrom; Fiscal Year: 2009
    ..Therefore, understanding the hormonal regulation of exocrine pancreas function by FGF15 may yield new therapeutic avenues with high potential for pharmacological intervention by targeting membrane receptors. ..
  93. Therapeutic Angiogenesis for Erectile Dysfunction
    BRIAN ANNEX; Fiscal Year: 2009
    ..In this renewal, we propose to identify the mechanism for hypercholesterolemia induced vascular injury as well as how to employ information gained in the studies to advance potential treatments for ED...
  94. ROLE OF PHOSPHOLIPIDS IN MINERALIZATION OF OSTEOID
    David Howell; Fiscal Year: 1992
    ..of various growth factors known to induce or regulate endothelial cell chemotaxis, such as acidic fibroblast growth factors (aFGF), basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF, transforming growth ..
  95. PHOSPHOLIPIDS AND MINERALIZATION OF OSTEOID
    David Howell; Fiscal Year: 1999
    ..of various growth factors known to induce or regulate endothelial cell chemotaxis, such as acidic fibroblast growth factors (aFGF), basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF, transforming growth ..